ADeditome: functional annotation of RNA A-to-I editing in AD

Gene summary for GSN

Gene summary

Gene information	Gene symbol	GSN
	Gene ID	2934
	Gene name	gelsolin
	Synonyms	ADF\|AGEL
	Cytomap	9q33.2
	Type of gene	protein-coding
	Description	gelsolinactin-depolymerizing factorbrevinepididymis secretory sperm binding protein
	Modification date	20200329
	UniProtAcc	P06396,
	Context	- 24486299(Trichostatin A Increases the Levels of Plasma Gelsolin and Amyloid Beta-Protein in a Transgenic Mouse Model of Alzheimer's Disease)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
GSN	GO:0030041	actin filament polymerization	3020431
GSN	GO:0051014	actin filament severing	3020431

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RNA A-to-I events for GSN

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_1434406(121273922, +), ADediting_1434407(121273995, +), ADediting_1434408(121273996, +), ADediting_1434409(121274096, +), ADediting_1434410(121274104, +), ADediting_1434411(121274105, +), ADediting_1434412(121274122, +), ADediting_1434413(121274132, +), ADediting_1434414(121274161, +), ADediting_1434415(121274177, +), ADediting_1434416(121274180, +), ADediting_1434417(121277594, +), ADediting_1434418(121277777, +), ADediting_1434419(121288001, +), ADediting_1434420(121288092, +), ADediting_1434421(121288180, +), ADediting_1434422(121290866, +), ADediting_1434423(121290874, +), ADediting_1434424(121290877, +), ADediting_1434425(121290879, +), ADediting_1434426(121290911, +), ADediting_1434427(121290912, +), ADediting_1434428(121290916, +), ADediting_1434429(121290929, +), ADediting_1434430(121290938, +), ADediting_1434431(121290951, +), ADediting_1434432(121291285, +), ADediting_1434433(121291493, +), ADediting_1434434(121291617, +), ADediting_1434435(121291625, +), ADediting_1434436(121291920, +), ADediting_1434437(121291928, +), ADediting_1434438(121291960, +), ADediting_1434439(121291971, +), ADediting_1434440(121292014, +), ADediting_1434441(121292062, +), ADediting_1434442(121292063, +), ADediting_1434443(121292086, +), ADediting_1434444(121292094, +), ADediting_1434445(121292171, +), ADediting_1434446(121292177, +), ADediting_1434447(121293487, +), ADediting_1434448(121293493, +), ADediting_1434449(121293494, +), ADediting_1434450(121293502, +), ADediting_1434451(121293534, +), ADediting_1434452(121293570, +), ADediting_1434453(121293571, +), ADediting_1434454(121293572, +), ADediting_1434455(121293573, +), ADediting_1434456(121293584, +), ADediting_1434457(121293618, +), ADediting_1434458(121293653, +), ADediting_1434459(121294081, +), ADediting_1434460(121301505, +), ADediting_1434461(121304107, +), ADediting_1434462(121304390, +), ADediting_1434463(121314901, +), ADediting_1434464(121314915, +), ADediting_1434465(121314936, +), ADediting_1434466(121314978, +), ADediting_1434467(121315022, +), ADediting_1434468(121315035, +), ADediting_1434469(121315081, +), ADediting_1434470(121315113, +), ADediting_1434471(121315508, +), ADediting_1434472(121315509, +), ADediting_1434473(121315535, +), ADediting_1434474(121315544, +), ADediting_1434475(121315554, +), ADediting_1434476(121315611, +), ADediting_1434477(121319537, +), ADediting_1434478(121319543, +), ADediting_1434479(121319558, +), ADediting_1434480(121319561, +), ADediting_1434481(121319562, +), ADediting_1434482(121319597, +), ADediting_1434483(121320389, +), ADediting_1434484(121320395, +), ADediting_1671796(121274071, +), ADediting_1671797(121274099, +), ADediting_1671798(121277657, +), ADediting_1671799(121277659, +), ADediting_1671800(121277723, +), ADediting_1671801(121277733, +), ADediting_1671802(121277745, +), ADediting_1671803(121277771, +), ADediting_1671804(121291967, +), ADediting_1671805(121292080, +),

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RNA editing positional annotations for GSN using Annovar

Protein coding RNA editing(s).

ADeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_1434406	chr9_121273922_+	intronic
ADediting_1434407	chr9_121273995_+	intronic
ADediting_1434408	chr9_121273996_+	intronic
ADediting_1434409	chr9_121274096_+	intronic
ADediting_1434410	chr9_121274104_+	intronic
ADediting_1434411	chr9_121274105_+	intronic
ADediting_1434412	chr9_121274122_+	intronic
ADediting_1434413	chr9_121274132_+	intronic
ADediting_1434414	chr9_121274161_+	intronic
ADediting_1434415	chr9_121274177_+	intronic
ADediting_1434416	chr9_121274180_+	intronic
ADediting_1434417	chr9_121277594_+	intronic
ADediting_1434418	chr9_121277777_+	intronic
ADediting_1434419	chr9_121288001_+	intronic
ADediting_1434420	chr9_121288092_+	intronic
ADediting_1434421	chr9_121288180_+	intronic
ADediting_1434422	chr9_121290866_+	intronic
ADediting_1434423	chr9_121290874_+	intronic
ADediting_1434424	chr9_121290877_+	intronic
ADediting_1434425	chr9_121290879_+	intronic
ADediting_1434426	chr9_121290911_+	intronic
ADediting_1434427	chr9_121290912_+	intronic
ADediting_1434428	chr9_121290916_+	intronic
ADediting_1434429	chr9_121290929_+	intronic
ADediting_1434430	chr9_121290938_+	intronic
ADediting_1434431	chr9_121290951_+	intronic
ADediting_1434432	chr9_121291285_+	intronic
ADediting_1434433	chr9_121291493_+	intronic
ADediting_1434434	chr9_121291617_+	intronic
ADediting_1434435	chr9_121291625_+	intronic
ADediting_1434436	chr9_121291920_+	intronic
ADediting_1434437	chr9_121291928_+	intronic
ADediting_1434438	chr9_121291960_+	intronic
ADediting_1434439	chr9_121291971_+	intronic
ADediting_1434440	chr9_121292014_+	intronic
ADediting_1434441	chr9_121292062_+	intronic
ADediting_1434442	chr9_121292063_+	intronic
ADediting_1434443	chr9_121292086_+	intronic
ADediting_1434444	chr9_121292094_+	intronic
ADediting_1434445	chr9_121292171_+	intronic
ADediting_1434446	chr9_121292177_+	intronic
ADediting_1434447	chr9_121293487_+	intronic
ADediting_1434448	chr9_121293493_+	intronic
ADediting_1434449	chr9_121293494_+	intronic
ADediting_1434450	chr9_121293502_+	intronic
ADediting_1434451	chr9_121293534_+	intronic
ADediting_1434452	chr9_121293570_+	intronic
ADediting_1434453	chr9_121293571_+	intronic
ADediting_1434454	chr9_121293572_+	intronic
ADediting_1434455	chr9_121293573_+	intronic
ADediting_1434456	chr9_121293584_+	intronic
ADediting_1434457	chr9_121293618_+	intronic
ADediting_1434458	chr9_121293653_+	intronic
ADediting_1434459	chr9_121294081_+	intronic
ADediting_1434460	chr9_121301505_+	intronic
ADediting_1434461	chr9_121304107_+	intronic
ADediting_1434462	chr9_121304390_+	intronic
ADediting_1434463	chr9_121314901_+	intronic
ADediting_1434464	chr9_121314915_+	intronic
ADediting_1434465	chr9_121314936_+	intronic
ADediting_1434466	chr9_121314978_+	intronic
ADediting_1434467	chr9_121315022_+	intronic
ADediting_1434468	chr9_121315035_+	intronic
ADediting_1434469	chr9_121315081_+	intronic
ADediting_1434470	chr9_121315113_+	intronic
ADediting_1434471	chr9_121315508_+	intronic
ADediting_1434472	chr9_121315509_+	intronic
ADediting_1434473	chr9_121315535_+	intronic
ADediting_1434474	chr9_121315544_+	intronic
ADediting_1434475	chr9_121315554_+	intronic
ADediting_1434476	chr9_121315611_+	intronic
ADediting_1434477	chr9_121319537_+	intronic
ADediting_1434478	chr9_121319543_+	intronic
ADediting_1434479	chr9_121319558_+	intronic
ADediting_1434480	chr9_121319561_+	intronic
ADediting_1434481	chr9_121319562_+	intronic
ADediting_1434482	chr9_121319597_+	intronic
ADediting_1434483	chr9_121320389_+	intronic
ADediting_1434484	chr9_121320395_+	intronic
ADediting_1671796	chr9_121274071_+	intronic
ADediting_1671797	chr9_121274099_+	intronic
ADediting_1671798	chr9_121277657_+	intronic
ADediting_1671799	chr9_121277659_+	intronic
ADediting_1671800	chr9_121277723_+	intronic
ADediting_1671801	chr9_121277733_+	intronic
ADediting_1671802	chr9_121277745_+	intronic
ADediting_1671803	chr9_121277771_+	intronic
ADediting_1671804	chr9_121291967_+	intronic
ADediting_1671805	chr9_121292080_+	intronic

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_1434419	chr9_121288001_+	SINE	Alu	Name=AluJo
ADediting_1434420	chr9_121288092_+	SINE	Alu	Name=AluJo
ADediting_1434421	chr9_121288180_+	SINE	Alu	Name=AluJo
ADediting_1434422	chr9_121290866_+	SINE	Alu	Name=AluJb
ADediting_1434423	chr9_121290874_+	SINE	Alu	Name=AluJb
ADediting_1434424	chr9_121290877_+	SINE	Alu	Name=AluJb
ADediting_1434425	chr9_121290879_+	SINE	Alu	Name=AluJb
ADediting_1434426	chr9_121290911_+	SINE	Alu	Name=AluJb
ADediting_1434427	chr9_121290912_+	SINE	Alu	Name=AluJb
ADediting_1434428	chr9_121290916_+	SINE	Alu	Name=AluJb
ADediting_1434429	chr9_121290929_+	SINE	Alu	Name=AluJb
ADediting_1434430	chr9_121290938_+	SINE	Alu	Name=AluJb
ADediting_1434431	chr9_121290951_+	SINE	Alu	Name=AluJb
ADediting_1434432	chr9_121291285_+	DNA	TcMar-Tigger	Name=MER2
ADediting_1434433	chr9_121291493_+	SINE	Alu	Name=AluSx1
ADediting_1434434	chr9_121291617_+	SINE	Alu	Name=AluSx1
ADediting_1434435	chr9_121291625_+	SINE	Alu	Name=AluSx1
ADediting_1434436	chr9_121291920_+	SINE	Alu	Name=AluJo
ADediting_1434437	chr9_121291928_+	SINE	Alu	Name=AluJo
ADediting_1434438	chr9_121291960_+	SINE	Alu	Name=AluJo
ADediting_1434439	chr9_121291971_+	SINE	Alu	Name=AluJo
ADediting_1434440	chr9_121292014_+	SINE	Alu	Name=AluJo
ADediting_1434441	chr9_121292062_+	SINE	Alu	Name=AluJo
ADediting_1434442	chr9_121292063_+	SINE	Alu	Name=AluJo
ADediting_1434443	chr9_121292086_+	SINE	Alu	Name=AluJo
ADediting_1434444	chr9_121292094_+	SINE	Alu	Name=AluJo
ADediting_1434445	chr9_121292171_+	SINE	Alu	Name=AluJo
ADediting_1434446	chr9_121292177_+	SINE	Alu	Name=AluJo
ADediting_1434447	chr9_121293487_+	SINE	Alu	Name=AluSz
ADediting_1434448	chr9_121293493_+	SINE	Alu	Name=AluSz
ADediting_1434449	chr9_121293494_+	SINE	Alu	Name=AluSz
ADediting_1434450	chr9_121293502_+	SINE	Alu	Name=AluSz
ADediting_1434451	chr9_121293534_+	SINE	Alu	Name=AluSz
ADediting_1434452	chr9_121293570_+	SINE	Alu	Name=AluSz
ADediting_1434453	chr9_121293571_+	SINE	Alu	Name=AluSz
ADediting_1434454	chr9_121293572_+	SINE	Alu	Name=AluSz
ADediting_1434455	chr9_121293573_+	SINE	Alu	Name=AluSz
ADediting_1434456	chr9_121293584_+	SINE	Alu	Name=AluSz
ADediting_1434457	chr9_121293618_+	SINE	Alu	Name=AluSz
ADediting_1434458	chr9_121293653_+	SINE	Alu	Name=AluSz
ADediting_1434460	chr9_121301505_+	SINE	Alu	Name=AluSx
ADediting_1434461	chr9_121304107_+	SINE	MIR	Name=MIR1_Amn
ADediting_1434463	chr9_121314901_+	SINE	Alu	Name=AluJb
ADediting_1434464	chr9_121314915_+	SINE	Alu	Name=AluJb
ADediting_1434465	chr9_121314936_+	SINE	Alu	Name=AluJb
ADediting_1434466	chr9_121314978_+	SINE	Alu	Name=AluJb
ADediting_1434467	chr9_121315022_+	SINE	Alu	Name=AluJb
ADediting_1434468	chr9_121315035_+	SINE	Alu	Name=AluJb
ADediting_1434469	chr9_121315081_+	SINE	Alu	Name=AluJb
ADediting_1434470	chr9_121315113_+	SINE	Alu	Name=AluJb
ADediting_1434471	chr9_121315508_+	SINE	Alu	Name=AluSq2
ADediting_1434472	chr9_121315509_+	SINE	Alu	Name=AluSq2
ADediting_1434473	chr9_121315535_+	SINE	Alu	Name=AluSq2
ADediting_1434474	chr9_121315544_+	SINE	Alu	Name=AluSq2
ADediting_1434475	chr9_121315554_+	SINE	Alu	Name=AluSq2
ADediting_1434476	chr9_121315611_+	SINE	Alu	Name=AluSq2
ADediting_1434477	chr9_121319537_+	SINE	Alu	Name=FLAM_C
ADediting_1434478	chr9_121319543_+	SINE	Alu	Name=FLAM_C
ADediting_1434479	chr9_121319558_+	SINE	Alu	Name=FLAM_C
ADediting_1434480	chr9_121319561_+	SINE	Alu	Name=FLAM_C
ADediting_1434481	chr9_121319562_+	SINE	Alu	Name=FLAM_C
ADediting_1434482	chr9_121319597_+	SINE	Alu	Name=FLAM_C
ADediting_1434483	chr9_121320389_+	SINE	Alu	Name=AluSq2
ADediting_1434484	chr9_121320395_+	SINE	Alu	Name=AluSq2
ADediting_1671804	chr9_121291967_+	SINE	Alu	Name=AluJo
ADediting_1671805	chr9_121292080_+	SINE	Alu	Name=AluJo

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RNA A-to-I editing events in the alternative splicing sites for GSN

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	ADeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ES	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ES	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ES	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ES	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ES	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME1	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME1	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME1	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME1	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME1	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME1	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME1	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME1	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME1	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME1	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME1	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME1	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME1	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME1	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73
ME2	ADediting_1434420	chr9_121288092_+	121288092:121288114	3ss	20i	AATTTTTGTATTTTTTGTAGAGA	6.53	GATTTTTGTATTTTTTGTAGAGA	6.73

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GSN

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

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Protein coding region RNA A-to-I editings for GSN

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for GSN

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GSN

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID

ENST

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in lncRNA.

ADeditom_ID

ENST

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for GSN

Correlation between ADAR gene expression and RNA editing frequency

Tissue	ADeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
TCX	ADediting_1434419	chr9_121288001_+	0.187120658102679	0.108296620076508	0.623990163715154	-0.0403461285688158	0.000110560423220364	0.310432786581747
TCX	ADediting_1434422	chr9_121290866_+	0.241837473309839	0.0961460178433025	0.0254880401049665	-0.182392159441645	1.29881224191877e-08	0.443658731032155
PG	ADediting_1434422	chr9_121290866_+	0.62674250895102	-0.0358889312650398	0.398961980705367	-0.0622061267317307	6.21971045091662e-06	0.324509510065162
STG	ADediting_1434422	chr9_121290866_+	0.0831735738757633	0.190158288430932	0.652884741125739	-0.0497882184390681	0.00253762951214612	0.325248302218643
TCX	ADediting_1434425	chr9_121290879_+	0.00298331355172869	0.240889168097216	0.495661304617628	-0.0560557102696485	1.18911903606444e-06	0.384472238644671
TCX	ADediting_1434427	chr9_121290912_+	0.0111607101696487	0.206683093412191	0.370854663404473	-0.0735825631652002	3.14792871393667e-06	0.370059604515267
STG	ADediting_1434427	chr9_121290912_+	0.000134569034133069	0.404668303181116	0.0146387199770257	0.265534705893741	0.115720834269515	0.172922802892117
TCX	ADediting_1434429	chr9_121290929_+	0.0308219453204473	0.176401975443993	0.149310514490288	-0.118312250938898	1.73993045911547e-06	0.378918974717593
PG	ADediting_1434429	chr9_121290929_+	0.181754781009029	-0.0983396263449899	0.664610658436508	-0.0319974539806402	3.35046849428687e-06	0.333266171039943
TCX	ADediting_1434430	chr9_121290938_+	0.0579483563661681	0.155173970742524	0.183402151949026	-0.109211228348367	0.000160169095714293	0.303445877051217
FP	ADediting_1434430	chr9_121290938_+	0.276205863425747	0.0820555548530607	0.900610971130393	-0.00942707787435605	1.55397436459935e-06	0.351034872770965
TCX	ADediting_1434432	chr9_121291285_+	0.0010392453169727	0.265192082800962	0.93433350306103	0.00678410707158327	3.6300269689914e-07	0.401158723974661
TCX	ADediting_1434435	chr9_121291625_+	0.13934250464259	0.121266661422761	0.125373428167361	-0.125691258406061	7.6028434931246e-05	0.317318923475267
TCX	ADediting_1434437	chr9_121291928_+	0.0133793966416064	0.201569815869942	0.510326929783357	-0.0541659570905541	5.67620965797535e-05	0.322579191961216
FP	ADediting_1434437	chr9_121291928_+	0.73484798324916	0.0255613581500926	0.328026168651369	-0.0737311131543486	8.12041842828868e-07	0.359781909445014
TCX	ADediting_1434439	chr9_121291971_+	0.00708905212505037	0.219008912372289	0.791938556040348	-0.021717839757597	1.65298316790219e-05	0.34378134098126
FP	ADediting_1434443	chr9_121292086_+	0.769139775895115	0.0221521448056192	0.54858425315918	0.0452589395937534	5.53976008932416e-10	0.443693310894934
FP	ADediting_1434444	chr9_121292094_+	0.903939412029427	-0.00910982353630384	0.650023377272374	-0.034239733048703	7.80352322186942e-07	0.360309995776186
TCX	ADediting_1434448	chr9_121293493_+	0.000848439366901792	0.269615717004125	0.689642256167956	-0.0328721996164789	4.24928341533564e-06	0.365475021172013
TCX	ADediting_1434449	chr9_121293494_+	0.00160654753219036	0.255431465496736	0.96118047612824	-0.00400758356138295	7.52617919244037e-05	0.31750298868614
TCX	ADediting_1434452	chr9_121293570_+	0.000539557240325207	0.279227800195937	0.400655069165908	-0.0691187011948893	3.21140608986506e-10	0.484908046564184
TCX	ADediting_1434455	chr9_121293573_+	0.643147032284546	0.0381337923303589	0.137005782233908	-0.121982386490405	6.22295509725995e-05	0.320934359855411
TCX	ADediting_1434458	chr9_121293653_+	0.060338381093704	0.153736657256388	0.118632326433491	-0.127963621702224	3.23311447927434e-05	0.33244538863626

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	2.39117512471877e-07	0.288321326095066	0.00196194487835946	0.175183174137646	1.56027810693712e-45	0.692184840319265
AC	6.14125887049242e-30	0.637686568856634	7.76709087166863e-15	0.465311783093634	8.99789538941723e-38	0.69757579225732
PCC	0.0231358860531145	0.164297187131215	0.253746063848086	0.0829836135091597	5.15030938741862e-13	0.491588836436745
CER	0.000626585948025832	0.27609060849223	0.00285709171554325	0.241932579199968	4.20875007420395e-22	0.684956791680398
TCX	0.00155833376857151	0.256126353424718	0.00544966283217957	-0.225868355137238	2.15406762850074e-22	0.688414215426783
FP	4.9791486144074e-06	0.334649709972357	0.0132347426225895	0.185381837273153	6.04612770869146e-22	0.640578169383752
IFG	0.428213002350314	0.165839196424443	0.614953006660038	0.105733593571	0.0151999041536651	0.479873451195715
PG	0.0190598289465779	-0.171775020315521	1.76554402712729e-05	-0.309093753123673	3.85577994002787e-19	0.59424538153387
STG	0.0188486448614062	0.25579750523482	0.339049774669548	-0.105603294944692	9.24294871755087e-08	0.543392426182925

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Relation with AD stages for GSN

Correlation between AD stages and RNA editing frequency

Tissue	ADeditomID	position	P-val	Coeff.
TCX	ADediting_1434435	chr9_121291625_+	0.00102141089436294	0.314613472864887
TCX	ADediting_1434447	chr9_121293487_+	0.00016514184444965	0.357938918834582
TCX	ADediting_1434449	chr9_121293494_+	0.000822760617581057	0.320099881930038
TCX	ADediting_1434452	chr9_121293570_+	2.11474204457518e-05	0.400365040268528
IFG	ADediting_1434430	chr9_121290938_+	0.0423795586445896	0.40894316526528
IFG	ADediting_1434437	chr9_121291928_+	0.0444242522908403	0.405321131184881
IFG	ADediting_1434452	chr9_121293570_+	0.0121433827660198	0.493672856024155
STG	ADediting_1434454	chr9_121293572_+	0.00424929948790182	0.308907159785028

Correlation between AD stages and this gene's expression

Tissue	P-val	Coeff.
CER	5.81030204196467e-07	0.459096844140988
TCX	1.36778591993045e-09	0.546439859027381

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RelatedDrugs for GSN

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
GSN	P06396	DB01593	Zinc	Gelsolin	small molecule	approved\|investigational
GSN	P06396	DB14487	Zinc acetate	Gelsolin	small molecule	approved\|investigational
GSN	P06396	DB14533	Zinc chloride	Gelsolin	small molecule	approved\|investigational

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RelatedDiseases for GSN

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
GSN	C1855670	Abnormality of the cornea	3	GENOMICS_ENGLAND
GSN	C1622345	Meretoja syndrome	2	CTD_human;UNIPROT
GSN	C1628319	Lattice corneal dystrophy Type II	2	CTD_human;UNIPROT
GSN	C2751493	Cerebral Amyloid Angiopathy, Gsn-Related	2	CTD_human;UNIPROT
GSN	C0001787	Osteoporosis, Age-Related	1	CTD_human
GSN	C0019193	Hepatitis, Toxic	1	CTD_human
GSN	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
GSN	C0025500	Mesothelioma	1	CTD_human
GSN	C0029456	Osteoporosis	1	CTD_human
GSN	C0029459	Osteoporosis, Senile	1	CTD_human
GSN	C0030524	Paratuberculosis	1	CTD_human
GSN	C0036341	Schizophrenia	1	PSYGENET
GSN	C0043094	Weight Gain	1	CTD_human
GSN	C0751406	Post-Traumatic Osteoporosis	1	CTD_human
GSN	C0860207	Drug-Induced Liver Disease	1	CTD_human
GSN	C0948089	Acute Coronary Syndrome	1	CTD_human
GSN	C1262760	Hepatitis, Drug-Induced	1	CTD_human
GSN	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
GSN	C3889979	Periodic Fever Syndrome	1	GENOMICS_ENGLAND
GSN	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
GSN	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human

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Gene summary for GSN

RNA A-to-I events for GSN

RNA editing positional annotations for GSN using Annovar

RNA A-to-I editing events in the alternative splicing sites for GSN

Differntial gene expression between RNA A-to-I edited versus non-edited samples for GSN

Protein coding region RNA A-to-I editings for GSN

The effects of the RNA editing to the miRNA binding sites for GSN

The effects of the RNA editing to the stability of the RNA structures for GSN

Relation with ADAR for GSN

Relation with AD stages for GSN

RelatedDrugs for GSN

RelatedDiseases for GSN

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene