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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

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Relation with AD stages

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Related drugs with this gene

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Related diseases with this gene


Gene summary for DSE

check button Gene summary
Gene informationGene symbol

DSE

Gene ID

29940

Gene namedermatan sulfate epimerase
SynonymsDS-epi1|DSEP|DSEPI|EDSMC2|SART-2|SART2
Cytomap

6q22.1

Type of geneprotein-coding
Descriptiondermatan-sulfate epimeraseDS epimerasechondroitin-glucuronate 5-epimerasesquamous cell carcinoma antigen recognized by T-cells 2
Modification date20200313
UniProtAcc

Q9UL01,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
DSE

GO:0030208

dermatan sulfate biosynthetic process

16505484


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RNA A-to-I events for DSE

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1226768(116293633, +), ADediting_1226769(116293640, +), ADediting_1226770(116293647, +), ADediting_1226771(116293677, +), ADediting_1226772(116293700, +), ADediting_1226773(116293701, +), ADediting_1226774(116293711, +), ADediting_1226775(116293796, +), ADediting_1226776(116293801, +), ADediting_1226777(116293814, +), ADediting_1226778(116293815, +), ADediting_1226779(116293822, +), ADediting_1226780(116293830, +), ADediting_1226781(116293833, +), ADediting_1226782(116293836, +), ADediting_1226783(116293863, +), ADediting_1226784(116293866, +), ADediting_1226785(116294299, +), ADediting_1226786(116303903, +), ADediting_1226787(116303911, +), ADediting_1226788(116303958, +), ADediting_1226789(116304005, +), ADediting_1226790(116304015, +), ADediting_1226791(116304021, +), ADediting_1226792(116304025, +), ADediting_1226793(116304029, +), ADediting_1226794(116304032, +), ADediting_1226795(116304068, +), ADediting_1226796(116304069, +), ADediting_1226797(116304073, +), ADediting_1226798(116304080, +), ADediting_1226799(116304088, +), ADediting_1226800(116304110, +), ADediting_1226801(116305702, +), ADediting_1226802(116305894, +), ADediting_1226803(116305904, +), ADediting_1226804(116311868, +), ADediting_1226805(116311885, +), ADediting_1226806(116311892, +), ADediting_1226807(116313065, +), ADediting_1226808(116329893, +), ADediting_1226809(116330005, +), ADediting_1226810(116330008, +), ADediting_1226811(116330027, +), ADediting_1226812(116330068, +), ADediting_1226813(116331830, +), ADediting_1226814(116331836, +), ADediting_1226815(116331906, +), ADediting_1226816(116331907, +), ADediting_1226817(116347322, +), ADediting_1226818(116347330, +), ADediting_1226819(116409356, +), ADediting_1226820(116409357, +), ADediting_1226821(116409381, +), ADediting_1226822(116409417, +), ADediting_1226823(116409461, +), ADediting_1226824(116409481, +), ADediting_1226825(116410505, +), ADediting_1226826(116410517, +), ADediting_1226827(116410556, +), ADediting_1226828(116410570, +), ADediting_1226829(116410613, +), ADediting_1226830(116410646, +), ADediting_1226831(116410684, +), ADediting_1226832(116428003, +), ADediting_1226833(116428027, +), ADediting_1226834(116428069, +), ADediting_1226835(116428082, +), ADediting_1226836(116430622, +), ADediting_1226837(116430628, +), ADediting_1226838(116430643, +), ADediting_1226839(116430667, +), ADediting_1226840(116430671, +), ADediting_1226841(116430681, +), ADediting_1226842(116430699, +), ADediting_1226843(116430732, +), ADediting_1226844(116430748, +), ADediting_1226845(116439867, +), ADediting_1226846(116439883, +), ADediting_1226847(116439891, +), ADediting_1226848(116440347, +), ADediting_1226849(116440398, +), ADediting_1659114(116294085, +), ADediting_1659115(116294284, +), ADediting_1659116(116294302, +), ADediting_1659117(116311852, +), ADediting_1659118(116311878, +), ADediting_1659119(116311891, +), ADediting_1659120(116313343, +), ADediting_1659121(116329963, +), ADediting_1659122(116329973, +),

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RNA editing positional annotations for DSE using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1226768chr6_116293633_+intronic
ADediting_1226769chr6_116293640_+intronic
ADediting_1226770chr6_116293647_+intronic
ADediting_1226771chr6_116293677_+intronic
ADediting_1226772chr6_116293700_+intronic
ADediting_1226773chr6_116293701_+intronic
ADediting_1226774chr6_116293711_+intronic
ADediting_1226775chr6_116293796_+intronic
ADediting_1226776chr6_116293801_+intronic
ADediting_1226777chr6_116293814_+intronic
ADediting_1226778chr6_116293815_+intronic
ADediting_1226779chr6_116293822_+intronic
ADediting_1226780chr6_116293830_+intronic
ADediting_1226781chr6_116293833_+intronic
ADediting_1226782chr6_116293836_+intronic
ADediting_1226783chr6_116293863_+intronic
ADediting_1226784chr6_116293866_+intronic
ADediting_1226785chr6_116294299_+intronic
ADediting_1226786chr6_116303903_+intronic
ADediting_1226787chr6_116303911_+intronic
ADediting_1226788chr6_116303958_+intronic
ADediting_1226789chr6_116304005_+intronic
ADediting_1226790chr6_116304015_+intronic
ADediting_1226791chr6_116304021_+intronic
ADediting_1226792chr6_116304025_+intronic
ADediting_1226793chr6_116304029_+intronic
ADediting_1226794chr6_116304032_+intronic
ADediting_1226795chr6_116304068_+intronic
ADediting_1226796chr6_116304069_+intronic
ADediting_1226797chr6_116304073_+intronic
ADediting_1226798chr6_116304080_+intronic
ADediting_1226799chr6_116304088_+intronic
ADediting_1226800chr6_116304110_+intronic
ADediting_1226801chr6_116305702_+intronic
ADediting_1226802chr6_116305894_+intronic
ADediting_1226803chr6_116305904_+intronic
ADediting_1226804chr6_116311868_+intronic
ADediting_1226805chr6_116311885_+intronic
ADediting_1226806chr6_116311892_+intronic
ADediting_1226807chr6_116313065_+intronic
ADediting_1226808chr6_116329893_+intronic
ADediting_1226809chr6_116330005_+intronic
ADediting_1226810chr6_116330008_+intronic
ADediting_1226811chr6_116330027_+intronic
ADediting_1226812chr6_116330068_+intronic
ADediting_1226813chr6_116331830_+intronic
ADediting_1226814chr6_116331836_+intronic
ADediting_1226815chr6_116331906_+intronic
ADediting_1226816chr6_116331907_+intronic
ADediting_1226817chr6_116347322_+intronic
ADediting_1226818chr6_116347330_+intronic
ADediting_1226819chr6_116409356_+intronic
ADediting_1226820chr6_116409357_+intronic
ADediting_1226821chr6_116409381_+intronic
ADediting_1226822chr6_116409417_+intronic
ADediting_1226823chr6_116409461_+intronic
ADediting_1226824chr6_116409481_+intronic
ADediting_1226825chr6_116410505_+intronic
ADediting_1226826chr6_116410517_+intronic
ADediting_1226827chr6_116410556_+intronic
ADediting_1226828chr6_116410570_+intronic
ADediting_1226829chr6_116410613_+intronic
ADediting_1226830chr6_116410646_+intronic
ADediting_1226831chr6_116410684_+intronic
ADediting_1226832chr6_116428003_+intronic
ADediting_1226833chr6_116428027_+intronic
ADediting_1226834chr6_116428069_+intronic
ADediting_1226835chr6_116428082_+intronic
ADediting_1226836chr6_116430622_+intronic
ADediting_1226837chr6_116430628_+intronic
ADediting_1226838chr6_116430643_+intronic
ADediting_1226839chr6_116430667_+intronic
ADediting_1226840chr6_116430671_+intronic
ADediting_1226841chr6_116430681_+intronic
ADediting_1226842chr6_116430699_+intronic
ADediting_1226843chr6_116430732_+intronic
ADediting_1226844chr6_116430748_+intronic
ADediting_1226845chr6_116439867_+UTR3
ADediting_1226846chr6_116439883_+UTR3
ADediting_1226847chr6_116439891_+UTR3
ADediting_1226848chr6_116440347_+UTR3
ADediting_1226849chr6_116440398_+UTR3
ADediting_1659114chr6_116294085_+intronic
ADediting_1659115chr6_116294284_+intronic
ADediting_1659116chr6_116294302_+intronic
ADediting_1659117chr6_116311852_+intronic
ADediting_1659118chr6_116311878_+intronic
ADediting_1659119chr6_116311891_+intronic
ADediting_1659120chr6_116313343_+intronic
ADediting_1659121chr6_116329963_+intronic
ADediting_1659122chr6_116329973_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1226768chr6_116293633_+SINEAluName=AluJo
ADediting_1226769chr6_116293640_+SINEAluName=AluJo
ADediting_1226770chr6_116293647_+SINEAluName=AluJo
ADediting_1226771chr6_116293677_+SINEAluName=AluJo
ADediting_1226772chr6_116293700_+SINEAluName=AluJo
ADediting_1226773chr6_116293701_+SINEAluName=AluJo
ADediting_1226774chr6_116293711_+SINEAluName=AluJo
ADediting_1226775chr6_116293796_+SINEAluName=AluJo
ADediting_1226776chr6_116293801_+SINEAluName=AluJo
ADediting_1226777chr6_116293814_+SINEAluName=AluJo
ADediting_1226778chr6_116293815_+SINEAluName=AluJo
ADediting_1226779chr6_116293822_+SINEAluName=AluJo
ADediting_1226780chr6_116293830_+SINEAluName=AluJo
ADediting_1226781chr6_116293833_+SINEAluName=AluJo
ADediting_1226782chr6_116293836_+SINEAluName=AluJo
ADediting_1226783chr6_116293863_+SINEAluName=AluJo
ADediting_1226784chr6_116293866_+SINEAluName=AluJo
ADediting_1226785chr6_116294299_+SINEAluName=AluJo
ADediting_1226786chr6_116303903_+SINEAluName=AluY
ADediting_1226787chr6_116303911_+SINEAluName=AluY
ADediting_1226788chr6_116303958_+SINEAluName=AluY
ADediting_1226789chr6_116304005_+SINEAluName=AluY
ADediting_1226790chr6_116304015_+SINEAluName=AluY
ADediting_1226791chr6_116304021_+SINEAluName=AluY
ADediting_1226792chr6_116304025_+SINEAluName=AluY
ADediting_1226793chr6_116304029_+SINEAluName=AluY
ADediting_1226794chr6_116304032_+SINEAluName=AluY
ADediting_1226795chr6_116304068_+SINEAluName=AluY
ADediting_1226796chr6_116304069_+SINEAluName=AluY
ADediting_1226797chr6_116304073_+SINEAluName=AluY
ADediting_1226798chr6_116304080_+SINEAluName=AluY
ADediting_1226799chr6_116304088_+SINEAluName=AluY
ADediting_1226800chr6_116304110_+SINEAluName=AluY
ADediting_1226801chr6_116305702_+SINEAluName=AluSq2
ADediting_1226802chr6_116305894_+SINEAluName=AluSq2
ADediting_1226803chr6_116305904_+SINEAluName=AluSq2
ADediting_1226804chr6_116311868_+LINEL2Name=L2a
ADediting_1226805chr6_116311885_+LINEL2Name=L2a
ADediting_1226806chr6_116311892_+LINEL2Name=L2a
ADediting_1226807chr6_116313065_+LTRERVL-MaLRName=MLT1C
ADediting_1226808chr6_116329893_+SINEAluName=AluSx1
ADediting_1226809chr6_116330005_+SINEAluName=AluSx1
ADediting_1226810chr6_116330008_+SINEAluName=AluSx1
ADediting_1226811chr6_116330027_+SINEAluName=AluSx1
ADediting_1226812chr6_116330068_+SINEAluName=AluSx1
ADediting_1226813chr6_116331830_+SINEAluName=AluSc
ADediting_1226814chr6_116331836_+SINEAluName=AluSc
ADediting_1226815chr6_116331906_+SINEAluName=AluSc
ADediting_1226816chr6_116331907_+SINEAluName=AluSc
ADediting_1226817chr6_116347322_+LINEL1Name=L1PA5
ADediting_1226818chr6_116347330_+LINEL1Name=L1PA5
ADediting_1226819chr6_116409356_+SINEAluName=AluY
ADediting_1226820chr6_116409357_+SINEAluName=AluY
ADediting_1226821chr6_116409381_+SINEAluName=AluY
ADediting_1226822chr6_116409417_+SINEAluName=AluY
ADediting_1226823chr6_116409461_+SINEAluName=AluY
ADediting_1226824chr6_116409481_+SINEAluName=AluY
ADediting_1226825chr6_116410505_+SINEAluName=AluY
ADediting_1226826chr6_116410517_+SINEAluName=AluY
ADediting_1226827chr6_116410556_+SINEAluName=AluY
ADediting_1226828chr6_116410570_+SINEAluName=AluY
ADediting_1226829chr6_116410613_+SINEAluName=AluY
ADediting_1226830chr6_116410646_+SINEAluName=AluY
ADediting_1226831chr6_116410684_+SINEAluName=AluY
ADediting_1226832chr6_116428003_+SINEAluName=AluSz
ADediting_1226833chr6_116428027_+SINEAluName=AluSz
ADediting_1226834chr6_116428069_+SINEAluName=AluSz
ADediting_1226835chr6_116428082_+SINEAluName=AluSz
ADediting_1226836chr6_116430622_+SINEAluName=AluY
ADediting_1226837chr6_116430628_+SINEAluName=AluY
ADediting_1226838chr6_116430643_+SINEAluName=AluY
ADediting_1226839chr6_116430667_+SINEAluName=AluY
ADediting_1226840chr6_116430671_+SINEAluName=AluY
ADediting_1226841chr6_116430681_+SINEAluName=AluY
ADediting_1226842chr6_116430699_+SINEAluName=AluY
ADediting_1226843chr6_116430732_+SINEAluName=AluY
ADediting_1226844chr6_116430748_+SINEAluName=AluY
ADediting_1226845chr6_116439867_+SINEAluName=AluJr
ADediting_1226846chr6_116439883_+SINEAluName=AluJr
ADediting_1226847chr6_116439891_+SINEAluName=AluJr
ADediting_1226848chr6_116440347_+SINEAluName=AluJo
ADediting_1226849chr6_116440398_+SINEAluName=AluJo
ADediting_1659114chr6_116294085_+SINEAluName=AluJo
ADediting_1659115chr6_116294284_+SINEAluName=AluJo
ADediting_1659116chr6_116294302_+SINEAluName=AluJo
ADediting_1659117chr6_116311852_+LINEL2Name=L2a
ADediting_1659118chr6_116311878_+LINEL2Name=L2a
ADediting_1659119chr6_116311891_+LINEL2Name=L2a
ADediting_1659120chr6_116313343_+LTRERVL-MaLRName=MLT1C
ADediting_1659121chr6_116329963_+SINEAluName=AluSx1
ADediting_1659122chr6_116329973_+SINEAluName=AluSx1

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RNA A-to-I editing events in the alternative splicing sites for DSE

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for DSE

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for DSE

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for DSE

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1226845chr6_116439867_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-150-5pchr61164398641164398707mer-m8116439849116439871143-15.38
ADediting_1226845chr6_116439867_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-150-5pchr61164398641164398707mer-m8116439849116439871143-15.38
ADediting_1226845chr6_116439867_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-150-5pchr61164398641164398707mer-m8116439849116439871143-15.38
ADediting_1226847chr6_116439891_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-12122chr61164398881164398947mer-m8116439869116439895157-18.27
ADediting_1226847chr6_116439891_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-12122chr61164398881164398947mer-m8116439869116439895157-18.27
ADediting_1226847chr6_116439891_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-12122chr61164398881164398947mer-m8116439869116439895157-18.27
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-508-5pchr61164403431164403497mer-m8116440328116440350149-19.96
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-6512-3pchr61164403411164403477mer-m8116440327116440348145-18.84
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-6720-5pchr61164403411164403477mer-m8116440327116440348155-23.71
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-6849-3pchr61164403401164403478mer-1a116440326116440347152-18.75
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-766-3pchr61164403421164403487mer-m8116440328116440349145-20.34
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-508-5pchr61164403431164403497mer-m8116440328116440350149-19.96
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-6512-3pchr61164403411164403477mer-m8116440327116440348145-18.84
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-6720-5pchr61164403411164403477mer-m8116440327116440348155-23.71
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-6849-3pchr61164403401164403478mer-1a116440326116440347152-18.75
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-766-3pchr61164403421164403487mer-m8116440328116440349145-20.34
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-508-5pchr61164403431164403497mer-m8116440328116440350149-19.96
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-6512-3pchr61164403411164403477mer-m8116440327116440348145-18.84
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-6720-5pchr61164403411164403477mer-m8116440327116440348155-23.71
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-6849-3pchr61164403401164403478mer-1a116440326116440347152-18.75
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-766-3pchr61164403421164403487mer-m8116440328116440349145-20.34

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1226846chr6_116439883_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-1184chr61164398771164398837mer-m8116439863116439884146-18.45
ADediting_1226846chr6_116439883_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-4418chr61164398781164398847mer-m8116439868116439885152-20.79
ADediting_1226846chr6_116439883_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-509-3-5pchr61164398781164398847mer-m8116439865116439885153-18.35
ADediting_1226846chr6_116439883_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-509-5pchr61164398781164398847mer-m8116439864116439885151-19.74
ADediting_1226846chr6_116439883_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-1184chr61164398771164398837mer-m8116439863116439884146-18.45
ADediting_1226846chr6_116439883_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-4418chr61164398781164398847mer-m8116439868116439885152-20.79
ADediting_1226846chr6_116439883_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-509-3-5pchr61164398781164398847mer-m8116439865116439885153-18.35
ADediting_1226846chr6_116439883_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-509-5pchr61164398781164398847mer-m8116439864116439885151-19.74
ADediting_1226846chr6_116439883_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-1184chr61164398771164398837mer-m8116439863116439884146-18.45
ADediting_1226846chr6_116439883_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-4418chr61164398781164398847mer-m8116439868116439885152-20.79
ADediting_1226846chr6_116439883_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-509-3-5pchr61164398781164398847mer-m8116439865116439885153-18.35
ADediting_1226846chr6_116439883_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-509-5pchr61164398781164398847mer-m8116439864116439885151-19.74
ADediting_1226847chr6_116439891_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-7705chr61164398851164398917mer-m8116439873116439892148-15.02
ADediting_1226847chr6_116439891_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-7705chr61164398851164398917mer-m8116439873116439892148-15.02
ADediting_1226847chr6_116439891_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-7705chr61164398851164398917mer-m8116439873116439892148-15.02
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-3157-5pchr61164403411164403477mer-1a116440326116440347143-22.37
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-3157-5pchr61164403411164403477mer-1a116440326116440347143-22.37
ADediting_1226848chr6_116440347_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-3157-5pchr61164403411164403477mer-1a116440326116440347143-22.37
ADediting_1226849chr6_116440398_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-4720-3pchr61164403931164403997mer-m8116440382116440400148-13.18
ADediting_1226849chr6_116440398_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-4720-3pchr61164403931164403997mer-m8116440382116440400148-13.18
ADediting_1226849chr6_116440398_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-4720-3pchr61164403931164403997mer-m8116440382116440400148-13.18

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_107020chr1_37500952_-ENSG00000111817.17ENST00000359564.3DSE-202hsa-miR-5581-3pchr61164371141164371207mer-m8116437099116437121155-21.97
ADediting_107020chr1_37500952_-ENSG00000111817.17ENST00000646710.1DSE-216hsa-miR-5581-3pchr61164371141164371207mer-m8116437099116437121155-21.97
ADediting_1097295chr3_85385762_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-5688chr61164390281164390347mer-m8116439014116439035140-9.81
ADediting_1097295chr3_85385762_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-5688chr61164390281164390347mer-m8116439014116439035140-9.81
ADediting_1097295chr3_85385762_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-5688chr61164390281164390347mer-m8116439014116439035140-9.81
ADediting_1391023chr8_140732605_-ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-151a-3pchr61164375911164375977mer-m8116437578116437598140-14.12
ADediting_1391023chr8_140732605_-ENSG00000111817.17ENST00000359564.3DSE-202hsa-miR-151a-3pchr61164375911164375977mer-m8116437578116437598140-14.12
ADediting_1391023chr8_140732605_-ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-151a-3pchr61164375911164375977mer-m8116437578116437598140-14.12
ADediting_1391023chr8_140732605_-ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-151a-3pchr61164375911164375977mer-m8116437578116437598140-14.12
ADediting_1391023chr8_140732605_-ENSG00000111817.17ENST00000646710.1DSE-216hsa-miR-151a-3pchr61164375911164375977mer-m8116437578116437598140-14.12
ADediting_1471004chr9_63819627_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-4477bchr61164432671164432737mer-m8116443251116443274155-16.54
ADediting_1471004chr9_63819627_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-4477bchr61164432671164432737mer-m8116443251116443274155-16.54
ADediting_1535953chr14_101045971_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-381-3pchr61164380321164380387mer-m8116438016116438039150-18.22
ADediting_1535953chr14_101045971_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-381-3pchr61164388541164388618mer-1a116438840116438861142-13.61
ADediting_1535953chr14_101045971_+ENSG00000111817.17ENST00000359564.3DSE-202hsa-miR-381-3pchr61164380321164380387mer-m8116438016116438039150-18.22
ADediting_1535953chr14_101045971_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-381-3pchr61164380321164380387mer-m8116438016116438039150-18.22
ADediting_1535953chr14_101045971_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-381-3pchr61164388541164388618mer-1a116438840116438861142-13.61
ADediting_1535953chr14_101045971_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-381-3pchr61164412751164412828mer-1a116441260116441282152-13.94
ADediting_1535953chr14_101045971_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-381-3pchr61164380321164380387mer-m8116438016116438039150-18.22
ADediting_1535953chr14_101045971_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-381-3pchr61164388541164388618mer-1a116438840116438861142-13.61
ADediting_1535953chr14_101045971_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-381-3pchr61164412751164412828mer-1a116441260116441282152-13.94
ADediting_1535953chr14_101045971_+ENSG00000111817.17ENST00000646710.1DSE-216hsa-miR-381-3pchr61164380321164380387mer-m8116438016116438039150-18.22
ADediting_291761chr11_93733708_-ENSG00000111817.17ENST00000359564.3DSE-202hsa-miR-1304-3pchr61164362151164362217mer-m8116436201116436222162-18.21
ADediting_291761chr11_93733708_-ENSG00000111817.17ENST00000359564.3DSE-202hsa-miR-1304-3pchr61164363391164363468mer-1a116436325116436346165-29.84
ADediting_291761chr11_93733708_-ENSG00000111817.17ENST00000646710.1DSE-216hsa-miR-1304-3pchr61164362151164362217mer-m8116436201116436222162-18.21
ADediting_291761chr11_93733708_-ENSG00000111817.17ENST00000646710.1DSE-216hsa-miR-1304-3pchr61164363391164363468mer-1a116436325116436346165-29.84
ADediting_496066chr15_66496985_-ENSG00000111817.17ENST00000359564.3DSE-202hsa-miR-4512chr61164371431164371497mer-1a116437128116437149140-19.09
ADediting_496066chr15_66496985_-ENSG00000111817.17ENST00000646710.1DSE-216hsa-miR-4512chr61164371431164371497mer-1a116437128116437149140-19.09

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_107020chr1_37500952_-ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-5581-3pchr61164390371164390437mer-m8116439023116439044142-10.8
ADediting_107020chr1_37500952_-ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-5581-3pchr61164390371164390437mer-m8116439023116439044142-10.8
ADediting_107020chr1_37500952_-ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-5581-3pchr61164390371164390437mer-m8116439023116439044142-10.8
ADediting_1337757chr7_5495852_-ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-589-3pchr61164401031164401097mer-m8116440091116440110143-19.6
ADediting_1337757chr7_5495852_-ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-589-3pchr61164401031164401097mer-m8116440091116440110143-19.6
ADediting_1337757chr7_5495852_-ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-589-3pchr61164401031164401097mer-m8116440091116440110143-19.6
ADediting_1471003chr9_63819626_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-4477bchr61164394661164394738mer-1a116439452116439473148-8.71
ADediting_1471003chr9_63819626_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-4477bchr61164394661164394738mer-1a116439452116439473148-8.71
ADediting_1471003chr9_63819626_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-4477bchr61164445941164446007mer-m8116444583116444601143-8.34
ADediting_1471003chr9_63819626_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-4477bchr61164394661164394738mer-1a116439452116439473148-8.71
ADediting_1471003chr9_63819626_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-4477bchr61164445941164446007mer-m8116444583116444601143-8.34
ADediting_1471004chr9_63819627_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-4477bchr61164394661164394738mer-1a116439452116439473148-8.71
ADediting_1471004chr9_63819627_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-4477bchr61164394661164394738mer-1a116439452116439473148-8.71
ADediting_1471004chr9_63819627_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-4477bchr61164445941164446007mer-m8116444583116444601143-8.34
ADediting_1471004chr9_63819627_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-4477bchr61164394661164394738mer-1a116439452116439473148-8.71
ADediting_1471004chr9_63819627_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-4477bchr61164445941164446007mer-m8116444583116444601143-8.34
ADediting_1556067chr19_40282625_-ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-641chr61164402151164402228mer-1a116440199116440222150-13.97
ADediting_1556067chr19_40282625_-ENSG00000111817.17ENST00000359564.3DSE-202hsa-miR-641chr61164372661164372727mer-m8116437250116437273140-12.4
ADediting_1556067chr19_40282625_-ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-641chr61164402151164402228mer-1a116440199116440222150-13.97
ADediting_1556067chr19_40282625_-ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-641chr61164402151164402228mer-1a116440199116440222150-13.97
ADediting_1556067chr19_40282625_-ENSG00000111817.17ENST00000646710.1DSE-216hsa-miR-641chr61164372661164372727mer-m8116437250116437273140-12.4
ADediting_1596844chr1_162342605_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-556-3pchr61164438641164438718mer-1a116443850116443871155-11.68
ADediting_1596844chr1_162342605_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-556-3pchr61164438641164438718mer-1a116443850116443871155-11.68
ADediting_1631458chr19_40282624_-ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-641chr61164402151164402228mer-1a116440199116440222150-13.97
ADediting_1631458chr19_40282624_-ENSG00000111817.17ENST00000359564.3DSE-202hsa-miR-641chr61164372661164372727mer-m8116437250116437273140-12.4
ADediting_1631458chr19_40282624_-ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-641chr61164402151164402228mer-1a116440199116440222150-13.97
ADediting_1631458chr19_40282624_-ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-641chr61164402151164402228mer-1a116440199116440222150-13.97
ADediting_1631458chr19_40282624_-ENSG00000111817.17ENST00000646710.1DSE-216hsa-miR-641chr61164372661164372727mer-m8116437250116437273140-12.4
ADediting_1643790chr3_121049689_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-5682chr61164415751164415817mer-m8116441561116441582145-13.44
ADediting_1643790chr3_121049689_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-5682chr61164415751164415817mer-m8116441561116441582145-13.44
ADediting_496066chr15_66496985_-ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-4512chr61164421551164421617mer-m8116442138116442162144-21.93
ADediting_496066chr15_66496985_-ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-4512chr61164421551164421617mer-m8116442138116442162144-21.93
ADediting_843620chr2_207754818_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-4775chr61164391921164391987mer-m8116439178116439199154-5.31
ADediting_843620chr2_207754818_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-4775chr61164394191164394257mer-m8116439402116439426149-7.13
ADediting_843620chr2_207754818_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-4775chr61164402951164403017mer-m8116440281116440302151-6.07
ADediting_843620chr2_207754818_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-4775chr61164391921164391987mer-m8116439178116439199154-5.31
ADediting_843620chr2_207754818_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-4775chr61164394191164394257mer-m8116439402116439426149-7.13
ADediting_843620chr2_207754818_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-4775chr61164402951164403017mer-m8116440281116440302151-6.07
ADediting_843620chr2_207754818_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-4775chr61164445711164445788mer-1a116444557116444578140-6.48
ADediting_843620chr2_207754818_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-4775chr61164391921164391987mer-m8116439178116439199154-5.31
ADediting_843620chr2_207754818_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-4775chr61164394191164394257mer-m8116439402116439426149-7.13
ADediting_843620chr2_207754818_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-4775chr61164402951164403017mer-m8116440281116440302151-6.07
ADediting_843620chr2_207754818_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-4775chr61164445711164445788mer-1a116444557116444578140-6.48
ADediting_98288chr1_32086990_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-5585-3pchr61164379021164379087mer-m8116437888116437909147-19.58
ADediting_98288chr1_32086990_+ENSG00000111817.17ENST00000359564.3DSE-202hsa-miR-5585-3pchr61164379021164379087mer-m8116437888116437909147-19.58
ADediting_98288chr1_32086990_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-5585-3pchr61164379021164379087mer-m8116437888116437909147-19.58
ADediting_98288chr1_32086990_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-5585-3pchr61164379021164379087mer-m8116437888116437909147-19.58
ADediting_98288chr1_32086990_+ENSG00000111817.17ENST00000646710.1DSE-216hsa-miR-5585-3pchr61164379021164379087mer-m8116437888116437909147-19.58
ADediting_98289chr1_32086992_+ENSG00000111817.17ENST00000331677.7DSE-201hsa-miR-5585-3pchr61164379021164379087mer-m8116437888116437909147-19.58
ADediting_98289chr1_32086992_+ENSG00000111817.17ENST00000359564.3DSE-202hsa-miR-5585-3pchr61164379021164379087mer-m8116437888116437909147-19.58
ADediting_98289chr1_32086992_+ENSG00000111817.17ENST00000452085.7DSE-206hsa-miR-5585-3pchr61164379021164379087mer-m8116437888116437909147-19.58
ADediting_98289chr1_32086992_+ENSG00000111817.17ENST00000644252.1DSE-213hsa-miR-5585-3pchr61164379021164379087mer-m8116437888116437909147-19.58
ADediting_98289chr1_32086992_+ENSG00000111817.17ENST00000646710.1DSE-216hsa-miR-5585-3pchr61164379021164379087mer-m8116437888116437909147-19.58

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for DSE

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000452085.7protein_codingSoverviewSoverview
ENST00000331677.7protein_codingSoverviewSoverview
ENST00000644252.1protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_1226845ENST00000452085.7chr6_116439867_+5593-2949.90-2945.30-2959.70
ADediting_1226846ENST00000452085.7chr6_116439883_+5609-2944.60-2945.30-2959.70
ADediting_1226847ENST00000452085.7chr6_116439891_+5617-2942.30-2945.30-2959.70
ADediting_1226848ENST00000452085.7chr6_116440347_+6073-2952.20-2945.30-2959.70
ADediting_1226849ENST00000452085.7chr6_116440398_+6124-2951.90-2945.30-2959.70
ADediting_1226845ENST00000331677.7chr6_116439867_+5843-2078.00-2073.40-2087.80
ADediting_1226846ENST00000331677.7chr6_116439883_+5859-2072.70-2073.40-2087.80
ADediting_1226847ENST00000331677.7chr6_116439891_+5867-2070.40-2073.40-2087.80
ADediting_1226848ENST00000331677.7chr6_116440347_+6323-2080.30-2073.40-2087.80
ADediting_1226849ENST00000331677.7chr6_116440398_+6374-2080.00-2073.40-2087.80
ADediting_1226845ENST00000644252.1chr6_116439867_+5627-2996.10-2991.50-3005.90
ADediting_1226846ENST00000644252.1chr6_116439883_+5643-2990.80-2991.50-3005.90
ADediting_1226847ENST00000644252.1chr6_116439891_+5651-2988.50-2991.50-3005.90
ADediting_1226848ENST00000644252.1chr6_116440347_+6107-2998.40-2991.50-3005.90
ADediting_1226849ENST00000644252.1chr6_116440398_+6158-2998.10-2991.50-3005.90

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for DSE

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC1.82616022991453e-130.4019345612492130.0001361876715088950.2150060981320340.0130031678830310.140928304058095
AC1.60638072050501e-360.6889060530616681.21833222493919e-190.5316389501861971.74269458572822e-170.503648225325571
PCC0.07705466792051090.128243740373140.1315669137291210.1095019769797179.20487576695514e-090.400752782761307
CER1.72979499614875e-180.6376101583980956.73152896937124e-130.543385099383048.42583512169667e-060.354741903886795
TCX5.42118303261946e-090.4539050837828460.754251091412580.02577086011060732.21276930215054e-090.464073801858106
FP1.16214898644742e-120.5002449079320391.54380952433336e-160.5671298169458621.23597330925973e-050.321171560786457
IFG0.04137847886005010.4107669830511170.01671906233725820.4738493419307940.02654238680663090.443066727895365
PG6.5494478095457e-260.673221915652378.25063468255114e-170.5609750459608850.07253032321978650.131985718359817
STG0.001371750829681030.343655202067260.03358862941705160.2321546937929493.39033461432769e-050.435997646260757

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Relation with AD stages for DSE

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER2.77402370441038e-070.470499110550276
TCX3.48792614004622e-120.611078014268936

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RelatedDrugs for DSE

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DSE

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
DSEC0013720Ehlers-Danlos Syndrome5GENOMICS_ENGLAND
DSEC3809845EHLERS-DANLOS SYNDROME, MUSCULOCONTRACTURAL TYPE, 21CTD_human;UNIPROT