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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for GCLM |
 Gene summary |
| Gene information | Gene symbol | GCLM | Gene ID | 2730 |
| Gene name | glutamate-cysteine ligase modifier subunit | |
| Synonyms | GLCLR | |
| Cytomap | 1p22.1 | |
| Type of gene | protein-coding | |
| Description | glutamate--cysteine ligase regulatory subunitGCS light chainGSC light chaingamma-ECS regulatory subunitgamma-glutamylcysteine synthetase regulatory subunitglutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD)glutamate-cy | |
| Modification date | 20200313 | |
| UniProtAcc | P48507, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| GCLM | GO:0006536 | glutamate metabolic process | 9841880|9895302 |
| GCLM | GO:0006750 | glutathione biosynthetic process | 10395918 |
| GCLM | GO:0006979 | response to oxidative stress | 10395918 |
| GCLM | GO:0042493 | response to drug | 9895302 |
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RNA A-to-I events for GCLM |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_151059(93887132, -), ADediting_151060(93887608, -), ADediting_151061(93891001, -), ADediting_151062(93891087, -), ADediting_151063(93891096, -), ADediting_151064(93891138, -), ADediting_151065(93891159, -), ADediting_151066(93891166, -), ADediting_151067(93893995, -), ADediting_151068(93894066, -), ADediting_151069(93894070, -), ADediting_151070(93894086, -), ADediting_151071(93894114, -), ADediting_151072(93894158, -), ADediting_151073(93894215, -), ADediting_151074(93894218, -), ADediting_151075(93902373, -), ADediting_151076(93904994, -), ADediting_151077(93905113, -), ADediting_151078(93905118, -), ADediting_151079(93905121, -), ADediting_1521839(93887174, -), ADediting_1521840(93887609, -), ADediting_1521841(93887747, -), ADediting_1521842(93890008, -), ADediting_1521843(93890020, -), ADediting_1521844(93890049, -), ADediting_1521845(93890050, -), ADediting_1521846(93894189, -), |
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RNA editing positional annotations for GCLM using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_151059 | chr1_93887132_- | UTR3 |
| ADediting_151060 | chr1_93887608_- | UTR3 |
| ADediting_151061 | chr1_93891001_- | intronic |
| ADediting_151062 | chr1_93891087_- | intronic |
| ADediting_151063 | chr1_93891096_- | intronic |
| ADediting_151064 | chr1_93891138_- | intronic |
| ADediting_151065 | chr1_93891159_- | intronic |
| ADediting_151066 | chr1_93891166_- | intronic |
| ADediting_151067 | chr1_93893995_- | intronic |
| ADediting_151068 | chr1_93894066_- | intronic |
| ADediting_151069 | chr1_93894070_- | intronic |
| ADediting_151070 | chr1_93894086_- | intronic |
| ADediting_151071 | chr1_93894114_- | intronic |
| ADediting_151072 | chr1_93894158_- | intronic |
| ADediting_151073 | chr1_93894215_- | intronic |
| ADediting_151074 | chr1_93894218_- | intronic |
| ADediting_151075 | chr1_93902373_- | intronic |
| ADediting_151076 | chr1_93904994_- | intronic |
| ADediting_151077 | chr1_93905113_- | intronic |
| ADediting_151078 | chr1_93905118_- | intronic |
| ADediting_151079 | chr1_93905121_- | intronic |
| ADediting_1521839 | chr1_93887174_- | UTR3 |
| ADediting_1521840 | chr1_93887609_- | UTR3 |
| ADediting_1521841 | chr1_93887747_- | UTR3 |
| ADediting_1521842 | chr1_93890008_- | intronic |
| ADediting_1521843 | chr1_93890020_- | intronic |
| ADediting_1521844 | chr1_93890049_- | intronic |
| ADediting_1521845 | chr1_93890050_- | intronic |
| ADediting_1521846 | chr1_93894189_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_151059 | chr1_93887132_- | SINE | Alu | Name=AluSx1 |
| ADediting_151060 | chr1_93887608_- | SINE | Alu | Name=AluSg |
| ADediting_151061 | chr1_93891001_- | SINE | Alu | Name=AluJr |
| ADediting_151062 | chr1_93891087_- | SINE | Alu | Name=AluJr |
| ADediting_151063 | chr1_93891096_- | SINE | Alu | Name=AluJr |
| ADediting_151064 | chr1_93891138_- | SINE | Alu | Name=AluJr |
| ADediting_151065 | chr1_93891159_- | SINE | Alu | Name=AluJr |
| ADediting_151066 | chr1_93891166_- | SINE | Alu | Name=AluJr |
| ADediting_151067 | chr1_93893995_- | SINE | Alu | Name=AluJb |
| ADediting_151068 | chr1_93894066_- | SINE | Alu | Name=AluJb |
| ADediting_151069 | chr1_93894070_- | SINE | Alu | Name=AluJb |
| ADediting_151070 | chr1_93894086_- | SINE | Alu | Name=AluJb |
| ADediting_151071 | chr1_93894114_- | SINE | Alu | Name=AluJb |
| ADediting_151072 | chr1_93894158_- | SINE | Alu | Name=AluJb |
| ADediting_151073 | chr1_93894215_- | SINE | Alu | Name=AluJb |
| ADediting_151074 | chr1_93894218_- | SINE | Alu | Name=AluJb |
| ADediting_151075 | chr1_93902373_- | SINE | Alu | Name=AluY |
| ADediting_151076 | chr1_93904994_- | SINE | Alu | Name=AluSz |
| ADediting_151077 | chr1_93905113_- | SINE | Alu | Name=AluSz |
| ADediting_151078 | chr1_93905118_- | SINE | Alu | Name=AluSz |
| ADediting_151079 | chr1_93905121_- | SINE | Alu | Name=AluSz |
| ADediting_1521839 | chr1_93887174_- | SINE | Alu | Name=AluSx1 |
| ADediting_1521840 | chr1_93887609_- | SINE | Alu | Name=AluSg |
| ADediting_1521841 | chr1_93887747_- | SINE | Alu | Name=AluSg |
| ADediting_1521842 | chr1_93890008_- | SINE | Alu | Name=AluSx |
| ADediting_1521843 | chr1_93890020_- | SINE | Alu | Name=AluSx |
| ADediting_1521844 | chr1_93890049_- | SINE | Alu | Name=AluSx |
| ADediting_1521845 | chr1_93890050_- | SINE | Alu | Name=AluSx |
| ADediting_1521846 | chr1_93894189_- | SINE | Alu | Name=AluJb |
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RNA A-to-I editing events in the alternative splicing sites for GCLM |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GCLM |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
 | |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for GCLM |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for GCLM |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_151059 | chr1_93887132_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-8052 | chr1 | 93887127 | 93887133 | 7mer-1a | 93887127 | 93887147 | 145 | -25.42 |
| ADediting_151059 | chr1_93887132_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-8052 | chr1 | 93887127 | 93887133 | 7mer-1a | 93887127 | 93887147 | 145 | -25.42 |
| ADediting_151060 | chr1_93887608_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-3672 | chr1 | 93887603 | 93887609 | 7mer-m8 | 93887602 | 93887625 | 146 | -14.67 |
| ADediting_151060 | chr1_93887608_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-6864-3p | chr1 | 93887603 | 93887609 | 7mer-m8 | 93887602 | 93887622 | 142 | -11.42 |
| ADediting_151060 | chr1_93887608_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-3672 | chr1 | 93887603 | 93887609 | 7mer-m8 | 93887602 | 93887625 | 146 | -14.67 |
| ADediting_151060 | chr1_93887608_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-6864-3p | chr1 | 93887603 | 93887609 | 7mer-m8 | 93887602 | 93887622 | 142 | -11.42 |
| ADediting_1521839 | chr1_93887174_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-214-3p | chr1 | 93887173 | 93887179 | 7mer-1a | 93887173 | 93887194 | 141 | -19.01 |
| ADediting_1521839 | chr1_93887174_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-4291 | chr1 | 93887172 | 93887179 | 8mer-1a | 93887172 | 93887187 | 158 | -20.15 |
| ADediting_1521839 | chr1_93887174_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-922 | chr1 | 93887173 | 93887180 | 8mer-1a | 93887173 | 93887194 | 151 | -20.17 |
| ADediting_1521839 | chr1_93887174_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-214-3p | chr1 | 93887173 | 93887179 | 7mer-1a | 93887173 | 93887194 | 141 | -19.01 |
| ADediting_1521839 | chr1_93887174_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-4291 | chr1 | 93887172 | 93887179 | 8mer-1a | 93887172 | 93887187 | 158 | -20.15 |
| ADediting_1521839 | chr1_93887174_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-922 | chr1 | 93887173 | 93887180 | 8mer-1a | 93887173 | 93887194 | 151 | -20.17 |
| ADediting_1521840 | chr1_93887609_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-513a-5p | chr1 | 93887608 | 93887614 | 7mer-m8 | 93887607 | 93887624 | 156 | -22.58 |
| ADediting_1521840 | chr1_93887609_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-513a-5p | chr1 | 93887608 | 93887614 | 7mer-m8 | 93887607 | 93887624 | 156 | -22.58 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_151059 | chr1_93887132_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-10399-5p | chr1 | 93887131 | 93887137 | 7mer-m8 | 93887130 | 93887150 | 140 | -12.79 |
| ADediting_151059 | chr1_93887132_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-5089-5p | chr1 | 93887127 | 93887133 | 7mer-m8 | 93887126 | 93887144 | 151 | -14.16 |
| ADediting_151059 | chr1_93887132_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-6504-3p | chr1 | 93887131 | 93887137 | 7mer-m8 | 93887130 | 93887151 | 153 | -13.69 |
| ADediting_151059 | chr1_93887132_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-10399-5p | chr1 | 93887131 | 93887137 | 7mer-m8 | 93887130 | 93887150 | 140 | -12.79 |
| ADediting_151059 | chr1_93887132_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-5089-5p | chr1 | 93887127 | 93887133 | 7mer-m8 | 93887126 | 93887144 | 151 | -14.16 |
| ADediting_151059 | chr1_93887132_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-6504-3p | chr1 | 93887131 | 93887137 | 7mer-m8 | 93887130 | 93887151 | 153 | -13.69 |
| ADediting_151060 | chr1_93887608_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-10399-5p | chr1 | 93887607 | 93887613 | 7mer-m8 | 93887606 | 93887627 | 144 | -10.84 |
| ADediting_151060 | chr1_93887608_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-6504-3p | chr1 | 93887607 | 93887613 | 7mer-m8 | 93887606 | 93887627 | 148 | -12.4 |
| ADediting_151060 | chr1_93887608_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-10399-5p | chr1 | 93887607 | 93887613 | 7mer-m8 | 93887606 | 93887627 | 144 | -10.84 |
| ADediting_151060 | chr1_93887608_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-6504-3p | chr1 | 93887607 | 93887613 | 7mer-m8 | 93887606 | 93887627 | 148 | -12.4 |
| ADediting_1521839 | chr1_93887174_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-374b-3p | chr1 | 93887172 | 93887179 | 8mer-1a | 93887172 | 93887197 | 151 | -16.65 |
| ADediting_1521839 | chr1_93887174_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-374b-3p | chr1 | 93887172 | 93887179 | 8mer-1a | 93887172 | 93887197 | 151 | -16.65 |
| ADediting_1521840 | chr1_93887609_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-10399-5p | chr1 | 93887607 | 93887613 | 7mer-m8 | 93887606 | 93887627 | 144 | -10.84 |
| ADediting_1521840 | chr1_93887609_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-6504-3p | chr1 | 93887607 | 93887613 | 7mer-m8 | 93887606 | 93887627 | 148 | -12.4 |
| ADediting_1521840 | chr1_93887609_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-7151-3p | chr1 | 93887608 | 93887615 | 8mer-1a | 93887608 | 93887626 | 144 | -13.15 |
| ADediting_1521840 | chr1_93887609_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-10399-5p | chr1 | 93887607 | 93887613 | 7mer-m8 | 93887606 | 93887627 | 144 | -10.84 |
| ADediting_1521840 | chr1_93887609_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-6504-3p | chr1 | 93887607 | 93887613 | 7mer-m8 | 93887606 | 93887627 | 148 | -12.4 |
| ADediting_1521840 | chr1_93887609_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-7151-3p | chr1 | 93887608 | 93887615 | 8mer-1a | 93887608 | 93887626 | 144 | -13.15 |
| ADediting_1521841 | chr1_93887747_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-552-3p | chr1 | 93887741 | 93887748 | 8mer-1a | 93887741 | 93887761 | 140 | -14.09 |
| ADediting_1521841 | chr1_93887747_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-552-3p | chr1 | 93887741 | 93887748 | 8mer-1a | 93887741 | 93887761 | 140 | -14.09 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-4477b | chr1 | 93888199 | 93888205 | 7mer-m8 | 93888198 | 93888217 | 157 | -15.11 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-4477b | chr1 | 93888199 | 93888205 | 7mer-m8 | 93888198 | 93888217 | 157 | -15.11 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-381-3p | chr1 | 93887180 | 93887186 | 7mer-m8 | 93887179 | 93887200 | 145 | -16.01 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-381-3p | chr1 | 93887180 | 93887186 | 7mer-m8 | 93887179 | 93887200 | 145 | -16.01 |
| ADediting_1596844 | chr1_162342605_+ | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-556-3p | chr1 | 93888136 | 93888142 | 7mer-m8 | 93888135 | 93888155 | 154 | -16.42 |
| ADediting_1596844 | chr1_162342605_+ | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-556-3p | chr1 | 93888136 | 93888142 | 7mer-m8 | 93888135 | 93888155 | 154 | -16.42 |
| ADediting_98288 | chr1_32086990_+ | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-5585-3p | chr1 | 93888214 | 93888220 | 7mer-m8 | 93888213 | 93888234 | 150 | -14.06 |
| ADediting_98288 | chr1_32086990_+ | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-5585-3p | chr1 | 93888214 | 93888220 | 7mer-m8 | 93888213 | 93888234 | 150 | -14.06 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-5585-3p | chr1 | 93888209 | 93888215 | 7mer-1a | 93888209 | 93888230 | 143 | -9.41 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-5585-3p | chr1 | 93888209 | 93888215 | 7mer-1a | 93888209 | 93888230 | 143 | -9.41 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-4477b | chr1 | 93888027 | 93888033 | 7mer-m8 | 93888026 | 93888047 | 151 | -8.79 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-4477b | chr1 | 93888782 | 93888789 | 8mer-1a | 93888782 | 93888803 | 144 | -6.87 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-4477b | chr1 | 93888027 | 93888033 | 7mer-m8 | 93888026 | 93888047 | 151 | -8.79 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-4477b | chr1 | 93888782 | 93888789 | 8mer-1a | 93888782 | 93888803 | 144 | -6.87 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-4477b | chr1 | 93888027 | 93888033 | 7mer-m8 | 93888026 | 93888047 | 151 | -8.79 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-4477b | chr1 | 93888782 | 93888789 | 8mer-1a | 93888782 | 93888803 | 144 | -6.87 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-4477b | chr1 | 93888027 | 93888033 | 7mer-m8 | 93888026 | 93888047 | 151 | -8.79 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-4477b | chr1 | 93888782 | 93888789 | 8mer-1a | 93888782 | 93888803 | 144 | -6.87 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-381-3p | chr1 | 93887465 | 93887471 | 7mer-m8 | 93887464 | 93887485 | 146 | -11.26 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-381-3p | chr1 | 93887771 | 93887777 | 7mer-m8 | 93887770 | 93887791 | 146 | -11.52 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-381-3p | chr1 | 93888386 | 93888392 | 7mer-m8 | 93888385 | 93888406 | 154 | -12.14 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-381-3p | chr1 | 93887465 | 93887471 | 7mer-m8 | 93887464 | 93887485 | 146 | -11.26 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-381-3p | chr1 | 93887771 | 93887777 | 7mer-m8 | 93887770 | 93887791 | 146 | -11.52 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-381-3p | chr1 | 93888386 | 93888392 | 7mer-m8 | 93888385 | 93888406 | 154 | -12.14 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-381-3p | chr1 | 93887465 | 93887471 | 7mer-m8 | 93887464 | 93887485 | 146 | -11.26 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-381-3p | chr1 | 93887771 | 93887777 | 7mer-m8 | 93887770 | 93887791 | 146 | -11.52 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-381-3p | chr1 | 93888386 | 93888392 | 7mer-m8 | 93888385 | 93888406 | 154 | -12.14 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-381-3p | chr1 | 93887465 | 93887471 | 7mer-m8 | 93887464 | 93887485 | 146 | -11.26 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-381-3p | chr1 | 93887771 | 93887777 | 7mer-m8 | 93887770 | 93887791 | 146 | -11.52 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-381-3p | chr1 | 93888386 | 93888392 | 7mer-m8 | 93888385 | 93888406 | 154 | -12.14 |
| ADediting_286380 | chr11_79422188_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-5579-3p | chr1 | 93887864 | 93887870 | 7mer-m8 | 93887863 | 93887884 | 143 | -7.8 |
| ADediting_286380 | chr11_79422188_- | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-5579-3p | chr1 | 93887864 | 93887870 | 7mer-m8 | 93887863 | 93887884 | 143 | -7.8 |
| ADediting_291761 | chr11_93733708_- | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-1304-3p | chr1 | 93886267 | 93886274 | 8mer-1a | 93886267 | 93886288 | 144 | -17.39 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-4775 | chr1 | 93885876 | 93885882 | 7mer-m8 | 93885875 | 93885895 | 148 | -8.46 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000023909.10 | ENST00000370238.8 | GCLM-201 | hsa-miR-4775 | chr1 | 93887301 | 93887307 | 7mer-m8 | 93887300 | 93887322 | 147 | -6.38 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000023909.10 | ENST00000615724.1 | GCLM-204 | hsa-miR-4775 | chr1 | 93887301 | 93887307 | 7mer-m8 | 93887300 | 93887322 | 147 | -6.38 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for GCLM |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000370238.8 | protein_coding |  |  |
| ENST00000615724.1 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_151059 | ENST00000370238.8 | chr1_93887132_- | 2950 | -1283.90 | -1283.90 | -1293.40 |
| ADediting_1521839 | ENST00000370238.8 | chr1_93887174_- | 2908 | -1284.20 | -1283.90 | -1293.40 |
| ADediting_151060 | ENST00000370238.8 | chr1_93887608_- | 2474 | -1287.80 | -1283.90 | -1293.40 |
| ADediting_1521840 | ENST00000370238.8 | chr1_93887609_- | 2473 | -1285.00 | -1283.90 | -1293.40 |
| ADediting_1521841 | ENST00000370238.8 | chr1_93887747_- | 2335 | -1289.30 | -1283.90 | -1293.40 |
| ADediting_151059 | ENST00000615724.1 | chr1_93887132_- | 2910 | -905.60 | -905.60 | -910.50 |
| ADediting_1521839 | ENST00000615724.1 | chr1_93887174_- | 2868 | -905.90 | -905.60 | -910.50 |
| ADediting_151060 | ENST00000615724.1 | chr1_93887608_- | 2434 | -908.10 | -905.60 | -910.50 |
| ADediting_1521840 | ENST00000615724.1 | chr1_93887609_- | 2433 | -906.50 | -905.60 | -910.50 |
| ADediting_1521841 | ENST00000615724.1 | chr1_93887747_- | 2295 | -906.00 | -905.60 | -910.50 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for GCLM |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_151069 | chr1_93894070_- | 0.00457608250753658 | 0.230319519325913 | 4.86232907868006e-05 | 0.32532614766877 | 0.309479598145841 | 0.0835354123172178 |
| CER | ADediting_151070 | chr1_93894086_- | 0.0127560800699758 | 0.202926325235428 | 6.90536875891358e-06 | 0.357902305046399 | 0.516521416549093 | 0.0533762481309034 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 8.40891571252583e-48 | 0.704580285635851 | 3.05597830863979e-23 | 0.523798357617539 | 9.04756036002431e-09 | 0.319158790044368 |
| AC | 2.85348869560439e-53 | 0.783994211217064 | 1.54035272213376e-25 | 0.59705201823769 | 1.67657921278368e-17 | 0.503876615237341 |
| PCC | 5.25861694260059e-31 | 0.713391784972859 | 5.50678557790052e-27 | 0.677261581089397 | 0.000509744680875116 | 0.249142405706312 |
| CER | 4.78381726058984e-10 | 0.480719226723382 | 1.836517506915e-05 | 0.342031163916194 | 0.00632013288250929 | 0.22202758294382 |
| TCX | 2.22009717060712e-17 | 0.621233866721712 | 0.000264454144764511 | 0.293705410862563 | 0.00135970258945494 | 0.259213131344346 |
| FP | 3.93668372193243e-17 | 0.576170660739542 | 4.10999413488073e-19 | 0.604472468013306 | 0.794323275040337 | 0.0196770867823679 |
| IFG | 4.73110889554052e-05 | 0.721290921725895 | 0.000386665450192309 | 0.65442342877239 | 0.936245499767736 | -0.0168600137075799 |
| PG | 3.3404030346136e-36 | 0.759509155616454 | 2.6050542663854e-17 | 0.568447579634859 | 0.983636108072436 | 0.00151411164930531 |
| STG | 2.50116589555131e-10 | 0.622900442722583 | 1.33910744673927e-10 | 0.630157901385086 | 0.47520965602396 | -0.0789683444114015 |
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Relation with AD stages for GCLM |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 8.56721914614244e-05 | 0.372132404904208 |
| STG | 0.00478800660290046 | -0.304992346906708 |
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RelatedDrugs for GCLM |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| GCLM | P48507 | DB00142 | Glutamic Acid | Glutamate--cysteine ligase regulatory subunit | small molecule | approved|nutraceutical |
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RelatedDiseases for GCLM |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| GCLM | C0036341 | Schizophrenia | 3 | PSYGENET |
| GCLM | C0027051 | Myocardial Infarction | 2 | CTD_human |
| GCLM | C0005138 | Berylliosis | 1 | CTD_human |
| GCLM | C0033937 | Psychoses, Drug | 1 | PSYGENET |
| GCLM | C0036939 | Shared Paranoid Disorder | 1 | PSYGENET |
| GCLM | C2350873 | Beryllium Disease | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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