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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for NOVA1 |
 Gene summary |
| Gene information | Gene symbol | NOVA1 | Gene ID | 4857 |
| Gene name | NOVA alternative splicing regulator 1 | |
| Synonyms | Nova-1 | |
| Cytomap | 14q12 | |
| Type of gene | protein-coding | |
| Description | RNA-binding protein Nova-1neuro-oncological ventral antigen 1onconeural ventral antigen 1paraneoplastic Ri antigenventral neuron-specific protein 1 | |
| Modification date | 20200327 | |
| UniProtAcc | P51513, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for NOVA1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_421887(26448309, -), ADediting_421888(26448324, -), ADediting_421889(26451479, -), ADediting_421890(26451488, -), ADediting_421891(26451600, -), ADediting_421892(26453348, -), ADediting_421893(26458555, -), ADediting_421894(26458556, -), ADediting_421895(26458579, -), ADediting_421896(26458585, -), ADediting_421897(26458586, -), ADediting_421898(26458588, -), ADediting_421899(26458595, -), ADediting_421900(26458596, -), ADediting_421901(26460132, -), ADediting_421902(26460140, -), ADediting_421903(26461666, -), ADediting_421904(26461694, -), ADediting_421905(26461712, -), ADediting_421906(26461812, -), ADediting_421907(26461864, -), ADediting_421908(26461901, -), ADediting_421909(26461914, -), ADediting_421910(26461927, -), ADediting_421911(26465205, -), ADediting_421912(26465237, -), ADediting_421913(26465271, -), ADediting_421914(26465286, -), ADediting_421915(26465398, -), ADediting_421916(26469726, -), ADediting_421917(26469880, -), ADediting_421918(26471040, -), ADediting_421919(26471164, -), ADediting_421920(26489724, -), ADediting_421921(26489727, -), ADediting_421922(26489830, -), ADediting_421923(26490752, -), ADediting_421924(26492835, -), ADediting_421925(26492843, -), ADediting_421926(26492889, -), ADediting_421927(26511511, -), ADediting_421928(26511729, -), ADediting_421929(26523889, -), ADediting_421930(26524026, -), ADediting_421931(26529242, -), ADediting_421932(26529275, -), ADediting_421933(26529320, -), ADediting_421934(26529357, -), ADediting_421935(26529365, -), ADediting_421936(26535768, -), ADediting_421937(26549095, -), ADediting_421938(26567388, -), ADediting_421939(26570164, -), ADediting_421940(26570175, -), ADediting_421941(26574861, -), ADediting_1536466(26451496, -), ADediting_1536467(26453352, -), ADediting_1536468(26465204, -), ADediting_1536469(26465384, -), ADediting_1536470(26469828, -), ADediting_1618231(26451398, -), ADediting_1618232(26458591, -), ADediting_1618233(26461746, -), ADediting_1618234(26465251, -), ADediting_1618235(26570190, -), |
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RNA editing positional annotations for NOVA1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_421887 | chr14_26448309_- | nonsynonymous SNV | ENST00000539517.7 | c.A1174G | p.T392A | 0.2 | 0.034 | 0.12 |
| ADediting_421887 | chr14_26448309_- | nonsynonymous SNV | ENST00000465357.6 | c.A1102G | p.T368A | 0.2 | 0.034 | 0.12 |
| ADediting_421888 | chr14_26448324_- | nonsynonymous SNV | ENST00000539517.7 | c.A1159G | p.S387G | 0.25 | 0.001 | -0.37 |
| ADediting_421888 | chr14_26448324_- | nonsynonymous SNV | ENST00000465357.6 | c.A1087G | p.S363G | 0.25 | 0.001 | -0.37 |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_421887 | chr14_26448309_- | exonic |
| ADediting_421888 | chr14_26448324_- | exonic |
| ADediting_421889 | chr14_26451479_- | intronic |
| ADediting_421890 | chr14_26451488_- | intronic |
| ADediting_421891 | chr14_26451600_- | intronic |
| ADediting_421892 | chr14_26453348_- | intronic |
| ADediting_421893 | chr14_26458555_- | intronic |
| ADediting_421894 | chr14_26458556_- | intronic |
| ADediting_421895 | chr14_26458579_- | intronic |
| ADediting_421896 | chr14_26458585_- | intronic |
| ADediting_421897 | chr14_26458586_- | intronic |
| ADediting_421898 | chr14_26458588_- | intronic |
| ADediting_421899 | chr14_26458595_- | intronic |
| ADediting_421900 | chr14_26458596_- | intronic |
| ADediting_421901 | chr14_26460132_- | intronic |
| ADediting_421902 | chr14_26460140_- | intronic |
| ADediting_421903 | chr14_26461666_- | intronic |
| ADediting_421904 | chr14_26461694_- | intronic |
| ADediting_421905 | chr14_26461712_- | intronic |
| ADediting_421906 | chr14_26461812_- | intronic |
| ADediting_421907 | chr14_26461864_- | intronic |
| ADediting_421908 | chr14_26461901_- | intronic |
| ADediting_421909 | chr14_26461914_- | intronic |
| ADediting_421910 | chr14_26461927_- | intronic |
| ADediting_421911 | chr14_26465205_- | intronic |
| ADediting_421912 | chr14_26465237_- | intronic |
| ADediting_421913 | chr14_26465271_- | intronic |
| ADediting_421914 | chr14_26465286_- | intronic |
| ADediting_421915 | chr14_26465398_- | intronic |
| ADediting_421916 | chr14_26469726_- | intronic |
| ADediting_421917 | chr14_26469880_- | intronic |
| ADediting_421918 | chr14_26471040_- | intronic |
| ADediting_421919 | chr14_26471164_- | intronic |
| ADediting_421920 | chr14_26489724_- | intronic |
| ADediting_421921 | chr14_26489727_- | intronic |
| ADediting_421922 | chr14_26489830_- | intronic |
| ADediting_421923 | chr14_26490752_- | intronic |
| ADediting_421924 | chr14_26492835_- | intronic |
| ADediting_421925 | chr14_26492843_- | intronic |
| ADediting_421926 | chr14_26492889_- | intronic |
| ADediting_421927 | chr14_26511511_- | intronic |
| ADediting_421928 | chr14_26511729_- | intronic |
| ADediting_421929 | chr14_26523889_- | intronic |
| ADediting_421930 | chr14_26524026_- | intronic |
| ADediting_421931 | chr14_26529242_- | intronic |
| ADediting_421932 | chr14_26529275_- | intronic |
| ADediting_421933 | chr14_26529320_- | intronic |
| ADediting_421934 | chr14_26529357_- | intronic |
| ADediting_421935 | chr14_26529365_- | intronic |
| ADediting_421936 | chr14_26535768_- | intronic |
| ADediting_421937 | chr14_26549095_- | intronic |
| ADediting_421938 | chr14_26567388_- | intronic |
| ADediting_421939 | chr14_26570164_- | intronic |
| ADediting_421940 | chr14_26570175_- | intronic |
| ADediting_421941 | chr14_26574861_- | intronic |
| ADediting_1536466 | chr14_26451496_- | intronic |
| ADediting_1536467 | chr14_26453352_- | intronic |
| ADediting_1536468 | chr14_26465204_- | intronic |
| ADediting_1536469 | chr14_26465384_- | intronic |
| ADediting_1536470 | chr14_26469828_- | intronic |
| ADediting_1618231 | chr14_26451398_- | intronic |
| ADediting_1618232 | chr14_26458591_- | intronic |
| ADediting_1618233 | chr14_26461746_- | intronic |
| ADediting_1618234 | chr14_26465251_- | intronic |
| ADediting_1618235 | chr14_26570190_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_421889 | chr14_26451479_- | SINE | Alu | Name=AluSx |
| ADediting_421890 | chr14_26451488_- | SINE | Alu | Name=AluSx |
| ADediting_421891 | chr14_26451600_- | SINE | Alu | Name=AluSx |
| ADediting_421892 | chr14_26453348_- | SINE | Alu | Name=FRAM |
| ADediting_421893 | chr14_26458555_- | LINE | L1 | Name=L1PA16 |
| ADediting_421894 | chr14_26458556_- | LINE | L1 | Name=L1PA16 |
| ADediting_421895 | chr14_26458579_- | LINE | L1 | Name=L1PA16 |
| ADediting_421896 | chr14_26458585_- | LINE | L1 | Name=L1PA16 |
| ADediting_421897 | chr14_26458586_- | LINE | L1 | Name=L1PA16 |
| ADediting_421898 | chr14_26458588_- | LINE | L1 | Name=L1PA16 |
| ADediting_421899 | chr14_26458595_- | LINE | L1 | Name=L1PA16 |
| ADediting_421900 | chr14_26458596_- | LINE | L1 | Name=L1PA16 |
| ADediting_421901 | chr14_26460132_- | LINE | L1 | Name=L1PA17 |
| ADediting_421902 | chr14_26460140_- | LINE | L1 | Name=L1PA17 |
| ADediting_421903 | chr14_26461666_- | SINE | Alu | Name=AluSp |
| ADediting_421904 | chr14_26461694_- | SINE | Alu | Name=AluSp |
| ADediting_421905 | chr14_26461712_- | SINE | Alu | Name=AluSp |
| ADediting_421906 | chr14_26461812_- | SINE | Alu | Name=AluSp |
| ADediting_421907 | chr14_26461864_- | SINE | Alu | Name=AluSp |
| ADediting_421908 | chr14_26461901_- | SINE | Alu | Name=AluSp |
| ADediting_421909 | chr14_26461914_- | SINE | Alu | Name=AluSp |
| ADediting_421910 | chr14_26461927_- | SINE | Alu | Name=AluSp |
| ADediting_421911 | chr14_26465205_- | SINE | Alu | Name=AluSz |
| ADediting_421912 | chr14_26465237_- | SINE | Alu | Name=AluSz |
| ADediting_421913 | chr14_26465271_- | SINE | Alu | Name=AluSz |
| ADediting_421914 | chr14_26465286_- | SINE | Alu | Name=AluSz |
| ADediting_421915 | chr14_26465398_- | SINE | Alu | Name=AluSz |
| ADediting_421916 | chr14_26469726_- | SINE | Alu | Name=AluJr |
| ADediting_421917 | chr14_26469880_- | SINE | Alu | Name=AluJr |
| ADediting_421920 | chr14_26489724_- | SINE | Alu | Name=AluSx |
| ADediting_421921 | chr14_26489727_- | SINE | Alu | Name=AluSx |
| ADediting_421922 | chr14_26489830_- | SINE | Alu | Name=AluSx |
| ADediting_421923 | chr14_26490752_- | SINE | Alu | Name=AluJr |
| ADediting_421924 | chr14_26492835_- | SINE | Alu | Name=AluSz |
| ADediting_421925 | chr14_26492843_- | SINE | Alu | Name=AluSz |
| ADediting_421926 | chr14_26492889_- | SINE | Alu | Name=AluSz |
| ADediting_421927 | chr14_26511511_- | SINE | Alu | Name=AluSc |
| ADediting_421928 | chr14_26511729_- | SINE | Alu | Name=AluSc |
| ADediting_421929 | chr14_26523889_- | SINE | Alu | Name=AluY |
| ADediting_421930 | chr14_26524026_- | SINE | Alu | Name=AluY |
| ADediting_421931 | chr14_26529242_- | SINE | Alu | Name=AluSx1 |
| ADediting_421932 | chr14_26529275_- | SINE | Alu | Name=AluSx1 |
| ADediting_421933 | chr14_26529320_- | SINE | Alu | Name=AluSx1 |
| ADediting_421934 | chr14_26529357_- | SINE | Alu | Name=AluSx1 |
| ADediting_421935 | chr14_26529365_- | SINE | Alu | Name=AluSx1 |
| ADediting_421936 | chr14_26535768_- | SINE | Alu | Name=AluY |
| ADediting_421937 | chr14_26549095_- | SINE | Alu | Name=AluJr |
| ADediting_421938 | chr14_26567388_- | SINE | Alu | Name=AluJo |
| ADediting_421939 | chr14_26570164_- | SINE | Alu | Name=AluSx1 |
| ADediting_421940 | chr14_26570175_- | SINE | Alu | Name=AluSx1 |
| ADediting_421941 | chr14_26574861_- | SINE | Alu | Name=AluJr4 |
| ADediting_1536466 | chr14_26451496_- | SINE | Alu | Name=AluSx |
| ADediting_1536467 | chr14_26453352_- | SINE | Alu | Name=FRAM |
| ADediting_1536468 | chr14_26465204_- | SINE | Alu | Name=AluSz |
| ADediting_1536469 | chr14_26465384_- | SINE | Alu | Name=AluSz |
| ADediting_1536470 | chr14_26469828_- | SINE | Alu | Name=AluJr |
| ADediting_1618231 | chr14_26451398_- | SINE | Alu | Name=AluSx |
| ADediting_1618232 | chr14_26458591_- | LINE | L1 | Name=L1PA16 |
| ADediting_1618233 | chr14_26461746_- | SINE | Alu | Name=AluSp |
| ADediting_1618234 | chr14_26465251_- | SINE | Alu | Name=AluSz |
| ADediting_1618235 | chr14_26570190_- | SINE | Alu | Name=AluSx1 |
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RNA A-to-I editing events in the alternative splicing sites for NOVA1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NOVA1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for NOVA1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for NOVA1 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000139910.20 | ENST00000539517.7 | NOVA1-206 | hsa-miR-4477b | chr14 | 26444934 | 26444940 | 7mer-m8 | 26444933 | 26444957 | 146 | -12.72 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000139910.20 | ENST00000539517.7 | NOVA1-206 | hsa-miR-381-3p | chr14 | 26445853 | 26445859 | 7mer-m8 | 26445852 | 26445873 | 156 | -15.47 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000139910.20 | ENST00000539517.7 | NOVA1-206 | hsa-miR-381-3p | chr14 | 26444387 | 26444393 | 7mer-m8 | 26444386 | 26444411 | 154 | -24.08 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000139910.20 | ENST00000465357.6 | NOVA1-204 | hsa-miR-5682 | chr14 | 26446902 | 26446908 | 7mer-m8 | 26446901 | 26446921 | 162 | -19.03 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000139910.20 | ENST00000539517.7 | NOVA1-206 | hsa-miR-5682 | chr14 | 26446902 | 26446908 | 7mer-m8 | 26446901 | 26446921 | 162 | -19.03 |
| ADediting_496066 | chr15_66496985_- | ENSG00000139910.20 | ENST00000539517.7 | NOVA1-206 | hsa-miR-4512 | chr14 | 26445739 | 26445745 | 7mer-1a | 26445739 | 26445759 | 146 | -22.04 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000139910.20 | ENST00000547619.5 | NOVA1-209 | hsa-miR-4477b | chr14 | 26472074 | 26472081 | 8mer-1a | 26472074 | 26472096 | 144 | -7.41 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000139910.20 | ENST00000547619.5 | NOVA1-209 | hsa-miR-4477b | chr14 | 26472074 | 26472081 | 8mer-1a | 26472074 | 26472096 | 144 | -7.41 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000139910.20 | ENST00000574031.1 | NOVA1-213 | hsa-miR-337-3p | chr14 | 26479688 | 26479695 | 8mer-1a | 26479688 | 26479709 | 152 | -6.98 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000139910.20 | ENST00000539517.7 | NOVA1-206 | hsa-miR-641 | chr14 | 26443660 | 26443666 | 7mer-m8 | 26443659 | 26443687 | 148 | -15.62 |
| ADediting_1596844 | chr1_162342605_+ | ENSG00000139910.20 | ENST00000539517.7 | NOVA1-206 | hsa-miR-556-3p | chr14 | 26444131 | 26444137 | 7mer-m8 | 26444130 | 26444151 | 152 | -12.23 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000139910.20 | ENST00000539517.7 | NOVA1-206 | hsa-miR-641 | chr14 | 26443660 | 26443666 | 7mer-m8 | 26443659 | 26443687 | 148 | -15.62 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000139910.20 | ENST00000539517.7 | NOVA1-206 | hsa-miR-5682 | chr14 | 26444318 | 26444324 | 7mer-m8 | 26444317 | 26444340 | 148 | -14.73 |
| ADediting_496066 | chr15_66496985_- | ENSG00000139910.20 | ENST00000539517.7 | NOVA1-206 | hsa-miR-4512 | chr14 | 26444162 | 26444169 | 8mer-1a | 26444162 | 26444184 | 146 | -16.54 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000139910.20 | ENST00000539517.7 | NOVA1-206 | hsa-miR-1273h-3p | chr14 | 26444730 | 26444736 | 7mer-m8 | 26444729 | 26444750 | 140 | -11.77 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000139910.20 | ENST00000465357.6 | NOVA1-204 | hsa-miR-4775 | chr14 | 26447392 | 26447398 | 7mer-m8 | 26447391 | 26447415 | 150 | -7.4 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000139910.20 | ENST00000539517.7 | NOVA1-206 | hsa-miR-4775 | chr14 | 26443159 | 26443166 | 8mer-1a | 26443159 | 26443180 | 143 | -5.32 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000139910.20 | ENST00000539517.7 | NOVA1-206 | hsa-miR-4775 | chr14 | 26444900 | 26444906 | 7mer-m8 | 26444899 | 26444920 | 153 | -4.2 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000139910.20 | ENST00000539517.7 | NOVA1-206 | hsa-miR-4775 | chr14 | 26445267 | 26445273 | 7mer-m8 | 26445266 | 26445285 | 149 | -7.87 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000139910.20 | ENST00000539517.7 | NOVA1-206 | hsa-miR-4775 | chr14 | 26447392 | 26447398 | 7mer-m8 | 26447391 | 26447415 | 150 | -7.4 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000139910.20 | ENST00000574031.1 | NOVA1-213 | hsa-miR-4775 | chr14 | 26479669 | 26479675 | 7mer-m8 | 26479668 | 26479692 | 145 | -7.18 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for NOVA1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000539517.7 | protein_coding |  |  |
| ENST00000465357.6 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_421887 | ENST00000539517.7 | chr14_26448309_- | 1771 | -1792.70 | -1789.10 | -1799.30 |
| ADediting_421888 | ENST00000539517.7 | chr14_26448324_- | 1756 | -1792.60 | -1789.10 | -1799.30 |
| ADediting_421887 | ENST00000465357.6 | chr14_26448309_- | 1152 | -1015.31 | -1008.61 | -1021.91 |
| ADediting_421888 | ENST00000465357.6 | chr14_26448324_- | 1137 | -1015.21 | -1008.61 | -1021.91 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for NOVA1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_421888 | chr14_26448324_- | 5.029854077587e-13 | 0.395104290512862 | 5.04930402624741e-18 | 0.464840062595822 | 0.027631539276388 | -0.125105903544197 |
| CER | ADediting_421888 | chr14_26448324_- | 0.000130821455455421 | 0.307282575386945 | 0.000244945106558691 | 0.295216478992205 | 0.443006597016062 | 0.0631009905805139 |
| TCX | ADediting_421888 | chr14_26448324_- | 4.97604451637731e-13 | 0.545981535171389 | 5.82381080944766e-24 | 0.706256218574357 | 0.000631880690009457 | -0.275912974581833 |
| STG | ADediting_421888 | chr14_26448324_- | 3.51349405547918e-05 | 0.435224406667707 | 7.40362520490029e-06 | 0.467338108922381 | 0.0212036106148962 | -0.251143038891416 |
| STG | ADediting_421894 | chr14_26458556_- | 0.00437193801709536 | 0.307978660877519 | 0.00340797936867498 | 0.316010462796329 | 0.771703154799305 | 0.0321309942426657 |
| CER | ADediting_421895 | chr14_26458579_- | 5.18150264983669e-07 | 0.396249652711472 | 0.0015302823333585 | 0.256539719390137 | 0.999947156731968 | 5.45321159313209e-06 |
| STG | ADediting_421895 | chr14_26458579_- | 0.00411172711205022 | 0.309977549891679 | 0.000665880129752661 | 0.363957198688439 | 0.805139131260695 | 0.0273217179692695 |
| STG | ADediting_421896 | chr14_26458585_- | 0.00500450535979816 | 0.303528592475985 | 0.003641598566333 | 0.313893588220095 | 0.96710442623612 | 0.00456809720135953 |
| STG | ADediting_421907 | chr14_26461864_- | 0.00181096262548319 | 0.335481153554883 | 0.0159911430545877 | 0.262169205149081 | 0.351641900028157 | 0.102896790249766 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 3.84629420191307e-20 | 0.490163406428329 | 4.90779340372168e-51 | 0.721200989682327 | 0.870562103560946 | -0.00929196534854076 |
| AC | 5.14278412646285e-96 | 0.908600565266262 | 1.54226331167983e-83 | 0.88324535794105 | 6.64279977496577e-12 | 0.416397118005563 |
| PCC | 2.79143143593156e-61 | 0.874448806082271 | 3.94799200201554e-71 | 0.90266969415194 | 0.230504990328447 | 0.087167816769175 |
| CER | 8.24419506819657e-06 | 0.355089656650484 | 0.000303310751622506 | 0.290981305571162 | 0.000223148603786587 | -0.297043004765478 |
| TCX | 8.04222462703147e-14 | 0.561184202245258 | 9.7741963080943e-17 | 0.61126127918879 | 0.513810774167343 | -0.0537212126236145 |
| FP | 9.41336688056171e-40 | 0.793149929062494 | 2.15039308958388e-46 | 0.829515366591451 | 0.0114901108176819 | 0.189059176676452 |
| IFG | 3.5229993949398e-07 | 0.826689539087246 | 5.85083202102102e-06 | 0.773221148488257 | 0.319574793927169 | 0.207512398546905 |
| PG | 3.40011682348262e-61 | 0.879355872869411 | 2.85974455373966e-47 | 0.823985603043084 | 0.365019135527752 | -0.0667956820496293 |
| STG | 9.47208233549401e-20 | 0.798356916281576 | 3.72310073973724e-20 | 0.803421853887831 | 0.917916106366464 | 0.0114153458829104 |
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Relation with AD stages for NOVA1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| TCX | ADediting_421918 | chr14_26471040_- | 8.83528146661836e-05 | 0.371480613747732 |
| IFG | ADediting_421887 | chr14_26448309_- | 0.026500199952627 | -0.443177372403165 |
| IFG | ADediting_421888 | chr14_26448324_- | 0.0195067248141111 | -0.463873203635081 |
| PG | ADediting_421888 | chr14_26448324_- | 1.10310184467299e-08 | -0.403725232253959 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for NOVA1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NOVA1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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