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Center for Computational Systems Medicine
Soverview

Gene summary

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RNA A-to-I events

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Differntial gene expression between RNA A-to-I edited versus non-edited samples

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Protein coding region RNA A-to-I editings

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The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

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Relation with ADAR

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Relation with AD stages

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Related drugs with this gene

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Related diseases with this gene


Gene summary for KCNIP2

check button Gene summary
Gene informationGene symbol

KCNIP2

Gene ID

30819

Gene namepotassium voltage-gated channel interacting protein 2
SynonymsKCHIP2
Cytomap

10q24.32

Type of geneprotein-coding
DescriptionKv channel-interacting protein 2A-type potassium channel modulatory protein 2Kv channel interacting protein 2cardiac voltage-gated potassium channel modulatory subunitpotassium channel-interacting protein 2
Modification date20200320
UniProtAcc

Q9NS61,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
KCNIP2

GO:0045163

clustering of voltage-gated potassium channels

11287421

KCNIP2

GO:0086009

membrane repolarization

21493962

KCNIP2

GO:0097623

potassium ion export across plasma membrane

21493962

KCNIP2

GO:1901379

regulation of potassium ion transmembrane transport

21493962

KCNIP2

GO:1903766

positive regulation of potassium ion export across plasma membrane

21349352


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RNA A-to-I events for KCNIP2

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
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check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
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check button RNA A-to-I editing events in AD.
ADediting_156409(101836310, -), ADediting_156410(101836313, -), ADediting_156411(101836373, -), ADediting_156412(101836378, -), ADediting_156413(101836379, -), ADediting_156414(101836387, -), ADediting_156415(101836405, -), ADediting_156416(101836408, -), ADediting_156417(101836411, -), ADediting_156418(101836416, -), ADediting_156419(101836418, -), ADediting_156420(101836431, -), ADediting_156421(101836432, -), ADediting_156422(101836440, -), ADediting_156423(101836449, -), ADediting_156424(101836452, -), ADediting_156425(101836454, -), ADediting_156426(101836463, -), ADediting_156427(101836478, -), ADediting_156428(101836706, -), ADediting_156429(101836737, -), ADediting_156430(101836769, -), ADediting_156431(101836813, -), ADediting_156432(101836823, -), ADediting_156433(101836826, -), ADediting_156434(101836839, -), ADediting_156435(101836849, -), ADediting_156436(101836861, -), ADediting_156437(101836923, -), ADediting_156438(101837073, -), ADediting_156439(101837075, -), ADediting_156440(101837097, -), ADediting_156441(101837445, -), ADediting_156442(101837481, -), ADediting_156443(101837521, -), ADediting_156444(101837540, -), ADediting_156445(101837541, -), ADediting_156446(101837545, -), ADediting_156447(101837547, -), ADediting_156448(101837625, -), ADediting_156449(101837628, -), ADediting_1522163(101837021, -),

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RNA editing positional annotations for KCNIP2 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_156409chr10_101836310_-intronic
ADediting_156410chr10_101836313_-intronic
ADediting_156411chr10_101836373_-intronic
ADediting_156412chr10_101836378_-intronic
ADediting_156413chr10_101836379_-intronic
ADediting_156414chr10_101836387_-intronic
ADediting_156415chr10_101836405_-intronic
ADediting_156416chr10_101836408_-intronic
ADediting_156417chr10_101836411_-intronic
ADediting_156418chr10_101836416_-intronic
ADediting_156419chr10_101836418_-intronic
ADediting_156420chr10_101836431_-intronic
ADediting_156421chr10_101836432_-intronic
ADediting_156422chr10_101836440_-intronic
ADediting_156423chr10_101836449_-intronic
ADediting_156424chr10_101836452_-intronic
ADediting_156425chr10_101836454_-intronic
ADediting_156426chr10_101836463_-intronic
ADediting_156427chr10_101836478_-intronic
ADediting_156428chr10_101836706_-intronic
ADediting_156429chr10_101836737_-intronic
ADediting_156430chr10_101836769_-intronic
ADediting_156431chr10_101836813_-intronic
ADediting_156432chr10_101836823_-intronic
ADediting_156433chr10_101836826_-intronic
ADediting_156434chr10_101836839_-intronic
ADediting_156435chr10_101836849_-intronic
ADediting_156436chr10_101836861_-intronic
ADediting_156437chr10_101836923_-intronic
ADediting_156438chr10_101837073_-intronic
ADediting_156439chr10_101837075_-intronic
ADediting_156440chr10_101837097_-intronic
ADediting_156441chr10_101837445_-intronic
ADediting_156442chr10_101837481_-intronic
ADediting_156443chr10_101837521_-intronic
ADediting_156444chr10_101837540_-intronic
ADediting_156445chr10_101837541_-intronic
ADediting_156446chr10_101837545_-intronic
ADediting_156447chr10_101837547_-intronic
ADediting_156448chr10_101837625_-intronic
ADediting_156449chr10_101837628_-intronic
ADediting_1522163chr10_101837021_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_156409chr10_101836310_-SINEAluName=AluSz6
ADediting_156410chr10_101836313_-SINEAluName=AluSz6
ADediting_156411chr10_101836373_-SINEAluName=AluSz6
ADediting_156412chr10_101836378_-SINEAluName=AluSz6
ADediting_156413chr10_101836379_-SINEAluName=AluSz6
ADediting_156414chr10_101836387_-SINEAluName=AluSz6
ADediting_156415chr10_101836405_-SINEAluName=AluSz6
ADediting_156416chr10_101836408_-SINEAluName=AluSz6
ADediting_156417chr10_101836411_-SINEAluName=AluSz6
ADediting_156418chr10_101836416_-SINEAluName=AluSz6
ADediting_156419chr10_101836418_-SINEAluName=AluSz6
ADediting_156420chr10_101836431_-SINEAluName=AluSz6
ADediting_156421chr10_101836432_-SINEAluName=AluSz6
ADediting_156422chr10_101836440_-SINEAluName=AluSz6
ADediting_156423chr10_101836449_-SINEAluName=AluSz6
ADediting_156424chr10_101836452_-SINEAluName=AluSz6
ADediting_156425chr10_101836454_-SINEAluName=AluSz6
ADediting_156426chr10_101836463_-SINEAluName=AluSz6
ADediting_156427chr10_101836478_-SINEAluName=AluSz6
ADediting_156428chr10_101836706_-SINEAluName=AluSg
ADediting_156429chr10_101836737_-SINEAluName=AluSg
ADediting_156430chr10_101836769_-SINEAluName=AluSg
ADediting_156431chr10_101836813_-SINEAluName=AluSg
ADediting_156432chr10_101836823_-SINEAluName=AluSg
ADediting_156433chr10_101836826_-SINEAluName=AluSg
ADediting_156434chr10_101836839_-SINEAluName=AluSg
ADediting_156435chr10_101836849_-SINEAluName=AluSg
ADediting_156436chr10_101836861_-SINEAluName=AluSg
ADediting_156437chr10_101836923_-SINEAluName=AluSg
ADediting_156438chr10_101837073_-SINEAluName=AluJr
ADediting_156439chr10_101837075_-SINEAluName=AluJr
ADediting_156440chr10_101837097_-SINEAluName=AluJr
ADediting_156441chr10_101837445_-SINEAluName=AluSg
ADediting_156442chr10_101837481_-SINEAluName=AluSg
ADediting_156443chr10_101837521_-SINEAluName=AluSg
ADediting_156444chr10_101837540_-SINEAluName=AluSg
ADediting_156445chr10_101837541_-SINEAluName=AluSg
ADediting_156446chr10_101837545_-SINEAluName=AluSg
ADediting_156447chr10_101837547_-SINEAluName=AluSg
ADediting_156448chr10_101837625_-SINEAluName=AluSg
ADediting_156449chr10_101837628_-SINEAluName=AluSg
ADediting_1522163chr10_101837021_-SINEAluName=AluJr

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RNA A-to-I editing events in the alternative splicing sites for KCNIP2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for KCNIP2

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for KCNIP2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for KCNIP2


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337758chr7_5495892_-ENSG00000120049.19ENST00000348850.9KCNIP2-203hsa-miR-589-5pchr101018270661018270727mer-m8101827065101827085149-17.27
ADediting_1337758chr7_5495892_-ENSG00000120049.19ENST00000356640.6KCNIP2-206hsa-miR-589-5pchr101018270661018270727mer-m8101827065101827085149-17.27
ADediting_1337758chr7_5495892_-ENSG00000120049.19ENST00000358038.7KCNIP2-207hsa-miR-589-5pchr101018270661018270727mer-m8101827065101827085149-17.27
ADediting_1556067chr19_40282625_-ENSG00000120049.19ENST00000348850.9KCNIP2-203hsa-miR-641chr101018270231018270297mer-m8101827022101827046149-14.1
ADediting_1556067chr19_40282625_-ENSG00000120049.19ENST00000356640.6KCNIP2-206hsa-miR-641chr101018270231018270297mer-m8101827022101827046149-14.1
ADediting_1556067chr19_40282625_-ENSG00000120049.19ENST00000358038.7KCNIP2-207hsa-miR-641chr101018270231018270297mer-m8101827022101827046149-14.1
ADediting_1631458chr19_40282624_-ENSG00000120049.19ENST00000348850.9KCNIP2-203hsa-miR-641chr101018265441018265507mer-m8101826543101826566140-15.46
ADediting_1631458chr19_40282624_-ENSG00000120049.19ENST00000356640.6KCNIP2-206hsa-miR-641chr101018265441018265507mer-m8101826543101826566140-15.46
ADediting_1631458chr19_40282624_-ENSG00000120049.19ENST00000358038.7KCNIP2-207hsa-miR-641chr101018265441018265507mer-m8101826543101826566140-15.46

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for KCNIP2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for KCNIP2

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CERADediting_156415chr10_101836405_-0.005989054099135730.2234292813228751.78622966877295e-050.342493691752940.001937849303280570.251113670144945
CERADediting_156426chr10_101836463_-0.01447429245297160.1993154759123990.0005000042822074750.2808109954574950.0001850008245284150.300681095703738
CERADediting_156427chr10_101836478_-0.0002036178713391810.2988263908706247.6200538555384e-060.3563424806900280.0143118341657350.199640350836745
CERADediting_156429chr10_101836737_-1.13053181818995e-050.3500105578859115.16001378395474e-080.4267585622767590.002340179658649090.246694038228749
CERADediting_156431chr10_101836813_-0.0002178296187401090.2975138519112073.87248873447739e-050.3293189343078830.04349066518083880.16509605889137
CERADediting_156432chr10_101836823_-2.32718095912204e-050.3380563683883031.60295539345583e-060.3801239225863830.02258315460678660.186121980536905
CERADediting_156433chr10_101836826_-4.7206929534152e-050.3258478580537879.31970494206554e-060.3531276470441730.08865399487327740.139498317467715
CERADediting_156434chr10_101836839_-0.0009974599656791780.2660930486617614.18973034099962e-050.327944011616940.007604132140450150.217145731139613
CERADediting_156435chr10_101836849_-0.001903787918137020.2515251931025535.53494992559753e-050.3230282932487550.005585830394500260.225232942242201
CERADediting_156437chr10_101836923_-0.005101605249530510.2275594375580231.23548129439872e-050.3485667269467760.006295584475799970.222129240200517
CERADediting_156440chr10_101837097_-0.003485889025426690.2370948090065828.93616466467481e-050.3143680084826030.24126299213290.0962628951174474
CERADediting_156444chr10_101837540_-0.0001123859956528190.31012773901486.5068784062046e-050.3201329359474150.03710568802220860.170385523013439
CERADediting_156445chr10_101837541_-7.8604306830964e-050.3167129496725779.70192986961917e-050.3128545916787610.04784884918592920.161847988803238
CERADediting_156447chr10_101837547_-0.0002237147584406390.2969935033385523.28638681440652e-050.332163629031120.009533637726386330.211036537801954
CERADediting_156449chr10_101837628_-0.000196529137740820.2995132486804292.91231513002098e-050.3342405200531670.4712903205706960.0592629161968711

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC1.26954991442444e-360.6365596335693369.83820988024385e-650.7802589320621470.0001344342392199360.215182139936773
AC1.36400368069517e-740.8604870924430483.28494949002105e-950.9071542986106430.004550017354776190.178891867490741
PCC2.68870698832437e-400.7797784534760939.63254072601883e-430.7941408426091450.01310973584422380.179223172324977
CER6.52730705175991e-100.4774132874362466.69491716741132e-070.3926650086689190.5959396471491750.0436390358877047
TCX1.48159339514361e-110.515463670368723.1534118304441e-240.7091606634359620.00110514597102449-0.26383643181835
FP6.22615075033538e-330.746270415651542.16585161453401e-350.7644698895099590.008048636653745370.198051468475363
IFG0.0007683078010305390.6284081181601183.89564179607081e-050.7266594476777380.1136105299839530.324415670130435
PG2.67567571462415e-260.677118132437437.06215815064742e-260.6728911376984890.156888633329074-0.104217526480398
STG1.91043803771646e-180.781029332829621.56135440314094e-180.7822450141857960.593026898986692-0.0591489866623304

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Relation with AD stages for KCNIP2

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
CERADediting_156415chr10_101836405_-1.42985586456859e-060.444626454487412
CERADediting_156417chr10_101836411_-0.0006917578426702720.321503097188434
CERADediting_156429chr10_101836737_-7.31684631052757e-050.37213428176907
CERADediting_156432chr10_101836823_-0.0001674011976215620.354456834391413
CERADediting_156434chr10_101836839_-0.0004015063102016670.33457319424004
CERADediting_156437chr10_101836923_-4.12059891994032e-050.383824271725472
CERADediting_156439chr10_101837075_-0.0001821312392719510.352596348349754
CERADediting_156443chr10_101837521_-0.001100103942789820.309877222961142

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.

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RelatedDrugs for KCNIP2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KCNIP2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource