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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for F11-AS1

check button Gene summary
Gene informationGene symbol

F11-AS1

Gene ID

285441

Gene nameF11 antisense RNA 1
Synonyms-
Cytomap

4q35.2

Type of genencRNA
Description-
Modification date20200313
UniProtAcc

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for F11-AS1

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1120382(186294922, -), ADediting_1120383(186323675, -), ADediting_1120384(186346239, -), ADediting_1120385(186346458, -), ADediting_1120386(186379945, -), ADediting_1120387(186406774, -), ADediting_1120388(186412987, -), ADediting_1120389(186413024, -), ADediting_1120390(186413085, -), ADediting_1120391(186413094, -), ADediting_1120392(186413095, -), ADediting_1120393(186413117, -), ADediting_1120394(186413147, -), ADediting_1120395(186413171, -), ADediting_1120396(186415649, -), ADediting_1120397(186415650, -), ADediting_1120398(186415712, -), ADediting_1120399(186415727, -), ADediting_1120400(186415730, -), ADediting_1120401(186415769, -), ADediting_1120402(186415779, -), ADediting_1120403(186415782, -), ADediting_1120404(186415783, -), ADediting_1120405(186415791, -), ADediting_1120406(186415808, -), ADediting_1120407(186415809, -), ADediting_1120408(186415839, -), ADediting_1120409(186415877, -), ADediting_1120410(186415889, -), ADediting_1120411(186418509, -), ADediting_1120412(186418521, -), ADediting_1120413(186418548, -), ADediting_1120414(186421533, -), ADediting_1120415(186421540, -), ADediting_1120416(186421543, -), ADediting_1120417(186421567, -), ADediting_1120418(186421631, -), ADediting_1120419(186421891, -), ADediting_1120420(186421906, -), ADediting_1120421(186421936, -), ADediting_1120422(186421953, -), ADediting_1120423(186421959, -), ADediting_1120424(186421999, -), ADediting_1120425(186422006, -), ADediting_1120426(186422017, -), ADediting_1120427(186422071, -), ADediting_1120428(186423237, -), ADediting_1120429(186423290, -), ADediting_1120430(186426123, -), ADediting_1120431(186443191, -), ADediting_1120432(186447013, -), ADediting_1120433(186447052, -), ADediting_1120434(186447089, -), ADediting_1120435(186447096, -), ADediting_1120436(186459345, -), ADediting_1120437(186459351, -), ADediting_1120438(186473811, -), ADediting_1120439(186474973, -), ADediting_1120440(186474993, -), ADediting_1120441(186474995, -), ADediting_1120442(186474998, -), ADediting_1120443(186475004, -), ADediting_1120444(186475039, -), ADediting_1120445(186475049, -), ADediting_1120446(186475053, -), ADediting_1120447(186475109, -), ADediting_1120448(186475674, -), ADediting_1120449(186476268, -), ADediting_1120450(186483206, -), ADediting_1120451(186483207, -), ADediting_1120452(186483209, -), ADediting_1120453(186483219, -), ADediting_1120454(186483248, -), ADediting_1120455(186483269, -), ADediting_1120456(186484476, -), ADediting_1120457(186484477, -),

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RNA editing positional annotations for F11-AS1 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1120382chr4_186294922_-ncRNA_intronic
ADediting_1120383chr4_186323675_-ncRNA_intronic
ADediting_1120384chr4_186346239_-ncRNA_intronic
ADediting_1120385chr4_186346458_-ncRNA_intronic
ADediting_1120386chr4_186379945_-ncRNA_intronic
ADediting_1120387chr4_186406774_-ncRNA_intronic
ADediting_1120388chr4_186412987_-ncRNA_intronic
ADediting_1120389chr4_186413024_-ncRNA_intronic
ADediting_1120390chr4_186413085_-ncRNA_intronic
ADediting_1120391chr4_186413094_-ncRNA_intronic
ADediting_1120392chr4_186413095_-ncRNA_intronic
ADediting_1120393chr4_186413117_-ncRNA_intronic
ADediting_1120394chr4_186413147_-ncRNA_intronic
ADediting_1120395chr4_186413171_-ncRNA_intronic
ADediting_1120396chr4_186415649_-ncRNA_intronic
ADediting_1120397chr4_186415650_-ncRNA_intronic
ADediting_1120398chr4_186415712_-ncRNA_intronic
ADediting_1120399chr4_186415727_-ncRNA_intronic
ADediting_1120400chr4_186415730_-ncRNA_intronic
ADediting_1120401chr4_186415769_-ncRNA_intronic
ADediting_1120402chr4_186415779_-ncRNA_intronic
ADediting_1120403chr4_186415782_-ncRNA_intronic
ADediting_1120404chr4_186415783_-ncRNA_intronic
ADediting_1120405chr4_186415791_-ncRNA_intronic
ADediting_1120406chr4_186415808_-ncRNA_intronic
ADediting_1120407chr4_186415809_-ncRNA_intronic
ADediting_1120408chr4_186415839_-ncRNA_intronic
ADediting_1120409chr4_186415877_-ncRNA_intronic
ADediting_1120410chr4_186415889_-ncRNA_intronic
ADediting_1120411chr4_186418509_-ncRNA_intronic
ADediting_1120412chr4_186418521_-ncRNA_intronic
ADediting_1120413chr4_186418548_-ncRNA_intronic
ADediting_1120414chr4_186421533_-ncRNA_intronic
ADediting_1120415chr4_186421540_-ncRNA_intronic
ADediting_1120416chr4_186421543_-ncRNA_intronic
ADediting_1120417chr4_186421567_-ncRNA_intronic
ADediting_1120418chr4_186421631_-ncRNA_intronic
ADediting_1120419chr4_186421891_-ncRNA_intronic
ADediting_1120420chr4_186421906_-ncRNA_intronic
ADediting_1120421chr4_186421936_-ncRNA_intronic
ADediting_1120422chr4_186421953_-ncRNA_intronic
ADediting_1120423chr4_186421959_-ncRNA_intronic
ADediting_1120424chr4_186421999_-ncRNA_intronic
ADediting_1120425chr4_186422006_-ncRNA_intronic
ADediting_1120426chr4_186422017_-ncRNA_intronic
ADediting_1120427chr4_186422071_-ncRNA_intronic
ADediting_1120428chr4_186423237_-ncRNA_intronic
ADediting_1120429chr4_186423290_-ncRNA_intronic
ADediting_1120430chr4_186426123_-ncRNA_intronic
ADediting_1120431chr4_186443191_-ncRNA_intronic
ADediting_1120432chr4_186447013_-ncRNA_intronic
ADediting_1120433chr4_186447052_-ncRNA_intronic
ADediting_1120434chr4_186447089_-ncRNA_intronic
ADediting_1120435chr4_186447096_-ncRNA_intronic
ADediting_1120436chr4_186459345_-ncRNA_intronic
ADediting_1120437chr4_186459351_-ncRNA_intronic
ADediting_1120438chr4_186473811_-ncRNA_intronic
ADediting_1120439chr4_186474973_-ncRNA_intronic
ADediting_1120440chr4_186474993_-ncRNA_intronic
ADediting_1120441chr4_186474995_-ncRNA_intronic
ADediting_1120442chr4_186474998_-ncRNA_intronic
ADediting_1120443chr4_186475004_-ncRNA_intronic
ADediting_1120444chr4_186475039_-ncRNA_intronic
ADediting_1120445chr4_186475049_-ncRNA_intronic
ADediting_1120446chr4_186475053_-ncRNA_intronic
ADediting_1120447chr4_186475109_-ncRNA_intronic
ADediting_1120448chr4_186475674_-ncRNA_intronic
ADediting_1120449chr4_186476268_-ncRNA_intronic
ADediting_1120450chr4_186483206_-ncRNA_intronic
ADediting_1120451chr4_186483207_-ncRNA_intronic
ADediting_1120452chr4_186483209_-ncRNA_intronic
ADediting_1120453chr4_186483219_-ncRNA_intronic
ADediting_1120454chr4_186483248_-ncRNA_intronic
ADediting_1120455chr4_186483269_-ncRNA_intronic
ADediting_1120456chr4_186484476_-ncRNA_intronic
ADediting_1120457chr4_186484477_-ncRNA_intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1120382chr4_186294922_-SINEAluName=AluSc
ADediting_1120383chr4_186323675_-SINEAluName=AluSg
ADediting_1120384chr4_186346239_-SINEAluName=AluSx1
ADediting_1120385chr4_186346458_-SINEAluName=AluSx1
ADediting_1120386chr4_186379945_-SINEAluName=AluSc8
ADediting_1120387chr4_186406774_-SINEAluName=AluSx1
ADediting_1120388chr4_186412987_-SINEAluName=AluY
ADediting_1120389chr4_186413024_-SINEAluName=AluY
ADediting_1120390chr4_186413085_-SINEAluName=AluY
ADediting_1120391chr4_186413094_-SINEAluName=AluY
ADediting_1120392chr4_186413095_-SINEAluName=AluY
ADediting_1120393chr4_186413117_-SINEAluName=AluY
ADediting_1120394chr4_186413147_-SINEAluName=AluY
ADediting_1120395chr4_186413171_-SINEAluName=AluY
ADediting_1120396chr4_186415649_-SINEAluName=AluSz
ADediting_1120397chr4_186415650_-SINEAluName=AluSz
ADediting_1120398chr4_186415712_-SINEAluName=AluSz
ADediting_1120399chr4_186415727_-SINEAluName=AluSz
ADediting_1120400chr4_186415730_-SINEAluName=AluSz
ADediting_1120401chr4_186415769_-SINEAluName=AluSz
ADediting_1120402chr4_186415779_-SINEAluName=AluSz
ADediting_1120403chr4_186415782_-SINEAluName=AluSz
ADediting_1120404chr4_186415783_-SINEAluName=AluSz
ADediting_1120405chr4_186415791_-SINEAluName=AluSz
ADediting_1120406chr4_186415808_-SINEAluName=AluSz
ADediting_1120407chr4_186415809_-SINEAluName=AluSz
ADediting_1120408chr4_186415839_-SINEAluName=AluSz
ADediting_1120409chr4_186415877_-SINEAluName=AluSz
ADediting_1120410chr4_186415889_-SINEAluName=AluSz
ADediting_1120411chr4_186418509_-SINEAluName=AluSq2
ADediting_1120412chr4_186418521_-SINEAluName=AluSq2
ADediting_1120413chr4_186418548_-SINEAluName=AluSq2
ADediting_1120414chr4_186421533_-SINEAluName=AluJb
ADediting_1120415chr4_186421540_-SINEAluName=AluJb
ADediting_1120416chr4_186421543_-SINEAluName=AluJb
ADediting_1120417chr4_186421567_-SINEAluName=AluJb
ADediting_1120418chr4_186421631_-SINEAluName=AluJb
ADediting_1120419chr4_186421891_-SINEAluName=AluSx1
ADediting_1120420chr4_186421906_-SINEAluName=AluSx1
ADediting_1120421chr4_186421936_-SINEAluName=AluSx1
ADediting_1120422chr4_186421953_-SINEAluName=AluSx1
ADediting_1120423chr4_186421959_-SINEAluName=AluSx1
ADediting_1120424chr4_186421999_-SINEAluName=AluSx1
ADediting_1120425chr4_186422006_-SINEAluName=AluSx1
ADediting_1120426chr4_186422017_-SINEAluName=AluSx1
ADediting_1120427chr4_186422071_-SINEAluName=AluSx1
ADediting_1120428chr4_186423237_-SINEAluName=AluSg
ADediting_1120429chr4_186423290_-SINEAluName=AluSg
ADediting_1120430chr4_186426123_-SINEAluName=AluY
ADediting_1120431chr4_186443191_-SINEAluName=AluSp
ADediting_1120432chr4_186447013_-SINEAluName=AluSp
ADediting_1120433chr4_186447052_-SINEAluName=AluSp
ADediting_1120434chr4_186447089_-SINEAluName=AluSp
ADediting_1120435chr4_186447096_-SINEAluName=AluSp
ADediting_1120436chr4_186459345_-SINEAluName=AluJb
ADediting_1120437chr4_186459351_-SINEAluName=AluJb
ADediting_1120438chr4_186473811_-SINEAluName=AluSz
ADediting_1120439chr4_186474973_-SINEAluName=AluSz
ADediting_1120440chr4_186474993_-SINEAluName=AluSz
ADediting_1120441chr4_186474995_-SINEAluName=AluSz
ADediting_1120442chr4_186474998_-SINEAluName=AluSz
ADediting_1120443chr4_186475004_-SINEAluName=AluSz
ADediting_1120444chr4_186475039_-SINEAluName=AluSz
ADediting_1120445chr4_186475049_-SINEAluName=AluSz
ADediting_1120446chr4_186475053_-SINEAluName=AluSz
ADediting_1120447chr4_186475109_-SINEAluName=AluSz
ADediting_1120448chr4_186475674_-SINEAluName=AluSp
ADediting_1120449chr4_186476268_-SINEAluName=AluSc8
ADediting_1120450chr4_186483206_-SINEAluName=AluSx3
ADediting_1120451chr4_186483207_-SINEAluName=AluSx3
ADediting_1120452chr4_186483209_-SINEAluName=AluSx3
ADediting_1120453chr4_186483219_-SINEAluName=AluSx3
ADediting_1120454chr4_186483248_-SINEAluName=AluSx3
ADediting_1120455chr4_186483269_-SINEAluName=AluSx3
ADediting_1120456chr4_186484476_-SINEAluName=AluSc
ADediting_1120457chr4_186484477_-SINEAluName=AluSc

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RNA A-to-I editing events in the alternative splicing sites for F11-AS1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for F11-AS1

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for F11-AS1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for F11-AS1


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1391023chr8_140732605_-ENSG00000251165.6ENST00000505103.5F11-AS1-201hsa-miR-151a-3pchr41862885801862885867mer-m8186288579186288597148-14.55
ADediting_1471004chr9_63819627_+ENSG00000251165.6ENST00000505103.5F11-AS1-201hsa-miR-4477bchr41862861241862861318mer-1a186286124186286143149-15.02
ADediting_1556067chr19_40282625_-ENSG00000251165.6ENST00000657917.1F11-AS1-205hsa-miR-641chr41864877281864877347mer-m8186487727186487750145-16.41
ADediting_286380chr11_79422188_-ENSG00000251165.6ENST00000508110.5F11-AS1-202hsa-miR-5579-3pchr41864266431864266508mer-1a186426643186426666143-13.99
ADediting_843620chr2_207754818_+ENSG00000251165.6ENST00000508110.5F11-AS1-202hsa-miR-4775chr41864267401864267467mer-m8186426739186426763159-12.37
ADediting_98289chr1_32086992_+ENSG00000251165.6ENST00000505103.5F11-AS1-201hsa-miR-5585-3pchr41862886121862886187mer-m8186288611186288632142-15.01

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000251165.6ENST00000505103.5F11-AS1-201hsa-miR-5688chr41862887541862887607mer-m8186288753186288774144-10.85
ADediting_527135chr16_24203190_+ENSG00000251165.6ENST00000508110.5F11-AS1-202hsa-miR-1273h-3pchr41864262951864263028mer-1a186426295186426316140-11.81
ADediting_843620chr2_207754818_+ENSG00000251165.6ENST00000657917.1F11-AS1-205hsa-miR-4775chr41863782721863782798mer-1a186378272186378292152-5.19
ADediting_98288chr1_32086990_+ENSG00000251165.6ENST00000508287.1F11-AS1-203hsa-miR-5585-3pchr41864288061864288138mer-1a186428806186428827142-9.65
ADediting_98289chr1_32086992_+ENSG00000251165.6ENST00000508287.1F11-AS1-203hsa-miR-5585-3pchr41864288061864288138mer-1a186428806186428827142-9.65

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for F11-AS1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for F11-AS1

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_1120392chr4_186413095_-0.0260901568400456-0.1263674827012130.000340522254171637-0.202175275609452.95389811881926e-080.308422865635512
DLPFCADediting_1120410chr4_186415889_-0.840998175122669-0.01144011429352280.0979043614196584-0.09417474129523758.97560442989794e-090.319229815581588
DLPFCADediting_1120415chr4_186421540_-0.3374375134427270.05466128591415590.253198303715495-0.06509030289947639.29389904017041e-170.44865006331634
DLPFCADediting_1120417chr4_186421567_-0.0420639719832135-0.1155400097730340.000514451264877208-0.1961328083164584.60058594060603e-090.325110122880879
DLPFCADediting_1120419chr4_186421891_-0.366240711417651-0.05149144206080730.011024956634829-0.1441978476318554.31404731371572e-110.363062495038338
DLPFCADediting_1120420chr4_186421906_-0.10076041099948-0.09338612019154420.00529513590325278-0.1580187667905092.37015657729384e-090.330823830146682
DLPFCADediting_1120421chr4_186421936_-0.350499492280717-0.05320346669949970.068861992587645-0.103471150895351.27595295216804e-080.316083119115645
DLPFCADediting_1120429chr4_186423290_-0.1427729771656420.083429076160630.70945607456167-0.02124493818278643.43367939237066e-170.4542819968431

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
AC2.25632046953673e-050.2645623066597270.2405049162093780.07450309308689312.27002814022163e-140.458045906507242
PCC0.00494314973494160.2025927931385880.03241080873197610.1548762376108961.42041284415747e-050.308414578771564
FP0.003003504017341130.2212108445237460.004904551413190680.2099842841693944.66837058313389e-050.300226940502163
IFG0.06448640924586270.3753254500649450.005940855261359870.5342542594653510.289706641717870.220419440091678
PG5.53796475880629e-100.4349188260270835.46522737237988e-050.2913643132631230.4817882641362240.0518929982955193
STG0.03532286673144880.2299929142521090.2713807101732140.1213820673800390.0006582240397338750.36427145925838

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Relation with AD stages for F11-AS1

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
TCX0.0001105691044154370.36669313697632

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RelatedDrugs for F11-AS1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for F11-AS1

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource