ADeditome: functional annotation of RNA A-to-I editing in AD

Gene summary for OPRD1

Gene summary

Gene information	Gene symbol	OPRD1
	Gene ID	4985
	Gene name	opioid receptor delta 1
	Synonyms	DOP\|DOR\|DOR1\|OPRD
	Cytomap	1p35.3
	Type of gene	protein-coding
	Description	delta-type opioid receptorD-OR-1DOR-1delta opioid receptor 1opioid receptor delta 1 isoform DOR-1Bopioid receptor delta 1 isoform DOR-1Copioid receptor delta 1 isoform DOR-1Dopioid receptor delta 1 isoform DOR-1E
	Modification date	20200313
	UniProtAcc	P41143,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
OPRD1	GO:0007186	G protein-coupled receptor signaling pathway	16325578
OPRD1	GO:0010629	negative regulation of gene expression	24613828
OPRD1	GO:0031333	negative regulation of protein complex assembly	24613828
OPRD1	GO:0033138	positive regulation of peptidyl-serine phosphorylation	24613828
OPRD1	GO:0051881	regulation of mitochondrial membrane potential	24613828
OPRD1	GO:0071456	cellular response to hypoxia	24613828
OPRD1	GO:0097237	cellular response to toxic substance	24613828

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RNA A-to-I events for OPRD1

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_94690(28820455, +), ADediting_94691(28820757, +), ADediting_94692(28822131, +), ADediting_94693(28822621, +), ADediting_94694(28823579, +), ADediting_94695(28823713, +), ADediting_94696(28824129, +), ADediting_94697(28825041, +), ADediting_94698(28825486, +), ADediting_94699(28825515, +), ADediting_94700(28825525, +), ADediting_94701(28826377, +), ADediting_94702(28827061, +), ADediting_94703(28827062, +), ADediting_94704(28828589, +), ADediting_94705(28829947, +), ADediting_94706(28830268, +), ADediting_94707(28831388, +), ADediting_94708(28831402, +), ADediting_94709(28831657, +), ADediting_94710(28837425, +), ADediting_94711(28837555, +), ADediting_94712(28837771, +), ADediting_94713(28837776, +), ADediting_94714(28840317, +), ADediting_94715(28840323, +), ADediting_94716(28840371, +), ADediting_94717(28842191, +), ADediting_94718(28842790, +), ADediting_94719(28842796, +), ADediting_94720(28842806, +), ADediting_94721(28844559, +), ADediting_94722(28845302, +), ADediting_94723(28845366, +), ADediting_94724(28847687, +), ADediting_94725(28847707, +), ADediting_94726(28847714, +), ADediting_94727(28849148, +), ADediting_94728(28850087, +), ADediting_94729(28850298, +), ADediting_94730(28850585, +), ADediting_94731(28850597, +), ADediting_94732(28850642, +), ADediting_94733(28851598, +), ADediting_94734(28851616, +), ADediting_94735(28852798, +), ADediting_94736(28853841, +), ADediting_94737(28853859, +), ADediting_94738(28860093, +), ADediting_94739(28860109, +), ADediting_94740(28860110, +), ADediting_94741(28860131, +), ADediting_94742(28860155, +), ADediting_94743(28860189, +), ADediting_94744(28860320, +), ADediting_94745(28860330, +), ADediting_94746(28861557, +), ADediting_94747(28861683, +), ADediting_94748(28861976, +), ADediting_94749(28862041, +), ADediting_94750(28862051, +), ADediting_94751(28862124, +), ADediting_94752(28862191, +), ADediting_94753(28864013, +), ADediting_94754(28864019, +), ADediting_94755(28864022, +), ADediting_94756(28864040, +), ADediting_94757(28864110, +), ADediting_94758(28864121, +), ADediting_94759(28864125, +), ADediting_94760(28864187, +), ADediting_94761(28864249, +), ADediting_94762(28864250, +), ADediting_94763(28867077, +), ADediting_94764(28867120, +), ADediting_94765(28867284, +), ADediting_94766(28867305, +), ADediting_94767(28867466, +), ADediting_94768(28867467, +), ADediting_94769(28867479, +), ADediting_94770(28867577, +), ADediting_94771(28867603, +), ADediting_94772(28867604, +), ADediting_94773(28867607, +), ADediting_94774(28867616, +), ADediting_94775(28868226, +), ADediting_94776(28868578, +), ADediting_94777(28868586, +), ADediting_94778(28868587, +), ADediting_94779(28868592, +), ADediting_94780(28868608, +), ADediting_94781(28868609, +), ADediting_94782(28868638, +), ADediting_94783(28868653, +), ADediting_94784(28868693, +), ADediting_94785(28868697, +), ADediting_94786(28868720, +), ADediting_94787(28868729, +), ADediting_94788(28868752, +), ADediting_94789(28868760, +), ADediting_94790(28868761, +), ADediting_94791(28868769, +), ADediting_94792(28868772, +), ADediting_94793(28868779, +), ADediting_94794(28868781, +), ADediting_94795(28868789, +), ADediting_94796(28868790, +), ADediting_94797(28870283, +), ADediting_94798(28870308, +), ADediting_94799(28870331, +), ADediting_94800(28870332, +), ADediting_94801(28870351, +), ADediting_94802(28870352, +), ADediting_94803(28870356, +), ADediting_94804(28870369, +), ADediting_94805(28870417, +), ADediting_94806(28870423, +), ADediting_94807(28870426, +), ADediting_94808(28870452, +), ADediting_1600382(28818841, +), ADediting_1600383(28862178, +),

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RNA editing positional annotations for OPRD1 using Annovar

Protein coding RNA editing(s).

ADeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_94690	chr1_28820455_+	intronic
ADediting_94691	chr1_28820757_+	intronic
ADediting_94692	chr1_28822131_+	intronic
ADediting_94693	chr1_28822621_+	intronic
ADediting_94694	chr1_28823579_+	intronic
ADediting_94695	chr1_28823713_+	intronic
ADediting_94696	chr1_28824129_+	intronic
ADediting_94697	chr1_28825041_+	intronic
ADediting_94698	chr1_28825486_+	intronic
ADediting_94699	chr1_28825515_+	intronic
ADediting_94700	chr1_28825525_+	intronic
ADediting_94701	chr1_28826377_+	intronic
ADediting_94702	chr1_28827061_+	intronic
ADediting_94703	chr1_28827062_+	intronic
ADediting_94704	chr1_28828589_+	intronic
ADediting_94705	chr1_28829947_+	intronic
ADediting_94706	chr1_28830268_+	intronic
ADediting_94707	chr1_28831388_+	intronic
ADediting_94708	chr1_28831402_+	intronic
ADediting_94709	chr1_28831657_+	intronic
ADediting_94710	chr1_28837425_+	intronic
ADediting_94711	chr1_28837555_+	intronic
ADediting_94712	chr1_28837771_+	intronic
ADediting_94713	chr1_28837776_+	intronic
ADediting_94714	chr1_28840317_+	intronic
ADediting_94715	chr1_28840323_+	intronic
ADediting_94716	chr1_28840371_+	intronic
ADediting_94717	chr1_28842191_+	intronic
ADediting_94718	chr1_28842790_+	intronic
ADediting_94719	chr1_28842796_+	intronic
ADediting_94720	chr1_28842806_+	intronic
ADediting_94721	chr1_28844559_+	intronic
ADediting_94722	chr1_28845302_+	intronic
ADediting_94723	chr1_28845366_+	intronic
ADediting_94724	chr1_28847687_+	intronic
ADediting_94725	chr1_28847707_+	intronic
ADediting_94726	chr1_28847714_+	intronic
ADediting_94727	chr1_28849148_+	intronic
ADediting_94728	chr1_28850087_+	intronic
ADediting_94729	chr1_28850298_+	intronic
ADediting_94730	chr1_28850585_+	intronic
ADediting_94731	chr1_28850597_+	intronic
ADediting_94732	chr1_28850642_+	intronic
ADediting_94733	chr1_28851598_+	intronic
ADediting_94734	chr1_28851616_+	intronic
ADediting_94735	chr1_28852798_+	intronic
ADediting_94736	chr1_28853841_+	intronic
ADediting_94737	chr1_28853859_+	intronic
ADediting_94738	chr1_28860093_+	intronic
ADediting_94739	chr1_28860109_+	intronic
ADediting_94740	chr1_28860110_+	intronic
ADediting_94741	chr1_28860131_+	intronic
ADediting_94742	chr1_28860155_+	intronic
ADediting_94743	chr1_28860189_+	intronic
ADediting_94744	chr1_28860320_+	intronic
ADediting_94745	chr1_28860330_+	intronic
ADediting_94746	chr1_28861557_+	intronic
ADediting_94747	chr1_28861683_+	intronic
ADediting_94748	chr1_28861976_+	intronic
ADediting_94749	chr1_28862041_+	intronic
ADediting_94750	chr1_28862051_+	intronic
ADediting_94751	chr1_28862124_+	intronic
ADediting_94752	chr1_28862191_+	intronic
ADediting_94753	chr1_28864013_+	UTR3
ADediting_94754	chr1_28864019_+	UTR3
ADediting_94755	chr1_28864022_+	UTR3
ADediting_94756	chr1_28864040_+	UTR3
ADediting_94757	chr1_28864110_+	UTR3
ADediting_94758	chr1_28864121_+	UTR3
ADediting_94759	chr1_28864125_+	UTR3
ADediting_94760	chr1_28864187_+	UTR3
ADediting_94761	chr1_28864249_+	UTR3
ADediting_94762	chr1_28864250_+	UTR3
ADediting_94763	chr1_28867077_+	UTR3
ADediting_94764	chr1_28867120_+	UTR3
ADediting_94765	chr1_28867284_+	UTR3
ADediting_94766	chr1_28867305_+	UTR3
ADediting_94767	chr1_28867466_+	UTR3
ADediting_94768	chr1_28867467_+	UTR3
ADediting_94769	chr1_28867479_+	UTR3
ADediting_94770	chr1_28867577_+	UTR3
ADediting_94771	chr1_28867603_+	UTR3
ADediting_94772	chr1_28867604_+	UTR3
ADediting_94773	chr1_28867607_+	UTR3
ADediting_94774	chr1_28867616_+	UTR3
ADediting_94775	chr1_28868226_+	UTR3
ADediting_94776	chr1_28868578_+	UTR3
ADediting_94777	chr1_28868586_+	UTR3
ADediting_94778	chr1_28868587_+	UTR3
ADediting_94779	chr1_28868592_+	UTR3
ADediting_94780	chr1_28868608_+	UTR3
ADediting_94781	chr1_28868609_+	UTR3
ADediting_94782	chr1_28868638_+	UTR3
ADediting_94783	chr1_28868653_+	UTR3
ADediting_94784	chr1_28868693_+	UTR3
ADediting_94785	chr1_28868697_+	UTR3
ADediting_94786	chr1_28868720_+	UTR3
ADediting_94787	chr1_28868729_+	UTR3
ADediting_94788	chr1_28868752_+	UTR3
ADediting_94789	chr1_28868760_+	UTR3
ADediting_94790	chr1_28868761_+	UTR3
ADediting_94791	chr1_28868769_+	UTR3
ADediting_94792	chr1_28868772_+	UTR3
ADediting_94793	chr1_28868779_+	UTR3
ADediting_94794	chr1_28868781_+	UTR3
ADediting_94795	chr1_28868789_+	UTR3
ADediting_94796	chr1_28868790_+	UTR3
ADediting_94797	chr1_28870283_+	UTR3
ADediting_94798	chr1_28870308_+	UTR3
ADediting_94799	chr1_28870331_+	UTR3
ADediting_94800	chr1_28870332_+	UTR3
ADediting_94801	chr1_28870351_+	UTR3
ADediting_94802	chr1_28870352_+	UTR3
ADediting_94803	chr1_28870356_+	UTR3
ADediting_94804	chr1_28870369_+	UTR3
ADediting_94805	chr1_28870417_+	UTR3
ADediting_94806	chr1_28870423_+	UTR3
ADediting_94807	chr1_28870426_+	UTR3
ADediting_94808	chr1_28870452_+	UTR3
ADediting_1600382	chr1_28818841_+	intronic
ADediting_1600383	chr1_28862178_+	intronic

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_94690	chr1_28820455_+	SINE	Alu	Name=AluSz
ADediting_94691	chr1_28820757_+	SINE	Alu	Name=AluJr4
ADediting_94692	chr1_28822131_+	SINE	Alu	Name=AluSp
ADediting_94693	chr1_28822621_+	SINE	Alu	Name=AluSz
ADediting_94694	chr1_28823579_+	SINE	Alu	Name=AluSg
ADediting_94695	chr1_28823713_+	SINE	Alu	Name=AluSx
ADediting_94696	chr1_28824129_+	SINE	Alu	Name=AluSz
ADediting_94697	chr1_28825041_+	SINE	Alu	Name=AluY
ADediting_94698	chr1_28825486_+	SINE	Alu	Name=AluSg
ADediting_94699	chr1_28825515_+	SINE	Alu	Name=AluSg
ADediting_94700	chr1_28825525_+	SINE	Alu	Name=AluSg
ADediting_94701	chr1_28826377_+	SINE	Alu	Name=AluJb
ADediting_94702	chr1_28827061_+	SINE	Alu	Name=AluJb
ADediting_94703	chr1_28827062_+	SINE	Alu	Name=AluJb
ADediting_94704	chr1_28828589_+	SINE	Alu	Name=FRAM
ADediting_94705	chr1_28829947_+	SINE	Alu	Name=AluJo
ADediting_94706	chr1_28830268_+	SINE	Alu	Name=AluJb
ADediting_94707	chr1_28831388_+	SINE	Alu	Name=AluSc
ADediting_94708	chr1_28831402_+	SINE	Alu	Name=AluSc
ADediting_94709	chr1_28831657_+	SINE	Alu	Name=AluJb
ADediting_94710	chr1_28837425_+	SINE	Alu	Name=AluSc
ADediting_94711	chr1_28837555_+	SINE	Alu	Name=AluSc
ADediting_94712	chr1_28837771_+	SINE	Alu	Name=AluJb
ADediting_94713	chr1_28837776_+	SINE	Alu	Name=AluJb
ADediting_94714	chr1_28840317_+	SINE	Alu	Name=AluJr
ADediting_94715	chr1_28840323_+	SINE	Alu	Name=AluJr
ADediting_94716	chr1_28840371_+	SINE	Alu	Name=AluJr
ADediting_94717	chr1_28842191_+	SINE	Alu	Name=AluJb
ADediting_94718	chr1_28842790_+	SINE	Alu	Name=AluJo
ADediting_94719	chr1_28842796_+	SINE	Alu	Name=AluJo
ADediting_94720	chr1_28842806_+	SINE	Alu	Name=AluJo
ADediting_94721	chr1_28844559_+	SINE	Alu	Name=AluJb
ADediting_94722	chr1_28845302_+	SINE	Alu	Name=AluSx1
ADediting_94723	chr1_28845366_+	SINE	Alu	Name=AluSx1
ADediting_94724	chr1_28847687_+	SINE	Alu	Name=AluJb
ADediting_94725	chr1_28847707_+	SINE	Alu	Name=AluJb
ADediting_94726	chr1_28847714_+	SINE	Alu	Name=AluJb
ADediting_94727	chr1_28849148_+	SINE	Alu	Name=AluJo
ADediting_94728	chr1_28850087_+	SINE	Alu	Name=AluYm1
ADediting_94729	chr1_28850298_+	SINE	Alu	Name=AluJr
ADediting_94730	chr1_28850585_+	SINE	Alu	Name=AluSp
ADediting_94731	chr1_28850597_+	SINE	Alu	Name=AluSp
ADediting_94732	chr1_28850642_+	SINE	Alu	Name=AluJr
ADediting_94733	chr1_28851598_+	SINE	Alu	Name=AluSp
ADediting_94734	chr1_28851616_+	SINE	Alu	Name=AluSp
ADediting_94735	chr1_28852798_+	SINE	Alu	Name=AluSq
ADediting_94736	chr1_28853841_+	SINE	Alu	Name=AluJb
ADediting_94737	chr1_28853859_+	SINE	Alu	Name=AluJb
ADediting_94738	chr1_28860093_+	SINE	Alu	Name=AluSx1
ADediting_94739	chr1_28860109_+	SINE	Alu	Name=AluSx1
ADediting_94740	chr1_28860110_+	SINE	Alu	Name=AluSx1
ADediting_94741	chr1_28860131_+	SINE	Alu	Name=AluSx1
ADediting_94742	chr1_28860155_+	SINE	Alu	Name=AluSx1
ADediting_94743	chr1_28860189_+	SINE	Alu	Name=AluSx1
ADediting_94744	chr1_28860320_+	SINE	Alu	Name=AluSx1
ADediting_94745	chr1_28860330_+	SINE	Alu	Name=AluSx1
ADediting_94746	chr1_28861557_+	SINE	Alu	Name=AluJb
ADediting_94747	chr1_28861683_+	SINE	Alu	Name=AluJb
ADediting_94748	chr1_28861976_+	SINE	Alu	Name=AluY
ADediting_94749	chr1_28862041_+	SINE	Alu	Name=AluY
ADediting_94750	chr1_28862051_+	SINE	Alu	Name=AluY
ADediting_94751	chr1_28862124_+	SINE	Alu	Name=AluY
ADediting_94752	chr1_28862191_+	SINE	Alu	Name=AluY
ADediting_94753	chr1_28864013_+	SINE	Alu	Name=AluJo
ADediting_94754	chr1_28864019_+	SINE	Alu	Name=AluJo
ADediting_94755	chr1_28864022_+	SINE	Alu	Name=AluJo
ADediting_94756	chr1_28864040_+	SINE	Alu	Name=AluJo
ADediting_94757	chr1_28864110_+	SINE	Alu	Name=AluJo
ADediting_94758	chr1_28864121_+	SINE	Alu	Name=AluJo
ADediting_94759	chr1_28864125_+	SINE	Alu	Name=AluJo
ADediting_94760	chr1_28864187_+	SINE	Alu	Name=AluJo
ADediting_94761	chr1_28864249_+	SINE	Alu	Name=AluJo
ADediting_94762	chr1_28864250_+	SINE	Alu	Name=AluJo
ADediting_94763	chr1_28867077_+	SINE	Alu	Name=AluJr
ADediting_94764	chr1_28867120_+	SINE	Alu	Name=AluJr
ADediting_94765	chr1_28867284_+	SINE	Alu	Name=AluSx
ADediting_94766	chr1_28867305_+	SINE	Alu	Name=AluSx
ADediting_94767	chr1_28867466_+	SINE	Alu	Name=AluSx
ADediting_94768	chr1_28867467_+	SINE	Alu	Name=AluSx
ADediting_94769	chr1_28867479_+	SINE	Alu	Name=AluSx
ADediting_94770	chr1_28867577_+	SINE	Alu	Name=AluJr
ADediting_94771	chr1_28867603_+	SINE	Alu	Name=AluJr
ADediting_94772	chr1_28867604_+	SINE	Alu	Name=AluJr
ADediting_94773	chr1_28867607_+	SINE	Alu	Name=AluJr
ADediting_94774	chr1_28867616_+	SINE	Alu	Name=AluJr
ADediting_94775	chr1_28868226_+	SINE	MIR	Name=MIR3
ADediting_94776	chr1_28868578_+	SINE	Alu	Name=AluSg
ADediting_94777	chr1_28868586_+	SINE	Alu	Name=AluSg
ADediting_94778	chr1_28868587_+	SINE	Alu	Name=AluSg
ADediting_94779	chr1_28868592_+	SINE	Alu	Name=AluSg
ADediting_94780	chr1_28868608_+	SINE	Alu	Name=AluSg
ADediting_94781	chr1_28868609_+	SINE	Alu	Name=AluSg
ADediting_94782	chr1_28868638_+	SINE	Alu	Name=AluSg
ADediting_94783	chr1_28868653_+	SINE	Alu	Name=AluSg
ADediting_94784	chr1_28868693_+	SINE	Alu	Name=AluSg
ADediting_94785	chr1_28868697_+	SINE	Alu	Name=AluSg
ADediting_94786	chr1_28868720_+	SINE	Alu	Name=AluSg
ADediting_94787	chr1_28868729_+	SINE	Alu	Name=AluSg
ADediting_94788	chr1_28868752_+	SINE	Alu	Name=AluSg
ADediting_94789	chr1_28868760_+	SINE	Alu	Name=AluSg
ADediting_94790	chr1_28868761_+	SINE	Alu	Name=AluSg
ADediting_94791	chr1_28868769_+	SINE	Alu	Name=AluSg
ADediting_94792	chr1_28868772_+	SINE	Alu	Name=AluSg
ADediting_94793	chr1_28868779_+	SINE	Alu	Name=AluSg
ADediting_94794	chr1_28868781_+	SINE	Alu	Name=AluSg
ADediting_94795	chr1_28868789_+	SINE	Alu	Name=AluSg
ADediting_94796	chr1_28868790_+	SINE	Alu	Name=AluSg
ADediting_94797	chr1_28870283_+	SINE	Alu	Name=AluSz
ADediting_94798	chr1_28870308_+	SINE	Alu	Name=AluSz
ADediting_94799	chr1_28870331_+	SINE	Alu	Name=AluSz
ADediting_94800	chr1_28870332_+	SINE	Alu	Name=AluSz
ADediting_94801	chr1_28870351_+	SINE	Alu	Name=AluSz
ADediting_94802	chr1_28870352_+	SINE	Alu	Name=AluSz
ADediting_94803	chr1_28870356_+	SINE	Alu	Name=AluSz
ADediting_94804	chr1_28870369_+	SINE	Alu	Name=AluSz
ADediting_94805	chr1_28870417_+	SINE	Alu	Name=AluSz
ADediting_94806	chr1_28870423_+	SINE	Alu	Name=AluSz
ADediting_94807	chr1_28870426_+	SINE	Alu	Name=AluSz
ADediting_94808	chr1_28870452_+	SINE	Alu	Name=AluSz
ADediting_1600383	chr1_28862178_+	SINE	Alu	Name=AluY

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RNA A-to-I editing events in the alternative splicing sites for OPRD1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

ADeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for OPRD1

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

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Protein coding region RNA A-to-I editings for OPRD1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for OPRD1

RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_94753	chr1_28864013_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-513a-5p	chr1	28864007	28864013	7mer-m8	28863997	28864014	144	-16.68
ADediting_94753	chr1_28864013_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-638	chr1	28864012	28864018	7mer-1a	28863994	28864018	151	-34.4
ADediting_94754	chr1_28864019_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-371a-3p	chr1	28864017	28864023	7mer-m8	28863998	28864024	147	-19.81
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-518a-3p	chr1	28864019	28864025	7mer-m8	28864005	28864026	145	-17.15
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-518b	chr1	28864019	28864025	7mer-m8	28864006	28864026	146	-21.79
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-518c-3p	chr1	28864019	28864025	7mer-m8	28864005	28864026	146	-18.11
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-518d-3p	chr1	28864019	28864025	7mer-m8	28864006	28864026	145	-17.84
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-518e-3p	chr1	28864018	28864024	7mer-m8	28864004	28864025	144	-14.65
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-518f-3p	chr1	28864019	28864025	7mer-m8	28864006	28864026	145	-17.48
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-526a-3p	chr1	28864019	28864025	7mer-m8	28864006	28864026	146	-17.71
ADediting_94758	chr1_28864121_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-3190-5p	chr1	28864119	28864125	7mer-m8	28864107	28864126	147	-16.24
ADediting_94758	chr1_28864121_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-548s	chr1	28864118	28864124	7mer-m8	28864103	28864125	157	-11.45
ADediting_94760	chr1_28864187_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-1247-3p	chr1	28864182	28864189	8mer-1a	28864165	28864189	144	-21.09
ADediting_94761	chr1_28864249_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6794-3p	chr1	28864243	28864249	7mer-m8	28864233	28864250	158	-26.32
ADediting_94763	chr1_28867077_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6807-5p	chr1	28867075	28867081	7mer-m8	28867063	28867082	146	-17.99
ADediting_94764	chr1_28867120_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6765-5p	chr1	28867118	28867124	7mer-m8	28867101	28867125	151	-24.76
ADediting_94766	chr1_28867305_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-3661	chr1	28867302	28867308	7mer-1a	28867287	28867308	140	-22.88
ADediting_94766	chr1_28867305_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-631	chr1	28867302	28867308	7mer-1a	28867287	28867308	140	-21.3
ADediting_94767	chr1_28867466_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-204-3p	chr1	28867459	28867466	8mer-1a	28867447	28867466	150	-21.04
ADediting_94767	chr1_28867466_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-3192-5p	chr1	28867460	28867466	7mer-1a	28867444	28867466	146	-28.4
ADediting_94767	chr1_28867466_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-326	chr1	28867461	28867467	7mer-m8	28867449	28867468	140	-13.25
ADediting_94767	chr1_28867466_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-330-5p	chr1	28867461	28867467	7mer-m8	28867445	28867468	143	-19.88
ADediting_94767	chr1_28867466_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4314	chr1	28867460	28867466	7mer-m8	28867449	28867467	151	-21.36
ADediting_94767	chr1_28867466_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4646-5p	chr1	28867459	28867466	8mer-1a	28867445	28867466	159	-27.87
ADediting_94767	chr1_28867466_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-514a-5p	chr1	28867462	28867468	7mer-m8	28867446	28867469	154	-17.53
ADediting_94768	chr1_28867467_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-3189-3p	chr1	28867461	28867467	7mer-m8	28867446	28867468	153	-25.7
ADediting_94768	chr1_28867467_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6813-3p	chr1	28867462	28867468	7mer-m8	28867449	28867469	140	-10.68
ADediting_94770	chr1_28867577_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-544b	chr1	28867571	28867577	7mer-m8	28867558	28867578	149	-13.73
ADediting_94771	chr1_28867603_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-326	chr1	28867598	28867604	7mer-m8	28867586	28867605	140	-15.33
ADediting_94771	chr1_28867603_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-330-5p	chr1	28867598	28867604	7mer-m8	28867584	28867605	140	-22.45
ADediting_94771	chr1_28867603_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4314	chr1	28867597	28867603	7mer-m8	28867587	28867604	140	-18.79
ADediting_94771	chr1_28867603_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-514a-5p	chr1	28867599	28867606	8mer-1a	28867586	28867606	154	-19.41
ADediting_94772	chr1_28867604_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-3189-3p	chr1	28867598	28867604	7mer-m8	28867586	28867605	141	-22.4
ADediting_94772	chr1_28867604_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6813-3p	chr1	28867599	28867606	8mer-1a	28867586	28867606	140	-13.48
ADediting_94773	chr1_28867607_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-383-3p	chr1	28867603	28867609	7mer-m8	28867590	28867610	144	-19.36
ADediting_94776	chr1_28868578_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4634	chr1	28868575	28868581	7mer-m8	28868564	28868582	145	-20.24
ADediting_94777	chr1_28868586_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-513a-5p	chr1	28868580	28868586	7mer-m8	28868570	28868587	144	-16.68
ADediting_94778	chr1_28868587_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-3117-3p	chr1	28868585	28868591	7mer-m8	28868572	28868592	142	-14.32
ADediting_94778	chr1_28868587_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4759	chr1	28868584	28868591	8mer-1a	28868571	28868591	149	-15.8
ADediting_94779	chr1_28868592_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-5006-5p	chr1	28868588	28868594	7mer-m8	28868575	28868595	154	-24.47
ADediting_94781	chr1_28868609_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-3176	chr1	28868602	28868608	7mer-m8	28868591	28868609	140	-15.24
ADediting_94781	chr1_28868609_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-3922-3p	chr1	28868602	28868608	7mer-m8	28868588	28868609	141	-17.02
ADediting_94784	chr1_28868693_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-3190-5p	chr1	28868691	28868697	7mer-m8	28868679	28868698	143	-16.24
ADediting_94784	chr1_28868693_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-548s	chr1	28868690	28868696	7mer-m8	28868675	28868697	149	-10.77
ADediting_94786	chr1_28868720_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-8052	chr1	28868718	28868724	7mer-1a	28868704	28868724	149	-25.19
ADediting_94787	chr1_28868729_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-1207-3p	chr1	28868722	28868728	7mer-m8	28868712	28868729	140	-12.56
ADediting_94787	chr1_28868729_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-646	chr1	28868724	28868730	7mer-m8	28868713	28868731	145	-14.99
ADediting_94788	chr1_28868752_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4431	chr1	28868748	28868754	7mer-m8	28868734	28868755	140	-17.94
ADediting_94790	chr1_28868761_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-10400-3p	chr1	28868758	28868764	7mer-m8	28868746	28868765	145	-25.98
ADediting_94790	chr1_28868761_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-24-3p	chr1	28868756	28868762	7mer-m8	28868742	28868763	140	-18.3
ADediting_94790	chr1_28868761_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-3934-3p	chr1	28868755	28868761	7mer-m8	28868741	28868762	143	-16.53
ADediting_94790	chr1_28868761_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4437	chr1	28868757	28868764	8mer-1a	28868744	28868764	150	-22.53
ADediting_94790	chr1_28868761_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4674	chr1	28868758	28868764	7mer-m8	28868746	28868765	152	-27.57
ADediting_94791	chr1_28868769_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-5001-3p	chr1	28868767	28868773	7mer-m8	28868750	28868774	157	-24.22
ADediting_94791	chr1_28868769_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-660-3p	chr1	28868763	28868769	7mer-m8	28868749	28868770	162	-20.03
ADediting_94791	chr1_28868769_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6791-3p	chr1	28868764	28868771	8mer-1a	28868752	28868771	165	-25.98
ADediting_94791	chr1_28868769_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6829-3p	chr1	28868764	28868771	8mer-1a	28868752	28868771	144	-20.8
ADediting_94791	chr1_28868769_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6836-3p	chr1	28868765	28868771	7mer-m8	28868752	28868772	140	-16.78
ADediting_94793	chr1_28868779_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4772-3p	chr1	28868775	28868781	7mer-m8	28868760	28868782	154	-19.41
ADediting_94795	chr1_28868789_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4638-5p	chr1	28868784	28868791	8mer-1a	28868770	28868791	148	-20.28
ADediting_94796	chr1_28868790_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-149-5p	chr1	28868783	28868789	7mer-m8	28868768	28868790	156	-22.86
ADediting_94798	chr1_28870308_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-324-3p	chr1	28870304	28870310	7mer-m8	28870287	28870311	144	-18.9
ADediting_94798	chr1_28870308_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4252	chr1	28870305	28870311	7mer-m8	28870292	28870312	150	-21.72
ADediting_94798	chr1_28870308_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4793-3p	chr1	28870301	28870307	7mer-m8	28870286	28870308	158	-22.35
ADediting_94800	chr1_28870332_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-17-3p	chr1	28870325	28870331	7mer-m8	28870311	28870332	150	-18.91
ADediting_94800	chr1_28870332_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-485-5p	chr1	28870329	28870335	7mer-m8	28870316	28870336	153	-19.07
ADediting_94800	chr1_28870332_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6884-5p	chr1	28870329	28870335	7mer-m8	28870313	28870336	150	-23.9
ADediting_94803	chr1_28870356_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-146a-5p	chr1	28870354	28870360	7mer-m8	28870339	28870361	147	-22.17
ADediting_94803	chr1_28870356_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-146b-5p	chr1	28870354	28870360	7mer-m8	28870339	28870361	145	-18.48
ADediting_94803	chr1_28870356_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-7153-5p	chr1	28870354	28870360	7mer-m8	28870338	28870361	146	-20.07
ADediting_94808	chr1_28870452_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-3940-3p	chr1	28870449	28870455	7mer-m8	28870438	28870456	146	-24.53

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_94753	chr1_28864013_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-10399-5p	chr1	28864008	28864014	7mer-m8	28863994	28864015	148	-11.36
ADediting_94753	chr1_28864013_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6504-3p	chr1	28864008	28864014	7mer-m8	28863994	28864015	148	-14.48
ADediting_94753	chr1_28864013_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-7151-3p	chr1	28864006	28864013	8mer-1a	28863993	28864013	152	-18.3
ADediting_94754	chr1_28864019_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-5089-5p	chr1	28864012	28864018	7mer-m8	28863999	28864019	145	-13.6
ADediting_94754	chr1_28864019_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-512-3p	chr1	28864017	28864023	7mer-m8	28864003	28864024	149	-15.03
ADediting_94754	chr1_28864019_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6506-5p	chr1	28864013	28864019	7mer-m8	28863998	28864020	144	-15.46
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-302a-3p	chr1	28864018	28864024	7mer-m8	28863998	28864025	144	-14.68
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-302b-3p	chr1	28864018	28864024	7mer-m8	28863998	28864025	148	-12.28
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-302c-3p	chr1	28864018	28864024	7mer-m8	28863998	28864025	148	-15.62
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-302e	chr1	28864018	28864024	7mer-m8	28864009	28864025	141	-8.62
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-512-3p	chr1	28864017	28864023	7mer-m8	28864003	28864024	149	-15.03
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-519d-3p	chr1	28864019	28864025	7mer-m8	28864006	28864026	146	-14.53
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-520a-3p	chr1	28864018	28864024	7mer-m8	28864003	28864025	143	-11.08
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-520b-3p	chr1	28864018	28864024	7mer-m8	28864006	28864025	141	-16.52
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-520c-3p	chr1	28864018	28864024	7mer-m8	28864005	28864025	146	-16.52
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-520d-3p	chr1	28864018	28864024	7mer-m8	28864004	28864025	140	-13.12
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-520e-3p	chr1	28864018	28864024	7mer-m8	28864005	28864025	140	-13.32
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-520g-3p	chr1	28864020	28864026	7mer-m8	28864005	28864027	151	-15.9
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-520h	chr1	28864020	28864026	7mer-m8	28864006	28864027	150	-15.08
ADediting_94755	chr1_28864022_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-526b-3p	chr1	28864019	28864025	7mer-m8	28864006	28864026	146	-16.66
ADediting_94756	chr1_28864040_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6747-3p	chr1	28864035	28864041	7mer-m8	28864021	28864042	150	-22.65
ADediting_94758	chr1_28864121_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4735-5p	chr1	28864115	28864121	7mer-m8	28864101	28864122	140	-4.47
ADediting_94758	chr1_28864121_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4794	chr1	28864119	28864125	7mer-m8	28864105	28864126	140	-12.3
ADediting_94758	chr1_28864121_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-664a-5p	chr1	28864119	28864125	7mer-m8	28864103	28864126	141	-13.45
ADediting_94759	chr1_28864125_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4794	chr1	28864119	28864125	7mer-m8	28864105	28864126	140	-12.3
ADediting_94759	chr1_28864125_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-664a-5p	chr1	28864119	28864125	7mer-m8	28864103	28864126	141	-13.45
ADediting_94760	chr1_28864187_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-1343-3p	chr1	28864183	28864189	7mer-m8	28864169	28864190	143	-21.85
ADediting_94760	chr1_28864187_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-450b-3p	chr1	28864180	28864186	7mer-m8	28864168	28864187	151	-21.27
ADediting_94760	chr1_28864187_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-619-5p	chr1	28864181	28864187	7mer-m8	28864168	28864188	151	-18.81
ADediting_94760	chr1_28864187_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6506-5p	chr1	28864181	28864187	7mer-m8	28864167	28864188	146	-12.71
ADediting_94760	chr1_28864187_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6783-3p	chr1	28864183	28864189	7mer-m8	28864164	28864190	145	-23.33
ADediting_94760	chr1_28864187_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-769-3p	chr1	28864180	28864186	7mer-m8	28864166	28864187	149	-22.82
ADediting_94761	chr1_28864249_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-200c-5p	chr1	28864246	28864252	7mer-m8	28864232	28864253	144	-13.64
ADediting_94761	chr1_28864249_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-550b-3p	chr1	28864244	28864251	8mer-1a	28864228	28864251	155	-27.13
ADediting_94762	chr1_28864250_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-200c-5p	chr1	28864246	28864252	7mer-m8	28864232	28864253	144	-13.64
ADediting_94762	chr1_28864250_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-550b-3p	chr1	28864244	28864251	8mer-1a	28864228	28864251	155	-27.13
ADediting_94765	chr1_28867284_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-106a-3p	chr1	28867277	28867284	8mer-1a	28867265	28867284	142	-10.21
ADediting_94765	chr1_28867284_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-377-5p	chr1	28867282	28867288	7mer-m8	28867266	28867289	150	-18.22
ADediting_94767	chr1_28867466_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-450a-1-3p	chr1	28867459	28867466	8mer-1a	28867445	28867466	140	-10.65
ADediting_94771	chr1_28867603_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-887-5p	chr1	28867596	28867603	8mer-1a	28867582	28867603	148	-16.93
ADediting_94773	chr1_28867607_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4712-5p	chr1	28867604	28867610	7mer-m8	28867590	28867611	140	-17.37
ADediting_94773	chr1_28867607_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-770-5p	chr1	28867604	28867610	7mer-m8	28867586	28867611	148	-23.97
ADediting_94775	chr1_28868226_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-8078	chr1	28868222	28868229	8mer-1a	28868204	28868229	144	-20.3
ADediting_94776	chr1_28868578_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6807-5p	chr1	28868571	28868577	7mer-m8	28868557	28868578	149	-20.18
ADediting_94777	chr1_28868586_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-10399-5p	chr1	28868581	28868587	7mer-m8	28868567	28868588	144	-10.39
ADediting_94777	chr1_28868586_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6504-3p	chr1	28868581	28868587	7mer-m8	28868567	28868588	152	-15.11
ADediting_94777	chr1_28868586_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-7151-3p	chr1	28868579	28868586	8mer-1a	28868566	28868586	144	-16.51
ADediting_94778	chr1_28868587_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-10399-5p	chr1	28868581	28868587	7mer-m8	28868567	28868588	144	-10.39
ADediting_94778	chr1_28868587_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6504-3p	chr1	28868581	28868587	7mer-m8	28868567	28868588	152	-15.11
ADediting_94780	chr1_28868608_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6878-3p	chr1	28868601	28868608	8mer-1a	28868588	28868608	142	-17.1
ADediting_94782	chr1_28868638_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-653-5p	chr1	28868634	28868640	7mer-m8	28868621	28868641	140	-15.2
ADediting_94783	chr1_28868653_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4781-3p	chr1	28868650	28868656	7mer-m8	28868636	28868657	140	-11.02
ADediting_94784	chr1_28868693_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4735-5p	chr1	28868687	28868693	7mer-m8	28868673	28868694	140	-5.48
ADediting_94784	chr1_28868693_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4794	chr1	28868691	28868697	7mer-m8	28868677	28868698	140	-12.55
ADediting_94784	chr1_28868693_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-664a-5p	chr1	28868691	28868697	7mer-m8	28868675	28868698	141	-13.84
ADediting_94785	chr1_28868697_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4794	chr1	28868691	28868697	7mer-m8	28868677	28868698	140	-12.55
ADediting_94785	chr1_28868697_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-664a-5p	chr1	28868691	28868697	7mer-m8	28868675	28868698	141	-13.84
ADediting_94786	chr1_28868720_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-10399-5p	chr1	28868714	28868720	7mer-m8	28868700	28868721	144	-11.89
ADediting_94786	chr1_28868720_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-5089-5p	chr1	28868718	28868724	7mer-m8	28868707	28868725	151	-15.32
ADediting_94786	chr1_28868720_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6504-3p	chr1	28868714	28868720	7mer-m8	28868700	28868721	151	-17.09
ADediting_94787	chr1_28868729_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6869-5p	chr1	28868726	28868732	7mer-m8	28868711	28868733	146	-17.48
ADediting_94788	chr1_28868752_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-629-3p	chr1	28868745	28868751	7mer-m8	28868732	28868752	152	-22.1
ADediting_94788	chr1_28868752_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-8053	chr1	28868750	28868756	7mer-m8	28868734	28868757	146	-18.21
ADediting_94791	chr1_28868769_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-516a-3p	chr1	28868764	28868771	8mer-1a	28868751	28868771	148	-19.19
ADediting_94791	chr1_28868769_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-516b-3p	chr1	28868764	28868771	8mer-1a	28868751	28868771	148	-19.19
ADediting_94791	chr1_28868769_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-7162-5p	chr1	28868764	28868771	8mer-1a	28868753	28868771	142	-17.28
ADediting_94792	chr1_28868772_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6728-3p	chr1	28868768	28868774	7mer-m8	28868753	28868775	143	-18.82
ADediting_94797	chr1_28870283_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6864-3p	chr1	28870276	28870282	7mer-m8	28870262	28870283	148	-15.76
ADediting_94797	chr1_28870283_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-759	chr1	28870281	28870287	7mer-m8	28870268	28870288	145	-15.6
ADediting_94798	chr1_28870308_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-32-5p	chr1	28870302	28870308	7mer-m8	28870287	28870309	151	-11.65
ADediting_94798	chr1_28870308_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-363-3p	chr1	28870302	28870308	7mer-m8	28870288	28870309	147	-13.63
ADediting_94799	chr1_28870331_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-377-5p	chr1	28870329	28870335	7mer-m8	28870313	28870336	150	-18.38
ADediting_94799	chr1_28870331_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6086	chr1	28870329	28870335	7mer-m8	28870317	28870336	150	-23.99
ADediting_94799	chr1_28870331_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6516-5p	chr1	28870325	28870331	7mer-m8	28870310	28870332	144	-13.65
ADediting_94800	chr1_28870332_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-377-5p	chr1	28870329	28870335	7mer-m8	28870313	28870336	150	-18.38
ADediting_94800	chr1_28870332_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6086	chr1	28870329	28870335	7mer-m8	28870317	28870336	150	-23.99
ADediting_94800	chr1_28870332_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-6516-5p	chr1	28870325	28870331	7mer-m8	28870310	28870332	144	-13.65
ADediting_94803	chr1_28870356_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-219b-3p	chr1	28870352	28870358	7mer-m8	28870339	28870359	153	-15.53
ADediting_94803	chr1_28870356_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-302f	chr1	28870351	28870357	7mer-m8	28870342	28870358	145	-8.09
ADediting_94804	chr1_28870369_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4478	chr1	28870366	28870372	7mer-m8	28870358	28870373	149	-21.13
ADediting_94804	chr1_28870369_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-4649-3p	chr1	28870363	28870369	7mer-m8	28870350	28870370	140	-14.11
ADediting_94804	chr1_28870369_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-7160-5p	chr1	28870364	28870370	7mer-m8	28870351	28870371	147	-20.02
ADediting_94808	chr1_28870452_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-3190-5p	chr1	28870446	28870452	7mer-m8	28870435	28870453	154	-22.63
ADediting_94808	chr1_28870452_+	ENSG00000116329.11	ENST00000234961.7	OPRD1-201	hsa-miR-548s	chr1	28870445	28870451	7mer-m8	28870430	28870452	154	-16.4

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_1097295

chr3_85385762_+

ENSG00000116329.11

ENST00000234961.7

OPRD1-201

hsa-miR-5688

chr1

28866277

28866283

7mer-m8

28866263

28866284

154

-14.15

ADediting_1337757

chr7_5495852_-

ENSG00000116329.11

ENST00000234961.7

OPRD1-201

hsa-miR-589-3p

chr1

28867031

28867037

7mer-m8

28867014

28867038

161

-16.99

ADediting_1337757

chr7_5495852_-

ENSG00000116329.11

ENST00000234961.7

OPRD1-201

hsa-miR-589-3p

chr1

28869722

28869729

8mer-1a

28869706

28869729

141

-18.37

ADediting_1391023

chr8_140732605_-

ENSG00000116329.11

ENST00000234961.7

OPRD1-201

hsa-miR-151a-3p

chr1

28868919

28868925

7mer-m8

28868906

28868926

151

-18.38

ADediting_1471003

chr9_63819626_+

ENSG00000116329.11

ENST00000234961.7

OPRD1-201

hsa-miR-4477b

chr1

28867570

28867576

7mer-m8

28867556

28867577

151

-15.84

ADediting_1471003

chr9_63819626_+

ENSG00000116329.11

ENST00000234961.7

OPRD1-201

hsa-miR-4477b

chr1

28868867

28868873

7mer-m8

28868852

28868874

163

-16.46

ADediting_1631458

chr19_40282624_-

ENSG00000116329.11

ENST00000234961.7

OPRD1-201

hsa-miR-641

chr1

28866966

28866973

8mer-1a

28866952

28866973

145

-12.47

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_1337758

chr7_5495892_-

ENSG00000116329.11

ENST00000234961.7

OPRD1-201

hsa-miR-589-5p

chr1

28866871

28866878

8mer-1a

28866856

28866878

151

-19.54

ADediting_1471003

chr9_63819626_+

ENSG00000116329.11

ENST00000234961.7

OPRD1-201

hsa-miR-4477b

chr1

28863597

28863604

8mer-1a

28863581

28863604

155

-12.27

ADediting_1471004

chr9_63819627_+

ENSG00000116329.11

ENST00000234961.7

OPRD1-201

hsa-miR-4477b

chr1

28863597

28863604

8mer-1a

28863581

28863604

155

-12.27

ADediting_1535953

chr14_101045971_+

ENSG00000116329.11

ENST00000234961.7

OPRD1-201

hsa-miR-381-3p

chr1

28866063

28866069

7mer-m8

28866049

28866070

144

-14.11

ADediting_1535954

chr14_101045974_+

ENSG00000116329.11

ENST00000234961.7

OPRD1-201

hsa-miR-381-3p

chr1

28866063

28866069

7mer-m8

28866049

28866070

144

-14.11

ADediting_1556067

chr19_40282625_-

ENSG00000116329.11

ENST00000234961.7

OPRD1-201

hsa-miR-641

chr1

28865399

28865405

7mer-m8

28865381

28865406

148

-14.7

ADediting_1596844

chr1_162342605_+

ENSG00000116329.11

ENST00000234961.7

OPRD1-201

hsa-miR-556-3p

chr1

28864441

28864448

8mer-1a

28864428

28864448

145

-8.56

ADediting_1631458

chr19_40282624_-

ENSG00000116329.11

ENST00000234961.7

OPRD1-201

hsa-miR-641

chr1

28865399

28865405

7mer-m8

28865381

28865406

148

-14.7

ADediting_527135

chr16_24203190_+

ENSG00000116329.11

ENST00000234961.7

OPRD1-201

hsa-miR-1273h-3p

chr1

28871260

28871266

7mer-m8

28871245

28871266

147

-18.29

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for OPRD1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000234961.7	protein_coding

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_94753	ENST00000234961.7	chr1_28864013_+	2063	-4122.40	-4122.30	-4194.60
ADediting_94754	ENST00000234961.7	chr1_28864019_+	2069	-4122.20	-4122.30	-4194.60
ADediting_94755	ENST00000234961.7	chr1_28864022_+	2072	-4121.90	-4122.30	-4194.60
ADediting_94756	ENST00000234961.7	chr1_28864040_+	2090	-4128.50	-4122.30	-4194.60
ADediting_94757	ENST00000234961.7	chr1_28864110_+	2160	-4122.40	-4122.30	-4194.60
ADediting_94758	ENST00000234961.7	chr1_28864121_+	2171	-4122.00	-4122.30	-4194.60
ADediting_94759	ENST00000234961.7	chr1_28864125_+	2175	-4128.40	-4122.30	-4194.60
ADediting_94760	ENST00000234961.7	chr1_28864187_+	2237	-4121.60	-4122.30	-4194.60
ADediting_94761	ENST00000234961.7	chr1_28864249_+	2299	-4125.50	-4122.30	-4194.60
ADediting_94762	ENST00000234961.7	chr1_28864250_+	2300	-4121.90	-4122.30	-4194.60
ADediting_94763	ENST00000234961.7	chr1_28867077_+	5127	-4122.20	-4122.30	-4194.60
ADediting_94764	ENST00000234961.7	chr1_28867120_+	5170	-4121.80	-4122.30	-4194.60
ADediting_94765	ENST00000234961.7	chr1_28867284_+	5334	-4122.60	-4122.30	-4194.60
ADediting_94766	ENST00000234961.7	chr1_28867305_+	5355	-4128.80	-4122.30	-4194.60
ADediting_94767	ENST00000234961.7	chr1_28867466_+	5516	-4122.40	-4122.30	-4194.60
ADediting_94768	ENST00000234961.7	chr1_28867467_+	5517	-4122.00	-4122.30	-4194.60
ADediting_94769	ENST00000234961.7	chr1_28867479_+	5529	-4122.30	-4122.30	-4194.60
ADediting_94770	ENST00000234961.7	chr1_28867577_+	5627	-4122.30	-4122.30	-4194.60
ADediting_94771	ENST00000234961.7	chr1_28867603_+	5653	-4123.30	-4122.30	-4194.60
ADediting_94772	ENST00000234961.7	chr1_28867604_+	5654	-4126.50	-4122.30	-4194.60
ADediting_94773	ENST00000234961.7	chr1_28867607_+	5657	-4124.90	-4122.30	-4194.60
ADediting_94774	ENST00000234961.7	chr1_28867616_+	5666	-4122.50	-4122.30	-4194.60
ADediting_94775	ENST00000234961.7	chr1_28868226_+	6276	-4123.30	-4122.30	-4194.60
ADediting_94776	ENST00000234961.7	chr1_28868578_+	6628	-4122.30	-4122.30	-4194.60
ADediting_94777	ENST00000234961.7	chr1_28868586_+	6636	-4122.40	-4122.30	-4194.60
ADediting_94778	ENST00000234961.7	chr1_28868587_+	6637	-4122.30	-4122.30	-4194.60
ADediting_94779	ENST00000234961.7	chr1_28868592_+	6642	-4122.00	-4122.30	-4194.60
ADediting_94780	ENST00000234961.7	chr1_28868608_+	6658	-4128.30	-4122.30	-4194.60
ADediting_94781	ENST00000234961.7	chr1_28868609_+	6659	-4122.20	-4122.30	-4194.60
ADediting_94782	ENST00000234961.7	chr1_28868638_+	6688	-4127.90	-4122.30	-4194.60
ADediting_94783	ENST00000234961.7	chr1_28868653_+	6703	-4122.00	-4122.30	-4194.60
ADediting_94784	ENST00000234961.7	chr1_28868693_+	6743	-4122.00	-4122.30	-4194.60
ADediting_94785	ENST00000234961.7	chr1_28868697_+	6747	-4128.50	-4122.30	-4194.60
ADediting_94786	ENST00000234961.7	chr1_28868720_+	6770	-4122.30	-4122.30	-4194.60
ADediting_94787	ENST00000234961.7	chr1_28868729_+	6779	-4122.30	-4122.30	-4194.60
ADediting_94788	ENST00000234961.7	chr1_28868752_+	6802	-4122.50	-4122.30	-4194.60
ADediting_94789	ENST00000234961.7	chr1_28868760_+	6810	-4121.80	-4122.30	-4194.60
ADediting_94790	ENST00000234961.7	chr1_28868761_+	6811	-4122.30	-4122.30	-4194.60
ADediting_94791	ENST00000234961.7	chr1_28868769_+	6819	-4128.80	-4122.30	-4194.60
ADediting_94792	ENST00000234961.7	chr1_28868772_+	6822	-4128.50	-4122.30	-4194.60
ADediting_94793	ENST00000234961.7	chr1_28868779_+	6829	-4129.00	-4122.30	-4194.60
ADediting_94794	ENST00000234961.7	chr1_28868781_+	6831	-4121.60	-4122.30	-4194.60
ADediting_94795	ENST00000234961.7	chr1_28868789_+	6839	-4128.30	-4122.30	-4194.60
ADediting_94796	ENST00000234961.7	chr1_28868790_+	6840	-4122.20	-4122.30	-4194.60
ADediting_94797	ENST00000234961.7	chr1_28870283_+	8333	-4127.70	-4122.30	-4194.60
ADediting_94798	ENST00000234961.7	chr1_28870308_+	8358	-4128.50	-4122.30	-4194.60
ADediting_94799	ENST00000234961.7	chr1_28870331_+	8381	-4122.70	-4122.30	-4194.60
ADediting_94800	ENST00000234961.7	chr1_28870332_+	8382	-4122.30	-4122.30	-4194.60
ADediting_94801	ENST00000234961.7	chr1_28870351_+	8401	-4124.80	-4122.30	-4194.60
ADediting_94802	ENST00000234961.7	chr1_28870352_+	8402	-4128.90	-4122.30	-4194.60
ADediting_94803	ENST00000234961.7	chr1_28870356_+	8406	-4124.70	-4122.30	-4194.60
ADediting_94804	ENST00000234961.7	chr1_28870369_+	8419	-4121.60	-4122.30	-4194.60
ADediting_94805	ENST00000234961.7	chr1_28870417_+	8467	-4128.50	-4122.30	-4194.60
ADediting_94806	ENST00000234961.7	chr1_28870423_+	8473	-4122.20	-4122.30	-4194.60
ADediting_94807	ENST00000234961.7	chr1_28870426_+	8476	-4122.00	-4122.30	-4194.60
ADediting_94808	ENST00000234961.7	chr1_28870452_+	8502	-4121.60	-4122.30	-4194.60

RNA A-to-I editing in lncRNA.

ADeditom_ID

ENST

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for OPRD1

Correlation between ADAR gene expression and RNA editing frequency

Tissue	ADeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	ADediting_94711	chr1_28837555_+	0.549967133254751	-0.0340811051974996	0.032667368997559	-0.121366503350411	2.97474252096585e-11	0.365876929633936
DLPFC	ADediting_94721	chr1_28844559_+	0.0264031085477651	-0.126106252053627	0.000538539809165673	-0.195451651396119	3.48920134000913e-09	0.327506654566422
DLPFC	ADediting_94722	chr1_28845302_+	0.0585155982198182	-0.107570475251649	0.000311771078838867	-0.20344459644277	3.08722236266788e-09	0.328560896145555
DLPFC	ADediting_94744	chr1_28860320_+	0.587154494216575	0.0309559535419273	0.165770511232445	-0.0789111058898537	1.21004808581469e-16	0.447139862227548
DLPFC	ADediting_94751	chr1_28862124_+	0.0576072347508308	0.107958241829173	0.832478075393688	0.0120620707897336	1.73233115757739e-12	0.38654838115746
TCX	ADediting_94760	chr1_28864187_+	1.8288623703857e-06	0.378184074492094	2.8204824302178e-06	0.371720680868029	0.628433801324564	0.0398304339642803
TCX	ADediting_94763	chr1_28867077_+	1.7933677072235e-06	0.37847322523674	3.36004954745376e-09	0.459374935208304	0.668488316752534	-0.0352483120277189
TCX	ADediting_94765	chr1_28867284_+	0.000149731193813876	0.304729185450733	7.86248379289138e-06	0.355844711384451	0.848615434081544	0.0157162330061592
TCX	ADediting_94766	chr1_28867305_+	0.00163927777453571	0.254970483830011	2.39663921836791e-06	0.374166534541284	0.152951536970712	-0.117270311605697
TCX	ADediting_94773	chr1_28867607_+	2.61917117430865e-05	0.336051692371286	2.14639014332065e-08	0.437610791405873	0.172508439413306	-0.111971561916318
STG	ADediting_94773	chr1_28867607_+	0.000140760187725851	0.403592159065079	0.00321663819537711	0.317843151105177	0.169203456938271	-0.151401783841045
TCX	ADediting_94774	chr1_28867616_+	2.06409968384368e-05	0.340076905078702	4.68286581837686e-07	0.397653563034272	0.332277097481215	-0.0797031324912623
STG	ADediting_94774	chr1_28867616_+	0.00199269997808075	0.332615444489952	3.5493716753365e-05	0.435003904139786	0.736573934455884	-0.0372489632264406
TCX	ADediting_94777	chr1_28868586_+	1.71778852914622e-07	0.411230333599291	3.49391414108621e-10	0.48402655628965	0.432742654954017	-0.064527740935764
TCX	ADediting_94778	chr1_28868587_+	0.000662644148755799	0.274907221943582	4.10060541282496e-05	0.328320123600574	0.184963900129028	-0.108825460122641
TCX	ADediting_94786	chr1_28868720_+	0.000338921548562022	0.28875533876531	2.98366591930307e-05	0.333825711347006	0.441194843824694	-0.063351458593216
TCX	ADediting_94792	chr1_28868772_+	3.61280441001573e-06	0.367963441107613	8.78022209572744e-08	0.419991669483885	0.309515648093089	-0.0835292099351071
TCX	ADediting_94793	chr1_28868779_+	4.04255795932362e-05	0.328569237695313	1.08883698802099e-06	0.385743211565194	0.217274626218851	-0.101328115540208
TCX	ADediting_94795	chr1_28868789_+	0.00268539888753392	0.243420855964892	1.24065033127955e-06	0.38385833376074	0.153297935560626	-0.117172161349657
TCX	ADediting_94806	chr1_28870423_+	2.74351759264772e-05	0.335261236754876	0.000293140019412152	0.291661591829503	0.691030766700252	0.0327172012465075

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	5.54992575338984e-17	0.4515792009167	8.31234110138318e-11	0.358028621467775	6.13726078177819e-19	0.476040735187898
AC	2.7677896734196e-20	0.539519031240268	4.50368281736483e-36	0.68572926024058	0.00104499772600596	0.206128779270998
PCC	2.79619020542793e-19	0.589755358440517	3.87183135639817e-29	0.697275809536682	0.629475470078507	0.0351297847400439
TCX	7.11367510146868e-24	0.705301303133228	1.83236842464413e-32	0.784074207534905	0.0288416501791774	-0.178514463580637
FP	5.4785231371916e-23	0.65275774402568	7.99624479218032e-37	0.774369519402697	0.0018990465010916	0.231239238637832
IFG	6.84382091383444e-05	0.710745145994614	3.40734261741139e-07	0.827234578346701	0.338982739899059	0.199517851897515
PG	5.71332362632254e-14	0.514651347807085	1.32759530220206e-28	0.699044571458954	0.0234467271443341	-0.166120424129046
STG	1.04196967917566e-15	0.738787333445087	3.61737252128495e-25	0.855611261261211	0.953899630522252	0.00640352115939074

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Relation with AD stages for OPRD1

Correlation between AD stages and RNA editing frequency

Tissue	ADeditomID	position	P-val	Coeff.
TCX	ADediting_94773	chr1_28867607_+	0.00164432604021201	0.302156434663229

Correlation between AD stages and this gene's expression

Tissue	P-val	Coeff.
CER	0.000106633725540601	0.364216712404328

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RelatedDrugs for OPRD1

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
OPRD1	P41143	DB00321	Amitriptyline	Delta-type opioid receptor	small molecule	approved
OPRD1	P41143	DB00333	Methadone	Delta-type opioid receptor	small molecule	approved
OPRD1	P41143	DB00514	Dextromethorphan	Delta-type opioid receptor	small molecule	approved
OPRD1	P41143	DB00836	Loperamide	Delta-type opioid receptor	small molecule	approved
OPRD1	P41143	DB00844	Nalbuphine	Delta-type opioid receptor	small molecule	approved
OPRD1	P41143	DB00899	Remifentanil	Delta-type opioid receptor	small molecule	approved
OPRD1	P41143	DB06204	Tapentadol	Delta-type opioid receptor	small molecule	approved
OPRD1	P41143	DB00318	Codeine	Delta-type opioid receptor	small molecule	approved\|illicit
OPRD1	P41143	DB00327	Hydromorphone	Delta-type opioid receptor	small molecule	approved\|illicit
OPRD1	P41143	DB01081	Diphenoxylate	Delta-type opioid receptor	small molecule	approved\|illicit
OPRD1	P41143	DB09209	Pholcodine	Delta-type opioid receptor	small molecule	approved\|illicit
OPRD1	P41143	DB11130	Opium	Delta-type opioid receptor	small molecule	approved\|illicit
OPRD1	P41143	DB00497	Oxycodone	Delta-type opioid receptor	small molecule	approved\|illicit\|investigational
OPRD1	P41143	DB00956	Hydrocodone	Delta-type opioid receptor	small molecule	approved\|illicit\|investigational
OPRD1	P41143	DB01452	Diamorphine	Delta-type opioid receptor	small molecule	approved\|illicit\|investigational
OPRD1	P41143	DB00813	Fentanyl	Delta-type opioid receptor	small molecule	approved\|illicit\|investigational\|vet_approved
OPRD1	P41143	DB00921	Buprenorphine	Delta-type opioid receptor	small molecule	approved\|illicit\|investigational\|vet_approved
OPRD1	P41143	DB00647	Dextropropoxyphene	Delta-type opioid receptor	small molecule	approved\|illicit\|investigational\|withdrawn
OPRD1	P41143	DB00611	Butorphanol	Delta-type opioid receptor	small molecule	approved\|illicit\|vet_approved
OPRD1	P41143	DB00193	Tramadol	Delta-type opioid receptor	small molecule	approved\|investigational
OPRD1	P41143	DB00295	Morphine	Delta-type opioid receptor	small molecule	approved\|investigational
OPRD1	P41143	DB00708	Sufentanil	Delta-type opioid receptor	small molecule	approved\|investigational
OPRD1	P41143	DB06274	Alvimopan	Delta-type opioid receptor	small molecule	approved\|investigational
OPRD1	P41143	DB09061	Cannabidiol	Delta-type opioid receptor	small molecule	approved\|investigational
OPRD1	P41143	DB09272	Eluxadoline	Delta-type opioid receptor	small molecule	approved\|investigational
OPRD1	P41143	DB11691	Naldemedine	Delta-type opioid receptor	small molecule	approved\|investigational
OPRD1	P41143	DB00704	Naltrexone	Delta-type opioid receptor	small molecule	approved\|investigational\|vet_approved
OPRD1	P41143	DB06230	Nalmefene	Delta-type opioid receptor	small molecule	approved\|investigational\|withdrawn
OPRD1	P41143	DB01183	Naloxone	Delta-type opioid receptor	small molecule	approved\|vet_approved
OPRD1	P41143	DB01221	Ketamine	Delta-type opioid receptor	small molecule	approved\|vet_approved

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RelatedDiseases for OPRD1

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
OPRD1	C0001973	Alcoholic Intoxication, Chronic	4	PSYGENET
OPRD1	C0013146	Drug abuse	2	CTD_human
OPRD1	C0013170	Drug habituation	2	CTD_human
OPRD1	C0013222	Drug Use Disorders	2	CTD_human
OPRD1	C0029231	Organic Mental Disorders, Substance-Induced	2	CTD_human
OPRD1	C0038580	Substance Dependence	2	CTD_human
OPRD1	C0038586	Substance Use Disorders	2	CTD_human
OPRD1	C0236969	Substance-Related Disorders	2	CTD_human
OPRD1	C0600427	Cocaine Dependence	2	PSYGENET
OPRD1	C0740858	Substance abuse problem	2	CTD_human
OPRD1	C1510472	Drug Dependence	2	CTD_human
OPRD1	C4316881	Prescription Drug Abuse	2	CTD_human
OPRD1	C0014544	Epilepsy	1	CTD_human
OPRD1	C0020651	Hypotension, Orthostatic	1	CTD_human
OPRD1	C0033975	Psychotic Disorders	1	PSYGENET
OPRD1	C0038587	Substance Withdrawal Syndrome	1	CTD_human
OPRD1	C0086189	Drug Withdrawal Symptoms	1	CTD_human
OPRD1	C0086237	Epilepsy, Cryptogenic	1	CTD_human
OPRD1	C0087169	Withdrawal Symptoms	1	CTD_human
OPRD1	C0236018	Aura	1	CTD_human
OPRD1	C0349204	Nonorganic psychosis	1	PSYGENET
OPRD1	C0751111	Awakening Epilepsy	1	CTD_human

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Gene summary for OPRD1

RNA A-to-I events for OPRD1

RNA editing positional annotations for OPRD1 using Annovar

RNA A-to-I editing events in the alternative splicing sites for OPRD1

Differntial gene expression between RNA A-to-I edited versus non-edited samples for OPRD1

Protein coding region RNA A-to-I editings for OPRD1

The effects of the RNA editing to the miRNA binding sites for OPRD1

The effects of the RNA editing to the stability of the RNA structures for OPRD1

Relation with ADAR for OPRD1

Relation with AD stages for OPRD1

RelatedDrugs for OPRD1

RelatedDiseases for OPRD1

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene