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Center for Computational Systems Medicine
Soverview

Gene summary

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RNA A-to-I events

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Differntial gene expression between RNA A-to-I edited versus non-edited samples

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Protein coding region RNA A-to-I editings

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The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

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Relation with ADAR

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Relation with AD stages

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Related drugs with this gene

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Related diseases with this gene


Gene summary for TMEM198B

check button Gene summary
Gene informationGene symbol

TMEM198B

Gene ID

440104

Gene nametransmembrane protein 198B (pseudogene)
Synonyms-
Cytomap

12q13.2

Type of genepseudo
Description1110012D08Rik pseudogenetransmembrane protein 198, pseudogene
Modification date20200313
UniProtAcc

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for TMEM198B

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_356921(55833818, +), ADediting_356922(55833828, +), ADediting_356923(55833834, +), ADediting_356924(55833836, +), ADediting_356925(55833837, +), ADediting_356926(55833842, +), ADediting_356927(55833845, +), ADediting_356928(55833858, +), ADediting_356929(55833859, +), ADediting_356930(55833880, +), ADediting_356931(55833903, +), ADediting_356932(55833904, +), ADediting_356933(55833912, +), ADediting_356934(55833914, +), ADediting_356935(55833928, +), ADediting_356936(55833979, +), ADediting_356937(55833989, +), ADediting_356938(55834002, +), ADediting_356939(55834006, +), ADediting_356940(55834020, +), ADediting_356941(55834021, +), ADediting_356942(55834050, +), ADediting_356943(55834065, +), ADediting_356944(55834082, +), ADediting_356945(55834295, +), ADediting_356946(55834303, +), ADediting_356947(55834317, +), ADediting_356948(55834325, +), ADediting_356949(55834338, +), ADediting_356950(55834363, +), ADediting_356951(55834364, +), ADediting_356952(55834368, +), ADediting_356953(55834374, +), ADediting_356954(55834381, +), ADediting_356955(55834393, +), ADediting_356956(55834403, +), ADediting_356957(55834429, +), ADediting_356958(55834438, +), ADediting_356959(55834444, +), ADediting_356960(55834447, +), ADediting_356961(55834461, +), ADediting_356962(55834464, +), ADediting_356963(55834469, +), ADediting_356964(55834473, +), ADediting_356965(55834492, +), ADediting_356966(55834507, +), ADediting_356967(55834511, +), ADediting_356968(55834516, +), ADediting_356969(55834525, +), ADediting_356970(55834526, +), ADediting_356971(55834538, +), ADediting_356972(55834540, +), ADediting_356973(55834541, +), ADediting_356974(55834823, +), ADediting_1533251(55833900, +), ADediting_1533252(55833925, +), ADediting_1533253(55833931, +), ADediting_1533254(55835061, +),

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RNA editing positional annotations for TMEM198B using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_356921chr12_55833818_+ncRNA_intronic
ADediting_356922chr12_55833828_+ncRNA_intronic
ADediting_356923chr12_55833834_+ncRNA_intronic
ADediting_356924chr12_55833836_+ncRNA_intronic
ADediting_356925chr12_55833837_+ncRNA_intronic
ADediting_356926chr12_55833842_+ncRNA_intronic
ADediting_356927chr12_55833845_+ncRNA_intronic
ADediting_356928chr12_55833858_+ncRNA_intronic
ADediting_356929chr12_55833859_+ncRNA_intronic
ADediting_356930chr12_55833880_+ncRNA_intronic
ADediting_356931chr12_55833903_+ncRNA_intronic
ADediting_356932chr12_55833904_+ncRNA_intronic
ADediting_356933chr12_55833912_+ncRNA_intronic
ADediting_356934chr12_55833914_+ncRNA_intronic
ADediting_356935chr12_55833928_+ncRNA_intronic
ADediting_356936chr12_55833979_+ncRNA_intronic
ADediting_356937chr12_55833989_+ncRNA_intronic
ADediting_356938chr12_55834002_+ncRNA_intronic
ADediting_356939chr12_55834006_+ncRNA_intronic
ADediting_356940chr12_55834020_+ncRNA_intronic
ADediting_356941chr12_55834021_+ncRNA_intronic
ADediting_356942chr12_55834050_+ncRNA_intronic
ADediting_356943chr12_55834065_+ncRNA_intronic
ADediting_356944chr12_55834082_+ncRNA_intronic
ADediting_356945chr12_55834295_+ncRNA_exonic
ADediting_356946chr12_55834303_+ncRNA_exonic
ADediting_356947chr12_55834317_+ncRNA_exonic
ADediting_356948chr12_55834325_+ncRNA_exonic
ADediting_356949chr12_55834338_+ncRNA_exonic
ADediting_356950chr12_55834363_+ncRNA_intronic
ADediting_356951chr12_55834364_+ncRNA_intronic
ADediting_356952chr12_55834368_+ncRNA_intronic
ADediting_356953chr12_55834374_+ncRNA_intronic
ADediting_356954chr12_55834381_+ncRNA_intronic
ADediting_356955chr12_55834393_+ncRNA_intronic
ADediting_356956chr12_55834403_+ncRNA_intronic
ADediting_356957chr12_55834429_+ncRNA_intronic
ADediting_356958chr12_55834438_+ncRNA_intronic
ADediting_356959chr12_55834444_+ncRNA_intronic
ADediting_356960chr12_55834447_+ncRNA_intronic
ADediting_356961chr12_55834461_+ncRNA_intronic
ADediting_356962chr12_55834464_+ncRNA_intronic
ADediting_356963chr12_55834469_+ncRNA_intronic
ADediting_356964chr12_55834473_+ncRNA_intronic
ADediting_356965chr12_55834492_+ncRNA_intronic
ADediting_356966chr12_55834507_+ncRNA_intronic
ADediting_356967chr12_55834511_+ncRNA_intronic
ADediting_356968chr12_55834516_+ncRNA_intronic
ADediting_356969chr12_55834525_+ncRNA_intronic
ADediting_356970chr12_55834526_+ncRNA_intronic
ADediting_356971chr12_55834538_+ncRNA_intronic
ADediting_356972chr12_55834540_+ncRNA_intronic
ADediting_356973chr12_55834541_+ncRNA_intronic
ADediting_356974chr12_55834823_+ncRNA_intronic
ADediting_1533251chr12_55833900_+ncRNA_intronic
ADediting_1533252chr12_55833925_+ncRNA_intronic
ADediting_1533253chr12_55833931_+ncRNA_intronic
ADediting_1533254chr12_55835061_+ncRNA_exonic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_356921chr12_55833818_+SINEAluName=AluY
ADediting_356922chr12_55833828_+SINEAluName=AluY
ADediting_356923chr12_55833834_+SINEAluName=AluY
ADediting_356924chr12_55833836_+SINEAluName=AluY
ADediting_356925chr12_55833837_+SINEAluName=AluY
ADediting_356926chr12_55833842_+SINEAluName=AluY
ADediting_356927chr12_55833845_+SINEAluName=AluY
ADediting_356928chr12_55833858_+SINEAluName=AluY
ADediting_356929chr12_55833859_+SINEAluName=AluY
ADediting_356930chr12_55833880_+SINEAluName=AluY
ADediting_356931chr12_55833903_+SINEAluName=AluY
ADediting_356932chr12_55833904_+SINEAluName=AluY
ADediting_356933chr12_55833912_+SINEAluName=AluY
ADediting_356934chr12_55833914_+SINEAluName=AluY
ADediting_356935chr12_55833928_+SINEAluName=AluY
ADediting_356936chr12_55833979_+SINEAluName=AluY
ADediting_356937chr12_55833989_+SINEAluName=AluY
ADediting_356938chr12_55834002_+SINEAluName=AluY
ADediting_356939chr12_55834006_+SINEAluName=AluY
ADediting_356940chr12_55834020_+SINEAluName=AluY
ADediting_356941chr12_55834021_+SINEAluName=AluY
ADediting_356942chr12_55834050_+SINEAluName=AluY
ADediting_356943chr12_55834065_+SINEAluName=AluY
ADediting_356944chr12_55834082_+SINEAluName=AluY
ADediting_356945chr12_55834295_+SINEAluName=AluSz
ADediting_356946chr12_55834303_+SINEAluName=AluSz
ADediting_356947chr12_55834317_+SINEAluName=AluSz
ADediting_356948chr12_55834325_+SINEAluName=AluSz
ADediting_356949chr12_55834338_+SINEAluName=AluSz
ADediting_356950chr12_55834363_+SINEAluName=AluSz
ADediting_356951chr12_55834364_+SINEAluName=AluSz
ADediting_356952chr12_55834368_+SINEAluName=AluSz
ADediting_356953chr12_55834374_+SINEAluName=AluSz
ADediting_356954chr12_55834381_+SINEAluName=AluSz
ADediting_356955chr12_55834393_+SINEAluName=AluSz
ADediting_356956chr12_55834403_+SINEAluName=AluSz
ADediting_356957chr12_55834429_+SINEAluName=AluSz
ADediting_356958chr12_55834438_+SINEAluName=AluSz
ADediting_356959chr12_55834444_+SINEAluName=AluSz
ADediting_356960chr12_55834447_+SINEAluName=AluSz
ADediting_356961chr12_55834461_+SINEAluName=AluSz
ADediting_356962chr12_55834464_+SINEAluName=AluSz
ADediting_356963chr12_55834469_+SINEAluName=AluSz
ADediting_356964chr12_55834473_+SINEAluName=AluSz
ADediting_356965chr12_55834492_+SINEAluName=AluSz
ADediting_356966chr12_55834507_+SINEAluName=AluSz
ADediting_356967chr12_55834511_+SINEAluName=AluSz
ADediting_356968chr12_55834516_+SINEAluName=AluSz
ADediting_356969chr12_55834525_+SINEAluName=AluSz
ADediting_356970chr12_55834526_+SINEAluName=AluSz
ADediting_356971chr12_55834538_+SINEAluName=AluSz
ADediting_356972chr12_55834540_+SINEAluName=AluSz
ADediting_356973chr12_55834541_+SINEAluName=AluSz
ADediting_1533251chr12_55833900_+SINEAluName=AluY
ADediting_1533252chr12_55833925_+SINEAluName=AluY
ADediting_1533253chr12_55833931_+SINEAluName=AluY

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RNA A-to-I editing events in the alternative splicing sites for TMEM198B

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TMEM198B

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for TMEM198B

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for TMEM198B

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1533254chr12_55835061_+ENSG00000182796.14ENST00000471276.5TMEM198B-201hsa-miR-4281chr1255835060558350667mer-m85583505055835067147-24.03
ADediting_1533254chr12_55835061_+ENSG00000182796.14ENST00000478241.6TMEM198B-202hsa-miR-4281chr1255835060558350667mer-m85583505055835067147-24.03
ADediting_1533254chr12_55835061_+ENSG00000182796.14ENST00000482378.6TMEM198B-203hsa-miR-4281chr1255835060558350667mer-m85583505055835067147-24.03
ADediting_1533254chr12_55835061_+ENSG00000182796.14ENST00000487582.1TMEM198B-205hsa-miR-4281chr1255835060558350667mer-m85583505055835067147-24.03
ADediting_1533254chr12_55835061_+ENSG00000182796.14ENST00000508246.6TMEM198B-206hsa-miR-4281chr1255835060558350667mer-m85583505055835067147-24.03
ADediting_1533254chr12_55835061_+ENSG00000182796.14ENST00000636428.1TMEM198B-209hsa-miR-4281chr1255835060558350667mer-m85583505055835067147-24.03
ADediting_356947chr12_55834317_+ENSG00000182796.14ENST00000636659.1TMEM198B-210hsa-miR-4793-3pchr1255834314558343207mer-m85583429955834321154-22.82
ADediting_356947chr12_55834317_+ENSG00000182796.14ENST00000636659.1TMEM198B-210hsa-miR-7703chr1255834313558343197mer-m85583429855834320154-20.16
ADediting_356947chr12_55834317_+ENSG00000182796.14ENST00000637092.1TMEM198B-213hsa-miR-4793-3pchr1255834314558343207mer-m85583429955834321154-22.82
ADediting_356947chr12_55834317_+ENSG00000182796.14ENST00000637092.1TMEM198B-213hsa-miR-7703chr1255834313558343197mer-m85583429855834320154-20.16

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_356945chr12_55834295_+ENSG00000182796.14ENST00000636659.1TMEM198B-210hsa-miR-3672chr1255834289558342957mer-m85583353055834296146-13.25
ADediting_356945chr12_55834295_+ENSG00000182796.14ENST00000636659.1TMEM198B-210hsa-miR-5586-3pchr1255834293558342997mer-m85583353455834300146-14.33
ADediting_356945chr12_55834295_+ENSG00000182796.14ENST00000636659.1TMEM198B-210hsa-miR-6864-3pchr1255834289558342957mer-m85583353255834296147-17.44
ADediting_356945chr12_55834295_+ENSG00000182796.14ENST00000636659.1TMEM198B-210hsa-miR-759chr1255834294558343007mer-m85583353855834301143-12.38
ADediting_356945chr12_55834295_+ENSG00000182796.14ENST00000637092.1TMEM198B-213hsa-miR-3672chr1255834289558342957mer-m85583353055834296146-13.25
ADediting_356945chr12_55834295_+ENSG00000182796.14ENST00000637092.1TMEM198B-213hsa-miR-5586-3pchr1255834293558342997mer-m85583353455834300146-14.33
ADediting_356945chr12_55834295_+ENSG00000182796.14ENST00000637092.1TMEM198B-213hsa-miR-6864-3pchr1255834289558342957mer-m85583353255834296147-17.44
ADediting_356945chr12_55834295_+ENSG00000182796.14ENST00000637092.1TMEM198B-213hsa-miR-759chr1255834294558343007mer-m85583353855834301143-12.38
ADediting_356946chr12_55834303_+ENSG00000182796.14ENST00000636659.1TMEM198B-210hsa-miR-1262chr1255834301558343077mer-m85583428655834308144-16.78
ADediting_356946chr12_55834303_+ENSG00000182796.14ENST00000636659.1TMEM198B-210hsa-miR-6736-5pchr1255834301558343077mer-m85583428855834308143-16.1
ADediting_356946chr12_55834303_+ENSG00000182796.14ENST00000637092.1TMEM198B-213hsa-miR-1262chr1255834301558343077mer-m85583428655834308144-16.78
ADediting_356946chr12_55834303_+ENSG00000182796.14ENST00000637092.1TMEM198B-213hsa-miR-6736-5pchr1255834301558343077mer-m85583428855834308143-16.1
ADediting_356949chr12_55834338_+ENSG00000182796.14ENST00000636659.1TMEM198B-210hsa-miR-6807-5pchr1255834332558343387mer-m85583431855834339148-19.37

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TMEM198B

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000478241.6lncRNASoverviewSoverview
ENST00000636659.1lncRNASoverviewSoverview
ENST00000636428.1lncRNASoverviewSoverview
ENST00000482378.6lncRNASoverviewSoverview
ENST00000637092.1lncRNASoverviewSoverview
ENST00000508246.6lncRNASoverviewSoverview
ENST00000471276.5lncRNASoverviewSoverview
ENST00000487582.1lncRNASoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_1533254ENST00000478241.6chr12_55835061_+1741-1083.70-1082.90-1083.70
ADediting_356945ENST00000636659.1chr12_55834295_+570-244.30-244.00-247.40
ADediting_356946ENST00000636659.1chr12_55834303_+578-243.30-244.00-247.40
ADediting_356947ENST00000636659.1chr12_55834317_+592-244.00-244.00-247.40
ADediting_356948ENST00000636659.1chr12_55834325_+600-245.50-244.00-247.40
ADediting_356949ENST00000636659.1chr12_55834338_+613-243.60-244.00-247.40
ADediting_1533254ENST00000636428.1chr12_55835061_+711-338.70-339.40-338.70
ADediting_1533254ENST00000482378.6chr12_55835061_+1045-836.50-835.70-836.50
ADediting_356945ENST00000637092.1chr12_55834295_+524-211.40-211.10-212.50
ADediting_356946ENST00000637092.1chr12_55834303_+532-211.90-211.10-212.50
ADediting_356947ENST00000637092.1chr12_55834317_+546-212.00-211.10-212.50
ADediting_1533254ENST00000508246.6chr12_55835061_+1130-871.10-871.70-871.10
ADediting_1533254ENST00000471276.5chr12_55835061_+773-692.90-692.10-692.90
ADediting_1533254ENST00000487582.1chr12_55835061_+906-587.80-588.50-587.80

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Relation with ADAR for TMEM198B

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_356932chr12_55833904_+0.3517810489977160.05306230166656270.316368733387876-0.0570910265450112.42405722445985e-100.349619114918438
DLPFCADediting_356934chr12_55833914_+0.9427780033719460.004093276467850230.186630330342358-0.07520334592669785.6719643743337e-080.302314411334826
DLPFCADediting_356949chr12_55834338_+2.2882713892762e-050.2380126699499497.2238760728253e-080.3000137870130890.4868663235780550.0396350718079542
DLPFCADediting_356966chr12_55834507_+0.0006223093912663390.1932845652601270.0005950235766641120.1939590961484462.05178187277163e-080.311775129087185
TCXADediting_356966chr12_55834507_+0.496280797090642-0.0559752961445070.00824972326198441-0.2149625262707542.3171253697423e-060.374670826396279

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC1.51596180905984e-090.3346085096640521.67480346605458e-110.3701732638977637.34422779463835e-150.422619918493441
AC1.08469458612435e-330.6681186512360948.26768274348465e-160.4799543929904481.13692556756002e-400.716525810355155
PCC9.97818427562332e-050.277812736505660.001074959162542350.2348423061763529.75922088963613e-080.37410482471318
TCX0.06450085013770070.1513412740824630.000147104680939016-0.3050652232790341.21235319172047e-300.769687540453153
FP2.01923870831406e-050.3136180768852330.4835155717566460.05285228337253736.96523127421611e-230.651564556301758
IFG0.05262966695198620.391984736153690.1226689629549220.316937871539982.04359342856513e-060.795130579288336
PG0.04638627886463340.146250019020440.556949468650095-0.0433406155400243.25283224276834e-200.608379248414986
STG0.2227639089457730.1344364225030550.067375834327615-0.200549735606151.65119978902555e-120.676391244128957

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Relation with AD stages for TMEM198B

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
TCX0.0001678233502096130.357582111938577

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RelatedDrugs for TMEM198B

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM198B

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource