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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for IDH2

check button Gene summary
Gene informationGene symbol

IDH2

Gene ID

3418

Gene nameisocitrate dehydrogenase (NADP(+)) 2
SynonymsD2HGA2|ICD-M|IDH|IDHM|IDP|IDPM|mNADP-IDH
Cytomap

15q26.1

Type of geneprotein-coding
Descriptionisocitrate dehydrogenase [NADP], mitochondrialNADP(+)-specific ICDHisocitrate dehydrogenase (NADP(+)) 2, mitochondrialisocitrate dehydrogenase 2 (NADP+), mitochondrialoxalosuccinate decarboxylase
Modification date20200313
UniProtAcc

P48735,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for IDH2

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_509246(90083162, -), ADediting_509247(90083163, -), ADediting_509248(90083168, -), ADediting_509249(90083170, -), ADediting_509250(90083190, -), ADediting_509251(90083193, -), ADediting_509252(90083200, -), ADediting_509253(90083205, -), ADediting_509254(90083209, -), ADediting_509255(90083218, -), ADediting_509256(90083229, -), ADediting_509257(90083230, -), ADediting_509258(90083238, -), ADediting_509259(90083239, -), ADediting_509260(90083240, -), ADediting_509261(90083241, -), ADediting_509262(90083244, -), ADediting_509263(90083261, -), ADediting_509264(90083265, -), ADediting_509265(90083271, -), ADediting_509266(90083277, -), ADediting_509267(90083293, -), ADediting_509268(90083297, -), ADediting_509269(90083301, -), ADediting_509270(90083303, -), ADediting_509271(90083306, -), ADediting_509272(90083308, -), ADediting_509273(90083309, -), ADediting_509274(90083310, -), ADediting_509275(90083315, -), ADediting_509276(90083321, -), ADediting_509277(90083326, -), ADediting_509278(90083328, -), ADediting_509279(90083334, -), ADediting_509280(90083336, -), ADediting_509281(90083337, -), ADediting_509282(90083346, -), ADediting_509283(90083349, -), ADediting_509284(90083351, -), ADediting_509285(90083360, -), ADediting_509286(90083365, -), ADediting_509287(90083370, -), ADediting_509288(90083405, -), ADediting_509289(90083406, -), ADediting_509290(90083408, -), ADediting_509291(90083422, -), ADediting_509292(90083424, -), ADediting_509293(90092409, -), ADediting_509294(90092478, -), ADediting_509295(90092494, -), ADediting_509296(90092498, -), ADediting_509297(90092516, -), ADediting_509298(90092544, -), ADediting_509299(90092639, -), ADediting_509300(90092653, -), ADediting_509301(90092679, -), ADediting_509302(90092714, -), ADediting_509303(90092715, -), ADediting_509304(90092751, -), ADediting_509305(90092781, -), ADediting_509306(90092782, -), ADediting_509307(90092824, -), ADediting_509308(90092860, -), ADediting_509309(90092878, -), ADediting_509310(90093682, -), ADediting_509311(90093705, -), ADediting_509312(90093716, -), ADediting_509313(90093725, -), ADediting_509314(90093735, -), ADediting_509315(90093757, -), ADediting_509316(90093758, -), ADediting_509317(90093784, -), ADediting_509318(90093813, -), ADediting_509319(90093815, -), ADediting_509320(90093816, -), ADediting_509321(90093823, -), ADediting_509322(90093824, -), ADediting_509323(90093847, -), ADediting_509324(90093852, -), ADediting_509325(90093871, -), ADediting_509326(90093884, -), ADediting_509327(90093901, -), ADediting_509328(90094655, -), ADediting_509329(90094694, -), ADediting_509330(90094726, -), ADediting_509331(90094740, -), ADediting_509332(90094790, -), ADediting_509333(90094833, -), ADediting_509334(90094839, -), ADediting_509335(90096052, -), ADediting_509336(90096062, -), ADediting_509337(90096117, -), ADediting_509338(90096151, -), ADediting_509339(90096178, -), ADediting_509340(90096253, -), ADediting_509341(90096256, -), ADediting_509342(90096680, -), ADediting_509343(90096725, -), ADediting_509344(90096733, -), ADediting_509345(90096747, -), ADediting_509346(90096750, -), ADediting_509347(90096802, -), ADediting_509348(90096851, -), ADediting_509349(90096857, -), ADediting_509350(90096862, -), ADediting_509351(90097417, -), ADediting_509352(90097895, -), ADediting_509353(90097928, -), ADediting_509354(90098947, -), ADediting_509355(90098965, -), ADediting_509356(90099731, -), ADediting_1540725(90092673, -), ADediting_1540726(90092682, -), ADediting_1540727(90093289, -), ADediting_1540728(90093302, -), ADediting_1540729(90096658, -), ADediting_1540730(90098790, -), ADediting_1540731(90098976, -), ADediting_1540732(90098981, -), ADediting_1540733(90098983, -), ADediting_1540734(90098984, -), ADediting_1540735(90098988, -), ADediting_1540736(90099753, -), ADediting_1623543(90083357, -),

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RNA editing positional annotations for IDH2 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_509246chr15_90083162_-UTR3
ADediting_509247chr15_90083163_-UTR3
ADediting_509248chr15_90083168_-UTR3
ADediting_509249chr15_90083170_-UTR3
ADediting_509250chr15_90083190_-UTR3
ADediting_509251chr15_90083193_-UTR3
ADediting_509252chr15_90083200_-UTR3
ADediting_509253chr15_90083205_-UTR3
ADediting_509254chr15_90083209_-UTR3
ADediting_509255chr15_90083218_-UTR3
ADediting_509256chr15_90083229_-UTR3
ADediting_509257chr15_90083230_-UTR3
ADediting_509258chr15_90083238_-UTR3
ADediting_509259chr15_90083239_-UTR3
ADediting_509260chr15_90083240_-UTR3
ADediting_509261chr15_90083241_-UTR3
ADediting_509262chr15_90083244_-UTR3
ADediting_509263chr15_90083261_-UTR3
ADediting_509264chr15_90083265_-UTR3
ADediting_509265chr15_90083271_-UTR3
ADediting_509266chr15_90083277_-UTR3
ADediting_509267chr15_90083293_-UTR3
ADediting_509268chr15_90083297_-UTR3
ADediting_509269chr15_90083301_-UTR3
ADediting_509270chr15_90083303_-UTR3
ADediting_509271chr15_90083306_-UTR3
ADediting_509272chr15_90083308_-UTR3
ADediting_509273chr15_90083309_-UTR3
ADediting_509274chr15_90083310_-UTR3
ADediting_509275chr15_90083315_-UTR3
ADediting_509276chr15_90083321_-UTR3
ADediting_509277chr15_90083326_-UTR3
ADediting_509278chr15_90083328_-UTR3
ADediting_509279chr15_90083334_-UTR3
ADediting_509280chr15_90083336_-UTR3
ADediting_509281chr15_90083337_-UTR3
ADediting_509282chr15_90083346_-UTR3
ADediting_509283chr15_90083349_-UTR3
ADediting_509284chr15_90083351_-UTR3
ADediting_509285chr15_90083360_-UTR3
ADediting_509286chr15_90083365_-UTR3
ADediting_509287chr15_90083370_-UTR3
ADediting_509288chr15_90083405_-UTR3
ADediting_509289chr15_90083406_-UTR3
ADediting_509290chr15_90083408_-UTR3
ADediting_509291chr15_90083422_-UTR3
ADediting_509292chr15_90083424_-UTR3
ADediting_509293chr15_90092409_-intronic
ADediting_509294chr15_90092478_-intronic
ADediting_509295chr15_90092494_-intronic
ADediting_509296chr15_90092498_-intronic
ADediting_509297chr15_90092516_-intronic
ADediting_509298chr15_90092544_-intronic
ADediting_509299chr15_90092639_-intronic
ADediting_509300chr15_90092653_-intronic
ADediting_509301chr15_90092679_-intronic
ADediting_509302chr15_90092714_-intronic
ADediting_509303chr15_90092715_-intronic
ADediting_509304chr15_90092751_-intronic
ADediting_509305chr15_90092781_-intronic
ADediting_509306chr15_90092782_-intronic
ADediting_509307chr15_90092824_-intronic
ADediting_509308chr15_90092860_-intronic
ADediting_509309chr15_90092878_-intronic
ADediting_509310chr15_90093682_-intronic
ADediting_509311chr15_90093705_-intronic
ADediting_509312chr15_90093716_-intronic
ADediting_509313chr15_90093725_-intronic
ADediting_509314chr15_90093735_-intronic
ADediting_509315chr15_90093757_-intronic
ADediting_509316chr15_90093758_-intronic
ADediting_509317chr15_90093784_-intronic
ADediting_509318chr15_90093813_-intronic
ADediting_509319chr15_90093815_-intronic
ADediting_509320chr15_90093816_-intronic
ADediting_509321chr15_90093823_-intronic
ADediting_509322chr15_90093824_-intronic
ADediting_509323chr15_90093847_-intronic
ADediting_509324chr15_90093852_-intronic
ADediting_509325chr15_90093871_-intronic
ADediting_509326chr15_90093884_-intronic
ADediting_509327chr15_90093901_-intronic
ADediting_509328chr15_90094655_-intronic
ADediting_509329chr15_90094694_-intronic
ADediting_509330chr15_90094726_-intronic
ADediting_509331chr15_90094740_-intronic
ADediting_509332chr15_90094790_-intronic
ADediting_509333chr15_90094833_-intronic
ADediting_509334chr15_90094839_-intronic
ADediting_509335chr15_90096052_-intronic
ADediting_509336chr15_90096062_-intronic
ADediting_509337chr15_90096117_-intronic
ADediting_509338chr15_90096151_-intronic
ADediting_509339chr15_90096178_-intronic
ADediting_509340chr15_90096253_-intronic
ADediting_509341chr15_90096256_-intronic
ADediting_509342chr15_90096680_-intronic
ADediting_509343chr15_90096725_-intronic
ADediting_509344chr15_90096733_-intronic
ADediting_509345chr15_90096747_-intronic
ADediting_509346chr15_90096750_-intronic
ADediting_509347chr15_90096802_-intronic
ADediting_509348chr15_90096851_-intronic
ADediting_509349chr15_90096857_-intronic
ADediting_509350chr15_90096862_-intronic
ADediting_509351chr15_90097417_-intronic
ADediting_509352chr15_90097895_-intronic
ADediting_509353chr15_90097928_-intronic
ADediting_509354chr15_90098947_-intronic
ADediting_509355chr15_90098965_-intronic
ADediting_509356chr15_90099731_-intronic
ADediting_1540725chr15_90092673_-intronic
ADediting_1540726chr15_90092682_-intronic
ADediting_1540727chr15_90093289_-intronic
ADediting_1540728chr15_90093302_-intronic
ADediting_1540729chr15_90096658_-intronic
ADediting_1540730chr15_90098790_-intronic
ADediting_1540731chr15_90098976_-intronic
ADediting_1540732chr15_90098981_-intronic
ADediting_1540733chr15_90098983_-intronic
ADediting_1540734chr15_90098984_-intronic
ADediting_1540735chr15_90098988_-intronic
ADediting_1540736chr15_90099753_-intronic
ADediting_1623543chr15_90083357_-UTR3

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_509246chr15_90083162_-SINEAluName=AluSz
ADediting_509247chr15_90083163_-SINEAluName=AluSz
ADediting_509248chr15_90083168_-SINEAluName=AluSz
ADediting_509249chr15_90083170_-SINEAluName=AluSz
ADediting_509250chr15_90083190_-SINEAluName=AluSz
ADediting_509251chr15_90083193_-SINEAluName=AluSz
ADediting_509252chr15_90083200_-SINEAluName=AluSz
ADediting_509253chr15_90083205_-SINEAluName=AluSz
ADediting_509254chr15_90083209_-SINEAluName=AluSz
ADediting_509255chr15_90083218_-SINEAluName=AluSz
ADediting_509256chr15_90083229_-SINEAluName=AluSz
ADediting_509257chr15_90083230_-SINEAluName=AluSz
ADediting_509258chr15_90083238_-SINEAluName=AluSz
ADediting_509259chr15_90083239_-SINEAluName=AluSz
ADediting_509260chr15_90083240_-SINEAluName=AluSz
ADediting_509261chr15_90083241_-SINEAluName=AluSz
ADediting_509262chr15_90083244_-SINEAluName=AluSz
ADediting_509263chr15_90083261_-SINEAluName=AluSz
ADediting_509264chr15_90083265_-SINEAluName=AluSz
ADediting_509265chr15_90083271_-SINEAluName=AluSz
ADediting_509266chr15_90083277_-SINEAluName=AluSz
ADediting_509267chr15_90083293_-SINEAluName=AluSz
ADediting_509268chr15_90083297_-SINEAluName=AluSz
ADediting_509269chr15_90083301_-SINEAluName=AluSz
ADediting_509270chr15_90083303_-SINEAluName=AluSz
ADediting_509271chr15_90083306_-SINEAluName=AluSz
ADediting_509272chr15_90083308_-SINEAluName=AluSz
ADediting_509273chr15_90083309_-SINEAluName=AluSz
ADediting_509274chr15_90083310_-SINEAluName=AluSz
ADediting_509275chr15_90083315_-SINEAluName=AluSz
ADediting_509276chr15_90083321_-SINEAluName=AluSz
ADediting_509277chr15_90083326_-SINEAluName=AluSz
ADediting_509278chr15_90083328_-SINEAluName=AluSz
ADediting_509279chr15_90083334_-SINEAluName=AluSz
ADediting_509280chr15_90083336_-SINEAluName=AluSz
ADediting_509281chr15_90083337_-SINEAluName=AluSz
ADediting_509282chr15_90083346_-SINEAluName=AluSz
ADediting_509283chr15_90083349_-SINEAluName=AluSz
ADediting_509284chr15_90083351_-SINEAluName=AluSz
ADediting_509285chr15_90083360_-SINEAluName=AluSz
ADediting_509286chr15_90083365_-SINEAluName=AluSz
ADediting_509287chr15_90083370_-SINEAluName=AluSz
ADediting_509288chr15_90083405_-SINEAluName=AluSz
ADediting_509289chr15_90083406_-SINEAluName=AluSz
ADediting_509290chr15_90083408_-SINEAluName=AluSz
ADediting_509291chr15_90083422_-SINEAluName=AluSz
ADediting_509292chr15_90083424_-SINEAluName=AluSz
ADediting_509293chr15_90092409_-SINEAluName=AluJr
ADediting_509294chr15_90092478_-SINEAluName=AluJr
ADediting_509295chr15_90092494_-SINEAluName=AluJr
ADediting_509296chr15_90092498_-SINEAluName=AluJr
ADediting_509297chr15_90092516_-SINEAluName=AluJr
ADediting_509298chr15_90092544_-SINEAluName=AluJr
ADediting_509299chr15_90092639_-SINEAluName=AluSz
ADediting_509300chr15_90092653_-SINEAluName=AluSz
ADediting_509301chr15_90092679_-SINEAluName=AluSz
ADediting_509302chr15_90092714_-SINEAluName=AluSz
ADediting_509303chr15_90092715_-SINEAluName=AluSz
ADediting_509304chr15_90092751_-SINEAluName=AluSz
ADediting_509305chr15_90092781_-SINEAluName=AluSz
ADediting_509306chr15_90092782_-SINEAluName=AluSz
ADediting_509307chr15_90092824_-SINEAluName=AluSz
ADediting_509308chr15_90092860_-SINEAluName=AluSz
ADediting_509309chr15_90092878_-SINEAluName=AluJr
ADediting_509310chr15_90093682_-SINEAluName=AluSz6
ADediting_509311chr15_90093705_-SINEAluName=AluSz6
ADediting_509312chr15_90093716_-SINEAluName=AluSz6
ADediting_509313chr15_90093725_-SINEAluName=AluSz6
ADediting_509314chr15_90093735_-SINEAluName=AluSz6
ADediting_509315chr15_90093757_-SINEAluName=AluSz6
ADediting_509316chr15_90093758_-SINEAluName=AluSz6
ADediting_509317chr15_90093784_-SINEAluName=AluSz6
ADediting_509318chr15_90093813_-SINEAluName=AluSz6
ADediting_509319chr15_90093815_-SINEAluName=AluSz6
ADediting_509320chr15_90093816_-SINEAluName=AluSz6
ADediting_509321chr15_90093823_-SINEAluName=AluSz6
ADediting_509322chr15_90093824_-SINEAluName=AluSz6
ADediting_509323chr15_90093847_-SINEAluName=AluSz6
ADediting_509324chr15_90093852_-SINEAluName=AluSz6
ADediting_509325chr15_90093871_-SINEAluName=AluSz6
ADediting_509326chr15_90093884_-SINEAluName=AluSz6
ADediting_509327chr15_90093901_-SINEAluName=AluSz6
ADediting_509328chr15_90094655_-SINEAluName=AluSz
ADediting_509329chr15_90094694_-SINEAluName=AluSz
ADediting_509330chr15_90094726_-SINEAluName=AluSz
ADediting_509331chr15_90094740_-SINEAluName=AluSz
ADediting_509332chr15_90094790_-SINEAluName=AluSz
ADediting_509333chr15_90094833_-SINEAluName=AluSz
ADediting_509334chr15_90094839_-SINEAluName=AluSz
ADediting_509335chr15_90096052_-SINEAluName=AluSz
ADediting_509336chr15_90096062_-SINEAluName=AluSz
ADediting_509337chr15_90096117_-SINEAluName=AluSz
ADediting_509338chr15_90096151_-SINEAluName=AluSz
ADediting_509339chr15_90096178_-SINEAluName=AluSz
ADediting_509340chr15_90096253_-SINEAluName=AluSz
ADediting_509341chr15_90096256_-SINEAluName=AluSz
ADediting_509342chr15_90096680_-SINEAluName=AluY
ADediting_509343chr15_90096725_-SINEAluName=AluY
ADediting_509344chr15_90096733_-SINEAluName=AluY
ADediting_509345chr15_90096747_-SINEAluName=AluY
ADediting_509346chr15_90096750_-SINEAluName=AluY
ADediting_509347chr15_90096802_-SINEAluName=AluY
ADediting_509348chr15_90096851_-SINEAluName=AluY
ADediting_509349chr15_90096857_-SINEAluName=AluY
ADediting_509350chr15_90096862_-SINEAluName=AluY
ADediting_509351chr15_90097417_-DNATcMar-TiggerName=MER44A
ADediting_509352chr15_90097895_-DNAhAT-CharlieName=MER102a
ADediting_509353chr15_90097928_-DNAhAT-CharlieName=MER102a
ADediting_509356chr15_90099731_-SINEAluName=AluJr
ADediting_1540725chr15_90092673_-SINEAluName=AluSz
ADediting_1540726chr15_90092682_-SINEAluName=AluSz
ADediting_1540727chr15_90093289_-SINEAluName=FLAM_C
ADediting_1540728chr15_90093302_-SINEAluName=FLAM_C
ADediting_1540729chr15_90096658_-SINEAluName=AluY
ADediting_1540730chr15_90098790_-SINEAluName=AluSx1
ADediting_1540736chr15_90099753_-SINEAluName=AluJr
ADediting_1623543chr15_90083357_-SINEAluName=AluSz

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RNA A-to-I editing events in the alternative splicing sites for IDH2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for IDH2

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for IDH2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for IDH2

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1623543chr15_90083357_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-331-3pchr1590083356900833627mer-m89008335590083374146-21.93
ADediting_509246chr15_90083162_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6838-3pchr1590083158900831647mer-m89008315790083175168-24.31
ADediting_509249chr15_90083170_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4715-3pchr1590083168900831747mer-m89008316790083189154-20.01
ADediting_509249chr15_90083170_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4727-5pchr1590083166900831727mer-m89008316590083185143-18.72
ADediting_509249chr15_90083170_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6817-5pchr1590083166900831727mer-1a9008316690083187143-30.67
ADediting_509250chr15_90083190_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4746-3pchr1590083189900831957mer-m89008318890083208144-24.03
ADediting_509252chr15_90083200_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4449chr1590083197900832037mer-m89008319690083217146-21.91
ADediting_509253chr15_90083205_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-324-3pchr1590083205900832117mer-m89008320490083226149-24.32
ADediting_509253chr15_90083205_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6075chr1590083200900832078mer-1a9008320090083221150-25.48
ADediting_509255chr15_90083218_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-1281chr1590083218900832247mer-m89008321790083233141-17.01
ADediting_509256chr15_90083229_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3155achr1590083225900832317mer-m89008322490083245141-19.17
ADediting_509256chr15_90083229_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3155bchr1590083225900832317mer-m89008322490083242141-19.17
ADediting_509256chr15_90083229_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-484chr1590083225900832317mer-m89008322490083245153-23.35
ADediting_509257chr15_90083230_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-9900chr1590083225900832317mer-m89008322490083243147-16.39
ADediting_509258chr15_90083238_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3124-3pchr1590083238900832447mer-m89008323790083264150-25.8
ADediting_509259chr15_90083239_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-141-5pchr1590083237900832437mer-m89008323690083258150-18.98
ADediting_509260chr15_90083240_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-1976chr1590083239900832468mer-1a9008323990083259149-24.39
ADediting_509261chr15_90083241_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4446-5pchr1590083238900832447mer-m89008323790083258163-26.81
ADediting_509261chr15_90083241_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6752-3pchr1590083240900832478mer-1a9008324090083259157-28.46
ADediting_509263chr15_90083261_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-1207-3pchr1590083261900832677mer-m89008326090083278145-13.53
ADediting_509263chr15_90083261_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-646chr1590083259900832657mer-m89008325890083277152-23.07
ADediting_509265chr15_90083271_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6886-5pchr1590083270900832767mer-m89008326990083290155-19.82
ADediting_509268chr15_90083297_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3190-5pchr1590083292900832987mer-m89008329190083310143-16.24
ADediting_509268chr15_90083297_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-548schr1590083293900832997mer-m89008329290083315141-10.8
ADediting_509269chr15_90083301_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6844chr1590083300900833067mer-m89008329990083320155-7.49
ADediting_509270chr15_90083303_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4742-3pchr1590083302900833098mer-1a9008330290083324142-9.18
ADediting_509271chr15_90083306_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3680-3pchr1590083301900833088mer-1a9008330190083323140-16.89
ADediting_509273chr15_90083309_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-526b-5pchr1590083308900833147mer-m89008330790083332147-12.02
ADediting_509274chr15_90083310_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-630chr1590083304900833118mer-1a9008330490083324158-18.08
ADediting_509275chr15_90083315_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4468chr1590083311900833188mer-1a9008331190083326149-13.71
ADediting_509275chr15_90083315_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4756-3pchr1590083315900833217mer-m89008331490083333151-16.82
ADediting_509276chr15_90083321_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-483-5pchr1590083318900833247mer-m89008331790083338140-14.01
ADediting_509277chr15_90083326_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-412-3pchr1590083326900833327mer-m89008332590083347153-17.3
ADediting_509277chr15_90083326_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6754-3pchr1590083326900833327mer-m89008332590083345144-15.76
ADediting_509278chr15_90083328_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-23a-5pchr1590083323900833297mer-m89008332290083344144-21.43
ADediting_509278chr15_90083328_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-23b-5pchr1590083323900833297mer-m89008332290083342156-19.96
ADediting_509279chr15_90083334_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-1306-3pchr1590083334900833407mer-m89008333390083350152-23.71
ADediting_509280chr15_90083336_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3190-5pchr1590083336900833427mer-m89008333590083354154-19.64
ADediting_509283chr15_90083349_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3176chr1590083345900833517mer-m89008334490083362160-27.08
ADediting_509283chr15_90083349_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3922-3pchr1590083345900833517mer-m89008334490083365154-24.26
ADediting_509283chr15_90083349_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6878-3pchr1590083346900833527mer-m89008334590083367150-24.54
ADediting_509284chr15_90083351_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4281chr1590083346900833538mer-1a9008334690083363142-21.92
ADediting_509284chr15_90083351_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6716-3pchr1590083351900833577mer-m89008335090083369148-21.99
ADediting_509286chr15_90083365_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-5699-5pchr1590083362900833687mer-m89008336190083382140-14.89
ADediting_509286chr15_90083365_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-874-5pchr1590083360900833678mer-1a9008336090083382142-20.54
ADediting_509288chr15_90083405_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-625-3pchr1590083404900834107mer-m89008340390083424148-12.62
ADediting_509290chr15_90083408_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-10399-5pchr1590083404900834107mer-m89008340390083424148-10.55
ADediting_509290chr15_90083408_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6504-3pchr1590083404900834107mer-m89008340390083424144-14.12
ADediting_509290chr15_90083408_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-7151-3pchr1590083405900834128mer-1a9008340590083429144-18.62

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_509246chr15_90083162_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-431-5pchr1590083159900831657mer-m89008315890083176147-17.87
ADediting_509247chr15_90083163_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-431-5pchr1590083159900831657mer-m89008315890083176147-17.87
ADediting_509247chr15_90083163_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-5691chr1590083162900831698mer-1a9008316290083182147-19.02
ADediting_509247chr15_90083163_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6805-3pchr1590083162900831698mer-1a9008316290083184154-21.46
ADediting_509248chr15_90083168_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-5691chr1590083162900831698mer-1a9008316290083182147-19.02
ADediting_509248chr15_90083168_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6773-3pchr1590083166900831738mer-1a9008316690083187142-15.63
ADediting_509248chr15_90083168_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6805-3pchr1590083162900831698mer-1a9008316290083184154-21.46
ADediting_509249chr15_90083170_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6773-3pchr1590083166900831738mer-1a9008316690083187142-15.63
ADediting_509249chr15_90083170_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6879-3pchr1590083168900831758mer-1a9008316890083190142-19.91
ADediting_509252chr15_90083200_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4638-5pchr1590083198900832058mer-1a9008319890083217146-20.28
ADediting_509253chr15_90083205_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4284chr1590083202900832087mer-m89008320190083218151-15.7
ADediting_509255chr15_90083218_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6836-3pchr1590083218900832247mer-m89008321790083237147-20.03
ADediting_509256chr15_90083229_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-498-5pchr1590083229900832357mer-m89008322890083250150-15.74
ADediting_509257chr15_90083230_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-498-5pchr1590083229900832357mer-m89008322890083250150-15.74
ADediting_509260chr15_90083240_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3074-5pchr1590083239900832468mer-1a9008323990083255146-19.63
ADediting_509261chr15_90083241_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3074-5pchr1590083239900832468mer-1a9008323990083255146-19.63
ADediting_509262chr15_90083244_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3074-5pchr1590083239900832468mer-1a9008323990083255146-19.63
ADediting_509262chr15_90083244_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6747-3pchr1590083241900832488mer-1a9008324190083263149-23.68
ADediting_509265chr15_90083271_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-1205chr1590083270900832767mer-m89008326990083287148-16.6
ADediting_509265chr15_90083271_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-1288-3pchr1590083267900832737mer-m89008326690083286140-13.17
ADediting_509265chr15_90083271_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3199chr1590083265900832728mer-1a9008326590083287145-20.1
ADediting_509265chr15_90083271_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4418chr1590083269900832757mer-m89008326890083286147-16.3
ADediting_509265chr15_90083271_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-509-3-5pchr1590083269900832757mer-m89008326890083287154-19.88
ADediting_509265chr15_90083271_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-509-5pchr1590083269900832757mer-m89008326890083286144-18.08
ADediting_509266chr15_90083277_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3665chr1590083271900832788mer-1a9008327190083288151-22.78
ADediting_509266chr15_90083277_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-764chr1590083273900832797mer-m89008327290083292151-22.93
ADediting_509266chr15_90083277_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-933chr1590083276900832827mer-m89008327590083296147-22.53
ADediting_509267chr15_90083293_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4794chr1590083292900832987mer-m89008329190083312140-12.3
ADediting_509267chr15_90083293_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-664a-5pchr1590083292900832987mer-m89008329190083314141-13.99
ADediting_509268chr15_90083297_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4735-5pchr1590083296900833027mer-m89008329590083316140-4.59
ADediting_509268chr15_90083297_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4794chr1590083292900832987mer-m89008329190083312140-12.3
ADediting_509268chr15_90083297_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-664a-5pchr1590083292900832987mer-m89008329190083314141-13.99
ADediting_509269chr15_90083301_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4735-5pchr1590083296900833027mer-m89008329590083316140-4.59
ADediting_509275chr15_90083315_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6832-5pchr1590083314900833207mer-m89008331390083335142-15.43
ADediting_509275chr15_90083315_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6869-5pchr1590083310900833178mer-1a9008331090083331147-16.14
ADediting_509276chr15_90083321_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3170chr1590083321900833277mer-m89008332090083341140-13.8
ADediting_509276chr15_90083321_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6855-5pchr1590083321900833277mer-m89008332090083344145-17.8
ADediting_509276chr15_90083321_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6890-5pchr1590083320900833267mer-m89008331990083339142-13.42
ADediting_509277chr15_90083326_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-193b-5pchr1590083321900833288mer-1a9008332190083342142-15.74
ADediting_509277chr15_90083326_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3170chr1590083321900833277mer-m89008332090083341140-13.8
ADediting_509277chr15_90083326_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6855-5pchr1590083321900833277mer-m89008332090083344145-17.8
ADediting_509279chr15_90083334_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4716-5pchr1590083331900833377mer-m89008333090083351140-11.3
ADediting_509279chr15_90083334_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4781-3pchr1590083333900833397mer-m89008333290083350144-13.86
ADediting_509280chr15_90083336_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4716-5pchr1590083331900833377mer-m89008333090083351140-11.3
ADediting_509280chr15_90083336_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4781-3pchr1590083333900833397mer-m89008333290083350144-13.86
ADediting_509281chr15_90083337_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4435chr1590083336900833438mer-1a9008333690083356146-18.85
ADediting_509281chr15_90083337_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4781-3pchr1590083333900833397mer-m89008333290083350144-13.86
ADediting_509282chr15_90083346_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3663-5pchr1590083345900833517mer-m89008334490083363148-23.23
ADediting_509282chr15_90083346_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6131chr1590083344900833507mer-m89008334390083361140-18.33
ADediting_509282chr15_90083346_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6843-3pchr1590083346900833527mer-m89008334590083364152-19
ADediting_509282chr15_90083346_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6848-3pchr1590083346900833527mer-m89008334590083362142-14.3
ADediting_509283chr15_90083349_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3663-5pchr1590083345900833517mer-m89008334490083363148-23.23
ADediting_509283chr15_90083349_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6131chr1590083344900833507mer-m89008334390083361140-18.33
ADediting_509283chr15_90083349_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6843-3pchr1590083346900833527mer-m89008334590083364152-19
ADediting_509283chr15_90083349_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6848-3pchr1590083346900833527mer-m89008334590083362142-14.3
ADediting_509284chr15_90083351_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6843-3pchr1590083346900833527mer-m89008334590083364152-19
ADediting_509284chr15_90083351_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6848-3pchr1590083346900833527mer-m89008334590083362142-14.3
ADediting_509285chr15_90083360_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3176chr1590083359900833657mer-m89008335890083380147-21.78
ADediting_509285chr15_90083360_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-3922-3pchr1590083359900833657mer-m89008335890083378153-18.19
ADediting_509285chr15_90083360_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6878-3pchr1590083360900833667mer-m89008335990083381142-23.66
ADediting_509286chr15_90083365_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6878-3pchr1590083360900833667mer-m89008335990083381142-23.66
ADediting_509287chr15_90083370_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-1245achr1590083368900833747mer-m89008336790083387153-19.08
ADediting_509287chr15_90083370_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-8079chr1590083368900833747mer-m89008336790083386149-13.16
ADediting_509291chr15_90083422_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4252chr1590083417900834237mer-m89008341690083434150-18.78
ADediting_509291chr15_90083422_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6529-3pchr1590083421900834277mer-m89008342090083441141-13.07
ADediting_509291chr15_90083422_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6889-3pchr1590083421900834277mer-m89008342090083439145-17.68
ADediting_509292chr15_90083424_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6529-3pchr1590083421900834277mer-m89008342090083441141-13.07
ADediting_509292chr15_90083424_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-6889-3pchr1590083421900834277mer-m89008342090083439145-17.68

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-5688chr1590083960900839667mer-m89008395990083978152-15.79
ADediting_1337758chr7_5495892_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-589-5pchr1590083766900837727mer-m89008376590083791157-29.95
ADediting_1337758chr7_5495892_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-589-5pchr1590083899900839057mer-m89008389890083918162-25.85
ADediting_286380chr11_79422188_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-5579-3pchr1590084136900841427mer-m89008413590084156154-15.66
ADediting_286380chr11_79422188_-ENSG00000182054.9ENST00000559482.5IDH2-203hsa-miR-5579-3pchr1590084136900841427mer-m89008413590084156154-15.66
ADediting_98288chr1_32086990_+ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-5585-3pchr1590083310900833178mer-1a9008331090083333150-16.28

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_496066chr15_66496985_-ENSG00000182054.9ENST00000330062.7IDH2-201hsa-miR-4512chr1590083919900839257mer-m89008391890083937151-23.3

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for IDH2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000330062.7protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_509246ENST00000330062.7chr15_90083162_-2577-1047.40-1047.40-1107.80
ADediting_509247ENST00000330062.7chr15_90083163_-2576-1047.40-1047.40-1107.80
ADediting_509248ENST00000330062.7chr15_90083168_-2571-1046.70-1047.40-1107.80
ADediting_509249ENST00000330062.7chr15_90083170_-2569-1048.10-1047.40-1107.80
ADediting_509250ENST00000330062.7chr15_90083190_-2549-1048.40-1047.40-1107.80
ADediting_509251ENST00000330062.7chr15_90083193_-2546-1047.00-1047.40-1107.80
ADediting_509252ENST00000330062.7chr15_90083200_-2539-1047.40-1047.40-1107.80
ADediting_509253ENST00000330062.7chr15_90083205_-2534-1047.40-1047.40-1107.80
ADediting_509254ENST00000330062.7chr15_90083209_-2530-1046.70-1047.40-1107.80
ADediting_509255ENST00000330062.7chr15_90083218_-2521-1046.70-1047.40-1107.80
ADediting_509256ENST00000330062.7chr15_90083229_-2510-1049.90-1047.40-1107.80
ADediting_509257ENST00000330062.7chr15_90083230_-2509-1053.30-1047.40-1107.80
ADediting_509258ENST00000330062.7chr15_90083238_-2501-1053.30-1047.40-1107.80
ADediting_509259ENST00000330062.7chr15_90083239_-2500-1048.50-1047.40-1107.80
ADediting_509260ENST00000330062.7chr15_90083240_-2499-1048.50-1047.40-1107.80
ADediting_509261ENST00000330062.7chr15_90083241_-2498-1049.70-1047.40-1107.80
ADediting_509262ENST00000330062.7chr15_90083244_-2495-1048.00-1047.40-1107.80
ADediting_509263ENST00000330062.7chr15_90083261_-2478-1047.70-1047.40-1107.80
ADediting_509264ENST00000330062.7chr15_90083265_-2474-1047.40-1047.40-1107.80
ADediting_509265ENST00000330062.7chr15_90083271_-2468-1046.60-1047.40-1107.80
ADediting_509266ENST00000330062.7chr15_90083277_-2462-1047.00-1047.40-1107.80
ADediting_509267ENST00000330062.7chr15_90083293_-2446-1046.60-1047.40-1107.80
ADediting_509268ENST00000330062.7chr15_90083297_-2442-1047.30-1047.40-1107.80
ADediting_509269ENST00000330062.7chr15_90083301_-2438-1050.20-1047.40-1107.80
ADediting_509270ENST00000330062.7chr15_90083303_-2436-1050.30-1047.40-1107.80
ADediting_509271ENST00000330062.7chr15_90083306_-2433-1047.40-1047.40-1107.80
ADediting_509272ENST00000330062.7chr15_90083308_-2431-1053.20-1047.40-1107.80
ADediting_509273ENST00000330062.7chr15_90083309_-2430-1047.40-1047.40-1107.80
ADediting_509274ENST00000330062.7chr15_90083310_-2429-1047.40-1047.40-1107.80
ADediting_509275ENST00000330062.7chr15_90083315_-2424-1050.70-1047.40-1107.80
ADediting_509276ENST00000330062.7chr15_90083321_-2418-1044.00-1047.40-1107.80
ADediting_509277ENST00000330062.7chr15_90083326_-2413-1047.00-1047.40-1107.80
ADediting_509278ENST00000330062.7chr15_90083328_-2411-1045.90-1047.40-1107.80
ADediting_509279ENST00000330062.7chr15_90083334_-2405-1047.40-1047.40-1107.80
ADediting_509280ENST00000330062.7chr15_90083336_-2403-1047.80-1047.40-1107.80
ADediting_509281ENST00000330062.7chr15_90083337_-2402-1048.70-1047.40-1107.80
ADediting_509282ENST00000330062.7chr15_90083346_-2393-1048.20-1047.40-1107.80
ADediting_509283ENST00000330062.7chr15_90083349_-2390-1046.90-1047.40-1107.80
ADediting_509284ENST00000330062.7chr15_90083351_-2388-1047.40-1047.40-1107.80
ADediting_1623543ENST00000330062.7chr15_90083357_-2382-1050.20-1047.40-1107.80
ADediting_509285ENST00000330062.7chr15_90083360_-2379-1046.70-1047.40-1107.80
ADediting_509286ENST00000330062.7chr15_90083365_-2374-1048.80-1047.40-1107.80
ADediting_509287ENST00000330062.7chr15_90083370_-2369-1047.00-1047.40-1107.80
ADediting_509288ENST00000330062.7chr15_90083405_-2334-1048.20-1047.40-1107.80
ADediting_509289ENST00000330062.7chr15_90083406_-2333-1049.90-1047.40-1107.80
ADediting_509290ENST00000330062.7chr15_90083408_-2331-1047.10-1047.40-1107.80
ADediting_509291ENST00000330062.7chr15_90083422_-2317-1047.00-1047.40-1107.80
ADediting_509292ENST00000330062.7chr15_90083424_-2315-1047.80-1047.40-1107.80

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for IDH2

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_509350chr15_90096862_-0.2841324136753820.06102319724170430.425585649411806-0.045413501419239.93716447453155e-150.420733138245726

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC2.15119614882926e-180.469424390643585.47701455060214e-090.323587988617135.57357003719807e-540.735352726024747
AC1.05643066770196e-530.7859484388067773.15447681777586e-270.6133554919287141.44279356047115e-290.634481449472244
PCC2.83292618751467e-140.5140488280425722.23486015056202e-080.3910167703152421.02255841179996e-100.445849086293341
TCX4.66878590190848e-110.5044132714279280.05162614873727810.1592263470477049.89786988179363e-050.312485311379958
FP1.02652478909081e-140.5375097310182461.43770964044375e-060.3520968262282062.48701142523692e-070.375090567570903
IFG0.0006436088857343450.6353469257750130.06036444061748690.3808256543288070.2335448427539280.247191219720453
STG5.76765936212887e-160.743135305645963.82465264696349e-070.5207101817677180.0002112534441026220.393709417637642

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Relation with AD stages for IDH2

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
IFGADediting_509268chr15_90083297_-0.0449220351546537-0.404459265579513

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
TCX0.001549074025172430.30374742412615

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RelatedDrugs for IDH2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
IDH2P48735DB13874EnasidenibIsocitrate dehydrogenase [NADP], mitochondrialsmall moleculeapproved|investigational

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RelatedDiseases for IDH2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
IDH2C0751396Well Differentiated Oligodendroglioma3CTD_human;UNIPROT
IDH2C0004114Astrocytoma2UNIPROT
IDH2C0007193Cardiomyopathy, Dilated2GENOMICS_ENGLAND
IDH2C0014084Enchondromatosis2CTD_human;ORPHANET
IDH2C0014474Ependymoma2UNIPROT
IDH2C0023467Leukemia, Myelocytic, Acute2CGI;CTD_human
IDH2C0024454Maffucci Syndrome2CTD_human;ORPHANET
IDH2C0026998Acute Myeloid Leukemia, M12CTD_human
IDH2C0079774Peripheral T-Cell Lymphoma2CTD_human
IDH2C0206725Subependymal Glioma2UNIPROT
IDH2C0264886Conduction disorder of the heart2GENOMICS_ENGLAND
IDH2C0543888Epileptic encephalopathy2GENOMICS_ENGLAND
IDH2C0936248Chondroma2CTD_human
IDH2C1621958Glioblastoma Multiforme2CGI;UNIPROT
IDH2C1704356Enchondroma2CTD_human
IDH2C1842010Glioma of Brain, Familial2UNIPROT
IDH2C1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
IDH2C2750850GLIOMA SUSCEPTIBILITY 12UNIPROT
IDH2C3714756Intellectual Disability2GENOMICS_ENGLAND
IDH2C0001787Osteoporosis, Age-Related1CTD_human
IDH2C0007194Hypertrophic Cardiomyopathy1CTD_human
IDH2C0007682CNS disorder1CTD_human
IDH2C0018273Growth Disorders1CTD_human
IDH2C0018800Cardiomegaly1CTD_human
IDH2C0018916Hemangioma1CTD_human
IDH2C0020295Hydronephrosis1CTD_human
IDH2C0020981Angioimmunoblastic Lymphadenopathy1CTD_human
IDH2C0022333Jacksonian Seizure1CTD_human
IDH2C0023487Acute Promyelocytic Leukemia1CTD_human
IDH2C0027643Neoplasm Recurrence, Local1CTD_human
IDH2C0028945oligodendroglioma1CTD_human;ORPHANET
IDH2C0029408Degenerative polyarthritis1CTD_human
IDH2C0029456Osteoporosis1CTD_human
IDH2C0029459Osteoporosis, Senile1CTD_human
IDH2C0035078Kidney Failure1CTD_human
IDH2C0036572Seizures1CTD_human
IDH2C0086743Osteoarthrosis Deformans1CTD_human
IDH2C0149958Complex partial seizures1CTD_human
IDH2C0205788Histiocytoid hemangioma1CTD_human
IDH2C0205789Hemangioma, Intramuscular1CTD_human
IDH2C0206698Cholangiocarcinoma1CGI;CTD_human
IDH2C0234533Generalized seizures1CTD_human
IDH2C0234535Seizures, Clonic1CTD_human
IDH2C0242698Ventricular Dysfunction, Left1CTD_human
IDH2C0270824Visual seizure1CTD_human
IDH2C0270844Tonic Seizures1CTD_human
IDH2C0270846Epileptic drop attack1CTD_human
IDH2C0279070Adult Oligodendroglioma1CTD_human
IDH2C0280475Childhood Oligodendroglioma1CTD_human
IDH2C0280793Mixed Oligodendroglioma-Astrocytoma1CTD_human;ORPHANET
IDH2C0334590Anaplastic Oligodendroglioma1CTD_human;ORPHANET
IDH2C0344461Oligodendroblastoma1CTD_human
IDH2C0345905Intrahepatic Cholangiocarcinoma1CTD_human
IDH2C0376634Craniofacial Abnormalities1CTD_human
IDH2C0422850Seizures, Somatosensory1CTD_human
IDH2C0422852Seizures, Auditory1CTD_human
IDH2C0422853Olfactory seizure1CTD_human
IDH2C0422854Gustatory seizure1CTD_human
IDH2C0422855Vertiginous seizure1CTD_human
IDH2C0494475Tonic - clonic seizures1CTD_human
IDH2C0677608Chorioangioma1CTD_human
IDH2C0751056Non-epileptic convulsion1CTD_human
IDH2C0751110Single Seizure1CTD_human
IDH2C0751123Atonic Absence Seizures1CTD_human
IDH2C0751395Mixed Oligodendroglioma-Ependymoma1CTD_human
IDH2C0751406Post-Traumatic Osteoporosis1CTD_human
IDH2C0751494Convulsive Seizures1CTD_human
IDH2C0751495Seizures, Focal1CTD_human
IDH2C0751496Seizures, Sensory1CTD_human
IDH2C1383860Cardiac Hypertrophy1CTD_human
IDH2C1565489Renal Insufficiency1CTD_human
IDH2C1959588Angioma1CTD_human
IDH2C2746066Combined D-2- and L-2-hydroxyglutaric aciduria1CTD_human
IDH2C3150909D-2-HYDROXYGLUTARIC ACIDURIA 21UNIPROT
IDH2C3495874Nonepileptic Seizures1CTD_human
IDH2C3805278Extrahepatic Cholangiocarcinoma1CTD_human
IDH2C4048158Convulsions1CTD_human
IDH2C4316903Absence Seizures1CTD_human
IDH2C4317109Epileptic Seizures1CTD_human
IDH2C4317123Myoclonic Seizures1CTD_human
IDH2C4505436Generalized Absence Seizures1CTD_human