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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for CISD2

check button Gene summary
Gene informationGene symbol

CISD2

Gene ID

493856

Gene nameCDGSH iron sulfur domain 2
SynonymsERIS|Miner1|NAF-1|WFS2|ZCD2
Cytomap

4q24

Type of geneprotein-coding
DescriptionCDGSH iron-sulfur domain-containing protein 2endoplasmic reticulum intermembrane small proteinmitoNEET-related 1 proteinnutrient-deprivation autophagy factor-1zinc finger, CDGSH-type domain 2
Modification date20200313
UniProtAcc

Q8N5K1,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for CISD2

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1101204(102872143, +), ADediting_1101205(102872148, +), ADediting_1101206(102872186, +), ADediting_1101207(102872194, +), ADediting_1101208(102872253, +), ADediting_1101209(102873289, +), ADediting_1101210(102873290, +), ADediting_1101211(102873298, +), ADediting_1101212(102873372, +), ADediting_1101213(102873384, +), ADediting_1101214(102873389, +), ADediting_1101215(102873401, +), ADediting_1101216(102873411, +), ADediting_1101217(102873413, +), ADediting_1101218(102873419, +), ADediting_1101219(102873458, +), ADediting_1101220(102873484, +), ADediting_1101221(102873706, +), ADediting_1101222(102873870, +), ADediting_1101223(102873887, +), ADediting_1101224(102873926, +), ADediting_1101225(102873973, +), ADediting_1101226(102873974, +), ADediting_1101227(102873992, +), ADediting_1101228(102873997, +), ADediting_1101229(102874019, +), ADediting_1101230(102874032, +), ADediting_1101231(102874113, +), ADediting_1101232(102876494, +), ADediting_1101233(102876495, +), ADediting_1101234(102876509, +), ADediting_1101235(102876516, +), ADediting_1101236(102876517, +), ADediting_1101237(102876552, +), ADediting_1101238(102876570, +), ADediting_1101239(102876572, +), ADediting_1101240(102876577, +), ADediting_1101241(102876603, +), ADediting_1101242(102876643, +), ADediting_1101243(102876699, +), ADediting_1101244(102878167, +), ADediting_1101245(102878235, +), ADediting_1101246(102878236, +), ADediting_1101247(102878271, +), ADediting_1101248(102878311, +), ADediting_1101249(102878314, +), ADediting_1101250(102878397, +), ADediting_1101251(102879527, +), ADediting_1101252(102879528, +), ADediting_1101253(102879965, +), ADediting_1101254(102880012, +), ADediting_1101255(102880043, +), ADediting_1101256(102880082, +), ADediting_1101257(102880179, +), ADediting_1101258(102880196, +), ADediting_1101259(102880218, +), ADediting_1101260(102880760, +), ADediting_1101261(102880798, +), ADediting_1101262(102881930, +), ADediting_1101263(102881942, +), ADediting_1101264(102881963, +), ADediting_1101265(102881982, +), ADediting_1101266(102882071, +), ADediting_1101267(102882081, +), ADediting_1101268(102882148, +), ADediting_1101269(102882803, +), ADediting_1101270(102882808, +), ADediting_1101271(102882847, +), ADediting_1101272(102882876, +), ADediting_1101273(102882886, +), ADediting_1101274(102882957, +), ADediting_1101275(102882976, +), ADediting_1575916(102876705, +),

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RNA editing positional annotations for CISD2 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
ADediting_1101269chr4_102882803_+nonsynonymous SNVENST00000574446.1c.A136Gp.M46V...
ADediting_1101269chr4_102882803_+nonsynonymous SNVENST00000646632.1c.A115Gp.M39V...
ADediting_1101270chr4_102882808_+synonymous SNVENST00000574446.1c.A141Gp.A47A...
ADediting_1101270chr4_102882808_+synonymous SNVENST00000646632.1c.A120Gp.A40A...

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1101204chr4_102872143_+intronic
ADediting_1101205chr4_102872148_+intronic
ADediting_1101206chr4_102872186_+intronic
ADediting_1101207chr4_102872194_+intronic
ADediting_1101208chr4_102872253_+intronic
ADediting_1101209chr4_102873289_+intronic
ADediting_1101210chr4_102873290_+intronic
ADediting_1101211chr4_102873298_+intronic
ADediting_1101212chr4_102873372_+intronic
ADediting_1101213chr4_102873384_+intronic
ADediting_1101214chr4_102873389_+intronic
ADediting_1101215chr4_102873401_+intronic
ADediting_1101216chr4_102873411_+intronic
ADediting_1101217chr4_102873413_+intronic
ADediting_1101218chr4_102873419_+intronic
ADediting_1101219chr4_102873458_+intronic
ADediting_1101220chr4_102873484_+intronic
ADediting_1101221chr4_102873706_+intronic
ADediting_1101222chr4_102873870_+intronic
ADediting_1101223chr4_102873887_+intronic
ADediting_1101224chr4_102873926_+intronic
ADediting_1101225chr4_102873973_+intronic
ADediting_1101226chr4_102873974_+intronic
ADediting_1101227chr4_102873992_+intronic
ADediting_1101228chr4_102873997_+intronic
ADediting_1101229chr4_102874019_+intronic
ADediting_1101230chr4_102874032_+intronic
ADediting_1101231chr4_102874113_+intronic
ADediting_1101232chr4_102876494_+intronic
ADediting_1101233chr4_102876495_+intronic
ADediting_1101234chr4_102876509_+intronic
ADediting_1101235chr4_102876516_+intronic
ADediting_1101236chr4_102876517_+intronic
ADediting_1101237chr4_102876552_+intronic
ADediting_1101238chr4_102876570_+intronic
ADediting_1101239chr4_102876572_+intronic
ADediting_1101240chr4_102876577_+intronic
ADediting_1101241chr4_102876603_+intronic
ADediting_1101242chr4_102876643_+intronic
ADediting_1101243chr4_102876699_+intronic
ADediting_1101244chr4_102878167_+intronic
ADediting_1101245chr4_102878235_+intronic
ADediting_1101246chr4_102878236_+intronic
ADediting_1101247chr4_102878271_+intronic
ADediting_1101248chr4_102878311_+intronic
ADediting_1101249chr4_102878314_+intronic
ADediting_1101250chr4_102878397_+intronic
ADediting_1101251chr4_102879527_+intronic
ADediting_1101252chr4_102879528_+intronic
ADediting_1101253chr4_102879965_+intronic
ADediting_1101254chr4_102880012_+intronic
ADediting_1101255chr4_102880043_+intronic
ADediting_1101256chr4_102880082_+intronic
ADediting_1101257chr4_102880179_+intronic
ADediting_1101258chr4_102880196_+intronic
ADediting_1101259chr4_102880218_+intronic
ADediting_1101260chr4_102880760_+intronic
ADediting_1101261chr4_102880798_+intronic
ADediting_1101262chr4_102881930_+intronic
ADediting_1101263chr4_102881942_+intronic
ADediting_1101264chr4_102881963_+intronic
ADediting_1101265chr4_102881982_+intronic
ADediting_1101266chr4_102882071_+intronic
ADediting_1101267chr4_102882081_+intronic
ADediting_1101268chr4_102882148_+intronic
ADediting_1101269chr4_102882803_+exonic
ADediting_1101270chr4_102882808_+exonic
ADediting_1101271chr4_102882847_+UTR3
ADediting_1101272chr4_102882876_+intronic
ADediting_1101273chr4_102882886_+intronic
ADediting_1101274chr4_102882957_+intronic
ADediting_1101275chr4_102882976_+intronic
ADediting_1575916chr4_102876705_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1101204chr4_102872143_+SINEAluName=AluSx3
ADediting_1101205chr4_102872148_+SINEAluName=AluSx3
ADediting_1101206chr4_102872186_+SINEAluName=AluSx3
ADediting_1101207chr4_102872194_+SINEAluName=AluSx3
ADediting_1101208chr4_102872253_+SINEAluName=AluSx3
ADediting_1101209chr4_102873289_+SINEAluName=AluJb
ADediting_1101210chr4_102873290_+SINEAluName=AluJb
ADediting_1101211chr4_102873298_+SINEAluName=AluJb
ADediting_1101212chr4_102873372_+SINEAluName=AluJb
ADediting_1101213chr4_102873384_+SINEAluName=AluJb
ADediting_1101214chr4_102873389_+SINEAluName=AluJb
ADediting_1101215chr4_102873401_+SINEAluName=AluJb
ADediting_1101216chr4_102873411_+SINEAluName=AluJb
ADediting_1101217chr4_102873413_+SINEAluName=AluJb
ADediting_1101218chr4_102873419_+SINEAluName=AluJb
ADediting_1101219chr4_102873458_+SINEAluName=AluJb
ADediting_1101220chr4_102873484_+SINEAluName=AluJb
ADediting_1101221chr4_102873706_+SINEAluName=FLAM_A
ADediting_1101222chr4_102873870_+SINEAluName=AluSz
ADediting_1101223chr4_102873887_+SINEAluName=AluSz
ADediting_1101224chr4_102873926_+SINEAluName=AluSz
ADediting_1101225chr4_102873973_+SINEAluName=AluSz
ADediting_1101226chr4_102873974_+SINEAluName=AluSz
ADediting_1101227chr4_102873992_+SINEAluName=AluSz
ADediting_1101228chr4_102873997_+SINEAluName=AluSz
ADediting_1101229chr4_102874019_+SINEAluName=AluSz
ADediting_1101230chr4_102874032_+SINEAluName=AluSz
ADediting_1101231chr4_102874113_+SINEAluName=AluSz
ADediting_1101232chr4_102876494_+SINEAluName=AluSc
ADediting_1101233chr4_102876495_+SINEAluName=AluSc
ADediting_1101234chr4_102876509_+SINEAluName=AluSc
ADediting_1101235chr4_102876516_+SINEAluName=AluSc
ADediting_1101236chr4_102876517_+SINEAluName=AluSc
ADediting_1101237chr4_102876552_+SINEAluName=AluSc
ADediting_1101238chr4_102876570_+SINEAluName=AluSc
ADediting_1101239chr4_102876572_+SINEAluName=AluSc
ADediting_1101240chr4_102876577_+SINEAluName=AluSc
ADediting_1101241chr4_102876603_+SINEAluName=AluSc
ADediting_1101242chr4_102876643_+SINEAluName=AluSc
ADediting_1101243chr4_102876699_+SINEAluName=AluSc
ADediting_1101244chr4_102878167_+SINEAluName=AluSc
ADediting_1101245chr4_102878235_+SINEAluName=AluSc
ADediting_1101246chr4_102878236_+SINEAluName=AluSc
ADediting_1101247chr4_102878271_+SINEAluName=AluSc
ADediting_1101248chr4_102878311_+SINEAluName=AluSc
ADediting_1101249chr4_102878314_+SINEAluName=AluSc
ADediting_1101250chr4_102878397_+SINEAluName=AluSc
ADediting_1101251chr4_102879527_+SINEAluName=AluSx1
ADediting_1101252chr4_102879528_+SINEAluName=AluSx1
ADediting_1101253chr4_102879965_+SINEAluName=AluSz
ADediting_1101254chr4_102880012_+SINEAluName=AluSz
ADediting_1101255chr4_102880043_+SINEAluName=AluSz
ADediting_1101256chr4_102880082_+SINEAluName=AluSz
ADediting_1101257chr4_102880179_+SINEAluName=AluSz
ADediting_1101258chr4_102880196_+SINEAluName=AluSz
ADediting_1101259chr4_102880218_+SINEAluName=AluSz
ADediting_1101260chr4_102880760_+SINEAluName=AluSx
ADediting_1101261chr4_102880798_+SINEAluName=AluSx
ADediting_1101262chr4_102881930_+SINEAluName=AluSq
ADediting_1101263chr4_102881942_+SINEAluName=AluSq
ADediting_1101264chr4_102881963_+SINEAluName=AluSq
ADediting_1101265chr4_102881982_+SINEAluName=AluSq
ADediting_1101266chr4_102882071_+SINEAluName=AluSq
ADediting_1101267chr4_102882081_+SINEAluName=AluSq
ADediting_1101268chr4_102882148_+SINEAluName=AluSq
ADediting_1101269chr4_102882803_+SINEAluName=AluSx3
ADediting_1101270chr4_102882808_+SINEAluName=AluSx3
ADediting_1101271chr4_102882847_+SINEAluName=AluSx3
ADediting_1101272chr4_102882876_+SINEAluName=AluSx3
ADediting_1101273chr4_102882886_+SINEAluName=AluSx3
ADediting_1101274chr4_102882957_+SINEAluName=AluSx3
ADediting_1101275chr4_102882976_+SINEAluName=AluSx3
ADediting_1575916chr4_102876705_+SINEAluName=AluSc

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RNA A-to-I editing events in the alternative splicing sites for CISD2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESADediting_1101272chr4_102882876_+102882871:1028828795ss3iCAGGTAGCT6.52CAGGTGGCT2.97
ESADediting_1101272chr4_102882876_+102882871:1028828795ss3iCAGGTAGCT6.52CAGGTGGCT2.97

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CISD2

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
boxplot
boxplot
boxplot
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for CISD2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
all structure


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The effects of the RNA editing to the miRNA binding sites for CISD2


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-5688chr41028919891028919957mer-m8102891975102891996153-13.09
ADediting_1337758chr7_5495892_-ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-589-5pchr41028894661028894738mer-1a102889452102889473150-21.48
ADediting_1535951chr14_100874558_+ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-337-3pchr41028894861028894927mer-m8102889472102889493148-14.04
ADediting_1535951chr14_100874558_+ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-337-3pchr41028902571028902648mer-1a102890243102890264146-10.41
ADediting_286380chr11_79422188_-ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-5579-3pchr41028902631028902697mer-1a102890256102890278146-15.22
ADediting_286380chr11_79422188_-ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-5579-3pchr41028902711028902777mer-m8102890256102890278146-15.22
ADediting_843620chr2_207754818_+ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-4775chr41028876451028876517mer-m8102887630102887652156-8.77
ADediting_843620chr2_207754818_+ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-4775chr41028918261028918327mer-m8102891812102891833159-9.92
ADediting_843620chr2_207754818_+ENSG00000145354.12ENST00000503643.1CISD2-202hsa-miR-4775chr41028876451028876517mer-m8102887630102887652156-8.77
ADediting_98288chr1_32086990_+ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-5585-3pchr41028900281028900347mer-m8102890010102890035143-18.47
ADediting_98289chr1_32086992_+ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-5585-3pchr41028916741028916818mer-1a102891661102891681148-15.43

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-5688chr41028877031028877097mer-m8102887689102887710155-10.6
ADediting_1097295chr3_85385762_+ENSG00000145354.12ENST00000503643.1CISD2-202hsa-miR-5688chr41028877031028877097mer-m8102887689102887710155-10.6
ADediting_1535951chr14_100874558_+ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-337-3pchr41028914221028914287mer-m8102891408102891429153-9.28
ADediting_1535953chr14_101045971_+ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-381-3pchr41028877391028877457mer-m8102887725102887746144-12.96
ADediting_1535953chr14_101045971_+ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-381-3pchr41028890201028890267mer-m8102889006102889027147-12.22
ADediting_1535953chr14_101045971_+ENSG00000145354.12ENST00000503643.1CISD2-202hsa-miR-381-3pchr41028877391028877457mer-m8102887725102887746144-12.96
ADediting_1535954chr14_101045974_+ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-381-3pchr41028877391028877457mer-m8102887725102887746144-12.96
ADediting_1535954chr14_101045974_+ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-381-3pchr41028890201028890267mer-m8102889006102889027147-12.22
ADediting_1535954chr14_101045974_+ENSG00000145354.12ENST00000503643.1CISD2-202hsa-miR-381-3pchr41028877391028877457mer-m8102887725102887746144-12.96
ADediting_1556067chr19_40282625_-ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-641chr41028899371028899437mer-m8102889918102889944153-15.73
ADediting_1631458chr19_40282624_-ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-641chr41028899371028899437mer-m8102889918102889944153-15.73
ADediting_98288chr1_32086990_+ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-5585-3pchr41028875661028875727mer-m8102887550102887573146-17.52
ADediting_98288chr1_32086990_+ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-5585-3pchr41028915221028915287mer-1a102891507102891528146-14.78
ADediting_98288chr1_32086990_+ENSG00000145354.12ENST00000503643.1CISD2-202hsa-miR-5585-3pchr41028875661028875727mer-m8102887550102887573146-17.52
ADediting_98289chr1_32086992_+ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-5585-3pchr41028875661028875727mer-m8102887550102887573146-17.52
ADediting_98289chr1_32086992_+ENSG00000145354.12ENST00000273986.10CISD2-201hsa-miR-5585-3pchr41028915221028915287mer-1a102891507102891528146-14.78
ADediting_98289chr1_32086992_+ENSG00000145354.12ENST00000503643.1CISD2-202hsa-miR-5585-3pchr41028875661028875727mer-m8102887550102887573146-17.52

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CISD2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for CISD2

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_1101210chr4_102873290_+0.08881643879166140.09681255833224270.677209259258857-0.02373534819184331.64908402854074e-100.352674536703495
DLPFCADediting_1101212chr4_102873372_+0.05979017887841870.1070346788438180.777275167927235-0.01613015111616253.98457961404825e-100.345628000957733
DLPFCADediting_1101217chr4_102873413_+0.1635222370908450.07933111768581290.610803710589378-0.02901621695032152.69541424256028e-110.366618934819616
DLPFCADediting_1101218chr4_102873419_+0.1582242023077750.0803382988156080.8644235734481810.009736819708161693.13999182010203e-090.328415159073464

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC5.75025676591319e-600.7615579483515011.4025810757457e-460.6979810560584090.1259050320907190.087110393795182
AC3.21156963592096e-660.8347780305866995.47798139002563e-420.7246538864967535.70771353310752e-160.482310388363647
PCC8.17475498308347e-340.7357044647269629.29350648714316e-370.7568966556503870.09226278380979560.122164819865151
CER1.65294313193349e-190.6518550797980963.20862788592823e-190.6479069355874090.1297877306030410.124253867989443
TCX7.58631934558304e-350.8013737898915671.60351036444187e-170.6233762538122640.1734702230290280.111722764683122
FP3.76045693943556e-050.3037453169157224.45161504955283e-150.5436436706015970.258472405593666-0.0851437203349566
IFG0.0002174393845548830.674511687008150.002117782306214020.5852456796268740.506404302418119-0.139373848044883
PG9.3951008391923e-380.7700030419891033.10207314929665e-220.6331934965197360.301945212008901-0.0760929454616074
STG4.25539241374649e-080.5551106758215022.3602043968332e-110.649377191681180.0243473853743711-0.245574628849473

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Relation with AD stages for CISD2

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.

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RelatedDrugs for CISD2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CISD2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
CISD2C0043207Wolfram Syndrome6CLINGEN;ORPHANET
CISD2C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
CISD2C1858028WOLFRAM SYNDROME 21CTD_human