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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for IRAK1 |
 Gene summary |
| Gene information | Gene symbol | IRAK1 | Gene ID | 3654 |
| Gene name | interleukin 1 receptor associated kinase 1 | |
| Synonyms | IRAK|pelle | |
| Cytomap | Xq28 | |
| Type of gene | protein-coding | |
| Description | interleukin-1 receptor-associated kinase 1IRAK-1Pelle homolog | |
| Modification date | 20200315 | |
| UniProtAcc | P51617, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| IRAK1 | GO:0007250 | activation of NF-kappaB-inducing kinase activity | 11397809 |
| IRAK1 | GO:0046777 | protein autophosphorylation | 10383454|12054681 |
| IRAK1 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 10383454 |
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RNA A-to-I events for IRAK1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1493984(154011115, -), ADediting_1493985(154011199, -), ADediting_1493986(154011217, -), ADediting_1493987(154011236, -), ADediting_1493988(154011293, -), ADediting_1493989(154011299, -), ADediting_1493990(154011309, -), ADediting_1493991(154011336, -), ADediting_1493992(154011341, -), ADediting_1493993(154011362, -), ADediting_1493994(154012138, -), ADediting_1493995(154014151, -), ADediting_1594969(154011137, -), ADediting_1594970(154011308, -), ADediting_1594971(154011340, -), |
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RNA editing positional annotations for IRAK1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_1493984 | chrX_154011115_- | nonsynonymous SNV | ENST00000444230.5 | c.A530G | p.Q177R | 0.104 | . | -0.66 |
| ADediting_1493995 | chrX_154014151_- | nonsynonymous SNV | ENST00000369980.8 | c.A1430G | p.H477R | 0.011 | 0.959 | -5.52 |
| ADediting_1493995 | chrX_154014151_- | nonsynonymous SNV | ENST00000393687.6 | c.A1430G | p.H477R | 0.011 | 0.959 | -5.52 |
| ADediting_1493995 | chrX_154014151_- | nonsynonymous SNV | ENST00000429936.6 | c.A1508G | p.H503R | 0.011 | 0.959 | -5.52 |
| ADediting_1493995 | chrX_154014151_- | nonsynonymous SNV | ENST00000455690.5 | c.A170G | p.H57R | 0.011 | 0.959 | -5.52 |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1493984 | chrX_154011115_- | exonic |
| ADediting_1493985 | chrX_154011199_- | UTR3 |
| ADediting_1493986 | chrX_154011217_- | UTR3 |
| ADediting_1493987 | chrX_154011236_- | UTR3 |
| ADediting_1493988 | chrX_154011293_- | UTR3 |
| ADediting_1493989 | chrX_154011299_- | UTR3 |
| ADediting_1493990 | chrX_154011309_- | UTR3 |
| ADediting_1493991 | chrX_154011336_- | UTR3 |
| ADediting_1493992 | chrX_154011341_- | UTR3 |
| ADediting_1493993 | chrX_154011362_- | UTR3 |
| ADediting_1493994 | chrX_154012138_- | intronic |
| ADediting_1493995 | chrX_154014151_- | exonic |
| ADediting_1594969 | chrX_154011137_- | UTR3 |
| ADediting_1594970 | chrX_154011308_- | UTR3 |
| ADediting_1594971 | chrX_154011340_- | UTR3 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1493984 | chrX_154011115_- | SINE | Alu | Name=AluJb |
| ADediting_1493985 | chrX_154011199_- | SINE | Alu | Name=AluJb |
| ADediting_1493986 | chrX_154011217_- | SINE | Alu | Name=AluJb |
| ADediting_1493987 | chrX_154011236_- | SINE | Alu | Name=AluJb |
| ADediting_1493988 | chrX_154011293_- | SINE | Alu | Name=AluJb |
| ADediting_1493989 | chrX_154011299_- | SINE | Alu | Name=AluJb |
| ADediting_1493990 | chrX_154011309_- | SINE | Alu | Name=AluJb |
| ADediting_1493991 | chrX_154011336_- | SINE | Alu | Name=AluJb |
| ADediting_1493992 | chrX_154011341_- | SINE | Alu | Name=AluJb |
| ADediting_1493993 | chrX_154011362_- | SINE | Alu | Name=AluJb |
| ADediting_1493994 | chrX_154012138_- | SINE | Alu | Name=AluJb |
| ADediting_1594969 | chrX_154011137_- | SINE | Alu | Name=AluJb |
| ADediting_1594970 | chrX_154011308_- | SINE | Alu | Name=AluJb |
| ADediting_1594971 | chrX_154011340_- | SINE | Alu | Name=AluJb |
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RNA A-to-I editing events in the alternative splicing sites for IRAK1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for IRAK1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for IRAK1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for IRAK1 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1493985 | chrX_154011199_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-4777-3p | chrX | 154011196 | 154011202 | 7mer-m8 | 154011195 | 154011220 | 145 | -20.49 |
| ADediting_1493985 | chrX_154011199_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-4777-3p | chrX | 154011196 | 154011202 | 7mer-m8 | 154011195 | 154011220 | 145 | -20.49 |
| ADediting_1493988 | chrX_154011293_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-18a-3p | chrX | 154011293 | 154011299 | 7mer-m8 | 154011292 | 154011314 | 150 | -18.68 |
| ADediting_1493988 | chrX_154011293_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-6882-3p | chrX | 154011291 | 154011297 | 7mer-1a | 154011291 | 154011318 | 148 | -27.77 |
| ADediting_1493988 | chrX_154011293_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-18a-3p | chrX | 154011293 | 154011299 | 7mer-m8 | 154011292 | 154011314 | 150 | -18.68 |
| ADediting_1493988 | chrX_154011293_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-6882-3p | chrX | 154011291 | 154011297 | 7mer-1a | 154011291 | 154011318 | 148 | -27.77 |
| ADediting_1493989 | chrX_154011299_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-10396a-3p | chrX | 154011294 | 154011301 | 8mer-1a | 154011294 | 154011316 | 153 | -26.03 |
| ADediting_1493989 | chrX_154011299_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-10396b-3p | chrX | 154011294 | 154011301 | 8mer-1a | 154011294 | 154011317 | 153 | -25.86 |
| ADediting_1493989 | chrX_154011299_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-4707-5p | chrX | 154011296 | 154011302 | 7mer-m8 | 154011295 | 154011316 | 147 | -29.11 |
| ADediting_1493989 | chrX_154011299_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-10396a-3p | chrX | 154011294 | 154011301 | 8mer-1a | 154011294 | 154011316 | 153 | -26.03 |
| ADediting_1493989 | chrX_154011299_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-10396b-3p | chrX | 154011294 | 154011301 | 8mer-1a | 154011294 | 154011317 | 153 | -25.86 |
| ADediting_1493989 | chrX_154011299_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-4707-5p | chrX | 154011296 | 154011302 | 7mer-m8 | 154011295 | 154011316 | 147 | -29.11 |
| ADediting_1493993 | chrX_154011362_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-8052 | chrX | 154011357 | 154011363 | 7mer-1a | 154011357 | 154011375 | 140 | -24.15 |
| ADediting_1493993 | chrX_154011362_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-8052 | chrX | 154011357 | 154011363 | 7mer-1a | 154011357 | 154011375 | 140 | -24.15 |
| ADediting_1594970 | chrX_154011308_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-378a-5p | chrX | 154011306 | 154011312 | 7mer-m8 | 154011305 | 154011329 | 150 | -21.56 |
| ADediting_1594970 | chrX_154011308_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-378a-5p | chrX | 154011306 | 154011312 | 7mer-m8 | 154011305 | 154011329 | 150 | -21.56 |
| ADediting_1594971 | chrX_154011340_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-18a-3p | chrX | 154011335 | 154011341 | 7mer-m8 | 154011334 | 154011354 | 147 | -21.43 |
| ADediting_1594971 | chrX_154011340_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-3176 | chrX | 154011340 | 154011346 | 7mer-m8 | 154011339 | 154011357 | 140 | -15.24 |
| ADediting_1594971 | chrX_154011340_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-3922-3p | chrX | 154011340 | 154011346 | 7mer-m8 | 154011339 | 154011360 | 141 | -19.73 |
| ADediting_1594971 | chrX_154011340_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-874-3p | chrX | 154011336 | 154011342 | 7mer-m8 | 154011335 | 154011358 | 156 | -31.64 |
| ADediting_1594971 | chrX_154011340_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-18a-3p | chrX | 154011335 | 154011341 | 7mer-m8 | 154011334 | 154011354 | 147 | -21.43 |
| ADediting_1594971 | chrX_154011340_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-3176 | chrX | 154011340 | 154011346 | 7mer-m8 | 154011339 | 154011357 | 140 | -15.24 |
| ADediting_1594971 | chrX_154011340_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-3922-3p | chrX | 154011340 | 154011346 | 7mer-m8 | 154011339 | 154011360 | 141 | -19.73 |
| ADediting_1594971 | chrX_154011340_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-874-3p | chrX | 154011336 | 154011342 | 7mer-m8 | 154011335 | 154011358 | 156 | -31.64 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1493984 | chrX_154011115_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-431-5p | chrX | 154011111 | 154011117 | 7mer-m8 | 154011110 | 154011128 | 147 | -17.37 |
| ADediting_1493984 | chrX_154011115_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-5691 | chrX | 154011114 | 154011121 | 8mer-1a | 154011114 | 154011134 | 147 | -19.02 |
| ADediting_1493984 | chrX_154011115_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-6805-3p | chrX | 154011114 | 154011121 | 8mer-1a | 154011114 | 154011136 | 154 | -21.46 |
| ADediting_1493984 | chrX_154011115_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-431-5p | chrX | 154011111 | 154011117 | 7mer-m8 | 154011110 | 154011128 | 147 | -17.37 |
| ADediting_1493984 | chrX_154011115_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-5691 | chrX | 154011114 | 154011121 | 8mer-1a | 154011114 | 154011134 | 147 | -19.02 |
| ADediting_1493984 | chrX_154011115_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-6805-3p | chrX | 154011114 | 154011121 | 8mer-1a | 154011114 | 154011136 | 154 | -21.46 |
| ADediting_1493986 | chrX_154011217_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-1207-3p | chrX | 154011213 | 154011219 | 7mer-m8 | 154011212 | 154011230 | 145 | -15.47 |
| ADediting_1493986 | chrX_154011217_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-1207-3p | chrX | 154011213 | 154011219 | 7mer-m8 | 154011212 | 154011230 | 145 | -15.47 |
| ADediting_1493988 | chrX_154011293_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-6501-5p | chrX | 154011291 | 154011297 | 7mer-1a | 154011291 | 154011312 | 140 | -26.95 |
| ADediting_1493988 | chrX_154011293_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-744-3p | chrX | 154011291 | 154011297 | 7mer-m8 | 154011290 | 154011310 | 141 | -10.73 |
| ADediting_1493988 | chrX_154011293_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-6501-5p | chrX | 154011291 | 154011297 | 7mer-1a | 154011291 | 154011312 | 140 | -26.95 |
| ADediting_1493988 | chrX_154011293_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-744-3p | chrX | 154011291 | 154011297 | 7mer-m8 | 154011290 | 154011310 | 141 | -10.73 |
| ADediting_1493989 | chrX_154011299_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-3064-5p | chrX | 154011298 | 154011304 | 7mer-m8 | 154011297 | 154011318 | 154 | -21.05 |
| ADediting_1493989 | chrX_154011299_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-3085-3p | chrX | 154011298 | 154011304 | 7mer-m8 | 154011297 | 154011317 | 153 | -21.59 |
| ADediting_1493989 | chrX_154011299_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-6504-5p | chrX | 154011298 | 154011304 | 7mer-m8 | 154011297 | 154011317 | 144 | -18.04 |
| ADediting_1493989 | chrX_154011299_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-874-3p | chrX | 154011293 | 154011300 | 8mer-1a | 154011293 | 154011315 | 151 | -24.9 |
| ADediting_1493989 | chrX_154011299_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-3064-5p | chrX | 154011298 | 154011304 | 7mer-m8 | 154011297 | 154011318 | 154 | -21.05 |
| ADediting_1493989 | chrX_154011299_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-3085-3p | chrX | 154011298 | 154011304 | 7mer-m8 | 154011297 | 154011317 | 153 | -21.59 |
| ADediting_1493989 | chrX_154011299_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-6504-5p | chrX | 154011298 | 154011304 | 7mer-m8 | 154011297 | 154011317 | 144 | -18.04 |
| ADediting_1493989 | chrX_154011299_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-874-3p | chrX | 154011293 | 154011300 | 8mer-1a | 154011293 | 154011315 | 151 | -24.9 |
| ADediting_1493990 | chrX_154011309_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-192-5p | chrX | 154011308 | 154011315 | 8mer-1a | 154011308 | 154011328 | 144 | -16.84 |
| ADediting_1493990 | chrX_154011309_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-215-5p | chrX | 154011308 | 154011315 | 8mer-1a | 154011308 | 154011328 | 144 | -15.96 |
| ADediting_1493990 | chrX_154011309_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-192-5p | chrX | 154011308 | 154011315 | 8mer-1a | 154011308 | 154011328 | 144 | -16.84 |
| ADediting_1493990 | chrX_154011309_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-215-5p | chrX | 154011308 | 154011315 | 8mer-1a | 154011308 | 154011328 | 144 | -15.96 |
| ADediting_1493991 | chrX_154011336_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-1976 | chrX | 154011332 | 154011338 | 7mer-m8 | 154011331 | 154011352 | 152 | -25.54 |
| ADediting_1493991 | chrX_154011336_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-660-3p | chrX | 154011330 | 154011337 | 8mer-1a | 154011330 | 154011350 | 143 | -18.16 |
| ADediting_1493991 | chrX_154011336_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-6747-3p | chrX | 154011333 | 154011340 | 8mer-1a | 154011333 | 154011354 | 154 | -24.54 |
| ADediting_1493991 | chrX_154011336_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-1976 | chrX | 154011332 | 154011338 | 7mer-m8 | 154011331 | 154011352 | 152 | -25.54 |
| ADediting_1493991 | chrX_154011336_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-660-3p | chrX | 154011330 | 154011337 | 8mer-1a | 154011330 | 154011350 | 143 | -18.16 |
| ADediting_1493991 | chrX_154011336_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-6747-3p | chrX | 154011333 | 154011340 | 8mer-1a | 154011333 | 154011354 | 154 | -24.54 |
| ADediting_1493992 | chrX_154011341_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-6878-3p | chrX | 154011340 | 154011347 | 8mer-1a | 154011340 | 154011360 | 142 | -14.14 |
| ADediting_1493992 | chrX_154011341_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-6878-3p | chrX | 154011340 | 154011347 | 8mer-1a | 154011340 | 154011360 | 142 | -14.14 |
| ADediting_1493993 | chrX_154011362_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-10399-5p | chrX | 154011361 | 154011367 | 7mer-m8 | 154011360 | 154011381 | 144 | -11.2 |
| ADediting_1493993 | chrX_154011362_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-5089-5p | chrX | 154011357 | 154011363 | 7mer-m8 | 154011356 | 154011378 | 148 | -14.13 |
| ADediting_1493993 | chrX_154011362_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-6504-3p | chrX | 154011361 | 154011367 | 7mer-m8 | 154011360 | 154011381 | 148 | -14.35 |
| ADediting_1493993 | chrX_154011362_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-10399-5p | chrX | 154011361 | 154011367 | 7mer-m8 | 154011360 | 154011381 | 144 | -11.2 |
| ADediting_1493993 | chrX_154011362_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-5089-5p | chrX | 154011357 | 154011363 | 7mer-m8 | 154011356 | 154011378 | 148 | -14.13 |
| ADediting_1493993 | chrX_154011362_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-6504-3p | chrX | 154011361 | 154011367 | 7mer-m8 | 154011360 | 154011381 | 148 | -14.35 |
| ADediting_1594969 | chrX_154011137_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-143-5p | chrX | 154011136 | 154011142 | 7mer-m8 | 154011135 | 154011156 | 152 | -17.91 |
| ADediting_1594969 | chrX_154011137_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-504-3p | chrX | 154011132 | 154011139 | 8mer-1a | 154011132 | 154011152 | 150 | -21.68 |
| ADediting_1594969 | chrX_154011137_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-143-5p | chrX | 154011136 | 154011142 | 7mer-m8 | 154011135 | 154011156 | 152 | -17.91 |
| ADediting_1594969 | chrX_154011137_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-504-3p | chrX | 154011132 | 154011139 | 8mer-1a | 154011132 | 154011152 | 150 | -21.68 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_291761 | chr11_93733708_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-1304-3p | chrX | 154010772 | 154010779 | 8mer-1a | 154010772 | 154010793 | 145 | -16.77 |
| ADediting_291761 | chr11_93733708_- | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-1304-3p | chrX | 154011624 | 154011630 | 7mer-m8 | 154011623 | 154011645 | 143 | -19.86 |
| ADediting_291761 | chr11_93733708_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-1304-3p | chrX | 154010772 | 154010779 | 8mer-1a | 154010772 | 154010793 | 145 | -16.77 |
| ADediting_291761 | chr11_93733708_- | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-1304-3p | chrX | 154011624 | 154011630 | 7mer-m8 | 154011623 | 154011645 | 143 | -19.86 |
| ADediting_291761 | chr11_93733708_- | ENSG00000184216.14 | ENST00000444230.5 | IRAK1-208 | hsa-miR-1304-3p | chrX | 154010772 | 154010779 | 8mer-1a | 154010772 | 154010793 | 145 | -16.77 |
| ADediting_291761 | chr11_93733708_- | ENSG00000184216.14 | ENST00000455690.5 | IRAK1-210 | hsa-miR-1304-3p | chrX | 154011624 | 154011630 | 7mer-m8 | 154011623 | 154011645 | 143 | -19.86 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000184216.14 | ENST00000369974.6 | IRAK1-202 | hsa-miR-1273h-3p | chrX | 154011503 | 154011509 | 7mer-m8 | 154011502 | 154011521 | 146 | -22.28 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000184216.14 | ENST00000369980.8 | IRAK1-203 | hsa-miR-1273h-3p | chrX | 154011503 | 154011509 | 7mer-m8 | 154011502 | 154011521 | 146 | -22.28 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for IRAK1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000369974.6 | protein_coding |  |  |
| ENST00000369980.8 | protein_coding |  |  |
| ENST00000444230.5 | protein_coding |  |  |
| ENST00000455690.5 | protein_coding |  |  |
| ENST00000444254.1 | protein_coding |  |  |
| ENST00000393687.6 | protein_coding |  |  |
| ENST00000429936.6 | protein_coding |  |  |
| ENST00000443220.1 | protein_coding |  |  |
| ENST00000467236.1 | lncRNA |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1493984 | ENST00000369974.6 | chrX_154011115_- | 2710 | -1486.30 | -1484.90 | -1503.60 |
| ADediting_1594969 | ENST00000369974.6 | chrX_154011137_- | 2688 | -1484.50 | -1484.90 | -1503.60 |
| ADediting_1493985 | ENST00000369974.6 | chrX_154011199_- | 2626 | -1491.30 | -1484.90 | -1503.60 |
| ADediting_1493986 | ENST00000369974.6 | chrX_154011217_- | 2608 | -1484.90 | -1484.90 | -1503.60 |
| ADediting_1493987 | ENST00000369974.6 | chrX_154011236_- | 2589 | -1485.30 | -1484.90 | -1503.60 |
| ADediting_1493988 | ENST00000369974.6 | chrX_154011293_- | 2532 | -1484.90 | -1484.90 | -1503.60 |
| ADediting_1493989 | ENST00000369974.6 | chrX_154011299_- | 2526 | -1486.10 | -1484.90 | -1503.60 |
| ADediting_1594970 | ENST00000369974.6 | chrX_154011308_- | 2517 | -1484.90 | -1484.90 | -1503.60 |
| ADediting_1493990 | ENST00000369974.6 | chrX_154011309_- | 2516 | -1484.90 | -1484.90 | -1503.60 |
| ADediting_1493991 | ENST00000369974.6 | chrX_154011336_- | 2489 | -1484.50 | -1484.90 | -1503.60 |
| ADediting_1594971 | ENST00000369974.6 | chrX_154011340_- | 2485 | -1484.40 | -1484.90 | -1503.60 |
| ADediting_1493992 | ENST00000369974.6 | chrX_154011341_- | 2484 | -1488.40 | -1484.90 | -1503.60 |
| ADediting_1493993 | ENST00000369974.6 | chrX_154011362_- | 2463 | -1484.90 | -1484.90 | -1503.60 |
| ADediting_1493984 | ENST00000369980.8 | chrX_154011115_- | 2973 | -1633.50 | -1632.10 | -1655.70 |
| ADediting_1594969 | ENST00000369980.8 | chrX_154011137_- | 2951 | -1631.70 | -1632.10 | -1655.70 |
| ADediting_1493985 | ENST00000369980.8 | chrX_154011199_- | 2889 | -1638.50 | -1632.10 | -1655.70 |
| ADediting_1493986 | ENST00000369980.8 | chrX_154011217_- | 2871 | -1632.10 | -1632.10 | -1655.70 |
| ADediting_1493987 | ENST00000369980.8 | chrX_154011236_- | 2852 | -1632.50 | -1632.10 | -1655.70 |
| ADediting_1493988 | ENST00000369980.8 | chrX_154011293_- | 2795 | -1632.10 | -1632.10 | -1655.70 |
| ADediting_1493989 | ENST00000369980.8 | chrX_154011299_- | 2789 | -1633.30 | -1632.10 | -1655.70 |
| ADediting_1594970 | ENST00000369980.8 | chrX_154011308_- | 2780 | -1632.10 | -1632.10 | -1655.70 |
| ADediting_1493990 | ENST00000369980.8 | chrX_154011309_- | 2779 | -1632.10 | -1632.10 | -1655.70 |
| ADediting_1493991 | ENST00000369980.8 | chrX_154011336_- | 2752 | -1631.40 | -1632.10 | -1655.70 |
| ADediting_1594971 | ENST00000369980.8 | chrX_154011340_- | 2748 | -1631.60 | -1632.10 | -1655.70 |
| ADediting_1493992 | ENST00000369980.8 | chrX_154011341_- | 2747 | -1635.60 | -1632.10 | -1655.70 |
| ADediting_1493993 | ENST00000369980.8 | chrX_154011362_- | 2726 | -1632.10 | -1632.10 | -1655.70 |
| ADediting_1493995 | ENST00000369980.8 | chrX_154014151_- | 1520 | -1632.20 | -1632.10 | -1655.70 |
| ADediting_1493984 | ENST00000444230.5 | chrX_154011115_- | 530 | -436.20 | -436.90 | -436.20 |
| ADediting_1493995 | ENST00000455690.5 | chrX_154014151_- | 170 | -349.10 | -349.10 | -349.10 |
| ADediting_1493995 | ENST00000444254.1 | chrX_154014151_- | 96 | -393.10 | -393.00 | -393.10 |
| ADediting_1493995 | ENST00000393687.6 | chrX_154014151_- | 1430 | -946.00 | -945.20 | -946.00 |
| ADediting_1493995 | ENST00000429936.6 | chrX_154014151_- | 1508 | -1013.50 | -1012.70 | -1013.50 |
| ADediting_1493995 | ENST00000443220.1 | chrX_154014151_- | 675 | -551.20 | -551.10 | -551.20 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1493995 | ENST00000467236.1 | chrX_154014151_- | 227 | -193.00 | -192.90 | -193.00 |
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Relation with ADAR for IRAK1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| STG | ADediting_1493987 | chrX_154011236_- | 0.00409231961812172 | 0.310131109932036 | 0.00932787899167623 | 0.282101879650024 | 0.927949401601603 | 0.0100160218476033 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 8.14346575775888e-32 | 0.600931058596572 | 4.22432214126798e-20 | 0.489695942600115 | 9.78894079737868e-45 | 0.687672502113379 |
| AC | 5.52546156897012e-30 | 0.638080449269223 | 3.05173223519285e-15 | 0.471503336835895 | 4.79134659408759e-28 | 0.620930236211304 |
| PCC | 5.22670193080482e-14 | 0.509440958873107 | 1.64259907742434e-13 | 0.500635594256489 | 5.20573411240298e-06 | 0.322927566840877 |
| CER | 8.69305435942464e-06 | 0.354242987585247 | 0.000250210810496281 | 0.294797915361723 | 0.000126727608642983 | 0.307880502217179 |
| TCX | 4.47850300506201e-10 | 0.481416321982075 | 0.015140165494771 | 0.198016289387834 | 3.09205182935735e-05 | 0.33321311175947 |
| FP | 1.57554121978828e-07 | 0.380791676377809 | 0.0261279208034931 | 0.166724678191782 | 5.49681781107715e-08 | 0.393543732104665 |
| IFG | 0.00243091559585659 | 0.578878870426341 | 0.000324539310930928 | 0.660693218552582 | 0.264256075915174 | 0.232093962158637 |
| PG | 0.962227251410633 | 0.0034960744918561 | 0.794253215798119 | -0.0192501675812211 | 5.60715850213259e-07 | 0.357163884769823 |
| STG | 1.63142698397268e-05 | 0.451449136643989 | 0.0510592785215546 | 0.213606374335355 | 0.00185441367374414 | 0.334773173248195 |
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Relation with AD stages for IRAK1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| IFG | ADediting_1493984 | chrX_154011115_- | 0.0141781305132572 | 0.484209503533271 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 4.30363283767239e-08 | 0.501652148341617 |
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RelatedDrugs for IRAK1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| IRAK1 | P51617 | DB12010 | Fostamatinib | Interleukin-1 receptor-associated kinase 1 | small molecule | approved|investigational |
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RelatedDiseases for IRAK1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| IRAK1 | C3714756 | Intellectual Disability | 5 | GENOMICS_ENGLAND |
| IRAK1 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| IRAK1 | C0010054 | Coronary Arteriosclerosis | 1 | CTD_human |
| IRAK1 | C0178540 | Cerebral Hypoxia-Ischemia | 1 | CTD_human |
| IRAK1 | C0752304 | Hypoxic-Ischemic Encephalopathy | 1 | CTD_human |
| IRAK1 | C0752305 | Anoxic-Ischemic Encephalopathy | 1 | CTD_human |
| IRAK1 | C0752306 | Anoxia-Ischemia, Brain | 1 | CTD_human |
| IRAK1 | C0752307 | Anoxia-Ischemia, Cerebral | 1 | CTD_human |
| IRAK1 | C0752308 | Hypoxia-Ischemia, Brain | 1 | CTD_human |
| IRAK1 | C1956346 | Coronary Artery Disease | 1 | CTD_human |
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