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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for SH3YL1 |
 Gene summary |
| Gene information | Gene symbol | SH3YL1 | Gene ID | 26751 |
| Gene name | SH3 and SYLF domain containing 1 | |
| Synonyms | RAY | |
| Cytomap | 2p25.3 | |
| Type of gene | protein-coding | |
| Description | SH3 domain-containing YSC84-like protein 1SH3 domain containing, Ysc84-like 1 | |
| Modification date | 20200313 | |
| UniProtAcc | Q96HL8, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for SH3YL1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_850658(230556, -), ADediting_850659(230620, -), ADediting_850660(230621, -), ADediting_850661(230631, -), ADediting_850662(230635, -), ADediting_850663(230644, -), ADediting_850664(230647, -), ADediting_850665(230671, -), ADediting_850666(230680, -), ADediting_850670(230712, -), ADediting_850671(230713, -), ADediting_850773(230736, -), ADediting_853144(234920, -), ADediting_853152(235015, -), ADediting_858926(244307, -), ADediting_861745(256569, -), ADediting_861746(256581, -), ADediting_1562507(230618, -), ADediting_1562508(230705, -), ADediting_1562509(230739, -), ADediting_1562510(230755, -), |
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RNA editing positional annotations for SH3YL1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_850658 | chr2_230556_- | UTR3 |
| ADediting_850659 | chr2_230620_- | UTR3 |
| ADediting_850660 | chr2_230621_- | UTR3 |
| ADediting_850661 | chr2_230631_- | UTR3 |
| ADediting_850662 | chr2_230635_- | UTR3 |
| ADediting_850663 | chr2_230644_- | UTR3 |
| ADediting_850664 | chr2_230647_- | UTR3 |
| ADediting_850665 | chr2_230671_- | UTR3 |
| ADediting_850666 | chr2_230680_- | UTR3 |
| ADediting_850670 | chr2_230712_- | UTR3 |
| ADediting_850671 | chr2_230713_- | UTR3 |
| ADediting_850773 | chr2_230736_- | UTR3 |
| ADediting_853144 | chr2_234920_- | intronic |
| ADediting_853152 | chr2_235015_- | intronic |
| ADediting_858926 | chr2_244307_- | intronic |
| ADediting_861745 | chr2_256569_- | UTR5 |
| ADediting_861746 | chr2_256581_- | UTR5 |
| ADediting_1562507 | chr2_230618_- | UTR3 |
| ADediting_1562508 | chr2_230705_- | UTR3 |
| ADediting_1562509 | chr2_230739_- | UTR3 |
| ADediting_1562510 | chr2_230755_- | UTR3 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_850658 | chr2_230556_- | SINE | Alu | Name=AluSz6 |
| ADediting_850659 | chr2_230620_- | SINE | Alu | Name=AluSz6 |
| ADediting_850660 | chr2_230621_- | SINE | Alu | Name=AluSz6 |
| ADediting_850661 | chr2_230631_- | SINE | Alu | Name=AluSz6 |
| ADediting_850662 | chr2_230635_- | SINE | Alu | Name=AluSz6 |
| ADediting_850663 | chr2_230644_- | SINE | Alu | Name=AluSz6 |
| ADediting_850664 | chr2_230647_- | SINE | Alu | Name=AluSz6 |
| ADediting_850665 | chr2_230671_- | SINE | Alu | Name=AluSz6 |
| ADediting_850666 | chr2_230680_- | SINE | Alu | Name=AluSz6 |
| ADediting_850670 | chr2_230712_- | SINE | Alu | Name=AluSz6 |
| ADediting_850671 | chr2_230713_- | SINE | Alu | Name=AluSz6 |
| ADediting_850773 | chr2_230736_- | SINE | Alu | Name=AluSz6 |
| ADediting_853144 | chr2_234920_- | SINE | Alu | Name=AluSq |
| ADediting_853152 | chr2_235015_- | SINE | Alu | Name=AluSq |
| ADediting_858926 | chr2_244307_- | SINE | Alu | Name=AluSc8 |
| ADediting_861745 | chr2_256569_- | SINE | Alu | Name=AluSq2 |
| ADediting_861746 | chr2_256581_- | SINE | Alu | Name=AluSq2 |
| ADediting_1562507 | chr2_230618_- | SINE | Alu | Name=AluSz6 |
| ADediting_1562508 | chr2_230705_- | SINE | Alu | Name=AluSz6 |
| ADediting_1562509 | chr2_230739_- | SINE | Alu | Name=AluSz6 |
| ADediting_1562510 | chr2_230755_- | SINE | Alu | Name=AluSz6 |
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RNA A-to-I editing events in the alternative splicing sites for SH3YL1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SH3YL1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for SH3YL1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for SH3YL1 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_850659 | chr2_230620_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-3977 | chr2 | 230618 | 230624 | 7mer-m8 | 230617 | 230642 | 146 | -10.11 |
| ADediting_850660 | chr2_230621_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-4421 | chr2 | 230615 | 230622 | 8mer-1a | 230615 | 230636 | 140 | -15.53 |
| ADediting_850660 | chr2_230621_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-5699-3p | chr2 | 230615 | 230622 | 8mer-1a | 230615 | 230636 | 155 | -23.74 |
| ADediting_850660 | chr2_230621_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-6748-3p | chr2 | 230615 | 230621 | 7mer-1a | 230615 | 230635 | 141 | -26.72 |
| ADediting_850662 | chr2_230635_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-646 | chr2 | 230633 | 230639 | 7mer-m8 | 230632 | 230650 | 145 | -14.68 |
| ADediting_850663 | chr2_230644_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-10525-3p | chr2 | 230642 | 230648 | 7mer-m8 | 230641 | 230660 | 150 | -16.14 |
| ADediting_850663 | chr2_230644_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-3672 | chr2 | 230639 | 230645 | 7mer-m8 | 230638 | 230659 | 146 | -14.83 |
| ADediting_850663 | chr2_230644_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-6864-3p | chr2 | 230639 | 230645 | 7mer-m8 | 230638 | 230658 | 140 | -12.54 |
| ADediting_850666 | chr2_230680_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-153-5p | chr2 | 230680 | 230686 | 7mer-m8 | 230679 | 230700 | 154 | -12.39 |
| ADediting_850670 | chr2_230712_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-3190-5p | chr2 | 230712 | 230718 | 7mer-m8 | 230711 | 230730 | 152 | -19.64 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1562507 | chr2_230618_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-660-3p | chr2 | 230612 | 230619 | 8mer-1a | 230612 | 230631 | 148 | -17.63 |
| ADediting_1562508 | chr2_230705_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-19a-5p | chr2 | 230701 | 230707 | 7mer-m8 | 230700 | 230721 | 152 | -12.09 |
| ADediting_1562508 | chr2_230705_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-19b-1-5p | chr2 | 230701 | 230707 | 7mer-m8 | 230700 | 230723 | 155 | -15.31 |
| ADediting_1562508 | chr2_230705_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-19b-2-5p | chr2 | 230701 | 230707 | 7mer-m8 | 230700 | 230722 | 155 | -12.76 |
| ADediting_1562508 | chr2_230705_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-4659a-5p | chr2 | 230704 | 230711 | 8mer-1a | 230704 | 230725 | 145 | -13.59 |
| ADediting_1562508 | chr2_230705_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-4659b-5p | chr2 | 230704 | 230711 | 8mer-1a | 230704 | 230722 | 145 | -13.85 |
| ADediting_1562509 | chr2_230739_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-4695-3p | chr2 | 230736 | 230743 | 8mer-1a | 230736 | 230757 | 153 | -22.02 |
| ADediting_1562509 | chr2_230739_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-513c-5p | chr2 | 230739 | 230745 | 7mer-m8 | 230738 | 230757 | 141 | -15.74 |
| ADediting_1562509 | chr2_230739_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-514b-5p | chr2 | 230739 | 230745 | 7mer-m8 | 230738 | 230759 | 142 | -11.27 |
| ADediting_1562510 | chr2_230755_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-6747-3p | chr2 | 230753 | 230759 | 7mer-m8 | 230752 | 230773 | 155 | -24.8 |
| ADediting_850658 | chr2_230556_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-4774-3p | chr2 | 230551 | 230557 | 7mer-m8 | 230550 | 230572 | 145 | -12.57 |
| ADediting_850658 | chr2_230556_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-645 | chr2 | 230555 | 230561 | 7mer-m8 | 230554 | 230570 | 149 | -19.03 |
| ADediting_850661 | chr2_230631_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-1200 | chr2 | 230628 | 230634 | 7mer-m8 | 230627 | 230646 | 146 | -23.05 |
| ADediting_850661 | chr2_230631_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-6869-5p | chr2 | 230631 | 230637 | 7mer-m8 | 230630 | 230651 | 145 | -15.34 |
| ADediting_850662 | chr2_230635_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-6869-5p | chr2 | 230631 | 230637 | 7mer-m8 | 230630 | 230651 | 145 | -15.34 |
| ADediting_850666 | chr2_230680_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-4482-3p | chr2 | 230676 | 230683 | 8mer-1a | 230676 | 230698 | 154 | -14.76 |
| ADediting_850670 | chr2_230712_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-4716-5p | chr2 | 230707 | 230713 | 7mer-m8 | 230706 | 230727 | 140 | -10.69 |
| ADediting_850670 | chr2_230712_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-4781-3p | chr2 | 230709 | 230715 | 7mer-m8 | 230708 | 230726 | 144 | -13.86 |
| ADediting_850671 | chr2_230713_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-4435 | chr2 | 230712 | 230719 | 8mer-1a | 230712 | 230732 | 146 | -17.79 |
| ADediting_850671 | chr2_230713_- | ENSG00000035115.22 | ENST00000481932.1 | SH3YL1-223 | hsa-miR-4781-3p | chr2 | 230709 | 230715 | 7mer-m8 | 230708 | 230726 | 144 | -13.86 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000035115.22 | ENST00000402632.5 | SH3YL1-202 | hsa-miR-381-3p | chr2 | 241620 | 241626 | 7mer-m8 | 241619 | 241639 | 160 | -16.89 |
| ADediting_98288 | chr1_32086990_+ | ENSG00000035115.22 | ENST00000402632.5 | SH3YL1-202 | hsa-miR-5585-3p | chr2 | 241561 | 241567 | 7mer-m8 | 241560 | 241582 | 143 | -14.9 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000035115.22 | ENST00000402632.5 | SH3YL1-202 | hsa-miR-589-3p | chr2 | 240774 | 240781 | 8mer-1a | 240774 | 240797 | 155 | -19.13 |
| ADediting_1337758 | chr7_5495892_- | ENSG00000035115.22 | ENST00000402632.5 | SH3YL1-202 | hsa-miR-589-5p | chr2 | 240540 | 240546 | 7mer-m8 | 240539 | 240560 | 147 | -14.32 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000035115.22 | ENST00000356150.10 | SH3YL1-201 | hsa-miR-641 | chr2 | 218274 | 218280 | 7mer-m8 | 218273 | 218298 | 149 | -17.31 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000035115.22 | ENST00000402632.5 | SH3YL1-202 | hsa-miR-641 | chr2 | 241821 | 241827 | 7mer-m8 | 241820 | 241847 | 144 | -10.95 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000035115.22 | ENST00000403657.5 | SH3YL1-203 | hsa-miR-641 | chr2 | 218274 | 218280 | 7mer-m8 | 218273 | 218298 | 149 | -17.31 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000035115.22 | ENST00000403712.6 | SH3YL1-205 | hsa-miR-641 | chr2 | 218274 | 218280 | 7mer-m8 | 218273 | 218298 | 149 | -17.31 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000035115.22 | ENST00000405430.5 | SH3YL1-206 | hsa-miR-641 | chr2 | 218274 | 218280 | 7mer-m8 | 218273 | 218298 | 149 | -17.31 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000035115.22 | ENST00000626873.2 | SH3YL1-229 | hsa-miR-641 | chr2 | 218274 | 218280 | 7mer-m8 | 218273 | 218298 | 149 | -17.31 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000035115.22 | ENST00000356150.10 | SH3YL1-201 | hsa-miR-641 | chr2 | 218274 | 218280 | 7mer-m8 | 218273 | 218298 | 149 | -17.31 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000035115.22 | ENST00000402632.5 | SH3YL1-202 | hsa-miR-641 | chr2 | 241821 | 241827 | 7mer-m8 | 241820 | 241847 | 144 | -10.95 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000035115.22 | ENST00000403657.5 | SH3YL1-203 | hsa-miR-641 | chr2 | 218274 | 218280 | 7mer-m8 | 218273 | 218298 | 149 | -17.31 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000035115.22 | ENST00000403712.6 | SH3YL1-205 | hsa-miR-641 | chr2 | 218274 | 218280 | 7mer-m8 | 218273 | 218298 | 149 | -17.31 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000035115.22 | ENST00000405430.5 | SH3YL1-206 | hsa-miR-641 | chr2 | 218274 | 218280 | 7mer-m8 | 218273 | 218298 | 149 | -17.31 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000035115.22 | ENST00000626873.2 | SH3YL1-229 | hsa-miR-641 | chr2 | 218274 | 218280 | 7mer-m8 | 218273 | 218298 | 149 | -17.31 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000035115.22 | ENST00000356150.10 | SH3YL1-201 | hsa-miR-4775 | chr2 | 218329 | 218335 | 7mer-m8 | 218328 | 218349 | 145 | -5.09 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000035115.22 | ENST00000356150.10 | SH3YL1-201 | hsa-miR-4775 | chr2 | 218770 | 218776 | 7mer-m8 | 218769 | 218791 | 155 | -7.71 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000035115.22 | ENST00000403657.5 | SH3YL1-203 | hsa-miR-4775 | chr2 | 218329 | 218335 | 7mer-m8 | 218328 | 218349 | 145 | -5.09 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000035115.22 | ENST00000403657.5 | SH3YL1-203 | hsa-miR-4775 | chr2 | 218770 | 218776 | 7mer-m8 | 218769 | 218791 | 155 | -7.71 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000035115.22 | ENST00000403658.5 | SH3YL1-204 | hsa-miR-4775 | chr2 | 218770 | 218776 | 7mer-m8 | 218769 | 218791 | 155 | -7.71 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000035115.22 | ENST00000403712.6 | SH3YL1-205 | hsa-miR-4775 | chr2 | 218329 | 218335 | 7mer-m8 | 218328 | 218349 | 145 | -5.09 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000035115.22 | ENST00000403712.6 | SH3YL1-205 | hsa-miR-4775 | chr2 | 218770 | 218776 | 7mer-m8 | 218769 | 218791 | 155 | -7.71 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000035115.22 | ENST00000405430.5 | SH3YL1-206 | hsa-miR-4775 | chr2 | 218329 | 218335 | 7mer-m8 | 218328 | 218349 | 145 | -5.09 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000035115.22 | ENST00000405430.5 | SH3YL1-206 | hsa-miR-4775 | chr2 | 218770 | 218776 | 7mer-m8 | 218769 | 218791 | 155 | -7.71 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000035115.22 | ENST00000626873.2 | SH3YL1-229 | hsa-miR-4775 | chr2 | 218329 | 218335 | 7mer-m8 | 218328 | 218349 | 145 | -5.09 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000035115.22 | ENST00000626873.2 | SH3YL1-229 | hsa-miR-4775 | chr2 | 218770 | 218776 | 7mer-m8 | 218769 | 218791 | 155 | -7.71 |
| ADediting_98288 | chr1_32086990_+ | ENSG00000035115.22 | ENST00000402632.5 | SH3YL1-202 | hsa-miR-5585-3p | chr2 | 241187 | 241194 | 8mer-1a | 241187 | 241205 | 141 | -7.88 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000035115.22 | ENST00000402632.5 | SH3YL1-202 | hsa-miR-5585-3p | chr2 | 241187 | 241194 | 8mer-1a | 241187 | 241205 | 141 | -7.88 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for SH3YL1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000481932.1 | protein_coding |  |  |
| ENST00000403657.5 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_850658 | ENST00000481932.1 | chr2_230556_- | 708 | -251.70 | -251.70 | -270.20 |
| ADediting_1562507 | ENST00000481932.1 | chr2_230618_- | 646 | -251.60 | -251.70 | -270.20 |
| ADediting_850659 | ENST00000481932.1 | chr2_230620_- | 644 | -251.70 | -251.70 | -270.20 |
| ADediting_850660 | ENST00000481932.1 | chr2_230621_- | 643 | -252.30 | -251.70 | -270.20 |
| ADediting_850661 | ENST00000481932.1 | chr2_230631_- | 633 | -251.00 | -251.70 | -270.20 |
| ADediting_850662 | ENST00000481932.1 | chr2_230635_- | 629 | -251.40 | -251.70 | -270.20 |
| ADediting_850663 | ENST00000481932.1 | chr2_230644_- | 620 | -252.80 | -251.70 | -270.20 |
| ADediting_850664 | ENST00000481932.1 | chr2_230647_- | 617 | -252.20 | -251.70 | -270.20 |
| ADediting_850665 | ENST00000481932.1 | chr2_230671_- | 593 | -252.50 | -251.70 | -270.20 |
| ADediting_850666 | ENST00000481932.1 | chr2_230680_- | 584 | -254.20 | -251.70 | -270.20 |
| ADediting_1562508 | ENST00000481932.1 | chr2_230705_- | 559 | -251.90 | -251.70 | -270.20 |
| ADediting_850670 | ENST00000481932.1 | chr2_230712_- | 552 | -251.70 | -251.70 | -270.20 |
| ADediting_850671 | ENST00000481932.1 | chr2_230713_- | 551 | -251.30 | -251.70 | -270.20 |
| ADediting_850773 | ENST00000481932.1 | chr2_230736_- | 528 | -251.00 | -251.70 | -270.20 |
| ADediting_1562509 | ENST00000481932.1 | chr2_230739_- | 525 | -252.00 | -251.70 | -270.20 |
| ADediting_1562510 | ENST00000481932.1 | chr2_230755_- | 509 | -251.70 | -251.70 | -270.20 |
| ADediting_861745 | ENST00000403657.5 | chr2_256569_- | 1361 | -964.90 | -965.10 | -964.40 |
| ADediting_861746 | ENST00000403657.5 | chr2_256581_- | 1349 | -964.60 | -965.10 | -964.40 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for SH3YL1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_850664 | chr2_230647_- | 0.0356175862738089 | 0.171727597768554 | 5.36937206932998e-05 | 0.323568597060977 | 0.0952730897915982 | 0.136712524311797 |
| CER | ADediting_861746 | chr2_256581_- | 0.0192805156016587 | 0.19090165153218 | 1.30235615130079e-05 | 0.347705988530368 | 0.559268933681981 | 0.0480519222780182 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.95987720420328e-48 | 0.707925222728953 | 5.30391962771471e-30 | 0.586224058560657 | 1.75434741180632e-29 | 0.581869337020138 |
| AC | 1.31279895729626e-72 | 0.854818327634344 | 2.13489265958165e-47 | 0.755224511015065 | 4.30716553829954e-17 | 0.498255719341808 |
| PCC | 6.66115447383331e-27 | 0.676460380740369 | 1.78779844479521e-25 | 0.662198649677199 | 4.29776612551416e-05 | 0.291464867304171 |
| CER | 2.03811617058488e-31 | 0.775938246625446 | 4.72321446497394e-34 | 0.795789910791934 | 1.19280510120258e-06 | 0.384427492351203 |
| TCX | 2.88751131537574e-25 | 0.720148573074787 | 3.32298558901343e-07 | 0.402365759276823 | 4.94015129722127e-10 | 0.480378755125315 |
| FP | 1.69364768287419e-28 | 0.709005480358185 | 7.66428919674397e-45 | 0.821707722867861 | 3.66110565134006e-05 | 0.304177786808157 |
| IFG | 2.60686858992381e-05 | 0.737380691093303 | 0.000105968188013001 | 0.697639384094631 | 0.000111922012050643 | 0.695951507117645 |
| PG | 9.83661631532072e-51 | 0.839969912549242 | 1.09959603965181e-34 | 0.748693458848835 | 0.622521558385547 | 0.0363286900423138 |
| STG | 6.9528381024499e-14 | 0.705231024803516 | 8.4387677207314e-14 | 0.703561304775274 | 0.0330713149150593 | 0.232817671465613 |
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Relation with AD stages for SH3YL1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 1.65309335939038e-07 | 0.478243421044779 |
| TCX | 1.07395035758254e-08 | 0.520465607203322 |
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RelatedDrugs for SH3YL1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SH3YL1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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