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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for N6AMT1

check button Gene summary
Gene informationGene symbol

N6AMT1

Gene ID

29104

Gene nameN-6 adenine-specific DNA methyltransferase 1
SynonymsC21orf127|HEMK2|KMT9|MTQ2|N6AMT|PRED28|PrmC|m.HsaHemK2P
Cytomap

21q21.3

Type of geneprotein-coding
Descriptionmethyltransferase N6AMT1HemK methyltransferase family member 2N-6 adenine-specific DNA methyltransferase 1 (putative)N6-DNA-methyltransferasemethylarsonite methyltransferase N6AMT1protein N(5)-glutamine methyltransferase
Modification date20200313
UniProtAcc

Q9Y5N5,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
N6AMT1

GO:0009404

toxin metabolic process

25997655

N6AMT1

GO:0018364

peptidyl-glutamine methylation

18539146

N6AMT1

GO:0018872

arsonoacetate metabolic process

25997655

N6AMT1

GO:0030307

positive regulation of cell growth

18539146

N6AMT1

GO:0032259

methylation

25997655

N6AMT1

GO:0032775

DNA methylation on adenine

30017583


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RNA A-to-I events for N6AMT1

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_954418(28873461, -), ADediting_954419(28873481, -), ADediting_954420(28873493, -), ADediting_954421(28873516, -), ADediting_954422(28873550, -), ADediting_954423(28873593, -), ADediting_954424(28873599, -), ADediting_954425(28873600, -), ADediting_954426(28873616, -), ADediting_954427(28873622, -), ADediting_954428(28873629, -), ADediting_954429(28873634, -), ADediting_954430(28873648, -), ADediting_954431(28873663, -), ADediting_954432(28873668, -), ADediting_954433(28873669, -), ADediting_954434(28873792, -), ADediting_954435(28873793, -), ADediting_954436(28873910, -), ADediting_1568373(28873475, -), ADediting_1568374(28873537, -), ADediting_1568375(28873541, -),

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RNA editing positional annotations for N6AMT1 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_954418chr21_28873461_-UTR3
ADediting_954419chr21_28873481_-UTR3
ADediting_954420chr21_28873493_-UTR3
ADediting_954421chr21_28873516_-UTR3
ADediting_954422chr21_28873550_-UTR3
ADediting_954423chr21_28873593_-UTR3
ADediting_954424chr21_28873599_-UTR3
ADediting_954425chr21_28873600_-UTR3
ADediting_954426chr21_28873616_-UTR3
ADediting_954427chr21_28873622_-UTR3
ADediting_954428chr21_28873629_-UTR3
ADediting_954429chr21_28873634_-UTR3
ADediting_954430chr21_28873648_-UTR3
ADediting_954431chr21_28873663_-UTR3
ADediting_954432chr21_28873668_-UTR3
ADediting_954433chr21_28873669_-UTR3
ADediting_954434chr21_28873792_-UTR3
ADediting_954435chr21_28873793_-UTR3
ADediting_954436chr21_28873910_-UTR3
ADediting_1568373chr21_28873475_-UTR3
ADediting_1568374chr21_28873537_-UTR3
ADediting_1568375chr21_28873541_-UTR3

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_954418chr21_28873461_-LTRERVLName=ERVL-B4-int
ADediting_954419chr21_28873481_-LTRERVLName=ERVL-B4-int
ADediting_954420chr21_28873493_-LTRERVLName=ERVL-B4-int
ADediting_954421chr21_28873516_-LTRERVLName=ERVL-B4-int
ADediting_954422chr21_28873550_-LTRERVLName=ERVL-B4-int
ADediting_954423chr21_28873593_-LTRERVLName=ERVL-B4-int
ADediting_954424chr21_28873599_-LTRERVLName=ERVL-B4-int
ADediting_954425chr21_28873600_-LTRERVLName=ERVL-B4-int
ADediting_954426chr21_28873616_-LTRERVLName=ERVL-B4-int
ADediting_954427chr21_28873622_-LTRERVLName=ERVL-B4-int
ADediting_954428chr21_28873629_-LTRERVLName=ERVL-B4-int
ADediting_954429chr21_28873634_-LTRERVLName=ERVL-B4-int
ADediting_954430chr21_28873648_-LTRERVLName=ERVL-B4-int
ADediting_954431chr21_28873663_-LTRERVLName=ERVL-B4-int
ADediting_954432chr21_28873668_-LTRERVLName=ERVL-B4-int
ADediting_954433chr21_28873669_-LTRERVLName=ERVL-B4-int
ADediting_954434chr21_28873792_-LTRERVLName=ERVL-B4-int
ADediting_954435chr21_28873793_-LTRERVLName=ERVL-B4-int
ADediting_954436chr21_28873910_-LTRERVLName=ERVL-B4-int
ADediting_1568373chr21_28873475_-LTRERVLName=ERVL-B4-int
ADediting_1568374chr21_28873537_-LTRERVLName=ERVL-B4-int
ADediting_1568375chr21_28873541_-LTRERVLName=ERVL-B4-int

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RNA A-to-I editing events in the alternative splicing sites for N6AMT1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for N6AMT1

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for N6AMT1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for N6AMT1

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1568373chr21_28873475_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-1915-5pchr2128873474288734807mer-m82887347328873493153-20.61
ADediting_1568373chr21_28873475_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-1915-5pchr2128873474288734807mer-m82887347328873493153-20.61
ADediting_1568374chr21_28873537_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-483-3pchr2128873534288735418mer-1a2887353428873554140-15.78
ADediting_1568374chr21_28873537_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-6837-3pchr2128873532288735387mer-m82887353128873554143-18.79
ADediting_1568374chr21_28873537_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-483-3pchr2128873534288735418mer-1a2887353428873554140-15.78
ADediting_1568374chr21_28873537_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-6837-3pchr2128873532288735387mer-m82887353128873554143-18.79
ADediting_954418chr21_28873461_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-664a-3pchr2128873458288734647mer-m82887345728873484154-18.47
ADediting_954418chr21_28873461_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-664a-3pchr2128873458288734647mer-m82887345728873484154-18.47
ADediting_954420chr21_28873493_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-6072chr2128873492288734987mer-m82887349128873512140-12.97
ADediting_954420chr21_28873493_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-6891-3pchr2128873492288734987mer-m82887349128873511145-12.04
ADediting_954420chr21_28873493_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-6072chr2128873492288734987mer-m82887349128873512140-12.97
ADediting_954420chr21_28873493_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-6891-3pchr2128873492288734987mer-m82887349128873511145-12.04
ADediting_954421chr21_28873516_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-4783-3pchr2128873514288735207mer-m82887351328873535157-23.08
ADediting_954421chr21_28873516_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-4783-3pchr2128873514288735207mer-m82887351328873535157-23.08
ADediting_954423chr21_28873593_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-181a-2-3pchr2128873589288735968mer-1a2887358928873609162-20.97
ADediting_954423chr21_28873593_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-6509-3pchr2128873588288735958mer-1a2887358828873609146-16.66
ADediting_954423chr21_28873593_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-181a-2-3pchr2128873589288735968mer-1a2887358928873609162-20.97
ADediting_954423chr21_28873593_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-6509-3pchr2128873588288735958mer-1a2887358828873609146-16.66
ADediting_954425chr21_28873600_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-4705chr2128873599288736068mer-1a2887359928873620150-17.28
ADediting_954425chr21_28873600_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-4705chr2128873599288736068mer-1a2887359928873620150-17.28
ADediting_954427chr21_28873622_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-122b-3pchr2128873616288736238mer-1a2887361628873637140-12.4
ADediting_954427chr21_28873622_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-21-3pchr2128873616288736238mer-1a2887361628873636159-17.77
ADediting_954427chr21_28873622_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-122b-3pchr2128873616288736238mer-1a2887361628873637140-12.4
ADediting_954427chr21_28873622_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-21-3pchr2128873616288736238mer-1a2887361628873636159-17.77
ADediting_954428chr21_28873629_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-6786-3pchr2128873627288736337mer-m82887362628873648152-22.53
ADediting_954428chr21_28873629_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-6786-3pchr2128873627288736337mer-m82887362628873648152-22.53
ADediting_954429chr21_28873634_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-5699-5pchr2128873629288736368mer-1a2887362928873647143-19.83
ADediting_954429chr21_28873634_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-6814-5pchr2128873632288736387mer-m82887363128873648142-21.04
ADediting_954429chr21_28873634_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-6830-5pchr2128873634288736407mer-m82887363328873654140-16.6
ADediting_954429chr21_28873634_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-5699-5pchr2128873629288736368mer-1a2887362928873647143-19.83
ADediting_954429chr21_28873634_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-6814-5pchr2128873632288736387mer-m82887363128873648142-21.04
ADediting_954429chr21_28873634_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-6830-5pchr2128873634288736407mer-m82887363328873654140-16.6
ADediting_954432chr21_28873668_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-3162-3pchr2128873666288736727mer-m82887366528873683146-18.19
ADediting_954432chr21_28873668_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-3162-3pchr2128873666288736727mer-m82887366528873683146-18.19
ADediting_954433chr21_28873669_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-197-3pchr2128873668288736747mer-m82887366728873689151-18.55
ADediting_954433chr21_28873669_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-4777-3pchr2128873663288736708mer-1a2887366328873683150-16.72
ADediting_954433chr21_28873669_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-6511a-3pchr2128873667288736737mer-m82887366628873686155-20.44
ADediting_954433chr21_28873669_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-6511b-3pchr2128873667288736737mer-m82887366628873687155-22.45
ADediting_954433chr21_28873669_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-197-3pchr2128873668288736747mer-m82887366728873689151-18.55
ADediting_954433chr21_28873669_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-4777-3pchr2128873663288736708mer-1a2887366328873683150-16.72
ADediting_954433chr21_28873669_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-6511a-3pchr2128873667288736737mer-m82887366628873686155-20.44
ADediting_954433chr21_28873669_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-6511b-3pchr2128873667288736737mer-m82887366628873687155-22.45
ADediting_954434chr21_28873792_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-1910-5pchr2128873787288737937mer-m82887378628873806150-17.69
ADediting_954434chr21_28873792_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-1910-5pchr2128873787288737937mer-m82887378628873806150-17.69
ADediting_954435chr21_28873793_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-371a-5pchr2128873790288737978mer-1a2887379028873809150-13.48
ADediting_954435chr21_28873793_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-372-5pchr2128873790288737967mer-1a2887379028873812141-7.84
ADediting_954435chr21_28873793_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-371a-5pchr2128873790288737978mer-1a2887379028873809150-13.48
ADediting_954435chr21_28873793_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-372-5pchr2128873790288737967mer-1a2887379028873812141-7.84
ADediting_954436chr21_28873910_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-194-3pchr2128873910288739167mer-m82887390928873932145-19.77
ADediting_954436chr21_28873910_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-194-3pchr2128873910288739167mer-m82887390928873932145-19.77

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1568373chr21_28873475_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-3121-5pchr2128873473288734797mer-m82887347228873493150-19.31
ADediting_1568373chr21_28873475_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-4755-5pchr2128873470288734767mer-m82887346928873490140-15.08
ADediting_1568373chr21_28873475_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-5006-3pchr2128873470288734767mer-m82887346928873489153-18.12
ADediting_1568373chr21_28873475_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-3121-5pchr2128873473288734797mer-m82887347228873493150-19.31
ADediting_1568373chr21_28873475_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-4755-5pchr2128873470288734767mer-m82887346928873490140-15.08
ADediting_1568373chr21_28873475_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-5006-3pchr2128873470288734767mer-m82887346928873489153-18.12
ADediting_1568375chr21_28873541_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-4766-5pchr2128873540288735467mer-m82887353928873564142-16.17
ADediting_1568375chr21_28873541_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-488-3pchr2128873541288735477mer-m82887354028873562149-15.83
ADediting_1568375chr21_28873541_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-4766-5pchr2128873540288735467mer-m82887353928873564142-16.17
ADediting_1568375chr21_28873541_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-488-3pchr2128873541288735477mer-m82887354028873562149-15.83
ADediting_954418chr21_28873461_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-4729chr2128873457288734637mer-m82887345628873478151-11.88
ADediting_954418chr21_28873461_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-4729chr2128873457288734637mer-m82887345628873478151-11.88
ADediting_954422chr21_28873550_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-4782-5pchr2128873548288735547mer-m82887354728873569143-10.76
ADediting_954422chr21_28873550_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-5706chr2128873548288735547mer-m82887354728873567143-10.35
ADediting_954422chr21_28873550_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-4782-5pchr2128873548288735547mer-m82887354728873569143-10.76
ADediting_954422chr21_28873550_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-5706chr2128873548288735547mer-m82887354728873567143-10.35
ADediting_954428chr21_28873629_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-3157-3pchr2128873629288736357mer-m82887362828873649141-14.99
ADediting_954428chr21_28873629_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-4708-5pchr2128873625288736317mer-m82887362428873644145-18.59
ADediting_954428chr21_28873629_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-3157-3pchr2128873629288736357mer-m82887362828873649141-14.99
ADediting_954428chr21_28873629_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-4708-5pchr2128873625288736317mer-m82887362428873644145-18.59
ADediting_954429chr21_28873634_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-18b-3pchr2128873629288736368mer-1a2887362928873650144-16.82
ADediting_954429chr21_28873634_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-3157-3pchr2128873629288736357mer-m82887362828873649141-14.99
ADediting_954429chr21_28873634_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-18b-3pchr2128873629288736368mer-1a2887362928873650144-16.82
ADediting_954429chr21_28873634_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-3157-3pchr2128873629288736357mer-m82887362828873649141-14.99
ADediting_954430chr21_28873648_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-10395-3pchr2128873646288736527mer-m82887364528873666148-9.17
ADediting_954430chr21_28873648_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-223-5pchr2128873644288736518mer-1a2887364428873667152-10.98
ADediting_954430chr21_28873648_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-10395-3pchr2128873646288736527mer-m82887364528873666148-9.17
ADediting_954430chr21_28873648_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-223-5pchr2128873644288736518mer-1a2887364428873667152-10.98
ADediting_954434chr21_28873792_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-302a-5pchr2128873790288737978mer-1a2887379028873813148-6.67
ADediting_954434chr21_28873792_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-302a-5pchr2128873790288737978mer-1a2887379028873813148-6.67
ADediting_954435chr21_28873793_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-302a-5pchr2128873790288737978mer-1a2887379028873813148-6.67
ADediting_954435chr21_28873793_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-302a-5pchr2128873790288737978mer-1a2887379028873813148-6.67
ADediting_954436chr21_28873910_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-449c-3pchr2128873906288739138mer-1a2887390628873928148-14.54
ADediting_954436chr21_28873910_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-4727-3pchr2128873910288739167mer-m82887390928873932151-17.53
ADediting_954436chr21_28873910_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-449c-3pchr2128873906288739138mer-1a2887390628873928148-14.54
ADediting_954436chr21_28873910_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-4727-3pchr2128873910288739167mer-m82887390928873932151-17.53

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337757chr7_5495852_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-589-3pchr2128874022288740298mer-1a2887402228874045154-18.79
ADediting_1337757chr7_5495852_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-589-3pchr2128875534288755407mer-m82887553328875558147-21.84
ADediting_1337757chr7_5495852_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-589-3pchr2128874022288740298mer-1a2887402228874045154-18.79
ADediting_1337757chr7_5495852_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-589-3pchr2128875534288755407mer-m82887553328875558147-21.84
ADediting_1391023chr8_140732605_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-151a-3pchr2128876083288760897mer-m82887608228876102140-12.03
ADediting_1391023chr8_140732605_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-151a-3pchr2128876083288760897mer-m82887608228876102140-12.03
ADediting_1535953chr14_101045971_+ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-381-3pchr2128875728288757347mer-m82887572728875748146-10.36
ADediting_1535953chr14_101045971_+ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-381-3pchr2128875728288757347mer-m82887572728875748146-10.36
ADediting_1556067chr19_40282625_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-641chr2128874250288742578mer-1a2887425028874273150-14.71
ADediting_1556067chr19_40282625_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-641chr2128874250288742578mer-1a2887425028874273150-14.71
ADediting_1631458chr19_40282624_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-641chr2128873384288733907mer-m82887338328873408159-17.85
ADediting_1631458chr19_40282624_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-641chr2128873384288733907mer-m82887338328873408159-17.85
ADediting_286380chr11_79422188_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-5579-3pchr2128872605288726117mer-m82887260428872626150-11.73
ADediting_286380chr11_79422188_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-5579-3pchr2128872605288726117mer-m82887260428872626150-11.73
ADediting_98288chr1_32086990_+ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-5585-3pchr2128874513288745197mer-m82887451228874531147-13.65
ADediting_98288chr1_32086990_+ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-5585-3pchr2128874513288745197mer-m82887451228874531147-13.65

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-5688chr2128872841288728477mer-m82887284028872861140-13.04
ADediting_1097295chr3_85385762_+ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-5688chr2128872841288728477mer-m82887284028872861140-13.04
ADediting_1337757chr7_5495852_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-589-3pchr2128874636288746427mer-m82887463528874658140-13.89
ADediting_1337757chr7_5495852_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-589-3pchr2128875014288750207mer-m82887501328875036140-17.43
ADediting_1337757chr7_5495852_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-589-3pchr2128874636288746427mer-m82887463528874658140-13.89
ADediting_1337757chr7_5495852_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-589-3pchr2128875014288750207mer-m82887501328875036140-17.43
ADediting_1337758chr7_5495892_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-589-5pchr2128872707288727148mer-1a2887270728872728149-17.52
ADediting_1337758chr7_5495892_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-589-5pchr2128872707288727148mer-1a2887270728872728149-17.52
ADediting_496066chr15_66496985_-ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-4512chr2128875179288751857mer-m82887517828875199150-27.51
ADediting_496066chr15_66496985_-ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-4512chr2128875179288751857mer-m82887517828875199150-27.51
ADediting_527135chr16_24203190_+ENSG00000156239.12ENST00000303775.10N6AMT1-201hsa-miR-1273h-3pchr2128875564288755718mer-1a2887556428875585150-17.34
ADediting_527135chr16_24203190_+ENSG00000156239.12ENST00000351429.7N6AMT1-202hsa-miR-1273h-3pchr2128875564288755718mer-1a2887556428875585150-17.34

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for N6AMT1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000303775.10protein_codingSoverviewSoverview
ENST00000351429.7protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_954418ENST00000303775.10chr21_28873461_-3591-1504.90-1505.10-1523.50
ADediting_1568373ENST00000303775.10chr21_28873475_-3577-1504.80-1505.10-1523.50
ADediting_954419ENST00000303775.10chr21_28873481_-3571-1505.90-1505.10-1523.50
ADediting_954420ENST00000303775.10chr21_28873493_-3559-1506.70-1505.10-1523.50
ADediting_954421ENST00000303775.10chr21_28873516_-3536-1505.60-1505.10-1523.50
ADediting_1568374ENST00000303775.10chr21_28873537_-3515-1505.00-1505.10-1523.50
ADediting_1568375ENST00000303775.10chr21_28873541_-3511-1504.20-1505.10-1523.50
ADediting_954422ENST00000303775.10chr21_28873550_-3502-1504.30-1505.10-1523.50
ADediting_954423ENST00000303775.10chr21_28873593_-3459-1508.00-1505.10-1523.50
ADediting_954424ENST00000303775.10chr21_28873599_-3453-1508.40-1505.10-1523.50
ADediting_954425ENST00000303775.10chr21_28873600_-3452-1505.80-1505.10-1523.50
ADediting_954426ENST00000303775.10chr21_28873616_-3436-1507.70-1505.10-1523.50
ADediting_954427ENST00000303775.10chr21_28873622_-3430-1506.20-1505.10-1523.50
ADediting_954428ENST00000303775.10chr21_28873629_-3423-1508.40-1505.10-1523.50
ADediting_954429ENST00000303775.10chr21_28873634_-3418-1504.80-1505.10-1523.50
ADediting_954430ENST00000303775.10chr21_28873648_-3404-1506.50-1505.10-1523.50
ADediting_954431ENST00000303775.10chr21_28873663_-3389-1505.60-1505.10-1523.50
ADediting_954432ENST00000303775.10chr21_28873668_-3384-1504.70-1505.10-1523.50
ADediting_954433ENST00000303775.10chr21_28873669_-3383-1505.20-1505.10-1523.50
ADediting_954434ENST00000303775.10chr21_28873792_-3260-1508.80-1505.10-1523.50
ADediting_954435ENST00000303775.10chr21_28873793_-3259-1505.50-1505.10-1523.50
ADediting_954436ENST00000303775.10chr21_28873910_-3142-1505.10-1505.10-1523.50
ADediting_954418ENST00000351429.7chr21_28873461_-3511-1475.50-1475.70-1493.60
ADediting_1568373ENST00000351429.7chr21_28873475_-3497-1475.40-1475.70-1493.60
ADediting_954419ENST00000351429.7chr21_28873481_-3491-1476.50-1475.70-1493.60
ADediting_954420ENST00000351429.7chr21_28873493_-3479-1477.30-1475.70-1493.60
ADediting_954421ENST00000351429.7chr21_28873516_-3456-1476.20-1475.70-1493.60
ADediting_1568374ENST00000351429.7chr21_28873537_-3435-1475.60-1475.70-1493.60
ADediting_1568375ENST00000351429.7chr21_28873541_-3431-1474.80-1475.70-1493.60
ADediting_954422ENST00000351429.7chr21_28873550_-3422-1474.90-1475.70-1493.60
ADediting_954423ENST00000351429.7chr21_28873593_-3379-1478.60-1475.70-1493.60
ADediting_954424ENST00000351429.7chr21_28873599_-3373-1479.00-1475.70-1493.60
ADediting_954425ENST00000351429.7chr21_28873600_-3372-1476.40-1475.70-1493.60
ADediting_954426ENST00000351429.7chr21_28873616_-3356-1478.30-1475.70-1493.60
ADediting_954427ENST00000351429.7chr21_28873622_-3350-1476.80-1475.70-1493.60
ADediting_954428ENST00000351429.7chr21_28873629_-3343-1477.90-1475.70-1493.60
ADediting_954429ENST00000351429.7chr21_28873634_-3338-1475.40-1475.70-1493.60
ADediting_954430ENST00000351429.7chr21_28873648_-3324-1477.10-1475.70-1493.60
ADediting_954431ENST00000351429.7chr21_28873663_-3309-1479.30-1475.70-1493.60
ADediting_954432ENST00000351429.7chr21_28873668_-3304-1477.20-1475.70-1493.60
ADediting_954433ENST00000351429.7chr21_28873669_-3303-1475.80-1475.70-1493.60
ADediting_954434ENST00000351429.7chr21_28873792_-3180-1478.30-1475.70-1493.60
ADediting_954435ENST00000351429.7chr21_28873793_-3179-1476.10-1475.70-1493.60
ADediting_954436ENST00000351429.7chr21_28873910_-3062-1475.70-1475.70-1493.60

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for N6AMT1

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CERADediting_954428chr21_28873629_-7.44895393245096e-060.3567028955529821.88663603127239e-080.439175097436610.230657422207690.0984564045357876
CERADediting_954436chr21_28873910_-0.0006818613030121990.2743005462044913.23038634522482e-050.3324599350788440.3903088062473450.0706450385669198

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC1.32259687811482e-470.7035304661107221.54411111034268e-590.7597855067064030.1924372192994780.0742260134615381
AC6.52700151814038e-490.7630500935830342.10282704637136e-290.6330558103699191.06375089758846e-260.608358905526148
PCC5.4639158805836e-410.7839557872838373.61490601208103e-460.812499716042267.4953567918319e-050.282529553706482
CER9.97568631296986e-190.6410175813922088.47472158339681e-070.3893296161198880.1657774696053070.113742175366696
TCX2.0744990083421e-150.589531536231290.02123697796563530.1879922928559998.98108261616421e-100.473981266289299
FP2.55167616168797e-230.6565196122593498.81833975810423e-290.7115781543479582.79422684784654e-050.308504577678052
IFG6.30096713504707e-050.7131461297103440.001211874750160120.6097637739211560.03156389878259890.430804948678973
PG1.53713317197412e-420.7991990584861612.00436683951667e-260.6783627903855570.1321119046912280.110819202911858
STG1.20866520508975e-120.6793838068591051.3145350629336e-110.655562613598680.02069954382080920.252100650984855

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Relation with AD stages for N6AMT1

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
TCX1.72849705368095e-050.404231143231527

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RelatedDrugs for N6AMT1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for N6AMT1

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource