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Center for Computational Systems Medicine
Soverview

Gene summary

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RNA A-to-I events

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Differntial gene expression between RNA A-to-I edited versus non-edited samples

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Protein coding region RNA A-to-I editings

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The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

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Relation with ADAR

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Relation with AD stages

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Related drugs with this gene

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Related diseases with this gene


Gene summary for MPST

check button Gene summary
Gene informationGene symbol

MPST

Gene ID

4357

Gene namemercaptopyruvate sulfurtransferase
SynonymsMST|TST2|TUM1
Cytomap

22q12.3

Type of geneprotein-coding
Description3-mercaptopyruvate sulfurtransferasehuman liver rhodanesetRNA thiouridin modification protein 1testicular tissue protein Li 200
Modification date20200313
UniProtAcc

P25325,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for MPST

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_988903(37027006, +), ADediting_988904(37027027, +), ADediting_988905(37027030, +), ADediting_988906(37027033, +), ADediting_988907(37027052, +), ADediting_988908(37027053, +), ADediting_988909(37027057, +), ADediting_988910(37027070, +), ADediting_988911(37027082, +), ADediting_988912(37027092, +), ADediting_988913(37027127, +), ADediting_988914(37027130, +), ADediting_988915(37027133, +), ADediting_988916(37027136, +), ADediting_988917(37027181, +), ADediting_988918(37027187, +), ADediting_988919(37027192, +), ADediting_988920(37027215, +), ADediting_988921(37027227, +), ADediting_988922(37027229, +), ADediting_988923(37027456, +), ADediting_988924(37027467, +), ADediting_988925(37028128, +), ADediting_988926(37028137, +), ADediting_988927(37028143, +), ADediting_988928(37028145, +), ADediting_988929(37028175, +), ADediting_988930(37028181, +), ADediting_988931(37028191, +), ADediting_988932(37028195, +), ADediting_988933(37028199, +), ADediting_988934(37028250, +), ADediting_988935(37028255, +), ADediting_988936(37028269, +), ADediting_988937(37028271, +), ADediting_988938(37028277, +), ADediting_988939(37028323, +), ADediting_988940(37028357, +), ADediting_988941(37028368, +), ADediting_988942(37028371, +), ADediting_988943(37028372, +), ADediting_988944(37028373, +), ADediting_988945(37028380, +), ADediting_988946(37028390, +), ADediting_988947(37028423, +), ADediting_988948(37028436, +), ADediting_988949(37028451, +), ADediting_988950(37028471, +), ADediting_988951(37028474, +), ADediting_988952(37028513, +), ADediting_988953(37028571, +), ADediting_988954(37028641, +), ADediting_988955(37028657, +), ADediting_1570482(37027214, +), ADediting_1570483(37027452, +), ADediting_1570484(37028123, +), ADediting_1570485(37028163, +), ADediting_1570486(37028377, +), ADediting_1570487(37028382, +),

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RNA editing positional annotations for MPST using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_988903chr22_37027006_+intronic
ADediting_988904chr22_37027027_+intronic
ADediting_988905chr22_37027030_+intronic
ADediting_988906chr22_37027033_+intronic
ADediting_988907chr22_37027052_+intronic
ADediting_988908chr22_37027053_+intronic
ADediting_988909chr22_37027057_+intronic
ADediting_988910chr22_37027070_+intronic
ADediting_988911chr22_37027082_+intronic
ADediting_988912chr22_37027092_+intronic
ADediting_988913chr22_37027127_+intronic
ADediting_988914chr22_37027130_+intronic
ADediting_988915chr22_37027133_+intronic
ADediting_988916chr22_37027136_+intronic
ADediting_988917chr22_37027181_+intronic
ADediting_988918chr22_37027187_+intronic
ADediting_988919chr22_37027192_+intronic
ADediting_988920chr22_37027215_+intronic
ADediting_988921chr22_37027227_+intronic
ADediting_988922chr22_37027229_+intronic
ADediting_988923chr22_37027456_+intronic
ADediting_988924chr22_37027467_+intronic
ADediting_988925chr22_37028128_+intronic
ADediting_988926chr22_37028137_+intronic
ADediting_988927chr22_37028143_+intronic
ADediting_988928chr22_37028145_+intronic
ADediting_988929chr22_37028175_+intronic
ADediting_988930chr22_37028181_+intronic
ADediting_988931chr22_37028191_+intronic
ADediting_988932chr22_37028195_+intronic
ADediting_988933chr22_37028199_+intronic
ADediting_988934chr22_37028250_+intronic
ADediting_988935chr22_37028255_+intronic
ADediting_988936chr22_37028269_+intronic
ADediting_988937chr22_37028271_+intronic
ADediting_988938chr22_37028277_+intronic
ADediting_988939chr22_37028323_+intronic
ADediting_988940chr22_37028357_+intronic
ADediting_988941chr22_37028368_+intronic
ADediting_988942chr22_37028371_+intronic
ADediting_988943chr22_37028372_+intronic
ADediting_988944chr22_37028373_+intronic
ADediting_988945chr22_37028380_+intronic
ADediting_988946chr22_37028390_+intronic
ADediting_988947chr22_37028423_+intronic
ADediting_988948chr22_37028436_+intronic
ADediting_988949chr22_37028451_+intronic
ADediting_988950chr22_37028471_+intronic
ADediting_988951chr22_37028474_+intronic
ADediting_988952chr22_37028513_+intronic
ADediting_988953chr22_37028571_+intronic
ADediting_988954chr22_37028641_+intronic
ADediting_988955chr22_37028657_+intronic
ADediting_1570482chr22_37027214_+intronic
ADediting_1570483chr22_37027452_+intronic
ADediting_1570484chr22_37028123_+intronic
ADediting_1570485chr22_37028163_+intronic
ADediting_1570486chr22_37028377_+intronic
ADediting_1570487chr22_37028382_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_988903chr22_37027006_+SINEAluName=AluSp
ADediting_988904chr22_37027027_+SINEAluName=AluSp
ADediting_988905chr22_37027030_+SINEAluName=AluSp
ADediting_988906chr22_37027033_+SINEAluName=AluSp
ADediting_988907chr22_37027052_+SINEAluName=AluSp
ADediting_988908chr22_37027053_+SINEAluName=AluSp
ADediting_988909chr22_37027057_+SINEAluName=AluSp
ADediting_988910chr22_37027070_+SINEAluName=AluSp
ADediting_988911chr22_37027082_+SINEAluName=AluSp
ADediting_988912chr22_37027092_+SINEAluName=AluSp
ADediting_988913chr22_37027127_+SINEAluName=AluSp
ADediting_988914chr22_37027130_+SINEAluName=AluSp
ADediting_988915chr22_37027133_+SINEAluName=AluSp
ADediting_988916chr22_37027136_+SINEAluName=AluSp
ADediting_988917chr22_37027181_+SINEAluName=AluSp
ADediting_988918chr22_37027187_+SINEAluName=AluSp
ADediting_988919chr22_37027192_+SINEAluName=AluSp
ADediting_988920chr22_37027215_+SINEAluName=AluSp
ADediting_988921chr22_37027227_+SINEAluName=AluSp
ADediting_988922chr22_37027229_+SINEAluName=AluSp
ADediting_988923chr22_37027456_+SINEAluName=AluJo
ADediting_988924chr22_37027467_+SINEAluName=AluJo
ADediting_988925chr22_37028128_+SINEAluName=AluJb
ADediting_988926chr22_37028137_+SINEAluName=AluJb
ADediting_988927chr22_37028143_+SINEAluName=AluJb
ADediting_988928chr22_37028145_+SINEAluName=AluJb
ADediting_988929chr22_37028175_+SINEAluName=AluJb
ADediting_988930chr22_37028181_+SINEAluName=AluJb
ADediting_988931chr22_37028191_+SINEAluName=AluJb
ADediting_988932chr22_37028195_+SINEAluName=AluJb
ADediting_988933chr22_37028199_+SINEAluName=AluJb
ADediting_988934chr22_37028250_+SINEAluName=AluJb
ADediting_988935chr22_37028255_+SINEAluName=AluSq
ADediting_988936chr22_37028269_+SINEAluName=AluSq
ADediting_988937chr22_37028271_+SINEAluName=AluSq
ADediting_988938chr22_37028277_+SINEAluName=AluSq
ADediting_988939chr22_37028323_+SINEAluName=AluSq
ADediting_988940chr22_37028357_+SINEAluName=AluSq
ADediting_988941chr22_37028368_+SINEAluName=AluSq
ADediting_988942chr22_37028371_+SINEAluName=AluSq
ADediting_988943chr22_37028372_+SINEAluName=AluSq
ADediting_988944chr22_37028373_+SINEAluName=AluSq
ADediting_988945chr22_37028380_+SINEAluName=AluSq
ADediting_988946chr22_37028390_+SINEAluName=AluSq
ADediting_988947chr22_37028423_+SINEAluName=AluSq
ADediting_988948chr22_37028436_+SINEAluName=AluSq
ADediting_988949chr22_37028451_+SINEAluName=AluSq
ADediting_988950chr22_37028471_+SINEAluName=AluSq
ADediting_988951chr22_37028474_+SINEAluName=AluSq
ADediting_988952chr22_37028513_+SINEAluName=AluSq
ADediting_988953chr22_37028571_+SINEAluName=AluJb
ADediting_988954chr22_37028641_+SINEAluName=AluJb
ADediting_988955chr22_37028657_+SINEAluName=AluJb
ADediting_1570482chr22_37027214_+SINEAluName=AluSp
ADediting_1570483chr22_37027452_+SINEAluName=AluJo
ADediting_1570484chr22_37028123_+SINEAluName=AluJb
ADediting_1570485chr22_37028163_+SINEAluName=AluJb
ADediting_1570486chr22_37028377_+SINEAluName=AluSq
ADediting_1570487chr22_37028382_+SINEAluName=AluSq

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RNA A-to-I editing events in the alternative splicing sites for MPST

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESADediting_988918chr22_37027187_+37027186:370271945ss2eCAGGTAATC6.99CGGGTAATC4.59
ESADediting_988918chr22_37027187_+37027186:370271945ss2eCAGGTAATC6.99CGGGTAATC4.59
ESADediting_988918chr22_37027187_+37027186:370271945ss2eCAGGTAATC6.99CGGGTAATC4.59
ESADediting_988918chr22_37027187_+37027186:370271945ss2eCAGGTAATC6.99CGGGTAATC4.59
ESADediting_988918chr22_37027187_+37027186:370271945ss2eCAGGTAATC6.99CGGGTAATC4.59
ESADediting_988919chr22_37027192_+37027186:370271945ss4iCAGGTAATC6.99CAGGTAGTC5.30
ESADediting_988919chr22_37027192_+37027186:370271945ss4iCAGGTAATC6.99CAGGTAGTC5.30

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MPST

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for MPST

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for MPST


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_286380chr11_79422188_-ENSG00000128309.16ENST00000404393.5MPST-204hsa-miR-5579-3pchr2237029342370293487mer-m83702932837029349154-14.08

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for MPST

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for MPST

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_988914chr22_37027130_+0.03890882639178430.117361108417880.3643705933827130.05169240030621349.4766807479899e-090.31874623833094
DLPFCADediting_988916chr22_37027136_+0.1330490028632730.08550755004800550.407248581001722-0.04723410317144154.96319082376475e-090.324448931251991
TCXADediting_988923chr22_37027456_+0.2640790970788030.09176157907706110.130218631432372-0.1241155827941791.35369703124987e-050.347073056277214
CERADediting_988927chr22_37028143_+0.1966270165851980.106017261676120.007671587530350870.216910084878233.18101167901306e-060.369901017091143
TCXADediting_988927chr22_37028143_+0.893738036450993-0.0109980913764230.0131651871542767-0.2020296364067014.05800731828082e-050.328502609395958
DLPFCADediting_988934chr22_37028250_+0.0134271889661530.1402851030801930.4576037094654440.04234023930582551.78732307573505e-080.313033672095293
TCXADediting_988936chr22_37028269_+0.7978411242087290.02108799880691260.012878747927289-0.2026548473986724.16829914159971e-050.328033761391461
CERADediting_988937chr22_37028271_+0.1448932425691910.1196024239541750.02330267183044770.1851613496539197.85111592192273e-070.390415043202025
TCXADediting_988937chr22_37028271_+0.27413123955565-0.08986287279177640.000195297258473183-0.2996349550945692.23665749760236e-090.463953897439434
DLPFCADediting_988939chr22_37028323_+0.2188335152424090.07003576281472620.8626751771996750.009863631377406359.69209355777804e-100.338345950623557
TCXADediting_988939chr22_37028323_+0.6481581406700440.03755962171340970.195296021552867-0.106331502183091.07991562105514e-050.350752790026557
DLPFCADediting_988946chr22_37028390_+0.005932552680974140.1559466916832250.5157865821170650.03704620836935941.18545364537262e-160.447257648966088
DLPFCADediting_988947chr22_37028423_+0.6843158056987630.02318279404767770.183800870614718-0.07568767267114382.90462187215972e-130.398825394675821
TCXADediting_988954chr22_37028641_+0.2503221416207230.09444186851196210.292565011610628-0.08649961064687373.05703006272595e-050.333408816375189

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC0.07679333204676640.1006579098359510.1286274785188440.08649148299205781.12804650875496e-390.656977813144406
AC8.10328786519055e-210.5458974067004571.71957349651674e-140.4599439786855791.25958555675409e-370.696579682874319
PCC0.4694292348103710.05265327641820220.6242050619943730.03567074786755151.2854826265509e-090.421303856020379
CER0.00268729305828763-0.2434039729552320.442090491362577-0.06322756604526932.29798106227169e-130.552520456838314
TCX0.190882812325474-0.1073846981654021.03084816997121e-10-0.4965499198598012.52611563122996e-270.740479110029424
FP2.75716801698672e-050.3087166213947130.0001386585856142250.2817882989615761.79968291317572e-210.634858398478091
IFG0.07096742353671380.3672007637837850.07877935313242530.3581296720915240.0002617399556028580.668200923233521
PG0.000168523916910869-0.2724471261617763.47224884758387e-06-0.3327680773003664.49511317451648e-230.642873851847665
STG0.00253873174198040.3252349049934540.475986042776040.07882997699008421.26408472857359e-120.678955932510542

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Relation with AD stages for MPST

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
TCX0.0004183257060860820.336626531775511
PG6.19326356449611e-060.324570763483717

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RelatedDrugs for MPST

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MPST

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
MPSTC0025202melanoma1CTD_human