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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for WDR86 |
 Gene summary |
| Gene information | Gene symbol | WDR86 | Gene ID | 349136 |
| Gene name | WD repeat domain 86 | |
| Synonyms | - | |
| Cytomap | 7q36.1 | |
| Type of gene | protein-coding | |
| Description | WD repeat-containing protein 86 | |
| Modification date | 20200313 | |
| UniProtAcc | Q86TI4, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for WDR86 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1316681(151383100, -), ADediting_1316682(151383110, -), ADediting_1316683(151383214, -), ADediting_1316684(151383374, -), ADediting_1316685(151383391, -), ADediting_1316686(151383516, -), ADediting_1316687(151383567, -), ADediting_1316688(151383568, -), ADediting_1316689(151383572, -), ADediting_1316690(151383573, -), ADediting_1316691(151383581, -), ADediting_1316692(151383589, -), ADediting_1316693(151383590, -), ADediting_1316694(151383598, -), ADediting_1316695(151400418, -), ADediting_1316696(151400447, -), ADediting_1316697(151400454, -), ADediting_1316698(151400458, -), ADediting_1316699(151400467, -), ADediting_1316700(151400478, -), ADediting_1316701(151400479, -), ADediting_1316702(151400484, -), ADediting_1316703(151400655, -), ADediting_1316704(151400656, -), ADediting_1316705(151400672, -), ADediting_1316706(151401793, -), ADediting_1316707(151401796, -), ADediting_1316708(151401805, -), ADediting_1316709(151401962, -), ADediting_1316710(151401965, -), ADediting_1316711(151401986, -), ADediting_1316712(151407582, -), ADediting_1316713(151407617, -), ADediting_1316714(151407622, -), ADediting_1316715(151407627, -), ADediting_1316716(151407647, -), ADediting_1316717(151407656, -), ADediting_1316718(151407673, -), ADediting_1316719(151407676, -), ADediting_1316720(151407693, -), ADediting_1316721(151407717, -), ADediting_1316722(151407719, -), ADediting_1316723(151407729, -), ADediting_1316724(151407731, -), ADediting_1316725(151407758, -), ADediting_1316726(151407759, -), ADediting_1316727(151407778, -), ADediting_1316728(151407794, -), ADediting_1316729(151407840, -), ADediting_1316730(151408264, -), ADediting_1316731(151408282, -), ADediting_1316732(151408289, -), ADediting_1316733(151408299, -), ADediting_1316734(151408302, -), ADediting_1316735(151408334, -), ADediting_1316736(151408335, -), ADediting_1316737(151408361, -), ADediting_1316738(151408368, -), ADediting_1316739(151408371, -), ADediting_1316740(151408376, -), ADediting_1316741(151408377, -), ADediting_1316742(151408391, -), ADediting_1316743(151408401, -), ADediting_1316744(151408411, -), ADediting_1316745(151408414, -), ADediting_1316746(151408425, -), ADediting_1316747(151408432, -), ADediting_1316748(151408435, -), ADediting_1316749(151408448, -), ADediting_1316750(151408464, -), ADediting_1316751(151408470, -), ADediting_1316752(151408471, -), ADediting_1316753(151408493, -), ADediting_1586380(151383078, -), ADediting_1586381(151383302, -), ADediting_1586382(151383366, -), |
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RNA editing positional annotations for WDR86 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1316681 | chr7_151383100_- | intronic |
| ADediting_1316682 | chr7_151383110_- | intronic |
| ADediting_1316683 | chr7_151383214_- | intronic |
| ADediting_1316684 | chr7_151383374_- | intronic |
| ADediting_1316685 | chr7_151383391_- | intronic |
| ADediting_1316686 | chr7_151383516_- | intronic |
| ADediting_1316687 | chr7_151383567_- | intronic |
| ADediting_1316688 | chr7_151383568_- | intronic |
| ADediting_1316689 | chr7_151383572_- | intronic |
| ADediting_1316690 | chr7_151383573_- | intronic |
| ADediting_1316691 | chr7_151383581_- | intronic |
| ADediting_1316692 | chr7_151383589_- | intronic |
| ADediting_1316693 | chr7_151383590_- | intronic |
| ADediting_1316694 | chr7_151383598_- | intronic |
| ADediting_1316695 | chr7_151400418_- | intronic |
| ADediting_1316696 | chr7_151400447_- | intronic |
| ADediting_1316697 | chr7_151400454_- | intronic |
| ADediting_1316698 | chr7_151400458_- | intronic |
| ADediting_1316699 | chr7_151400467_- | intronic |
| ADediting_1316700 | chr7_151400478_- | intronic |
| ADediting_1316701 | chr7_151400479_- | intronic |
| ADediting_1316702 | chr7_151400484_- | intronic |
| ADediting_1316703 | chr7_151400655_- | intronic |
| ADediting_1316704 | chr7_151400656_- | intronic |
| ADediting_1316705 | chr7_151400672_- | intronic |
| ADediting_1316706 | chr7_151401793_- | intronic |
| ADediting_1316707 | chr7_151401796_- | intronic |
| ADediting_1316708 | chr7_151401805_- | intronic |
| ADediting_1316709 | chr7_151401962_- | intronic |
| ADediting_1316710 | chr7_151401965_- | intronic |
| ADediting_1316711 | chr7_151401986_- | intronic |
| ADediting_1316712 | chr7_151407582_- | intronic |
| ADediting_1316713 | chr7_151407617_- | intronic |
| ADediting_1316714 | chr7_151407622_- | intronic |
| ADediting_1316715 | chr7_151407627_- | intronic |
| ADediting_1316716 | chr7_151407647_- | intronic |
| ADediting_1316717 | chr7_151407656_- | intronic |
| ADediting_1316718 | chr7_151407673_- | intronic |
| ADediting_1316719 | chr7_151407676_- | intronic |
| ADediting_1316720 | chr7_151407693_- | intronic |
| ADediting_1316721 | chr7_151407717_- | intronic |
| ADediting_1316722 | chr7_151407719_- | intronic |
| ADediting_1316723 | chr7_151407729_- | intronic |
| ADediting_1316724 | chr7_151407731_- | intronic |
| ADediting_1316725 | chr7_151407758_- | intronic |
| ADediting_1316726 | chr7_151407759_- | intronic |
| ADediting_1316727 | chr7_151407778_- | intronic |
| ADediting_1316728 | chr7_151407794_- | intronic |
| ADediting_1316729 | chr7_151407840_- | intronic |
| ADediting_1316730 | chr7_151408264_- | intronic |
| ADediting_1316731 | chr7_151408282_- | intronic |
| ADediting_1316732 | chr7_151408289_- | intronic |
| ADediting_1316733 | chr7_151408299_- | intronic |
| ADediting_1316734 | chr7_151408302_- | intronic |
| ADediting_1316735 | chr7_151408334_- | intronic |
| ADediting_1316736 | chr7_151408335_- | intronic |
| ADediting_1316737 | chr7_151408361_- | intronic |
| ADediting_1316738 | chr7_151408368_- | intronic |
| ADediting_1316739 | chr7_151408371_- | intronic |
| ADediting_1316740 | chr7_151408376_- | intronic |
| ADediting_1316741 | chr7_151408377_- | intronic |
| ADediting_1316742 | chr7_151408391_- | intronic |
| ADediting_1316743 | chr7_151408401_- | intronic |
| ADediting_1316744 | chr7_151408411_- | intronic |
| ADediting_1316745 | chr7_151408414_- | intronic |
| ADediting_1316746 | chr7_151408425_- | intronic |
| ADediting_1316747 | chr7_151408432_- | intronic |
| ADediting_1316748 | chr7_151408435_- | intronic |
| ADediting_1316749 | chr7_151408448_- | intronic |
| ADediting_1316750 | chr7_151408464_- | intronic |
| ADediting_1316751 | chr7_151408470_- | intronic |
| ADediting_1316752 | chr7_151408471_- | intronic |
| ADediting_1316753 | chr7_151408493_- | intronic |
| ADediting_1586380 | chr7_151383078_- | intronic |
| ADediting_1586381 | chr7_151383302_- | intronic |
| ADediting_1586382 | chr7_151383366_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1316681 | chr7_151383100_- | SINE | Alu | Name=AluJr4 |
| ADediting_1316682 | chr7_151383110_- | SINE | Alu | Name=AluJr4 |
| ADediting_1316683 | chr7_151383214_- | SINE | Alu | Name=AluSg |
| ADediting_1316684 | chr7_151383374_- | SINE | Alu | Name=AluSg |
| ADediting_1316685 | chr7_151383391_- | SINE | Alu | Name=AluSg |
| ADediting_1316686 | chr7_151383516_- | SINE | Alu | Name=AluJr4 |
| ADediting_1316687 | chr7_151383567_- | SINE | Alu | Name=AluJr4 |
| ADediting_1316688 | chr7_151383568_- | SINE | Alu | Name=AluJr4 |
| ADediting_1316689 | chr7_151383572_- | SINE | Alu | Name=AluJr4 |
| ADediting_1316690 | chr7_151383573_- | SINE | Alu | Name=AluJr4 |
| ADediting_1316691 | chr7_151383581_- | SINE | Alu | Name=AluJr4 |
| ADediting_1316692 | chr7_151383589_- | SINE | Alu | Name=AluJr4 |
| ADediting_1316693 | chr7_151383590_- | SINE | Alu | Name=AluJr4 |
| ADediting_1316694 | chr7_151383598_- | SINE | Alu | Name=AluJr4 |
| ADediting_1316695 | chr7_151400418_- | SINE | Alu | Name=AluSz |
| ADediting_1316696 | chr7_151400447_- | SINE | Alu | Name=AluSz |
| ADediting_1316697 | chr7_151400454_- | SINE | Alu | Name=AluSz |
| ADediting_1316698 | chr7_151400458_- | SINE | Alu | Name=AluSz |
| ADediting_1316699 | chr7_151400467_- | SINE | Alu | Name=AluSz |
| ADediting_1316700 | chr7_151400478_- | SINE | Alu | Name=AluSz |
| ADediting_1316701 | chr7_151400479_- | SINE | Alu | Name=AluSz |
| ADediting_1316702 | chr7_151400484_- | SINE | Alu | Name=AluSz |
| ADediting_1316703 | chr7_151400655_- | SINE | Alu | Name=AluSz |
| ADediting_1316704 | chr7_151400656_- | SINE | Alu | Name=AluSz |
| ADediting_1316705 | chr7_151400672_- | SINE | Alu | Name=AluSz |
| ADediting_1316706 | chr7_151401793_- | SINE | Alu | Name=AluSg7 |
| ADediting_1316707 | chr7_151401796_- | SINE | Alu | Name=AluSg7 |
| ADediting_1316708 | chr7_151401805_- | SINE | Alu | Name=AluSg7 |
| ADediting_1316709 | chr7_151401962_- | SINE | Alu | Name=AluSg7 |
| ADediting_1316710 | chr7_151401965_- | SINE | Alu | Name=AluSg7 |
| ADediting_1316711 | chr7_151401986_- | SINE | Alu | Name=AluSg7 |
| ADediting_1316712 | chr7_151407582_- | SINE | Alu | Name=AluSq |
| ADediting_1316713 | chr7_151407617_- | SINE | Alu | Name=AluSq |
| ADediting_1316714 | chr7_151407622_- | SINE | Alu | Name=AluSq |
| ADediting_1316715 | chr7_151407627_- | SINE | Alu | Name=AluSq |
| ADediting_1316716 | chr7_151407647_- | SINE | Alu | Name=AluSq |
| ADediting_1316717 | chr7_151407656_- | SINE | Alu | Name=AluSq |
| ADediting_1316718 | chr7_151407673_- | SINE | Alu | Name=AluSq |
| ADediting_1316719 | chr7_151407676_- | SINE | Alu | Name=AluSq |
| ADediting_1316720 | chr7_151407693_- | SINE | Alu | Name=AluSq |
| ADediting_1316721 | chr7_151407717_- | SINE | Alu | Name=AluSq |
| ADediting_1316722 | chr7_151407719_- | SINE | Alu | Name=AluSq |
| ADediting_1316723 | chr7_151407729_- | SINE | Alu | Name=AluSq |
| ADediting_1316724 | chr7_151407731_- | SINE | Alu | Name=AluSq |
| ADediting_1316725 | chr7_151407758_- | SINE | Alu | Name=AluSq |
| ADediting_1316726 | chr7_151407759_- | SINE | Alu | Name=AluSq |
| ADediting_1316727 | chr7_151407778_- | SINE | Alu | Name=AluSq |
| ADediting_1316728 | chr7_151407794_- | SINE | Alu | Name=AluSq |
| ADediting_1316729 | chr7_151407840_- | SINE | Alu | Name=AluSq |
| ADediting_1316730 | chr7_151408264_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316731 | chr7_151408282_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316732 | chr7_151408289_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316733 | chr7_151408299_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316734 | chr7_151408302_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316735 | chr7_151408334_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316736 | chr7_151408335_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316737 | chr7_151408361_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316738 | chr7_151408368_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316739 | chr7_151408371_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316740 | chr7_151408376_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316741 | chr7_151408377_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316742 | chr7_151408391_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316743 | chr7_151408401_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316744 | chr7_151408411_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316745 | chr7_151408414_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316746 | chr7_151408425_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316747 | chr7_151408432_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316748 | chr7_151408435_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316749 | chr7_151408448_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316750 | chr7_151408464_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316751 | chr7_151408470_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316752 | chr7_151408471_- | SINE | Alu | Name=AluSx1 |
| ADediting_1316753 | chr7_151408493_- | SINE | Alu | Name=AluSx1 |
| ADediting_1586380 | chr7_151383078_- | SINE | Alu | Name=AluJr4 |
| ADediting_1586381 | chr7_151383302_- | SINE | Alu | Name=AluSg |
| ADediting_1586382 | chr7_151383366_- | SINE | Alu | Name=AluSg |
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RNA A-to-I editing events in the alternative splicing sites for WDR86 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for WDR86 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for WDR86 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for WDR86 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for WDR86 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for WDR86 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_1316716 | chr7_151407647_- | 0.346195476695923 | 0.0536799596796551 | 0.684880979028637 | -0.0231389437807084 | 1.84327033343736e-09 | 0.332959303626182 |
| DLPFC | ADediting_1316724 | chr7_151407731_- | 0.812611277842938 | 0.0135180218029446 | 0.106391884951923 | -0.0918816498013417 | 4.37480805849255e-12 | 0.379972387032212 |
| DLPFC | ADediting_1316737 | chr7_151408361_- | 0.00724224432480794 | 0.15225073672629 | 0.822991337636267 | 0.0127562783552364 | 1.06781249593556e-21 | 0.507517551095872 |
| DLPFC | ADediting_1316742 | chr7_151408391_- | 0.326897082094509 | 0.0558641979914845 | 0.28831377567398 | -0.0604969173105826 | 5.0023752256387e-19 | 0.477105875184297 |
| DLPFC | ADediting_1316746 | chr7_151408425_- | 0.962629368199666 | 0.00267193344329219 | 0.0957874290629262 | -0.094771161259051 | 1.66767870135784e-12 | 0.386815257934892 |
| DLPFC | ADediting_1316747 | chr7_151408432_- | 0.694865104237248 | -0.0223665165759444 | 0.0535770758267828 | -0.109742276169815 | 3.63684081305742e-12 | 0.381295616686042 |
| DLPFC | ADediting_1316748 | chr7_151408435_- | 0.441098531738339 | -0.0439086180106347 | 0.0343355772640223 | -0.120236272453342 | 6.41409325637129e-08 | 0.301147249234506 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 6.81913880042396e-14 | 0.408428568150338 | 1.69753529711296e-17 | 0.458204523054073 | 9.60501620225515e-15 | 0.42094586605219 |
| PCC | 1.49195906685728e-16 | 0.550897268983519 | 7.75761974281439e-13 | 0.48828022785785 | 0.0308396867498233 | 0.15629409627848 |
| CER | 6.00741046316487e-10 | 0.4782997322873 | 2.2565914477177e-21 | 0.676073252925394 | 6.40219258054424e-07 | 0.39329346163941 |
| FP | 4.03123808726871e-05 | 0.302619039102606 | 6.52588636036672e-05 | 0.294686418631678 | 0.000191753037300856 | 0.27604182803103 |
| IFG | 0.00943236432386174 | 0.508571071767627 | 4.87265941429082e-05 | 0.720465632330413 | 0.772038949854472 | 0.06101136514827 |
| STG | 0.000649813125460251 | 0.364620572162197 | 0.0381383320248163 | 0.226665566308496 | 0.000590861754106813 | 0.367190147059391 |
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Relation with AD stages for WDR86 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 2.10961353093157e-10 | 0.56379056265462 |
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RelatedDrugs for WDR86 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WDR86 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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