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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for LRP4 |
 Gene summary |
| Gene information | Gene symbol | LRP4 | Gene ID | 4038 |
| Gene name | LDL receptor related protein 4 | |
| Synonyms | CLSS|CMS17|LRP-4|LRP10|MEGF7|SOST2 | |
| Cytomap | 11p11.2 | |
| Type of gene | protein-coding | |
| Description | low-density lipoprotein receptor-related protein 4multiple epidermal growth factor-like domains 7 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| LRP4 | GO:0001822 | kidney development | 20381006 |
| LRP4 | GO:0060173 | limb development | 20381006 |
| LRP4 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 20093106 |
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RNA A-to-I events for LRP4 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_254716(46884347, -), ADediting_254717(46884359, -), ADediting_254718(46884779, -), ADediting_254719(46884811, -), ADediting_254720(46884827, -), ADediting_254721(46885028, -), ADediting_254722(46885100, -), ADediting_254723(46885124, -), ADediting_254724(46885139, -), ADediting_254725(46885140, -), ADediting_254726(46885219, -), ADediting_254727(46885272, -), ADediting_254728(46885276, -), ADediting_254729(46885529, -), ADediting_254730(46885539, -), ADediting_254731(46901914, -), ADediting_254732(46903321, -), ADediting_254733(46903325, -), ADediting_254734(46904919, -), ADediting_254735(46908007, -), ADediting_254736(46908008, -), ADediting_254737(46908043, -), ADediting_254738(46908056, -), ADediting_254739(46908060, -), ADediting_254740(46908202, -), ADediting_254741(46908203, -), ADediting_254742(46908219, -), ADediting_254743(46909350, -), ADediting_254744(46909362, -), ADediting_254745(46910746, -), ADediting_254746(46910747, -), ADediting_254747(46910756, -), ADediting_254748(46910770, -), ADediting_254749(46911532, -), ADediting_254750(46911537, -), ADediting_254751(46911570, -), ADediting_254752(46911910, -), ADediting_254753(46911915, -), ADediting_254754(46911939, -), ADediting_254755(46911995, -), ADediting_254756(46912018, -), ADediting_254757(46912057, -), ADediting_254758(46912135, -), ADediting_254759(46912149, -), ADediting_254760(46915606, -), ADediting_254761(46915611, -), ADediting_254762(46915612, -), ADediting_254763(46915619, -), ADediting_254764(46915620, -), ADediting_254765(46915626, -), ADediting_254766(46915692, -), ADediting_254767(46915698, -), ADediting_254768(46915704, -), ADediting_254769(46915708, -), ADediting_254770(46915712, -), ADediting_254771(46915713, -), ADediting_254772(46915737, -), ADediting_254773(46915738, -), ADediting_254774(46915739, -), ADediting_254775(46915740, -), ADediting_254776(46915747, -), ADediting_254777(46915757, -), ADediting_254778(46915789, -), ADediting_254779(46916242, -), ADediting_254780(46916259, -), ADediting_254781(46916295, -), ADediting_254782(46916302, -), ADediting_254783(46916308, -), ADediting_254784(46916327, -), ADediting_254785(46916328, -), ADediting_254786(46916371, -), ADediting_254787(46916378, -), ADediting_254788(46916380, -), ADediting_254789(46916388, -), ADediting_254790(46916394, -), ADediting_254791(46916406, -), ADediting_254792(46916877, -), |
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RNA editing positional annotations for LRP4 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_254716 | chr11_46884347_- | intronic |
| ADediting_254717 | chr11_46884359_- | intronic |
| ADediting_254718 | chr11_46884779_- | intronic |
| ADediting_254719 | chr11_46884811_- | intronic |
| ADediting_254720 | chr11_46884827_- | intronic |
| ADediting_254721 | chr11_46885028_- | intronic |
| ADediting_254722 | chr11_46885100_- | intronic |
| ADediting_254723 | chr11_46885124_- | intronic |
| ADediting_254724 | chr11_46885139_- | intronic |
| ADediting_254725 | chr11_46885140_- | intronic |
| ADediting_254726 | chr11_46885219_- | intronic |
| ADediting_254727 | chr11_46885272_- | intronic |
| ADediting_254728 | chr11_46885276_- | intronic |
| ADediting_254729 | chr11_46885529_- | intronic |
| ADediting_254730 | chr11_46885539_- | intronic |
| ADediting_254731 | chr11_46901914_- | intronic |
| ADediting_254732 | chr11_46903321_- | intronic |
| ADediting_254733 | chr11_46903325_- | intronic |
| ADediting_254734 | chr11_46904919_- | intronic |
| ADediting_254735 | chr11_46908007_- | intronic |
| ADediting_254736 | chr11_46908008_- | intronic |
| ADediting_254737 | chr11_46908043_- | intronic |
| ADediting_254738 | chr11_46908056_- | intronic |
| ADediting_254739 | chr11_46908060_- | intronic |
| ADediting_254740 | chr11_46908202_- | intronic |
| ADediting_254741 | chr11_46908203_- | intronic |
| ADediting_254742 | chr11_46908219_- | intronic |
| ADediting_254743 | chr11_46909350_- | intronic |
| ADediting_254744 | chr11_46909362_- | intronic |
| ADediting_254745 | chr11_46910746_- | intronic |
| ADediting_254746 | chr11_46910747_- | intronic |
| ADediting_254747 | chr11_46910756_- | intronic |
| ADediting_254748 | chr11_46910770_- | intronic |
| ADediting_254749 | chr11_46911532_- | intronic |
| ADediting_254750 | chr11_46911537_- | intronic |
| ADediting_254751 | chr11_46911570_- | intronic |
| ADediting_254752 | chr11_46911910_- | intronic |
| ADediting_254753 | chr11_46911915_- | intronic |
| ADediting_254754 | chr11_46911939_- | intronic |
| ADediting_254755 | chr11_46911995_- | intronic |
| ADediting_254756 | chr11_46912018_- | intronic |
| ADediting_254757 | chr11_46912057_- | intronic |
| ADediting_254758 | chr11_46912135_- | intronic |
| ADediting_254759 | chr11_46912149_- | intronic |
| ADediting_254760 | chr11_46915606_- | intronic |
| ADediting_254761 | chr11_46915611_- | intronic |
| ADediting_254762 | chr11_46915612_- | intronic |
| ADediting_254763 | chr11_46915619_- | intronic |
| ADediting_254764 | chr11_46915620_- | intronic |
| ADediting_254765 | chr11_46915626_- | intronic |
| ADediting_254766 | chr11_46915692_- | intronic |
| ADediting_254767 | chr11_46915698_- | intronic |
| ADediting_254768 | chr11_46915704_- | intronic |
| ADediting_254769 | chr11_46915708_- | intronic |
| ADediting_254770 | chr11_46915712_- | intronic |
| ADediting_254771 | chr11_46915713_- | intronic |
| ADediting_254772 | chr11_46915737_- | intronic |
| ADediting_254773 | chr11_46915738_- | intronic |
| ADediting_254774 | chr11_46915739_- | intronic |
| ADediting_254775 | chr11_46915740_- | intronic |
| ADediting_254776 | chr11_46915747_- | intronic |
| ADediting_254777 | chr11_46915757_- | intronic |
| ADediting_254778 | chr11_46915789_- | intronic |
| ADediting_254779 | chr11_46916242_- | intronic |
| ADediting_254780 | chr11_46916259_- | intronic |
| ADediting_254781 | chr11_46916295_- | intronic |
| ADediting_254782 | chr11_46916302_- | intronic |
| ADediting_254783 | chr11_46916308_- | intronic |
| ADediting_254784 | chr11_46916327_- | intronic |
| ADediting_254785 | chr11_46916328_- | intronic |
| ADediting_254786 | chr11_46916371_- | intronic |
| ADediting_254787 | chr11_46916378_- | intronic |
| ADediting_254788 | chr11_46916380_- | intronic |
| ADediting_254789 | chr11_46916388_- | intronic |
| ADediting_254790 | chr11_46916394_- | intronic |
| ADediting_254791 | chr11_46916406_- | intronic |
| ADediting_254792 | chr11_46916877_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_254716 | chr11_46884347_- | SINE | Alu | Name=AluSg |
| ADediting_254717 | chr11_46884359_- | SINE | Alu | Name=AluSg |
| ADediting_254718 | chr11_46884779_- | SINE | Alu | Name=AluSg |
| ADediting_254719 | chr11_46884811_- | SINE | Alu | Name=AluSg |
| ADediting_254720 | chr11_46884827_- | SINE | Alu | Name=AluSg |
| ADediting_254721 | chr11_46885028_- | SINE | Alu | Name=AluJo |
| ADediting_254722 | chr11_46885100_- | SINE | Alu | Name=AluJo |
| ADediting_254723 | chr11_46885124_- | SINE | Alu | Name=AluJo |
| ADediting_254724 | chr11_46885139_- | SINE | Alu | Name=AluJo |
| ADediting_254725 | chr11_46885140_- | SINE | Alu | Name=AluJo |
| ADediting_254726 | chr11_46885219_- | SINE | Alu | Name=AluJo |
| ADediting_254727 | chr11_46885272_- | SINE | Alu | Name=AluJo |
| ADediting_254728 | chr11_46885276_- | SINE | Alu | Name=AluJo |
| ADediting_254729 | chr11_46885529_- | SINE | Alu | Name=AluSc |
| ADediting_254730 | chr11_46885539_- | SINE | Alu | Name=AluSc |
| ADediting_254731 | chr11_46901914_- | SINE | Alu | Name=AluY |
| ADediting_254732 | chr11_46903321_- | SINE | Alu | Name=AluJo |
| ADediting_254733 | chr11_46903325_- | SINE | Alu | Name=AluJo |
| ADediting_254734 | chr11_46904919_- | SINE | Alu | Name=AluJb |
| ADediting_254735 | chr11_46908007_- | SINE | Alu | Name=AluSx1 |
| ADediting_254736 | chr11_46908008_- | SINE | Alu | Name=AluSx1 |
| ADediting_254737 | chr11_46908043_- | SINE | Alu | Name=AluSx1 |
| ADediting_254738 | chr11_46908056_- | SINE | Alu | Name=AluSx1 |
| ADediting_254739 | chr11_46908060_- | SINE | Alu | Name=AluSx1 |
| ADediting_254740 | chr11_46908202_- | SINE | Alu | Name=AluSx1 |
| ADediting_254741 | chr11_46908203_- | SINE | Alu | Name=AluSx1 |
| ADediting_254742 | chr11_46908219_- | SINE | Alu | Name=AluSx1 |
| ADediting_254743 | chr11_46909350_- | SINE | Alu | Name=AluYb8 |
| ADediting_254744 | chr11_46909362_- | SINE | Alu | Name=AluYb8 |
| ADediting_254745 | chr11_46910746_- | SINE | Alu | Name=AluSz |
| ADediting_254746 | chr11_46910747_- | SINE | Alu | Name=AluSz |
| ADediting_254747 | chr11_46910756_- | SINE | Alu | Name=AluSz |
| ADediting_254748 | chr11_46910770_- | SINE | Alu | Name=AluSz |
| ADediting_254749 | chr11_46911532_- | SINE | Alu | Name=AluJo |
| ADediting_254750 | chr11_46911537_- | SINE | Alu | Name=AluJo |
| ADediting_254751 | chr11_46911570_- | SINE | Alu | Name=AluJo |
| ADediting_254752 | chr11_46911910_- | SINE | Alu | Name=AluSz |
| ADediting_254753 | chr11_46911915_- | SINE | Alu | Name=AluSz |
| ADediting_254754 | chr11_46911939_- | SINE | Alu | Name=AluSz |
| ADediting_254755 | chr11_46911995_- | SINE | Alu | Name=AluSz |
| ADediting_254756 | chr11_46912018_- | SINE | Alu | Name=AluSz |
| ADediting_254757 | chr11_46912057_- | SINE | Alu | Name=AluSz |
| ADediting_254758 | chr11_46912135_- | SINE | Alu | Name=AluSz |
| ADediting_254759 | chr11_46912149_- | SINE | Alu | Name=AluSz |
| ADediting_254760 | chr11_46915606_- | SINE | Alu | Name=AluSz6 |
| ADediting_254761 | chr11_46915611_- | SINE | Alu | Name=AluSz6 |
| ADediting_254762 | chr11_46915612_- | SINE | Alu | Name=AluSz6 |
| ADediting_254763 | chr11_46915619_- | SINE | Alu | Name=AluSz6 |
| ADediting_254764 | chr11_46915620_- | SINE | Alu | Name=AluSz6 |
| ADediting_254765 | chr11_46915626_- | SINE | Alu | Name=AluSz6 |
| ADediting_254766 | chr11_46915692_- | SINE | Alu | Name=AluSz6 |
| ADediting_254767 | chr11_46915698_- | SINE | Alu | Name=AluSz6 |
| ADediting_254768 | chr11_46915704_- | SINE | Alu | Name=AluSz6 |
| ADediting_254769 | chr11_46915708_- | SINE | Alu | Name=AluSz6 |
| ADediting_254770 | chr11_46915712_- | SINE | Alu | Name=AluSz6 |
| ADediting_254771 | chr11_46915713_- | SINE | Alu | Name=AluSz6 |
| ADediting_254772 | chr11_46915737_- | SINE | Alu | Name=AluSz6 |
| ADediting_254773 | chr11_46915738_- | SINE | Alu | Name=AluSz6 |
| ADediting_254774 | chr11_46915739_- | SINE | Alu | Name=AluSz6 |
| ADediting_254775 | chr11_46915740_- | SINE | Alu | Name=AluSz6 |
| ADediting_254776 | chr11_46915747_- | SINE | Alu | Name=AluSz6 |
| ADediting_254777 | chr11_46915757_- | SINE | Alu | Name=AluSz6 |
| ADediting_254778 | chr11_46915789_- | SINE | Alu | Name=AluSz6 |
| ADediting_254779 | chr11_46916242_- | SINE | Alu | Name=AluJb |
| ADediting_254780 | chr11_46916259_- | SINE | Alu | Name=AluJb |
| ADediting_254781 | chr11_46916295_- | SINE | Alu | Name=AluJb |
| ADediting_254782 | chr11_46916302_- | SINE | Alu | Name=AluJb |
| ADediting_254783 | chr11_46916308_- | SINE | Alu | Name=AluJb |
| ADediting_254784 | chr11_46916327_- | SINE | Alu | Name=AluJb |
| ADediting_254785 | chr11_46916328_- | SINE | Alu | Name=AluJb |
| ADediting_254786 | chr11_46916371_- | SINE | Alu | Name=AluJb |
| ADediting_254787 | chr11_46916378_- | SINE | Alu | Name=AluJb |
| ADediting_254788 | chr11_46916380_- | SINE | Alu | Name=AluJb |
| ADediting_254789 | chr11_46916388_- | SINE | Alu | Name=AluJb |
| ADediting_254790 | chr11_46916394_- | SINE | Alu | Name=AluJb |
| ADediting_254791 | chr11_46916406_- | SINE | Alu | Name=AluJb |
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RNA A-to-I editing events in the alternative splicing sites for LRP4 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for LRP4 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |