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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for HCG11

check button Gene summary
Gene informationGene symbol

HCG11

Gene ID

493812

Gene nameHLA complex group 11
SynonymsCTA-14H9.3|bK14H9.3
Cytomap

6p22.2

Type of genencRNA
DescriptionHLA complex group 11 (non-protein coding)
Modification date20200313
UniProtAcc

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for HCG11

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1253581(26525384, +), ADediting_1253582(26525385, +), ADediting_1253583(26525415, +), ADediting_1253584(26525424, +), ADediting_1253585(26525429, +), ADediting_1253586(26525451, +), ADediting_1253587(26525452, +), ADediting_1253588(26525491, +), ADediting_1253589(26525527, +), ADediting_1253590(26525544, +), ADediting_1253591(26525582, +), ADediting_1253592(26525583, +), ADediting_1253593(26526353, +),

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RNA editing positional annotations for HCG11 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1253581chr6_26525384_+ncRNA_exonic
ADediting_1253582chr6_26525385_+ncRNA_exonic
ADediting_1253583chr6_26525415_+ncRNA_exonic
ADediting_1253584chr6_26525424_+ncRNA_exonic
ADediting_1253585chr6_26525429_+ncRNA_exonic
ADediting_1253586chr6_26525451_+ncRNA_exonic
ADediting_1253587chr6_26525452_+ncRNA_exonic
ADediting_1253588chr6_26525491_+ncRNA_exonic
ADediting_1253589chr6_26525527_+ncRNA_exonic
ADediting_1253590chr6_26525544_+ncRNA_exonic
ADediting_1253591chr6_26525582_+ncRNA_exonic
ADediting_1253592chr6_26525583_+ncRNA_exonic
ADediting_1253593chr6_26526353_+ncRNA_exonic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1253581chr6_26525384_+SINEAluName=AluSc
ADediting_1253582chr6_26525385_+SINEAluName=AluSc
ADediting_1253583chr6_26525415_+SINEAluName=AluSc
ADediting_1253584chr6_26525424_+SINEAluName=AluSc
ADediting_1253585chr6_26525429_+SINEAluName=AluSc
ADediting_1253586chr6_26525451_+SINEAluName=AluSc
ADediting_1253587chr6_26525452_+SINEAluName=AluSc
ADediting_1253588chr6_26525491_+SINEAluName=AluSc
ADediting_1253589chr6_26525527_+SINEAluName=AluSc
ADediting_1253590chr6_26525544_+SINEAluName=AluSc
ADediting_1253591chr6_26525582_+SINEAluName=AluSc
ADediting_1253592chr6_26525583_+SINEAluName=AluSc
ADediting_1253593chr6_26526353_+SINEAluName=AluSc

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RNA A-to-I editing events in the alternative splicing sites for HCG11

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for HCG11

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for HCG11

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for HCG11

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1253581chr6_26525384_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-513a-5pchr626525379265253857mer-m82652536926525386148-20.07
ADediting_1253582chr6_26525385_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-4759chr626525383265253897mer-m82652537026525390145-14.41
ADediting_1253584chr6_26525424_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-6790-3pchr626525421265254288mer-1a2652540826525428147-20.4
ADediting_1253585chr6_26525429_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-4732-3pchr626525425265254317mer-m82652541426525432151-20.02
ADediting_1253587chr6_26525452_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-3190-5pchr626525446265254527mer-m82652543426525453151-17.15
ADediting_1253589chr6_26525527_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-1207-3pchr626525521265255277mer-m82652551026525528145-13.53
ADediting_1253589chr6_26525527_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-646chr626525523265255297mer-m82652551126525530148-21.05
ADediting_1253591chr6_26525582_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-1304-3pchr626525578265255847mer-m82652556426525585167-27.41
ADediting_1253591chr6_26525582_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-4284chr626525580265255867mer-m82652557026525587151-15.7
ADediting_1253592chr6_26525583_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-24-1-5pchr626525579265255857mer-m82652556426525586154-20.83
ADediting_1253592chr6_26525583_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-24-2-5pchr626525579265255857mer-m82652556426525586148-17.66
ADediting_1253593chr6_26526353_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-4707-3pchr626526350265263578mer-1a2652633626526357162-27.57

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1253581chr6_26525384_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-10399-5pchr626525380265253867mer-m82652536626525387148-11.2
ADediting_1253581chr6_26525384_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-6504-3pchr626525380265253867mer-m82652536626525387153-14.35
ADediting_1253582chr6_26525385_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-10399-5pchr626525380265253867mer-m82652536626525387148-11.2
ADediting_1253582chr6_26525385_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-6504-3pchr626525380265253867mer-m82652536626525387153-14.35
ADediting_1253585chr6_26525429_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-10397-5pchr626525425265254317mer-m82652541126525432150-19.55
ADediting_1253585chr6_26525429_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-4780chr626525426265254338mer-1a2652540826525433154-21.29
ADediting_1253585chr6_26525429_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-623chr626525427265254337mer-m82652541226525434140-17.32
ADediting_1253585chr6_26525429_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-6866-3pchr626525428265254347mer-m82652541326525435155-17.25
ADediting_1253586chr6_26525451_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-4781-3pchr626525449265254557mer-m82652543826525456144-12.49
ADediting_1253586chr6_26525451_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-548schr626525445265254528mer-1a2652543026525452142-11.05
ADediting_1253587chr6_26525452_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-4716-5pchr626525451265254577mer-m82652543726525458140-10.98
ADediting_1253587chr6_26525452_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-4781-3pchr626525449265254557mer-m82652543826525456144-12.49
ADediting_1253588chr6_26525491_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-4735-5pchr626525486265254927mer-m82652547226525493140-4.7
ADediting_1253590chr6_26525544_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-1976chr626525542265255498mer-1a2652552926525549149-24.39
ADediting_1253590chr6_26525544_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-6747-3pchr626525540265255478mer-1a2652552526525547149-23.68
ADediting_1253593chr6_26526353_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-6747-3pchr626526349265263557mer-m82652633526526356150-22.22

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337757chr7_5495852_-ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-589-3pchr626523745265237517mer-m82652372926523752154-16.08
ADediting_1631458chr19_40282624_-ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-641chr626525991265259988mer-1a2652597626525998151-15.04
ADediting_291761chr11_93733708_-ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-1304-3pchr626523096265231027mer-m82652308226523103157-20.09
ADediting_843620chr2_207754818_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-4775chr626527174265271807mer-m82652716226527181148-8.77
ADediting_843620chr2_207754818_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-4775chr626527390265273967mer-m82652737626527397168-8.1

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_107020chr1_37500952_-ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-5581-3pchr626522125265221317mer-m82652211326522132148-21.27
ADediting_1097295chr3_85385762_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-5688chr626522701265227077mer-m82652268726522708140-8.45
ADediting_1535951chr14_100874558_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-337-3pchr626526832265268398mer-1a2652681726526839146-11.45
ADediting_1556067chr19_40282625_-ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-641chr626522636265226427mer-m82652262126522643143-8.67
ADediting_1631458chr19_40282624_-ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-641chr626522636265226427mer-m82652262126522643143-8.67
ADediting_496066chr15_66496985_-ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-4512chr626521778265217847mer-m82652176826521785143-22.51
ADediting_527135chr16_24203190_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-1273h-3pchr626524948265249547mer-m82652493426524955140-11.56
ADediting_843620chr2_207754818_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-4775chr626522917265229237mer-m82652290026522924151-14.33
ADediting_98288chr1_32086990_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-5585-3pchr626525274265252807mer-1a2652526026525280141-10.23
ADediting_98288chr1_32086990_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-5585-3pchr626525788265257947mer-m82652577526525795152-11.09
ADediting_98289chr1_32086992_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-5585-3pchr626525274265252807mer-1a2652526026525280141-10.23
ADediting_98289chr1_32086992_+ENSG00000228223.3ENST00000411553.3HCG11-201hsa-miR-5585-3pchr626525788265257947mer-m82652577526525795152-11.09

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for HCG11

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000411553.3lncRNASoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_1253581ENST00000411553.3chr6_26525384_+3676-1769.00-1768.30-1786.50
ADediting_1253582ENST00000411553.3chr6_26525385_+3677-1767.00-1768.30-1786.50
ADediting_1253583ENST00000411553.3chr6_26525415_+3707-1770.50-1768.30-1786.50
ADediting_1253584ENST00000411553.3chr6_26525424_+3716-1770.60-1768.30-1786.50
ADediting_1253585ENST00000411553.3chr6_26525429_+3721-1768.40-1768.30-1786.50
ADediting_1253586ENST00000411553.3chr6_26525451_+3743-1771.40-1768.30-1786.50
ADediting_1253587ENST00000411553.3chr6_26525452_+3744-1768.00-1768.30-1786.50
ADediting_1253588ENST00000411553.3chr6_26525491_+3783-1768.00-1768.30-1786.50
ADediting_1253589ENST00000411553.3chr6_26525527_+3819-1770.00-1768.30-1786.50
ADediting_1253590ENST00000411553.3chr6_26525544_+3836-1772.40-1768.30-1786.50
ADediting_1253591ENST00000411553.3chr6_26525582_+3874-1773.20-1768.30-1786.50
ADediting_1253592ENST00000411553.3chr6_26525583_+3875-1769.50-1768.30-1786.50
ADediting_1253593ENST00000411553.3chr6_26526353_+4645-1769.50-1768.30-1786.50

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Relation with ADAR for HCG11

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_1253591chr6_26525582_+0.02497849001316960.1273177706533460.7021172652999310.02180800790448335.59019455836656e-100.342876366227632

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC1.02730438892741e-250.548186350397632.15464993592434e-110.3682969254939995.57785782186392e-390.652468692855675
AC5.51738914253248e-610.8160673739011646.63911013188529e-320.6540657235644239.68300038116971e-290.627199191199945
PCC8.67206378826589e-310.7115718626896119.50218755535686e-270.6749580915952562.23440535383327e-070.364161107518905
CER2.94199828571558e-310.7746677454161136.06631329182779e-120.5237940591509640.0174381802808170.193884984447802
TCX6.57996936651383e-310.7718523131459794.66644221960145e-160.6003484212781670.04522832017203170.163769828328727
FP4.35623946220845e-180.5901726901878033.15412815148779e-200.61924894847060.0001725750571696710.277923436332377
IFG2.72461175958537e-050.7362259073958565.18642350802804e-060.7758608539903590.4853059309718480.146294879856046
PG1.33762868039844e-420.7995392494064011.62560770289895e-210.624610809986360.5561417479950920.0434293231018289
STG3.72675312837643e-090.5892012828148418.16141035372148e-090.5786460111996590.04076663317417250.223739607945003

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Relation with AD stages for HCG11

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
TCX4.01370560661183e-070.468793369572712

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RelatedDrugs for HCG11

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HCG11

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource