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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for NOVA1 |
 Gene summary |
| Gene information | Gene symbol | NOVA1 | Gene ID | 4857 |
| Gene name | NOVA alternative splicing regulator 1 | |
| Synonyms | Nova-1 | |
| Cytomap | 14q12 | |
| Type of gene | protein-coding | |
| Description | RNA-binding protein Nova-1neuro-oncological ventral antigen 1onconeural ventral antigen 1paraneoplastic Ri antigenventral neuron-specific protein 1 | |
| Modification date | 20200327 | |
| UniProtAcc | P51513, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for NOVA1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_421887(26448309, -), ADediting_421888(26448324, -), ADediting_421889(26451479, -), ADediting_421890(26451488, -), ADediting_421891(26451600, -), ADediting_421892(26453348, -), ADediting_421893(26458555, -), ADediting_421894(26458556, -), ADediting_421895(26458579, -), ADediting_421896(26458585, -), ADediting_421897(26458586, -), ADediting_421898(26458588, -), ADediting_421899(26458595, -), ADediting_421900(26458596, -), ADediting_421901(26460132, -), ADediting_421902(26460140, -), ADediting_421903(26461666, -), ADediting_421904(26461694, -), ADediting_421905(26461712, -), ADediting_421906(26461812, -), ADediting_421907(26461864, -), ADediting_421908(26461901, -), ADediting_421909(26461914, -), ADediting_421910(26461927, -), ADediting_421911(26465205, -), ADediting_421912(26465237, -), ADediting_421913(26465271, -), ADediting_421914(26465286, -), ADediting_421915(26465398, -), ADediting_421916(26469726, -), ADediting_421917(26469880, -), ADediting_421918(26471040, -), ADediting_421919(26471164, -), ADediting_421920(26489724, -), ADediting_421921(26489727, -), ADediting_421922(26489830, -), ADediting_421923(26490752, -), ADediting_421924(26492835, -), ADediting_421925(26492843, -), ADediting_421926(26492889, -), ADediting_421927(26511511, -), ADediting_421928(26511729, -), ADediting_421929(26523889, -), ADediting_421930(26524026, -), ADediting_421931(26529242, -), ADediting_421932(26529275, -), ADediting_421933(26529320, -), ADediting_421934(26529357, -), ADediting_421935(26529365, -), ADediting_421936(26535768, -), ADediting_421937(26549095, -), ADediting_421938(26567388, -), ADediting_421939(26570164, -), ADediting_421940(26570175, -), ADediting_421941(26574861, -), ADediting_1536466(26451496, -), ADediting_1536467(26453352, -), ADediting_1536468(26465204, -), ADediting_1536469(26465384, -), ADediting_1536470(26469828, -), ADediting_1618231(26451398, -), ADediting_1618232(26458591, -), ADediting_1618233(26461746, -), ADediting_1618234(26465251, -), ADediting_1618235(26570190, -), |
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RNA editing positional annotations for NOVA1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_421887 | chr14_26448309_- | nonsynonymous SNV | ENST00000539517.7 | c.A1174G | p.T392A | 0.2 | 0.034 | 0.12 |
| ADediting_421887 | chr14_26448309_- | nonsynonymous SNV | ENST00000465357.6 | c.A1102G | p.T368A | 0.2 | 0.034 | 0.12 |
| ADediting_421888 | chr14_26448324_- | nonsynonymous SNV | ENST00000539517.7 | c.A1159G | p.S387G | 0.25 | 0.001 | -0.37 |
| ADediting_421888 | chr14_26448324_- | nonsynonymous SNV | ENST00000465357.6 | c.A1087G | p.S363G | 0.25 | 0.001 | -0.37 |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_421887 | chr14_26448309_- | exonic |
| ADediting_421888 | chr14_26448324_- | exonic |
| ADediting_421889 | chr14_26451479_- | intronic |
| ADediting_421890 | chr14_26451488_- | intronic |
| ADediting_421891 | chr14_26451600_- | intronic |
| ADediting_421892 | chr14_26453348_- | intronic |
| ADediting_421893 | chr14_26458555_- | intronic |
| ADediting_421894 | chr14_26458556_- | intronic |
| ADediting_421895 | chr14_26458579_- | intronic |
| ADediting_421896 | chr14_26458585_- | intronic |
| ADediting_421897 | chr14_26458586_- | intronic |
| ADediting_421898 | chr14_26458588_- | intronic |
| ADediting_421899 | chr14_26458595_- | intronic |
| ADediting_421900 | chr14_26458596_- | intronic |
| ADediting_421901 | chr14_26460132_- | intronic |
| ADediting_421902 | chr14_26460140_- | intronic |
| ADediting_421903 | chr14_26461666_- | intronic |
| ADediting_421904 | chr14_26461694_- | intronic |
| ADediting_421905 | chr14_26461712_- | intronic |
| ADediting_421906 | chr14_26461812_- | intronic |
| ADediting_421907 | chr14_26461864_- | intronic |
| ADediting_421908 | chr14_26461901_- | intronic |
| ADediting_421909 | chr14_26461914_- | intronic |
| ADediting_421910 | chr14_26461927_- | intronic |
| ADediting_421911 | chr14_26465205_- | intronic |
| ADediting_421912 | chr14_26465237_- | intronic |
| ADediting_421913 | chr14_26465271_- | intronic |
| ADediting_421914 | chr14_26465286_- | intronic |
| ADediting_421915 | chr14_26465398_- | intronic |
| ADediting_421916 | chr14_26469726_- | intronic |
| ADediting_421917 | chr14_26469880_- | intronic |
| ADediting_421918 | chr14_26471040_- | intronic |
| ADediting_421919 | chr14_26471164_- | intronic |
| ADediting_421920 | chr14_26489724_- | intronic |
| ADediting_421921 | chr14_26489727_- | intronic |
| ADediting_421922 | chr14_26489830_- | intronic |
| ADediting_421923 | chr14_26490752_- | intronic |
| ADediting_421924 | chr14_26492835_- | intronic |
| ADediting_421925 | chr14_26492843_- | intronic |
| ADediting_421926 | chr14_26492889_- | intronic |
| ADediting_421927 | chr14_26511511_- | intronic |
| ADediting_421928 | chr14_26511729_- | intronic |
| ADediting_421929 | chr14_26523889_- | intronic |
| ADediting_421930 | chr14_26524026_- | intronic |
| ADediting_421931 | chr14_26529242_- | intronic |
| ADediting_421932 | chr14_26529275_- | intronic |
| ADediting_421933 | chr14_26529320_- | intronic |
| ADediting_421934 | chr14_26529357_- | intronic |
| ADediting_421935 | chr14_26529365_- | intronic |
| ADediting_421936 | chr14_26535768_- | intronic |
| ADediting_421937 | chr14_26549095_- | intronic |
| ADediting_421938 | chr14_26567388_- | intronic |
| ADediting_421939 | chr14_26570164_- | intronic |
| ADediting_421940 | chr14_26570175_- | intronic |
| ADediting_421941 | chr14_26574861_- | intronic |
| ADediting_1536466 | chr14_26451496_- | intronic |
| ADediting_1536467 | chr14_26453352_- | intronic |
| ADediting_1536468 | chr14_26465204_- | intronic |
| ADediting_1536469 | chr14_26465384_- | intronic |
| ADediting_1536470 | chr14_26469828_- | intronic |
| ADediting_1618231 | chr14_26451398_- | intronic |
| ADediting_1618232 | chr14_26458591_- | intronic |
| ADediting_1618233 | chr14_26461746_- | intronic |
| ADediting_1618234 | chr14_26465251_- | intronic |
| ADediting_1618235 | chr14_26570190_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_421889 | chr14_26451479_- | SINE | Alu | Name=AluSx |
| ADediting_421890 | chr14_26451488_- | SINE | Alu | Name=AluSx |
| ADediting_421891 | chr14_26451600_- | SINE | Alu | Name=AluSx |
| ADediting_421892 | chr14_26453348_- | SINE | Alu | Name=FRAM |
| ADediting_421893 | chr14_26458555_- | LINE | L1 | Name=L1PA16 |
| ADediting_421894 | chr14_26458556_- | LINE | L1 | Name=L1PA16 |
| ADediting_421895 | chr14_26458579_- | LINE | L1 | Name=L1PA16 |
| ADediting_421896 | chr14_26458585_- | LINE | L1 | Name=L1PA16 |
| ADediting_421897 | chr14_26458586_- | LINE | L1 | Name=L1PA16 |
| ADediting_421898 | chr14_26458588_- | LINE | L1 | Name=L1PA16 |
| ADediting_421899 | chr14_26458595_- | LINE | L1 | Name=L1PA16 |
| ADediting_421900 | chr14_26458596_- | LINE | L1 | Name=L1PA16 |
| ADediting_421901 | chr14_26460132_- | LINE | L1 | Name=L1PA17 |
| ADediting_421902 | chr14_26460140_- | LINE | L1 | Name=L1PA17 |
| ADediting_421903 | chr14_26461666_- | SINE | Alu | Name=AluSp |
| ADediting_421904 | chr14_26461694_- | SINE | Alu | Name=AluSp |
| ADediting_421905 | chr14_26461712_- | SINE | Alu | Name=AluSp |
| ADediting_421906 | chr14_26461812_- | SINE | Alu | Name=AluSp |
| ADediting_421907 | chr14_26461864_- | SINE | Alu | Name=AluSp |
| ADediting_421908 | chr14_26461901_- | SINE | Alu | Name=AluSp |
| ADediting_421909 | chr14_26461914_- | SINE | Alu | Name=AluSp |
| ADediting_421910 | chr14_26461927_- | SINE | Alu | Name=AluSp |
| ADediting_421911 | chr14_26465205_- | SINE | Alu | Name=AluSz |
| ADediting_421912 | chr14_26465237_- | SINE | Alu | Name=AluSz |
| ADediting_421913 | chr14_26465271_- | SINE | Alu | Name=AluSz |
| ADediting_421914 | chr14_26465286_- | SINE | Alu | Name=AluSz |
| ADediting_421915 | chr14_26465398_- | SINE | Alu | Name=AluSz |
| ADediting_421916 | chr14_26469726_- | SINE | Alu | Name=AluJr |
| ADediting_421917 | chr14_26469880_- | SINE | Alu | Name=AluJr |
| ADediting_421920 | chr14_26489724_- | SINE | Alu | Name=AluSx |
| ADediting_421921 | chr14_26489727_- | SINE | Alu | Name=AluSx |
| ADediting_421922 | chr14_26489830_- | SINE | Alu | Name=AluSx |
| ADediting_421923 | chr14_26490752_- | SINE | Alu | Name=AluJr |
| ADediting_421924 | chr14_26492835_- | SINE | Alu | Name=AluSz |
| ADediting_421925 | chr14_26492843_- | SINE | Alu | Name=AluSz |
| ADediting_421926 | chr14_26492889_- | SINE | Alu | Name=AluSz |
| ADediting_421927 | chr14_26511511_- | SINE | Alu | Name=AluSc |
| ADediting_421928 | chr14_26511729_- | SINE | Alu | Name=AluSc |
| ADediting_421929 | chr14_26523889_- | SINE | Alu | Name=AluY |
| ADediting_421930 | chr14_26524026_- | SINE | Alu | Name=AluY |
| ADediting_421931 | chr14_26529242_- | SINE | Alu | Name=AluSx1 |
| ADediting_421932 | chr14_26529275_- | SINE | Alu | Name=AluSx1 |
| ADediting_421933 | chr14_26529320_- | SINE | Alu | Name=AluSx1 |
| ADediting_421934 | chr14_26529357_- | SINE | Alu | Name=AluSx1 |
| ADediting_421935 | chr14_26529365_- | SINE | Alu | Name=AluSx1 |
| ADediting_421936 | chr14_26535768_- | SINE | Alu | Name=AluY |
| ADediting_421937 | chr14_26549095_- | SINE | Alu | Name=AluJr |
| ADediting_421938 | chr14_26567388_- | SINE | Alu | Name=AluJo |
| ADediting_421939 | chr14_26570164_- | SINE | Alu | Name=AluSx1 |
| ADediting_421940 | chr14_26570175_- | SINE | Alu | Name=AluSx1 |
| ADediting_421941 | chr14_26574861_- | SINE | Alu | Name=AluJr4 |
| ADediting_1536466 | chr14_26451496_- | SINE | Alu | Name=AluSx |
| ADediting_1536467 | chr14_26453352_- | SINE | Alu | Name=FRAM |
| ADediting_1536468 | chr14_26465204_- | SINE | Alu | Name=AluSz |
| ADediting_1536469 | chr14_26465384_- | SINE | Alu | Name=AluSz |
| ADediting_1536470 | chr14_26469828_- | SINE | Alu | Name=AluJr |
| ADediting_1618231 | chr14_26451398_- | SINE | Alu | Name=AluSx |
| ADediting_1618232 | chr14_26458591_- | LINE | L1 | Name=L1PA16 |
| ADediting_1618233 | chr14_26461746_- | SINE | Alu | Name=AluSp |
| ADediting_1618234 | chr14_26465251_- | SINE | Alu | Name=AluSz |
| ADediting_1618235 | chr14_26570190_- | SINE | Alu | Name=AluSx1 |
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RNA A-to-I editing events in the alternative splicing sites for NOVA1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NOVA1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |