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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for GRM4 |
 Gene summary |
| Gene information | Gene symbol | GRM4 | Gene ID | 2914 |
| Gene name | glutamate metabotropic receptor 4 | |
| Synonyms | GPRC1D|MGLUR4|mGlu4 | |
| Cytomap | 6p21.31 | |
| Type of gene | protein-coding | |
| Description | metabotropic glutamate receptor 4glutamate receptor, metabotropic 4 | |
| Modification date | 20200313 | |
| UniProtAcc | Q14833, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| GRM4 | GO:0000187 | activation of MAPK activity | 15102938 |
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RNA A-to-I events for GRM4 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1254693(34046832, -), ADediting_1254694(34053980, -), ADediting_1254695(34110211, -), ADediting_1254696(34110212, -), ADediting_1254697(34113244, -), ADediting_1254698(34113276, -), ADediting_1254699(34113316, -), ADediting_1254700(34119139, -), ADediting_1254701(34119170, -), ADediting_1254702(34119233, -), ADediting_1254703(34120789, -), ADediting_1254704(34120794, -), ADediting_1254705(34120795, -), ADediting_1254706(34120799, -), ADediting_1254707(34120861, -), ADediting_1254708(34120866, -), ADediting_1254709(34120867, -), ADediting_1254710(34125098, -), ADediting_1254711(34125138, -), ADediting_1254712(34128516, -), ADediting_1254713(34133126, -), ADediting_1583566(34042166, -), ADediting_1583567(34045347, -), ADediting_1583568(34053703, -), ADediting_1583569(34062212, -), ADediting_1583570(34062247, -), ADediting_1583571(34062318, -), ADediting_1583572(34062356, -), ADediting_1583573(34062368, -), ADediting_1583574(34062391, -), ADediting_1583575(34062954, -), ADediting_1583576(34075091, -), ADediting_1583577(34080457, -), ADediting_1583578(34086919, -), ADediting_1583579(34087001, -), ADediting_1583580(34087003, -), ADediting_1583581(34087039, -), ADediting_1583582(34087073, -), ADediting_1583583(34087162, -), ADediting_1583584(34087174, -), ADediting_1583585(34087236, -), ADediting_1583586(34087253, -), ADediting_1583587(34087262, -), ADediting_1583588(34087271, -), ADediting_1583589(34087287, -), ADediting_1583590(34088169, -), ADediting_1583591(34088219, -), ADediting_1583592(34089028, -), ADediting_1583593(34106212, -), ADediting_1583594(34106218, -), ADediting_1583595(34106315, -), ADediting_1583596(34106363, -), ADediting_1583597(34113212, -), ADediting_1583598(34113284, -), ADediting_1583599(34119151, -), ADediting_1583600(34119213, -), ADediting_1583601(34119216, -), ADediting_1583602(34119239, -), ADediting_1583603(34120828, -), ADediting_1583604(34120862, -), ADediting_1583605(34128526, -), |
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RNA editing positional annotations for GRM4 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_1254713 | chr6_34133126_- | nonsynonymous SNV | ENST00000538487.6 | c.A371G | p.Q124R | 1.0 | 0.151 | 0.44 |
| ADediting_1254713 | chr6_34133126_- | nonsynonymous SNV | ENST00000374181.8 | c.A371G | p.Q124R | 1.0 | 0.151 | 0.44 |
| ADediting_1254713 | chr6_34133126_- | nonsynonymous SNV | ENST00000609278.1 | c.A371G | p.Q124R | 1.0 | 0.151 | 0.44 |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1254693 | chr6_34046832_- | intronic |
| ADediting_1254694 | chr6_34053980_- | intronic |
| ADediting_1254695 | chr6_34110211_- | intronic |
| ADediting_1254696 | chr6_34110212_- | intronic |
| ADediting_1254697 | chr6_34113244_- | intronic |
| ADediting_1254698 | chr6_34113276_- | intronic |
| ADediting_1254699 | chr6_34113316_- | intronic |
| ADediting_1254700 | chr6_34119139_- | intronic |
| ADediting_1254701 | chr6_34119170_- | intronic |
| ADediting_1254702 | chr6_34119233_- | intronic |
| ADediting_1254703 | chr6_34120789_- | intronic |
| ADediting_1254704 | chr6_34120794_- | intronic |
| ADediting_1254705 | chr6_34120795_- | intronic |
| ADediting_1254706 | chr6_34120799_- | intronic |
| ADediting_1254707 | chr6_34120861_- | intronic |
| ADediting_1254708 | chr6_34120866_- | intronic |
| ADediting_1254709 | chr6_34120867_- | intronic |
| ADediting_1254710 | chr6_34125098_- | intronic |
| ADediting_1254711 | chr6_34125138_- | intronic |
| ADediting_1254712 | chr6_34128516_- | intronic |
| ADediting_1254713 | chr6_34133126_- | exonic |
| ADediting_1583566 | chr6_34042166_- | intronic |
| ADediting_1583567 | chr6_34045347_- | intronic |
| ADediting_1583568 | chr6_34053703_- | intronic |
| ADediting_1583569 | chr6_34062212_- | intronic |
| ADediting_1583570 | chr6_34062247_- | intronic |
| ADediting_1583571 | chr6_34062318_- | intronic |
| ADediting_1583572 | chr6_34062356_- | intronic |
| ADediting_1583573 | chr6_34062368_- | intronic |
| ADediting_1583574 | chr6_34062391_- | intronic |
| ADediting_1583575 | chr6_34062954_- | intronic |
| ADediting_1583576 | chr6_34075091_- | intronic |
| ADediting_1583577 | chr6_34080457_- | intronic |
| ADediting_1583578 | chr6_34086919_- | intronic |
| ADediting_1583579 | chr6_34087001_- | intronic |
| ADediting_1583580 | chr6_34087003_- | intronic |
| ADediting_1583581 | chr6_34087039_- | intronic |
| ADediting_1583582 | chr6_34087073_- | intronic |
| ADediting_1583583 | chr6_34087162_- | intronic |
| ADediting_1583584 | chr6_34087174_- | intronic |
| ADediting_1583585 | chr6_34087236_- | intronic |
| ADediting_1583586 | chr6_34087253_- | intronic |
| ADediting_1583587 | chr6_34087262_- | intronic |
| ADediting_1583588 | chr6_34087271_- | intronic |
| ADediting_1583589 | chr6_34087287_- | intronic |
| ADediting_1583590 | chr6_34088169_- | intronic |
| ADediting_1583591 | chr6_34088219_- | intronic |
| ADediting_1583592 | chr6_34089028_- | intronic |
| ADediting_1583593 | chr6_34106212_- | intronic |
| ADediting_1583594 | chr6_34106218_- | intronic |
| ADediting_1583595 | chr6_34106315_- | intronic |
| ADediting_1583596 | chr6_34106363_- | intronic |
| ADediting_1583597 | chr6_34113212_- | intronic |
| ADediting_1583598 | chr6_34113284_- | intronic |
| ADediting_1583599 | chr6_34119151_- | intronic |
| ADediting_1583600 | chr6_34119213_- | intronic |
| ADediting_1583601 | chr6_34119216_- | intronic |
| ADediting_1583602 | chr6_34119239_- | intronic |
| ADediting_1583603 | chr6_34120828_- | intronic |
| ADediting_1583604 | chr6_34120862_- | intronic |
| ADediting_1583605 | chr6_34128526_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1254694 | chr6_34053980_- | DNA | hAT-Charlie | Name=MER5B |
| ADediting_1254695 | chr6_34110211_- | SINE | Alu | Name=AluJo |
| ADediting_1254696 | chr6_34110212_- | SINE | Alu | Name=AluJo |
| ADediting_1254697 | chr6_34113244_- | SINE | Alu | Name=AluJr |
| ADediting_1254698 | chr6_34113276_- | SINE | Alu | Name=AluJr |
| ADediting_1254699 | chr6_34113316_- | SINE | Alu | Name=AluJr |
| ADediting_1254700 | chr6_34119139_- | SINE | Alu | Name=AluSx1 |
| ADediting_1254701 | chr6_34119170_- | SINE | Alu | Name=AluSx1 |
| ADediting_1254702 | chr6_34119233_- | SINE | Alu | Name=AluSx1 |
| ADediting_1254703 | chr6_34120789_- | SINE | Alu | Name=AluSc8 |
| ADediting_1254704 | chr6_34120794_- | SINE | Alu | Name=AluSc8 |
| ADediting_1254705 | chr6_34120795_- | SINE | Alu | Name=AluSc8 |
| ADediting_1254706 | chr6_34120799_- | SINE | Alu | Name=AluSc8 |
| ADediting_1254707 | chr6_34120861_- | SINE | Alu | Name=AluSc8 |
| ADediting_1254708 | chr6_34120866_- | SINE | Alu | Name=AluSc8 |
| ADediting_1254709 | chr6_34120867_- | SINE | Alu | Name=AluSc8 |
| ADediting_1254710 | chr6_34125098_- | SINE | Alu | Name=AluY |
| ADediting_1254711 | chr6_34125138_- | SINE | Alu | Name=AluY |
| ADediting_1254712 | chr6_34128516_- | SINE | Alu | Name=AluSq2 |
| ADediting_1583566 | chr6_34042166_- | SINE | Alu | Name=AluSx1 |
| ADediting_1583568 | chr6_34053703_- | DNA | hAT-Charlie | Name=MER5B |
| ADediting_1583569 | chr6_34062212_- | SINE | MIR | Name=MIRc |
| ADediting_1583570 | chr6_34062247_- | SINE | MIR | Name=MIRc |
| ADediting_1583571 | chr6_34062318_- | SINE | MIR | Name=MIR |
| ADediting_1583572 | chr6_34062356_- | SINE | MIR | Name=MIR |
| ADediting_1583573 | chr6_34062368_- | SINE | MIR | Name=MIR |
| ADediting_1583574 | chr6_34062391_- | SINE | MIR | Name=MIR |
| ADediting_1583575 | chr6_34062954_- | SINE | MIR | Name=MIR3 |
| ADediting_1583577 | chr6_34080457_- | LINE | L2 | Name=L2a |
| ADediting_1583578 | chr6_34086919_- | SINE | Alu | Name=AluJb |
| ADediting_1583579 | chr6_34087001_- | SINE | Alu | Name=AluJb |
| ADediting_1583580 | chr6_34087003_- | SINE | Alu | Name=AluJb |
| ADediting_1583581 | chr6_34087039_- | SINE | Alu | Name=AluJb |
| ADediting_1583582 | chr6_34087073_- | SINE | Alu | Name=AluJb |
| ADediting_1583583 | chr6_34087162_- | SINE | Alu | Name=AluSx |
| ADediting_1583584 | chr6_34087174_- | SINE | Alu | Name=AluSx |
| ADediting_1583585 | chr6_34087236_- | SINE | Alu | Name=AluSx |
| ADediting_1583586 | chr6_34087253_- | SINE | Alu | Name=AluSx |
| ADediting_1583587 | chr6_34087262_- | SINE | Alu | Name=AluSx |
| ADediting_1583588 | chr6_34087271_- | SINE | Alu | Name=AluSx |
| ADediting_1583589 | chr6_34087287_- | SINE | Alu | Name=AluSx |
| ADediting_1583590 | chr6_34088169_- | SINE | Alu | Name=AluSg |
| ADediting_1583591 | chr6_34088219_- | SINE | Alu | Name=AluSg |
| ADediting_1583592 | chr6_34089028_- | SINE | MIR | Name=MIRb |
| ADediting_1583593 | chr6_34106212_- | SINE | Alu | Name=AluSx1 |
| ADediting_1583594 | chr6_34106218_- | SINE | Alu | Name=AluSx1 |
| ADediting_1583595 | chr6_34106315_- | SINE | Alu | Name=AluSx1 |
| ADediting_1583596 | chr6_34106363_- | SINE | Alu | Name=AluSx1 |
| ADediting_1583597 | chr6_34113212_- | SINE | Alu | Name=AluJr |
| ADediting_1583598 | chr6_34113284_- | SINE | Alu | Name=AluJr |
| ADediting_1583599 | chr6_34119151_- | SINE | Alu | Name=AluSx1 |
| ADediting_1583600 | chr6_34119213_- | SINE | Alu | Name=AluSx1 |
| ADediting_1583601 | chr6_34119216_- | SINE | Alu | Name=AluSx1 |
| ADediting_1583602 | chr6_34119239_- | SINE | Alu | Name=AluSx1 |
| ADediting_1583603 | chr6_34120828_- | SINE | Alu | Name=AluSc8 |
| ADediting_1583604 | chr6_34120862_- | SINE | Alu | Name=AluSc8 |
| ADediting_1583605 | chr6_34128526_- | SINE | Alu | Name=AluSq2 |
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RNA A-to-I editing events in the alternative splicing sites for GRM4 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GRM4 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for GRM4 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for GRM4 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000124493.13 | ENST00000374181.8 | GRM4-202 | hsa-miR-589-3p | chr6 | 34020399 | 34020406 | 8mer-1a | 34020399 | 34020422 | 151 | -18.05 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000124493.13 | ENST00000374181.8 | GRM4-202 | hsa-miR-589-3p | chr6 | 34020435 | 34020441 | 7mer-m8 | 34020434 | 34020456 | 156 | -26.5 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000124493.13 | ENST00000374181.8 | GRM4-202 | hsa-miR-589-3p | chr6 | 34021584 | 34021590 | 7mer-m8 | 34021583 | 34021606 | 150 | -18.94 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000124493.13 | ENST00000535756.5 | GRM4-204 | hsa-miR-589-3p | chr6 | 34020399 | 34020406 | 8mer-1a | 34020399 | 34020422 | 151 | -18.05 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000124493.13 | ENST00000535756.5 | GRM4-204 | hsa-miR-589-3p | chr6 | 34020435 | 34020441 | 7mer-m8 | 34020434 | 34020456 | 156 | -26.5 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000124493.13 | ENST00000535756.5 | GRM4-204 | hsa-miR-589-3p | chr6 | 34021584 | 34021590 | 7mer-m8 | 34021583 | 34021606 | 150 | -18.94 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000124493.13 | ENST00000374181.8 | GRM4-202 | hsa-miR-151a-3p | chr6 | 34020347 | 34020353 | 7mer-m8 | 34020346 | 34020365 | 146 | -22.91 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000124493.13 | ENST00000535756.5 | GRM4-204 | hsa-miR-151a-3p | chr6 | 34020347 | 34020353 | 7mer-m8 | 34020346 | 34020365 | 146 | -22.91 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000124493.13 | ENST00000374181.8 | GRM4-202 | hsa-miR-4477b | chr6 | 34019631 | 34019637 | 7mer-m8 | 34019630 | 34019651 | 140 | -12.85 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000124493.13 | ENST00000374181.8 | GRM4-202 | hsa-miR-4477b | chr6 | 34019796 | 34019802 | 7mer-m8 | 34019795 | 34019816 | 140 | -11.42 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000124493.13 | ENST00000535756.5 | GRM4-204 | hsa-miR-4477b | chr6 | 34019631 | 34019637 | 7mer-m8 | 34019630 | 34019651 | 140 | -12.85 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000124493.13 | ENST00000535756.5 | GRM4-204 | hsa-miR-4477b | chr6 | 34019796 | 34019802 | 7mer-m8 | 34019795 | 34019816 | 140 | -11.42 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000124493.13 | ENST00000374177.7 | GRM4-201 | hsa-miR-4775 | chr6 | 34022158 | 34022165 | 8mer-1a | 34022158 | 34022178 | 157 | -10.15 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000124493.13 | ENST00000374181.8 | GRM4-202 | hsa-miR-4775 | chr6 | 34022158 | 34022165 | 8mer-1a | 34022158 | 34022178 | 157 | -10.15 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000124493.13 | ENST00000535756.5 | GRM4-204 | hsa-miR-4775 | chr6 | 34022158 | 34022165 | 8mer-1a | 34022158 | 34022178 | 157 | -10.15 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000124493.13 | ENST00000538487.6 | GRM4-205 | hsa-miR-4775 | chr6 | 34022158 | 34022165 | 8mer-1a | 34022158 | 34022178 | 157 | -10.15 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_107020 | chr1_37500952_- | ENSG00000124493.13 | ENST00000374181.8 | GRM4-202 | hsa-miR-5581-3p | chr6 | 34021674 | 34021680 | 7mer-m8 | 34021673 | 34021694 | 146 | -18.98 |
| ADediting_107020 | chr1_37500952_- | ENSG00000124493.13 | ENST00000535756.5 | GRM4-204 | hsa-miR-5581-3p | chr6 | 34021674 | 34021680 | 7mer-m8 | 34021673 | 34021694 | 146 | -18.98 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000124493.13 | ENST00000374181.8 | GRM4-202 | hsa-miR-589-3p | chr6 | 34019208 | 34019215 | 8mer-1a | 34019208 | 34019232 | 143 | -20.27 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000124493.13 | ENST00000535756.5 | GRM4-204 | hsa-miR-589-3p | chr6 | 34019208 | 34019215 | 8mer-1a | 34019208 | 34019232 | 143 | -20.27 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000124493.13 | ENST00000374181.8 | GRM4-202 | hsa-miR-641 | chr6 | 34019194 | 34019201 | 8mer-1a | 34019194 | 34019220 | 153 | -19.24 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000124493.13 | ENST00000374181.8 | GRM4-202 | hsa-miR-641 | chr6 | 34020819 | 34020825 | 7mer-m8 | 34020818 | 34020844 | 152 | -12.22 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000124493.13 | ENST00000535756.5 | GRM4-204 | hsa-miR-641 | chr6 | 34019194 | 34019201 | 8mer-1a | 34019194 | 34019220 | 153 | -19.24 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000124493.13 | ENST00000535756.5 | GRM4-204 | hsa-miR-641 | chr6 | 34020819 | 34020825 | 7mer-m8 | 34020818 | 34020844 | 152 | -12.22 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000124493.13 | ENST00000374181.8 | GRM4-202 | hsa-miR-641 | chr6 | 34019194 | 34019201 | 8mer-1a | 34019194 | 34019220 | 153 | -19.24 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000124493.13 | ENST00000374181.8 | GRM4-202 | hsa-miR-641 | chr6 | 34020819 | 34020825 | 7mer-m8 | 34020818 | 34020844 | 152 | -12.22 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000124493.13 | ENST00000535756.5 | GRM4-204 | hsa-miR-641 | chr6 | 34019194 | 34019201 | 8mer-1a | 34019194 | 34019220 | 153 | -19.24 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000124493.13 | ENST00000535756.5 | GRM4-204 | hsa-miR-641 | chr6 | 34020819 | 34020825 | 7mer-m8 | 34020818 | 34020844 | 152 | -12.22 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000124493.13 | ENST00000374181.8 | GRM4-202 | hsa-miR-5682 | chr6 | 34021366 | 34021373 | 8mer-1a | 34021366 | 34021389 | 143 | -17.25 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000124493.13 | ENST00000535756.5 | GRM4-204 | hsa-miR-5682 | chr6 | 34021366 | 34021373 | 8mer-1a | 34021366 | 34021389 | 143 | -17.25 |
| ADediting_496066 | chr15_66496985_- | ENSG00000124493.13 | ENST00000374181.8 | GRM4-202 | hsa-miR-4512 | chr6 | 34018699 | 34018705 | 7mer-m8 | 34018698 | 34018719 | 140 | -19.27 |
| ADediting_496066 | chr15_66496985_- | ENSG00000124493.13 | ENST00000374181.8 | GRM4-202 | hsa-miR-4512 | chr6 | 34019159 | 34019165 | 7mer-m8 | 34019158 | 34019179 | 142 | -18.45 |
| ADediting_496066 | chr15_66496985_- | ENSG00000124493.13 | ENST00000374181.8 | GRM4-202 | hsa-miR-4512 | chr6 | 34020006 | 34020013 | 8mer-1a | 34020006 | 34020027 | 141 | -17.22 |
| ADediting_496066 | chr15_66496985_- | ENSG00000124493.13 | ENST00000535756.5 | GRM4-204 | hsa-miR-4512 | chr6 | 34018699 | 34018705 | 7mer-m8 | 34018698 | 34018719 | 140 | -19.27 |
| ADediting_496066 | chr15_66496985_- | ENSG00000124493.13 | ENST00000535756.5 | GRM4-204 | hsa-miR-4512 | chr6 | 34019159 | 34019165 | 7mer-m8 | 34019158 | 34019179 | 142 | -18.45 |
| ADediting_496066 | chr15_66496985_- | ENSG00000124493.13 | ENST00000535756.5 | GRM4-204 | hsa-miR-4512 | chr6 | 34020006 | 34020013 | 8mer-1a | 34020006 | 34020027 | 141 | -17.22 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for GRM4 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000374181.8 | protein_coding |  |  |
| ENST00000538487.6 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1254713 | ENST00000374181.8 | chr6_34133126_- | 872 | -3149.40 | -3143.20 | -3149.40 |
| ADediting_1254713 | ENST00000538487.6 | chr6_34133126_- | 815 | -1683.70 | -1677.50 | -1683.70 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for GRM4 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1254693 | chr6_34046832_- | 0.0899308519507859 | 0.138948333159446 | 0.00010158913559001 | 0.312003804586421 | 0.0150690855423958 | 0.198152570744138 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 4.98238729672478e-30 | 0.586449922243465 | 3.02564499435299e-59 | 0.75856961877476 | 0.0786914350621947 | 0.100019904122873 |
| AC | 2.06250668041709e-26 | 0.605599559513142 | 1.19117808266995e-39 | 0.710027246617315 | 0.778728710231866 | -0.0178585722031012 |
| PCC | 1.12469986812226e-06 | 0.343732640257377 | 8.03932840091991e-07 | 0.348096473301872 | 0.0750836595124742 | 0.129100815065999 |
| CER | 7.71230103726712e-08 | 0.421656321605793 | 1.16208478159747e-13 | 0.558175172535207 | 0.439168407399153 | 0.0636322978245413 |
| TCX | 0.622211117097928 | -0.0405530306413144 | 1.13612171879607e-07 | 0.41665683109888 | 0.180206906597586 | -0.110008060229109 |
| FP | 3.73538646451215e-19 | 0.605036589303649 | 5.82966318554381e-21 | 0.628558144512226 | 1.73868082186161e-05 | 0.315941728221142 |
| IFG | 0.0214482330176108 | 0.457592045170227 | 0.00453015359051235 | 0.54844797381037 | 0.11385597611495 | 0.324207395540427 |
| PG | 0.0317909421246024 | 0.157505654084269 | 4.06623571620914e-07 | 0.361258655084918 | 0.572605484611294 | -0.0416332213014725 |
| STG | 3.10773277448288e-07 | 0.524130558965965 | 3.94427580590624e-11 | 0.643830728872381 | 0.747219398214015 | 0.0356902536741789 |
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Relation with AD stages for GRM4 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_1254695 | chr6_34110211_- | 2.08966165790315e-06 | 0.438324482093908 |
| CER | ADediting_1254696 | chr6_34110212_- | 0.000118102735772132 | 0.362033310479347 |
| CER | ADediting_1254698 | chr6_34113276_- | 0.000447206837124579 | 0.332028852487335 |
| CER | ADediting_1254699 | chr6_34113316_- | 6.80798119882093e-05 | 0.37362652132423 |
| CER | ADediting_1254700 | chr6_34119139_- | 0.00123056788118892 | 0.306997427628253 |
| CER | ADediting_1254703 | chr6_34120789_- | 9.00041356818762e-05 | 0.367806268152121 |
| CER | ADediting_1254704 | chr6_34120794_- | 6.4970896456284e-05 | 0.374590266601766 |
| CER | ADediting_1254705 | chr6_34120795_- | 0.000704636316182544 | 0.321049588689665 |
| CER | ADediting_1254706 | chr6_34120799_- | 0.000162827133055396 | 0.355065522126573 |
| CER | ADediting_1254707 | chr6_34120861_- | 3.8037603447701e-05 | 0.385418524504255 |
| CER | ADediting_1254708 | chr6_34120866_- | 0.000290555523965136 | 0.342078950571001 |
| CER | ADediting_1583572 | chr6_34062356_- | 3.14206792898372e-05 | 0.389193604289799 |
| CER | ADediting_1583576 | chr6_34075091_- | 4.62868306599837e-05 | 0.381492601804403 |
| CER | ADediting_1583581 | chr6_34087039_- | 0.00126371468970941 | 0.306310187399852 |
| CER | ADediting_1583598 | chr6_34113284_- | 0.000189057164491894 | 0.351769320607669 |
| CER | ADediting_1583599 | chr6_34119151_- | 0.000552339360223005 | 0.32698100755301 |
| CER | ADediting_1583600 | chr6_34119213_- | 7.65620055682679e-05 | 0.371192013300856 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for GRM4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| GRM4 | Q14833 | DB00142 | Glutamic Acid | Metabotropic glutamate receptor 4 | small molecule | approved|nutraceutical |
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RelatedDiseases for GRM4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| GRM4 | C0036341 | Schizophrenia | 3 | PSYGENET |
| GRM4 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| GRM4 | C0014556 | Epilepsy, Temporal Lobe | 1 | CTD_human |
| GRM4 | C0014558 | Uncinate Epilepsy | 1 | CTD_human |
| GRM4 | C0027746 | Nerve Degeneration | 1 | CTD_human |
| GRM4 | C0029463 | Osteosarcoma | 1 | CTD_human |
| GRM4 | C0393672 | Epilepsy, Benign Psychomotor, Childhood | 1 | CTD_human |
| GRM4 | C0393682 | Epilepsy, Lateral Temporal | 1 | CTD_human |
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