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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for GNAI2 |
 Gene summary |
| Gene information | Gene symbol | GNAI2 | Gene ID | 2771 |
| Gene name | G protein subunit alpha i2 | |
| Synonyms | GIP|GNAI2B|H_LUCA15.1|H_LUCA16.1 | |
| Cytomap | 3p21.31 | |
| Type of gene | protein-coding | |
| Description | guanine nucleotide-binding protein G(i) subunit alpha-2GTP-binding regulatory protein Gi alpha-2 chainadenylate cyclase-inhibiting G alpha proteinguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2guanine nucleotide | |
| Modification date | 20200313 | |
| UniProtAcc | P04899, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for GNAI2 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1079543(50226812, +), ADediting_1079544(50226820, +), ADediting_1079545(50228283, +), ADediting_1079546(50228297, +), ADediting_1079547(50228366, +), ADediting_1079548(50228390, +), ADediting_1079549(50228433, +), ADediting_1079550(50228438, +), ADediting_1079551(50228484, +), ADediting_1079552(50228495, +), ADediting_1079553(50228499, +), ADediting_1079554(50228500, +), ADediting_1079555(50231335, +), ADediting_1079556(50231348, +), ADediting_1079557(50231359, +), ADediting_1079558(50231378, +), ADediting_1079559(50231379, +), ADediting_1079560(50231396, +), ADediting_1079561(50231408, +), ADediting_1079562(50231418, +), ADediting_1079563(50231440, +), ADediting_1079564(50231459, +), ADediting_1079565(50231462, +), ADediting_1079566(50231476, +), ADediting_1079567(50231522, +), ADediting_1079568(50231527, +), ADediting_1079569(50231536, +), ADediting_1079570(50231549, +), ADediting_1079571(50231919, +), ADediting_1079572(50231963, +), ADediting_1079573(50232075, +), ADediting_1079574(50232076, +), ADediting_1079575(50232165, +), ADediting_1079576(50232168, +), ADediting_1079577(50232245, +), ADediting_1079578(50232251, +), ADediting_1079579(50232255, +), ADediting_1079580(50232279, +), ADediting_1079581(50232280, +), ADediting_1079582(50233965, +), ADediting_1079583(50235423, +), ADediting_1079584(50237123, +), ADediting_1079585(50240848, +), ADediting_1079586(50240858, +), ADediting_1079587(50240906, +), ADediting_1079588(50240936, +), ADediting_1079589(50241544, +), ADediting_1079590(50242433, +), ADediting_1079591(50245047, +), ADediting_1079592(50245138, +), ADediting_1079593(50245245, +), ADediting_1079594(50248114, +), ADediting_1079595(50248166, +), ADediting_1079596(50248185, +), ADediting_1079597(50248194, +), ADediting_1079598(50248202, +), ADediting_1079599(50248218, +), ADediting_1079600(50250975, +), ADediting_1575079(50228391, +), ADediting_1575080(50228394, +), ADediting_1575081(50231353, +), ADediting_1575082(50231424, +), ADediting_1575083(50231453, +), ADediting_1575084(50231493, +), ADediting_1575085(50231567, +), ADediting_1575086(50231942, +), ADediting_1575087(50231964, +), ADediting_1575088(50232039, +), ADediting_1575089(50232040, +), ADediting_1575090(50232044, +), ADediting_1575091(50232046, +), ADediting_1575092(50233951, +), ADediting_1575093(50233970, +), ADediting_1575094(50233989, +), ADediting_1575095(50234025, +), ADediting_1575096(50234026, +), ADediting_1575097(50234029, +), ADediting_1575098(50234035, +), ADediting_1575099(50234041, +), ADediting_1575100(50234206, +), ADediting_1575101(50234267, +), ADediting_1575102(50234322, +), ADediting_1575103(50234331, +), ADediting_1575104(50234532, +), ADediting_1575105(50234541, +), ADediting_1575106(50234604, +), ADediting_1575107(50235469, +), ADediting_1575108(50248141, +), ADediting_1575109(50248186, +), |
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RNA editing positional annotations for GNAI2 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1079543 | chr3_50226812_+ | UTR5 |
| ADediting_1079544 | chr3_50226820_+ | UTR5 |
| ADediting_1079545 | chr3_50228283_+ | intronic |
| ADediting_1079546 | chr3_50228297_+ | intronic |
| ADediting_1079547 | chr3_50228366_+ | intronic |
| ADediting_1079548 | chr3_50228390_+ | intronic |
| ADediting_1079549 | chr3_50228433_+ | intronic |
| ADediting_1079550 | chr3_50228438_+ | intronic |
| ADediting_1079551 | chr3_50228484_+ | intronic |
| ADediting_1079552 | chr3_50228495_+ | intronic |
| ADediting_1079553 | chr3_50228499_+ | intronic |
| ADediting_1079554 | chr3_50228500_+ | intronic |
| ADediting_1079555 | chr3_50231335_+ | intronic |
| ADediting_1079556 | chr3_50231348_+ | intronic |
| ADediting_1079557 | chr3_50231359_+ | intronic |
| ADediting_1079558 | chr3_50231378_+ | intronic |
| ADediting_1079559 | chr3_50231379_+ | intronic |
| ADediting_1079560 | chr3_50231396_+ | intronic |
| ADediting_1079561 | chr3_50231408_+ | intronic |
| ADediting_1079562 | chr3_50231418_+ | intronic |
| ADediting_1079563 | chr3_50231440_+ | intronic |
| ADediting_1079564 | chr3_50231459_+ | intronic |
| ADediting_1079565 | chr3_50231462_+ | intronic |
| ADediting_1079566 | chr3_50231476_+ | intronic |
| ADediting_1079567 | chr3_50231522_+ | intronic |
| ADediting_1079568 | chr3_50231527_+ | intronic |
| ADediting_1079569 | chr3_50231536_+ | intronic |
| ADediting_1079570 | chr3_50231549_+ | intronic |
| ADediting_1079571 | chr3_50231919_+ | intronic |
| ADediting_1079572 | chr3_50231963_+ | intronic |
| ADediting_1079573 | chr3_50232075_+ | intronic |
| ADediting_1079574 | chr3_50232076_+ | intronic |
| ADediting_1079575 | chr3_50232165_+ | intronic |
| ADediting_1079576 | chr3_50232168_+ | intronic |
| ADediting_1079577 | chr3_50232245_+ | intronic |
| ADediting_1079578 | chr3_50232251_+ | intronic |
| ADediting_1079579 | chr3_50232255_+ | intronic |
| ADediting_1079580 | chr3_50232279_+ | intronic |
| ADediting_1079581 | chr3_50232280_+ | intronic |
| ADediting_1079582 | chr3_50233965_+ | intronic |
| ADediting_1079583 | chr3_50235423_+ | intronic |
| ADediting_1079584 | chr3_50237123_+ | intronic |
| ADediting_1079585 | chr3_50240848_+ | intronic |
| ADediting_1079586 | chr3_50240858_+ | intronic |
| ADediting_1079587 | chr3_50240906_+ | intronic |
| ADediting_1079588 | chr3_50240936_+ | intronic |
| ADediting_1079589 | chr3_50241544_+ | intronic |
| ADediting_1079590 | chr3_50242433_+ | intronic |
| ADediting_1079591 | chr3_50245047_+ | intronic |
| ADediting_1079592 | chr3_50245138_+ | intronic |
| ADediting_1079593 | chr3_50245245_+ | intronic |
| ADediting_1079594 | chr3_50248114_+ | intronic |
| ADediting_1079595 | chr3_50248166_+ | intronic |
| ADediting_1079596 | chr3_50248185_+ | intronic |
| ADediting_1079597 | chr3_50248194_+ | intronic |
| ADediting_1079598 | chr3_50248202_+ | intronic |
| ADediting_1079599 | chr3_50248218_+ | intronic |
| ADediting_1079600 | chr3_50250975_+ | intronic |
| ADediting_1575079 | chr3_50228391_+ | intronic |
| ADediting_1575080 | chr3_50228394_+ | intronic |
| ADediting_1575081 | chr3_50231353_+ | intronic |
| ADediting_1575082 | chr3_50231424_+ | intronic |
| ADediting_1575083 | chr3_50231453_+ | intronic |
| ADediting_1575084 | chr3_50231493_+ | intronic |
| ADediting_1575085 | chr3_50231567_+ | intronic |
| ADediting_1575086 | chr3_50231942_+ | intronic |
| ADediting_1575087 | chr3_50231964_+ | intronic |
| ADediting_1575088 | chr3_50232039_+ | intronic |
| ADediting_1575089 | chr3_50232040_+ | intronic |
| ADediting_1575090 | chr3_50232044_+ | intronic |
| ADediting_1575091 | chr3_50232046_+ | intronic |
| ADediting_1575092 | chr3_50233951_+ | intronic |
| ADediting_1575093 | chr3_50233970_+ | intronic |
| ADediting_1575094 | chr3_50233989_+ | intronic |
| ADediting_1575095 | chr3_50234025_+ | intronic |
| ADediting_1575096 | chr3_50234026_+ | intronic |
| ADediting_1575097 | chr3_50234029_+ | intronic |
| ADediting_1575098 | chr3_50234035_+ | intronic |
| ADediting_1575099 | chr3_50234041_+ | intronic |
| ADediting_1575100 | chr3_50234206_+ | intronic |
| ADediting_1575101 | chr3_50234267_+ | intronic |
| ADediting_1575102 | chr3_50234322_+ | intronic |
| ADediting_1575103 | chr3_50234331_+ | intronic |
| ADediting_1575104 | chr3_50234532_+ | intronic |
| ADediting_1575105 | chr3_50234541_+ | intronic |
| ADediting_1575106 | chr3_50234604_+ | intronic |
| ADediting_1575107 | chr3_50235469_+ | intronic |
| ADediting_1575108 | chr3_50248141_+ | intronic |
| ADediting_1575109 | chr3_50248186_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1079543 | chr3_50226812_+ | SINE | Alu | Name=AluYk2 |
| ADediting_1079544 | chr3_50226820_+ | SINE | Alu | Name=AluYk2 |
| ADediting_1079545 | chr3_50228283_+ | SINE | Alu | Name=AluSx |
| ADediting_1079546 | chr3_50228297_+ | SINE | Alu | Name=AluSx |
| ADediting_1079547 | chr3_50228366_+ | SINE | Alu | Name=AluSx |
| ADediting_1079548 | chr3_50228390_+ | SINE | Alu | Name=AluSx |
| ADediting_1079549 | chr3_50228433_+ | SINE | Alu | Name=AluSx |
| ADediting_1079550 | chr3_50228438_+ | SINE | Alu | Name=AluSx |
| ADediting_1079551 | chr3_50228484_+ | SINE | Alu | Name=AluSx |
| ADediting_1079552 | chr3_50228495_+ | SINE | Alu | Name=AluSx |
| ADediting_1079553 | chr3_50228499_+ | SINE | Alu | Name=AluSx |
| ADediting_1079554 | chr3_50228500_+ | SINE | Alu | Name=AluSx |
| ADediting_1079555 | chr3_50231335_+ | SINE | Alu | Name=AluSc |
| ADediting_1079556 | chr3_50231348_+ | SINE | Alu | Name=AluSc |
| ADediting_1079557 | chr3_50231359_+ | SINE | Alu | Name=AluSc |
| ADediting_1079558 | chr3_50231378_+ | SINE | Alu | Name=AluSc |
| ADediting_1079559 | chr3_50231379_+ | SINE | Alu | Name=AluSc |
| ADediting_1079560 | chr3_50231396_+ | SINE | Alu | Name=AluSc |
| ADediting_1079561 | chr3_50231408_+ | SINE | Alu | Name=AluSc |
| ADediting_1079562 | chr3_50231418_+ | SINE | Alu | Name=AluSc |
| ADediting_1079563 | chr3_50231440_+ | SINE | Alu | Name=AluSc |
| ADediting_1079564 | chr3_50231459_+ | SINE | Alu | Name=AluSc |
| ADediting_1079565 | chr3_50231462_+ | SINE | Alu | Name=AluSc |
| ADediting_1079566 | chr3_50231476_+ | SINE | Alu | Name=AluSc |
| ADediting_1079567 | chr3_50231522_+ | SINE | Alu | Name=AluSc |
| ADediting_1079568 | chr3_50231527_+ | SINE | Alu | Name=AluSc |
| ADediting_1079569 | chr3_50231536_+ | SINE | Alu | Name=AluSc |
| ADediting_1079570 | chr3_50231549_+ | SINE | Alu | Name=AluSc |
| ADediting_1079571 | chr3_50231919_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1079572 | chr3_50231963_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1079573 | chr3_50232075_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1079574 | chr3_50232076_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1079575 | chr3_50232165_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1079576 | chr3_50232168_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1079577 | chr3_50232245_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1079578 | chr3_50232251_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1079579 | chr3_50232255_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1079580 | chr3_50232279_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1079581 | chr3_50232280_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1079582 | chr3_50233965_+ | SINE | Alu | Name=AluSx |
| ADediting_1079583 | chr3_50235423_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1079585 | chr3_50240848_+ | SINE | Alu | Name=AluSx |
| ADediting_1079586 | chr3_50240858_+ | SINE | Alu | Name=AluSx |
| ADediting_1079587 | chr3_50240906_+ | SINE | Alu | Name=AluSx |
| ADediting_1079588 | chr3_50240936_+ | SINE | Alu | Name=AluSx |
| ADediting_1079591 | chr3_50245047_+ | SINE | Alu | Name=AluSp |
| ADediting_1079592 | chr3_50245138_+ | SINE | Alu | Name=AluSp |
| ADediting_1079593 | chr3_50245245_+ | SINE | Alu | Name=AluSp |
| ADediting_1079594 | chr3_50248114_+ | SINE | Alu | Name=AluSz |
| ADediting_1079595 | chr3_50248166_+ | SINE | Alu | Name=AluSz |
| ADediting_1079596 | chr3_50248185_+ | SINE | Alu | Name=AluSz |
| ADediting_1079597 | chr3_50248194_+ | SINE | Alu | Name=AluSz |
| ADediting_1079598 | chr3_50248202_+ | SINE | Alu | Name=AluSz |
| ADediting_1079599 | chr3_50248218_+ | SINE | Alu | Name=AluSz |
| ADediting_1079600 | chr3_50250975_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1575079 | chr3_50228391_+ | SINE | Alu | Name=AluSx |
| ADediting_1575080 | chr3_50228394_+ | SINE | Alu | Name=AluSx |
| ADediting_1575081 | chr3_50231353_+ | SINE | Alu | Name=AluSc |
| ADediting_1575082 | chr3_50231424_+ | SINE | Alu | Name=AluSc |
| ADediting_1575083 | chr3_50231453_+ | SINE | Alu | Name=AluSc |
| ADediting_1575084 | chr3_50231493_+ | SINE | Alu | Name=AluSc |
| ADediting_1575085 | chr3_50231567_+ | SINE | Alu | Name=AluSc |
| ADediting_1575086 | chr3_50231942_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1575087 | chr3_50231964_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1575088 | chr3_50232039_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1575089 | chr3_50232040_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1575090 | chr3_50232044_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1575091 | chr3_50232046_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1575092 | chr3_50233951_+ | SINE | Alu | Name=AluSx |
| ADediting_1575093 | chr3_50233970_+ | SINE | Alu | Name=AluSx |
| ADediting_1575094 | chr3_50233989_+ | SINE | Alu | Name=AluSx |
| ADediting_1575095 | chr3_50234025_+ | SINE | Alu | Name=AluSx |
| ADediting_1575096 | chr3_50234026_+ | SINE | Alu | Name=AluSx |
| ADediting_1575097 | chr3_50234029_+ | SINE | Alu | Name=AluSx |
| ADediting_1575098 | chr3_50234035_+ | SINE | Alu | Name=AluSx |
| ADediting_1575099 | chr3_50234041_+ | SINE | Alu | Name=AluSx |
| ADediting_1575100 | chr3_50234206_+ | SINE | Alu | Name=AluY |
| ADediting_1575101 | chr3_50234267_+ | SINE | Alu | Name=AluY |
| ADediting_1575102 | chr3_50234322_+ | SINE | Alu | Name=AluY |
| ADediting_1575103 | chr3_50234331_+ | SINE | Alu | Name=AluY |
| ADediting_1575104 | chr3_50234532_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1575105 | chr3_50234541_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1575106 | chr3_50234604_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1575107 | chr3_50235469_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1575108 | chr3_50248141_+ | SINE | Alu | Name=AluSz |
| ADediting_1575109 | chr3_50248186_+ | SINE | Alu | Name=AluSz |
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RNA A-to-I editing events in the alternative splicing sites for GNAI2 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GNAI2 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |