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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

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The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

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Relation with ADAR

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Relation with AD stages

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Related drugs with this gene

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Related diseases with this gene


Gene summary for INSIG1

check button Gene summary
Gene informationGene symbol

INSIG1

Gene ID

3638

Gene nameinsulin induced gene 1
SynonymsCL6
Cytomap

7q36.3

Type of geneprotein-coding
Descriptioninsulin-induced gene 1 proteinINSIG-1 membrane protein
Modification date20200313
UniProtAcc

O15503,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
INSIG1

GO:0032933

SREBP signaling pathway

12242332

INSIG1

GO:0036316

SREBP-SCAP complex retention in endoplasmic reticulum

12202038

INSIG1

GO:0042632

cholesterol homeostasis

12202038

INSIG1

GO:0070862

negative regulation of protein exit from endoplasmic reticulum

12202038


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RNA A-to-I events for INSIG1

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1319474(155304882, +), ADediting_1319475(155304952, +), ADediting_1319476(155304954, +), ADediting_1319477(155305019, +), ADediting_1319478(155305025, +), ADediting_1319479(155305052, +), ADediting_1319480(155305088, +), ADediting_1319481(155306017, +), ADediting_1319482(155306046, +), ADediting_1319483(155306047, +), ADediting_1319484(155306048, +), ADediting_1319485(155306062, +), ADediting_1319486(155306093, +), ADediting_1319487(155306117, +), ADediting_1319488(155306126, +), ADediting_1319489(155306139, +), ADediting_1319490(155306141, +), ADediting_1319491(155306200, +), ADediting_1319492(155306243, +), ADediting_1319493(155306262, +), ADediting_1586514(155306152, +),

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RNA editing positional annotations for INSIG1 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1319474chr7_155304882_+intronic
ADediting_1319475chr7_155304952_+intronic
ADediting_1319476chr7_155304954_+intronic
ADediting_1319477chr7_155305019_+intronic
ADediting_1319478chr7_155305025_+intronic
ADediting_1319479chr7_155305052_+intronic
ADediting_1319480chr7_155305088_+intronic
ADediting_1319481chr7_155306017_+intronic
ADediting_1319482chr7_155306046_+intronic
ADediting_1319483chr7_155306047_+intronic
ADediting_1319484chr7_155306048_+intronic
ADediting_1319485chr7_155306062_+intronic
ADediting_1319486chr7_155306093_+intronic
ADediting_1319487chr7_155306117_+intronic
ADediting_1319488chr7_155306126_+intronic
ADediting_1319489chr7_155306139_+intronic
ADediting_1319490chr7_155306141_+intronic
ADediting_1319491chr7_155306200_+intronic
ADediting_1319492chr7_155306243_+intronic
ADediting_1319493chr7_155306262_+intronic
ADediting_1586514chr7_155306152_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1319474chr7_155304882_+SINEAluName=AluYj4
ADediting_1319475chr7_155304952_+SINEAluName=AluYj4
ADediting_1319476chr7_155304954_+SINEAluName=AluYj4
ADediting_1319477chr7_155305019_+SINEAluName=AluYj4
ADediting_1319478chr7_155305025_+SINEAluName=AluYj4
ADediting_1319479chr7_155305052_+SINEAluName=AluYj4
ADediting_1319480chr7_155305088_+SINEAluName=AluYj4
ADediting_1319481chr7_155306017_+SINEAluName=AluSx1
ADediting_1319482chr7_155306046_+SINEAluName=AluSx1
ADediting_1319483chr7_155306047_+SINEAluName=AluSx1
ADediting_1319484chr7_155306048_+SINEAluName=AluSx1
ADediting_1319485chr7_155306062_+SINEAluName=AluSx1
ADediting_1319486chr7_155306093_+SINEAluName=AluSx1
ADediting_1319487chr7_155306117_+SINEAluName=AluSx1
ADediting_1319488chr7_155306126_+SINEAluName=AluSx1
ADediting_1319489chr7_155306139_+SINEAluName=AluSx1
ADediting_1319490chr7_155306141_+SINEAluName=AluSx1
ADediting_1319491chr7_155306200_+SINEAluName=AluSx1
ADediting_1319492chr7_155306243_+SINEAluName=AluSx1
ADediting_1319493chr7_155306262_+SINEAluName=AluSx1
ADediting_1586514chr7_155306152_+SINEAluName=AluSx1

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RNA A-to-I editing events in the alternative splicing sites for INSIG1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for INSIG1

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for INSIG1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for INSIG1


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337758chr7_5495892_-ENSG00000186480.13ENST00000340368.9INSIG1-201hsa-miR-589-5pchr71553089601553089678mer-1a155308946155308967158-19.45
ADediting_1337758chr7_5495892_-ENSG00000186480.13ENST00000344756.8INSIG1-203hsa-miR-589-5pchr71553089601553089678mer-1a155308946155308967158-19.45
ADediting_1535951chr14_100874558_+ENSG00000186480.13ENST00000340368.9INSIG1-201hsa-miR-337-3pchr71553097711553097788mer-1a155309757155309778149-9.03
ADediting_1535951chr14_100874558_+ENSG00000186480.13ENST00000344756.8INSIG1-203hsa-miR-337-3pchr71553097711553097788mer-1a155309757155309778149-9.03
ADediting_291761chr11_93733708_-ENSG00000186480.13ENST00000340368.9INSIG1-201hsa-miR-1304-3pchr71553099231553099297mer-m8155309908155309930149-15.2
ADediting_291761chr11_93733708_-ENSG00000186480.13ENST00000344756.8INSIG1-203hsa-miR-1304-3pchr71553099231553099297mer-m8155309908155309930149-15.2
ADediting_98289chr1_32086992_+ENSG00000186480.13ENST00000340368.9INSIG1-201hsa-miR-5585-3pchr71553093821553093887mer-m8155309370155309389145-12.89
ADediting_98289chr1_32086992_+ENSG00000186480.13ENST00000344756.8INSIG1-203hsa-miR-5585-3pchr71553093821553093887mer-m8155309370155309389145-12.89

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000186480.13ENST00000340368.9INSIG1-201hsa-miR-5688chr71553090821553090887mer-m8155309068155309089146-9.66
ADediting_1097295chr3_85385762_+ENSG00000186480.13ENST00000340368.9INSIG1-201hsa-miR-5688chr71553095591553095657mer-m8155309540155309566152-13.57
ADediting_1097295chr3_85385762_+ENSG00000186480.13ENST00000344756.8INSIG1-203hsa-miR-5688chr71553090821553090887mer-m8155309068155309089146-9.66
ADediting_1097295chr3_85385762_+ENSG00000186480.13ENST00000344756.8INSIG1-203hsa-miR-5688chr71553095591553095657mer-m8155309540155309566152-13.57
ADediting_1337758chr7_5495892_-ENSG00000186480.13ENST00000340368.9INSIG1-201hsa-miR-589-5pchr71553093761553093827mer-m8155309362155309383146-19.29
ADediting_1337758chr7_5495892_-ENSG00000186480.13ENST00000344756.8INSIG1-203hsa-miR-589-5pchr71553093761553093827mer-m8155309362155309383146-19.29
ADediting_1535953chr14_101045971_+ENSG00000186480.13ENST00000340368.9INSIG1-201hsa-miR-381-3pchr71553093241553093307mer-m8155309310155309331148-11.69
ADediting_1535953chr14_101045971_+ENSG00000186480.13ENST00000344756.8INSIG1-203hsa-miR-381-3pchr71553093241553093307mer-m8155309310155309331148-11.69
ADediting_1535954chr14_101045974_+ENSG00000186480.13ENST00000340368.9INSIG1-201hsa-miR-381-3pchr71553093241553093307mer-m8155309310155309331148-11.69
ADediting_1535954chr14_101045974_+ENSG00000186480.13ENST00000344756.8INSIG1-203hsa-miR-381-3pchr71553093241553093307mer-m8155309310155309331148-11.69
ADediting_1556067chr19_40282625_-ENSG00000186480.13ENST00000340368.9INSIG1-201hsa-miR-641chr71553097291553097357mer-m8155309713155309736140-13.83
ADediting_1556067chr19_40282625_-ENSG00000186480.13ENST00000344756.8INSIG1-203hsa-miR-641chr71553097291553097357mer-m8155309713155309736140-13.83
ADediting_1631458chr19_40282624_-ENSG00000186480.13ENST00000340368.9INSIG1-201hsa-miR-641chr71553097291553097357mer-m8155309713155309736140-13.83
ADediting_1631458chr19_40282624_-ENSG00000186480.13ENST00000344756.8INSIG1-203hsa-miR-641chr71553097291553097357mer-m8155309713155309736140-13.83

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for INSIG1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for INSIG1

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_1319482chr7_155306046_+0.03212201108809880.1217466609225080.971774354893790.00201776757091217.75674996915631e-100.340188569699627
DLPFCADediting_1319483chr7_155306047_+0.002862691440399850.1688369756176270.3514612761833750.05309749462846253.62896424445267e-100.346383044089623
DLPFCADediting_1319486chr7_155306093_+0.02322407406900360.128894415101690.4131799144182270.04664002952382212.94610242008997e-080.308447326237594
DLPFCADediting_1319489chr7_155306139_+0.5280621722648190.03597022314882790.363963073100262-0.05173627646184427.00464099192408e-080.300308060623356

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC1.4790801655887e-490.7137456555977631.81038453818836e-340.6211564595597036.74868283754218e-060.252530466851855
AC3.92075283688798e-730.8563423414464149.55355867538137e-590.8073528953059715.02571608458409e-100.380308950267625
PCC5.97769781955152e-230.6349389474992416.1892038999784e-270.6767700536208710.06149001760994740.135569801890742
CER3.53035682622799e-160.6023269244369524.24708598701343e-120.5270577639587420.3751899308270330.0729199656052256
TCX2.3650748246918e-160.6051439802259850.0001138844158432060.3098807950982860.0006827526920068580.27427278896138
FP3.40684403254248e-060.3400921693016992.24777128449019e-110.4743676125423760.08303783865403070.130281804646879
PG8.65593385915883e-380.7702374933501523.46885975438533e-130.500529510524040.09980933251875580.121046218153335
STG5.69171854173649e-090.5835457719308011.58738421949729e-060.4961962701689680.1088385100281680.17621756190832

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Relation with AD stages for INSIG1

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.

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RelatedDrugs for INSIG1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for INSIG1

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
INSIG1C0007097Carcinoma1CTD_human
INSIG1C0024667Animal Mammary Neoplasms1CTD_human
INSIG1C0024668Mammary Neoplasms, Experimental1CTD_human
INSIG1C0205696Anaplastic carcinoma1CTD_human
INSIG1C0205697Carcinoma, Spindle-Cell1CTD_human
INSIG1C0205698Undifferentiated carcinoma1CTD_human
INSIG1C0205699Carcinomatosis1CTD_human
INSIG1C1257925Mammary Carcinoma, Animal1CTD_human