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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for TMEM98 |
 Gene summary |
| Gene information | Gene symbol | TMEM98 | Gene ID | 26022 |
| Gene name | transmembrane protein 98 | |
| Synonyms | TADA1 | |
| Cytomap | 17q11.2 | |
| Type of gene | protein-coding | |
| Description | transmembrane protein 98 | |
| Modification date | 20200313 | |
| UniProtAcc | Q9Y2Y6, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for TMEM98 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_611348(32937668, +), ADediting_611349(32937771, +), ADediting_611350(32937774, +), ADediting_611351(32939163, +), ADediting_611352(32939168, +), ADediting_611353(32939174, +), ADediting_611354(32940474, +), ADediting_611355(32944681, +), ADediting_1546103(32937691, +), ADediting_1546104(32939152, +), ADediting_1626935(32939260, +), |
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RNA editing positional annotations for TMEM98 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_611348 | chr17_32937668_+ | intronic |
| ADediting_611349 | chr17_32937771_+ | intronic |
| ADediting_611350 | chr17_32937774_+ | intronic |
| ADediting_611351 | chr17_32939163_+ | intronic |
| ADediting_611352 | chr17_32939168_+ | intronic |
| ADediting_611353 | chr17_32939174_+ | intronic |
| ADediting_611354 | chr17_32940474_+ | intronic |
| ADediting_611355 | chr17_32944681_+ | intronic |
| ADediting_1546103 | chr17_32937691_+ | intronic |
| ADediting_1546104 | chr17_32939152_+ | intronic |
| ADediting_1626935 | chr17_32939260_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_611348 | chr17_32937668_+ | SINE | Alu | Name=AluSx1 |
| ADediting_611349 | chr17_32937771_+ | SINE | Alu | Name=AluSx1 |
| ADediting_611350 | chr17_32937774_+ | SINE | Alu | Name=AluSx1 |
| ADediting_611351 | chr17_32939163_+ | SINE | Alu | Name=AluSx |
| ADediting_611352 | chr17_32939168_+ | SINE | Alu | Name=AluSx |
| ADediting_611353 | chr17_32939174_+ | SINE | Alu | Name=AluSx |
| ADediting_611354 | chr17_32940474_+ | DNA | hAT-Charlie | Name=MER103C |
| ADediting_611355 | chr17_32944681_+ | SINE | Alu | Name=AluJb |
| ADediting_1546103 | chr17_32937691_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1546104 | chr17_32939152_+ | SINE | Alu | Name=AluSx |
| ADediting_1626935 | chr17_32939260_+ | SINE | Alu | Name=AluSx |
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RNA A-to-I editing events in the alternative splicing sites for TMEM98 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TMEM98 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for TMEM98 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for TMEM98 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000006042.12 | ENST00000579849.6 | TMEM98-206 | hsa-miR-5688 | chr17 | 32942515 | 32942521 | 7mer-m8 | 32942500 | 32942522 | 142 | -13.32 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000006042.12 | ENST00000578289.5 | TMEM98-205 | hsa-miR-4477b | chr17 | 32944955 | 32944961 | 7mer-m8 | 32944942 | 32944962 | 149 | -12.02 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000006042.12 | ENST00000579849.6 | TMEM98-206 | hsa-miR-641 | chr17 | 32942034 | 32942040 | 7mer-m8 | 32942019 | 32942041 | 145 | -15.9 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000006042.12 | ENST00000579849.6 | TMEM98-206 | hsa-miR-641 | chr17 | 32943499 | 32943505 | 7mer-m8 | 32943483 | 32943506 | 157 | -20.85 |
| ADediting_286380 | chr11_79422188_- | ENSG00000006042.12 | ENST00000579849.6 | TMEM98-206 | hsa-miR-5579-3p | chr17 | 32942963 | 32942969 | 7mer-m8 | 32942949 | 32942970 | 147 | -13.6 |
| ADediting_496066 | chr15_66496985_- | ENSG00000006042.12 | ENST00000394642.7 | TMEM98-202 | hsa-miR-4512 | chr17 | 32941020 | 32941026 | 7mer-m8 | 32941006 | 32941027 | 148 | -16.74 |
| ADediting_496066 | chr15_66496985_- | ENSG00000006042.12 | ENST00000579849.6 | TMEM98-206 | hsa-miR-4512 | chr17 | 32941020 | 32941026 | 7mer-m8 | 32941006 | 32941027 | 148 | -16.74 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000006042.12 | ENST00000394642.7 | TMEM98-202 | hsa-miR-4775 | chr17 | 32941311 | 32941317 | 7mer-1a | 32941297 | 32941317 | 140 | -16.98 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000006042.12 | ENST00000579849.6 | TMEM98-206 | hsa-miR-4775 | chr17 | 32941311 | 32941317 | 7mer-1a | 32941297 | 32941317 | 140 | -16.98 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000006042.12 | ENST00000394642.7 | TMEM98-202 | hsa-miR-5585-3p | chr17 | 32941214 | 32941220 | 7mer-m8 | 32941200 | 32941221 | 145 | -12.38 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000006042.12 | ENST00000579849.6 | TMEM98-206 | hsa-miR-5585-3p | chr17 | 32941214 | 32941220 | 7mer-m8 | 32941200 | 32941221 | 145 | -12.38 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1391023 | chr8_140732605_- | ENSG00000006042.12 | ENST00000394642.7 | TMEM98-202 | hsa-miR-151a-3p | chr17 | 32941186 | 32941193 | 8mer-1a | 32941173 | 32941193 | 150 | -17.98 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000006042.12 | ENST00000579849.6 | TMEM98-206 | hsa-miR-151a-3p | chr17 | 32941186 | 32941193 | 8mer-1a | 32941173 | 32941193 | 150 | -17.98 |
| ADediting_496066 | chr15_66496985_- | ENSG00000006042.12 | ENST00000579849.6 | TMEM98-206 | hsa-miR-4512 | chr17 | 32943327 | 32943333 | 7mer-m8 | 32943308 | 32943334 | 142 | -17.74 |
| ADediting_496066 | chr15_66496985_- | ENSG00000006042.12 | ENST00000579849.6 | TMEM98-206 | hsa-miR-4512 | chr17 | 32944211 | 32944217 | 7mer-m8 | 32944195 | 32944218 | 153 | -27.44 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000006042.12 | ENST00000579849.6 | TMEM98-206 | hsa-miR-1273h-3p | chr17 | 32943020 | 32943026 | 7mer-m8 | 32943005 | 32943027 | 153 | -31.16 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000006042.12 | ENST00000394642.7 | TMEM98-202 | hsa-miR-4775 | chr17 | 32941331 | 32941337 | 7mer-m8 | 32941316 | 32941338 | 143 | -8.13 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000006042.12 | ENST00000579849.6 | TMEM98-206 | hsa-miR-4775 | chr17 | 32941331 | 32941337 | 7mer-m8 | 32941316 | 32941338 | 143 | -8.13 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for TMEM98 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for TMEM98 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_611351 | chr17_32939163_+ | 0.226992723596703 | 0.0688144691020061 | 0.609934253683565 | -0.0290869284032042 | 9.35985448072397e-10 | 0.338635293641318 |
| DLPFC | ADediting_611353 | chr17_32939174_+ | 0.0309297038803686 | 0.12259735920036 | 0.878483573803726 | -0.00871872930624883 | 2.11937636690008e-15 | 0.430253469958761 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 2.52584532062085e-08 | 0.309868091842016 | 7.65033619927086e-06 | 0.251079821317764 | 2.33310312122595e-09 | 0.330958149688209 |
| AC | 1.81121287269103e-29 | 0.633621679442713 | 2.11220138953018e-14 | 0.458539547854059 | 1.64616909823873e-36 | 0.68883112704267 |
| PCC | 0.0555859626912328 | 0.138751621391454 | 0.132715766447978 | 0.109179084374697 | 3.60304046154171e-07 | 0.358268995974115 |
| TCX | 0.00907593256203604 | 0.212379324175152 | 0.00185857334282219 | -0.25208193086489 | 2.00125872884913e-21 | 0.676718946120458 |
| FP | 0.000539574781835834 | 0.25680616799062 | 0.00074141939616622 | 0.250594296890743 | 1.69708856612853e-14 | 0.533757969204076 |
| IFG | 0.763984601692145 | 0.0632274065369377 | 0.36035933671642 | -0.19102327877069 | 0.01927596552355 | 0.46465318001626 |
| PG | 6.28909821922909e-08 | 0.38398311757862 | 0.0372091741748068 | 0.152898134655424 | 1.34790980198697e-14 | 0.525507521202752 |
| STG | 0.115053334882952 | 0.173235610810098 | 0.950375866423684 | 0.00689358439960268 | 1.12247039283833e-05 | 0.459067828312886 |
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Relation with AD stages for TMEM98 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 0.00145638230712693 | 0.305383289804264 |
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RelatedDrugs for TMEM98 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM98 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TMEM98 | C4014848 | NANOPHTHALMOS 4 | 1 | CTD_human;UNIPROT |
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