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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for SNX12 |
 Gene summary |
| Gene information | Gene symbol | SNX12 | Gene ID | 29934 |
| Gene name | sorting nexin 12 | |
| Synonyms | - | |
| Cytomap | Xq13.1 | |
| Type of gene | protein-coding | |
| Description | sorting nexin-12 | |
| Modification date | 20200313 | |
| UniProtAcc | Q9UMY4, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| SNX12 | GO:0010955 | negative regulation of protein processing | 22709416 |
| SNX12 | GO:0042177 | negative regulation of protein catabolic process | 22719997 |
| SNX12 | GO:0051224 | negative regulation of protein transport | 22719997 |
| SNX12 | GO:2000642 | negative regulation of early endosome to late endosome transport | 22719997 |
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RNA A-to-I events for SNX12 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1506243(71056353, -), ADediting_1506244(71057714, -), ADediting_1506245(71057739, -), ADediting_1506246(71057767, -), ADediting_1506247(71057772, -), ADediting_1506248(71057789, -), ADediting_1506249(71057790, -), ADediting_1506250(71057796, -), ADediting_1506251(71057803, -), ADediting_1506252(71057813, -), ADediting_1506253(71057832, -), ADediting_1506254(71057841, -), ADediting_1506255(71057900, -), ADediting_1506256(71057914, -), ADediting_1506257(71057946, -), ADediting_1506258(71057947, -), ADediting_1506259(71057955, -), ADediting_1506260(71057973, -), ADediting_1506261(71058429, -), ADediting_1506262(71058433, -), ADediting_1506263(71058435, -), ADediting_1506264(71058447, -), ADediting_1506265(71058461, -), ADediting_1506266(71058466, -), ADediting_1506267(71058480, -), ADediting_1506268(71058484, -), ADediting_1506269(71058506, -), ADediting_1506270(71058507, -), |
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RNA editing positional annotations for SNX12 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_1506243 | chrX_71056353_- | synonymous SNV | ENST00000622259.4 | c.A498G | p.P166P | . | . | . |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1506243 | chrX_71056353_- | exonic |
| ADediting_1506244 | chrX_71057714_- | intronic |
| ADediting_1506245 | chrX_71057739_- | intronic |
| ADediting_1506246 | chrX_71057767_- | intronic |
| ADediting_1506247 | chrX_71057772_- | intronic |
| ADediting_1506248 | chrX_71057789_- | intronic |
| ADediting_1506249 | chrX_71057790_- | intronic |
| ADediting_1506250 | chrX_71057796_- | intronic |
| ADediting_1506251 | chrX_71057803_- | intronic |
| ADediting_1506252 | chrX_71057813_- | intronic |
| ADediting_1506253 | chrX_71057832_- | intronic |
| ADediting_1506254 | chrX_71057841_- | intronic |
| ADediting_1506255 | chrX_71057900_- | intronic |
| ADediting_1506256 | chrX_71057914_- | intronic |
| ADediting_1506257 | chrX_71057946_- | intronic |
| ADediting_1506258 | chrX_71057947_- | intronic |
| ADediting_1506259 | chrX_71057955_- | intronic |
| ADediting_1506260 | chrX_71057973_- | intronic |
| ADediting_1506261 | chrX_71058429_- | intronic |
| ADediting_1506262 | chrX_71058433_- | intronic |
| ADediting_1506263 | chrX_71058435_- | intronic |
| ADediting_1506264 | chrX_71058447_- | intronic |
| ADediting_1506265 | chrX_71058461_- | intronic |
| ADediting_1506266 | chrX_71058466_- | intronic |
| ADediting_1506267 | chrX_71058480_- | intronic |
| ADediting_1506268 | chrX_71058484_- | intronic |
| ADediting_1506269 | chrX_71058506_- | intronic |
| ADediting_1506270 | chrX_71058507_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1506243 | chrX_71056353_- | SINE | Alu | Name=AluSz |
| ADediting_1506244 | chrX_71057714_- | SINE | Alu | Name=AluJo |
| ADediting_1506245 | chrX_71057739_- | SINE | Alu | Name=AluJo |
| ADediting_1506246 | chrX_71057767_- | SINE | Alu | Name=AluJo |
| ADediting_1506247 | chrX_71057772_- | SINE | Alu | Name=AluJo |
| ADediting_1506248 | chrX_71057789_- | SINE | Alu | Name=AluJo |
| ADediting_1506249 | chrX_71057790_- | SINE | Alu | Name=AluJo |
| ADediting_1506250 | chrX_71057796_- | SINE | Alu | Name=AluJo |
| ADediting_1506251 | chrX_71057803_- | SINE | Alu | Name=AluJo |
| ADediting_1506252 | chrX_71057813_- | SINE | Alu | Name=AluJo |
| ADediting_1506253 | chrX_71057832_- | SINE | Alu | Name=AluJo |
| ADediting_1506254 | chrX_71057841_- | SINE | Alu | Name=AluJo |
| ADediting_1506255 | chrX_71057900_- | SINE | Alu | Name=AluJo |
| ADediting_1506256 | chrX_71057914_- | SINE | Alu | Name=AluJo |
| ADediting_1506257 | chrX_71057946_- | SINE | Alu | Name=AluJo |
| ADediting_1506258 | chrX_71057947_- | SINE | Alu | Name=AluJo |
| ADediting_1506259 | chrX_71057955_- | SINE | Alu | Name=AluJo |
| ADediting_1506261 | chrX_71058429_- | SINE | Alu | Name=AluJr4 |
| ADediting_1506262 | chrX_71058433_- | SINE | Alu | Name=AluJr4 |
| ADediting_1506263 | chrX_71058435_- | SINE | Alu | Name=AluJr4 |
| ADediting_1506264 | chrX_71058447_- | SINE | Alu | Name=AluJr4 |
| ADediting_1506265 | chrX_71058461_- | SINE | Alu | Name=AluJr4 |
| ADediting_1506266 | chrX_71058466_- | SINE | Alu | Name=AluJr4 |
| ADediting_1506267 | chrX_71058480_- | SINE | Alu | Name=AluJr4 |
| ADediting_1506268 | chrX_71058484_- | SINE | Alu | Name=AluJr4 |
| ADediting_1506269 | chrX_71058506_- | SINE | Alu | Name=AluJr4 |
| ADediting_1506270 | chrX_71058507_- | SINE | Alu | Name=AluJr4 |
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RNA A-to-I editing events in the alternative splicing sites for SNX12 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SNX12 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for SNX12 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for SNX12 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000147164.12 | ENST00000374274.8 | SNX12-202 | hsa-miR-4477b | chrX | 71060241 | 71060247 | 7mer-m8 | 71060240 | 71060261 | 140 | -12.63 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000147164.12 | ENST00000622277.4 | SNX12-207 | hsa-miR-4477b | chrX | 71060241 | 71060247 | 7mer-m8 | 71060240 | 71060261 | 140 | -12.63 |
| ADediting_496066 | chr15_66496985_- | ENSG00000147164.12 | ENST00000374274.8 | SNX12-202 | hsa-miR-4512 | chrX | 71059359 | 71059366 | 8mer-1a | 71059359 | 71059380 | 156 | -22.2 |
| ADediting_496066 | chr15_66496985_- | ENSG00000147164.12 | ENST00000622277.4 | SNX12-207 | hsa-miR-4512 | chrX | 71059359 | 71059366 | 8mer-1a | 71059359 | 71059380 | 156 | -22.2 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000147164.12 | ENST00000374274.8 | SNX12-202 | hsa-miR-5688 | chrX | 71059773 | 71059779 | 7mer-m8 | 71059772 | 71059797 | 154 | -19.97 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000147164.12 | ENST00000622277.4 | SNX12-207 | hsa-miR-5688 | chrX | 71059773 | 71059779 | 7mer-m8 | 71059772 | 71059797 | 154 | -19.97 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for SNX12 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000622259.4 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1506243 | ENST00000622259.4 | chrX_71056353_- | 640 | -247.60 | -245.50 | -247.60 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for SNX12 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| STG | ADediting_1506248 | chrX_71057789_- | 0.062114453215014 | 0.204448116709668 | 0.00199681909464512 | 0.332553266402266 | 0.0192645486069665 | -0.254940537385056 |
| CER | ADediting_1506251 | chrX_71057803_- | 4.07991761133487e-05 | 0.328408524472819 | 3.54620260177962e-11 | 0.507097409192473 | 0.115543054394384 | 0.129038575580184 |
| CER | ADediting_1506264 | chrX_71058447_- | 0.00561912443506291 | 0.22507968540013 | 5.90383722695921e-06 | 0.360367322498908 | 0.0381544498627461 | 0.16946667588186 |
| CER | ADediting_1506265 | chrX_71058461_- | 0.000102171410915058 | 0.311897979538151 | 1.0484163410599e-05 | 0.351231471860203 | 0.00220691024421251 | 0.24807598407803 |
| CER | ADediting_1506267 | chrX_71058480_- | 4.18370827665106e-06 | 0.365714423936106 | 5.17389324402484e-14 | 0.564750355860574 | 0.00259752553719196 | 0.244216176780458 |
| TCX | ADediting_1506267 | chrX_71058480_- | 0.0576050583284307 | 0.155384408271227 | 1.24731313225373e-06 | 0.38378073761384 | 0.0614194141287423 | -0.15310185079844 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.06793139007998e-68 | 0.794528310868454 | 8.87316878623799e-83 | 0.837361748138488 | 0.0953252100506057 | 0.0949027796889523 |
| AC | 3.16393660311811e-94 | 0.905354948728713 | 2.95823119206006e-55 | 0.792814485232901 | 4.62689312080397e-18 | 0.511383138006249 |
| PCC | 2.35342955211631e-59 | 0.867970710922889 | 3.4461031341033e-58 | 0.863875366920577 | 0.0570364841392395 | 0.137944989227623 |
| CER | 8.42249351930374e-51 | 0.884265552453502 | 3.05285339352704e-25 | 0.719898474986864 | 0.0230925067597136 | 0.185439274962342 |
| TCX | 1.08430163804419e-54 | 0.898191654978845 | 5.58537613800281e-21 | 0.671146486185626 | 0.123840815266612 | 0.12619943371703 |
| FP | 1.00018622677858e-15 | 0.554303561568749 | 5.86565229786168e-26 | 0.68463669073439 | 0.551460029586891 | 0.044934155636499 |
| IFG | 1.08277322524934e-07 | 0.84486703761708 | 4.01184213991187e-05 | 0.725855167522263 | 0.52197987485929 | 0.134355108614223 |
| PG | 1.07490204692862e-41 | 0.794370314188227 | 7.40021604378341e-34 | 0.742549101263426 | 0.612916278558753 | -0.0373342367275325 |
| STG | 5.41052867096735e-18 | 0.774632215624551 | 1.61427746295842e-15 | 0.735512598352627 | 0.678977642526221 | -0.0458184887641706 |
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Relation with AD stages for SNX12 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_1506265 | chrX_71058461_- | 0.000111849009706206 | 0.363198081550889 |
| CER | ADediting_1506267 | chrX_71058480_- | 2.34903193786149e-05 | 0.394852525496893 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for SNX12 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SNX12 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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