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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for SLC29A2 |
 Gene summary |
| Gene information | Gene symbol | SLC29A2 | Gene ID | 3177 |
| Gene name | solute carrier family 29 member 2 | |
| Synonyms | DER12|ENT2|HNP36 | |
| Cytomap | 11q13.2 | |
| Type of gene | protein-coding | |
| Description | equilibrative nucleoside transporter 236 kDa nucleolar protein HNP36delayed-early response protein 12equilibrative NBMPR-insensitive nucleoside transporterequilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporterhydrophobic | |
| Modification date | 20200313 | |
| UniProtAcc | Q14542, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| SLC29A2 | GO:0015858 | nucleoside transport | 12527552 |
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RNA A-to-I events for SLC29A2 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_269910(66365177, -), ADediting_269911(66365178, -), ADediting_269912(66366883, -), ADediting_269913(66366893, -), |
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RNA editing positional annotations for SLC29A2 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_269910 | chr11_66365177_- | intronic |
| ADediting_269911 | chr11_66365178_- | intronic |
| ADediting_269912 | chr11_66366883_- | intronic |
| ADediting_269913 | chr11_66366893_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_269910 | chr11_66365177_- | SINE | Alu | Name=AluSg |
| ADediting_269911 | chr11_66365178_- | SINE | Alu | Name=AluSg |
| ADediting_269912 | chr11_66366883_- | SINE | Alu | Name=AluJb |
| ADediting_269913 | chr11_66366893_- | SINE | Alu | Name=AluJb |
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RNA A-to-I editing events in the alternative splicing sites for SLC29A2 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SLC29A2 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for SLC29A2 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for SLC29A2 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000174669.12 | ENST00000311161.11 | SLC29A2-201 | hsa-miR-589-3p | chr11 | 66363436 | 66363443 | 8mer-1a | 66363436 | 66363458 | 144 | -19.1 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000174669.12 | ENST00000619145.4 | SLC29A2-207 | hsa-miR-589-3p | chr11 | 66363436 | 66363443 | 8mer-1a | 66363436 | 66363458 | 144 | -19.1 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000174669.12 | ENST00000311161.11 | SLC29A2-201 | hsa-miR-4477b | chr11 | 66362615 | 66362621 | 7mer-m8 | 66362614 | 66362635 | 144 | -8.54 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000174669.12 | ENST00000357440.7 | SLC29A2-202 | hsa-miR-4477b | chr11 | 66362615 | 66362621 | 7mer-m8 | 66362614 | 66362635 | 144 | -8.54 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000174669.12 | ENST00000544554.5 | SLC29A2-205 | hsa-miR-4477b | chr11 | 66362615 | 66362621 | 7mer-m8 | 66362614 | 66362635 | 144 | -8.54 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000174669.12 | ENST00000546034.1 | SLC29A2-206 | hsa-miR-4477b | chr11 | 66362615 | 66362621 | 7mer-m8 | 66362614 | 66362635 | 144 | -8.54 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000174669.12 | ENST00000619145.4 | SLC29A2-207 | hsa-miR-4477b | chr11 | 66362615 | 66362621 | 7mer-m8 | 66362614 | 66362635 | 144 | -8.54 |
| ADediting_496066 | chr15_66496985_- | ENSG00000174669.12 | ENST00000311161.11 | SLC29A2-201 | hsa-miR-4512 | chr11 | 66363323 | 66363329 | 7mer-m8 | 66363322 | 66363341 | 148 | -24.6 |
| ADediting_496066 | chr15_66496985_- | ENSG00000174669.12 | ENST00000357440.7 | SLC29A2-202 | hsa-miR-4512 | chr11 | 66363323 | 66363329 | 7mer-m8 | 66363322 | 66363341 | 148 | -24.6 |
| ADediting_496066 | chr15_66496985_- | ENSG00000174669.12 | ENST00000544554.5 | SLC29A2-205 | hsa-miR-4512 | chr11 | 66363323 | 66363329 | 7mer-m8 | 66363322 | 66363341 | 148 | -24.6 |
| ADediting_496066 | chr15_66496985_- | ENSG00000174669.12 | ENST00000546034.1 | SLC29A2-206 | hsa-miR-4512 | chr11 | 66363323 | 66363329 | 7mer-m8 | 66363322 | 66363341 | 148 | -24.6 |
| ADediting_496066 | chr15_66496985_- | ENSG00000174669.12 | ENST00000619145.4 | SLC29A2-207 | hsa-miR-4512 | chr11 | 66363323 | 66363329 | 7mer-m8 | 66363322 | 66363341 | 148 | -24.6 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_527135 | chr16_24203190_+ | ENSG00000174669.12 | ENST00000311161.11 | SLC29A2-201 | hsa-miR-1273h-3p | chr11 | 66363131 | 66363137 | 7mer-m8 | 66363130 | 66363151 | 143 | -13.44 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000174669.12 | ENST00000357440.7 | SLC29A2-202 | hsa-miR-1273h-3p | chr11 | 66363131 | 66363137 | 7mer-m8 | 66363130 | 66363151 | 143 | -13.44 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000174669.12 | ENST00000544554.5 | SLC29A2-205 | hsa-miR-1273h-3p | chr11 | 66363131 | 66363137 | 7mer-m8 | 66363130 | 66363151 | 143 | -13.44 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000174669.12 | ENST00000546034.1 | SLC29A2-206 | hsa-miR-1273h-3p | chr11 | 66363131 | 66363137 | 7mer-m8 | 66363130 | 66363151 | 143 | -13.44 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000174669.12 | ENST00000619145.4 | SLC29A2-207 | hsa-miR-1273h-3p | chr11 | 66363131 | 66363137 | 7mer-m8 | 66363130 | 66363151 | 143 | -13.44 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for SLC29A2 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for SLC29A2 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_269913 | chr11_66366893_- | 0.084640553122057 | 0.141269251776989 | 5.9391913460866e-05 | 0.32177032663144 | 0.00858582855609715 | 0.213885210438175 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.66841854358036e-14 | 0.417471947513804 | 1.61712098372285e-33 | 0.614073219023651 | 0.000193873959789284 | 0.210152294701971 |
| AC | 7.7157538886252e-31 | 0.645315983787478 | 3.91445466528627e-23 | 0.572106682058647 | 1.08077018787888e-15 | 0.478239609024054 |
| PCC | 8.01002895358556e-15 | 0.523338454397817 | 9.89756299812314e-16 | 0.53811836002346 | 7.18447464088878e-07 | 0.349543051529678 |
| TCX | 2.8018757177121e-06 | 0.371820485253132 | 2.3788355065441e-10 | 0.488025357987504 | 0.0127387129328019 | 0.202964945291885 |
| FP | 8.49826411111789e-08 | 0.38833287242956 | 0.115501924804371 | 0.118390408986036 | 5.01080576940577e-12 | 0.487750314945261 |
| IFG | 0.000810471560681753 | 0.626282113069744 | 0.00016642196104843 | 0.683356785236259 | 0.00974954034369278 | 0.506657041392091 |
| PG | 0.362015381454467 | -0.0672142251469489 | 0.404202837556587 | -0.061518775607128 | 2.00577447345309e-07 | 0.370068626886565 |
| STG | 0.00837476953815593 | 0.285925829121112 | 0.386027273856419 | 0.0957981207233959 | 3.19723269228204e-07 | 0.523664924969393 |
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Relation with AD stages for SLC29A2 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 9.23891547257718e-05 | 0.370533103687561 |
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RelatedDrugs for SLC29A2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| SLC29A2 | Q14542 | DB00898 | Ethanol | Equilibrative nucleoside transporter 2 | small molecule | approved |
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RelatedDiseases for SLC29A2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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