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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for WASHC3

check button Gene summary
Gene informationGene symbol

WASHC3

Gene ID

51019

Gene nameWASH complex subunit 3
SynonymsCCDC53|CGI-116
Cytomap

12q23.2

Type of geneprotein-coding
DescriptionWASH complex subunit 3WASH complex subunit CCDC53coiled-coil domain containing 53coiled-coil domain-containing protein 53
Modification date20200327
UniProtAcc

Q9Y3C0,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for WASHC3

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_294691(102014143, -), ADediting_294692(102014150, -), ADediting_294693(102014159, -), ADediting_294694(102014179, -), ADediting_294695(102014180, -), ADediting_294696(102014193, -), ADediting_294697(102014237, -), ADediting_294698(102014291, -), ADediting_294699(102014292, -), ADediting_294700(102014346, -), ADediting_294701(102015040, -), ADediting_294702(102015111, -), ADediting_294703(102015137, -), ADediting_294704(102015172, -), ADediting_294705(102015184, -), ADediting_294706(102015188, -), ADediting_294707(102015203, -), ADediting_294708(102015209, -), ADediting_294709(102015210, -), ADediting_294710(102015216, -), ADediting_294711(102015229, -), ADediting_294712(102015239, -), ADediting_294713(102015241, -), ADediting_294714(102015247, -), ADediting_294715(102015277, -), ADediting_294716(102015285, -), ADediting_294717(102015289, -), ADediting_294718(102015975, -), ADediting_294719(102015979, -), ADediting_294720(102015980, -), ADediting_294721(102015982, -), ADediting_294722(102015986, -), ADediting_294723(102015987, -), ADediting_294724(102016014, -), ADediting_294725(102016072, -), ADediting_294726(102016329, -), ADediting_294727(102016464, -), ADediting_294728(102016478, -), ADediting_294729(102016484, -), ADediting_294730(102018551, -), ADediting_294731(102018565, -), ADediting_294732(102018570, -), ADediting_294733(102018575, -), ADediting_294734(102018588, -), ADediting_294735(102018589, -), ADediting_294736(102018604, -), ADediting_294737(102018611, -), ADediting_294738(102018624, -), ADediting_294739(102018637, -), ADediting_294740(102018670, -), ADediting_294741(102018687, -), ADediting_294742(102018701, -), ADediting_294743(102018893, -), ADediting_294744(102018902, -), ADediting_294745(102018913, -), ADediting_294746(102018914, -), ADediting_294747(102018922, -), ADediting_294748(102018933, -), ADediting_294749(102018936, -), ADediting_294750(102018965, -), ADediting_294751(102018968, -), ADediting_294752(102018969, -), ADediting_294753(102018971, -), ADediting_294754(102019002, -), ADediting_294755(102019071, -), ADediting_294756(102019072, -), ADediting_294757(102020045, -), ADediting_294758(102020809, -), ADediting_294759(102020825, -), ADediting_294760(102020837, -), ADediting_294761(102020838, -), ADediting_294762(102020890, -), ADediting_294763(102020973, -), ADediting_294764(102020982, -), ADediting_294765(102020995, -), ADediting_294766(102020999, -), ADediting_294767(102021000, -), ADediting_294768(102021019, -), ADediting_294769(102021025, -), ADediting_294770(102021035, -), ADediting_294771(102021380, -), ADediting_294772(102036286, -), ADediting_294773(102039083, -), ADediting_294774(102050192, -), ADediting_294775(102050257, -), ADediting_294776(102050281, -), ADediting_294777(102050289, -), ADediting_294778(102050621, -), ADediting_1529489(102015156, -), ADediting_1529490(102015234, -), ADediting_1529491(102015950, -), ADediting_1529492(102015957, -), ADediting_1529493(102016477, -), ADediting_1529494(102018669, -), ADediting_1529495(102018697, -), ADediting_1529496(102018721, -), ADediting_1529497(102018742, -), ADediting_1529498(102018926, -), ADediting_1529499(102018966, -), ADediting_1529500(102050548, -), ADediting_1529501(102050560, -), ADediting_1529502(102050561, -),

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RNA editing positional annotations for WASHC3 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
ADediting_1529501chr12_102050560_-nonsynonymous SNVENST00000500685.6c.A230Gp.K77R...
ADediting_1529502chr12_102050561_-nonsynonymous SNVENST00000500685.6c.A229Gp.K77E...
ADediting_294775chr12_102050257_-stoplossENST00000535501.5c.A185Gp.X62W...
ADediting_294776chr12_102050281_-nonsynonymous SNVENST00000535501.5c.A161Gp.H54R...
ADediting_294777chr12_102050289_-synonymous SNVENST00000535501.5c.A153Gp.T51T...
ADediting_294778chr12_102050621_-nonsynonymous SNVENST00000500685.6c.A169Gp.T57A...

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_294691chr12_102014143_-intronic
ADediting_294692chr12_102014150_-intronic
ADediting_294693chr12_102014159_-intronic
ADediting_294694chr12_102014179_-intronic
ADediting_294695chr12_102014180_-intronic
ADediting_294696chr12_102014193_-intronic
ADediting_294697chr12_102014237_-intronic
ADediting_294698chr12_102014291_-intronic
ADediting_294699chr12_102014292_-intronic
ADediting_294700chr12_102014346_-intronic
ADediting_294701chr12_102015040_-intronic
ADediting_294702chr12_102015111_-intronic
ADediting_294703chr12_102015137_-intronic
ADediting_294704chr12_102015172_-intronic
ADediting_294705chr12_102015184_-intronic
ADediting_294706chr12_102015188_-intronic
ADediting_294707chr12_102015203_-intronic
ADediting_294708chr12_102015209_-intronic
ADediting_294709chr12_102015210_-intronic
ADediting_294710chr12_102015216_-intronic
ADediting_294711chr12_102015229_-intronic
ADediting_294712chr12_102015239_-intronic
ADediting_294713chr12_102015241_-intronic
ADediting_294714chr12_102015247_-intronic
ADediting_294715chr12_102015277_-intronic
ADediting_294716chr12_102015285_-intronic
ADediting_294717chr12_102015289_-intronic
ADediting_294718chr12_102015975_-intronic
ADediting_294719chr12_102015979_-intronic
ADediting_294720chr12_102015980_-intronic
ADediting_294721chr12_102015982_-intronic
ADediting_294722chr12_102015986_-intronic
ADediting_294723chr12_102015987_-intronic
ADediting_294724chr12_102016014_-intronic
ADediting_294725chr12_102016072_-intronic
ADediting_294726chr12_102016329_-intronic
ADediting_294727chr12_102016464_-intronic
ADediting_294728chr12_102016478_-intronic
ADediting_294729chr12_102016484_-intronic
ADediting_294730chr12_102018551_-intronic
ADediting_294731chr12_102018565_-intronic
ADediting_294732chr12_102018570_-intronic
ADediting_294733chr12_102018575_-intronic
ADediting_294734chr12_102018588_-intronic
ADediting_294735chr12_102018589_-intronic
ADediting_294736chr12_102018604_-intronic
ADediting_294737chr12_102018611_-intronic
ADediting_294738chr12_102018624_-intronic
ADediting_294739chr12_102018637_-intronic
ADediting_294740chr12_102018670_-intronic
ADediting_294741chr12_102018687_-intronic
ADediting_294742chr12_102018701_-intronic
ADediting_294743chr12_102018893_-intronic
ADediting_294744chr12_102018902_-intronic
ADediting_294745chr12_102018913_-intronic
ADediting_294746chr12_102018914_-intronic
ADediting_294747chr12_102018922_-intronic
ADediting_294748chr12_102018933_-intronic
ADediting_294749chr12_102018936_-intronic
ADediting_294750chr12_102018965_-intronic
ADediting_294751chr12_102018968_-intronic
ADediting_294752chr12_102018969_-intronic
ADediting_294753chr12_102018971_-intronic
ADediting_294754chr12_102019002_-intronic
ADediting_294755chr12_102019071_-intronic
ADediting_294756chr12_102019072_-intronic
ADediting_294757chr12_102020045_-intronic
ADediting_294758chr12_102020809_-intronic
ADediting_294759chr12_102020825_-intronic
ADediting_294760chr12_102020837_-intronic
ADediting_294761chr12_102020838_-intronic
ADediting_294762chr12_102020890_-intronic
ADediting_294763chr12_102020973_-intronic
ADediting_294764chr12_102020982_-intronic
ADediting_294765chr12_102020995_-intronic
ADediting_294766chr12_102020999_-intronic
ADediting_294767chr12_102021000_-intronic
ADediting_294768chr12_102021019_-intronic
ADediting_294769chr12_102021025_-intronic
ADediting_294770chr12_102021035_-intronic
ADediting_294771chr12_102021380_-intronic
ADediting_294772chr12_102036286_-intronic
ADediting_294773chr12_102039083_-intronic
ADediting_294774chr12_102050192_-UTR3
ADediting_294775chr12_102050257_-exonic
ADediting_294776chr12_102050281_-exonic
ADediting_294777chr12_102050289_-exonic
ADediting_294778chr12_102050621_-exonic
ADediting_1529489chr12_102015156_-intronic
ADediting_1529490chr12_102015234_-intronic
ADediting_1529491chr12_102015950_-intronic
ADediting_1529492chr12_102015957_-intronic
ADediting_1529493chr12_102016477_-intronic
ADediting_1529494chr12_102018669_-intronic
ADediting_1529495chr12_102018697_-intronic
ADediting_1529496chr12_102018721_-intronic
ADediting_1529497chr12_102018742_-intronic
ADediting_1529498chr12_102018926_-intronic
ADediting_1529499chr12_102018966_-intronic
ADediting_1529500chr12_102050548_-UTR3
ADediting_1529501chr12_102050560_-exonic
ADediting_1529502chr12_102050561_-exonic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_294691chr12_102014143_-SINEAluName=AluSc
ADediting_294692chr12_102014150_-SINEAluName=AluSc
ADediting_294693chr12_102014159_-SINEAluName=AluSc
ADediting_294694chr12_102014179_-SINEAluName=AluSc
ADediting_294695chr12_102014180_-SINEAluName=AluSc
ADediting_294696chr12_102014193_-SINEAluName=AluSc
ADediting_294697chr12_102014237_-SINEAluName=AluSc
ADediting_294698chr12_102014291_-SINEAluName=AluSc
ADediting_294699chr12_102014292_-SINEAluName=AluSc
ADediting_294700chr12_102014346_-SINEAluName=AluSc
ADediting_294701chr12_102015040_-SINEAluName=AluJb
ADediting_294702chr12_102015111_-SINEAluName=AluJb
ADediting_294703chr12_102015137_-SINEAluName=AluJb
ADediting_294704chr12_102015172_-SINEAluName=AluJb
ADediting_294705chr12_102015184_-SINEAluName=AluJb
ADediting_294706chr12_102015188_-SINEAluName=AluJb
ADediting_294707chr12_102015203_-SINEAluName=AluJb
ADediting_294708chr12_102015209_-SINEAluName=AluJb
ADediting_294709chr12_102015210_-SINEAluName=AluJb
ADediting_294710chr12_102015216_-SINEAluName=AluJb
ADediting_294711chr12_102015229_-SINEAluName=AluJb
ADediting_294712chr12_102015239_-SINEAluName=AluJb
ADediting_294713chr12_102015241_-SINEAluName=AluJb
ADediting_294714chr12_102015247_-SINEAluName=AluJb
ADediting_294715chr12_102015277_-SINEAluName=AluJb
ADediting_294716chr12_102015285_-SINEAluName=AluJb
ADediting_294717chr12_102015289_-SINEAluName=AluJb
ADediting_294718chr12_102015975_-SINEAluName=AluSz
ADediting_294719chr12_102015979_-SINEAluName=AluSz
ADediting_294720chr12_102015980_-SINEAluName=AluSz
ADediting_294721chr12_102015982_-SINEAluName=AluSz
ADediting_294722chr12_102015986_-SINEAluName=AluSz
ADediting_294723chr12_102015987_-SINEAluName=AluSz
ADediting_294724chr12_102016014_-SINEAluName=AluSz
ADediting_294725chr12_102016072_-SINEAluName=AluSz
ADediting_294726chr12_102016329_-SINEAluName=AluSx
ADediting_294727chr12_102016464_-SINEAluName=AluSx
ADediting_294728chr12_102016478_-SINEAluName=AluSx
ADediting_294729chr12_102016484_-SINEAluName=AluSx
ADediting_294730chr12_102018551_-SINEAluName=AluJr4
ADediting_294731chr12_102018565_-SINEAluName=AluJr4
ADediting_294732chr12_102018570_-SINEAluName=AluJr4
ADediting_294733chr12_102018575_-SINEAluName=AluJr4
ADediting_294734chr12_102018588_-SINEAluName=AluJr4
ADediting_294735chr12_102018589_-SINEAluName=AluJr4
ADediting_294736chr12_102018604_-SINEAluName=AluJr4
ADediting_294737chr12_102018611_-SINEAluName=AluJr4
ADediting_294738chr12_102018624_-SINEAluName=AluJr4
ADediting_294739chr12_102018637_-SINEAluName=AluJr4
ADediting_294740chr12_102018670_-SINEAluName=AluJr4
ADediting_294741chr12_102018687_-SINEAluName=AluJr4
ADediting_294742chr12_102018701_-SINEAluName=AluJr4
ADediting_294743chr12_102018893_-SINEAluName=AluSx
ADediting_294744chr12_102018902_-SINEAluName=AluSx
ADediting_294745chr12_102018913_-SINEAluName=AluSx
ADediting_294746chr12_102018914_-SINEAluName=AluSx
ADediting_294747chr12_102018922_-SINEAluName=AluSx
ADediting_294748chr12_102018933_-SINEAluName=AluSx
ADediting_294749chr12_102018936_-SINEAluName=AluSx
ADediting_294750chr12_102018965_-SINEAluName=AluSx
ADediting_294751chr12_102018968_-SINEAluName=AluSx
ADediting_294752chr12_102018969_-SINEAluName=AluSx
ADediting_294753chr12_102018971_-SINEAluName=AluSx
ADediting_294754chr12_102019002_-SINEAluName=AluSx
ADediting_294755chr12_102019071_-SINEAluName=AluSx
ADediting_294756chr12_102019072_-SINEAluName=AluSx
ADediting_294757chr12_102020045_-LTRERVL-MaLRName=MLT1K
ADediting_294758chr12_102020809_-SINEAluName=AluSq2
ADediting_294759chr12_102020825_-SINEAluName=AluSq2
ADediting_294760chr12_102020837_-SINEAluName=AluSq2
ADediting_294761chr12_102020838_-SINEAluName=AluSq2
ADediting_294762chr12_102020890_-SINEAluName=AluSq2
ADediting_294763chr12_102020973_-SINEAluName=AluSq2
ADediting_294764chr12_102020982_-SINEAluName=AluSq2
ADediting_294765chr12_102020995_-SINEAluName=AluSq2
ADediting_294766chr12_102020999_-SINEAluName=AluSq2
ADediting_294767chr12_102021000_-SINEAluName=AluSq2
ADediting_294768chr12_102021019_-SINEAluName=AluSq2
ADediting_294769chr12_102021025_-SINEAluName=AluSq2
ADediting_294770chr12_102021035_-SINEAluName=AluSq2
ADediting_294772chr12_102036286_-SINEAluName=AluSq2
ADediting_294773chr12_102039083_-SINEAluName=AluJr
ADediting_294774chr12_102050192_-SINEAluName=AluJo
ADediting_294775chr12_102050257_-SINEAluName=AluJo
ADediting_294776chr12_102050281_-SINEAluName=AluJo
ADediting_294777chr12_102050289_-SINEAluName=AluJo
ADediting_294778chr12_102050621_-SINEAluName=AluJb
ADediting_1529489chr12_102015156_-SINEAluName=AluJb
ADediting_1529490chr12_102015234_-SINEAluName=AluJb
ADediting_1529491chr12_102015950_-SINEAluName=AluSz
ADediting_1529492chr12_102015957_-SINEAluName=AluSz
ADediting_1529493chr12_102016477_-SINEAluName=AluSx
ADediting_1529494chr12_102018669_-SINEAluName=AluJr4
ADediting_1529495chr12_102018697_-SINEAluName=AluJr4
ADediting_1529496chr12_102018721_-SINEAluName=AluJr4
ADediting_1529497chr12_102018742_-SINEAluName=AluJr4
ADediting_1529498chr12_102018926_-SINEAluName=AluSx
ADediting_1529499chr12_102018966_-SINEAluName=AluSx
ADediting_1529500chr12_102050548_-SINEAluName=AluJb
ADediting_1529501chr12_102050560_-SINEAluName=AluJb
ADediting_1529502chr12_102050561_-SINEAluName=AluJb

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RNA A-to-I editing events in the alternative splicing sites for WASHC3

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
A3SSADediting_294777chr12_102050289_-102050285:1020503073ss2iGTTGTTTTTTTGTCAGACAGGGT2.44GTTGTTTTTTTGTCAGACGGGGT-5.51
ESADediting_294777chr12_102050289_-102050285:1020503073ss2iGTTGTTTTTTTGTCAGACAGGGT2.44GTTGTTTTTTTGTCAGACGGGGT-5.51
ESADediting_294777chr12_102050289_-102050289:1020503113ss3eTTTTGTTGTTTTTTTGTCAGACA6.63TTTTGTTGTTTTTTTGTCAGACG6.46
ME2ADediting_294777chr12_102050289_-102050289:1020503113ss3eTTTTGTTGTTTTTTTGTCAGACA6.63TTTTGTTGTTTTTTTGTCAGACG6.46

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for WASHC3

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for WASHC3

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
all structure


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The effects of the RNA editing to the miRNA binding sites for WASHC3

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_294774chr12_102050192_-ENSG00000120860.11ENST00000539515.5WASHC3-208hsa-miR-17-3pchr121020461191020501958mer-1a102046119102050210158-21.55
ADediting_294774chr12_102050192_-ENSG00000120860.11ENST00000539515.5WASHC3-208hsa-miR-544achr121020461171020501938mer-1a102046117102050207168-16.98
ADediting_294774chr12_102050192_-ENSG00000120860.11ENST00000539515.5WASHC3-208hsa-miR-584-3pchr121020501921020501987mer-m8102050191102050210153-18.22
ADediting_294777chr12_102050289_-ENSG00000120860.11ENST00000539515.5WASHC3-208hsa-miR-340-3pchr121020502881020612507mer-m8102050287102061263144-18.27
ADediting_294777chr12_102050289_-ENSG00000120860.11ENST00000539515.5WASHC3-208hsa-miR-6827-3pchr121020502881020612507mer-m8102050287102061263151-18.24

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_294776chr12_102050281_-ENSG00000120860.11ENST00000539515.5WASHC3-208hsa-miR-3609chr121020502771020502837mer-m8102050276102061254141-15.75
ADediting_294776chr12_102050281_-ENSG00000120860.11ENST00000539515.5WASHC3-208hsa-miR-520g-3pchr121020502761020502827mer-m8102050275102061254153-17.57
ADediting_294776chr12_102050281_-ENSG00000120860.11ENST00000539515.5WASHC3-208hsa-miR-520hchr121020502761020502827mer-m8102050275102061252153-17.57
ADediting_294776chr12_102050281_-ENSG00000120860.11ENST00000539515.5WASHC3-208hsa-miR-548ah-5pchr121020502771020502837mer-m8102050276102061250144-12.12
ADediting_294777chr12_102050289_-ENSG00000120860.11ENST00000539515.5WASHC3-208hsa-miR-10a-5pchr121020502851020502917mer-m8102050284102061264145-20.5
ADediting_294777chr12_102050289_-ENSG00000120860.11ENST00000539515.5WASHC3-208hsa-miR-10b-5pchr121020502851020502917mer-m8102050284102061262140-16.3
ADediting_294777chr12_102050289_-ENSG00000120860.11ENST00000539515.5WASHC3-208hsa-miR-4421chr121020502871020612497mer-m8102050286102061263141-16.59
ADediting_294777chr12_102050289_-ENSG00000120860.11ENST00000539515.5WASHC3-208hsa-miR-4725-5pchr121020502841020502907mer-m8102050283102061259151-22.31
ADediting_294777chr12_102050289_-ENSG00000120860.11ENST00000539515.5WASHC3-208hsa-miR-504-5pchr121020502841020502907mer-m8102050283102061259154-22.08
ADediting_294777chr12_102050289_-ENSG00000120860.11ENST00000539515.5WASHC3-208hsa-miR-5699-3pchr121020502871020612497mer-m8102050286102061265146-20.59

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1556067chr19_40282625_-ENSG00000120860.11ENST00000240079.11WASHC3-201hsa-miR-641chr121020129331020129397mer-m8102012932102012955149-12.23
ADediting_1631458chr19_40282624_-ENSG00000120860.11ENST00000240079.11WASHC3-201hsa-miR-641chr121020129331020129397mer-m8102012932102012955149-12.23

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for WASHC3

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000539515.5lncRNASoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_294774ENST00000539515.5chr12_102050192_-243-183.50-183.80-186.60
ADediting_294775ENST00000539515.5chr12_102050257_-178-187.40-183.80-186.60
ADediting_294776ENST00000539515.5chr12_102050281_-154-184.10-183.80-186.60
ADediting_294777ENST00000539515.5chr12_102050289_-146-183.00-183.80-186.60

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Relation with ADAR for WASHC3

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_294699chr12_102014292_-0.008553930028040430.1491057006669480.2975760296481260.05934908535596974.6299961593224e-080.304229939984391
TCXADediting_294700chr12_102014346_-0.2235575726287250.09996476224260940.0651889407972135-0.1509575561511572.12220984602138e-070.408417764934546
TCXADediting_294704chr12_102015172_-0.5813448029116080.04537979061503680.156537007979131-0.116262365060894.26684892622822e-050.327624581736359
DLPFCADediting_294708chr12_102015209_-1.26146490625087e-080.3161858464052258.92083227533314e-050.2206812766221132.51079754069678e-100.349338616509525
DLPFCADediting_294710chr12_102015216_-3.8811890888771e-060.2588275846286420.002383378069166690.1719414878853948.92292740672148e-090.319282161578338
DLPFCADediting_294712chr12_102015239_-1.87152820868253e-080.3126144474100516.72236387616697e-060.2525755276384631.30565697078347e-070.294297257524101
TCXADediting_294712chr12_102015239_-0.06893298603441460.1489257308731770.249688248685683-0.09456778995072881.20195683718707e-070.415923048139019
DLPFCADediting_294716chr12_102015285_-0.00018687169936910.2106629911329490.0262042580096340.1262719282575821.77528265825565e-080.313095170677376
DLPFCADediting_294719chr12_102015979_-0.001160566962261290.1836666509399820.1195460040861110.08859756228700255.60551296240721e-090.323384922028782
DLPFCADediting_294721chr12_102015982_-0.05136783346258150.1107680647579520.756076322046801-0.01771318914919272.18182793696799e-100.350457412389283
DLPFCADediting_294722chr12_102015986_-0.0002078038067162320.2091856854009040.1270930249288570.08683905820213585.89309943565941e-110.360679551890534
TCXADediting_294722chr12_102015986_-0.2283443241251040.09894417795266820.0675385030420803-0.1496717361902232.37718152360037e-080.43636664293146
DLPFCADediting_294723chr12_102015987_-0.002646383945201040.1701743706467470.2788700109237580.06169301073793811.43022382058155e-100.353795660639212
TCXADediting_294723chr12_102015987_-0.2529939209100670.09391353309877140.271504624534479-0.09035437823424466.16881889427815e-060.359678710926043
DLPFCADediting_294725chr12_102016072_-0.007769229025195860.1509305744564780.603100671654910.02964425698612175.59010570534338e-180.464288755212328
TCXADediting_294725chr12_102016072_-0.006073961727760480.2230633424863580.8913400254399370.01124780176644696.42017364014767e-060.359050929741079
DLPFCADediting_294727chr12_102016464_-4.22941494112252e-060.2578602223829190.06533650443427550.1048073974880396.05927694240928e-130.393831772052893
TCXADediting_294727chr12_102016464_-0.3643207151073980.07459026558256190.0257189371402307-0.1821116020221734.06227761525856e-070.399615233119687
TCXADediting_294731chr12_102018565_-0.2222223940888690.1002521894414080.104662342960014-0.1330128622268871.03064325062302e-060.386532901510742
TCXADediting_294732chr12_102018570_-0.5617948628991380.04774367324771380.046131278244083-0.163097379481711.00433033851301e-050.351924773287204
DLPFCADediting_294733chr12_102018575_-0.01059737684777860.1449721745984660.8766242654226990.00885319703566121.38267689144973e-230.527315244873692
TCXADediting_294733chr12_102018575_-0.1675572489113930.1132688776345490.0322222502963494-0.1749767922118481.01432273487507e-110.51902608707642
DLPFCADediting_294735chr12_102018589_-0.032728720895540.1213240754498860.9899785695111640.0007162723279370971.51468016735033e-130.40317833368981
TCXADediting_294735chr12_102018589_-0.008032740116522740.2156788583345780.247378903658161-0.09502841594361721.09822097481332e-090.471798294183597
TCXADediting_294737chr12_102018611_-0.004860256646851380.2287937600328820.87876925243488-0.01255855627925572.17276553870192e-070.408102968285069
TCXADediting_294739chr12_102018637_-0.01792873412065990.1930648871697670.382436048162837-0.07182284071756116.41828885062274e-100.477593374059924
TCXADediting_294746chr12_102018914_-0.0451959314008730.1637941561546040.240593102171436-0.09639942835419574.37978145338901e-090.456356169022215
TCXADediting_294747chr12_102018922_-0.04148822118453060.1666805048243460.333967584382795-0.07942579309090484.24801061298816e-070.398999705738613
DLPFCADediting_294760chr12_102020837_-4.88053859599061e-050.2285284707349980.008778294948933170.1486113520964052.07970346445733e-080.311651532676398
TCXADediting_294760chr12_102020837_-0.122652203986680.1265969020524750.4301086101839-0.06489699831703334.17133457022187e-080.429425323040254
DLPFCADediting_294764chr12_102020982_-0.006777701543866180.1534876533460380.5684449171594760.03251610945824453.82062406667558e-210.501457654445995
DLPFCADediting_294766chr12_102020999_-0.006966543199330680.1529759599481440.3605611377050710.05210374965460867.85419548646755e-150.422202023824709
DLPFCADediting_294767chr12_102021000_-0.002595201840382640.1705053340833240.2279050594682070.06867985935692288.28329004915815e-140.407157422751593
DLPFCADediting_294768chr12_102021019_-0.0003413249017339350.2021412921427350.03085741454120560.1226498319033466.45692717533432e-090.322143463009581
DLPFCADediting_294770chr12_102021035_-0.0003088922827184670.2035776368477640.06636600598971350.1044112042859247.66810074832573e-140.407662400093339

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC4.92715697790733e-360.6324336611242739.14929698476007e-410.6639113208335950.8032509818927670.0142069904253742
AC6.10842507106017e-760.8642048562518882.29686595420014e-490.7653361279880727.9564917448893e-160.480199180316471
PCC5.18736328157967e-230.6356380156502474.60670521970197e-240.6473040854364320.01190472168711210.181651695359944
CER9.14265346433705e-080.4194706182665310.009397171460159390.2114308279418950.01015188015387640.209310372049125
TCX2.1580140431736e-210.6763136296530611.1947897145121e-050.3491122618102540.0002117430345799150.298065939551789
FP6.78771289036938e-160.5570103636283051.07673855473928e-200.6252110842927410.2750709873432190.0822490789663649
IFG0.003246235683684980.5650956691653990.03941772999088220.4144426227910740.9338645633392680.0174909833931678
PG4.34825256960472e-490.8325856985026531.47714569432769e-210.6251143823968870.5978625022692410.0389242155833896
STG3.7704384428268e-190.7905906982916931.1973772542901e-100.6314377712140540.2569659548885370.125072639784341

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Relation with AD stages for WASHC3

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
TCXADediting_294700chr12_102014346_-0.0009390708564106320.316757877459564
TCXADediting_294739chr12_102018637_-0.0004498914176384040.33489273937538

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
IFG0.0274369899377173-0.440753114038182
STG0.00311940501795125-0.31881213843159

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RelatedDrugs for WASHC3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WASHC3

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource