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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for GUCA1B

check button Gene summary
Gene informationGene symbol

GUCA1B

Gene ID

2979

Gene nameguanylate cyclase activator 1B
SynonymsGCAP 2|GCAP2|GUCA2|RP48
Cytomap

6p21.1

Type of geneprotein-coding
Descriptionguanylyl cyclase-activating protein 2guanylate cyclase activator 1B (retina)guanylate cyclase-activating protein, photoreceptor 2
Modification date20200313
UniProtAcc

Q9UMX6,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for GUCA1B

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1264382(42184200, -), ADediting_1264383(42184228, -), ADediting_1264384(42184296, -), ADediting_1264385(42184320, -), ADediting_1264386(42184363, -), ADediting_1264387(42186330, -), ADediting_1264388(42186444, -), ADediting_1264389(42186445, -), ADediting_1264390(42186449, -), ADediting_1264391(42186469, -), ADediting_1264392(42186510, -), ADediting_1264393(42186511, -), ADediting_1264394(42186536, -), ADediting_1264395(42186559, -), ADediting_1264396(42186587, -), ADediting_1264397(42187177, -), ADediting_1264398(42187201, -), ADediting_1264399(42187245, -), ADediting_1264400(42187377, -), ADediting_1264401(42187920, -), ADediting_1264402(42188078, -), ADediting_1264403(42188982, -), ADediting_1264404(42189009, -), ADediting_1264405(42189034, -), ADediting_1264406(42192093, -), ADediting_1264407(42192099, -), ADediting_1264408(42192111, -), ADediting_1264409(42192112, -), ADediting_1264410(42192130, -), ADediting_1264411(42192134, -), ADediting_1264412(42192137, -), ADediting_1264413(42192171, -), ADediting_1264414(42192188, -), ADediting_1264415(42192191, -), ADediting_1264416(42192197, -), ADediting_1264417(42192206, -), ADediting_1264418(42192210, -), ADediting_1264419(42192242, -), ADediting_1264420(42192271, -), ADediting_1264421(42192272, -), ADediting_1264422(42192278, -), ADediting_1264423(42192291, -), ADediting_1264424(42192310, -), ADediting_1264425(42192449, -), ADediting_1264426(42192455, -), ADediting_1264427(42192469, -), ADediting_1264428(42192482, -), ADediting_1264429(42192520, -), ADediting_1264430(42192529, -), ADediting_1264431(42192542, -), ADediting_1264432(42192543, -), ADediting_1264433(42192546, -), ADediting_1264434(42192549, -), ADediting_1264435(42192555, -), ADediting_1264436(42192580, -), ADediting_1264437(42192582, -), ADediting_1264438(42192588, -), ADediting_1264439(42192590, -), ADediting_1264440(42192596, -), ADediting_1264441(42192626, -), ADediting_1264442(42192629, -), ADediting_1264443(42192650, -), ADediting_1264444(42192655, -), ADediting_1264445(42192660, -), ADediting_1264446(42192681, -), ADediting_1264447(42192705, -), ADediting_1264448(42192759, -), ADediting_1264449(42192769, -), ADediting_1264450(42192779, -), ADediting_1264451(42192783, -), ADediting_1264452(42192790, -), ADediting_1264453(42192791, -), ADediting_1264454(42192796, -), ADediting_1264455(42192815, -), ADediting_1264456(42192840, -), ADediting_1264457(42192858, -), ADediting_1264458(42192874, -), ADediting_1264459(42194076, -), ADediting_1583849(42184284, -), ADediting_1583850(42184286, -), ADediting_1583851(42184328, -), ADediting_1583852(42189056, -), ADediting_1583853(42189064, -), ADediting_1583854(42192458, -), ADediting_1583855(42192712, -), ADediting_1583856(42192767, -), ADediting_1583857(42192809, -), ADediting_1583858(42192878, -), ADediting_1661614(42192292, -),

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RNA editing positional annotations for GUCA1B using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1264382chr6_42184200_-UTR3
ADediting_1264383chr6_42184228_-UTR3
ADediting_1264384chr6_42184296_-UTR3
ADediting_1264385chr6_42184320_-UTR3
ADediting_1264386chr6_42184363_-UTR3
ADediting_1264387chr6_42186330_-intronic
ADediting_1264388chr6_42186444_-intronic
ADediting_1264389chr6_42186445_-intronic
ADediting_1264390chr6_42186449_-intronic
ADediting_1264391chr6_42186469_-intronic
ADediting_1264392chr6_42186510_-intronic
ADediting_1264393chr6_42186511_-intronic
ADediting_1264394chr6_42186536_-intronic
ADediting_1264395chr6_42186559_-intronic
ADediting_1264396chr6_42186587_-intronic
ADediting_1264397chr6_42187177_-intronic
ADediting_1264398chr6_42187201_-intronic
ADediting_1264399chr6_42187245_-intronic
ADediting_1264400chr6_42187377_-intronic
ADediting_1264401chr6_42187920_-intronic
ADediting_1264402chr6_42188078_-intronic
ADediting_1264403chr6_42188982_-intronic
ADediting_1264404chr6_42189009_-intronic
ADediting_1264405chr6_42189034_-intronic
ADediting_1264406chr6_42192093_-intronic
ADediting_1264407chr6_42192099_-intronic
ADediting_1264408chr6_42192111_-intronic
ADediting_1264409chr6_42192112_-intronic
ADediting_1264410chr6_42192130_-intronic
ADediting_1264411chr6_42192134_-intronic
ADediting_1264412chr6_42192137_-intronic
ADediting_1264413chr6_42192171_-intronic
ADediting_1264414chr6_42192188_-intronic
ADediting_1264415chr6_42192191_-intronic
ADediting_1264416chr6_42192197_-intronic
ADediting_1264417chr6_42192206_-intronic
ADediting_1264418chr6_42192210_-intronic
ADediting_1264419chr6_42192242_-intronic
ADediting_1264420chr6_42192271_-intronic
ADediting_1264421chr6_42192272_-intronic
ADediting_1264422chr6_42192278_-intronic
ADediting_1264423chr6_42192291_-intronic
ADediting_1264424chr6_42192310_-intronic
ADediting_1264425chr6_42192449_-intronic
ADediting_1264426chr6_42192455_-intronic
ADediting_1264427chr6_42192469_-intronic
ADediting_1264428chr6_42192482_-intronic
ADediting_1264429chr6_42192520_-intronic
ADediting_1264430chr6_42192529_-intronic
ADediting_1264431chr6_42192542_-intronic
ADediting_1264432chr6_42192543_-intronic
ADediting_1264433chr6_42192546_-intronic
ADediting_1264434chr6_42192549_-intronic
ADediting_1264435chr6_42192555_-intronic
ADediting_1264436chr6_42192580_-intronic
ADediting_1264437chr6_42192582_-intronic
ADediting_1264438chr6_42192588_-intronic
ADediting_1264439chr6_42192590_-intronic
ADediting_1264440chr6_42192596_-intronic
ADediting_1264441chr6_42192626_-intronic
ADediting_1264442chr6_42192629_-intronic
ADediting_1264443chr6_42192650_-intronic
ADediting_1264444chr6_42192655_-intronic
ADediting_1264445chr6_42192660_-intronic
ADediting_1264446chr6_42192681_-intronic
ADediting_1264447chr6_42192705_-intronic
ADediting_1264448chr6_42192759_-intronic
ADediting_1264449chr6_42192769_-intronic
ADediting_1264450chr6_42192779_-intronic
ADediting_1264451chr6_42192783_-intronic
ADediting_1264452chr6_42192790_-intronic
ADediting_1264453chr6_42192791_-intronic
ADediting_1264454chr6_42192796_-intronic
ADediting_1264455chr6_42192815_-intronic
ADediting_1264456chr6_42192840_-intronic
ADediting_1264457chr6_42192858_-intronic
ADediting_1264458chr6_42192874_-intronic
ADediting_1264459chr6_42194076_-intronic
ADediting_1583849chr6_42184284_-UTR3
ADediting_1583850chr6_42184286_-UTR3
ADediting_1583851chr6_42184328_-UTR3
ADediting_1583852chr6_42189056_-intronic
ADediting_1583853chr6_42189064_-intronic
ADediting_1583854chr6_42192458_-intronic
ADediting_1583855chr6_42192712_-intronic
ADediting_1583856chr6_42192767_-intronic
ADediting_1583857chr6_42192809_-intronic
ADediting_1583858chr6_42192878_-intronic
ADediting_1661614chr6_42192292_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1264382chr6_42184200_-SINEAluName=AluYe5
ADediting_1264383chr6_42184228_-SINEAluName=AluYe5
ADediting_1264384chr6_42184296_-SINEAluName=AluYe5
ADediting_1264385chr6_42184320_-SINEAluName=AluYe5
ADediting_1264386chr6_42184363_-SINEAluName=AluYe5
ADediting_1264387chr6_42186330_-SINEAluName=AluSx1
ADediting_1264388chr6_42186444_-SINEAluName=AluSx1
ADediting_1264389chr6_42186445_-SINEAluName=AluSx1
ADediting_1264390chr6_42186449_-SINEAluName=AluSx1
ADediting_1264391chr6_42186469_-SINEAluName=AluSx1
ADediting_1264392chr6_42186510_-SINEAluName=AluSx1
ADediting_1264393chr6_42186511_-SINEAluName=AluSx1
ADediting_1264394chr6_42186536_-SINEAluName=AluSx1
ADediting_1264395chr6_42186559_-SINEAluName=AluSx1
ADediting_1264396chr6_42186587_-SINEAluName=AluSx1
ADediting_1264397chr6_42187177_-SINEAluName=AluYf1
ADediting_1264398chr6_42187201_-SINEAluName=AluYf1
ADediting_1264399chr6_42187245_-SINEAluName=AluYf1
ADediting_1264400chr6_42187377_-SINEAluName=AluYf1
ADediting_1264401chr6_42187920_-SINEAluName=AluJr
ADediting_1264402chr6_42188078_-SINEAluName=AluJr
ADediting_1264403chr6_42188982_-SINEAluName=FLAM_C
ADediting_1264404chr6_42189009_-SINEAluName=FLAM_C
ADediting_1264405chr6_42189034_-SINEAluName=FLAM_C
ADediting_1264406chr6_42192093_-SINEAluName=AluSc
ADediting_1264407chr6_42192099_-SINEAluName=AluSc
ADediting_1264408chr6_42192111_-SINEAluName=AluSc
ADediting_1264409chr6_42192112_-SINEAluName=AluSc
ADediting_1264410chr6_42192130_-SINEAluName=AluSc
ADediting_1264411chr6_42192134_-SINEAluName=AluSc
ADediting_1264412chr6_42192137_-SINEAluName=AluSc
ADediting_1264413chr6_42192171_-SINEAluName=AluSc
ADediting_1264414chr6_42192188_-SINEAluName=AluSc
ADediting_1264415chr6_42192191_-SINEAluName=AluSc
ADediting_1264416chr6_42192197_-SINEAluName=AluSc
ADediting_1264417chr6_42192206_-SINEAluName=AluSc
ADediting_1264418chr6_42192210_-SINEAluName=AluSc
ADediting_1264419chr6_42192242_-SINEAluName=AluSc
ADediting_1264420chr6_42192271_-SINEAluName=AluSc
ADediting_1264421chr6_42192272_-SINEAluName=AluSc
ADediting_1264422chr6_42192278_-SINEAluName=AluSc
ADediting_1264423chr6_42192291_-SINEAluName=AluSc
ADediting_1264424chr6_42192310_-SINEAluName=AluSc
ADediting_1264425chr6_42192449_-SINEAluName=AluSz
ADediting_1264426chr6_42192455_-SINEAluName=AluSz
ADediting_1264427chr6_42192469_-SINEAluName=AluSz
ADediting_1264428chr6_42192482_-SINEAluName=AluSz
ADediting_1264429chr6_42192520_-SINEAluName=AluSz
ADediting_1264430chr6_42192529_-SINEAluName=AluSz
ADediting_1264431chr6_42192542_-SINEAluName=AluSz
ADediting_1264432chr6_42192543_-SINEAluName=AluSz
ADediting_1264433chr6_42192546_-SINEAluName=AluSz
ADediting_1264434chr6_42192549_-SINEAluName=AluSz
ADediting_1264435chr6_42192555_-SINEAluName=AluSz
ADediting_1264436chr6_42192580_-SINEAluName=AluSz
ADediting_1264437chr6_42192582_-SINEAluName=AluSz
ADediting_1264438chr6_42192588_-SINEAluName=AluSz
ADediting_1264439chr6_42192590_-SINEAluName=AluSz
ADediting_1264440chr6_42192596_-SINEAluName=AluSz
ADediting_1264441chr6_42192626_-SINEAluName=AluSz
ADediting_1264442chr6_42192629_-SINEAluName=AluSz
ADediting_1264443chr6_42192650_-SINEAluName=AluSz
ADediting_1264444chr6_42192655_-SINEAluName=AluSz
ADediting_1264445chr6_42192660_-SINEAluName=AluSz
ADediting_1264446chr6_42192681_-SINEAluName=AluSz
ADediting_1264447chr6_42192705_-SINEAluName=AluSz
ADediting_1264448chr6_42192759_-SINEAluName=AluJb
ADediting_1264449chr6_42192769_-SINEAluName=AluJb
ADediting_1264450chr6_42192779_-SINEAluName=AluJb
ADediting_1264451chr6_42192783_-SINEAluName=AluJb
ADediting_1264452chr6_42192790_-SINEAluName=AluJb
ADediting_1264453chr6_42192791_-SINEAluName=AluJb
ADediting_1264454chr6_42192796_-SINEAluName=AluJb
ADediting_1264455chr6_42192815_-SINEAluName=AluJb
ADediting_1264456chr6_42192840_-SINEAluName=AluJb
ADediting_1264457chr6_42192858_-SINEAluName=AluJb
ADediting_1264458chr6_42192874_-SINEAluName=AluJb
ADediting_1264459chr6_42194076_-LINECR1Name=L3
ADediting_1583849chr6_42184284_-SINEAluName=AluYe5
ADediting_1583850chr6_42184286_-SINEAluName=AluYe5
ADediting_1583851chr6_42184328_-SINEAluName=AluYe5
ADediting_1583852chr6_42189056_-SINEAluName=FLAM_C
ADediting_1583853chr6_42189064_-SINEAluName=FLAM_C
ADediting_1583854chr6_42192458_-SINEAluName=AluSz
ADediting_1583856chr6_42192767_-SINEAluName=AluJb
ADediting_1583857chr6_42192809_-SINEAluName=AluJb
ADediting_1583858chr6_42192878_-SINEAluName=AluJb
ADediting_1661614chr6_42192292_-SINEAluName=AluSc

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RNA A-to-I editing events in the alternative splicing sites for GUCA1B

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GUCA1B

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for GUCA1B

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for GUCA1B

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1264382chr6_42184200_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-1976chr642184196421842038mer-1a4218419642184216153-25.04
ADediting_1264382chr6_42184200_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-6747-3pchr642184198421842058mer-1a4218419842184220149-23.42
ADediting_1264383chr6_42184228_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-140-3pchr642184226421842327mer-m84218422542184245147-22.25
ADediting_1264386chr6_42184363_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-8052chr642184358421843647mer-1a4218435842184376140-24.15
ADediting_1583849chr6_42184284_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-412-3pchr642184284421842907mer-m84218428342184303154-22.83
ADediting_1583849chr6_42184284_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-4508chr642184279421842857mer-m84218427842184294142-23.56
ADediting_1583849chr6_42184284_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-6754-3pchr642184284421842907mer-m84218428342184305147-16.57
ADediting_1583850chr6_42184286_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-23a-5pchr642184281421842877mer-m84218428042184301140-18.37
ADediting_1583850chr6_42184286_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-23b-5pchr642184281421842877mer-m84218428042184302141-16.15

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1264382chr6_42184200_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-3152-5pchr642184200421842067mer-m84218419942184222147-13.61
ADediting_1264382chr6_42184200_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-4753-3pchr642184195421842017mer-1a4218419542184216148-27.44
ADediting_1264383chr6_42184228_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-7151-3pchr642184228421842347mer-m84218422742184247140-19.09
ADediting_1264383chr6_42184228_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-8052chr642184222421842287mer-1a4218422242184242141-23.11
ADediting_1264384chr6_42184296_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-3152-3pchr642184293421842997mer-m84218429242184312145-18.08
ADediting_1264385chr6_42184320_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-378a-5pchr642184317421843237mer-m84218431642184337153-23.97
ADediting_1264386chr6_42184363_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-10399-5pchr642184362421843687mer-m84218436142184382144-11.21
ADediting_1264386chr6_42184363_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-5089-5pchr642184358421843647mer-m84218435742184379148-14.13
ADediting_1264386chr6_42184363_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-6504-3pchr642184362421843687mer-m84218436142184382148-14.35
ADediting_1583849chr6_42184284_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-193b-5pchr642184280421842867mer-m84218427942184300142-18.12
ADediting_1583850chr6_42184286_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-6802-3pchr642184285421842928mer-1a4218428542184307150-15.84

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337757chr7_5495852_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-589-3pchr642183857421838637mer-m84218385642183879144-21.21
ADediting_1471004chr9_63819627_+ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-4477bchr642183627421836337mer-m84218362642183648147-15.88
ADediting_843620chr2_207754818_+ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-4775chr642184254421842607mer-m84218425342184274162-12.64

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1556067chr19_40282625_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-641chr642183612421836187mer-m84218361142183633150-12.69
ADediting_1631458chr19_40282624_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-641chr642183612421836187mer-m84218361142183633150-12.69
ADediting_291761chr11_93733708_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-1304-3pchr642183598421836047mer-m84218359742183617152-17.9
ADediting_291761chr11_93733708_-ENSG00000112599.9ENST00000230361.4GUCA1B-201hsa-miR-1304-3pchr642184118421841258mer-1a4218411842184139152-19.39

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GUCA1B

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000230361.4protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_1264382ENST00000230361.4chr6_42184200_-1354-866.80-866.40-873.20
ADediting_1264383ENST00000230361.4chr6_42184228_-1326-868.60-866.40-873.20
ADediting_1583849ENST00000230361.4chr6_42184284_-1270-866.70-866.40-873.20
ADediting_1583850ENST00000230361.4chr6_42184286_-1268-866.40-866.40-873.20
ADediting_1264384ENST00000230361.4chr6_42184296_-1258-866.80-866.40-873.20
ADediting_1264385ENST00000230361.4chr6_42184320_-1234-865.70-866.40-873.20
ADediting_1583851ENST00000230361.4chr6_42184328_-1226-866.80-866.40-873.20
ADediting_1264386ENST00000230361.4chr6_42184363_-1191-866.40-866.40-873.20

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for GUCA1B

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_1264394chr6_42186536_-0.2378340595799070.06723896141677650.9874651765887530.0008959279593701724.406381026004e-080.304695010428403
DLPFCADediting_1264406chr6_42192093_-0.01778331326333830.1345435110525970.1898440854738750.07465974184772996.46695816490459e-090.322129803035756

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC1.16894438423406e-080.3168700764084241.0800322006433e-110.3734119971281217.26622735007568e-140.40801414906207
AC2.1944029079269e-300.6414986390611434.91573734511259e-210.5484544310936962.0291083135885e-120.425577931406049
PCC4.40746601022948e-090.4086042651330924.08064354862157e-100.4326737931669540.01461377073675010.176452976796426
TCX0.005688745557529690.2247618133274390.4621350830739260.06049093015462181.18039606910882e-060.384578657821878
FP6.26451631272123e-080.3919896169577960.0002731580838776460.2696227418644967.86766540645761e-070.360201473957224
STG0.04200943924749440.2224104248133530.3933526218691130.09433587116231990.001654395919328130.338166156700965

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Relation with AD stages for GUCA1B

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.

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RelatedDrugs for GUCA1B

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GUCA1B

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
GUCA1BC0035334Retinitis Pigmentosa1CTD_human;ORPHANET
GUCA1BC3151190RETINITIS PIGMENTOSA 481CTD_human;UNIPROT