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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for NAGLU

check button Gene summary
Gene informationGene symbol

NAGLU

Gene ID

4669

Gene nameN-acetyl-alpha-glucosaminidase
SynonymsCMT2V|MPS-IIIB|MPS3B|NAG|UFHSD
Cytomap

17q21.2

Type of geneprotein-coding
Descriptionalpha-N-acetylglucosaminidaseN-acetylglucosaminidase, alphatesticular tissue protein Li 18
Modification date20200313
UniProtAcc

P54802,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for NAGLU

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_623327(42538938, +), ADediting_623328(42539002, +), ADediting_623329(42539041, +), ADediting_623330(42539042, +), ADediting_623331(42539849, +), ADediting_623332(42539858, +), ADediting_623333(42539911, +), ADediting_623334(42539912, +), ADediting_623335(42539937, +), ADediting_623336(42539949, +), ADediting_623337(42539953, +), ADediting_623338(42539954, +), ADediting_623339(42539963, +), ADediting_623340(42539967, +), ADediting_623341(42539971, +), ADediting_623342(42539993, +), ADediting_623343(42539994, +), ADediting_623344(42539999, +), ADediting_623345(42540003, +), ADediting_623346(42540034, +), ADediting_623347(42540035, +), ADediting_623348(42540039, +), ADediting_623349(42540435, +), ADediting_623350(42540442, +), ADediting_623351(42540480, +), ADediting_623352(42540513, +), ADediting_623353(42540549, +), ADediting_623354(42540575, +), ADediting_623355(42540585, +), ADediting_623356(42540641, +), ADediting_623357(42540649, +), ADediting_623358(42540661, +), ADediting_623360(42541925, +), ADediting_623361(42541932, +), ADediting_623362(42541954, +), ADediting_623363(42541962, +), ADediting_623364(42541965, +), ADediting_623365(42541994, +), ADediting_623366(42542000, +), ADediting_623367(42542001, +), ADediting_623368(42542030, +), ADediting_623370(42542046, +), ADediting_623371(42542086, +), ADediting_623372(42542124, +), ADediting_623373(42542162, +), ADediting_623374(42542163, +), ADediting_623375(42542229, +), ADediting_623376(42542264, +), ADediting_623377(42542268, +), ADediting_623378(42542274, +), ADediting_623379(42542284, +), ADediting_623380(42542299, +), ADediting_623381(42542316, +), ADediting_623382(42542382, +), ADediting_623383(42542385, +), ADediting_623384(42542395, +), ADediting_623385(42542398, +), ADediting_623386(42542450, +), ADediting_623387(42542463, +), ADediting_623388(42542517, +), ADediting_623389(42542520, +), ADediting_623390(42542555, +), ADediting_623391(42542558, +), ADediting_623392(42542563, +), ADediting_623393(42542593, +), ADediting_623394(42542594, +), ADediting_623395(42542612, +), ADediting_623396(42542623, +), ADediting_623397(42542633, +), ADediting_623398(42542659, +), ADediting_623399(42542660, +), ADediting_623400(42542674, +), ADediting_623401(42542683, +), ADediting_623402(42542729, +), ADediting_623403(42542746, +), ADediting_623404(42542759, +), ADediting_1546644(42538946, +), ADediting_1546645(42539071, +), ADediting_1546646(42539961, +), ADediting_1546648(42542244, +), ADediting_1546649(42542247, +), ADediting_1546650(42542379, +), ADediting_1546651(42542472, +),

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RNA editing positional annotations for NAGLU using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_623327chr17_42538938_+ncRNA_intronic
ADediting_623328chr17_42539002_+ncRNA_intronic
ADediting_623329chr17_42539041_+ncRNA_intronic
ADediting_623330chr17_42539042_+ncRNA_intronic
ADediting_623331chr17_42539849_+ncRNA_intronic
ADediting_623332chr17_42539858_+ncRNA_intronic
ADediting_623333chr17_42539911_+ncRNA_intronic
ADediting_623334chr17_42539912_+ncRNA_intronic
ADediting_623335chr17_42539937_+ncRNA_intronic
ADediting_623336chr17_42539949_+ncRNA_intronic
ADediting_623337chr17_42539953_+ncRNA_intronic
ADediting_623338chr17_42539954_+ncRNA_intronic
ADediting_623339chr17_42539963_+ncRNA_intronic
ADediting_623340chr17_42539967_+ncRNA_intronic
ADediting_623341chr17_42539971_+ncRNA_intronic
ADediting_623342chr17_42539993_+ncRNA_intronic
ADediting_623343chr17_42539994_+ncRNA_intronic
ADediting_623344chr17_42539999_+ncRNA_intronic
ADediting_623345chr17_42540003_+ncRNA_intronic
ADediting_623346chr17_42540034_+ncRNA_intronic
ADediting_623347chr17_42540035_+ncRNA_intronic
ADediting_623348chr17_42540039_+ncRNA_intronic
ADediting_623349chr17_42540435_+ncRNA_intronic
ADediting_623350chr17_42540442_+ncRNA_intronic
ADediting_623351chr17_42540480_+ncRNA_intronic
ADediting_623352chr17_42540513_+ncRNA_intronic
ADediting_623353chr17_42540549_+ncRNA_intronic
ADediting_623354chr17_42540575_+ncRNA_intronic
ADediting_623355chr17_42540585_+ncRNA_intronic
ADediting_623356chr17_42540641_+ncRNA_intronic
ADediting_623357chr17_42540649_+ncRNA_intronic
ADediting_623358chr17_42540661_+ncRNA_intronic
ADediting_623360chr17_42541925_+ncRNA_intronic
ADediting_623361chr17_42541932_+ncRNA_intronic
ADediting_623362chr17_42541954_+ncRNA_intronic
ADediting_623363chr17_42541962_+ncRNA_intronic
ADediting_623364chr17_42541965_+ncRNA_intronic
ADediting_623365chr17_42541994_+ncRNA_intronic
ADediting_623366chr17_42542000_+ncRNA_intronic
ADediting_623367chr17_42542001_+ncRNA_intronic
ADediting_623368chr17_42542030_+ncRNA_intronic
ADediting_623370chr17_42542046_+ncRNA_intronic
ADediting_623371chr17_42542086_+ncRNA_intronic
ADediting_623372chr17_42542124_+ncRNA_intronic
ADediting_623373chr17_42542162_+ncRNA_intronic
ADediting_623374chr17_42542163_+ncRNA_intronic
ADediting_623375chr17_42542229_+ncRNA_intronic
ADediting_623376chr17_42542264_+ncRNA_intronic
ADediting_623377chr17_42542268_+ncRNA_intronic
ADediting_623378chr17_42542274_+ncRNA_intronic
ADediting_623379chr17_42542284_+ncRNA_intronic
ADediting_623380chr17_42542299_+ncRNA_intronic
ADediting_623381chr17_42542316_+ncRNA_intronic
ADediting_623382chr17_42542382_+ncRNA_intronic
ADediting_623383chr17_42542385_+ncRNA_intronic
ADediting_623384chr17_42542395_+ncRNA_intronic
ADediting_623385chr17_42542398_+ncRNA_intronic
ADediting_623386chr17_42542450_+ncRNA_intronic
ADediting_623387chr17_42542463_+ncRNA_intronic
ADediting_623388chr17_42542517_+ncRNA_intronic
ADediting_623389chr17_42542520_+ncRNA_intronic
ADediting_623390chr17_42542555_+ncRNA_intronic
ADediting_623391chr17_42542558_+ncRNA_intronic
ADediting_623392chr17_42542563_+ncRNA_intronic
ADediting_623393chr17_42542593_+ncRNA_intronic
ADediting_623394chr17_42542594_+ncRNA_intronic
ADediting_623395chr17_42542612_+ncRNA_intronic
ADediting_623396chr17_42542623_+ncRNA_intronic
ADediting_623397chr17_42542633_+ncRNA_intronic
ADediting_623398chr17_42542659_+ncRNA_intronic
ADediting_623399chr17_42542660_+ncRNA_intronic
ADediting_623400chr17_42542674_+ncRNA_intronic
ADediting_623401chr17_42542683_+ncRNA_intronic
ADediting_623402chr17_42542729_+ncRNA_intronic
ADediting_623403chr17_42542746_+ncRNA_intronic
ADediting_623404chr17_42542759_+ncRNA_intronic
ADediting_1546644chr17_42538946_+ncRNA_intronic
ADediting_1546645chr17_42539071_+ncRNA_intronic
ADediting_1546646chr17_42539961_+ncRNA_intronic
ADediting_1546648chr17_42542244_+ncRNA_intronic
ADediting_1546649chr17_42542247_+ncRNA_intronic
ADediting_1546650chr17_42542379_+ncRNA_intronic
ADediting_1546651chr17_42542472_+ncRNA_intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_623327chr17_42538938_+SINEAluName=AluSx
ADediting_623328chr17_42539002_+SINEAluName=AluSx
ADediting_623329chr17_42539041_+SINEAluName=AluSx
ADediting_623330chr17_42539042_+SINEAluName=AluSx
ADediting_623331chr17_42539849_+SINEAluName=AluSx1
ADediting_623332chr17_42539858_+SINEAluName=AluSx1
ADediting_623333chr17_42539911_+SINEAluName=AluSx1
ADediting_623334chr17_42539912_+SINEAluName=AluSx1
ADediting_623335chr17_42539937_+SINEAluName=AluSx1
ADediting_623336chr17_42539949_+SINEAluName=AluSx1
ADediting_623337chr17_42539953_+SINEAluName=AluSx1
ADediting_623338chr17_42539954_+SINEAluName=AluSx1
ADediting_623339chr17_42539963_+SINEAluName=AluSx1
ADediting_623340chr17_42539967_+SINEAluName=AluSx1
ADediting_623341chr17_42539971_+SINEAluName=AluSx1
ADediting_623342chr17_42539993_+SINEAluName=AluSx1
ADediting_623343chr17_42539994_+SINEAluName=AluSx1
ADediting_623344chr17_42539999_+SINEAluName=AluSx1
ADediting_623345chr17_42540003_+SINEAluName=AluSx1
ADediting_623346chr17_42540034_+SINEAluName=AluSx1
ADediting_623347chr17_42540035_+SINEAluName=AluSx1
ADediting_623348chr17_42540039_+SINEAluName=AluSx1
ADediting_623349chr17_42540435_+SINEAluName=AluY
ADediting_623350chr17_42540442_+SINEAluName=AluY
ADediting_623351chr17_42540480_+SINEAluName=AluY
ADediting_623352chr17_42540513_+SINEAluName=AluY
ADediting_623353chr17_42540549_+SINEAluName=AluY
ADediting_623354chr17_42540575_+SINEAluName=AluY
ADediting_623355chr17_42540585_+SINEAluName=AluY
ADediting_623356chr17_42540641_+SINEAluName=AluY
ADediting_623357chr17_42540649_+SINEAluName=AluY
ADediting_623358chr17_42540661_+SINEAluName=AluY
ADediting_623360chr17_42541925_+SINEAluName=AluSx1
ADediting_623361chr17_42541932_+SINEAluName=AluSx1
ADediting_623362chr17_42541954_+SINEAluName=AluSx1
ADediting_623363chr17_42541962_+SINEAluName=AluSx1
ADediting_623364chr17_42541965_+SINEAluName=AluSx1
ADediting_623365chr17_42541994_+SINEAluName=AluSx1
ADediting_623366chr17_42542000_+SINEAluName=AluSx1
ADediting_623367chr17_42542001_+SINEAluName=AluSx1
ADediting_623368chr17_42542030_+SINEAluName=AluSx1
ADediting_623370chr17_42542046_+SINEAluName=AluSx1
ADediting_623371chr17_42542086_+SINEAluName=AluSx1
ADediting_623372chr17_42542124_+SINEAluName=AluSx1
ADediting_623373chr17_42542162_+SINEAluName=AluSx1
ADediting_623374chr17_42542163_+SINEAluName=AluSx1
ADediting_623375chr17_42542229_+SINEAluName=AluSx1
ADediting_623376chr17_42542264_+SINEAluName=AluSx1
ADediting_623377chr17_42542268_+SINEAluName=AluSx1
ADediting_623378chr17_42542274_+SINEAluName=AluSx1
ADediting_623379chr17_42542284_+SINEAluName=AluSx1
ADediting_623380chr17_42542299_+SINEAluName=AluSx1
ADediting_623381chr17_42542316_+SINEAluName=AluSx1
ADediting_623382chr17_42542382_+SINEAluName=AluSx1
ADediting_623383chr17_42542385_+SINEAluName=AluSx1
ADediting_623384chr17_42542395_+SINEAluName=AluSx1
ADediting_623385chr17_42542398_+SINEAluName=AluSx1
ADediting_623386chr17_42542450_+SINEAluName=AluSx1
ADediting_623387chr17_42542463_+SINEAluName=AluSx1
ADediting_623388chr17_42542517_+SINEAluName=AluSz6
ADediting_623389chr17_42542520_+SINEAluName=AluSz6
ADediting_623390chr17_42542555_+SINEAluName=AluSz6
ADediting_623391chr17_42542558_+SINEAluName=AluSz6
ADediting_623392chr17_42542563_+SINEAluName=AluSz6
ADediting_623393chr17_42542593_+SINEAluName=AluSz6
ADediting_623394chr17_42542594_+SINEAluName=AluSz6
ADediting_623395chr17_42542612_+SINEAluName=AluSz6
ADediting_623396chr17_42542623_+SINEAluName=AluSz6
ADediting_623397chr17_42542633_+SINEAluName=AluSz6
ADediting_623398chr17_42542659_+SINEAluName=AluSz6
ADediting_623399chr17_42542660_+SINEAluName=AluSz6
ADediting_623400chr17_42542674_+SINEAluName=AluSz6
ADediting_623401chr17_42542683_+SINEAluName=AluSz6
ADediting_623402chr17_42542729_+SINEAluName=AluSz6
ADediting_623403chr17_42542746_+SINEAluName=AluSz6
ADediting_623404chr17_42542759_+SINEAluName=AluSz6
ADediting_1546644chr17_42538946_+SINEAluName=AluSx
ADediting_1546645chr17_42539071_+SINEAluName=AluSx
ADediting_1546646chr17_42539961_+SINEAluName=AluSx1
ADediting_1546648chr17_42542244_+SINEAluName=AluSx1
ADediting_1546649chr17_42542247_+SINEAluName=AluSx1
ADediting_1546650chr17_42542379_+SINEAluName=AluSx1
ADediting_1546651chr17_42542472_+SINEAluName=AluSx1

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RNA A-to-I editing events in the alternative splicing sites for NAGLU

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NAGLU

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
boxplot
boxplot
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for NAGLU

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for NAGLU


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_496066chr15_66496985_-ENSG00000108784.10ENST00000225927.7NAGLU-201hsa-miR-4512chr1742544337425443448mer-1a4254432442544344150-25.48

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1556067chr19_40282625_-ENSG00000108784.10ENST00000591587.1NAGLU-204hsa-miR-641chr1742544104425441107mer-m84254408842544111140-9.07
ADediting_1631458chr19_40282624_-ENSG00000108784.10ENST00000591587.1NAGLU-204hsa-miR-641chr1742544104425441107mer-m84254408842544111140-9.07
ADediting_291761chr11_93733708_-ENSG00000108784.10ENST00000591587.1NAGLU-204hsa-miR-1304-3pchr1742543895425439017mer-m84254388042543902146-19.14

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for NAGLU

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for NAGLU

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC2.46819822657094e-140.4149836495000445.8931083592195e-110.3606795402738137.76163808844548e-340.616467807850781
AC4.58648937019277e-390.7062149246287861.21291613030503e-230.5775659332673782.17147009751724e-260.605383878969852
PCC6.71016063753151e-100.4277972355377391.33657517654743e-070.3703689557987953.86987084114526e-100.433189227187651
CER1.20241840593313e-070.4159180407692670.01817715978519850.1926569722451410.006409560781191680.221660204009321
TCX6.7950333415565e-050.3193523885411350.0153904109450417-0.1975408908244741.71864115696539e-250.722466072933505
FP4.45112796032809e-060.3362682516849712.64445283338513e-050.3093784796878531.38154579023418e-230.659501969348084
IFG0.1071061882288390.3300597406140480.272479687894270.2282462902497410.0002453756897538270.670414938037416
PG0.101057811460501-0.1206058301525150.0102898269375608-0.1877331634293368.55333874960114e-220.627969902678609
STG0.007375687807167450.2903686840582530.86818072360673-0.01838270528974383.22846585819374e-160.747318102606474

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Relation with AD stages for NAGLU

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
TCX9.20745340586982e-120.601493625634345
IFG0.03565627416692030.421919819165728
PG1.91921932905069e-050.307822833798121

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RelatedDrugs for NAGLU

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAGLU

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
NAGLUC0086648MPS III B15CTD_human;ORPHANET;UNIPROT
NAGLUC0391976Pain Disorder2GENOMICS_ENGLAND
NAGLUC0004138Ataxias, Hereditary1GENOMICS_ENGLAND
NAGLUC0020796Profound Mental Retardation1CTD_human
NAGLUC0025363Mental Retardation, Psychosocial1CTD_human
NAGLUC0033578Prostatic Neoplasms1CTD_human
NAGLUC0376358Malignant neoplasm of prostate1CTD_human
NAGLUC0917816Mental deficiency1CTD_human
NAGLUC3714756Intellectual Disability1CTD_human;GENOMICS_ENGLAND
NAGLUC4225306CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2V1CTD_human;ORPHANET;UNIPROT