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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for GPR153 |
 Gene summary |
| Gene information | Gene symbol | GPR153 | Gene ID | 387509 |
| Gene name | G protein-coupled receptor 153 | |
| Synonyms | PGR1 | |
| Cytomap | 1p36.31 | |
| Type of gene | protein-coding | |
| Description | probable G-protein coupled receptor 153G-protein coupled receptor PGR1 | |
| Modification date | 20200313 | |
| UniProtAcc | Q6NV75, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for GPR153 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_132460(6251857, -), ADediting_132461(6251893, -), ADediting_132462(6251894, -), ADediting_132463(6251933, -), ADediting_132464(6251934, -), ADediting_132466(6253133, -), ADediting_132467(6253135, -), ADediting_132468(6253141, -), ADediting_132469(6253157, -), ADediting_132470(6253162, -), ADediting_132471(6253175, -), ADediting_132472(6253296, -), ADediting_132473(6253313, -), ADediting_132474(6253314, -), ADediting_132475(6253333, -), ADediting_132476(6253344, -), ADediting_132477(6253349, -), ADediting_132478(6253352, -), ADediting_132479(6253357, -), ADediting_132484(6255363, -), ADediting_132486(6255596, -), ADediting_132487(6255621, -), ADediting_132488(6255715, -), ADediting_132489(6255720, -), ADediting_132490(6255781, -), ADediting_132491(6255790, -), ADediting_132492(6255817, -), ADediting_132493(6255924, -), ADediting_132494(6256022, -), ADediting_132495(6256597, -), ADediting_132496(6256789, -), ADediting_132500(6258171, -), ADediting_132501(6258220, -), ADediting_132502(6258265, -), ADediting_132503(6258330, -), ADediting_132504(6258356, -), ADediting_132505(6258401, -), ADediting_132506(6259010, -), ADediting_132507(6259039, -), ADediting_132508(6259043, -), ADediting_132509(6259139, -), ADediting_132510(6259149, -), ADediting_132511(6259153, -), ADediting_132512(6259161, -), ADediting_132513(6259205, -), ADediting_132514(6259216, -), ADediting_132515(6259231, -), ADediting_132516(6259248, -), ADediting_132517(6259256, -), ADediting_132518(6259261, -), ADediting_1521213(6251928, -), |
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RNA editing positional annotations for GPR153 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_132460 | chr1_6251857_- | intronic |
| ADediting_132461 | chr1_6251893_- | intronic |
| ADediting_132462 | chr1_6251894_- | intronic |
| ADediting_132463 | chr1_6251933_- | intronic |
| ADediting_132464 | chr1_6251934_- | intronic |
| ADediting_132466 | chr1_6253133_- | intronic |
| ADediting_132467 | chr1_6253135_- | intronic |
| ADediting_132468 | chr1_6253141_- | intronic |
| ADediting_132469 | chr1_6253157_- | intronic |
| ADediting_132470 | chr1_6253162_- | intronic |
| ADediting_132471 | chr1_6253175_- | intronic |
| ADediting_132472 | chr1_6253296_- | intronic |
| ADediting_132473 | chr1_6253313_- | intronic |
| ADediting_132474 | chr1_6253314_- | intronic |
| ADediting_132475 | chr1_6253333_- | intronic |
| ADediting_132476 | chr1_6253344_- | intronic |
| ADediting_132477 | chr1_6253349_- | intronic |
| ADediting_132478 | chr1_6253352_- | intronic |
| ADediting_132479 | chr1_6253357_- | intronic |
| ADediting_132484 | chr1_6255363_- | intronic |
| ADediting_132486 | chr1_6255596_- | intronic |
| ADediting_132487 | chr1_6255621_- | intronic |
| ADediting_132488 | chr1_6255715_- | intronic |
| ADediting_132489 | chr1_6255720_- | intronic |
| ADediting_132490 | chr1_6255781_- | intronic |
| ADediting_132491 | chr1_6255790_- | intronic |
| ADediting_132492 | chr1_6255817_- | intronic |
| ADediting_132493 | chr1_6255924_- | intronic |
| ADediting_132494 | chr1_6256022_- | intronic |
| ADediting_132495 | chr1_6256597_- | intronic |
| ADediting_132496 | chr1_6256789_- | intronic |
| ADediting_132500 | chr1_6258171_- | intronic |
| ADediting_132501 | chr1_6258220_- | intronic |
| ADediting_132502 | chr1_6258265_- | intronic |
| ADediting_132503 | chr1_6258330_- | intronic |
| ADediting_132504 | chr1_6258356_- | intronic |
| ADediting_132505 | chr1_6258401_- | intronic |
| ADediting_132506 | chr1_6259010_- | intronic |
| ADediting_132507 | chr1_6259039_- | intronic |
| ADediting_132508 | chr1_6259043_- | intronic |
| ADediting_132509 | chr1_6259139_- | intronic |
| ADediting_132510 | chr1_6259149_- | intronic |
| ADediting_132511 | chr1_6259153_- | intronic |
| ADediting_132512 | chr1_6259161_- | intronic |
| ADediting_132513 | chr1_6259205_- | intronic |
| ADediting_132514 | chr1_6259216_- | intronic |
| ADediting_132515 | chr1_6259231_- | intronic |
| ADediting_132516 | chr1_6259248_- | intronic |
| ADediting_132517 | chr1_6259256_- | intronic |
| ADediting_132518 | chr1_6259261_- | intronic |
| ADediting_1521213 | chr1_6251928_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_132460 | chr1_6251857_- | SINE | Alu | Name=AluJb |
| ADediting_132461 | chr1_6251893_- | SINE | Alu | Name=AluJb |
| ADediting_132462 | chr1_6251894_- | SINE | Alu | Name=AluJb |
| ADediting_132463 | chr1_6251933_- | SINE | Alu | Name=AluJb |
| ADediting_132464 | chr1_6251934_- | SINE | Alu | Name=AluJb |
| ADediting_132466 | chr1_6253133_- | SINE | Alu | Name=AluSq2 |
| ADediting_132467 | chr1_6253135_- | SINE | Alu | Name=AluSq2 |
| ADediting_132468 | chr1_6253141_- | SINE | Alu | Name=AluSq2 |
| ADediting_132469 | chr1_6253157_- | SINE | Alu | Name=AluSq2 |
| ADediting_132470 | chr1_6253162_- | SINE | Alu | Name=AluSq2 |
| ADediting_132471 | chr1_6253175_- | SINE | Alu | Name=AluSq2 |
| ADediting_132472 | chr1_6253296_- | SINE | Alu | Name=AluSq2 |
| ADediting_132473 | chr1_6253313_- | SINE | Alu | Name=AluSq2 |
| ADediting_132474 | chr1_6253314_- | SINE | Alu | Name=AluSq2 |
| ADediting_132475 | chr1_6253333_- | SINE | Alu | Name=AluSq2 |
| ADediting_132476 | chr1_6253344_- | SINE | Alu | Name=AluSq2 |
| ADediting_132477 | chr1_6253349_- | SINE | Alu | Name=AluSq2 |
| ADediting_132478 | chr1_6253352_- | SINE | Alu | Name=AluSq2 |
| ADediting_132479 | chr1_6253357_- | SINE | Alu | Name=AluSq2 |
| ADediting_132484 | chr1_6255363_- | SINE | Alu | Name=AluY |
| ADediting_132486 | chr1_6255596_- | SINE | Alu | Name=AluJr |
| ADediting_132487 | chr1_6255621_- | SINE | Alu | Name=AluJr |
| ADediting_132488 | chr1_6255715_- | SINE | Alu | Name=AluSx3 |
| ADediting_132489 | chr1_6255720_- | SINE | Alu | Name=AluSx3 |
| ADediting_132490 | chr1_6255781_- | SINE | Alu | Name=AluSx3 |
| ADediting_132491 | chr1_6255790_- | SINE | Alu | Name=AluSx3 |
| ADediting_132492 | chr1_6255817_- | SINE | Alu | Name=AluSx3 |
| ADediting_132493 | chr1_6255924_- | SINE | Alu | Name=AluSx3 |
| ADediting_132494 | chr1_6256022_- | SINE | Alu | Name=AluJr |
| ADediting_132495 | chr1_6256597_- | SINE | Alu | Name=AluSz6 |
| ADediting_132496 | chr1_6256789_- | SINE | Alu | Name=FLAM_A |
| ADediting_132500 | chr1_6258171_- | SINE | Alu | Name=AluSq |
| ADediting_132501 | chr1_6258220_- | SINE | Alu | Name=AluSq |
| ADediting_132502 | chr1_6258265_- | SINE | Alu | Name=AluSq |
| ADediting_132503 | chr1_6258330_- | SINE | Alu | Name=AluSq |
| ADediting_132504 | chr1_6258356_- | SINE | Alu | Name=AluSq |
| ADediting_132505 | chr1_6258401_- | SINE | Alu | Name=AluSq |
| ADediting_132506 | chr1_6259010_- | SINE | Alu | Name=AluJb |
| ADediting_132507 | chr1_6259039_- | SINE | Alu | Name=AluJb |
| ADediting_132508 | chr1_6259043_- | SINE | Alu | Name=AluJb |
| ADediting_132509 | chr1_6259139_- | SINE | Alu | Name=AluJb |
| ADediting_132510 | chr1_6259149_- | SINE | Alu | Name=AluJb |
| ADediting_132511 | chr1_6259153_- | SINE | Alu | Name=AluJb |
| ADediting_132512 | chr1_6259161_- | SINE | Alu | Name=AluJb |
| ADediting_132513 | chr1_6259205_- | SINE | Alu | Name=AluJb |
| ADediting_132514 | chr1_6259216_- | SINE | Alu | Name=AluJb |
| ADediting_132515 | chr1_6259231_- | SINE | Alu | Name=AluJb |
| ADediting_132516 | chr1_6259248_- | SINE | Alu | Name=AluJb |
| ADediting_132517 | chr1_6259256_- | SINE | Alu | Name=AluJb |
| ADediting_132518 | chr1_6259261_- | SINE | Alu | Name=AluJb |
| ADediting_1521213 | chr1_6251928_- | SINE | Alu | Name=AluJb |
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RNA A-to-I editing events in the alternative splicing sites for GPR153 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GPR153 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for GPR153 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for GPR153 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000158292.7 | ENST00000377893.3 | GPR153-201 | hsa-miR-5688 | chr1 | 6249196 | 6249202 | 7mer-m8 | 6249195 | 6249215 | 143 | -15.02 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000158292.7 | ENST00000377893.3 | GPR153-201 | hsa-miR-589-3p | chr1 | 6247634 | 6247640 | 7mer-m8 | 6247633 | 6247656 | 154 | -21.05 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000158292.7 | ENST00000377893.3 | GPR153-201 | hsa-miR-337-3p | chr1 | 6247381 | 6247387 | 7mer-m8 | 6247380 | 6247402 | 144 | -12.4 |
| ADediting_1596844 | chr1_162342605_+ | ENSG00000158292.7 | ENST00000377893.3 | GPR153-201 | hsa-miR-556-3p | chr1 | 6247610 | 6247616 | 7mer-m8 | 6247609 | 6247629 | 152 | -7.42 |
| ADediting_496066 | chr15_66496985_- | ENSG00000158292.7 | ENST00000377893.3 | GPR153-201 | hsa-miR-4512 | chr1 | 6247881 | 6247887 | 7mer-m8 | 6247880 | 6247899 | 152 | -19.55 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337758 | chr7_5495892_- | ENSG00000158292.7 | ENST00000377893.3 | GPR153-201 | hsa-miR-589-5p | chr1 | 6248278 | 6248285 | 8mer-1a | 6248278 | 6248299 | 148 | -22.3 |
| ADediting_496066 | chr15_66496985_- | ENSG00000158292.7 | ENST00000377893.3 | GPR153-201 | hsa-miR-4512 | chr1 | 6248702 | 6248708 | 7mer-m8 | 6248701 | 6248723 | 141 | -16.59 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for GPR153 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for GPR153 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_132472 | chr1_6253296_- | 0.00334043542515986 | 0.166181521971093 | 0.375666221019449 | 0.0504881492427816 | 4.61772524342819e-11 | 0.362544460405865 |
| DLPFC | ADediting_132473 | chr1_6253313_- | 0.00541056973208202 | 0.157627477533416 | 0.108866414002729 | 0.0912403991205041 | 2.45416509153847e-08 | 0.310133020685859 |
| DLPFC | ADediting_132474 | chr1_6253314_- | 0.0300292426616436 | 0.123258596907457 | 0.43273692218983 | 0.0447159098960232 | 2.20753177123533e-08 | 0.311105418241652 |
| DLPFC | ADediting_132475 | chr1_6253333_- | 0.00141898363765036 | 0.180461979727597 | 0.0550940256467564 | 0.109058106718651 | 2.73283276996268e-13 | 0.399235685257201 |
| DLPFC | ADediting_132479 | chr1_6253357_- | 0.00116433547597298 | 0.183615385326097 | 0.0534231978736686 | 0.109812573126349 | 4.01450746752654e-10 | 0.345567477234709 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 4.7617396141772e-24 | 0.531978674155975 | 6.83283730263901e-28 | 0.568117404383038 | 0.0001191821835179 | 0.216811278172767 |
| AC | 7.93106795002424e-48 | 0.75747686642011 | 1.17695683684368e-52 | 0.781171776513016 | 7.82992807841195e-07 | 0.306394661161458 |
| PCC | 2.22921259576188e-21 | 0.616471429075675 | 5.59983398129617e-25 | 0.657059880275709 | 0.0443792504824816 | 0.145653408896468 |
| CER | 0.000111064990046368 | 0.310348007461487 | 6.56500822926805e-07 | 0.392940609429518 | 3.97783393429578e-08 | 0.430017706626625 |
| TCX | 5.11897029494604e-05 | 0.324416135611972 | 6.75979845804038e-09 | 0.451348866157006 | 0.0441737040027595 | -0.164569552886191 |
| FP | 1.8191969055568e-05 | 0.315240608918403 | 0.211897227834361 | 0.0940239446888512 | 0.000379564148052108 | 0.263508910854337 |
| IFG | 6.81780509978208e-05 | 0.710856316066137 | 1.90917406177091e-07 | 0.836401467538307 | 0.336473475230244 | 0.20053565689024 |
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Relation with AD stages for GPR153 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 6.73511717907484e-06 | 0.418049796195325 |
| TCX | 0.00111741274384475 | 0.312303954410676 |
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RelatedDrugs for GPR153 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GPR153 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| GPR153 | C0036341 | Schizophrenia | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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