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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for GLRX2

check button Gene summary
Gene informationGene symbol

GLRX2

Gene ID

51022

Gene nameglutaredoxin 2
SynonymsCGI-133|GRX2
Cytomap

1q31.2

Type of geneprotein-coding
Descriptionglutaredoxin 2bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2)glutaredoxin (thioltransferase) 2
Modification date20200313
UniProtAcc

Q9NS18,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
GLRX2

GO:0010033

response to organic substance

11397793

GLRX2

GO:0042542

response to hydrogen peroxide

11397793


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RNA A-to-I events for GLRX2

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_52901(193092594, -), ADediting_52902(193092614, -), ADediting_52903(193092615, -), ADediting_52904(193092638, -), ADediting_52905(193092641, -), ADediting_52906(193092642, -), ADediting_52907(193092648, -), ADediting_52908(193092676, -), ADediting_52909(193092686, -), ADediting_52910(193092687, -), ADediting_52911(193092702, -), ADediting_52912(193092717, -), ADediting_52913(193092755, -), ADediting_52914(193092763, -), ADediting_52915(193092769, -), ADediting_52916(193092773, -), ADediting_52917(193092775, -), ADediting_52918(193092776, -), ADediting_52919(193092785, -), ADediting_52920(193092790, -), ADediting_52921(193092803, -), ADediting_52922(193092815, -), ADediting_52923(193092816, -), ADediting_52924(193092817, -), ADediting_52925(193092847, -), ADediting_52926(193092849, -), ADediting_52927(193094119, -), ADediting_52928(193094125, -), ADediting_52929(193094131, -), ADediting_52930(193094137, -), ADediting_52931(193094138, -), ADediting_52932(193094139, -), ADediting_52933(193094165, -), ADediting_52934(193094178, -), ADediting_52935(193094179, -), ADediting_52936(193094190, -), ADediting_52937(193094251, -), ADediting_52938(193094254, -), ADediting_52939(193094271, -), ADediting_52940(193094285, -), ADediting_52941(193094302, -), ADediting_52942(193094322, -), ADediting_52943(193094338, -), ADediting_52944(193094346, -), ADediting_52945(193094380, -), ADediting_52946(193095196, -), ADediting_52947(193095247, -), ADediting_52948(193095265, -), ADediting_52949(193095266, -), ADediting_52950(193095267, -), ADediting_52951(193095303, -), ADediting_52952(193095304, -), ADediting_52953(193095316, -), ADediting_52954(193095325, -), ADediting_52955(193095328, -), ADediting_52956(193095397, -), ADediting_52957(193095409, -), ADediting_52958(193095422, -), ADediting_52959(193095423, -), ADediting_52960(193095426, -), ADediting_52961(193095572, -), ADediting_52962(193095749, -), ADediting_52963(193095752, -), ADediting_52964(193095756, -), ADediting_52965(193095765, -), ADediting_52966(193095769, -), ADediting_52967(193095773, -), ADediting_52968(193095779, -), ADediting_52969(193095787, -), ADediting_52970(193095789, -), ADediting_52971(193095794, -), ADediting_52972(193095805, -), ADediting_52973(193095809, -), ADediting_52974(193095811, -), ADediting_52975(193095818, -), ADediting_52976(193095819, -), ADediting_52977(193095839, -), ADediting_52978(193095840, -), ADediting_52979(193095843, -), ADediting_52980(193095847, -), ADediting_52981(193095871, -), ADediting_52982(193095876, -), ADediting_52983(193095881, -), ADediting_52984(193095887, -), ADediting_52985(193095894, -), ADediting_52986(193095895, -), ADediting_52987(193095904, -), ADediting_52988(193095908, -), ADediting_52989(193095911, -), ADediting_52990(193095925, -), ADediting_52991(193098278, -), ADediting_52992(193098323, -), ADediting_52993(193098361, -), ADediting_52994(193098428, -), ADediting_52995(193098440, -), ADediting_52996(193098457, -), ADediting_52997(193098516, -), ADediting_52998(193098518, -), ADediting_52999(193098667, -), ADediting_53000(193098680, -), ADediting_53001(193098683, -), ADediting_53002(193098692, -), ADediting_53003(193098716, -), ADediting_53004(193098719, -), ADediting_53005(193098720, -), ADediting_53006(193098830, -), ADediting_53007(193099388, -), ADediting_53008(193099424, -), ADediting_53009(193099425, -), ADediting_53010(193099433, -), ADediting_53011(193099443, -), ADediting_53012(193099596, -), ADediting_53013(193099599, -), ADediting_53014(193099605, -), ADediting_53015(193099620, -), ADediting_53016(193100249, -), ADediting_53017(193100253, -), ADediting_53018(193100254, -), ADediting_53019(193100257, -), ADediting_53020(193100295, -), ADediting_53021(193100422, -), ADediting_53022(193100443, -), ADediting_53023(193100472, -), ADediting_1516805(193092883, -), ADediting_1516806(193094333, -), ADediting_1598073(193095810, -),

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RNA editing positional annotations for GLRX2 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_52901chr1_193092594_-UTR3
ADediting_52902chr1_193092614_-UTR3
ADediting_52903chr1_193092615_-UTR3
ADediting_52904chr1_193092638_-UTR3
ADediting_52905chr1_193092641_-UTR3
ADediting_52906chr1_193092642_-UTR3
ADediting_52907chr1_193092648_-UTR3
ADediting_52908chr1_193092676_-UTR3
ADediting_52909chr1_193092686_-UTR3
ADediting_52910chr1_193092687_-UTR3
ADediting_52911chr1_193092702_-UTR3
ADediting_52912chr1_193092717_-UTR3
ADediting_52913chr1_193092755_-UTR3
ADediting_52914chr1_193092763_-UTR3
ADediting_52915chr1_193092769_-UTR3
ADediting_52916chr1_193092773_-UTR3
ADediting_52917chr1_193092775_-UTR3
ADediting_52918chr1_193092776_-UTR3
ADediting_52919chr1_193092785_-UTR3
ADediting_52920chr1_193092790_-UTR3
ADediting_52921chr1_193092803_-UTR3
ADediting_52922chr1_193092815_-UTR3
ADediting_52923chr1_193092816_-UTR3
ADediting_52924chr1_193092817_-UTR3
ADediting_52925chr1_193092847_-UTR3
ADediting_52926chr1_193092849_-UTR3
ADediting_52927chr1_193094119_-UTR3
ADediting_52928chr1_193094125_-UTR3
ADediting_52929chr1_193094131_-UTR3
ADediting_52930chr1_193094137_-UTR3
ADediting_52931chr1_193094138_-UTR3
ADediting_52932chr1_193094139_-UTR3
ADediting_52933chr1_193094165_-UTR3
ADediting_52934chr1_193094178_-UTR3
ADediting_52935chr1_193094179_-UTR3
ADediting_52936chr1_193094190_-UTR3
ADediting_52937chr1_193094251_-UTR3
ADediting_52938chr1_193094254_-UTR3
ADediting_52939chr1_193094271_-UTR3
ADediting_52940chr1_193094285_-UTR3
ADediting_52941chr1_193094302_-UTR3
ADediting_52942chr1_193094322_-UTR3
ADediting_52943chr1_193094338_-UTR3
ADediting_52944chr1_193094346_-UTR3
ADediting_52945chr1_193094380_-UTR3
ADediting_52946chr1_193095196_-UTR3
ADediting_52947chr1_193095247_-UTR3
ADediting_52948chr1_193095265_-intronic
ADediting_52949chr1_193095266_-intronic
ADediting_52950chr1_193095267_-intronic
ADediting_52951chr1_193095303_-intronic
ADediting_52952chr1_193095304_-intronic
ADediting_52953chr1_193095316_-intronic
ADediting_52954chr1_193095325_-intronic
ADediting_52955chr1_193095328_-intronic
ADediting_52956chr1_193095397_-intronic
ADediting_52957chr1_193095409_-intronic
ADediting_52958chr1_193095422_-intronic
ADediting_52959chr1_193095423_-intronic
ADediting_52960chr1_193095426_-intronic
ADediting_52961chr1_193095572_-intronic
ADediting_52962chr1_193095749_-intronic
ADediting_52963chr1_193095752_-intronic
ADediting_52964chr1_193095756_-intronic
ADediting_52965chr1_193095765_-intronic
ADediting_52966chr1_193095769_-intronic
ADediting_52967chr1_193095773_-intronic
ADediting_52968chr1_193095779_-intronic
ADediting_52969chr1_193095787_-intronic
ADediting_52970chr1_193095789_-intronic
ADediting_52971chr1_193095794_-intronic
ADediting_52972chr1_193095805_-intronic
ADediting_52973chr1_193095809_-intronic
ADediting_52974chr1_193095811_-intronic
ADediting_52975chr1_193095818_-intronic
ADediting_52976chr1_193095819_-intronic
ADediting_52977chr1_193095839_-intronic
ADediting_52978chr1_193095840_-intronic
ADediting_52979chr1_193095843_-intronic
ADediting_52980chr1_193095847_-intronic
ADediting_52981chr1_193095871_-intronic
ADediting_52982chr1_193095876_-intronic
ADediting_52983chr1_193095881_-intronic
ADediting_52984chr1_193095887_-intronic
ADediting_52985chr1_193095894_-intronic
ADediting_52986chr1_193095895_-intronic
ADediting_52987chr1_193095904_-intronic
ADediting_52988chr1_193095908_-intronic
ADediting_52989chr1_193095911_-intronic
ADediting_52990chr1_193095925_-intronic
ADediting_52991chr1_193098278_-intronic
ADediting_52992chr1_193098323_-intronic
ADediting_52993chr1_193098361_-intronic
ADediting_52994chr1_193098428_-intronic
ADediting_52995chr1_193098440_-intronic
ADediting_52996chr1_193098457_-intronic
ADediting_52997chr1_193098516_-intronic
ADediting_52998chr1_193098518_-intronic
ADediting_52999chr1_193098667_-intronic
ADediting_53000chr1_193098680_-intronic
ADediting_53001chr1_193098683_-intronic
ADediting_53002chr1_193098692_-intronic
ADediting_53003chr1_193098716_-intronic
ADediting_53004chr1_193098719_-intronic
ADediting_53005chr1_193098720_-intronic
ADediting_53006chr1_193098830_-intronic
ADediting_53007chr1_193099388_-intronic
ADediting_53008chr1_193099424_-intronic
ADediting_53009chr1_193099425_-intronic
ADediting_53010chr1_193099433_-intronic
ADediting_53011chr1_193099443_-intronic
ADediting_53012chr1_193099596_-intronic
ADediting_53013chr1_193099599_-intronic
ADediting_53014chr1_193099605_-intronic
ADediting_53015chr1_193099620_-intronic
ADediting_53016chr1_193100249_-intronic
ADediting_53017chr1_193100253_-intronic
ADediting_53018chr1_193100254_-intronic
ADediting_53019chr1_193100257_-intronic
ADediting_53020chr1_193100295_-intronic
ADediting_53021chr1_193100422_-intronic
ADediting_53022chr1_193100443_-intronic
ADediting_53023chr1_193100472_-intronic
ADediting_1516805chr1_193092883_-UTR3
ADediting_1516806chr1_193094333_-UTR3
ADediting_1598073chr1_193095810_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_52901chr1_193092594_-SINEAluName=AluJo
ADediting_52902chr1_193092614_-SINEAluName=AluJo
ADediting_52903chr1_193092615_-SINEAluName=AluJo
ADediting_52904chr1_193092638_-SINEAluName=AluJo
ADediting_52905chr1_193092641_-SINEAluName=AluJo
ADediting_52906chr1_193092642_-SINEAluName=AluJo
ADediting_52907chr1_193092648_-SINEAluName=AluJo
ADediting_52908chr1_193092676_-SINEAluName=AluJo
ADediting_52909chr1_193092686_-SINEAluName=AluJo
ADediting_52910chr1_193092687_-SINEAluName=AluJo
ADediting_52911chr1_193092702_-SINEAluName=AluJo
ADediting_52912chr1_193092717_-SINEAluName=AluJo
ADediting_52913chr1_193092755_-SINEAluName=AluJo
ADediting_52914chr1_193092763_-SINEAluName=AluJo
ADediting_52915chr1_193092769_-SINEAluName=AluJo
ADediting_52916chr1_193092773_-SINEAluName=AluJo
ADediting_52917chr1_193092775_-SINEAluName=AluJo
ADediting_52918chr1_193092776_-SINEAluName=AluJo
ADediting_52919chr1_193092785_-SINEAluName=AluJo
ADediting_52920chr1_193092790_-SINEAluName=AluJo
ADediting_52921chr1_193092803_-SINEAluName=AluJo
ADediting_52922chr1_193092815_-SINEAluName=AluJo
ADediting_52923chr1_193092816_-SINEAluName=AluJo
ADediting_52924chr1_193092817_-SINEAluName=AluJo
ADediting_52925chr1_193092847_-SINEAluName=AluJo
ADediting_52926chr1_193092849_-SINEAluName=AluJo
ADediting_52927chr1_193094119_-SINEAluName=AluSx3
ADediting_52928chr1_193094125_-SINEAluName=AluSx3
ADediting_52929chr1_193094131_-SINEAluName=AluSx3
ADediting_52930chr1_193094137_-SINEAluName=AluSx3
ADediting_52931chr1_193094138_-SINEAluName=AluSx3
ADediting_52932chr1_193094139_-SINEAluName=AluSx3
ADediting_52933chr1_193094165_-SINEAluName=AluSx3
ADediting_52934chr1_193094178_-SINEAluName=AluSx3
ADediting_52935chr1_193094179_-SINEAluName=AluSx3
ADediting_52936chr1_193094190_-SINEAluName=AluSx3
ADediting_52937chr1_193094251_-SINEAluName=AluSx3
ADediting_52938chr1_193094254_-SINEAluName=AluSx3
ADediting_52939chr1_193094271_-SINEAluName=AluSx3
ADediting_52940chr1_193094285_-SINEAluName=AluSx3
ADediting_52941chr1_193094302_-SINEAluName=AluSx3
ADediting_52942chr1_193094322_-SINEAluName=AluSx3
ADediting_52943chr1_193094338_-SINEAluName=AluSx3
ADediting_52944chr1_193094346_-SINEAluName=AluSx3
ADediting_52945chr1_193094380_-SINEAluName=AluSx3
ADediting_52947chr1_193095247_-SINEAluName=AluSg4
ADediting_52948chr1_193095265_-SINEAluName=AluSg4
ADediting_52949chr1_193095266_-SINEAluName=AluSg4
ADediting_52950chr1_193095267_-SINEAluName=AluSg4
ADediting_52951chr1_193095303_-SINEAluName=AluSg4
ADediting_52952chr1_193095304_-SINEAluName=AluSg4
ADediting_52953chr1_193095316_-SINEAluName=AluSg4
ADediting_52954chr1_193095325_-SINEAluName=AluSg4
ADediting_52955chr1_193095328_-SINEAluName=AluSg4
ADediting_52956chr1_193095397_-SINEAluName=AluSg4
ADediting_52957chr1_193095409_-SINEAluName=AluSg4
ADediting_52958chr1_193095422_-SINEAluName=AluSg4
ADediting_52959chr1_193095423_-SINEAluName=AluSg4
ADediting_52960chr1_193095426_-SINEAluName=AluSg4
ADediting_52962chr1_193095749_-SINEAluName=AluJo
ADediting_52963chr1_193095752_-SINEAluName=AluJo
ADediting_52964chr1_193095756_-SINEAluName=AluJo
ADediting_52965chr1_193095765_-SINEAluName=AluJo
ADediting_52966chr1_193095769_-SINEAluName=AluJo
ADediting_52967chr1_193095773_-SINEAluName=AluJo
ADediting_52968chr1_193095779_-SINEAluName=AluJo
ADediting_52969chr1_193095787_-SINEAluName=AluJo
ADediting_52970chr1_193095789_-SINEAluName=AluJo
ADediting_52971chr1_193095794_-SINEAluName=AluJo
ADediting_52972chr1_193095805_-SINEAluName=AluJo
ADediting_52973chr1_193095809_-SINEAluName=AluJo
ADediting_52974chr1_193095811_-SINEAluName=AluJo
ADediting_52975chr1_193095818_-SINEAluName=AluJo
ADediting_52976chr1_193095819_-SINEAluName=AluJo
ADediting_52977chr1_193095839_-SINEAluName=AluJo
ADediting_52978chr1_193095840_-SINEAluName=AluJo
ADediting_52979chr1_193095843_-SINEAluName=AluJo
ADediting_52980chr1_193095847_-SINEAluName=AluJo
ADediting_52981chr1_193095871_-SINEAluName=AluJo
ADediting_52982chr1_193095876_-SINEAluName=AluJo
ADediting_52983chr1_193095881_-SINEAluName=AluJo
ADediting_52984chr1_193095887_-SINEAluName=AluJo
ADediting_52985chr1_193095894_-SINEAluName=AluJo
ADediting_52986chr1_193095895_-SINEAluName=AluJo
ADediting_52987chr1_193095904_-SINEAluName=AluJo
ADediting_52988chr1_193095908_-SINEAluName=AluJo
ADediting_52989chr1_193095911_-SINEAluName=AluJo
ADediting_52990chr1_193095925_-SINEAluName=AluJo
ADediting_52991chr1_193098278_-SINEAluName=AluSz
ADediting_52992chr1_193098323_-SINEAluName=AluSz
ADediting_52993chr1_193098361_-SINEAluName=AluSz
ADediting_52994chr1_193098428_-SINEAluName=AluSz
ADediting_52995chr1_193098440_-SINEAluName=AluSz
ADediting_52996chr1_193098457_-SINEAluName=AluSz
ADediting_52997chr1_193098516_-SINEAluName=AluSz
ADediting_52998chr1_193098518_-SINEAluName=AluSz
ADediting_52999chr1_193098667_-SINEAluName=AluSx1
ADediting_53000chr1_193098680_-SINEAluName=AluSx1
ADediting_53001chr1_193098683_-SINEAluName=AluSx1
ADediting_53002chr1_193098692_-SINEAluName=AluSx1
ADediting_53003chr1_193098716_-SINEAluName=AluSx1
ADediting_53004chr1_193098719_-SINEAluName=AluSx1
ADediting_53005chr1_193098720_-SINEAluName=AluSx1
ADediting_53006chr1_193098830_-SINEAluName=AluSx1
ADediting_53007chr1_193099388_-SINEAluName=AluJb
ADediting_53008chr1_193099424_-SINEAluName=AluJb
ADediting_53009chr1_193099425_-SINEAluName=AluJb
ADediting_53010chr1_193099433_-SINEAluName=AluJb
ADediting_53011chr1_193099443_-SINEAluName=AluJb
ADediting_53012chr1_193099596_-SINEAluName=AluJb
ADediting_53013chr1_193099599_-SINEAluName=AluJb
ADediting_53014chr1_193099605_-SINEAluName=AluJb
ADediting_53015chr1_193099620_-SINEAluName=AluJb
ADediting_53016chr1_193100249_-SINEAluName=AluSx1
ADediting_53017chr1_193100253_-SINEAluName=AluSx1
ADediting_53018chr1_193100254_-SINEAluName=AluSx1
ADediting_53019chr1_193100257_-SINEAluName=AluSx1
ADediting_53020chr1_193100295_-SINEAluName=AluSx1
ADediting_53021chr1_193100422_-SINEAluName=AluSx1
ADediting_53022chr1_193100443_-SINEAluName=AluSx1
ADediting_53023chr1_193100472_-SINEAluName=AluSx1
ADediting_1516805chr1_193092883_-SINEAluName=AluJo
ADediting_1516806chr1_193094333_-SINEAluName=AluSx3
ADediting_1598073chr1_193095810_-SINEAluName=AluJo

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RNA A-to-I editing events in the alternative splicing sites for GLRX2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GLRX2

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for GLRX2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for GLRX2


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1556067chr19_40282625_-ENSG00000023572.9ENST00000367439.7GLRX2-201hsa-miR-641chr11930965581930965647mer-m8193096557193096583147-16.31
ADediting_1556067chr19_40282625_-ENSG00000023572.9ENST00000367440.3GLRX2-202hsa-miR-641chr11930965581930965647mer-m8193096557193096583147-16.31
ADediting_1631458chr19_40282624_-ENSG00000023572.9ENST00000367439.7GLRX2-201hsa-miR-641chr11930965581930965647mer-m8193096557193096583147-16.31
ADediting_1631458chr19_40282624_-ENSG00000023572.9ENST00000367440.3GLRX2-202hsa-miR-641chr11930965581930965647mer-m8193096557193096583147-16.31

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GLRX2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for GLRX2

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_52905chr1_193092641_-4.43186023888772e-090.3254351820510191.5378456526335e-050.2428368946711320.233720746771296-0.0678306360254282
TCXADediting_52905chr1_193092641_-7.76954643761757e-070.390563058117533.82774103745701e-060.3670795736476640.751180695975393-0.0261036672985645
STGADediting_52905chr1_193092641_-1.39683511598034e-060.4984786545789668.03802310671324e-050.4167433160038470.647752552015785-0.0505763201269429
DLPFCADediting_52907chr1_193092648_-1.94025968866032e-150.4307885678396071.18921967846391e-110.3727040977316710.155997915021053-0.0807691135369672
TCXADediting_52907chr1_193092648_-8.47992185976883e-050.3153284311241250.0001553559077077910.3040276527886530.997834697237869-0.000223450761136476
STGADediting_52907chr1_193092648_-5.0378150515915e-050.4273083898651092.26126317597784e-060.4897937287707650.056364057309755-0.209028620246855
TCXADediting_52911chr1_193092702_-6.51156904416053e-080.4238152328010593.34770065636543e-050.3318446050327760.558472777910983-0.0481492187290409
STGADediting_52911chr1_193092702_-0.004886403573181920.304319948978490.0002822489705587410.3864628148985620.0966961708008599-0.182448453370572
CERADediting_52915chr1_193092769_-6.99056325027829e-070.3920563423047273.64759531573631e-060.3678170436458070.4495622041934940.062199503907408
TCXADediting_52915chr1_193092769_-5.18879617451377e-060.3623829657340230.0001521395368898910.3044258533518880.575554558573026-0.0460759731593707
STGADediting_52915chr1_193092769_-0.07946511289198720.1924456001163560.002460701920757310.3261964893086880.828584096751073-0.0239799539140004
CERADediting_52916chr1_193092773_-1.08962373893665e-050.350607918079219.83140435142353e-050.3126098046453250.04867905477408320.161257416135997
TCXADediting_52916chr1_193092773_-5.72912328143181e-080.4254383593771953.4425088209573e-050.3313619601197810.6697876084799170.0351015479890231
TCXADediting_52917chr1_193092775_-3.47005351358777e-050.3312240788352190.0244201924608070.1837187041162330.02077801141989170.188653353279356
CERADediting_52920chr1_193092790_-4.94044067414294e-060.3631451706417748.34757683772922e-070.3895445964075670.3452214406936240.0776018822516885
TCXADediting_52920chr1_193092790_-7.34188183727552e-070.3913641986967070.004068095224324350.2332722099628640.005161284574222060.227262291458938
STGADediting_52920chr1_193092790_-0.001060550509755970.3510370184105398.89374517936301e-050.4144087031506420.0946412202407198-0.183562851556763
CERADediting_52929chr1_193094131_-0.0007177280717521470.273209169184510.0001763377393246420.3016041337699360.02667457102607460.18097288129789
CERADediting_52936chr1_193094190_-0.0001065192995310290.3111251298105190.001065138362009390.2646502947389940.904706397800324-0.00985717109895894
TCXADediting_52936chr1_193094190_-7.95321928087347e-090.4494520382750471.4492280809679e-060.3815988975078820.753261164620481-0.0258781147368942
CERADediting_52943chr1_193094338_-0.0006941240573795310.2739215878294641.27211409669934e-060.3834953286530150.7180771098297820.0297200748848166
CERADediting_52947chr1_193095247_-1.8980031740553e-050.3414816022360130.000599144974013210.2770339832254390.6813244384389-0.0338031550472937
STGADediting_52947chr1_193095247_-0.001520202225899090.3406568186137070.0009831751531213560.3531771014037150.50030397320582-0.0745553679221502
STGADediting_52953chr1_193095316_-0.008820471997111280.284092572593577.70379225230448e-050.4177183311451740.447096023971917-0.0840643671201892
CERADediting_52956chr1_193095397_-5.98066049968586e-050.3216458529339050.0001438118294544880.3054945026861440.2322397419881870.0981247129060998
TCXADediting_52957chr1_193095409_-5.66386410708585e-070.3950092798921842.40250208881489e-050.3375175014143780.484191027236459-0.0575543817870322
STGADediting_52957chr1_193095409_-0.002154921850305370.3302498869583460.02661100314686310.2419330048338480.7041073553091020.0420493226888796
TCXADediting_52960chr1_193095426_-9.79778558153784e-060.3523234538606030.0001055157942253310.3113008546458260.308488374695642-0.0837061374851866
CERADediting_52963chr1_193095752_-8.26307895537082e-050.3158019665563590.002558692183626330.2445754319298220.395521497181323-0.0698730485646727
TCXADediting_52963chr1_193095752_-3.58526862148605e-080.4313096147411491.79343261173123e-070.410659135175070.0504082521432854-0.160053724113337
CERADediting_52965chr1_193095765_-5.57056726856947e-050.3229140519793810.002413857568551040.2459603717294520.9719462019492170.00289562920268215
TCXADediting_52965chr1_193095765_-1.08431292247014e-110.5184017216925067.91072773068325e-100.475350557388360.100647461673966-0.134561413779344
STGADediting_52965chr1_193095765_-0.0002659326325503630.3879658318182285.21229605016466e-050.4265501930547240.145455367879108-0.160210444784759
CERADediting_52966chr1_193095769_-4.46712732880382e-050.3268196709407260.005577640305010140.2252707672993560.5305842701406280.0516012129764687
TCXADediting_52966chr1_193095769_-7.20792518719895e-090.4506013819150162.52884382286793e-070.4060659430405140.530541315579129-0.0516065982755025
STGADediting_52966chr1_193095769_-0.2056929422314060.1394910642912140.0007043242761547010.3624273539512720.0197610686761556-0.253938000492855
TCXADediting_52967chr1_193095773_-5.52393375888261e-070.3953583900779870.000140736381595850.3059037958931070.9143650165144960.00885404535913092
STGADediting_52967chr1_193095773_-0.003033881019759680.3196870419838450.001048924442405680.3513493343797720.216987572312497-0.136115101792208
TCXADediting_52972chr1_193095805_-5.96953994415104e-060.3601938908108028.83442656277998e-060.3539848740777160.325434038064108-0.0808351261113562
TCXADediting_52983chr1_193095881_-0.0004513476894266350.2829253988452560.0001879830304774710.3003726349849070.513989226847498-0.053698473459228
TCXADediting_52985chr1_193095894_-1.12505687619139e-050.3500893104474520.001204334022674030.2619294175834380.620807916031647-0.0407164013117864
CERADediting_52987chr1_193095904_-2.4669428782706e-110.510603800186770.0001153169848038480.3096475236821470.814686445932628-0.0192970658103385
TCXADediting_52987chr1_193095904_-3.90113730677587e-080.4302601926159421.00761637198226e-070.418214619499410.371608182840252-0.0734670562643826
STGADediting_52987chr1_193095904_-0.002208748181922080.3295003383282860.0009808036559040060.353245080451890.273358992210874-0.120885980409131

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC1.05572772584878e-430.6817039943872662.8223020962445e-720.8065041101497250.510262004440737-0.037534749550448
AC1.32820046622717e-520.7809290111981864.9568492342851e-490.7636549346722569.34129038513892e-080.329830235427999
PCC5.84844343363801e-280.6865148939521963.64525620397059e-390.7727414729107690.8233939867454580.0162545034306519
CER8.17415384974397e-060.3552256913337349.10678686079727e-070.3883045377067360.03123951908034390.175971326027641
TCX1.11482665415286e-200.6673248350581031.00346749742399e-210.6803993866753550.0232346121107907-0.185251116120488
FP7.89999461433865e-050.291474318976743.580202068825e-140.5281000076712610.0414073566971452-0.153038119976464
IFG0.003644414796195080.5594120168148020.02441711818131070.4488261504960380.0884709233892509-0.347779644327359
PG2.7911856351734e-390.7798189308070447.69124446358702e-300.7100493506075860.0609836118871945-0.13765331296774
STG3.99471144746618e-080.5560461731699064.7426134536729e-160.7445549326744660.0391811044926322-0.225485174073029

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Relation with AD stages for GLRX2

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
STGADediting_52977chr1_193095839_-0.00465799879221548-0.305899835501922

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.

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RelatedDrugs for GLRX2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
GLRX2Q9NS18DB00143GlutathioneGlutaredoxin-2, mitochondrialsmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for GLRX2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource