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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for STK36 |
 Gene summary |
| Gene information | Gene symbol | STK36 | Gene ID | 27148 |
| Gene name | serine/threonine kinase 36 | |
| Synonyms | FU | |
| Cytomap | 2q35 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase 36fused homologtesticular tissue protein Li 188 | |
| Modification date | 20200313 | |
| UniProtAcc | Q9NRP7, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| STK36 | GO:0051090 | regulation of DNA-binding transcription factor activity | 10806483 |
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RNA A-to-I events for STK36 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_847795(218687908, +), ADediting_847796(218687962, +), ADediting_847797(218687972, +), ADediting_847798(218699086, +), ADediting_847799(218700673, +), ADediting_847800(218700757, +), ADediting_847801(218701347, +), ADediting_1635935(218688037, +), |
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RNA editing positional annotations for STK36 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_847798 | chr2_218699086_+ | nonsynonymous SNV | ENST00000440309.5 | c.A3542G | p.Y1181C | 0.001 | 0.614 | -6.04 |
| ADediting_847798 | chr2_218699086_+ | nonsynonymous SNV | ENST00000392105.7 | c.A3479G | p.Y1160C | 0.001 | 0.614 | -6.04 |
| ADediting_847798 | chr2_218699086_+ | nonsynonymous SNV | ENST00000295709.8 | c.A3542G | p.Y1181C | 0.001 | 0.614 | -6.04 |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_847795 | chr2_218687908_+ | intronic |
| ADediting_847796 | chr2_218687962_+ | intronic |
| ADediting_847797 | chr2_218687972_+ | intronic |
| ADediting_847798 | chr2_218699086_+ | exonic |
| ADediting_847799 | chr2_218700673_+ | intronic |
| ADediting_847800 | chr2_218700757_+ | intronic |
| ADediting_847801 | chr2_218701347_+ | intronic |
| ADediting_1635935 | chr2_218688037_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_847795 | chr2_218687908_+ | SINE | Alu | Name=AluSq2 |
| ADediting_847796 | chr2_218687962_+ | SINE | Alu | Name=AluSq2 |
| ADediting_847797 | chr2_218687972_+ | SINE | Alu | Name=AluSq2 |
| ADediting_847799 | chr2_218700673_+ | SINE | Alu | Name=AluSz |
| ADediting_847800 | chr2_218700757_+ | SINE | Alu | Name=AluSx1 |
| ADediting_847801 | chr2_218701347_+ | SINE | Alu | Name=AluY |
| ADediting_1635935 | chr2_218688037_+ | SINE | Alu | Name=AluSq2 |
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RNA A-to-I editing events in the alternative splicing sites for STK36 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for STK36 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for STK36 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for STK36 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for STK36 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000392105.7 | protein_coding |  |  |
| ENST00000295709.8 | protein_coding |  |  |
| ENST00000440309.5 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_847798 | ENST00000392105.7 | chr2_218699086_+ | 3715 | -1814.00 | -1807.60 | -1814.00 |
| ADediting_847798 | ENST00000295709.8 | chr2_218699086_+ | 3761 | -1823.00 | -1816.60 | -1823.00 |
| ADediting_847798 | ENST00000440309.5 | chr2_218699086_+ | 3701 | -1772.40 | -1766.00 | -1772.40 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for STK36 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_847798 | chr2_218699086_+ | 4.99720704360499e-05 | 0.228226227421404 | 3.72506249685185e-10 | 0.346172152492339 | 0.954884436278674 | -0.00322621992752226 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.19586748785118e-25 | 0.547560874699426 | 6.38542597284429e-50 | 0.71560688134288 | 7.38688484908517e-06 | 0.251486088202597 |
| AC | 2.25117226092548e-22 | 0.563761932220605 | 2.57875212318736e-16 | 0.487301926569655 | 5.50541855419368e-13 | 0.43536558037017 |
| PCC | 1.07489856432999e-05 | 0.312521095738774 | 1.21902506469336e-05 | 0.310674820021429 | 3.47921433548582e-07 | 0.35870429319897 |
| CER | 9.06182498825814e-15 | 0.578431053564915 | 1.99684600864506e-22 | 0.688802414155109 | 0.00192946635763088 | 0.251214337686335 |
| TCX | 1.89322699526698e-09 | 0.465810174502876 | 3.31823990476866e-13 | 0.549428633798777 | 0.165899385028944 | 0.11370963399762 |
| FP | 3.20509346413737e-23 | 0.65540272219045 | 2.12875868354898e-24 | 0.668388455718383 | 4.43877840064951e-06 | 0.33630825001067 |
| IFG | 0.0001029934155649 | 0.698514153868425 | 2.0899422130177e-06 | 0.794688930461633 | 0.0108845155437213 | 0.500206044870353 |
| PG | 3.08112501760406e-22 | 0.633228061365899 | 5.98618017463148e-26 | 0.673616022041523 | 0.656893972263509 | 0.0327829747042877 |
| STG | 2.3228222431802e-07 | 0.528865045638822 | 1.71952715951435e-08 | 0.568252098075541 | 0.158402610759845 | 0.155285790667337 |
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Relation with AD stages for STK36 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 5.16015123627611e-07 | 0.460955022559241 |
| TCX | 1.3111782178755e-05 | 0.409451559095245 |
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RelatedDrugs for STK36 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| STK36 | Q9NRP7 | DB12010 | Fostamatinib | Serine/threonine-protein kinase 36 | small molecule | approved|investigational |
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RelatedDiseases for STK36 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| STK36 | C0238198 | Gastrointestinal Stromal Tumors | 1 | CTD_human |
| STK36 | C3179349 | Gastrointestinal Stromal Sarcoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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