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Differntial gene expression between RNA A-to-I edited versus non-edited samples | |
The effects of the RNA editing to the stability of the RNA structures | |
Gene summary for IGLV1-51 |
Gene summary |
Gene information | Gene symbol | IGLV1-51 | Gene ID | 28820 |
Gene name | immunoglobulin lambda variable 1-51 | |
Synonyms | IGLV151|V1-19 | |
Cytomap | 22q11.22 | |
Type of gene | other | |
Description | Ig lambda chain V-I region 51Ig lambda chain V-I region EPSIg lambda chain V-I region NEWIg lambda chain V-I region NIG-64 | |
Modification date | 20200320 | |
UniProtAcc | P01701, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for IGLV1-51 |
RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
RNA editing frequencies across three data sets. |
The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
RNA A-to-I editing events in AD. |
ADediting_973166(22322800, +), ADediting_973167(22322811, +), ADediting_973168(22322827, +), ADediting_973169(22322830, +), ADediting_973170(22322886, +), |
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RNA editing positional annotations for IGLV1-51 using Annovar |
Protein coding RNA editing(s). |
ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
ADediting_973166 | chr22_22322800_+ | nonsynonymous SNV | ENST00000390290.3 | c.A184G | p.T62A | . | . | . |
ADediting_973167 | chr22_22322811_+ | synonymous SNV | ENST00000390290.3 | c.A195G | p.K65K | . | . | . |
ADediting_973168 | chr22_22322827_+ | nonsynonymous SNV | ENST00000390290.3 | c.A211G | p.N71D | . | . | . |
ADediting_973169 | chr22_22322830_+ | nonsynonymous SNV | ENST00000390290.3 | c.A214G | p.N72D | . | . | . |
ADediting_973170 | chr22_22322886_+ | synonymous SNV | ENST00000390290.3 | c.A270G | p.S90S | . | . | . |
Gene structure information of RNA editing(s). |
ADeditome ID | Position | Variant type |
ADediting_973166 | chr22_22322800_+ | exonic |
ADediting_973167 | chr22_22322811_+ | exonic |
ADediting_973168 | chr22_22322827_+ | exonic |
ADediting_973169 | chr22_22322830_+ | exonic |
ADediting_973170 | chr22_22322886_+ | exonic |
Repat-regional RNA editing(s). |
ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
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RNA A-to-I editing events in the alternative splicing sites for IGLV1-51 |
RNA A-to-I editing(s) in the alternative splicing sites. |
AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for IGLV1-51 |
Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for IGLV1-51 |
- Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for IGLV1-51 |
RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
RNA A-to-I editing in lncRNA gained miRNA binding sites. |
ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
RNA A-to-I editing in lncRNA lost miRNA binding sites. |
ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
RNA A-to-I editing in miRNAs gained binding to lncRNA. |
ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
RNA A-to-I editing in miRNAs lost binding to lncRNA. |
ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for IGLV1-51 |
- RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
RNA A-to-I editing in miRNA. |
ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
RNA A-to-I editing in mRNA. |
ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
RNA A-to-I editing in lncRNA. |
ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for IGLV1-51 |
Correlation between ADAR gene expression and RNA editing frequency |
Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
Correlation between ADAR gene expression and this gene's expression |
Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with AD stages for IGLV1-51 |
Correlation between AD stages and RNA editing frequency |
Tissue | ADeditomID | position | P-val | Coeff. |
Correlation between AD stages and this gene's expression |
Tissue | P-val | Coeff. |
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RelatedDrugs for IGLV1-51 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IGLV1-51 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |