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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for ANO7 |
 Gene summary |
| Gene information | Gene symbol | ANO7 | Gene ID | 50636 |
| Gene name | anoctamin 7 | |
| Synonyms | D-TMPP|DTMPP|IPCA-5|IPCA5|NGEP|PCANAP5|PCANAP5L|TMEM16G | |
| Cytomap | 2q37.3 | |
| Type of gene | protein-coding | |
| Description | anoctamin-7Dresden-transmembrane protein of the prostateprostate cancer associated protein 5transmembrane protein 16G | |
| Modification date | 20200313 | |
| UniProtAcc | Q6IWH7, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ANO7 | GO:0006821 | chloride transport | 22946059 |
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RNA A-to-I events for ANO7 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_857001(241219616, +), ADediting_857002(241219642, +), ADediting_857003(241219667, +), ADediting_857004(241219668, +), ADediting_857005(241219680, +), ADediting_857006(241219701, +), ADediting_857007(241219793, +), ADediting_857008(241219799, +), ADediting_857009(241219835, +), ADediting_857010(241219855, +), ADediting_857011(241220428, +), ADediting_857012(241220439, +), ADediting_857013(241220441, +), ADediting_857014(241220442, +), ADediting_857015(241220450, +), ADediting_857016(241220468, +), ADediting_857017(241220487, +), ADediting_857018(241220496, +), ADediting_857019(241220574, +), ADediting_857020(241220624, +), ADediting_857021(241220635, +), ADediting_857022(241220640, +), ADediting_857023(241220644, +), ADediting_857024(241220653, +), ADediting_857025(241220679, +), ADediting_857026(241220689, +), ADediting_857027(241220696, +), ADediting_857028(241220702, +), ADediting_857029(241220732, +), ADediting_857030(241220788, +), ADediting_857031(241220850, +), ADediting_857032(241220851, +), ADediting_857033(241220877, +), ADediting_857034(241220916, +), ADediting_857035(241221128, +), ADediting_857036(241221241, +), ADediting_857037(241221250, +), ADediting_857038(241221337, +), ADediting_857039(241221338, +), ADediting_857040(241221402, +), ADediting_857041(241221418, +), ADediting_857042(241221432, +), ADediting_857043(241221443, +), ADediting_857044(241221495, +), ADediting_857045(241221509, +), ADediting_857046(241221561, +), ADediting_857047(241221579, +), ADediting_857048(241221599, +), ADediting_857049(241221739, +), ADediting_857050(241221752, +), ADediting_857051(241221851, +), ADediting_857052(241221894, +), ADediting_857053(241221932, +), ADediting_857054(241221988, +), ADediting_857055(241222047, +), ADediting_857056(241222071, +), ADediting_857057(241222073, +), ADediting_857058(241222074, +), ADediting_857059(241222075, +), ADediting_857060(241222080, +), ADediting_857061(241222113, +), ADediting_857062(241222127, +), ADediting_857063(241225249, +), ADediting_857064(241225264, +), ADediting_857065(241225270, +), ADediting_857066(241225271, +), ADediting_857067(241225297, +), ADediting_857068(241225308, +), ADediting_857069(241225338, +), ADediting_857070(241225348, +), ADediting_1562800(241220568, +), ADediting_1562801(241225262, +), |
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RNA editing positional annotations for ANO7 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_857001 | chr2_241219616_+ | intronic |
| ADediting_857002 | chr2_241219642_+ | intronic |
| ADediting_857003 | chr2_241219667_+ | intronic |
| ADediting_857004 | chr2_241219668_+ | intronic |
| ADediting_857005 | chr2_241219680_+ | intronic |
| ADediting_857006 | chr2_241219701_+ | intronic |
| ADediting_857007 | chr2_241219793_+ | intronic |
| ADediting_857008 | chr2_241219799_+ | intronic |
| ADediting_857009 | chr2_241219835_+ | intronic |
| ADediting_857010 | chr2_241219855_+ | intronic |
| ADediting_857011 | chr2_241220428_+ | intronic |
| ADediting_857012 | chr2_241220439_+ | intronic |
| ADediting_857013 | chr2_241220441_+ | intronic |
| ADediting_857014 | chr2_241220442_+ | intronic |
| ADediting_857015 | chr2_241220450_+ | intronic |
| ADediting_857016 | chr2_241220468_+ | intronic |
| ADediting_857017 | chr2_241220487_+ | intronic |
| ADediting_857018 | chr2_241220496_+ | intronic |
| ADediting_857019 | chr2_241220574_+ | intronic |
| ADediting_857020 | chr2_241220624_+ | intronic |
| ADediting_857021 | chr2_241220635_+ | intronic |
| ADediting_857022 | chr2_241220640_+ | intronic |
| ADediting_857023 | chr2_241220644_+ | intronic |
| ADediting_857024 | chr2_241220653_+ | intronic |
| ADediting_857025 | chr2_241220679_+ | intronic |
| ADediting_857026 | chr2_241220689_+ | intronic |
| ADediting_857027 | chr2_241220696_+ | intronic |
| ADediting_857028 | chr2_241220702_+ | intronic |
| ADediting_857029 | chr2_241220732_+ | intronic |
| ADediting_857030 | chr2_241220788_+ | intronic |
| ADediting_857031 | chr2_241220850_+ | intronic |
| ADediting_857032 | chr2_241220851_+ | intronic |
| ADediting_857033 | chr2_241220877_+ | intronic |
| ADediting_857034 | chr2_241220916_+ | intronic |
| ADediting_857035 | chr2_241221128_+ | intronic |
| ADediting_857036 | chr2_241221241_+ | intronic |
| ADediting_857037 | chr2_241221250_+ | intronic |
| ADediting_857038 | chr2_241221337_+ | intronic |
| ADediting_857039 | chr2_241221338_+ | intronic |
| ADediting_857040 | chr2_241221402_+ | intronic |
| ADediting_857041 | chr2_241221418_+ | intronic |
| ADediting_857042 | chr2_241221432_+ | intronic |
| ADediting_857043 | chr2_241221443_+ | intronic |
| ADediting_857044 | chr2_241221495_+ | intronic |
| ADediting_857045 | chr2_241221509_+ | intronic |
| ADediting_857046 | chr2_241221561_+ | intronic |
| ADediting_857047 | chr2_241221579_+ | intronic |
| ADediting_857048 | chr2_241221599_+ | intronic |
| ADediting_857049 | chr2_241221739_+ | intronic |
| ADediting_857050 | chr2_241221752_+ | intronic |
| ADediting_857051 | chr2_241221851_+ | intronic |
| ADediting_857052 | chr2_241221894_+ | intronic |
| ADediting_857053 | chr2_241221932_+ | intronic |
| ADediting_857054 | chr2_241221988_+ | intronic |
| ADediting_857055 | chr2_241222047_+ | intronic |
| ADediting_857056 | chr2_241222071_+ | intronic |
| ADediting_857057 | chr2_241222073_+ | intronic |
| ADediting_857058 | chr2_241222074_+ | intronic |
| ADediting_857059 | chr2_241222075_+ | intronic |
| ADediting_857060 | chr2_241222080_+ | intronic |
| ADediting_857061 | chr2_241222113_+ | intronic |
| ADediting_857062 | chr2_241222127_+ | intronic |
| ADediting_857063 | chr2_241225249_+ | UTR3 |
| ADediting_857064 | chr2_241225264_+ | UTR3 |
| ADediting_857065 | chr2_241225270_+ | UTR3 |
| ADediting_857066 | chr2_241225271_+ | UTR3 |
| ADediting_857067 | chr2_241225297_+ | UTR3 |
| ADediting_857068 | chr2_241225308_+ | UTR3 |
| ADediting_857069 | chr2_241225338_+ | UTR3 |
| ADediting_857070 | chr2_241225348_+ | UTR3 |
| ADediting_1562800 | chr2_241220568_+ | intronic |
| ADediting_1562801 | chr2_241225262_+ | UTR3 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_857001 | chr2_241219616_+ | SINE | Alu | Name=AluJr |
| ADediting_857002 | chr2_241219642_+ | SINE | Alu | Name=AluJr |
| ADediting_857003 | chr2_241219667_+ | SINE | Alu | Name=AluJr |
| ADediting_857004 | chr2_241219668_+ | SINE | Alu | Name=AluJr |
| ADediting_857005 | chr2_241219680_+ | SINE | Alu | Name=AluJr |
| ADediting_857006 | chr2_241219701_+ | SINE | Alu | Name=AluJr |
| ADediting_857007 | chr2_241219793_+ | SINE | Alu | Name=AluJr |
| ADediting_857008 | chr2_241219799_+ | SINE | Alu | Name=AluJr |
| ADediting_857009 | chr2_241219835_+ | SINE | Alu | Name=AluJr |
| ADediting_857010 | chr2_241219855_+ | SINE | Alu | Name=AluJr |
| ADediting_857011 | chr2_241220428_+ | SINE | Alu | Name=AluSz |
| ADediting_857012 | chr2_241220439_+ | SINE | Alu | Name=AluSz |
| ADediting_857013 | chr2_241220441_+ | SINE | Alu | Name=AluSz |
| ADediting_857014 | chr2_241220442_+ | SINE | Alu | Name=AluSz |
| ADediting_857015 | chr2_241220450_+ | SINE | Alu | Name=AluSz |
| ADediting_857016 | chr2_241220468_+ | SINE | Alu | Name=AluSz |
| ADediting_857017 | chr2_241220487_+ | SINE | Alu | Name=AluSz |
| ADediting_857018 | chr2_241220496_+ | SINE | Alu | Name=AluSz |
| ADediting_857019 | chr2_241220574_+ | SINE | Alu | Name=AluY |
| ADediting_857020 | chr2_241220624_+ | SINE | Alu | Name=AluY |
| ADediting_857021 | chr2_241220635_+ | SINE | Alu | Name=AluY |
| ADediting_857022 | chr2_241220640_+ | SINE | Alu | Name=AluY |
| ADediting_857023 | chr2_241220644_+ | SINE | Alu | Name=AluY |
| ADediting_857024 | chr2_241220653_+ | SINE | Alu | Name=AluY |
| ADediting_857025 | chr2_241220679_+ | SINE | Alu | Name=AluY |
| ADediting_857026 | chr2_241220689_+ | SINE | Alu | Name=AluY |
| ADediting_857027 | chr2_241220696_+ | SINE | Alu | Name=AluY |
| ADediting_857028 | chr2_241220702_+ | SINE | Alu | Name=AluY |
| ADediting_857029 | chr2_241220732_+ | SINE | Alu | Name=AluY |
| ADediting_857030 | chr2_241220788_+ | SINE | Alu | Name=AluY |
| ADediting_857031 | chr2_241220850_+ | SINE | Alu | Name=AluSz |
| ADediting_857032 | chr2_241220851_+ | SINE | Alu | Name=AluSz |
| ADediting_857033 | chr2_241220877_+ | SINE | Alu | Name=AluSz |
| ADediting_857034 | chr2_241220916_+ | SINE | Alu | Name=AluSz |
| ADediting_857035 | chr2_241221128_+ | SINE | Alu | Name=AluSx1 |
| ADediting_857036 | chr2_241221241_+ | SINE | Alu | Name=AluSx1 |
| ADediting_857037 | chr2_241221250_+ | SINE | Alu | Name=AluSx1 |
| ADediting_857038 | chr2_241221337_+ | SINE | Alu | Name=AluSx1 |
| ADediting_857039 | chr2_241221338_+ | SINE | Alu | Name=AluSx1 |
| ADediting_857040 | chr2_241221402_+ | SINE | Alu | Name=AluSx |
| ADediting_857041 | chr2_241221418_+ | SINE | Alu | Name=AluSx |
| ADediting_857042 | chr2_241221432_+ | SINE | Alu | Name=AluSx |
| ADediting_857043 | chr2_241221443_+ | SINE | Alu | Name=AluSx |
| ADediting_857044 | chr2_241221495_+ | SINE | Alu | Name=AluSx |
| ADediting_857045 | chr2_241221509_+ | SINE | Alu | Name=AluSx |
| ADediting_857046 | chr2_241221561_+ | SINE | Alu | Name=AluSx |
| ADediting_857047 | chr2_241221579_+ | SINE | Alu | Name=AluSx |
| ADediting_857048 | chr2_241221599_+ | SINE | Alu | Name=AluSx |
| ADediting_857049 | chr2_241221739_+ | SINE | Alu | Name=AluSq2 |
| ADediting_857050 | chr2_241221752_+ | SINE | Alu | Name=AluSq2 |
| ADediting_857051 | chr2_241221851_+ | SINE | Alu | Name=AluSq2 |
| ADediting_857052 | chr2_241221894_+ | SINE | Alu | Name=AluSq2 |
| ADediting_857053 | chr2_241221932_+ | SINE | Alu | Name=AluSq2 |
| ADediting_857054 | chr2_241221988_+ | SINE | Alu | Name=AluSc8 |
| ADediting_857055 | chr2_241222047_+ | SINE | Alu | Name=AluSc8 |
| ADediting_857056 | chr2_241222071_+ | SINE | Alu | Name=AluSc8 |
| ADediting_857057 | chr2_241222073_+ | SINE | Alu | Name=AluSc8 |
| ADediting_857058 | chr2_241222074_+ | SINE | Alu | Name=AluSc8 |
| ADediting_857059 | chr2_241222075_+ | SINE | Alu | Name=AluSc8 |
| ADediting_857060 | chr2_241222080_+ | SINE | Alu | Name=AluSc8 |
| ADediting_857061 | chr2_241222113_+ | SINE | Alu | Name=AluSc8 |
| ADediting_857062 | chr2_241222127_+ | SINE | Alu | Name=AluSc8 |
| ADediting_857063 | chr2_241225249_+ | SINE | Alu | Name=AluSg |
| ADediting_857064 | chr2_241225264_+ | SINE | Alu | Name=AluSg |
| ADediting_857065 | chr2_241225270_+ | SINE | Alu | Name=AluSg |
| ADediting_857066 | chr2_241225271_+ | SINE | Alu | Name=AluSg |
| ADediting_857067 | chr2_241225297_+ | SINE | Alu | Name=AluSg |
| ADediting_857068 | chr2_241225308_+ | SINE | Alu | Name=AluSg |
| ADediting_857069 | chr2_241225338_+ | SINE | Alu | Name=AluSg |
| ADediting_857070 | chr2_241225348_+ | SINE | Alu | Name=AluSg |
| ADediting_1562800 | chr2_241220568_+ | SINE | Alu | Name=AluY |
| ADediting_1562801 | chr2_241225262_+ | SINE | Alu | Name=AluSg |
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RNA A-to-I editing events in the alternative splicing sites for ANO7 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ANO7 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for ANO7 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for ANO7 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_857065 | chr2_241225270_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-513a-5p | chr2 | 241225264 | 241225270 | 7mer-m8 | 241225254 | 241225271 | 144 | -17.77 |
| ADediting_857065 | chr2_241225270_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-638 | chr2 | 241225269 | 241225275 | 7mer-1a | 241225251 | 241225275 | 151 | -32.73 |
| ADediting_857068 | chr2_241225308_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-6790-3p | chr2 | 241225306 | 241225313 | 8mer-1a | 241225292 | 241225313 | 148 | -21.12 |
| ADediting_857069 | chr2_241225338_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-4638-3p | chr2 | 241225331 | 241225337 | 7mer-m8 | 241225317 | 241225338 | 147 | -19.28 |
| ADediting_857070 | chr2_241225348_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-3158-3p | chr2 | 241225345 | 241225351 | 7mer-m8 | 241225332 | 241225352 | 150 | -22.54 |
| ADediting_857070 | chr2_241225348_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-412-3p | chr2 | 241225341 | 241225347 | 7mer-m8 | 241225325 | 241225348 | 151 | -16.52 |
| ADediting_857070 | chr2_241225348_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-6754-3p | chr2 | 241225341 | 241225347 | 7mer-m8 | 241225326 | 241225348 | 141 | -14.56 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1562801 | chr2_241225262_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-6807-5p | chr2 | 241225255 | 241225261 | 7mer-m8 | 241225241 | 241225262 | 140 | -16.43 |
| ADediting_857063 | chr2_241225249_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-574-3p | chr2 | 241225246 | 241225252 | 7mer-m8 | 241225233 | 241225253 | 154 | -23.44 |
| ADediting_857063 | chr2_241225249_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-6787-3p | chr2 | 241225243 | 241225249 | 7mer-m8 | 241225229 | 241225250 | 145 | -15.1 |
| ADediting_857064 | chr2_241225264_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-3934-5p | chr2 | 241225261 | 241225267 | 7mer-m8 | 241225246 | 241225268 | 149 | -21.25 |
| ADediting_857064 | chr2_241225264_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-552-3p | chr2 | 241225262 | 241225269 | 8mer-1a | 241225249 | 241225269 | 140 | -14.36 |
| ADediting_857065 | chr2_241225270_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-10399-5p | chr2 | 241225265 | 241225271 | 7mer-m8 | 241225251 | 241225272 | 148 | -10 |
| ADediting_857065 | chr2_241225270_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-6504-3p | chr2 | 241225265 | 241225271 | 7mer-m8 | 241225251 | 241225272 | 145 | -14.48 |
| ADediting_857066 | chr2_241225271_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-10399-5p | chr2 | 241225265 | 241225271 | 7mer-m8 | 241225251 | 241225272 | 148 | -10 |
| ADediting_857066 | chr2_241225271_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-5089-5p | chr2 | 241225269 | 241225275 | 7mer-m8 | 241225254 | 241225276 | 148 | -13.62 |
| ADediting_857066 | chr2_241225271_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-6504-3p | chr2 | 241225265 | 241225271 | 7mer-m8 | 241225251 | 241225272 | 145 | -14.48 |
| ADediting_857067 | chr2_241225297_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-1976 | chr2 | 241225294 | 241225300 | 7mer-m8 | 241225281 | 241225301 | 149 | -26.06 |
| ADediting_857067 | chr2_241225297_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-660-3p | chr2 | 241225295 | 241225302 | 8mer-1a | 241225283 | 241225302 | 144 | -16.11 |
| ADediting_857067 | chr2_241225297_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-6747-3p | chr2 | 241225292 | 241225299 | 8mer-1a | 241225278 | 241225299 | 150 | -24.16 |
| ADediting_857069 | chr2_241225338_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-4520-2-3p | chr2 | 241225331 | 241225337 | 7mer-m8 | 241225317 | 241225338 | 145 | -13.32 |
| ADediting_857069 | chr2_241225338_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-4716-5p | chr2 | 241225336 | 241225342 | 7mer-m8 | 241225322 | 241225343 | 140 | -13.06 |
| ADediting_857069 | chr2_241225338_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-4781-3p | chr2 | 241225334 | 241225340 | 7mer-m8 | 241225323 | 241225341 | 152 | -17.46 |
| ADediting_857070 | chr2_241225348_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-6823-5p | chr2 | 241225346 | 241225352 | 7mer-m8 | 241225333 | 241225353 | 143 | -17.07 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-381-3p | chr2 | 241224807 | 241224813 | 7mer-m8 | 241224794 | 241224814 | 149 | -15.45 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-641 | chr2 | 241225187 | 241225193 | 7mer-m8 | 241225170 | 241225194 | 155 | -19.97 |
| ADediting_496066 | chr15_66496985_- | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-4512 | chr2 | 241224451 | 241224457 | 7mer-m8 | 241224437 | 241224458 | 140 | -20.39 |
| ADediting_496066 | chr15_66496985_- | ENSG00000146205.13 | ENST00000402530.7 | ANO7-203 | hsa-miR-4512 | chr2 | 241195955 | 241195962 | 8mer-1a | 241195941 | 241195962 | 150 | -19.67 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000146205.13 | ENST00000402530.7 | ANO7-203 | hsa-miR-5585-3p | chr2 | 241196120 | 241196126 | 7mer-m8 | 241196106 | 241196127 | 149 | -15.12 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_496066 | chr15_66496985_- | ENSG00000146205.13 | ENST00000274979.12 | ANO7-201 | hsa-miR-4512 | chr2 | 241224369 | 241224375 | 7mer-m8 | 241224355 | 241224376 | 140 | -16.81 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for ANO7 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000274979.12 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_857063 | ENST00000274979.12 | chr2_241225249_+ | 4001 | -1693.30 | -1692.60 | -1702.40 |
| ADediting_1562801 | ENST00000274979.12 | chr2_241225262_+ | 4014 | -1692.60 | -1692.60 | -1702.40 |
| ADediting_857064 | ENST00000274979.12 | chr2_241225264_+ | 4016 | -1693.40 | -1692.60 | -1702.40 |
| ADediting_857065 | ENST00000274979.12 | chr2_241225270_+ | 4022 | -1697.10 | -1692.60 | -1702.40 |
| ADediting_857066 | ENST00000274979.12 | chr2_241225271_+ | 4023 | -1693.60 | -1692.60 | -1702.40 |
| ADediting_857067 | ENST00000274979.12 | chr2_241225297_+ | 4049 | -1693.50 | -1692.60 | -1702.40 |
| ADediting_857068 | ENST00000274979.12 | chr2_241225308_+ | 4060 | -1694.50 | -1692.60 | -1702.40 |
| ADediting_857069 | ENST00000274979.12 | chr2_241225338_+ | 4090 | -1695.90 | -1692.60 | -1702.40 |
| ADediting_857070 | ENST00000274979.12 | chr2_241225348_+ | 4100 | -1693.60 | -1692.60 | -1702.40 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for ANO7 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_857013 | chr2_241220441_+ | 0.996882001317824 | 0.000222850759563482 | 0.179212086874853 | -0.0764849699007192 | 6.54372971475662e-09 | 0.322025931295507 |
| DLPFC | ADediting_857037 | chr2_241221250_+ | 0.617351523883947 | 0.0284851094429301 | 0.137594489066961 | -0.0845219485308805 | 2.44463602172104e-09 | 0.330559889730592 |
| DLPFC | ADediting_857049 | chr2_241221739_+ | 0.328281862564676 | 0.0557047505595173 | 0.370980809121987 | -0.0509849170315182 | 2.84201808470947e-10 | 0.348347780886306 |
| DLPFC | ADediting_857052 | chr2_241221894_+ | 0.00402196543053541 | 0.162935579956984 | 0.885861048482985 | 0.00818564797694385 | 7.45062250280489e-10 | 0.340520371036941 |
| DLPFC | ADediting_857056 | chr2_241222071_+ | 0.0273757510136339 | 0.125311005374256 | 0.441139143000594 | -0.0439047185589234 | 1.42979971817791e-14 | 0.418447005313612 |
| DLPFC | ADediting_857058 | chr2_241222074_+ | 0.0317230874968188 | 0.122028243470971 | 0.595070491575956 | -0.0303028055778661 | 4.06462393378073e-21 | 0.501160275752488 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 3.0581373205947e-11 | 0.365668532836499 | 4.80350713097197e-15 | 0.42524947621637 | 0.00337921843055872 | 0.165981378662515 |
| AC | 3.06576522668734e-18 | 0.51374441767781 | 8.42896131417383e-12 | 0.414519527832727 | 4.79879348307519e-12 | 0.418942194999917 |
| PCC | 1.04836129326801e-05 | 0.312886438265594 | 0.000353866357543142 | 0.255846153811439 | 0.00649619969712969 | 0.196298669299012 |
| TCX | 0.00285099204592054 | 0.241984050016913 | 0.599105270847204 | -0.0432640316677283 | 6.50620878893071e-09 | 0.451793281105335 |
| FP | 0.220593955914386 | 0.0922679674047045 | 0.257597857375073 | 0.0852997180522231 | 2.6939591898569e-06 | 0.343408539927757 |
| IFG | 0.102785426530479 | 0.333950522970833 | 0.0873082233505654 | 0.348974736000808 | 0.0180576548329477 | 0.468902042971422 |
| PG | 0.825870450807634 | -0.0162396615808493 | 0.982933503289791 | -0.00157913161696503 | 5.26940261086197e-10 | 0.435411221371868 |
| STG | 0.43291613195784 | 0.08670230113124 | 0.30923501280753 | -0.112276147905534 | 0.00273837044719529 | 0.322890405229245 |
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Relation with AD stages for ANO7 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for ANO7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANO7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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