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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for DROSHA |
 Gene summary |
| Gene information | Gene symbol | DROSHA | Gene ID | 29102 |
| Gene name | drosha ribonuclease III | |
| Synonyms | ETOHI2|HSA242976|RANSE3L|RN3|RNASE3L|RNASEN | |
| Cytomap | 5p13.3 | |
| Type of gene | protein-coding | |
| Description | ribonuclease 3RNase IIIdrosha, double-stranded RNA-specific endoribonucleasenuclear RNase III Droshap241putative protein p241 which interacts with transcription factor Sp1putative ribonuclease IIIribonuclease type III, nuclear | |
| Modification date | 20200313 | |
| UniProtAcc | Q9NRR4, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| DROSHA | GO:0031053 | primary miRNA processing | 14508493|15574589 |
| DROSHA | GO:0050829 | defense response to Gram-negative bacterium | 20180804 |
| DROSHA | GO:0050830 | defense response to Gram-positive bacterium | 20180804 |
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RNA A-to-I events for DROSHA |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1195902(31402911, -), ADediting_1195903(31402920, -), ADediting_1195904(31402921, -), ADediting_1195905(31402947, -), ADediting_1195906(31403053, -), ADediting_1195907(31403980, -), ADediting_1195908(31404058, -), ADediting_1195909(31405182, -), ADediting_1195910(31405187, -), ADediting_1195911(31405244, -), ADediting_1195912(31405268, -), ADediting_1195913(31405312, -), ADediting_1195914(31443112, -), ADediting_1195915(31443116, -), ADediting_1195916(31443131, -), ADediting_1195917(31443157, -), ADediting_1195918(31457262, -), ADediting_1195919(31457291, -), ADediting_1195920(31457292, -), ADediting_1195921(31457357, -), ADediting_1195922(31457397, -), ADediting_1195923(31457398, -), ADediting_1195924(31457633, -), ADediting_1195925(31457672, -), ADediting_1195926(31457673, -), ADediting_1195927(31457679, -), ADediting_1195928(31457687, -), ADediting_1195929(31457742, -), ADediting_1195930(31457768, -), ADediting_1195931(31457778, -), ADediting_1195932(31457781, -), ADediting_1195933(31457790, -), ADediting_1195934(31457795, -), ADediting_1195935(31457814, -), ADediting_1195936(31457830, -), ADediting_1195937(31457857, -), ADediting_1195938(31474435, -), ADediting_1195939(31474455, -), ADediting_1195940(31474460, -), ADediting_1195941(31474478, -), ADediting_1195942(31474491, -), ADediting_1195943(31474501, -), ADediting_1195944(31474530, -), ADediting_1195945(31474531, -), ADediting_1195946(31474539, -), ADediting_1195947(31474540, -), ADediting_1195948(31474541, -), ADediting_1195949(31474542, -), ADediting_1195950(31474543, -), ADediting_1195951(31474563, -), ADediting_1195952(31474567, -), ADediting_1195953(31474591, -), ADediting_1195954(31474614, -), ADediting_1195955(31474636, -), ADediting_1195956(31474637, -), ADediting_1195957(31475151, -), ADediting_1195958(31475170, -), ADediting_1195959(31475186, -), ADediting_1195960(31475196, -), ADediting_1195961(31475206, -), ADediting_1195962(31475236, -), ADediting_1195963(31475280, -), ADediting_1195964(31488151, -), ADediting_1195965(31488152, -), ADediting_1195966(31488154, -), ADediting_1195967(31488166, -), ADediting_1195968(31488225, -), ADediting_1195969(31488251, -), ADediting_1195970(31488254, -), ADediting_1195971(31491918, -), ADediting_1195972(31498745, -), ADediting_1581334(31402900, -), ADediting_1581335(31402950, -), ADediting_1581336(31402965, -), ADediting_1581337(31404039, -), ADediting_1581338(31405204, -), ADediting_1581339(31405224, -), ADediting_1581340(31441193, -), ADediting_1656527(31488237, -), |
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RNA editing positional annotations for DROSHA using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1195902 | chr5_31402911_- | intronic |
| ADediting_1195903 | chr5_31402920_- | intronic |
| ADediting_1195904 | chr5_31402921_- | intronic |
| ADediting_1195905 | chr5_31402947_- | intronic |
| ADediting_1195906 | chr5_31403053_- | intronic |
| ADediting_1195907 | chr5_31403980_- | intronic |
| ADediting_1195908 | chr5_31404058_- | intronic |
| ADediting_1195909 | chr5_31405182_- | intronic |
| ADediting_1195910 | chr5_31405187_- | intronic |
| ADediting_1195911 | chr5_31405244_- | intronic |
| ADediting_1195912 | chr5_31405268_- | intronic |
| ADediting_1195913 | chr5_31405312_- | intronic |
| ADediting_1195914 | chr5_31443112_- | intronic |
| ADediting_1195915 | chr5_31443116_- | intronic |
| ADediting_1195916 | chr5_31443131_- | intronic |
| ADediting_1195917 | chr5_31443157_- | intronic |
| ADediting_1195918 | chr5_31457262_- | intronic |
| ADediting_1195919 | chr5_31457291_- | intronic |
| ADediting_1195920 | chr5_31457292_- | intronic |
| ADediting_1195921 | chr5_31457357_- | intronic |
| ADediting_1195922 | chr5_31457397_- | intronic |
| ADediting_1195923 | chr5_31457398_- | intronic |
| ADediting_1195924 | chr5_31457633_- | intronic |
| ADediting_1195925 | chr5_31457672_- | intronic |
| ADediting_1195926 | chr5_31457673_- | intronic |
| ADediting_1195927 | chr5_31457679_- | intronic |
| ADediting_1195928 | chr5_31457687_- | intronic |
| ADediting_1195929 | chr5_31457742_- | intronic |
| ADediting_1195930 | chr5_31457768_- | intronic |
| ADediting_1195931 | chr5_31457778_- | intronic |
| ADediting_1195932 | chr5_31457781_- | intronic |
| ADediting_1195933 | chr5_31457790_- | intronic |
| ADediting_1195934 | chr5_31457795_- | intronic |
| ADediting_1195935 | chr5_31457814_- | intronic |
| ADediting_1195936 | chr5_31457830_- | intronic |
| ADediting_1195937 | chr5_31457857_- | intronic |
| ADediting_1195938 | chr5_31474435_- | intronic |
| ADediting_1195939 | chr5_31474455_- | intronic |
| ADediting_1195940 | chr5_31474460_- | intronic |
| ADediting_1195941 | chr5_31474478_- | intronic |
| ADediting_1195942 | chr5_31474491_- | intronic |
| ADediting_1195943 | chr5_31474501_- | intronic |
| ADediting_1195944 | chr5_31474530_- | intronic |
| ADediting_1195945 | chr5_31474531_- | intronic |
| ADediting_1195946 | chr5_31474539_- | intronic |
| ADediting_1195947 | chr5_31474540_- | intronic |
| ADediting_1195948 | chr5_31474541_- | intronic |
| ADediting_1195949 | chr5_31474542_- | intronic |
| ADediting_1195950 | chr5_31474543_- | intronic |
| ADediting_1195951 | chr5_31474563_- | intronic |
| ADediting_1195952 | chr5_31474567_- | intronic |
| ADediting_1195953 | chr5_31474591_- | intronic |
| ADediting_1195954 | chr5_31474614_- | intronic |
| ADediting_1195955 | chr5_31474636_- | intronic |
| ADediting_1195956 | chr5_31474637_- | intronic |
| ADediting_1195957 | chr5_31475151_- | intronic |
| ADediting_1195958 | chr5_31475170_- | intronic |
| ADediting_1195959 | chr5_31475186_- | intronic |
| ADediting_1195960 | chr5_31475196_- | intronic |
| ADediting_1195961 | chr5_31475206_- | intronic |
| ADediting_1195962 | chr5_31475236_- | intronic |
| ADediting_1195963 | chr5_31475280_- | intronic |
| ADediting_1195964 | chr5_31488151_- | intronic |
| ADediting_1195965 | chr5_31488152_- | intronic |
| ADediting_1195966 | chr5_31488154_- | intronic |
| ADediting_1195967 | chr5_31488166_- | intronic |
| ADediting_1195968 | chr5_31488225_- | intronic |
| ADediting_1195969 | chr5_31488251_- | intronic |
| ADediting_1195970 | chr5_31488254_- | intronic |
| ADediting_1195971 | chr5_31491918_- | intronic |
| ADediting_1195972 | chr5_31498745_- | intronic |
| ADediting_1581334 | chr5_31402900_- | intronic |
| ADediting_1581335 | chr5_31402950_- | intronic |
| ADediting_1581336 | chr5_31402965_- | intronic |
| ADediting_1581337 | chr5_31404039_- | intronic |
| ADediting_1581338 | chr5_31405204_- | intronic |
| ADediting_1581339 | chr5_31405224_- | intronic |
| ADediting_1581340 | chr5_31441193_- | intronic |
| ADediting_1656527 | chr5_31488237_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1195902 | chr5_31402911_- | SINE | Alu | Name=AluSz6 |
| ADediting_1195903 | chr5_31402920_- | SINE | Alu | Name=AluSz6 |
| ADediting_1195904 | chr5_31402921_- | SINE | Alu | Name=AluSz6 |
| ADediting_1195905 | chr5_31402947_- | SINE | Alu | Name=AluSz6 |
| ADediting_1195906 | chr5_31403053_- | SINE | Alu | Name=AluSz6 |
| ADediting_1195907 | chr5_31403980_- | SINE | Alu | Name=AluJo |
| ADediting_1195908 | chr5_31404058_- | SINE | Alu | Name=AluJo |
| ADediting_1195909 | chr5_31405182_- | SINE | Alu | Name=AluSq |
| ADediting_1195910 | chr5_31405187_- | SINE | Alu | Name=AluSq |
| ADediting_1195911 | chr5_31405244_- | SINE | Alu | Name=AluSq |
| ADediting_1195912 | chr5_31405268_- | SINE | Alu | Name=AluSq |
| ADediting_1195913 | chr5_31405312_- | SINE | Alu | Name=AluSq |
| ADediting_1195914 | chr5_31443112_- | SINE | Alu | Name=AluSx1 |
| ADediting_1195915 | chr5_31443116_- | SINE | Alu | Name=AluSx1 |
| ADediting_1195916 | chr5_31443131_- | SINE | Alu | Name=AluSx1 |
| ADediting_1195917 | chr5_31443157_- | SINE | Alu | Name=AluSx1 |
| ADediting_1195918 | chr5_31457262_- | SINE | Alu | Name=AluSx |
| ADediting_1195919 | chr5_31457291_- | SINE | Alu | Name=AluSx |
| ADediting_1195920 | chr5_31457292_- | SINE | Alu | Name=AluSx |
| ADediting_1195921 | chr5_31457357_- | SINE | Alu | Name=AluSx |
| ADediting_1195922 | chr5_31457397_- | SINE | Alu | Name=AluSx |
| ADediting_1195923 | chr5_31457398_- | SINE | Alu | Name=AluSx |
| ADediting_1195924 | chr5_31457633_- | SINE | Alu | Name=AluJo |
| ADediting_1195925 | chr5_31457672_- | SINE | Alu | Name=AluJo |
| ADediting_1195926 | chr5_31457673_- | SINE | Alu | Name=AluJo |
| ADediting_1195927 | chr5_31457679_- | SINE | Alu | Name=AluJo |
| ADediting_1195928 | chr5_31457687_- | SINE | Alu | Name=AluJo |
| ADediting_1195929 | chr5_31457742_- | SINE | Alu | Name=AluJo |
| ADediting_1195930 | chr5_31457768_- | SINE | Alu | Name=AluJo |
| ADediting_1195931 | chr5_31457778_- | SINE | Alu | Name=AluJo |
| ADediting_1195932 | chr5_31457781_- | SINE | Alu | Name=AluJo |
| ADediting_1195933 | chr5_31457790_- | SINE | Alu | Name=AluJo |
| ADediting_1195934 | chr5_31457795_- | SINE | Alu | Name=AluJo |
| ADediting_1195935 | chr5_31457814_- | SINE | Alu | Name=AluJo |
| ADediting_1195936 | chr5_31457830_- | SINE | Alu | Name=AluJo |
| ADediting_1195937 | chr5_31457857_- | SINE | Alu | Name=AluJo |
| ADediting_1195938 | chr5_31474435_- | SINE | Alu | Name=AluJb |
| ADediting_1195939 | chr5_31474455_- | SINE | Alu | Name=AluJb |
| ADediting_1195940 | chr5_31474460_- | SINE | Alu | Name=AluJb |
| ADediting_1195941 | chr5_31474478_- | SINE | Alu | Name=AluJb |
| ADediting_1195942 | chr5_31474491_- | SINE | Alu | Name=AluJb |
| ADediting_1195943 | chr5_31474501_- | SINE | Alu | Name=AluJb |
| ADediting_1195944 | chr5_31474530_- | SINE | Alu | Name=AluJb |
| ADediting_1195945 | chr5_31474531_- | SINE | Alu | Name=AluJb |
| ADediting_1195946 | chr5_31474539_- | SINE | Alu | Name=AluJb |
| ADediting_1195947 | chr5_31474540_- | SINE | Alu | Name=AluJb |
| ADediting_1195948 | chr5_31474541_- | SINE | Alu | Name=AluJb |
| ADediting_1195949 | chr5_31474542_- | SINE | Alu | Name=AluJb |
| ADediting_1195950 | chr5_31474543_- | SINE | Alu | Name=AluJb |
| ADediting_1195951 | chr5_31474563_- | SINE | Alu | Name=AluJb |
| ADediting_1195952 | chr5_31474567_- | SINE | Alu | Name=AluJb |
| ADediting_1195953 | chr5_31474591_- | SINE | Alu | Name=AluJb |
| ADediting_1195954 | chr5_31474614_- | SINE | Alu | Name=AluJb |
| ADediting_1195955 | chr5_31474636_- | SINE | Alu | Name=AluJb |
| ADediting_1195956 | chr5_31474637_- | SINE | Alu | Name=AluJb |
| ADediting_1195957 | chr5_31475151_- | SINE | Alu | Name=AluJb |
| ADediting_1195958 | chr5_31475170_- | SINE | Alu | Name=AluJb |
| ADediting_1195959 | chr5_31475186_- | SINE | Alu | Name=AluJb |
| ADediting_1195960 | chr5_31475196_- | SINE | Alu | Name=AluJb |
| ADediting_1195961 | chr5_31475206_- | SINE | Alu | Name=AluJb |
| ADediting_1195962 | chr5_31475236_- | SINE | Alu | Name=AluJb |
| ADediting_1195963 | chr5_31475280_- | SINE | Alu | Name=AluJb |
| ADediting_1195964 | chr5_31488151_- | SINE | Alu | Name=AluSq |
| ADediting_1195965 | chr5_31488152_- | SINE | Alu | Name=AluSq |
| ADediting_1195966 | chr5_31488154_- | SINE | Alu | Name=AluSq |
| ADediting_1195967 | chr5_31488166_- | SINE | Alu | Name=AluSq |
| ADediting_1195968 | chr5_31488225_- | SINE | Alu | Name=AluSq |
| ADediting_1195969 | chr5_31488251_- | SINE | Alu | Name=AluSq |
| ADediting_1195970 | chr5_31488254_- | SINE | Alu | Name=AluSq |
| ADediting_1195971 | chr5_31491918_- | SINE | Alu | Name=AluSz6 |
| ADediting_1195972 | chr5_31498745_- | SINE | Alu | Name=AluSp |
| ADediting_1581334 | chr5_31402900_- | SINE | Alu | Name=AluSz6 |
| ADediting_1581335 | chr5_31402950_- | SINE | Alu | Name=AluSz6 |
| ADediting_1581336 | chr5_31402965_- | SINE | Alu | Name=AluSz6 |
| ADediting_1581337 | chr5_31404039_- | SINE | Alu | Name=AluJo |
| ADediting_1581338 | chr5_31405204_- | SINE | Alu | Name=AluSq |
| ADediting_1581339 | chr5_31405224_- | SINE | Alu | Name=AluSq |
| ADediting_1581340 | chr5_31441193_- | SINE | Alu | Name=AluJr |
| ADediting_1656527 | chr5_31488237_- | SINE | Alu | Name=AluSq |
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RNA A-to-I editing events in the alternative splicing sites for DROSHA |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for DROSHA |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for DROSHA |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for DROSHA |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_286380 | chr11_79422188_- | ENSG00000113360.16 | ENST00000344624.7 | DROSHA-201 | hsa-miR-5579-3p | chr5 | 31400800 | 31400806 | 7mer-m8 | 31400799 | 31400819 | 145 | -14.53 |
| ADediting_286380 | chr11_79422188_- | ENSG00000113360.16 | ENST00000442743.5 | DROSHA-202 | hsa-miR-5579-3p | chr5 | 31400800 | 31400806 | 7mer-m8 | 31400799 | 31400819 | 145 | -14.53 |
| ADediting_286380 | chr11_79422188_- | ENSG00000113360.16 | ENST00000511367.6 | DROSHA-212 | hsa-miR-5579-3p | chr5 | 31400800 | 31400806 | 7mer-m8 | 31400799 | 31400819 | 145 | -14.53 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_291761 | chr11_93733708_- | ENSG00000113360.16 | ENST00000344624.7 | DROSHA-201 | hsa-miR-1304-3p | chr5 | 31400923 | 31400929 | 7mer-m8 | 31400922 | 31400945 | 142 | -12.77 |
| ADediting_291761 | chr11_93733708_- | ENSG00000113360.16 | ENST00000442743.5 | DROSHA-202 | hsa-miR-1304-3p | chr5 | 31400923 | 31400929 | 7mer-m8 | 31400922 | 31400945 | 142 | -12.77 |
| ADediting_291761 | chr11_93733708_- | ENSG00000113360.16 | ENST00000511367.6 | DROSHA-212 | hsa-miR-1304-3p | chr5 | 31400923 | 31400929 | 7mer-m8 | 31400922 | 31400945 | 142 | -12.77 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for DROSHA |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for DROSHA |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_1195909 | chr5_31405182_- | 0.00178146912810266 | 0.176770583041544 | 0.21077147415831 | 0.0712749126232426 | 2.72355038257506e-09 | 0.329636259967696 |
| CER | ADediting_1195909 | chr5_31405182_- | 0.000241092912295459 | 0.295528009746314 | 3.52691467916953e-09 | 0.458825088083848 | 0.0354996630310647 | 0.171835960745753 |
| CER | ADediting_1195910 | chr5_31405187_- | 0.00315857251369542 | 0.239504624745733 | 3.87266983301134e-07 | 0.400271971543191 | 0.0860662225122425 | 0.140632633649381 |
| CER | ADediting_1195912 | chr5_31405268_- | 0.00634636107271211 | 0.221919357491909 | 6.86223002450017e-07 | 0.392317475432199 | 0.0696861882897448 | 0.148527883727015 |
| DLPFC | ADediting_1195918 | chr5_31457262_- | 0.646702379420111 | -0.0261335486396439 | 0.0363919131146261 | -0.118905629449229 | 1.15538483839335e-13 | 0.404970034983406 |
| DLPFC | ADediting_1195921 | chr5_31457357_- | 0.751628156614233 | 0.018047049627533 | 0.10375324835611 | -0.0925785242522318 | 5.2405534818892e-16 | 0.438612091408901 |
| DLPFC | ADediting_1195928 | chr5_31457687_- | 0.629499344282633 | -0.0275062096002639 | 0.0491450570043634 | -0.111837922416238 | 7.13223246577052e-15 | 0.422802065740757 |
| DLPFC | ADediting_1195930 | chr5_31457768_- | 0.133067715477353 | -0.0855034398457151 | 0.00436971402585245 | -0.161467009085704 | 4.13890214049306e-08 | 0.305282189032713 |
| DLPFC | ADediting_1195931 | chr5_31457778_- | 0.123399500949197 | -0.0876892275250072 | 0.0091286420881891 | -0.147861444279725 | 7.54979411145021e-10 | 0.340411455617794 |
| DLPFC | ADediting_1195939 | chr5_31474455_- | 0.423487638498575 | -0.0456194455235266 | 0.00567123779054958 | -0.156770762309135 | 4.94750918497241e-14 | 0.41051366137128 |
| DLPFC | ADediting_1195962 | chr5_31475236_- | 0.871269264710014 | -0.00924075458534875 | 0.0467535669557125 | -0.113035101156229 | 2.93602135736115e-15 | 0.428270080452162 |
| CER | ADediting_1581338 | chr5_31405204_- | 0.00673412056946181 | 0.220364132539513 | 2.24710937188186e-06 | 0.375128687891355 | 0.0115339984403444 | 0.205763716713205 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 7.31052623996541e-27 | 0.558860872467335 | 2.08408623313993e-62 | 0.771355628307641 | 0.455522179399246 | 0.0425362587929005 |
| AC | 1.27671996752552e-52 | 0.78100842716464 | 2.29400187475612e-52 | 0.779827751690923 | 8.10517556094e-11 | 0.396063960302156 |
| PCC | 1.0047337988936e-28 | 0.693549852533951 | 1.00108378514088e-33 | 0.735037922467091 | 0.00569139405874461 | 0.199368225271903 |
| CER | 0.531867348360451 | 0.0514404517229608 | 0.00016845173209872 | 0.302481837260732 | 0.0476160825892747 | 0.162015098033661 |
| TCX | 1.16192564581761e-09 | 0.471183611777646 | 3.07507219424622e-16 | 0.603301013835117 | 0.457235308652309 | -0.0611536640300167 |
| FP | 1.46872855129741e-27 | 0.700286026209391 | 3.24206825586239e-29 | 0.715468593948753 | 0.0366677963863525 | 0.156745357034452 |
| IFG | 2.10870141874657e-07 | 0.834866802182976 | 2.42497560213468e-05 | 0.739258753975755 | 0.222159552465608 | 0.253119586890521 |
| PG | 1.49057700303352e-54 | 0.855768896972173 | 3.20404971274435e-32 | 0.72986928021504 | 0.916316906286589 | 0.00775659019629454 |
| STG | 4.86598802383846e-25 | 0.854478973006534 | 6.21797694306151e-13 | 0.685644103387306 | 0.178876895540791 | 0.14807532816376 |
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Relation with AD stages for DROSHA |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 0.000176721110967029 | 0.353262903870191 |
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RelatedDrugs for DROSHA |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DROSHA |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| DROSHA | C0021364 | Male infertility | 1 | CTD_human |
| DROSHA | C0027708 | Nephroblastoma | 1 | CTD_human |
| DROSHA | C0036341 | Schizophrenia | 1 | PSYGENET |
| DROSHA | C0848676 | Subfertility, Male | 1 | CTD_human |
| DROSHA | C0917731 | Male sterility | 1 | CTD_human |
| DROSHA | C2930471 | Bilateral Wilms Tumor | 1 | CTD_human |
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