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Center for Computational Systems Medicine
Soverview

Gene summary

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RNA A-to-I events

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Differntial gene expression between RNA A-to-I edited versus non-edited samples

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Protein coding region RNA A-to-I editings

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The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

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Relation with ADAR

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Relation with AD stages

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Related drugs with this gene

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Related diseases with this gene


Gene summary for GM2A

check button Gene summary
Gene informationGene symbol

GM2A

Gene ID

2760

Gene nameGM2 ganglioside activator
SynonymsGM2-AP|SAP-3
Cytomap

5q33.1

Type of geneprotein-coding
Descriptionganglioside GM2 activatorcerebroside sulfate activator proteinshingolipid activator protein 3sphingolipid activator protein 3
Modification date20200313
UniProtAcc

P17900,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for GM2A

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1181227(151268176, +), ADediting_1181228(151268178, +), ADediting_1181229(151268180, +), ADediting_1181230(151268183, +), ADediting_1181231(151268188, +), ADediting_1181232(151268220, +), ADediting_1181233(151268236, +), ADediting_1181234(151268255, +), ADediting_1181235(151268256, +), ADediting_1181236(151268259, +), ADediting_1181237(151268260, +), ADediting_1181238(151268273, +), ADediting_1181239(151268282, +), ADediting_1181240(151268285, +), ADediting_1181241(151268295, +), ADediting_1181242(151268320, +), ADediting_1181243(151268329, +), ADediting_1181244(151268335, +), ADediting_1181245(151268338, +), ADediting_1181246(151268352, +), ADediting_1181247(151268355, +), ADediting_1181248(151268364, +), ADediting_1181249(151268400, +), ADediting_1181250(151268414, +), ADediting_1181251(151268415, +), ADediting_1181252(151268426, +), ADediting_1181253(151268432, +), ADediting_1181254(151268435, +), ADediting_1181255(151268442, +), ADediting_1181256(151268584, +), ADediting_1655541(151268281, +),

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RNA editing positional annotations for GM2A using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1181227chr5_151268176_+UTR3
ADediting_1181228chr5_151268178_+UTR3
ADediting_1181229chr5_151268180_+UTR3
ADediting_1181230chr5_151268183_+UTR3
ADediting_1181231chr5_151268188_+UTR3
ADediting_1181232chr5_151268220_+UTR3
ADediting_1181233chr5_151268236_+UTR3
ADediting_1181234chr5_151268255_+UTR3
ADediting_1181235chr5_151268256_+UTR3
ADediting_1181236chr5_151268259_+UTR3
ADediting_1181237chr5_151268260_+UTR3
ADediting_1181238chr5_151268273_+UTR3
ADediting_1181239chr5_151268282_+UTR3
ADediting_1181240chr5_151268285_+UTR3
ADediting_1181241chr5_151268295_+UTR3
ADediting_1181242chr5_151268320_+UTR3
ADediting_1181243chr5_151268329_+UTR3
ADediting_1181244chr5_151268335_+UTR3
ADediting_1181245chr5_151268338_+UTR3
ADediting_1181246chr5_151268352_+UTR3
ADediting_1181247chr5_151268355_+UTR3
ADediting_1181248chr5_151268364_+UTR3
ADediting_1181249chr5_151268400_+UTR3
ADediting_1181250chr5_151268414_+UTR3
ADediting_1181251chr5_151268415_+UTR3
ADediting_1181252chr5_151268426_+UTR3
ADediting_1181253chr5_151268432_+UTR3
ADediting_1181254chr5_151268435_+UTR3
ADediting_1181255chr5_151268442_+UTR3
ADediting_1181256chr5_151268584_+UTR3
ADediting_1655541chr5_151268281_+UTR3

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1181227chr5_151268176_+SINEAluName=AluSc
ADediting_1181228chr5_151268178_+SINEAluName=AluSc
ADediting_1181229chr5_151268180_+SINEAluName=AluSc
ADediting_1181230chr5_151268183_+SINEAluName=AluSc
ADediting_1181231chr5_151268188_+SINEAluName=AluSc
ADediting_1181232chr5_151268220_+SINEAluName=AluSc
ADediting_1181233chr5_151268236_+SINEAluName=AluSc
ADediting_1181234chr5_151268255_+SINEAluName=AluSc
ADediting_1181235chr5_151268256_+SINEAluName=AluSc
ADediting_1181236chr5_151268259_+SINEAluName=AluSc
ADediting_1181237chr5_151268260_+SINEAluName=AluSc
ADediting_1181238chr5_151268273_+SINEAluName=AluSc
ADediting_1181239chr5_151268282_+SINEAluName=AluSc
ADediting_1181240chr5_151268285_+SINEAluName=AluSc
ADediting_1181241chr5_151268295_+SINEAluName=AluSc
ADediting_1181242chr5_151268320_+SINEAluName=AluSc
ADediting_1181243chr5_151268329_+SINEAluName=AluSc
ADediting_1181244chr5_151268335_+SINEAluName=AluSc
ADediting_1181245chr5_151268338_+SINEAluName=AluSc
ADediting_1181246chr5_151268352_+SINEAluName=AluSc
ADediting_1181247chr5_151268355_+SINEAluName=AluSc
ADediting_1181248chr5_151268364_+SINEAluName=AluSc
ADediting_1181249chr5_151268400_+SINEAluName=AluSc
ADediting_1181250chr5_151268414_+SINEAluName=AluSc
ADediting_1181251chr5_151268415_+SINEAluName=AluSc
ADediting_1181252chr5_151268426_+SINEAluName=AluSc
ADediting_1181253chr5_151268432_+SINEAluName=AluSc
ADediting_1181254chr5_151268435_+SINEAluName=AluSc
ADediting_1181255chr5_151268442_+SINEAluName=AluSc
ADediting_1181256chr5_151268584_+DNAhAT-CharlieName=MER102a
ADediting_1655541chr5_151268281_+SINEAluName=AluSc

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RNA A-to-I editing events in the alternative splicing sites for GM2A

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GM2A

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs