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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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Gene summary for TPRKB |
 Gene summary |
| Gene information | Gene symbol | TPRKB | Gene ID | 51002 |
| Gene name | TP53RK binding protein | |
| Synonyms | CGI-121|CGI121|GAMOS5 | |
| Cytomap | 2p13.1 | |
| Type of gene | protein-coding | |
| Description | EKC/KEOPS complex subunit TPRKBPRPK (p53-related protein kinase)-binding protein | |
| Modification date | 20200313 | |
| UniProtAcc | Q9Y3C4, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TPRKB | GO:0002949 | tRNA threonylcarbamoyladenosine modification | 28805828 |
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RNA A-to-I events for TPRKB |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_899644(73729255, -), ADediting_899645(73732455, -), ADediting_899646(73732461, -), ADediting_899647(73732467, -), ADediting_899648(73732468, -), ADediting_899649(73732469, -), ADediting_899650(73732482, -), ADediting_899651(73732495, -), ADediting_899652(73732541, -), ADediting_899653(73732543, -), ADediting_899654(73732546, -), ADediting_899655(73732561, -), ADediting_899656(73732574, -), ADediting_899657(73732585, -), ADediting_899658(73732587, -), ADediting_899659(73732609, -), ADediting_899660(73732622, -), ADediting_899661(73732623, -), ADediting_899662(73732626, -), ADediting_899663(73732627, -), ADediting_899664(73732652, -), ADediting_899665(73732670, -), ADediting_899666(73733337, -), ADediting_899667(73733397, -), ADediting_899668(73733458, -), ADediting_899669(73733903, -), ADediting_899670(73733981, -), ADediting_899671(73734092, -), ADediting_899672(73734236, -), ADediting_899673(73734358, -), ADediting_1564512(73733387, -), ADediting_1564513(73733432, -), |
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RNA editing positional annotations for TPRKB using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_899657 | chr2_73732585_- | nonsynonymous SNV | ENST00000409716.6 | c.A257G | p.Q86R | 0.112 | . | -0.2 |
| ADediting_899657 | chr2_73732585_- | nonsynonymous SNV | ENST00000318190.7 | c.A257G | p.Q86R | 0.112 | . | -0.2 |
| ADediting_899658 | chr2_73732587_- | synonymous SNV | ENST00000409716.6 | c.A255G | p.L85L | . | . | . |
| ADediting_899658 | chr2_73732587_- | synonymous SNV | ENST00000318190.7 | c.A255G | p.L85L | . | . | . |
| ADediting_899659 | chr2_73732609_- | nonsynonymous SNV | ENST00000409716.6 | c.A233G | p.Q78R | 0.0 | . | -0.03 |
| ADediting_899659 | chr2_73732609_- | nonsynonymous SNV | ENST00000318190.7 | c.A233G | p.Q78R | 0.0 | . | -0.03 |
| ADediting_899660 | chr2_73732622_- | nonsynonymous SNV | ENST00000409716.6 | c.A220G | p.I74V | 0.0 | . | -0.02 |
| ADediting_899660 | chr2_73732622_- | nonsynonymous SNV | ENST00000318190.7 | c.A220G | p.I74V | 0.0 | . | -0.02 |
| ADediting_899661 | chr2_73732623_- | synonymous SNV | ENST00000409716.6 | c.A219G | p.A73A | . | . | . |
| ADediting_899661 | chr2_73732623_- | synonymous SNV | ENST00000318190.7 | c.A219G | p.A73A | . | . | . |
| ADediting_899662 | chr2_73732626_- | synonymous SNV | ENST00000409716.6 | c.A216G | p.Q72Q | . | . | . |
| ADediting_899662 | chr2_73732626_- | synonymous SNV | ENST00000318190.7 | c.A216G | p.Q72Q | . | . | . |
| ADediting_899663 | chr2_73732627_- | nonsynonymous SNV | ENST00000409716.6 | c.A215G | p.Q72R | 0.0 | . | -0.03 |
| ADediting_899663 | chr2_73732627_- | nonsynonymous SNV | ENST00000318190.7 | c.A215G | p.Q72R | 0.0 | . | -0.03 |
| ADediting_899664 | chr2_73732652_- | nonsynonymous SNV | ENST00000409716.6 | c.A190G | p.T64A | 0.0 | . | -0.08 |
| ADediting_899664 | chr2_73732652_- | nonsynonymous SNV | ENST00000318190.7 | c.A190G | p.T64A | 0.0 | . | -0.08 |
| ADediting_899665 | chr2_73732670_- | nonsynonymous SNV | ENST00000409716.6 | c.A172G | p.M58V | 0.022 | 0.043 | 0.03 |
| ADediting_899665 | chr2_73732670_- | nonsynonymous SNV | ENST00000318190.7 | c.A172G | p.M58V | 0.022 | 0.043 | 0.03 |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_899644 | chr2_73729255_- | downstream |
| ADediting_899645 | chr2_73732455_- | intronic |
| ADediting_899646 | chr2_73732461_- | intronic |
| ADediting_899647 | chr2_73732467_- | intronic |
| ADediting_899648 | chr2_73732468_- | intronic |
| ADediting_899649 | chr2_73732469_- | intronic |
| ADediting_899650 | chr2_73732482_- | intronic |
| ADediting_899651 | chr2_73732495_- | intronic |
| ADediting_899652 | chr2_73732541_- | intronic |
| ADediting_899653 | chr2_73732543_- | intronic |
| ADediting_899654 | chr2_73732546_- | intronic |
| ADediting_899655 | chr2_73732561_- | intronic |
| ADediting_899656 | chr2_73732574_- | intronic |
| ADediting_899657 | chr2_73732585_- | exonic |
| ADediting_899658 | chr2_73732587_- | exonic |
| ADediting_899659 | chr2_73732609_- | exonic |
| ADediting_899660 | chr2_73732622_- | exonic |
| ADediting_899661 | chr2_73732623_- | exonic |
| ADediting_899662 | chr2_73732626_- | exonic |
| ADediting_899663 | chr2_73732627_- | exonic |
| ADediting_899664 | chr2_73732652_- | exonic |
| ADediting_899665 | chr2_73732670_- | exonic |
| ADediting_899666 | chr2_73733337_- | intronic |
| ADediting_899667 | chr2_73733397_- | intronic |
| ADediting_899668 | chr2_73733458_- | intronic |
| ADediting_899669 | chr2_73733903_- | intronic |
| ADediting_899670 | chr2_73733981_- | intronic |
| ADediting_899671 | chr2_73734092_- | intronic |
| ADediting_899672 | chr2_73734236_- | intronic |
| ADediting_899673 | chr2_73734358_- | intronic |
| ADediting_1564512 | chr2_73733387_- | intronic |
| ADediting_1564513 | chr2_73733432_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_899644 | chr2_73729255_- | SINE | Alu | Name=FLAM_C |
| ADediting_899645 | chr2_73732455_- | SINE | Alu | Name=AluSq2 |
| ADediting_899646 | chr2_73732461_- | SINE | Alu | Name=AluSq2 |
| ADediting_899647 | chr2_73732467_- | SINE | Alu | Name=AluSq2 |
| ADediting_899648 | chr2_73732468_- | SINE | Alu | Name=AluSq2 |
| ADediting_899649 | chr2_73732469_- | SINE | Alu | Name=AluSq2 |
| ADediting_899650 | chr2_73732482_- | SINE | Alu | Name=AluSq2 |
| ADediting_899651 | chr2_73732495_- | SINE | Alu | Name=AluSq2 |
| ADediting_899652 | chr2_73732541_- | SINE | Alu | Name=AluSq2 |
| ADediting_899653 | chr2_73732543_- | SINE | Alu | Name=AluSq2 |
| ADediting_899654 | chr2_73732546_- | SINE | Alu | Name=AluSq2 |
| ADediting_899655 | chr2_73732561_- | SINE | Alu | Name=AluSq2 |
| ADediting_899656 | chr2_73732574_- | SINE | Alu | Name=AluSq2 |
| ADediting_899657 | chr2_73732585_- | SINE | Alu | Name=AluSq2 |
| ADediting_899658 | chr2_73732587_- | SINE | Alu | Name=AluSq2 |
| ADediting_899659 | chr2_73732609_- | SINE | Alu | Name=AluSq2 |
| ADediting_899660 | chr2_73732622_- | SINE | Alu | Name=AluSq2 |
| ADediting_899661 | chr2_73732623_- | SINE | Alu | Name=AluSq2 |
| ADediting_899662 | chr2_73732626_- | SINE | Alu | Name=AluSq2 |
| ADediting_899663 | chr2_73732627_- | SINE | Alu | Name=AluSq2 |
| ADediting_899664 | chr2_73732652_- | SINE | Alu | Name=AluSq2 |
| ADediting_899665 | chr2_73732670_- | SINE | Alu | Name=AluSq2 |
| ADediting_899666 | chr2_73733337_- | SINE | Alu | Name=AluSz6 |
| ADediting_899667 | chr2_73733397_- | SINE | Alu | Name=AluSz6 |
| ADediting_899668 | chr2_73733458_- | SINE | Alu | Name=AluSz6 |
| ADediting_899669 | chr2_73733903_- | SINE | Alu | Name=AluSx1 |
| ADediting_899670 | chr2_73733981_- | SINE | Alu | Name=AluSx1 |
| ADediting_899671 | chr2_73734092_- | SINE | Alu | Name=AluSx1 |
| ADediting_899672 | chr2_73734236_- | SINE | Alu | Name=AluSq2 |
| ADediting_899673 | chr2_73734358_- | SINE | Alu | Name=AluSq2 |
| ADediting_1564512 | chr2_73733387_- | SINE | Alu | Name=AluSz6 |
| ADediting_1564513 | chr2_73733432_- | SINE | Alu | Name=AluSz6 |
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RNA A-to-I editing events in the alternative splicing sites for TPRKB |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| ES | ADediting_899657 | chr2_73732585_- | 73732578:73732586 | 5ss | 2e | CAGGTGCGT | 9.73 | CGGGTGCGT | 7.91 |
| ES | ADediting_899657 | chr2_73732585_- | 73732578:73732586 | 5ss | 2e | CAGGTGCGT | 9.73 | CGGGTGCGT | 7.91 |
| ES | ADediting_899657 | chr2_73732585_- | 73732578:73732586 | 5ss | 2e | CAGGTGCGT | 9.73 | CGGGTGCGT | 7.91 |
| ES | ADediting_899657 | chr2_73732585_- | 73732578:73732586 | 5ss | 2e | CAGGTGCGT | 9.73 | CGGGTGCGT | 7.91 |
| ME2 | ADediting_899657 | chr2_73732585_- | 73732578:73732586 | 5ss | 2e | CAGGTGCGT | 9.73 | CGGGTGCGT | 7.91 |
| ME2 | ADediting_899657 | chr2_73732585_- | 73732578:73732586 | 5ss | 2e | CAGGTGCGT | 9.73 | CGGGTGCGT | 7.91 |
| ME2 | ADediting_899657 | chr2_73732585_- | 73732578:73732586 | 5ss | 2e | CAGGTGCGT | 9.73 | CGGGTGCGT | 7.91 |
| ME2 | ADediting_899657 | chr2_73732585_- | 73732578:73732586 | 5ss | 2e | CAGGTGCGT | 9.73 | CGGGTGCGT | 7.91 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TPRKB |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for TPRKB |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for TPRKB |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_899644 | chr2_73729255_- | ENSG00000144034.15 | ENST00000463231.5 | TPRKB-205 | hsa-miR-3622a-3p | chr2 | 73729251 | 73729258 | 8mer-1a | 73729251 | 73729271 | 143 | -16 |
| ADediting_899644 | chr2_73729255_- | ENSG00000144034.15 | ENST00000463231.5 | TPRKB-205 | hsa-miR-3622b-3p | chr2 | 73729251 | 73729258 | 8mer-1a | 73729251 | 73729270 | 153 | -20.92 |
| ADediting_899644 | chr2_73729255_- | ENSG00000144034.15 | ENST00000484969.5 | TPRKB-207 | hsa-miR-3622a-3p | chr2 | 73729251 | 73729258 | 8mer-1a | 73729251 | 73729271 | 143 | -16 |
| ADediting_899644 | chr2_73729255_- | ENSG00000144034.15 | ENST00000484969.5 | TPRKB-207 | hsa-miR-3622b-3p | chr2 | 73729251 | 73729258 | 8mer-1a | 73729251 | 73729270 | 153 | -20.92 |
| ADediting_899644 | chr2_73729255_- | ENSG00000144034.15 | ENST00000489476.5 | TPRKB-209 | hsa-miR-3622a-3p | chr2 | 73729251 | 73729258 | 8mer-1a | 73729251 | 73729271 | 143 | -16 |
| ADediting_899644 | chr2_73729255_- | ENSG00000144034.15 | ENST00000489476.5 | TPRKB-209 | hsa-miR-3622b-3p | chr2 | 73729251 | 73729258 | 8mer-1a | 73729251 | 73729270 | 153 | -20.92 |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_899644 | chr2_73729255_- | ENSG00000144034.15 | ENST00000463231.5 | TPRKB-205 | hsa-miR-8081 | chr2 | 73729255 | 73729261 | 7mer-m8 | 73729254 | 73729275 | 154 | -13.1 |
| ADediting_899644 | chr2_73729255_- | ENSG00000144034.15 | ENST00000484969.5 | TPRKB-207 | hsa-miR-8081 | chr2 | 73729255 | 73729261 | 7mer-m8 | 73729254 | 73729275 | 154 | -13.1 |
| ADediting_899644 | chr2_73729255_- | ENSG00000144034.15 | ENST00000489476.5 | TPRKB-209 | hsa-miR-8081 | chr2 | 73729255 | 73729261 | 7mer-m8 | 73729254 | 73729275 | 154 | -13.1 |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for TPRKB |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000489476.5 | lncRNA |  |  |
| ENST00000463231.5 | lncRNA |  |  |
| ENST00000484969.5 | lncRNA |  |  |
| ENST00000409716.6 | protein_coding |  |  |
| ENST00000318190.7 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_899657 | ENST00000409716.6 | chr2_73732585_- | 375 | -195.60 | -196.40 | -203.70 |
| ADediting_899658 | ENST00000409716.6 | chr2_73732587_- | 373 | -195.00 | -196.40 | -203.70 |
| ADediting_899659 | ENST00000409716.6 | chr2_73732609_- | 351 | -196.70 | -196.40 | -203.70 |
| ADediting_899660 | ENST00000409716.6 | chr2_73732622_- | 338 | -197.20 | -196.40 | -203.70 |
| ADediting_899661 | ENST00000409716.6 | chr2_73732623_- | 337 | -197.40 | -196.40 | -203.70 |
| ADediting_899662 | ENST00000409716.6 | chr2_73732626_- | 334 | -197.90 | -196.40 | -203.70 |
| ADediting_899663 | ENST00000409716.6 | chr2_73732627_- | 333 | -197.90 | -196.40 | -203.70 |
| ADediting_899664 | ENST00000409716.6 | chr2_73732652_- | 308 | -198.50 | -196.40 | -203.70 |
| ADediting_899665 | ENST00000409716.6 | chr2_73732670_- | 290 | -197.00 | -196.40 | -203.70 |
| ADediting_899657 | ENST00000318190.7 | chr2_73732585_- | 378 | -195.70 | -196.50 | -204.40 |
| ADediting_899658 | ENST00000318190.7 | chr2_73732587_- | 376 | -196.10 | -196.50 | -204.40 |
| ADediting_899659 | ENST00000318190.7 | chr2_73732609_- | 354 | -197.80 | -196.50 | -204.40 |
| ADediting_899660 | ENST00000318190.7 | chr2_73732622_- | 341 | -197.90 | -196.50 | -204.40 |
| ADediting_899661 | ENST00000318190.7 | chr2_73732623_- | 340 | -198.50 | -196.50 | -204.40 |
| ADediting_899662 | ENST00000318190.7 | chr2_73732626_- | 337 | -198.80 | -196.50 | -204.40 |
| ADediting_899663 | ENST00000318190.7 | chr2_73732627_- | 336 | -199.00 | -196.50 | -204.40 |
| ADediting_899664 | ENST00000318190.7 | chr2_73732652_- | 311 | -199.60 | -196.50 | -204.40 |
| ADediting_899665 | ENST00000318190.7 | chr2_73732670_- | 293 | -198.10 | -196.50 | -204.40 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_899644 | ENST00000489476.5 | chr2_73729255_- | 385 | -124.90 | -120.40 | -124.90 |
| ADediting_899644 | ENST00000463231.5 | chr2_73729255_- | 489 | -147.30 | -142.80 | -147.30 |
| ADediting_899644 | ENST00000484969.5 | chr2_73729255_- | 571 | -137.80 | -134.20 | -137.80 |
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Relation with ADAR for TPRKB |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_899644 | chr2_73729255_- | 0.0145366844195194 | 0.199191553417238 | 4.77133416982618e-05 | 0.3256596566714 | 0.0737108739794821 | 0.146459309981365 |
| CER | ADediting_899646 | chr2_73732461_- | 8.70406007720288e-05 | 0.314850722015803 | 5.24466647936094e-06 | 0.362216270876943 | 0.14495075686326 | 0.119585435324716 |
| DLPFC | ADediting_899653 | chr2_73732543_- | 0.0167600044309821 | 0.135771379431686 | 0.219827716846043 | 0.0698852293074074 | 3.34571713565043e-10 | 0.347037770640285 |
| DLPFC | ADediting_899657 | chr2_73732585_- | 0.36196039333253 | 0.0519523430698015 | 0.798452739368425 | 0.0145609626410076 | 4.33628219629476e-08 | 0.304845496950328 |
| DLPFC | ADediting_899658 | chr2_73732587_- | 0.0619594208986308 | 0.106144084499435 | 0.151190518052958 | 0.0817154967948194 | 3.92353902025337e-08 | 0.305782209482737 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 4.86020082941563e-32 | 0.602697157010136 | 3.58355785233763e-36 | 0.633408053609624 | 0.34869947964518 | 0.0534022914963032 |
| AC | 3.6927223748306e-64 | 0.827678297027449 | 2.73163838491697e-42 | 0.726478605107618 | 5.20006308233732e-17 | 0.497120921029619 |
| PCC | 2.29722363043413e-16 | 0.548029841703807 | 2.29595490406018e-17 | 0.56302210291094 | 0.012596586365005 | 0.180232323558424 |
| TCX | 1.96379160567527e-14 | 0.572435728255981 | 2.08176313705979e-07 | 0.408674823813845 | 6.80690013597142e-06 | 0.358129096115745 |
| FP | 1.04959374094542e-16 | 0.569710810748247 | 2.77817563357842e-25 | 0.677728085188127 | 0.174747225046669 | 0.102172896069009 |
| IFG | 0.000413112184387978 | 0.652017933100938 | 0.00420728300913729 | 0.552215535966069 | 0.183030627793583 | 0.275209446492242 |
| PG | 5.24754738538172e-45 | 0.812581732979507 | 2.60148776835286e-22 | 0.634089826225734 | 0.791395832297616 | 0.01952373646548 |
| STG | 4.64693967656237e-09 | 0.586267728848344 | 4.35452789602472e-11 | 0.642748838029706 | 0.813202979589091 | -0.0261697185099181 |
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Relation with AD stages for TPRKB |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for TPRKB |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TPRKB |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TPRKB | C0025958 | Microcephaly | 1 | GENOMICS_ENGLAND |
| TPRKB | C0795949 | Galloway Mowat syndrome | 1 | CTD_human;ORPHANET |
| TPRKB | C4540274 | GALLOWAY-MOWAT SYNDROME 5 | 1 | UNIPROT |
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