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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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Gene summary for LRP4 |
 Gene summary |
| Gene information | Gene symbol | LRP4 | Gene ID | 4038 |
| Gene name | LDL receptor related protein 4 | |
| Synonyms | CLSS|CMS17|LRP-4|LRP10|MEGF7|SOST2 | |
| Cytomap | 11p11.2 | |
| Type of gene | protein-coding | |
| Description | low-density lipoprotein receptor-related protein 4multiple epidermal growth factor-like domains 7 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| LRP4 | GO:0001822 | kidney development | 20381006 |
| LRP4 | GO:0060173 | limb development | 20381006 |
| LRP4 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 20093106 |
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RNA A-to-I events for LRP4 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_254716(46884347, -), ADediting_254717(46884359, -), ADediting_254718(46884779, -), ADediting_254719(46884811, -), ADediting_254720(46884827, -), ADediting_254721(46885028, -), ADediting_254722(46885100, -), ADediting_254723(46885124, -), ADediting_254724(46885139, -), ADediting_254725(46885140, -), ADediting_254726(46885219, -), ADediting_254727(46885272, -), ADediting_254728(46885276, -), ADediting_254729(46885529, -), ADediting_254730(46885539, -), ADediting_254731(46901914, -), ADediting_254732(46903321, -), ADediting_254733(46903325, -), ADediting_254734(46904919, -), ADediting_254735(46908007, -), ADediting_254736(46908008, -), ADediting_254737(46908043, -), ADediting_254738(46908056, -), ADediting_254739(46908060, -), ADediting_254740(46908202, -), ADediting_254741(46908203, -), ADediting_254742(46908219, -), ADediting_254743(46909350, -), ADediting_254744(46909362, -), ADediting_254745(46910746, -), ADediting_254746(46910747, -), ADediting_254747(46910756, -), ADediting_254748(46910770, -), ADediting_254749(46911532, -), ADediting_254750(46911537, -), ADediting_254751(46911570, -), ADediting_254752(46911910, -), ADediting_254753(46911915, -), ADediting_254754(46911939, -), ADediting_254755(46911995, -), ADediting_254756(46912018, -), ADediting_254757(46912057, -), ADediting_254758(46912135, -), ADediting_254759(46912149, -), ADediting_254760(46915606, -), ADediting_254761(46915611, -), ADediting_254762(46915612, -), ADediting_254763(46915619, -), ADediting_254764(46915620, -), ADediting_254765(46915626, -), ADediting_254766(46915692, -), ADediting_254767(46915698, -), ADediting_254768(46915704, -), ADediting_254769(46915708, -), ADediting_254770(46915712, -), ADediting_254771(46915713, -), ADediting_254772(46915737, -), ADediting_254773(46915738, -), ADediting_254774(46915739, -), ADediting_254775(46915740, -), ADediting_254776(46915747, -), ADediting_254777(46915757, -), ADediting_254778(46915789, -), ADediting_254779(46916242, -), ADediting_254780(46916259, -), ADediting_254781(46916295, -), ADediting_254782(46916302, -), ADediting_254783(46916308, -), ADediting_254784(46916327, -), ADediting_254785(46916328, -), ADediting_254786(46916371, -), ADediting_254787(46916378, -), ADediting_254788(46916380, -), ADediting_254789(46916388, -), ADediting_254790(46916394, -), ADediting_254791(46916406, -), ADediting_254792(46916877, -), |
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RNA editing positional annotations for LRP4 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_254716 | chr11_46884347_- | intronic |
| ADediting_254717 | chr11_46884359_- | intronic |
| ADediting_254718 | chr11_46884779_- | intronic |
| ADediting_254719 | chr11_46884811_- | intronic |
| ADediting_254720 | chr11_46884827_- | intronic |
| ADediting_254721 | chr11_46885028_- | intronic |
| ADediting_254722 | chr11_46885100_- | intronic |
| ADediting_254723 | chr11_46885124_- | intronic |
| ADediting_254724 | chr11_46885139_- | intronic |
| ADediting_254725 | chr11_46885140_- | intronic |
| ADediting_254726 | chr11_46885219_- | intronic |
| ADediting_254727 | chr11_46885272_- | intronic |
| ADediting_254728 | chr11_46885276_- | intronic |
| ADediting_254729 | chr11_46885529_- | intronic |
| ADediting_254730 | chr11_46885539_- | intronic |
| ADediting_254731 | chr11_46901914_- | intronic |
| ADediting_254732 | chr11_46903321_- | intronic |
| ADediting_254733 | chr11_46903325_- | intronic |
| ADediting_254734 | chr11_46904919_- | intronic |
| ADediting_254735 | chr11_46908007_- | intronic |
| ADediting_254736 | chr11_46908008_- | intronic |
| ADediting_254737 | chr11_46908043_- | intronic |
| ADediting_254738 | chr11_46908056_- | intronic |
| ADediting_254739 | chr11_46908060_- | intronic |
| ADediting_254740 | chr11_46908202_- | intronic |
| ADediting_254741 | chr11_46908203_- | intronic |
| ADediting_254742 | chr11_46908219_- | intronic |
| ADediting_254743 | chr11_46909350_- | intronic |
| ADediting_254744 | chr11_46909362_- | intronic |
| ADediting_254745 | chr11_46910746_- | intronic |
| ADediting_254746 | chr11_46910747_- | intronic |
| ADediting_254747 | chr11_46910756_- | intronic |
| ADediting_254748 | chr11_46910770_- | intronic |
| ADediting_254749 | chr11_46911532_- | intronic |
| ADediting_254750 | chr11_46911537_- | intronic |
| ADediting_254751 | chr11_46911570_- | intronic |
| ADediting_254752 | chr11_46911910_- | intronic |
| ADediting_254753 | chr11_46911915_- | intronic |
| ADediting_254754 | chr11_46911939_- | intronic |
| ADediting_254755 | chr11_46911995_- | intronic |
| ADediting_254756 | chr11_46912018_- | intronic |
| ADediting_254757 | chr11_46912057_- | intronic |
| ADediting_254758 | chr11_46912135_- | intronic |
| ADediting_254759 | chr11_46912149_- | intronic |
| ADediting_254760 | chr11_46915606_- | intronic |
| ADediting_254761 | chr11_46915611_- | intronic |
| ADediting_254762 | chr11_46915612_- | intronic |
| ADediting_254763 | chr11_46915619_- | intronic |
| ADediting_254764 | chr11_46915620_- | intronic |
| ADediting_254765 | chr11_46915626_- | intronic |
| ADediting_254766 | chr11_46915692_- | intronic |
| ADediting_254767 | chr11_46915698_- | intronic |
| ADediting_254768 | chr11_46915704_- | intronic |
| ADediting_254769 | chr11_46915708_- | intronic |
| ADediting_254770 | chr11_46915712_- | intronic |
| ADediting_254771 | chr11_46915713_- | intronic |
| ADediting_254772 | chr11_46915737_- | intronic |
| ADediting_254773 | chr11_46915738_- | intronic |
| ADediting_254774 | chr11_46915739_- | intronic |
| ADediting_254775 | chr11_46915740_- | intronic |
| ADediting_254776 | chr11_46915747_- | intronic |
| ADediting_254777 | chr11_46915757_- | intronic |
| ADediting_254778 | chr11_46915789_- | intronic |
| ADediting_254779 | chr11_46916242_- | intronic |
| ADediting_254780 | chr11_46916259_- | intronic |
| ADediting_254781 | chr11_46916295_- | intronic |
| ADediting_254782 | chr11_46916302_- | intronic |
| ADediting_254783 | chr11_46916308_- | intronic |
| ADediting_254784 | chr11_46916327_- | intronic |
| ADediting_254785 | chr11_46916328_- | intronic |
| ADediting_254786 | chr11_46916371_- | intronic |
| ADediting_254787 | chr11_46916378_- | intronic |
| ADediting_254788 | chr11_46916380_- | intronic |
| ADediting_254789 | chr11_46916388_- | intronic |
| ADediting_254790 | chr11_46916394_- | intronic |
| ADediting_254791 | chr11_46916406_- | intronic |
| ADediting_254792 | chr11_46916877_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_254716 | chr11_46884347_- | SINE | Alu | Name=AluSg |
| ADediting_254717 | chr11_46884359_- | SINE | Alu | Name=AluSg |
| ADediting_254718 | chr11_46884779_- | SINE | Alu | Name=AluSg |
| ADediting_254719 | chr11_46884811_- | SINE | Alu | Name=AluSg |
| ADediting_254720 | chr11_46884827_- | SINE | Alu | Name=AluSg |
| ADediting_254721 | chr11_46885028_- | SINE | Alu | Name=AluJo |
| ADediting_254722 | chr11_46885100_- | SINE | Alu | Name=AluJo |
| ADediting_254723 | chr11_46885124_- | SINE | Alu | Name=AluJo |
| ADediting_254724 | chr11_46885139_- | SINE | Alu | Name=AluJo |
| ADediting_254725 | chr11_46885140_- | SINE | Alu | Name=AluJo |
| ADediting_254726 | chr11_46885219_- | SINE | Alu | Name=AluJo |
| ADediting_254727 | chr11_46885272_- | SINE | Alu | Name=AluJo |
| ADediting_254728 | chr11_46885276_- | SINE | Alu | Name=AluJo |
| ADediting_254729 | chr11_46885529_- | SINE | Alu | Name=AluSc |
| ADediting_254730 | chr11_46885539_- | SINE | Alu | Name=AluSc |
| ADediting_254731 | chr11_46901914_- | SINE | Alu | Name=AluY |
| ADediting_254732 | chr11_46903321_- | SINE | Alu | Name=AluJo |
| ADediting_254733 | chr11_46903325_- | SINE | Alu | Name=AluJo |
| ADediting_254734 | chr11_46904919_- | SINE | Alu | Name=AluJb |
| ADediting_254735 | chr11_46908007_- | SINE | Alu | Name=AluSx1 |
| ADediting_254736 | chr11_46908008_- | SINE | Alu | Name=AluSx1 |
| ADediting_254737 | chr11_46908043_- | SINE | Alu | Name=AluSx1 |
| ADediting_254738 | chr11_46908056_- | SINE | Alu | Name=AluSx1 |
| ADediting_254739 | chr11_46908060_- | SINE | Alu | Name=AluSx1 |
| ADediting_254740 | chr11_46908202_- | SINE | Alu | Name=AluSx1 |
| ADediting_254741 | chr11_46908203_- | SINE | Alu | Name=AluSx1 |
| ADediting_254742 | chr11_46908219_- | SINE | Alu | Name=AluSx1 |
| ADediting_254743 | chr11_46909350_- | SINE | Alu | Name=AluYb8 |
| ADediting_254744 | chr11_46909362_- | SINE | Alu | Name=AluYb8 |
| ADediting_254745 | chr11_46910746_- | SINE | Alu | Name=AluSz |
| ADediting_254746 | chr11_46910747_- | SINE | Alu | Name=AluSz |
| ADediting_254747 | chr11_46910756_- | SINE | Alu | Name=AluSz |
| ADediting_254748 | chr11_46910770_- | SINE | Alu | Name=AluSz |
| ADediting_254749 | chr11_46911532_- | SINE | Alu | Name=AluJo |
| ADediting_254750 | chr11_46911537_- | SINE | Alu | Name=AluJo |
| ADediting_254751 | chr11_46911570_- | SINE | Alu | Name=AluJo |
| ADediting_254752 | chr11_46911910_- | SINE | Alu | Name=AluSz |
| ADediting_254753 | chr11_46911915_- | SINE | Alu | Name=AluSz |
| ADediting_254754 | chr11_46911939_- | SINE | Alu | Name=AluSz |
| ADediting_254755 | chr11_46911995_- | SINE | Alu | Name=AluSz |
| ADediting_254756 | chr11_46912018_- | SINE | Alu | Name=AluSz |
| ADediting_254757 | chr11_46912057_- | SINE | Alu | Name=AluSz |
| ADediting_254758 | chr11_46912135_- | SINE | Alu | Name=AluSz |
| ADediting_254759 | chr11_46912149_- | SINE | Alu | Name=AluSz |
| ADediting_254760 | chr11_46915606_- | SINE | Alu | Name=AluSz6 |
| ADediting_254761 | chr11_46915611_- | SINE | Alu | Name=AluSz6 |
| ADediting_254762 | chr11_46915612_- | SINE | Alu | Name=AluSz6 |
| ADediting_254763 | chr11_46915619_- | SINE | Alu | Name=AluSz6 |
| ADediting_254764 | chr11_46915620_- | SINE | Alu | Name=AluSz6 |
| ADediting_254765 | chr11_46915626_- | SINE | Alu | Name=AluSz6 |
| ADediting_254766 | chr11_46915692_- | SINE | Alu | Name=AluSz6 |
| ADediting_254767 | chr11_46915698_- | SINE | Alu | Name=AluSz6 |
| ADediting_254768 | chr11_46915704_- | SINE | Alu | Name=AluSz6 |
| ADediting_254769 | chr11_46915708_- | SINE | Alu | Name=AluSz6 |
| ADediting_254770 | chr11_46915712_- | SINE | Alu | Name=AluSz6 |
| ADediting_254771 | chr11_46915713_- | SINE | Alu | Name=AluSz6 |
| ADediting_254772 | chr11_46915737_- | SINE | Alu | Name=AluSz6 |
| ADediting_254773 | chr11_46915738_- | SINE | Alu | Name=AluSz6 |
| ADediting_254774 | chr11_46915739_- | SINE | Alu | Name=AluSz6 |
| ADediting_254775 | chr11_46915740_- | SINE | Alu | Name=AluSz6 |
| ADediting_254776 | chr11_46915747_- | SINE | Alu | Name=AluSz6 |
| ADediting_254777 | chr11_46915757_- | SINE | Alu | Name=AluSz6 |
| ADediting_254778 | chr11_46915789_- | SINE | Alu | Name=AluSz6 |
| ADediting_254779 | chr11_46916242_- | SINE | Alu | Name=AluJb |
| ADediting_254780 | chr11_46916259_- | SINE | Alu | Name=AluJb |
| ADediting_254781 | chr11_46916295_- | SINE | Alu | Name=AluJb |
| ADediting_254782 | chr11_46916302_- | SINE | Alu | Name=AluJb |
| ADediting_254783 | chr11_46916308_- | SINE | Alu | Name=AluJb |
| ADediting_254784 | chr11_46916327_- | SINE | Alu | Name=AluJb |
| ADediting_254785 | chr11_46916328_- | SINE | Alu | Name=AluJb |
| ADediting_254786 | chr11_46916371_- | SINE | Alu | Name=AluJb |
| ADediting_254787 | chr11_46916378_- | SINE | Alu | Name=AluJb |
| ADediting_254788 | chr11_46916380_- | SINE | Alu | Name=AluJb |
| ADediting_254789 | chr11_46916388_- | SINE | Alu | Name=AluJb |
| ADediting_254790 | chr11_46916394_- | SINE | Alu | Name=AluJb |
| ADediting_254791 | chr11_46916406_- | SINE | Alu | Name=AluJb |
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RNA A-to-I editing events in the alternative splicing sites for LRP4 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for LRP4 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for LRP4 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for LRP4 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000134569.10 | ENST00000378623.6 | LRP4-201 | hsa-miR-589-3p | chr11 | 46856824 | 46856830 | 7mer-m8 | 46856823 | 46856846 | 158 | -18.66 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000134569.10 | ENST00000378623.6 | LRP4-201 | hsa-miR-641 | chr11 | 46858041 | 46858047 | 7mer-m8 | 46858040 | 46858065 | 159 | -18.25 |
| ADediting_496066 | chr15_66496985_- | ENSG00000134569.10 | ENST00000378623.6 | LRP4-201 | hsa-miR-4512 | chr11 | 46858900 | 46858906 | 7mer-m8 | 46858899 | 46858921 | 150 | -24.92 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000134569.10 | ENST00000378623.6 | LRP4-201 | hsa-miR-5688 | chr11 | 46857642 | 46857648 | 7mer-m8 | 46857641 | 46857659 | 151 | -10.49 |
| ADediting_496066 | chr15_66496985_- | ENSG00000134569.10 | ENST00000378623.6 | LRP4-201 | hsa-miR-4512 | chr11 | 46857276 | 46857282 | 7mer-m8 | 46857275 | 46857293 | 147 | -17.52 |
| ADediting_496066 | chr15_66496985_- | ENSG00000134569.10 | ENST00000378623.6 | LRP4-201 | hsa-miR-4512 | chr11 | 46857501 | 46857507 | 7mer-m8 | 46857500 | 46857522 | 154 | -20.24 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for LRP4 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for LRP4 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| TCX | ADediting_254717 | chr11_46884359_- | 0.0874134352776603 | 0.140038752843587 | 0.749399286987592 | -0.0262969517614759 | 9.60467469417106e-05 | 0.3130404803497 |
| DLPFC | ADediting_254720 | chr11_46884827_- | 0.230329993680594 | 0.0683239216314771 | 0.591442644313583 | -0.0306016422595859 | 5.01467760407786e-10 | 0.343762243914484 |
| TCX | ADediting_254720 | chr11_46884827_- | 0.62080449999038 | 0.0407167992253833 | 0.0208543417298846 | -0.188542545335537 | 2.75403661286405e-06 | 0.372080007812354 |
| FP | ADediting_254720 | chr11_46884827_- | 0.193991693181826 | 0.0978092286995123 | 0.465051729079372 | -0.0551039233072999 | 1.1864344929591e-08 | 0.411199106915551 |
| DLPFC | ADediting_254722 | chr11_46885100_- | 0.176201164216935 | 0.0770163559255202 | 0.870886121977566 | -0.00926849985801387 | 1.27074055586439e-09 | 0.336088746592328 |
| CER | ADediting_254722 | chr11_46885100_- | 0.0305240668777058 | 0.176712221603726 | 0.0036266423415479 | 0.23612075523461 | 7.90930088145067e-06 | 0.355750260060698 |
| TCX | ADediting_254722 | chr11_46885100_- | 0.958932326178288 | 0.00423987180203135 | 0.00547924489240868 | -0.225729116926614 | 2.65549449574658e-05 | 0.335817199307865 |
| FP | ADediting_254722 | chr11_46885100_- | 0.481564811347171 | -0.0530879445565557 | 0.210479414346202 | -0.0943150802084605 | 6.38711883372191e-06 | 0.331021142240749 |
| DLPFC | ADediting_254723 | chr11_46885124_- | 0.0242410382498426 | 0.127968475115062 | 0.507339866640086 | 0.0377942676931473 | 3.21147340480395e-10 | 0.347367123988805 |
| DLPFC | ADediting_254724 | chr11_46885139_- | 0.266852356314751 | 0.0632554621403851 | 0.525934778832372 | -0.0361557720147515 | 7.17920164927201e-08 | 0.300073047433729 |
| TCX | ADediting_254724 | chr11_46885139_- | 0.989370283768644 | 0.00109697585426484 | 0.0455525624170482 | -0.163527081497566 | 6.79686163681548e-05 | 0.31934753581669 |
| DLPFC | ADediting_254725 | chr11_46885140_- | 0.100457332209853 | 0.0934689593099986 | 0.714761771515886 | -0.0208391424920002 | 4.50494804394996e-13 | 0.395854951585193 |
| TCX | ADediting_254725 | chr11_46885140_- | 0.719544981717811 | 0.0295585593454083 | 0.113876739579461 | -0.129627704087936 | 1.18695145680181e-05 | 0.34921935860178 |
| TCX | ADediting_254727 | chr11_46885272_- | 0.915162030534867 | 0.00877132908599442 | 0.0291532388630544 | -0.178174046784506 | 9.5871909110591e-05 | 0.313074084405249 |
| DLPFC | ADediting_254785 | chr11_46916328_- | 0.91309870837876 | 0.00622329622841795 | 0.252030553323819 | -0.0652503693064879 | 1.05211259356034e-09 | 0.337663940921817 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 0.000669619026919082 | 0.192177403839841 | 0.090217628990659 | 0.0963921909940518 | 1.23134080139799e-10 | 0.354969832586888 |
| AC | 4.14211112703969e-24 | 0.582483943503133 | 1.04154635427355e-12 | 0.430621129175573 | 9.77157013113402e-38 | 0.697331904577738 |
| PCC | 0.0584496610001903 | 0.137175244763159 | 0.239305910127532 | 0.0855501046206316 | 8.40752782282487e-12 | 0.468293784120252 |
| CER | 0.000109302208256772 | 0.310645780411301 | 3.06579215347935e-05 | 0.333359656031652 | 1.70657510424421e-25 | 0.722497380829817 |
| TCX | 0.239500721938923 | 0.0966226409721755 | 0.0147153839999289 | -0.198839172535648 | 4.70846351038876e-12 | 0.526117260489372 |
| FP | 0.0296207408660741 | 0.163088398321282 | 0.982202569887621 | 0.00168388916906367 | 5.1257063712108e-24 | 0.664250959719198 |
| IFG | 0.0618202114799181 | 0.378850930499704 | 0.0423323084071364 | 0.409028479525847 | 0.000106521163834751 | 0.697479156947226 |
| PG | 5.23380654524241e-13 | 0.497215983149412 | 0.000177641982744089 | 0.271527675476315 | 3.02070725180612e-07 | 0.364996166253435 |
| STG | 0.241753417000288 | 0.129123864822141 | 0.512047991215195 | -0.0725299814816365 | 1.81479546385024e-12 | 0.675478140635266 |
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Relation with AD stages for LRP4 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| TCX | ADediting_254720 | chr11_46884827_- | 0.00173020817671805 | 0.300792046578992 |
| TCX | ADediting_254723 | chr11_46885124_- | 0.000220783397918118 | 0.351441073679912 |
| TCX | ADediting_254724 | chr11_46885139_- | 0.000332941905450702 | 0.342003022480017 |
| TCX | ADediting_254725 | chr11_46885140_- | 0.000213857311439658 | 0.352161162016743 |
| TCX | ADediting_254727 | chr11_46885272_- | 0.000640237734099054 | 0.326336723170129 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 4.02361042396577e-07 | 0.464815473166854 |
| TCX | 4.57449525043101e-10 | 0.559395717747818 |
| PG | 4.98158521394289e-08 | 0.386702766145424 |
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RelatedDrugs for LRP4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LRP4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| LRP4 | C0751882 | Myasthenic Syndromes, Congenital | 2 | CTD_human;GENOMICS_ENGLAND |
| LRP4 | C3280402 | SCLEROSTEOSIS 2 | 2 | UNIPROT |
| LRP4 | C0039075 | Syndactyly | 1 | CTD_human |
| LRP4 | C0040427 | Tooth Abnormalities | 1 | CTD_human |
| LRP4 | C0265553 | Polysyndactyly | 1 | CTD_human |
| LRP4 | C0524730 | Odontome | 1 | CTD_human |
| LRP4 | C1859309 | Syndactyly Cenani Lenz type | 1 | CTD_human;ORPHANET;UNIPROT |
| LRP4 | C4225377 | MYASTHENIC SYNDROME, CONGENITAL, 17 | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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