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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for KLF15 |
 Gene summary |
| Gene information | Gene symbol | KLF15 | Gene ID | 28999 |
| Gene name | Kruppel like factor 15 | |
| Synonyms | KKLF | |
| Cytomap | 3q21.3 | |
| Type of gene | protein-coding | |
| Description | Krueppel-like factor 15kidney-enriched Kruppel-like factorkidney-enriched krueppel-like factor | |
| Modification date | 20200327 | |
| UniProtAcc | Q9UIH9, | |
| Context | - 32140387(Disturbed Yin-Yang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for KLF15 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1019401(126349528, -), ADediting_1019402(126349529, -), ADediting_1019403(126349533, -), ADediting_1019404(126349536, -), ADediting_1019405(126353613, -), |
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RNA editing positional annotations for KLF15 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1019401 | chr3_126349528_- | intronic |
| ADediting_1019402 | chr3_126349529_- | intronic |
| ADediting_1019403 | chr3_126349533_- | intronic |
| ADediting_1019404 | chr3_126349536_- | intronic |
| ADediting_1019405 | chr3_126353613_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1019401 | chr3_126349528_- | LINE | CR1 | Name=L3 |
| ADediting_1019402 | chr3_126349529_- | LINE | CR1 | Name=L3 |
| ADediting_1019403 | chr3_126349533_- | LINE | CR1 | Name=L3 |
| ADediting_1019404 | chr3_126349536_- | LINE | CR1 | Name=L3 |
| ADediting_1019405 | chr3_126353613_- | DNA | hAT-Blackjack | Name=MER53 |
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RNA A-to-I editing events in the alternative splicing sites for KLF15 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for KLF15 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for KLF15 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for KLF15 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for KLF15 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for KLF15 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| PCC | ADediting_1019404 | chr3_126349536_- | 0.109560214469419 | -0.116154669189806 | 0.082791167790369 | -0.125846211231898 | 2.26473467436644e-05 | 0.301400966238008 |
| CER | ADediting_1019404 | chr3_126349536_- | 8.71186169129515e-11 | 0.498237374510827 | 3.48338650420323e-08 | 0.4316671040689 | 0.00417295273703885 | 0.232636621739385 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 0.0614342581384524 | 0.10635730625881 | 0.940719429313844 | 0.00424079871423718 | 4.65987283653435e-55 | 0.740314462851506 |
| AC | 4.54749952421174e-18 | 0.511482804107262 | 7.37159059222547e-09 | 0.35546841456081 | 1.37848010621015e-42 | 0.728257810292443 |
| PCC | 0.390343140075326 | 0.0625042092428397 | 0.816388450174628 | 0.0169106696883679 | 7.91480916483028e-17 | 0.555059716206144 |
| CER | 0.0692893435012797 | 0.148737062008395 | 0.00190218192912737 | 0.251544761111828 | 6.03204734615471e-24 | 0.706088810148266 |
| TCX | 0.627369810228258 | 0.0399537709126202 | 8.20606810004042e-05 | -0.315928394765369 | 2.38300411388421e-22 | 0.68789591769034 |
| FP | 0.0836500064887646 | 0.130025752382951 | 0.952351261360991 | 0.00451053525232058 | 3.17576744695178e-28 | 0.706500534307614 |
| IFG | 0.200666278461544 | 0.264891575081624 | 0.143949978173911 | 0.300829557769297 | 0.00104943761822419 | 0.615778209639137 |
| PG | 0.00329526526919034 | -0.214414101062256 | 4.45946890846536e-07 | -0.360088132587225 | 2.67053840005949e-23 | 0.645425176195528 |
| STG | 0.267164113651592 | 0.12244762668377 | 0.128782052291186 | -0.167064181932609 | 3.0299701071918e-12 | 0.670466585419784 |
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Relation with AD stages for KLF15 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_1019404 | chr3_126349536_- | 5.50203136365475e-05 | 0.377993544270291 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 5.24251483963337e-06 | 0.422501572395945 |
| TCX | 6.90796987284553e-09 | 0.526214745062812 |
| PG | 2.2602949722042e-08 | 0.395745069507777 |
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RelatedDrugs for KLF15 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KLF15 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| KLF15 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| KLF15 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
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