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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for IFI16 |
 Gene summary |
| Gene information | Gene symbol | IFI16 | Gene ID | 3428 |
| Gene name | interferon gamma inducible protein 16 | |
| Synonyms | IFNGIP1|PYHIN2 | |
| Cytomap | 1q23.1 | |
| Type of gene | protein-coding | |
| Description | gamma-interferon-inducible protein 16IFI16 beta isoforminterferon-gamma induced protein IFI 16interferon-inducible myeloid differentiation transcriptional activator | |
| Modification date | 20200313 | |
| UniProtAcc | Q16666, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| IFI16 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12894224|24413532 |
| IFI16 | GO:0002218 | activation of innate immune response | 21575908 |
| IFI16 | GO:0030224 | monocyte differentiation | 9766636 |
| IFI16 | GO:0032731 | positive regulation of interleukin-1 beta production | 21575908 |
| IFI16 | GO:0042149 | cellular response to glucose starvation | 21573174 |
| IFI16 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 14654789 |
| IFI16 | GO:0043392 | negative regulation of DNA binding | 22291595 |
| IFI16 | GO:0045071 | negative regulation of viral genome replication | 22291595 |
| IFI16 | GO:0045824 | negative regulation of innate immune response | 22046441 |
| IFI16 | GO:0045892 | negative regulation of transcription, DNA-templated | 9642285 |
| IFI16 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11146555 |
| IFI16 | GO:0051607 | defense response to virus | 21478870 |
| IFI16 | GO:0071479 | cellular response to ionizing radiation | 14654789 |
| IFI16 | GO:2000117 | negative regulation of cysteine-type endopeptidase activity | 22046441 |
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RNA A-to-I events for IFI16 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_36456(159050574, +), ADediting_36457(159050629, +), ADediting_36458(159050630, +), ADediting_36459(159050659, +), ADediting_36460(159050676, +), ADediting_36461(159050679, +), ADediting_36462(159050688, +), ADediting_36463(159050689, +), ADediting_36464(159050693, +), ADediting_36465(159050694, +), ADediting_36466(159050695, +), ADediting_36467(159050706, +), ADediting_36468(159050709, +), ADediting_36469(159050713, +), ADediting_36470(159050716, +), ADediting_36471(159050717, +), ADediting_36472(159050719, +), ADediting_36473(159050748, +), ADediting_36474(159050749, +), ADediting_36475(159050753, +), ADediting_36476(159050754, +), ADediting_36477(159050755, +), ADediting_36478(159050961, +), ADediting_36479(159051087, +), ADediting_36480(159051105, +), ADediting_36481(159051106, +), ADediting_36482(159051121, +), ADediting_36483(159051131, +), ADediting_36484(159051134, +), ADediting_36485(159051147, +), ADediting_36486(159051152, +), ADediting_36487(159051167, +), ADediting_36488(159051185, +), ADediting_36489(159051191, +), ADediting_36490(159051203, +), ADediting_36491(159051206, +), ADediting_36492(159051213, +), ADediting_36493(159051214, +), ADediting_36494(159051224, +), ADediting_36495(159051231, +), ADediting_36496(159051234, +), ADediting_36497(159051244, +), ADediting_36498(159051249, +), |
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RNA editing positional annotations for IFI16 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_36456 | chr1_159050574_+ | intronic |
| ADediting_36457 | chr1_159050629_+ | intronic |
| ADediting_36458 | chr1_159050630_+ | intronic |
| ADediting_36459 | chr1_159050659_+ | intronic |
| ADediting_36460 | chr1_159050676_+ | intronic |
| ADediting_36461 | chr1_159050679_+ | intronic |
| ADediting_36462 | chr1_159050688_+ | intronic |
| ADediting_36463 | chr1_159050689_+ | intronic |
| ADediting_36464 | chr1_159050693_+ | intronic |
| ADediting_36465 | chr1_159050694_+ | intronic |
| ADediting_36466 | chr1_159050695_+ | intronic |
| ADediting_36467 | chr1_159050706_+ | intronic |
| ADediting_36468 | chr1_159050709_+ | intronic |
| ADediting_36469 | chr1_159050713_+ | intronic |
| ADediting_36470 | chr1_159050716_+ | intronic |
| ADediting_36471 | chr1_159050717_+ | intronic |
| ADediting_36472 | chr1_159050719_+ | intronic |
| ADediting_36473 | chr1_159050748_+ | intronic |
| ADediting_36474 | chr1_159050749_+ | intronic |
| ADediting_36475 | chr1_159050753_+ | intronic |
| ADediting_36476 | chr1_159050754_+ | intronic |
| ADediting_36477 | chr1_159050755_+ | intronic |
| ADediting_36478 | chr1_159050961_+ | intronic |
| ADediting_36479 | chr1_159051087_+ | intronic |
| ADediting_36480 | chr1_159051105_+ | intronic |
| ADediting_36481 | chr1_159051106_+ | intronic |
| ADediting_36482 | chr1_159051121_+ | intronic |
| ADediting_36483 | chr1_159051131_+ | intronic |
| ADediting_36484 | chr1_159051134_+ | intronic |
| ADediting_36485 | chr1_159051147_+ | intronic |
| ADediting_36486 | chr1_159051152_+ | intronic |
| ADediting_36487 | chr1_159051167_+ | intronic |
| ADediting_36488 | chr1_159051185_+ | intronic |
| ADediting_36489 | chr1_159051191_+ | intronic |
| ADediting_36490 | chr1_159051203_+ | intronic |
| ADediting_36491 | chr1_159051206_+ | intronic |
| ADediting_36492 | chr1_159051213_+ | intronic |
| ADediting_36493 | chr1_159051214_+ | intronic |
| ADediting_36494 | chr1_159051224_+ | intronic |
| ADediting_36495 | chr1_159051231_+ | intronic |
| ADediting_36496 | chr1_159051234_+ | intronic |
| ADediting_36497 | chr1_159051244_+ | intronic |
| ADediting_36498 | chr1_159051249_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
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RNA A-to-I editing events in the alternative splicing sites for IFI16 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for IFI16 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for IFI16 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for IFI16 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for IFI16 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for IFI16 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_36457 | chr1_159050629_+ | 0.00286494962551893 | 0.168823504702006 | 0.50849236710596 | 0.0376918200357417 | 2.57501933552438e-11 | 0.366962143620638 |
| DLPFC | ADediting_36458 | chr1_159050630_+ | 0.00263831831888813 | 0.170226137500467 | 0.494662528719709 | 0.0389293477453473 | 1.05816661878127e-12 | 0.389988478808695 |
| DLPFC | ADediting_36459 | chr1_159050659_+ | 0.00385289437264562 | 0.16369149915193 | 0.8300618316124 | 0.012238710539658 | 1.96706114023026e-17 | 0.457388142955279 |
| DLPFC | ADediting_36465 | chr1_159050694_+ | 0.00755315723684419 | 0.151461895143963 | 0.606225937203107 | 0.0293890219348059 | 1.18511239362935e-11 | 0.372729558337492 |
| DLPFC | ADediting_36466 | chr1_159050695_+ | 0.00479578515974107 | 0.159805074470772 | 0.656215490495617 | 0.0253809556559904 | 1.05159086394757e-13 | 0.405590382894026 |
| DLPFC | ADediting_36470 | chr1_159050716_+ | 0.0010837925357562 | 0.184745865296427 | 0.139229561936053 | 0.0841735282787608 | 1.23714090042337e-10 | 0.35493305334819 |
| DLPFC | ADediting_36472 | chr1_159050719_+ | 0.000982691706348425 | 0.186279818086381 | 0.154392438249747 | 0.0810826828768 | 2.01863626856773e-08 | 0.311923976824188 |
| DLPFC | ADediting_36479 | chr1_159051087_+ | 0.0710674656224855 | 0.102663423876534 | 0.727963727613973 | 0.0198339094688514 | 8.65557030243594e-09 | 0.319552535512077 |
| DLPFC | ADediting_36480 | chr1_159051105_+ | 0.085850539577232 | 0.0977202037289436 | 0.900219742283106 | -0.00715011288797582 | 6.97340958131001e-08 | 0.300350702415568 |
| DLPFC | ADediting_36484 | chr1_159051134_+ | 0.0136424523535036 | 0.139965377901369 | 0.736787166286748 | 0.0191654921809332 | 2.25403539391542e-10 | 0.350198422101757 |
| DLPFC | ADediting_36485 | chr1_159051147_+ | 0.00652974084816259 | 0.154179259937276 | 0.832241833175927 | 0.0120793361947445 | 4.39674605391511e-13 | 0.396020280412245 |
| DLPFC | ADediting_36488 | chr1_159051185_+ | 0.0222219045730404 | 0.129841814977411 | 0.664313214782652 | -0.0247437906669182 | 2.08166193000135e-17 | 0.457073857674074 |
| DLPFC | ADediting_36490 | chr1_159051203_+ | 0.0110798961342416 | 0.144100288390723 | 0.948565654877067 | 0.00367866260362438 | 2.02236905921311e-21 | 0.50449672020011 |
| DLPFC | ADediting_36491 | chr1_159051206_+ | 0.00761532728253423 | 0.151307644068492 | 0.987646068811658 | 0.000882997630907394 | 1.20742725549672e-18 | 0.472488819666458 |
| DLPFC | ADediting_36492 | chr1_159051213_+ | 0.00023259565626554 | 0.20760618875568 | 0.785263219637993 | 0.0155368978223996 | 4.60441774024191e-24 | 0.532124483917272 |
| DLPFC | ADediting_36493 | chr1_159051214_+ | 0.0130687043958155 | 0.140827696385563 | 0.986562545043315 | -0.000960449520706312 | 6.06141867001208e-17 | 0.451080332433326 |
| DLPFC | ADediting_36494 | chr1_159051224_+ | 0.00673222390984167 | 0.153612784612794 | 0.772538294145567 | 0.0164827656408237 | 1.61892316086862e-14 | 0.417662447849376 |
| DLPFC | ADediting_36497 | chr1_159051244_+ | 0.0472202977452601 | 0.112797495968908 | 0.824176302723692 | -0.0126694658007893 | 1.20478669030162e-14 | 0.419525083080734 |
| DLPFC | ADediting_36498 | chr1_159051249_+ | 0.0188385130981171 | 0.13334028707015 | 0.964176149260639 | -0.00256126572842432 | 1.02799062255131e-13 | 0.40573977924528 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| AC | 9.04549050424563e-50 | 0.767354083262974 | 3.36148964046694e-25 | 0.593664442788945 | 4.98987029353089e-14 | 0.452597980146192 |
| CER | 0.0213275567131947 | 0.187863287908637 | 0.165475375409016 | 0.113822886477842 | 1.82742809256636e-05 | 0.342113873424989 |
| TCX | 0.0010534627807109 | 0.264893085112198 | 0.00221049040621195 | -0.248037881681539 | 8.47325618074037e-12 | 0.520703068397598 |
| FP | 1.85116495183648e-05 | 0.314970337839216 | 0.963974528968342 | -0.00340938890583203 | 0.00488154528993668 | 0.210094573661572 |
| PG | 4.1449929164158e-26 | 0.675220521810294 | 9.4142340297602e-13 | 0.492423750471662 | 0.0371484240212821 | 0.152946548518833 |
| STG | 0.0548391136722237 | 0.210307097522983 | 0.217128957258585 | -0.136073639649392 | 0.00140847410268104 | 0.342887101591421 |
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Relation with AD stages for IFI16 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 9.0545535136825e-05 | 0.367680013432537 |
| TCX | 1.95093059459809e-07 | 0.479790260764966 |
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RelatedDrugs for IFI16 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IFI16 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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