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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for IFNAR2

check button Gene summary
Gene informationGene symbol

IFNAR2

Gene ID

3455

Gene nameinterferon alpha and beta receptor subunit 2
SynonymsIFN-R|IFN-alpha-REC|IFNABR|IFNARB|IMD45
Cytomap

21q22.11

Type of geneprotein-coding
Descriptioninterferon alpha/beta receptor 2IFN-R-2IFN-alpha/beta receptor 2human interferon alpha/beta receptorinterferon (alpha, beta and omega) receptor 2interferon alpha binding proteininterferon receptorinterferon-alpha/beta receptor beta chaintype I int
Modification date20200313
UniProtAcc

P48551,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
IFNAR2

GO:0035455

response to interferon-alpha

7759950

IFNAR2

GO:0060337

type I interferon signaling pathway

7665574


Top

RNA A-to-I events for IFNAR2

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_956313(33231766, +), ADediting_956314(33231767, +), ADediting_956315(33231803, +), ADediting_956316(33231821, +), ADediting_956317(33231822, +), ADediting_956318(33231842, +), ADediting_956319(33231871, +), ADediting_956320(33231876, +), ADediting_956321(33231881, +), ADediting_956322(33231883, +), ADediting_956323(33231919, +), ADediting_956324(33231922, +), ADediting_956325(33231940, +), ADediting_956326(33231945, +), ADediting_956327(33231949, +), ADediting_956328(33231976, +), ADediting_956329(33232002, +), ADediting_956330(33232008, +), ADediting_956331(33232014, +), ADediting_956332(33235739, +), ADediting_956333(33235805, +), ADediting_956334(33235811, +), ADediting_956335(33237323, +), ADediting_956336(33237414, +), ADediting_956337(33237455, +), ADediting_956338(33237460, +), ADediting_956339(33240544, +), ADediting_956340(33240557, +), ADediting_956341(33240559, +), ADediting_956342(33240565, +), ADediting_956343(33240566, +), ADediting_956344(33240571, +), ADediting_956345(33240609, +), ADediting_956346(33240614, +), ADediting_956347(33240623, +), ADediting_956348(33240624, +), ADediting_956349(33240626, +), ADediting_956350(33240628, +), ADediting_956351(33240639, +), ADediting_956352(33240668, +), ADediting_956353(33240680, +), ADediting_956354(33240683, +), ADediting_956355(33240685, +), ADediting_956356(33240695, +), ADediting_956357(33240705, +), ADediting_956358(33240709, +), ADediting_956359(33240717, +), ADediting_956360(33240735, +), ADediting_956361(33240772, +), ADediting_956362(33242477, +), ADediting_956363(33242478, +), ADediting_956364(33242504, +), ADediting_956365(33242521, +), ADediting_956366(33242545, +), ADediting_956367(33242576, +), ADediting_956368(33242579, +), ADediting_956369(33242583, +), ADediting_956370(33242586, +), ADediting_956371(33242612, +), ADediting_956372(33242618, +), ADediting_956373(33242653, +), ADediting_956374(33242654, +), ADediting_956375(33242713, +), ADediting_956376(33242716, +), ADediting_956377(33242809, +), ADediting_956378(33242821, +), ADediting_956379(33242858, +), ADediting_956380(33242868, +), ADediting_956381(33242888, +), ADediting_956382(33242889, +), ADediting_956383(33242893, +), ADediting_956384(33242915, +), ADediting_956385(33242918, +), ADediting_956386(33242928, +), ADediting_956387(33242930, +), ADediting_956388(33242969, +), ADediting_956389(33242972, +), ADediting_956390(33242978, +), ADediting_956391(33242979, +), ADediting_956392(33243048, +), ADediting_956393(33243051, +), ADediting_956394(33243062, +), ADediting_956395(33243107, +), ADediting_956396(33243123, +), ADediting_956397(33243135, +), ADediting_956398(33243152, +), ADediting_956399(33243200, +), ADediting_956400(33243209, +), ADediting_956401(33243212, +), ADediting_956402(33243232, +), ADediting_956403(33243235, +), ADediting_956404(33243240, +), ADediting_956405(33243244, +), ADediting_956406(33243258, +), ADediting_956407(33243264, +), ADediting_956408(33243267, +), ADediting_956409(33243273, +), ADediting_956410(33243312, +), ADediting_956411(33243330, +), ADediting_956412(33243345, +), ADediting_956413(33243357, +), ADediting_956414(33249086, +), ADediting_956415(33249088, +), ADediting_956416(33249089, +), ADediting_956417(33249173, +), ADediting_956418(33249213, +), ADediting_956419(33249223, +), ADediting_956420(33249264, +), ADediting_956421(33249265, +), ADediting_956422(33249269, +), ADediting_956423(33249276, +), ADediting_956424(33250556, +), ADediting_956425(33250618, +), ADediting_956426(33250664, +), ADediting_956427(33250667, +), ADediting_956428(33250677, +), ADediting_956429(33250728, +), ADediting_956430(33250773, +), ADediting_956431(33250782, +), ADediting_956432(33250791, +), ADediting_956433(33250813, +), ADediting_956434(33250816, +), ADediting_956435(33250819, +), ADediting_956436(33251828, +), ADediting_956437(33251844, +), ADediting_956438(33251849, +), ADediting_956439(33251850, +), ADediting_956440(33251854, +), ADediting_956441(33251858, +), ADediting_956442(33251912, +), ADediting_956443(33251990, +), ADediting_956444(33252008, +), ADediting_956445(33261068, +), ADediting_956446(33261090, +), ADediting_956447(33261106, +), ADediting_956448(33261111, +), ADediting_956449(33261117, +), ADediting_956450(33261130, +), ADediting_956451(33261162, +), ADediting_956452(33261166, +), ADediting_956453(33261178, +), ADediting_956454(33261237, +), ADediting_956455(33261246, +), ADediting_956456(33261299, +), ADediting_956457(33261597, +), ADediting_956458(33261676, +), ADediting_956459(33261694, +), ADediting_956460(33261769, +), ADediting_956461(33261817, +), ADediting_956462(33261841, +), ADediting_956463(33261871, +), ADediting_956464(33262090, +), ADediting_956465(33262109, +), ADediting_956466(33262112, +), ADediting_956467(33262142, +), ADediting_956468(33262209, +), ADediting_956469(33262228, +), ADediting_956470(33262305, +), ADediting_956471(33262314, +), ADediting_956472(33262566, +), ADediting_956473(33262586, +), ADediting_956474(33262623, +), ADediting_956475(33262631, +), ADediting_956476(33262647, +), ADediting_956477(33262663, +), ADediting_956478(33262688, +), ADediting_1568806(33243248, +), ADediting_1568807(33262565, +), ADediting_1641768(33240587, +),

Top

RNA editing positional annotations for IFNAR2 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
ADediting_1568807chr21_33262565_+nonsynonymous SNVENST00000404220.7c.A845Gp.Q282R0.3040.009-0.48
ADediting_1568807chr21_33262565_+nonsynonymous SNVENST00000382264.7c.A845Gp.Q282R0.3040.009-0.48
ADediting_956472chr21_33262566_+synonymous SNVENST00000404220.7c.A846Gp.Q282Q...
ADediting_956472chr21_33262566_+synonymous SNVENST00000382264.7c.A846Gp.Q282Q...
ADediting_956473chr21_33262586_+nonsynonymous SNVENST00000404220.7c.A866Gp.N289S1.00.00.2
ADediting_956473chr21_33262586_+nonsynonymous SNVENST00000382264.7c.A866Gp.N289S1.00.00.2
ADediting_956474chr21_33262623_+synonymous SNVENST00000404220.7c.A903Gp.L301L...
ADediting_956474chr21_33262623_+synonymous SNVENST00000382264.7c.A903Gp.L301L...
ADediting_956475chr21_33262631_+nonsynonymous SNVENST00000404220.7c.A911Gp.E304G0.0130.023-1.77
ADediting_956475chr21_33262631_+nonsynonymous SNVENST00000382264.7c.A911Gp.E304G0.0130.023-1.77
ADediting_956476chr21_33262647_+synonymous SNVENST00000404220.7c.A927Gp.K309K...
ADediting_956476chr21_33262647_+synonymous SNVENST00000382264.7c.A927Gp.K309K...
ADediting_956477chr21_33262663_+nonsynonymous SNVENST00000404220.7c.A943Gp.S315G0.00.682-0.88
ADediting_956477chr21_33262663_+nonsynonymous SNVENST00000382264.7c.A943Gp.S315G0.00.682-0.88
ADediting_956478chr21_33262688_+nonsynonymous SNVENST00000404220.7c.A968Gp.K323R0.480.0-0.3
ADediting_956478chr21_33262688_+nonsynonymous SNVENST00000382264.7c.A968Gp.K323R0.480.0-0.3

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_956313chr21_33231766_+intronic
ADediting_956314chr21_33231767_+intronic
ADediting_956315chr21_33231803_+intronic
ADediting_956316chr21_33231821_+intronic
ADediting_956317chr21_33231822_+intronic
ADediting_956318chr21_33231842_+intronic
ADediting_956319chr21_33231871_+intronic
ADediting_956320chr21_33231876_+intronic
ADediting_956321chr21_33231881_+intronic
ADediting_956322chr21_33231883_+intronic
ADediting_956323chr21_33231919_+intronic
ADediting_956324chr21_33231922_+intronic
ADediting_956325chr21_33231940_+intronic
ADediting_956326chr21_33231945_+intronic
ADediting_956327chr21_33231949_+intronic
ADediting_956328chr21_33231976_+intronic
ADediting_956329chr21_33232002_+intronic
ADediting_956330chr21_33232008_+intronic
ADediting_956331chr21_33232014_+intronic
ADediting_956332chr21_33235739_+intronic
ADediting_956333chr21_33235805_+intronic
ADediting_956334chr21_33235811_+intronic
ADediting_956335chr21_33237323_+intronic
ADediting_956336chr21_33237414_+intronic
ADediting_956337chr21_33237455_+intronic
ADediting_956338chr21_33237460_+intronic
ADediting_956339chr21_33240544_+intronic
ADediting_956340chr21_33240557_+intronic
ADediting_956341chr21_33240559_+intronic
ADediting_956342chr21_33240565_+intronic
ADediting_956343chr21_33240566_+intronic
ADediting_956344chr21_33240571_+intronic
ADediting_956345chr21_33240609_+intronic
ADediting_956346chr21_33240614_+intronic
ADediting_956347chr21_33240623_+intronic
ADediting_956348chr21_33240624_+intronic
ADediting_956349chr21_33240626_+intronic
ADediting_956350chr21_33240628_+intronic
ADediting_956351chr21_33240639_+intronic
ADediting_956352chr21_33240668_+intronic
ADediting_956353chr21_33240680_+intronic
ADediting_956354chr21_33240683_+intronic
ADediting_956355chr21_33240685_+intronic
ADediting_956356chr21_33240695_+intronic
ADediting_956357chr21_33240705_+intronic
ADediting_956358chr21_33240709_+intronic
ADediting_956359chr21_33240717_+intronic
ADediting_956360chr21_33240735_+intronic
ADediting_956361chr21_33240772_+intronic
ADediting_956362chr21_33242477_+intronic
ADediting_956363chr21_33242478_+intronic
ADediting_956364chr21_33242504_+intronic
ADediting_956365chr21_33242521_+intronic
ADediting_956366chr21_33242545_+intronic
ADediting_956367chr21_33242576_+intronic
ADediting_956368chr21_33242579_+intronic
ADediting_956369chr21_33242583_+intronic
ADediting_956370chr21_33242586_+intronic
ADediting_956371chr21_33242612_+intronic
ADediting_956372chr21_33242618_+intronic
ADediting_956373chr21_33242653_+intronic
ADediting_956374chr21_33242654_+intronic
ADediting_956375chr21_33242713_+intronic
ADediting_956376chr21_33242716_+intronic
ADediting_956377chr21_33242809_+intronic
ADediting_956378chr21_33242821_+intronic
ADediting_956379chr21_33242858_+intronic
ADediting_956380chr21_33242868_+intronic
ADediting_956381chr21_33242888_+intronic
ADediting_956382chr21_33242889_+intronic
ADediting_956383chr21_33242893_+intronic
ADediting_956384chr21_33242915_+intronic
ADediting_956385chr21_33242918_+intronic
ADediting_956386chr21_33242928_+intronic
ADediting_956387chr21_33242930_+intronic
ADediting_956388chr21_33242969_+intronic
ADediting_956389chr21_33242972_+intronic
ADediting_956390chr21_33242978_+intronic
ADediting_956391chr21_33242979_+intronic
ADediting_956392chr21_33243048_+intronic
ADediting_956393chr21_33243051_+intronic
ADediting_956394chr21_33243062_+intronic
ADediting_956395chr21_33243107_+intronic
ADediting_956396chr21_33243123_+intronic
ADediting_956397chr21_33243135_+intronic
ADediting_956398chr21_33243152_+intronic
ADediting_956399chr21_33243200_+intronic
ADediting_956400chr21_33243209_+intronic
ADediting_956401chr21_33243212_+intronic
ADediting_956402chr21_33243232_+intronic
ADediting_956403chr21_33243235_+intronic
ADediting_956404chr21_33243240_+intronic
ADediting_956405chr21_33243244_+intronic
ADediting_956406chr21_33243258_+intronic
ADediting_956407chr21_33243264_+intronic
ADediting_956408chr21_33243267_+intronic
ADediting_956409chr21_33243273_+intronic
ADediting_956410chr21_33243312_+intronic
ADediting_956411chr21_33243330_+intronic
ADediting_956412chr21_33243345_+intronic
ADediting_956413chr21_33243357_+intronic
ADediting_956414chr21_33249086_+intronic
ADediting_956415chr21_33249088_+intronic
ADediting_956416chr21_33249089_+intronic
ADediting_956417chr21_33249173_+intronic
ADediting_956418chr21_33249213_+intronic
ADediting_956419chr21_33249223_+intronic
ADediting_956420chr21_33249264_+intronic
ADediting_956421chr21_33249265_+intronic
ADediting_956422chr21_33249269_+intronic
ADediting_956423chr21_33249276_+intronic
ADediting_956424chr21_33250556_+intronic
ADediting_956425chr21_33250618_+intronic
ADediting_956426chr21_33250664_+intronic
ADediting_956427chr21_33250667_+intronic
ADediting_956428chr21_33250677_+intronic
ADediting_956429chr21_33250728_+intronic
ADediting_956430chr21_33250773_+intronic
ADediting_956431chr21_33250782_+intronic
ADediting_956432chr21_33250791_+intronic
ADediting_956433chr21_33250813_+intronic
ADediting_956434chr21_33250816_+intronic
ADediting_956435chr21_33250819_+intronic
ADediting_956436chr21_33251828_+intronic
ADediting_956437chr21_33251844_+intronic
ADediting_956438chr21_33251849_+intronic
ADediting_956439chr21_33251850_+intronic
ADediting_956440chr21_33251854_+intronic
ADediting_956441chr21_33251858_+intronic
ADediting_956442chr21_33251912_+intronic
ADediting_956443chr21_33251990_+intronic
ADediting_956444chr21_33252008_+intronic
ADediting_956445chr21_33261068_+intronic
ADediting_956446chr21_33261090_+intronic
ADediting_956447chr21_33261106_+intronic
ADediting_956448chr21_33261111_+intronic
ADediting_956449chr21_33261117_+intronic
ADediting_956450chr21_33261130_+intronic
ADediting_956451chr21_33261162_+intronic
ADediting_956452chr21_33261166_+intronic
ADediting_956453chr21_33261178_+intronic
ADediting_956454chr21_33261237_+intronic
ADediting_956455chr21_33261246_+intronic
ADediting_956456chr21_33261299_+intronic
ADediting_956457chr21_33261597_+intronic
ADediting_956458chr21_33261676_+intronic
ADediting_956459chr21_33261694_+intronic
ADediting_956460chr21_33261769_+intronic
ADediting_956461chr21_33261817_+intronic
ADediting_956462chr21_33261841_+intronic
ADediting_956463chr21_33261871_+intronic
ADediting_956464chr21_33262090_+intronic
ADediting_956465chr21_33262109_+intronic
ADediting_956466chr21_33262112_+intronic
ADediting_956467chr21_33262142_+intronic
ADediting_956468chr21_33262209_+intronic
ADediting_956469chr21_33262228_+intronic
ADediting_956470chr21_33262305_+intronic
ADediting_956471chr21_33262314_+intronic
ADediting_956472chr21_33262566_+exonic
ADediting_956473chr21_33262586_+exonic
ADediting_956474chr21_33262623_+exonic
ADediting_956475chr21_33262631_+exonic
ADediting_956476chr21_33262647_+exonic
ADediting_956477chr21_33262663_+exonic
ADediting_956478chr21_33262688_+exonic
ADediting_1568806chr21_33243248_+intronic
ADediting_1568807chr21_33262565_+exonic
ADediting_1641768chr21_33240587_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_956313chr21_33231766_+SINEAluName=AluSz
ADediting_956314chr21_33231767_+SINEAluName=AluSz
ADediting_956315chr21_33231803_+SINEAluName=AluSz
ADediting_956316chr21_33231821_+SINEAluName=AluSz
ADediting_956317chr21_33231822_+SINEAluName=AluSz
ADediting_956318chr21_33231842_+SINEAluName=AluSz
ADediting_956319chr21_33231871_+SINEAluName=AluSz
ADediting_956320chr21_33231876_+SINEAluName=AluSz
ADediting_956321chr21_33231881_+SINEAluName=AluSz
ADediting_956322chr21_33231883_+SINEAluName=AluSz
ADediting_956323chr21_33231919_+SINEAluName=AluSz
ADediting_956324chr21_33231922_+SINEAluName=AluSz
ADediting_956325chr21_33231940_+SINEAluName=AluSz
ADediting_956326chr21_33231945_+SINEAluName=AluSz
ADediting_956327chr21_33231949_+SINEAluName=AluSz
ADediting_956328chr21_33231976_+SINEAluName=AluSz
ADediting_956329chr21_33232002_+SINEAluName=AluSz
ADediting_956330chr21_33232008_+SINEAluName=AluSz
ADediting_956331chr21_33232014_+SINEAluName=AluSz
ADediting_956332chr21_33235739_+SINEAluName=AluY
ADediting_956333chr21_33235805_+SINEAluName=AluY
ADediting_956334chr21_33235811_+SINEAluName=AluY
ADediting_956335chr21_33237323_+SINEAluName=AluJb
ADediting_956336chr21_33237414_+SINEAluName=AluJb
ADediting_956337chr21_33237455_+SINEAluName=AluJb
ADediting_956338chr21_33237460_+SINEAluName=AluJb
ADediting_956339chr21_33240544_+SINEAluName=AluJb
ADediting_956340chr21_33240557_+SINEAluName=AluJb
ADediting_956341chr21_33240559_+SINEAluName=AluJb
ADediting_956342chr21_33240565_+SINEAluName=AluJb
ADediting_956343chr21_33240566_+SINEAluName=AluJb
ADediting_956344chr21_33240571_+SINEAluName=AluJb
ADediting_956345chr21_33240609_+SINEAluName=AluJb
ADediting_956346chr21_33240614_+SINEAluName=AluJb
ADediting_956347chr21_33240623_+SINEAluName=AluJb
ADediting_956348chr21_33240624_+SINEAluName=AluJb
ADediting_956349chr21_33240626_+SINEAluName=AluJb
ADediting_956350chr21_33240628_+SINEAluName=AluJb
ADediting_956351chr21_33240639_+SINEAluName=AluJb
ADediting_956352chr21_33240668_+SINEAluName=AluJb
ADediting_956353chr21_33240680_+SINEAluName=AluJb
ADediting_956354chr21_33240683_+SINEAluName=AluJb
ADediting_956355chr21_33240685_+SINEAluName=AluJb
ADediting_956356chr21_33240695_+SINEAluName=AluJb
ADediting_956357chr21_33240705_+SINEAluName=AluJb
ADediting_956358chr21_33240709_+SINEAluName=AluJb
ADediting_956359chr21_33240717_+SINEAluName=AluJb
ADediting_956360chr21_33240735_+SINEAluName=AluJb
ADediting_956361chr21_33240772_+SINEAluName=AluJb
ADediting_956362chr21_33242477_+SINEAluName=AluY
ADediting_956363chr21_33242478_+SINEAluName=AluY
ADediting_956364chr21_33242504_+SINEAluName=AluY
ADediting_956365chr21_33242521_+SINEAluName=AluY
ADediting_956366chr21_33242545_+SINEAluName=AluY
ADediting_956367chr21_33242576_+SINEAluName=AluY
ADediting_956368chr21_33242579_+SINEAluName=AluY
ADediting_956369chr21_33242583_+SINEAluName=AluY
ADediting_956370chr21_33242586_+SINEAluName=AluY
ADediting_956371chr21_33242612_+SINEAluName=AluY
ADediting_956372chr21_33242618_+SINEAluName=AluY
ADediting_956373chr21_33242653_+SINEAluName=AluY
ADediting_956374chr21_33242654_+SINEAluName=AluY
ADediting_956375chr21_33242713_+SINEAluName=AluY
ADediting_956376chr21_33242716_+SINEAluName=AluY
ADediting_956377chr21_33242809_+SINEAluName=AluSx1
ADediting_956378chr21_33242821_+SINEAluName=AluSx1
ADediting_956379chr21_33242858_+SINEAluName=AluSx1
ADediting_956380chr21_33242868_+SINEAluName=AluSx1
ADediting_956381chr21_33242888_+SINEAluName=AluSx1
ADediting_956382chr21_33242889_+SINEAluName=AluSx1
ADediting_956383chr21_33242893_+SINEAluName=AluSx1
ADediting_956384chr21_33242915_+SINEAluName=AluSx1
ADediting_956385chr21_33242918_+SINEAluName=AluSx1
ADediting_956386chr21_33242928_+SINEAluName=AluSx1
ADediting_956387chr21_33242930_+SINEAluName=AluSx1
ADediting_956388chr21_33242969_+SINEAluName=AluSx1
ADediting_956389chr21_33242972_+SINEAluName=AluSx1
ADediting_956390chr21_33242978_+SINEAluName=AluSx1
ADediting_956391chr21_33242979_+SINEAluName=AluSx1
ADediting_956392chr21_33243048_+SINEAluName=AluSx1
ADediting_956393chr21_33243051_+SINEAluName=AluSx1
ADediting_956394chr21_33243062_+SINEAluName=AluSx1
ADediting_956395chr21_33243107_+SINEAluName=AluSx3
ADediting_956396chr21_33243123_+SINEAluName=AluSx3
ADediting_956397chr21_33243135_+SINEAluName=AluSx3
ADediting_956398chr21_33243152_+SINEAluName=AluSx3
ADediting_956399chr21_33243200_+SINEAluName=AluSx3
ADediting_956400chr21_33243209_+SINEAluName=AluSx3
ADediting_956401chr21_33243212_+SINEAluName=AluSx3
ADediting_956402chr21_33243232_+SINEAluName=AluSx3
ADediting_956403chr21_33243235_+SINEAluName=AluSx3
ADediting_956404chr21_33243240_+SINEAluName=AluSx3
ADediting_956405chr21_33243244_+SINEAluName=AluSx3
ADediting_956406chr21_33243258_+SINEAluName=AluSx3
ADediting_956407chr21_33243264_+SINEAluName=AluSx3
ADediting_956408chr21_33243267_+SINEAluName=AluSx3
ADediting_956409chr21_33243273_+SINEAluName=AluSx3
ADediting_956410chr21_33243312_+SINEAluName=AluSx3
ADediting_956411chr21_33243330_+SINEAluName=AluSx3
ADediting_956412chr21_33243345_+SINEAluName=AluSx3
ADediting_956413chr21_33243357_+SINEAluName=AluSx3
ADediting_956414chr21_33249086_+SINEAluName=AluSx1
ADediting_956415chr21_33249088_+SINEAluName=AluSx1
ADediting_956416chr21_33249089_+SINEAluName=AluSx1
ADediting_956417chr21_33249173_+SINEAluName=AluSx1
ADediting_956418chr21_33249213_+SINEAluName=AluSx1
ADediting_956419chr21_33249223_+SINEAluName=AluSx1
ADediting_956420chr21_33249264_+SINEAluName=AluSx1
ADediting_956421chr21_33249265_+SINEAluName=AluSx1
ADediting_956422chr21_33249269_+SINEAluName=AluSx1
ADediting_956423chr21_33249276_+SINEAluName=AluSx1
ADediting_956424chr21_33250556_+SINEAluName=AluSq2
ADediting_956425chr21_33250618_+SINEAluName=AluSq2
ADediting_956426chr21_33250664_+SINEAluName=AluSq2
ADediting_956427chr21_33250667_+SINEAluName=AluSq2
ADediting_956428chr21_33250677_+SINEAluName=AluSq2
ADediting_956429chr21_33250728_+SINEAluName=AluSq2
ADediting_956430chr21_33250773_+SINEAluName=AluSq2
ADediting_956431chr21_33250782_+SINEAluName=AluSq2
ADediting_956432chr21_33250791_+SINEAluName=AluSq2
ADediting_956433chr21_33250813_+SINEAluName=AluSq2
ADediting_956434chr21_33250816_+SINEAluName=AluSq2
ADediting_956435chr21_33250819_+SINEAluName=AluSq2
ADediting_956436chr21_33251828_+SINEAluName=AluSx1
ADediting_956437chr21_33251844_+SINEAluName=AluSx1
ADediting_956438chr21_33251849_+SINEAluName=AluSx1
ADediting_956439chr21_33251850_+SINEAluName=AluSx1
ADediting_956440chr21_33251854_+SINEAluName=AluSx1
ADediting_956441chr21_33251858_+SINEAluName=AluSx1
ADediting_956442chr21_33251912_+SINEAluName=AluSx1
ADediting_956443chr21_33251990_+SINEAluName=AluSx1
ADediting_956444chr21_33252008_+SINEAluName=AluSx1
ADediting_956445chr21_33261068_+SINEAluName=AluSz6
ADediting_956446chr21_33261090_+SINEAluName=AluSz6
ADediting_956447chr21_33261106_+SINEAluName=AluSz6
ADediting_956448chr21_33261111_+SINEAluName=AluSz6
ADediting_956449chr21_33261117_+SINEAluName=AluSz6
ADediting_956450chr21_33261130_+SINEAluName=AluSz6
ADediting_956451chr21_33261162_+SINEAluName=AluSz6
ADediting_956452chr21_33261166_+SINEAluName=AluSz6
ADediting_956453chr21_33261178_+SINEAluName=AluSz6
ADediting_956454chr21_33261237_+SINEAluName=AluSz6
ADediting_956455chr21_33261246_+SINEAluName=AluSz6
ADediting_956456chr21_33261299_+SINEAluName=AluSz6
ADediting_956457chr21_33261597_+SINEAluName=AluJb
ADediting_956458chr21_33261676_+SINEAluName=AluJb
ADediting_956459chr21_33261694_+SINEAluName=AluJb
ADediting_956460chr21_33261769_+SINEAluName=AluJb
ADediting_956461chr21_33261817_+SINEAluName=AluJb
ADediting_956462chr21_33261841_+SINEAluName=AluJb
ADediting_956463chr21_33261871_+SINEAluName=AluJb
ADediting_956464chr21_33262090_+SINEAluName=AluSg7
ADediting_956465chr21_33262109_+SINEAluName=AluSg7
ADediting_956466chr21_33262112_+SINEAluName=AluSg7
ADediting_956467chr21_33262142_+SINEAluName=AluSg7
ADediting_956468chr21_33262209_+SINEAluName=AluSg7
ADediting_956469chr21_33262228_+SINEAluName=AluSg7
ADediting_956470chr21_33262305_+SINEAluName=AluSg7
ADediting_956471chr21_33262314_+SINEAluName=AluSg7
ADediting_956472chr21_33262566_+SINEAluName=AluJr
ADediting_956473chr21_33262586_+SINEAluName=AluJr
ADediting_956474chr21_33262623_+SINEAluName=AluJr
ADediting_956475chr21_33262631_+SINEAluName=AluJr
ADediting_956476chr21_33262647_+SINEAluName=AluJr
ADediting_956477chr21_33262663_+SINEAluName=AluJr
ADediting_956478chr21_33262688_+SINEAluName=AluJr
ADediting_1568806chr21_33243248_+SINEAluName=AluSx3
ADediting_1568807chr21_33262565_+SINEAluName=AluJr
ADediting_1641768chr21_33240587_+SINEAluName=AluJb

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RNA A-to-I editing events in the alternative splicing sites for IFNAR2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for IFNAR2

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
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Soverview

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for IFNAR2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
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The effects of the RNA editing to the miRNA binding sites for IFNAR2


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337758chr7_5495892_-ENSG00000159110.19ENST00000342101.7IFNAR2-201hsa-miR-589-5pchr2133263796332638027mer-m83326378433263803152-22.81
ADediting_1337758chr7_5495892_-ENSG00000159110.19ENST00000342136.8IFNAR2-202hsa-miR-589-5pchr2133263796332638027mer-m83326378433263803152-22.81
ADediting_1337758chr7_5495892_-ENSG00000159110.19ENST00000404220.7IFNAR2-205hsa-miR-589-5pchr2133263796332638027mer-m83326378433263803152-22.81
ADediting_496066chr15_66496985_-ENSG00000159110.19ENST00000404220.7IFNAR2-205hsa-miR-4512chr2133265330332653367mer-m83326531633265337143-13.73

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_107020chr1_37500952_-ENSG00000159110.19ENST00000342101.7IFNAR2-201hsa-miR-5581-3pchr2133262968332629747mer-m83326295433262975148-12.59
ADediting_107020chr1_37500952_-ENSG00000159110.19ENST00000404220.7IFNAR2-205hsa-miR-5581-3pchr2133262968332629747mer-m83326295433262975148-12.59
ADediting_527135chr16_24203190_+ENSG00000159110.19ENST00000342101.7IFNAR2-201hsa-miR-1273h-3pchr2133263580332635878mer-1a3326356633263587140-13.11
ADediting_527135chr16_24203190_+ENSG00000159110.19ENST00000342136.8IFNAR2-202hsa-miR-1273h-3pchr2133263580332635878mer-1a3326356633263587140-13.11
ADediting_527135chr16_24203190_+ENSG00000159110.19ENST00000404220.7IFNAR2-205hsa-miR-1273h-3pchr2133263580332635878mer-1a3326356633263587140-13.11
ADediting_843620chr2_207754818_+ENSG00000159110.19ENST00000404220.7IFNAR2-205hsa-miR-4775chr2133264828332648347mer-m83326482133264844153-6.98
ADediting_843620chr2_207754818_+ENSG00000159110.19ENST00000404220.7IFNAR2-205hsa-miR-4775chr2133264837332648448mer-1a3326482133264844153-6.98

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for IFNAR2

check button - RNA A-to-I editing in mRNA.
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ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000382264.7protein_codingSoverviewSoverview
ENST00000404220.7protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_1568807ENST00000382264.7chr21_33262565_+1198-444.50-441.40-455.90
ADediting_956472ENST00000382264.7chr21_33262566_+1199-441.40-441.40-455.90
ADediting_956473ENST00000382264.7chr21_33262586_+1219-445.70-441.40-455.90
ADediting_956474ENST00000382264.7chr21_33262623_+1256-443.70-441.40-455.90
ADediting_956475ENST00000382264.7chr21_33262631_+1264-442.20-441.40-455.90
ADediting_956476ENST00000382264.7chr21_33262647_+1280-444.90-441.40-455.90
ADediting_956477ENST00000382264.7chr21_33262663_+1296-442.80-441.40-455.90
ADediting_956478ENST00000382264.7chr21_33262688_+1321-444.90-441.40-455.90
ADediting_1568807ENST00000404220.7chr21_33262565_+1174-1549.90-1549.10-1561.80
ADediting_956472ENST00000404220.7chr21_33262566_+1175-1549.10-1549.10-1561.80
ADediting_956473ENST00000404220.7chr21_33262586_+1195-1549.70-1549.10-1561.80
ADediting_956474ENST00000404220.7chr21_33262623_+1232-1549.10-1549.10-1561.80
ADediting_956475ENST00000404220.7chr21_33262631_+1240-1550.10-1549.10-1561.80
ADediting_956476ENST00000404220.7chr21_33262647_+1256-1549.10-1549.10-1561.80
ADediting_956477ENST00000404220.7chr21_33262663_+1272-1548.70-1549.10-1561.80
ADediting_956478ENST00000404220.7chr21_33262688_+1297-1552.20-1549.10-1561.80

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for IFNAR2

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC6.41605459197872e-300.5855354596963495.30905004218204e-230.5213247260515050.000117957544653330.216950443504343
AC2.9095823285193e-700.8477880296977811.91836326368327e-370.6953281217770241.23962784242842e-250.597987794716504
PCC7.34139766674728e-110.4489216960627194.31515373839642e-090.4088269598950895.04134989176817e-060.32337927339692
CER1.11344044829297e-310.7780128169526038.27403082898717e-130.5415993635362350.005220015179824050.226972854388321
TCX2.87694105182016e-120.5305840456300470.2889196128095960.08715322301355253.04124883596089e-100.485475888831663
FP2.39096354017883e-220.6453496588505959.30967410524422e-160.5548061753824610.004541517381176170.211781498514646
PG9.66998738829311e-370.7632141855253668.32514614630079e-200.6030895842654770.541223172489280.0450791912457692
STG8.99668685524499e-090.5773073296179168.15075851183145e-070.5079157918265670.008378144296529530.285911629617433

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Relation with AD stages for IFNAR2

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
TCX2.86821599139451e-060.436705779066344

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RelatedDrugs for IFNAR2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
IFNAR2P48551DB00022Peginterferon alfa-2bInterferon alpha/beta receptor 2biotechapproved
IFNAR2P48551DB00068Interferon beta-1bInterferon alpha/beta receptor 2biotechapproved
IFNAR2P48551DB00105Interferon alfa-2bInterferon alpha/beta receptor 2biotechapproved
IFNAR2P48551DB06152NylidrinInterferon alpha/beta receptor 2small moleculeapproved
IFNAR2P48551DB00008Peginterferon alfa-2aInterferon alpha/beta receptor 2biotechapproved|investigational
IFNAR2P48551DB00011Interferon alfa-n1Interferon alpha/beta receptor 2biotechapproved|investigational
IFNAR2P48551DB00034Interferon Alfa-2a, RecombinantInterferon alpha/beta receptor 2biotechapproved|investigational
IFNAR2P48551DB00060Interferon beta-1aInterferon alpha/beta receptor 2biotechapproved|investigational
IFNAR2P48551DB00069Interferon alfacon-1Interferon alpha/beta receptor 2biotechapproved|investigational

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RelatedDiseases for IFNAR2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource