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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for AMDHD2 |
 Gene summary |
| Gene information | Gene symbol | AMDHD2 | Gene ID | 51005 |
| Gene name | amidohydrolase domain containing 2 | |
| Synonyms | CGI-14 | |
| Cytomap | 16p13.3 | |
| Type of gene | protein-coding | |
| Description | N-acetylglucosamine-6-phosphate deacetylaseamidohydrolase domain-containing protein 2glcNAc 6-P deacetylaseputative N-acetylglucosamine-6-phosphate deacetylase | |
| Modification date | 20200327 | |
| UniProtAcc | Q9Y303, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for AMDHD2 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_530177(2521848, +), ADediting_530178(2522058, +), ADediting_530179(2522137, +), ADediting_530180(2522153, +), ADediting_530181(2522163, +), ADediting_530182(2522183, +), ADediting_530183(2522184, +), ADediting_530184(2522213, +), ADediting_530185(2522217, +), ADediting_530186(2522223, +), ADediting_530187(2522267, +), ADediting_530188(2522347, +), ADediting_530189(2522357, +), ADediting_530190(2522375, +), ADediting_530191(2522428, +), ADediting_530192(2522449, +), ADediting_530193(2522462, +), ADediting_530194(2522490, +), ADediting_530195(2522494, +), ADediting_530196(2522511, +), ADediting_530197(2522530, +), ADediting_530198(2522556, +), ADediting_530199(2522579, +), ADediting_530200(2522583, +), ADediting_530201(2522586, +), ADediting_530202(2522598, +), ADediting_530203(2522697, +), ADediting_530204(2522703, +), ADediting_530205(2522715, +), ADediting_530206(2522743, +), ADediting_530208(2522918, +), ADediting_530209(2522921, +), ADediting_530210(2522923, +), ADediting_530211(2522943, +), ADediting_530212(2522944, +), ADediting_530213(2522961, +), ADediting_530214(2522973, +), ADediting_530215(2522983, +), ADediting_530216(2523009, +), ADediting_530217(2523010, +), ADediting_530218(2523018, +), ADediting_530219(2523024, +), ADediting_530220(2523027, +), ADediting_530221(2523046, +), ADediting_530222(2523053, +), ADediting_530223(2523078, +), ADediting_530224(2523081, +), ADediting_530225(2523094, +), ADediting_530226(2523104, +), ADediting_530227(2523110, +), ADediting_530228(2523116, +), ADediting_530232(2525137, +), ADediting_530233(2525157, +), ADediting_530234(2525174, +), ADediting_530235(2525196, +), ADediting_530236(2525241, +), ADediting_530237(2525267, +), ADediting_530238(2525657, +), ADediting_530239(2525888, +), ADediting_530272(2526660, +), ADediting_530273(2526682, +), ADediting_530274(2526683, +), ADediting_530275(2526688, +), ADediting_530276(2526704, +), ADediting_530277(2526731, +), ADediting_530278(2526741, +), ADediting_530279(2526755, +), ADediting_530280(2526766, +), ADediting_530281(2526769, +), ADediting_530282(2526770, +), ADediting_530283(2526771, +), ADediting_530284(2526772, +), ADediting_530285(2526778, +), ADediting_530286(2526783, +), ADediting_530287(2526809, +), ADediting_530288(2526810, +), ADediting_530289(2526836, +), ADediting_530290(2526839, +), ADediting_530291(2526842, +), ADediting_530292(2526850, +), ADediting_530293(2526851, +), ADediting_530294(2526855, +), ADediting_530295(2526858, +), ADediting_530296(2526862, +), ADediting_530297(2526920, +), ADediting_1541646(2522107, +), ADediting_1541647(2522225, +), ADediting_1541648(2522249, +), ADediting_1541649(2522250, +), ADediting_1541650(2522273, +), ADediting_1541651(2525332, +), ADediting_1541652(2525638, +), ADediting_1541656(2526780, +), |
Top |
RNA editing positional annotations for AMDHD2 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_530177 | chr16_2521848_+ | intronic |
| ADediting_530178 | chr16_2522058_+ | intronic |
| ADediting_530179 | chr16_2522137_+ | intronic |
| ADediting_530180 | chr16_2522153_+ | intronic |
| ADediting_530181 | chr16_2522163_+ | intronic |
| ADediting_530182 | chr16_2522183_+ | intronic |
| ADediting_530183 | chr16_2522184_+ | intronic |
| ADediting_530184 | chr16_2522213_+ | intronic |
| ADediting_530185 | chr16_2522217_+ | intronic |
| ADediting_530186 | chr16_2522223_+ | intronic |
| ADediting_530187 | chr16_2522267_+ | intronic |
| ADediting_530188 | chr16_2522347_+ | intronic |
| ADediting_530189 | chr16_2522357_+ | intronic |
| ADediting_530190 | chr16_2522375_+ | intronic |
| ADediting_530191 | chr16_2522428_+ | intronic |
| ADediting_530192 | chr16_2522449_+ | intronic |
| ADediting_530193 | chr16_2522462_+ | intronic |
| ADediting_530194 | chr16_2522490_+ | intronic |
| ADediting_530195 | chr16_2522494_+ | intronic |
| ADediting_530196 | chr16_2522511_+ | intronic |
| ADediting_530197 | chr16_2522530_+ | intronic |
| ADediting_530198 | chr16_2522556_+ | intronic |
| ADediting_530199 | chr16_2522579_+ | intronic |
| ADediting_530200 | chr16_2522583_+ | intronic |
| ADediting_530201 | chr16_2522586_+ | intronic |
| ADediting_530202 | chr16_2522598_+ | intronic |
| ADediting_530203 | chr16_2522697_+ | intronic |
| ADediting_530204 | chr16_2522703_+ | intronic |
| ADediting_530205 | chr16_2522715_+ | intronic |
| ADediting_530206 | chr16_2522743_+ | intronic |
| ADediting_530208 | chr16_2522918_+ | intronic |
| ADediting_530209 | chr16_2522921_+ | intronic |
| ADediting_530210 | chr16_2522923_+ | intronic |
| ADediting_530211 | chr16_2522943_+ | intronic |
| ADediting_530212 | chr16_2522944_+ | intronic |
| ADediting_530213 | chr16_2522961_+ | intronic |
| ADediting_530214 | chr16_2522973_+ | intronic |
| ADediting_530215 | chr16_2522983_+ | intronic |
| ADediting_530216 | chr16_2523009_+ | intronic |
| ADediting_530217 | chr16_2523010_+ | intronic |
| ADediting_530218 | chr16_2523018_+ | intronic |
| ADediting_530219 | chr16_2523024_+ | intronic |
| ADediting_530220 | chr16_2523027_+ | intronic |
| ADediting_530221 | chr16_2523046_+ | intronic |
| ADediting_530222 | chr16_2523053_+ | intronic |
| ADediting_530223 | chr16_2523078_+ | intronic |
| ADediting_530224 | chr16_2523081_+ | intronic |
| ADediting_530225 | chr16_2523094_+ | intronic |
| ADediting_530226 | chr16_2523104_+ | intronic |
| ADediting_530227 | chr16_2523110_+ | intronic |
| ADediting_530228 | chr16_2523116_+ | intronic |
| ADediting_530232 | chr16_2525137_+ | intronic |
| ADediting_530233 | chr16_2525157_+ | intronic |
| ADediting_530234 | chr16_2525174_+ | intronic |
| ADediting_530235 | chr16_2525196_+ | intronic |
| ADediting_530236 | chr16_2525241_+ | intronic |
| ADediting_530237 | chr16_2525267_+ | intronic |
| ADediting_530238 | chr16_2525657_+ | intronic |
| ADediting_530239 | chr16_2525888_+ | intronic |
| ADediting_530272 | chr16_2526660_+ | intronic |
| ADediting_530273 | chr16_2526682_+ | intronic |
| ADediting_530274 | chr16_2526683_+ | intronic |
| ADediting_530275 | chr16_2526688_+ | intronic |
| ADediting_530276 | chr16_2526704_+ | intronic |
| ADediting_530277 | chr16_2526731_+ | intronic |
| ADediting_530278 | chr16_2526741_+ | intronic |
| ADediting_530279 | chr16_2526755_+ | intronic |
| ADediting_530280 | chr16_2526766_+ | intronic |
| ADediting_530281 | chr16_2526769_+ | intronic |
| ADediting_530282 | chr16_2526770_+ | intronic |
| ADediting_530283 | chr16_2526771_+ | intronic |
| ADediting_530284 | chr16_2526772_+ | intronic |
| ADediting_530285 | chr16_2526778_+ | intronic |
| ADediting_530286 | chr16_2526783_+ | intronic |
| ADediting_530287 | chr16_2526809_+ | intronic |
| ADediting_530288 | chr16_2526810_+ | intronic |
| ADediting_530289 | chr16_2526836_+ | intronic |
| ADediting_530290 | chr16_2526839_+ | intronic |
| ADediting_530291 | chr16_2526842_+ | intronic |
| ADediting_530292 | chr16_2526850_+ | intronic |
| ADediting_530293 | chr16_2526851_+ | intronic |
| ADediting_530294 | chr16_2526855_+ | intronic |
| ADediting_530295 | chr16_2526858_+ | intronic |
| ADediting_530296 | chr16_2526862_+ | intronic |
| ADediting_530297 | chr16_2526920_+ | intronic |
| ADediting_1541646 | chr16_2522107_+ | intronic |
| ADediting_1541647 | chr16_2522225_+ | intronic |
| ADediting_1541648 | chr16_2522249_+ | intronic |
| ADediting_1541649 | chr16_2522250_+ | intronic |
| ADediting_1541650 | chr16_2522273_+ | intronic |
| ADediting_1541651 | chr16_2525332_+ | intronic |
| ADediting_1541652 | chr16_2525638_+ | intronic |
| ADediting_1541656 | chr16_2526780_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_530177 | chr16_2521848_+ | SINE | Alu | Name=AluYe5 |
| ADediting_530178 | chr16_2522058_+ | SINE | Alu | Name=AluYe5 |
| ADediting_530179 | chr16_2522137_+ | SINE | Alu | Name=AluJo |
| ADediting_530180 | chr16_2522153_+ | SINE | Alu | Name=AluJo |
| ADediting_530181 | chr16_2522163_+ | SINE | Alu | Name=AluJo |
| ADediting_530182 | chr16_2522183_+ | SINE | Alu | Name=AluJo |
| ADediting_530183 | chr16_2522184_+ | SINE | Alu | Name=AluJo |
| ADediting_530184 | chr16_2522213_+ | SINE | Alu | Name=AluJo |
| ADediting_530185 | chr16_2522217_+ | SINE | Alu | Name=AluJo |
| ADediting_530186 | chr16_2522223_+ | SINE | Alu | Name=AluJo |
| ADediting_530187 | chr16_2522267_+ | SINE | Alu | Name=AluJo |
| ADediting_530188 | chr16_2522347_+ | SINE | Alu | Name=AluJo |
| ADediting_530189 | chr16_2522357_+ | SINE | Alu | Name=AluJo |
| ADediting_530190 | chr16_2522375_+ | SINE | Alu | Name=AluJo |
| ADediting_530191 | chr16_2522428_+ | SINE | Alu | Name=AluSc8 |
| ADediting_530192 | chr16_2522449_+ | SINE | Alu | Name=AluSc8 |
| ADediting_530193 | chr16_2522462_+ | SINE | Alu | Name=AluSc8 |
| ADediting_530194 | chr16_2522490_+ | SINE | Alu | Name=AluSc8 |
| ADediting_530195 | chr16_2522494_+ | SINE | Alu | Name=AluSc8 |
| ADediting_530196 | chr16_2522511_+ | SINE | Alu | Name=AluSc8 |
| ADediting_530197 | chr16_2522530_+ | SINE | Alu | Name=AluSc8 |
| ADediting_530198 | chr16_2522556_+ | SINE | Alu | Name=AluSc8 |
| ADediting_530199 | chr16_2522579_+ | SINE | Alu | Name=AluSc8 |
| ADediting_530200 | chr16_2522583_+ | SINE | Alu | Name=AluSc8 |
| ADediting_530201 | chr16_2522586_+ | SINE | Alu | Name=AluSc8 |
| ADediting_530202 | chr16_2522598_+ | SINE | Alu | Name=AluSc8 |
| ADediting_530203 | chr16_2522697_+ | SINE | Alu | Name=AluJo |
| ADediting_530204 | chr16_2522703_+ | SINE | Alu | Name=AluJo |
| ADediting_530205 | chr16_2522715_+ | SINE | Alu | Name=AluJo |
| ADediting_530206 | chr16_2522743_+ | SINE | Alu | Name=AluJo |
| ADediting_530208 | chr16_2522918_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530209 | chr16_2522921_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530210 | chr16_2522923_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530211 | chr16_2522943_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530212 | chr16_2522944_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530213 | chr16_2522961_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530214 | chr16_2522973_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530215 | chr16_2522983_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530216 | chr16_2523009_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530217 | chr16_2523010_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530218 | chr16_2523018_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530219 | chr16_2523024_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530220 | chr16_2523027_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530221 | chr16_2523046_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530222 | chr16_2523053_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530223 | chr16_2523078_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530224 | chr16_2523081_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530225 | chr16_2523094_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530226 | chr16_2523104_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530227 | chr16_2523110_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530228 | chr16_2523116_+ | SINE | Alu | Name=AluSx4 |
| ADediting_530232 | chr16_2525137_+ | SINE | Alu | Name=AluSx1 |
| ADediting_530233 | chr16_2525157_+ | SINE | Alu | Name=AluSx1 |
| ADediting_530234 | chr16_2525174_+ | SINE | Alu | Name=AluSx1 |
| ADediting_530235 | chr16_2525196_+ | SINE | Alu | Name=AluSx1 |
| ADediting_530236 | chr16_2525241_+ | SINE | Alu | Name=AluSx1 |
| ADediting_530237 | chr16_2525267_+ | SINE | Alu | Name=AluSx1 |
| ADediting_530238 | chr16_2525657_+ | SINE | Alu | Name=AluY |
| ADediting_530239 | chr16_2525888_+ | SINE | Alu | Name=AluSp |
| ADediting_530272 | chr16_2526660_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530273 | chr16_2526682_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530274 | chr16_2526683_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530275 | chr16_2526688_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530276 | chr16_2526704_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530277 | chr16_2526731_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530278 | chr16_2526741_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530279 | chr16_2526755_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530280 | chr16_2526766_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530281 | chr16_2526769_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530282 | chr16_2526770_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530283 | chr16_2526771_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530284 | chr16_2526772_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530285 | chr16_2526778_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530286 | chr16_2526783_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530287 | chr16_2526809_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530288 | chr16_2526810_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530289 | chr16_2526836_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530290 | chr16_2526839_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530291 | chr16_2526842_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530292 | chr16_2526850_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530293 | chr16_2526851_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530294 | chr16_2526855_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530295 | chr16_2526858_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530296 | chr16_2526862_+ | SINE | Alu | Name=AluSq2 |
| ADediting_530297 | chr16_2526920_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1541646 | chr16_2522107_+ | SINE | Alu | Name=AluJo |
| ADediting_1541647 | chr16_2522225_+ | SINE | Alu | Name=AluJo |
| ADediting_1541648 | chr16_2522249_+ | SINE | Alu | Name=AluJo |
| ADediting_1541649 | chr16_2522250_+ | SINE | Alu | Name=AluJo |
| ADediting_1541650 | chr16_2522273_+ | SINE | Alu | Name=AluJo |
| ADediting_1541651 | chr16_2525332_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1541652 | chr16_2525638_+ | SINE | Alu | Name=AluY |
| ADediting_1541656 | chr16_2526780_+ | SINE | Alu | Name=AluSq2 |
Top |
RNA A-to-I editing events in the alternative splicing sites for AMDHD2 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for AMDHD2 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for AMDHD2 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for AMDHD2 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1391023 | chr8_140732605_- | ENSG00000162066.15 | ENST00000302956.8 | AMDHD2-202 | hsa-miR-151a-3p | chr16 | 2531129 | 2531135 | 7mer-m8 | 2531116 | 2531136 | 145 | -22.24 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000162066.15 | ENST00000648227.1 | AMDHD2-219 | hsa-miR-151a-3p | chr16 | 2531129 | 2531135 | 7mer-m8 | 2531116 | 2531136 | 145 | -22.24 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000162066.15 | ENST00000302956.8 | AMDHD2-202 | hsa-miR-641 | chr16 | 2530662 | 2530668 | 7mer-m8 | 2530646 | 2530669 | 140 | -12.5 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000162066.15 | ENST00000648227.1 | AMDHD2-219 | hsa-miR-641 | chr16 | 2530662 | 2530668 | 7mer-m8 | 2530646 | 2530669 | 140 | -12.5 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000162066.15 | ENST00000302956.8 | AMDHD2-202 | hsa-miR-5585-3p | chr16 | 2531177 | 2531183 | 7mer-m8 | 2531163 | 2531184 | 145 | -19.29 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000162066.15 | ENST00000648227.1 | AMDHD2-219 | hsa-miR-5585-3p | chr16 | 2531177 | 2531183 | 7mer-m8 | 2531163 | 2531184 | 145 | -19.29 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_527135 | chr16_24203190_+ | ENSG00000162066.15 | ENST00000302956.8 | AMDHD2-202 | hsa-miR-1273h-3p | chr16 | 2529874 | 2529880 | 7mer-m8 | 2529858 | 2529881 | 153 | -20.56 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000162066.15 | ENST00000648227.1 | AMDHD2-219 | hsa-miR-1273h-3p | chr16 | 2529874 | 2529880 | 7mer-m8 | 2529858 | 2529881 | 153 | -20.56 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for AMDHD2 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for AMDHD2 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_530177 | chr16_2521848_+ | 0.00161117018253277 | 0.178409639369292 | 0.0166157608511061 | 0.135949690651257 | 1.33154502372553e-09 | 0.335697409071076 |
| CER | ADediting_530184 | chr16_2522213_+ | 0.105277693034648 | 0.132779668443306 | 0.00549861391001751 | 0.225638313328552 | 0.000159360015855653 | 0.303542522933513 |
| DLPFC | ADediting_530209 | chr16_2522921_+ | 1.61726216637468e-08 | 0.313941933009846 | 2.34981871050415e-06 | 0.26440189112107 | 2.71377964444621e-08 | 0.309206528515847 |
| DLPFC | ADediting_530214 | chr16_2522973_+ | 0.000639305758654766 | 0.19287811099464 | 0.285979368953243 | 0.0607900957447094 | 4.60141793668996e-20 | 0.489268955604996 |
| DLPFC | ADediting_530217 | chr16_2523010_+ | 2.50965077996552e-05 | 0.236877165841192 | 0.0902184876811896 | 0.0963919349893039 | 7.10516216287571e-22 | 0.509428860397915 |
| DLPFC | ADediting_530221 | chr16_2523046_+ | 4.03127759710329e-05 | 0.230959606561243 | 0.00116278038822633 | 0.183636521706579 | 6.46974120114566e-11 | 0.359962477883896 |
| DLPFC | ADediting_530223 | chr16_2523078_+ | 0.00224088830348419 | 0.172974504141172 | 0.324272284994584 | 0.0561676269667681 | 9.61427947919416e-16 | 0.435010317403713 |
| DLPFC | ADediting_530225 | chr16_2523094_+ | 2.17441860445091e-05 | 0.238637820984266 | 0.00244951210222169 | 0.171481028979012 | 1.22900281354835e-10 | 0.354984705766046 |
| DLPFC | ADediting_530227 | chr16_2523110_+ | 1.30842101299491e-08 | 0.315856941086425 | 6.16665846512212e-05 | 0.225517864181519 | 1.00642490676611e-08 | 0.318209747092235 |
| DLPFC | ADediting_530233 | chr16_2525157_+ | 1.3716526837351e-08 | 0.315431620112356 | 0.000234377856923695 | 0.207498793555157 | 2.07353860928196e-06 | 0.26577188776537 |
| CER | ADediting_530234 | chr16_2525174_+ | 0.00947469948878949 | 0.211206211976688 | 5.42369563595372e-06 | 0.361693229966925 | 0.000682737384652408 | 0.274273265340482 |
| CER | ADediting_530237 | chr16_2525267_+ | 0.0629957725599554 | 0.152192392835219 | 7.13415270244343e-05 | 0.31847255498218 | 0.805187667050494 | 0.0203057756484518 |
| DLPFC | ADediting_530280 | chr16_2526766_+ | 0.000127206174769715 | 0.215931322687633 | 0.00512341867887308 | 0.158615268544936 | 3.30027262765646e-10 | 0.347147803369511 |
| DLPFC | ADediting_530291 | chr16_2526842_+ | 0.0212161987150822 | 0.130830487140531 | 0.190528606692607 | 0.0745448291457698 | 5.66852397249391e-09 | 0.323286986591665 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 9.45348121716401e-25 | 0.538916644818316 | 2.46429936966718e-24 | 0.534824633749422 | 1.37398793935181e-25 | 0.546988130142903 |
| AC | 4.42754589330616e-12 | 0.419569120209934 | 6.88153871240654e-12 | 0.416119465284121 | 5.30732598389262e-17 | 0.496997680717821 |
| PCC | 2.48754706647276e-37 | 0.760779723753937 | 5.37986261004934e-37 | 0.758516095026586 | 1.02871874164456e-07 | 0.373482213260972 |
| TCX | 1.71199141105973e-08 | 0.440347916793801 | 8.27569287465409e-06 | 0.35502883738939 | 0.0138978007672663 | 0.20048311071247 |
| FP | 3.14108310987386e-11 | 0.471303253728792 | 2.69816026878014e-10 | 0.450849167101767 | 2.5328830594525e-09 | 0.428004002818014 |
| IFG | 0.000491157781789056 | 0.645627008374611 | 6.5090455073713e-05 | 0.712205044019245 | 0.0470234550972586 | 0.400901519984038 |
| STG | 1.65324679429492e-07 | 0.534305488042221 | 0.000103080806294662 | 0.410971899501038 | 0.00024126057954962 | 0.390408086237227 |
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Relation with AD stages for AMDHD2 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_530189 | chr16_2522357_+ | 0.00139862387588913 | 0.303672355067045 |
| CER | ADediting_530227 | chr16_2523110_+ | 0.00111528373106356 | 0.309526616651326 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for AMDHD2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AMDHD2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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