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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for MMP17 |
 Gene summary |
| Gene information | Gene symbol | MMP17 | Gene ID | 4326 |
| Gene name | matrix metallopeptidase 17 | |
| Synonyms | MMP-17|MT4-MMP|MT4MMP|MTMMP4 | |
| Cytomap | 12q24.33 | |
| Type of gene | protein-coding | |
| Description | matrix metalloproteinase-17MT-MMP 4matrix metallopeptidase 17 (membrane-inserted)matrix metalloproteinase 17 (membrane-inserted)membrane-type matrix metalloproteinase 4membrane-type-4 matrix metalloproteinase | |
| Modification date | 20200313 | |
| UniProtAcc | Q9ULZ9, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for MMP17 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_329646(131839412, +), ADediting_329647(131839413, +), ADediting_329648(131839416, +), ADediting_329649(131839501, +), ADediting_329650(131839573, +), ADediting_329651(131839574, +), ADediting_329652(131839578, +), ADediting_329653(131839613, +), ADediting_329654(131839715, +), ADediting_329655(131839809, +), ADediting_329656(131839827, +), ADediting_329657(131839828, +), ADediting_329658(131839854, +), ADediting_329659(131839863, +), ADediting_329660(131839892, +), ADediting_329661(131839893, +), ADediting_329662(131840035, +), ADediting_329663(131840062, +), ADediting_329664(131840065, +), ADediting_329665(131842512, +), ADediting_329666(131843051, +), ADediting_329667(131843385, +), ADediting_329668(131846396, +), ADediting_329669(131846400, +), ADediting_329670(131846401, +), ADediting_329671(131846402, +), ADediting_329672(131846408, +), ADediting_329673(131846428, +), ADediting_329674(131846433, +), ADediting_329675(131846441, +), ADediting_329676(131846446, +), ADediting_329677(131846457, +), ADediting_329678(131846478, +), ADediting_329679(131846503, +), ADediting_329680(131846513, +), ADediting_329681(131846555, +), ADediting_329682(131846564, +), ADediting_329683(131846572, +), ADediting_329684(131846575, +), ADediting_329685(131846609, +), ADediting_329686(131846636, +), ADediting_329687(131846637, +), ADediting_329688(131846643, +), ADediting_329689(131846644, +), ADediting_329690(131846649, +), ADediting_329691(131846989, +), ADediting_329692(131847002, +), ADediting_329693(131847019, +), ADediting_329694(131847098, +), ADediting_329695(131847157, +), ADediting_329696(131847158, +), ADediting_329697(131847163, +), ADediting_329698(131847188, +), ADediting_329699(131847201, +), ADediting_329700(131847205, +), ADediting_329701(131847206, +), ADediting_329702(131847225, +), ADediting_329703(131847227, +), ADediting_329704(131847233, +), ADediting_329705(131847235, +), ADediting_329706(131847254, +), ADediting_329707(131847256, +), ADediting_329708(131847259, +), ADediting_329709(131847260, +), ADediting_329710(131847261, +), ADediting_329711(131847262, +), ADediting_329712(131847263, +), ADediting_329713(131847286, +), ADediting_329714(131847298, +), ADediting_329715(131847302, +), ADediting_329716(131847319, +), ADediting_329717(131847341, +), ADediting_329718(131847354, +), ADediting_329719(131847358, +), ADediting_329720(131847363, +), ADediting_329721(131847378, +), ADediting_329722(131847395, +), ADediting_329723(131847513, +), ADediting_329724(131848105, +), ADediting_329725(131848109, +), ADediting_329726(131848117, +), ADediting_329727(131848125, +), ADediting_329728(131848129, +), ADediting_329729(131848141, +), ADediting_329730(131848150, +), ADediting_329731(131848155, +), ADediting_329732(131848160, +), ADediting_329733(131848172, +), ADediting_329734(131848186, +), ADediting_329735(131848215, +), ADediting_329736(131848220, +), ADediting_329737(131848225, +), ADediting_329738(131848235, +), ADediting_329739(131848270, +), ADediting_329740(131848276, +), ADediting_329741(131848347, +), ADediting_329742(131848348, +), ADediting_329743(131848360, +), ADediting_329744(131849222, +), ADediting_329745(131849228, +), ADediting_329746(131849234, +), ADediting_329747(131849274, +), ADediting_329748(131849364, +), ADediting_329749(131849429, +), ADediting_329750(131849470, +), ADediting_329751(131849471, +), ADediting_1531644(131839336, +), ADediting_1531645(131839538, +), ADediting_1531646(131839551, +), ADediting_1531647(131839554, +), ADediting_1531648(131849380, +), |
Top |
RNA editing positional annotations for MMP17 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_329646 | chr12_131839412_+ | intronic |
| ADediting_329647 | chr12_131839413_+ | intronic |
| ADediting_329648 | chr12_131839416_+ | intronic |
| ADediting_329649 | chr12_131839501_+ | intronic |
| ADediting_329650 | chr12_131839573_+ | intronic |
| ADediting_329651 | chr12_131839574_+ | intronic |
| ADediting_329652 | chr12_131839578_+ | intronic |
| ADediting_329653 | chr12_131839613_+ | intronic |
| ADediting_329654 | chr12_131839715_+ | intronic |
| ADediting_329655 | chr12_131839809_+ | intronic |
| ADediting_329656 | chr12_131839827_+ | intronic |
| ADediting_329657 | chr12_131839828_+ | intronic |
| ADediting_329658 | chr12_131839854_+ | intronic |
| ADediting_329659 | chr12_131839863_+ | intronic |
| ADediting_329660 | chr12_131839892_+ | intronic |
| ADediting_329661 | chr12_131839893_+ | intronic |
| ADediting_329662 | chr12_131840035_+ | UTR5 |
| ADediting_329663 | chr12_131840062_+ | UTR5 |
| ADediting_329664 | chr12_131840065_+ | UTR5 |
| ADediting_329665 | chr12_131842512_+ | intronic |
| ADediting_329666 | chr12_131843051_+ | intronic |
| ADediting_329667 | chr12_131843385_+ | intronic |
| ADediting_329668 | chr12_131846396_+ | intronic |
| ADediting_329669 | chr12_131846400_+ | intronic |
| ADediting_329670 | chr12_131846401_+ | intronic |
| ADediting_329671 | chr12_131846402_+ | intronic |
| ADediting_329672 | chr12_131846408_+ | intronic |
| ADediting_329673 | chr12_131846428_+ | intronic |
| ADediting_329674 | chr12_131846433_+ | intronic |
| ADediting_329675 | chr12_131846441_+ | intronic |
| ADediting_329676 | chr12_131846446_+ | intronic |
| ADediting_329677 | chr12_131846457_+ | intronic |
| ADediting_329678 | chr12_131846478_+ | intronic |
| ADediting_329679 | chr12_131846503_+ | intronic |
| ADediting_329680 | chr12_131846513_+ | intronic |
| ADediting_329681 | chr12_131846555_+ | intronic |
| ADediting_329682 | chr12_131846564_+ | intronic |
| ADediting_329683 | chr12_131846572_+ | intronic |
| ADediting_329684 | chr12_131846575_+ | intronic |
| ADediting_329685 | chr12_131846609_+ | intronic |
| ADediting_329686 | chr12_131846636_+ | intronic |
| ADediting_329687 | chr12_131846637_+ | intronic |
| ADediting_329688 | chr12_131846643_+ | intronic |
| ADediting_329689 | chr12_131846644_+ | intronic |
| ADediting_329690 | chr12_131846649_+ | intronic |
| ADediting_329691 | chr12_131846989_+ | intronic |
| ADediting_329692 | chr12_131847002_+ | intronic |
| ADediting_329693 | chr12_131847019_+ | intronic |
| ADediting_329694 | chr12_131847098_+ | intronic |
| ADediting_329695 | chr12_131847157_+ | intronic |
| ADediting_329696 | chr12_131847158_+ | intronic |
| ADediting_329697 | chr12_131847163_+ | intronic |
| ADediting_329698 | chr12_131847188_+ | intronic |
| ADediting_329699 | chr12_131847201_+ | intronic |
| ADediting_329700 | chr12_131847205_+ | intronic |
| ADediting_329701 | chr12_131847206_+ | intronic |
| ADediting_329702 | chr12_131847225_+ | intronic |
| ADediting_329703 | chr12_131847227_+ | intronic |
| ADediting_329704 | chr12_131847233_+ | intronic |
| ADediting_329705 | chr12_131847235_+ | intronic |
| ADediting_329706 | chr12_131847254_+ | intronic |
| ADediting_329707 | chr12_131847256_+ | intronic |
| ADediting_329708 | chr12_131847259_+ | intronic |
| ADediting_329709 | chr12_131847260_+ | intronic |
| ADediting_329710 | chr12_131847261_+ | intronic |
| ADediting_329711 | chr12_131847262_+ | intronic |
| ADediting_329712 | chr12_131847263_+ | intronic |
| ADediting_329713 | chr12_131847286_+ | intronic |
| ADediting_329714 | chr12_131847298_+ | intronic |
| ADediting_329715 | chr12_131847302_+ | intronic |
| ADediting_329716 | chr12_131847319_+ | intronic |
| ADediting_329717 | chr12_131847341_+ | intronic |
| ADediting_329718 | chr12_131847354_+ | intronic |
| ADediting_329719 | chr12_131847358_+ | intronic |
| ADediting_329720 | chr12_131847363_+ | intronic |
| ADediting_329721 | chr12_131847378_+ | intronic |
| ADediting_329722 | chr12_131847395_+ | intronic |
| ADediting_329723 | chr12_131847513_+ | intronic |
| ADediting_329724 | chr12_131848105_+ | intronic |
| ADediting_329725 | chr12_131848109_+ | intronic |
| ADediting_329726 | chr12_131848117_+ | intronic |
| ADediting_329727 | chr12_131848125_+ | intronic |
| ADediting_329728 | chr12_131848129_+ | intronic |
| ADediting_329729 | chr12_131848141_+ | intronic |
| ADediting_329730 | chr12_131848150_+ | intronic |
| ADediting_329731 | chr12_131848155_+ | intronic |
| ADediting_329732 | chr12_131848160_+ | intronic |
| ADediting_329733 | chr12_131848172_+ | intronic |
| ADediting_329734 | chr12_131848186_+ | intronic |
| ADediting_329735 | chr12_131848215_+ | intronic |
| ADediting_329736 | chr12_131848220_+ | intronic |
| ADediting_329737 | chr12_131848225_+ | intronic |
| ADediting_329738 | chr12_131848235_+ | intronic |
| ADediting_329739 | chr12_131848270_+ | intronic |
| ADediting_329740 | chr12_131848276_+ | intronic |
| ADediting_329741 | chr12_131848347_+ | intronic |
| ADediting_329742 | chr12_131848348_+ | intronic |
| ADediting_329743 | chr12_131848360_+ | intronic |
| ADediting_329744 | chr12_131849222_+ | intronic |
| ADediting_329745 | chr12_131849228_+ | intronic |
| ADediting_329746 | chr12_131849234_+ | intronic |
| ADediting_329747 | chr12_131849274_+ | intronic |
| ADediting_329748 | chr12_131849364_+ | intronic |
| ADediting_329749 | chr12_131849429_+ | intronic |
| ADediting_329750 | chr12_131849470_+ | intronic |
| ADediting_329751 | chr12_131849471_+ | intronic |
| ADediting_1531644 | chr12_131839336_+ | intronic |
| ADediting_1531645 | chr12_131839538_+ | intronic |
| ADediting_1531646 | chr12_131839551_+ | intronic |
| ADediting_1531647 | chr12_131839554_+ | intronic |
| ADediting_1531648 | chr12_131849380_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_329646 | chr12_131839412_+ | SINE | Alu | Name=AluJo |
| ADediting_329647 | chr12_131839413_+ | SINE | Alu | Name=AluJo |
| ADediting_329648 | chr12_131839416_+ | SINE | Alu | Name=AluJo |
| ADediting_329649 | chr12_131839501_+ | SINE | Alu | Name=AluJo |
| ADediting_329650 | chr12_131839573_+ | SINE | Alu | Name=AluJo |
| ADediting_329651 | chr12_131839574_+ | SINE | Alu | Name=AluJo |
| ADediting_329652 | chr12_131839578_+ | SINE | Alu | Name=AluJo |
| ADediting_329653 | chr12_131839613_+ | SINE | Alu | Name=AluJo |
| ADediting_329654 | chr12_131839715_+ | SINE | Alu | Name=AluSz |
| ADediting_329655 | chr12_131839809_+ | SINE | Alu | Name=AluSz |
| ADediting_329656 | chr12_131839827_+ | SINE | Alu | Name=AluSz |
| ADediting_329657 | chr12_131839828_+ | SINE | Alu | Name=AluSz |
| ADediting_329658 | chr12_131839854_+ | SINE | Alu | Name=AluSz |
| ADediting_329659 | chr12_131839863_+ | SINE | Alu | Name=AluSz |
| ADediting_329660 | chr12_131839892_+ | SINE | Alu | Name=AluSz |
| ADediting_329661 | chr12_131839893_+ | SINE | Alu | Name=AluSz |
| ADediting_329662 | chr12_131840035_+ | SINE | Alu | Name=AluSz6 |
| ADediting_329663 | chr12_131840062_+ | SINE | Alu | Name=AluSz6 |
| ADediting_329664 | chr12_131840065_+ | SINE | Alu | Name=AluSz6 |
| ADediting_329665 | chr12_131842512_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329666 | chr12_131843051_+ | SINE | Alu | Name=AluY |
| ADediting_329667 | chr12_131843385_+ | SINE | Alu | Name=AluJo |
| ADediting_329668 | chr12_131846396_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329669 | chr12_131846400_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329670 | chr12_131846401_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329671 | chr12_131846402_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329672 | chr12_131846408_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329673 | chr12_131846428_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329674 | chr12_131846433_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329675 | chr12_131846441_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329676 | chr12_131846446_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329677 | chr12_131846457_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329678 | chr12_131846478_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329679 | chr12_131846503_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329680 | chr12_131846513_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329681 | chr12_131846555_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329682 | chr12_131846564_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329683 | chr12_131846572_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329684 | chr12_131846575_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329685 | chr12_131846609_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329686 | chr12_131846636_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329687 | chr12_131846637_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329688 | chr12_131846643_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329689 | chr12_131846644_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329690 | chr12_131846649_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329692 | chr12_131847002_+ | SINE | Alu | Name=AluJb |
| ADediting_329693 | chr12_131847019_+ | SINE | Alu | Name=AluJb |
| ADediting_329694 | chr12_131847098_+ | SINE | Alu | Name=AluJb |
| ADediting_329695 | chr12_131847157_+ | SINE | Alu | Name=AluY |
| ADediting_329696 | chr12_131847158_+ | SINE | Alu | Name=AluY |
| ADediting_329697 | chr12_131847163_+ | SINE | Alu | Name=AluY |
| ADediting_329698 | chr12_131847188_+ | SINE | Alu | Name=AluY |
| ADediting_329699 | chr12_131847201_+ | SINE | Alu | Name=AluY |
| ADediting_329700 | chr12_131847205_+ | SINE | Alu | Name=AluY |
| ADediting_329701 | chr12_131847206_+ | SINE | Alu | Name=AluY |
| ADediting_329702 | chr12_131847225_+ | SINE | Alu | Name=AluY |
| ADediting_329703 | chr12_131847227_+ | SINE | Alu | Name=AluY |
| ADediting_329704 | chr12_131847233_+ | SINE | Alu | Name=AluY |
| ADediting_329705 | chr12_131847235_+ | SINE | Alu | Name=AluY |
| ADediting_329706 | chr12_131847254_+ | SINE | Alu | Name=AluY |
| ADediting_329707 | chr12_131847256_+ | SINE | Alu | Name=AluY |
| ADediting_329708 | chr12_131847259_+ | SINE | Alu | Name=AluY |
| ADediting_329709 | chr12_131847260_+ | SINE | Alu | Name=AluY |
| ADediting_329710 | chr12_131847261_+ | SINE | Alu | Name=AluY |
| ADediting_329711 | chr12_131847262_+ | SINE | Alu | Name=AluY |
| ADediting_329712 | chr12_131847263_+ | SINE | Alu | Name=AluY |
| ADediting_329713 | chr12_131847286_+ | SINE | Alu | Name=AluY |
| ADediting_329714 | chr12_131847298_+ | SINE | Alu | Name=AluY |
| ADediting_329715 | chr12_131847302_+ | SINE | Alu | Name=AluY |
| ADediting_329716 | chr12_131847319_+ | SINE | Alu | Name=AluY |
| ADediting_329717 | chr12_131847341_+ | SINE | Alu | Name=AluY |
| ADediting_329718 | chr12_131847354_+ | SINE | Alu | Name=AluY |
| ADediting_329719 | chr12_131847358_+ | SINE | Alu | Name=AluY |
| ADediting_329720 | chr12_131847363_+ | SINE | Alu | Name=AluY |
| ADediting_329721 | chr12_131847378_+ | SINE | Alu | Name=AluY |
| ADediting_329722 | chr12_131847395_+ | SINE | Alu | Name=AluY |
| ADediting_329724 | chr12_131848105_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329725 | chr12_131848109_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329726 | chr12_131848117_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329727 | chr12_131848125_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329728 | chr12_131848129_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329729 | chr12_131848141_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329730 | chr12_131848150_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329731 | chr12_131848155_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329732 | chr12_131848160_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329733 | chr12_131848172_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329734 | chr12_131848186_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329735 | chr12_131848215_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329736 | chr12_131848220_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329737 | chr12_131848225_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329738 | chr12_131848235_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329739 | chr12_131848270_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329740 | chr12_131848276_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329741 | chr12_131848347_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329742 | chr12_131848348_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329743 | chr12_131848360_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329744 | chr12_131849222_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329745 | chr12_131849228_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329746 | chr12_131849234_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329747 | chr12_131849274_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329748 | chr12_131849364_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329749 | chr12_131849429_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329750 | chr12_131849470_+ | SINE | Alu | Name=AluSx1 |
| ADediting_329751 | chr12_131849471_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1531644 | chr12_131839336_+ | SINE | Alu | Name=AluJo |
| ADediting_1531645 | chr12_131839538_+ | SINE | Alu | Name=AluJo |
| ADediting_1531646 | chr12_131839551_+ | SINE | Alu | Name=AluJo |
| ADediting_1531647 | chr12_131839554_+ | SINE | Alu | Name=AluJo |
| ADediting_1531648 | chr12_131849380_+ | SINE | Alu | Name=AluSx1 |
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RNA A-to-I editing events in the alternative splicing sites for MMP17 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| ES | ADediting_1531644 | chr12_131839336_+ | 131839314:131839336 | 3ss | 3e | TTTCTTTTTTTTTTTTTGAGACA | 2.14 | TTTCTTTTTTTTTTTTTGAGACG | 3.80 |
| ES | ADediting_1531644 | chr12_131839336_+ | 131839318:131839340 | 3ss | 2i | TTTTTTTTTTTTTGAGACAGGGT | 4.19 | TTTTTTTTTTTTTGAGACGGGGT | -3.77 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MMP17 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for MMP17 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for MMP17 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for MMP17 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000534865.1 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_329662 | ENST00000534865.1 | chr12_131840035_+ | 11 | -651.80 | -652.10 | -657.80 |
| ADediting_329663 | ENST00000534865.1 | chr12_131840062_+ | 38 | -654.50 | -652.10 | -657.80 |
| ADediting_329664 | ENST00000534865.1 | chr12_131840065_+ | 41 | -654.50 | -652.10 | -657.80 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for MMP17 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| TCX | ADediting_329672 | chr12_131846408_+ | 8.88921532858096e-05 | 0.314464696634416 | 3.34012068531888e-05 | 0.331883745619816 | 0.0698576228141368 | -0.148437819311536 |
| TCX | ADediting_329686 | chr12_131846636_+ | 0.000473817198333895 | 0.281924083045407 | 0.000118063346774234 | 0.309207787748218 | 0.0524017883958677 | -0.158707807733811 |
| TCX | ADediting_329689 | chr12_131846644_+ | 0.000230270406737584 | 0.296428637367795 | 0.000179622411139924 | 0.301249290733433 | 0.147335155909561 | -0.118885582125755 |
| TCX | ADediting_329690 | chr12_131846649_+ | 6.87394430868667e-05 | 0.319144044573561 | 0.000164302685680108 | 0.302959099187647 | 0.444176568183438 | -0.0629395544491342 |
| TCX | ADediting_329699 | chr12_131847201_+ | 0.0035329956748651 | 0.236764935923948 | 0.000160811206594144 | 0.30336949897064 | 0.156888711945177 | -0.116164431652041 |
| TCX | ADediting_329700 | chr12_131847205_+ | 0.0282745851410417 | 0.179142118473796 | 1.69554601019789e-05 | 0.343359702754417 | 0.00854229022647681 | -0.21402263646656 |
| TCX | ADediting_329723 | chr12_131847513_+ | 7.23276716255913e-05 | 0.318224050330971 | 0.00341406841967701 | 0.237605557387361 | 0.4591230331626 | -0.0608978701370567 |
| TCX | ADediting_329725 | chr12_131848109_+ | 0.00112212814648121 | 0.263499096172669 | 8.80058484988539e-05 | 0.314648532281895 | 0.0501177138650206 | -0.160253546917789 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 8.04985800598602e-13 | 0.391879842745814 | 1.58403084376932e-23 | 0.526715274333029 | 4.15373054232455e-05 | 0.230580786855179 |
| AC | 1.17744012258887e-26 | 0.607937482149205 | 1.49234914297768e-38 | 0.702827667743015 | 4.30402606452781e-07 | 0.313195799739194 |
| PCC | 1.12100426646118e-26 | 0.674256041875461 | 8.4350668657903e-33 | 0.727902622006159 | 0.0753694778557436 | 0.128975409008329 |
| TCX | 0.132049016477478 | 0.123532060120986 | 2.60250188951269e-06 | 0.37293129560504 | 0.000187996520848611 | -0.300371249998287 |
| FP | 2.77024213711889e-11 | 0.47245730195578 | 0.00019150909503899 | 0.27606463909502 | 3.36098967163935e-06 | 0.340284626227728 |
| IFG | 1.94369182746468e-06 | 0.796113784592436 | 1.38998298547317e-09 | 0.896171991861252 | 0.118347517431983 | 0.320452967658086 |
| STG | 9.49606946519075e-10 | 0.606749534310592 | 1.07133050660138e-07 | 0.541110619242293 | 0.719263534443475 | -0.0397992747343818 |
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Relation with AD stages for MMP17 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| IFG | ADediting_329672 | chr12_131846408_+ | 0.0354713369979928 | 0.422303326441651 |
| IFG | ADediting_329673 | chr12_131846428_+ | 0.0353488225216572 | 0.42255826357712 |
| IFG | ADediting_329674 | chr12_131846433_+ | 0.0354713369979928 | 0.422303326441651 |
| IFG | ADediting_329678 | chr12_131846478_+ | 0.0354713369979928 | 0.422303326441651 |
| IFG | ADediting_329680 | chr12_131846513_+ | 0.0354713369979928 | 0.422303326441651 |
| IFG | ADediting_329681 | chr12_131846555_+ | 0.0113059937049014 | 0.497952103823781 |
| IFG | ADediting_329687 | chr12_131846637_+ | 0.0354713369979928 | 0.422303326441651 |
| IFG | ADediting_329689 | chr12_131846644_+ | 0.0354713369979928 | 0.422303326441651 |
| IFG | ADediting_329690 | chr12_131846649_+ | 0.0354713369979928 | 0.422303326441651 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for MMP17 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MMP17 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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