ADeditome: functional annotation of RNA A-to-I editing in AD

Gene summary for MMACHC

Gene summary

Gene information	Gene symbol	MMACHC
	Gene ID	25974
	Gene name	metabolism of cobalamin associated C
	Synonyms	cblC
	Cytomap	1p34.1
	Type of gene	protein-coding
	Description	methylmalonic aciduria and homocystinuria type C proteincyanocobalamin reductase (cyanide-eliminating)methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
	Modification date	20200313
	UniProtAcc	Q9Y4U1,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MMACHC	GO:0006749	glutathione metabolic process	19801555\|22642810
MMACHC	GO:0009235	cobalamin metabolic process	19700356\|22642810
MMACHC	GO:0009236	cobalamin biosynthetic process	19801555
MMACHC	GO:0055114	oxidation-reduction process	19801555
MMACHC	GO:0070988	demethylation	19801555

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RNA A-to-I events for MMACHC

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_118457(45500744, +), ADediting_118458(45502844, +), ADediting_118459(45503323, +), ADediting_118460(45503529, +), ADediting_118461(45504151, +), ADediting_118462(45504172, +), ADediting_118463(45504322, +), ADediting_118464(45504337, +), ADediting_118465(45506684, +), ADediting_118466(45506908, +), ADediting_118467(45507081, +), ADediting_118468(45507121, +), ADediting_118469(45507153, +), ADediting_118470(45509433, +), ADediting_118471(45509437, +), ADediting_118472(45509439, +), ADediting_118473(45509445, +), ADediting_118474(45509453, +), ADediting_118475(45509475, +), ADediting_118476(45509477, +), ADediting_118477(45509484, +), ADediting_118478(45509493, +), ADediting_118479(45509494, +), ADediting_118480(45509514, +), ADediting_118481(45509517, +), ADediting_118482(45509521, +), ADediting_118483(45509530, +), ADediting_118484(45509542, +), ADediting_118485(45509552, +), ADediting_118486(45509578, +), ADediting_118487(45509594, +), ADediting_118488(45509597, +), ADediting_118489(45509599, +), ADediting_118490(45509614, +), ADediting_118491(45509616, +), ADediting_118492(45509623, +), ADediting_118493(45509635, +), ADediting_118494(45509636, +), ADediting_118495(45509651, +), ADediting_118496(45509659, +), ADediting_118497(45509672, +), ADediting_118498(45509673, +), ADediting_118499(45509674, +), ADediting_118500(45509686, +), ADediting_118501(45509688, +), ADediting_118502(45509826, +), ADediting_118503(45509827, +), ADediting_118504(45509832, +), ADediting_118505(45509835, +), ADediting_118506(45509843, +), ADediting_118507(45509853, +), ADediting_118508(45509859, +), ADediting_118509(45509862, +), ADediting_118510(45509865, +), ADediting_118511(45509882, +), ADediting_118512(45509892, +), ADediting_118513(45509894, +), ADediting_118514(45509896, +), ADediting_118515(45509900, +), ADediting_118516(45509901, +), ADediting_118517(45509902, +), ADediting_118518(45509916, +), ADediting_118519(45509917, +), ADediting_118520(45509925, +), ADediting_118521(45509926, +), ADediting_118522(45509930, +), ADediting_118523(45509938, +), ADediting_118524(45509943, +), ADediting_118525(45509948, +), ADediting_118526(45509956, +), ADediting_118527(45509962, +), ADediting_118528(45509966, +), ADediting_118529(45509970, +), ADediting_118530(45509973, +), ADediting_118531(45509992, +), ADediting_118532(45509997, +), ADediting_118533(45509998, +), ADediting_118534(45510001, +), ADediting_118535(45510009, +), ADediting_118536(45510042, +), ADediting_118537(45510059, +), ADediting_118538(45510082, +), ADediting_118539(45510083, +), ADediting_118540(45510085, +), ADediting_118541(45510334, +), ADediting_118542(45510434, +), ADediting_118543(45510440, +), ADediting_118544(45510441, +), ADediting_118545(45510485, +), ADediting_118546(45510548, +), ADediting_1520229(45508804, +), ADediting_1520230(45509488, +), ADediting_1520231(45509570, +), ADediting_1520232(45509692, +), ADediting_1520233(45509871, +), ADediting_1520234(45509918, +), ADediting_1520235(45509920, +), ADediting_1520236(45510005, +), ADediting_1601038(45510086, +),

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RNA editing positional annotations for MMACHC using Annovar

Protein coding RNA editing(s).

ADeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
ADediting_1520229	chr1_45508804_+	synonymous SNV	ENST00000616135.1	c.A267G	p.S89S	.	.	.
ADediting_1520229	chr1_45508804_+	synonymous SNV	ENST00000401061.9	c.A438G	p.S146S	.	.	.

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_118457	chr1_45500744_+	intronic
ADediting_118458	chr1_45502844_+	intronic
ADediting_118459	chr1_45503323_+	intronic
ADediting_118460	chr1_45503529_+	intronic
ADediting_118461	chr1_45504151_+	intronic
ADediting_118462	chr1_45504172_+	intronic
ADediting_118463	chr1_45504322_+	intronic
ADediting_118464	chr1_45504337_+	intronic
ADediting_118465	chr1_45506684_+	intronic
ADediting_118466	chr1_45506908_+	intronic
ADediting_118467	chr1_45507081_+	intronic
ADediting_118468	chr1_45507121_+	intronic
ADediting_118469	chr1_45507153_+	intronic
ADediting_118470	chr1_45509433_+	UTR3
ADediting_118471	chr1_45509437_+	UTR3
ADediting_118472	chr1_45509439_+	UTR3
ADediting_118473	chr1_45509445_+	UTR3
ADediting_118474	chr1_45509453_+	UTR3
ADediting_118475	chr1_45509475_+	UTR3
ADediting_118476	chr1_45509477_+	UTR3
ADediting_118477	chr1_45509484_+	UTR3
ADediting_118478	chr1_45509493_+	UTR3
ADediting_118479	chr1_45509494_+	UTR3
ADediting_118480	chr1_45509514_+	UTR3
ADediting_118481	chr1_45509517_+	UTR3
ADediting_118482	chr1_45509521_+	UTR3
ADediting_118483	chr1_45509530_+	UTR3
ADediting_118484	chr1_45509542_+	UTR3
ADediting_118485	chr1_45509552_+	UTR3
ADediting_118486	chr1_45509578_+	UTR3
ADediting_118487	chr1_45509594_+	UTR3
ADediting_118488	chr1_45509597_+	UTR3
ADediting_118489	chr1_45509599_+	UTR3
ADediting_118490	chr1_45509614_+	UTR3
ADediting_118491	chr1_45509616_+	UTR3
ADediting_118492	chr1_45509623_+	UTR3
ADediting_118493	chr1_45509635_+	UTR3
ADediting_118494	chr1_45509636_+	UTR3
ADediting_118495	chr1_45509651_+	UTR3
ADediting_118496	chr1_45509659_+	UTR3
ADediting_118497	chr1_45509672_+	UTR3
ADediting_118498	chr1_45509673_+	UTR3
ADediting_118499	chr1_45509674_+	UTR3
ADediting_118500	chr1_45509686_+	UTR3
ADediting_118501	chr1_45509688_+	UTR3
ADediting_118502	chr1_45509826_+	UTR3
ADediting_118503	chr1_45509827_+	UTR3
ADediting_118504	chr1_45509832_+	UTR3
ADediting_118505	chr1_45509835_+	UTR3
ADediting_118506	chr1_45509843_+	UTR3
ADediting_118507	chr1_45509853_+	UTR3
ADediting_118508	chr1_45509859_+	UTR3
ADediting_118509	chr1_45509862_+	UTR3
ADediting_118510	chr1_45509865_+	UTR3
ADediting_118511	chr1_45509882_+	UTR3
ADediting_118512	chr1_45509892_+	UTR3
ADediting_118513	chr1_45509894_+	UTR3
ADediting_118514	chr1_45509896_+	UTR3
ADediting_118515	chr1_45509900_+	UTR3
ADediting_118516	chr1_45509901_+	UTR3
ADediting_118517	chr1_45509902_+	UTR3
ADediting_118518	chr1_45509916_+	UTR3
ADediting_118519	chr1_45509917_+	UTR3
ADediting_118520	chr1_45509925_+	UTR3
ADediting_118521	chr1_45509926_+	UTR3
ADediting_118522	chr1_45509930_+	UTR3
ADediting_118523	chr1_45509938_+	UTR3
ADediting_118524	chr1_45509943_+	UTR3
ADediting_118525	chr1_45509948_+	UTR3
ADediting_118526	chr1_45509956_+	UTR3
ADediting_118527	chr1_45509962_+	UTR3
ADediting_118528	chr1_45509966_+	UTR3
ADediting_118529	chr1_45509970_+	UTR3
ADediting_118530	chr1_45509973_+	UTR3
ADediting_118531	chr1_45509992_+	UTR3
ADediting_118532	chr1_45509997_+	UTR3
ADediting_118533	chr1_45509998_+	UTR3
ADediting_118534	chr1_45510001_+	UTR3
ADediting_118535	chr1_45510009_+	UTR3
ADediting_118536	chr1_45510042_+	UTR3
ADediting_118537	chr1_45510059_+	UTR3
ADediting_118538	chr1_45510082_+	UTR3
ADediting_118539	chr1_45510083_+	UTR3
ADediting_118540	chr1_45510085_+	UTR3
ADediting_118541	chr1_45510334_+	UTR3
ADediting_118542	chr1_45510434_+	UTR3
ADediting_118543	chr1_45510440_+	UTR3
ADediting_118544	chr1_45510441_+	UTR3
ADediting_118545	chr1_45510485_+	UTR3
ADediting_118546	chr1_45510548_+	UTR3
ADediting_1520229	chr1_45508804_+	exonic
ADediting_1520230	chr1_45509488_+	UTR3
ADediting_1520231	chr1_45509570_+	UTR3
ADediting_1520232	chr1_45509692_+	UTR3
ADediting_1520233	chr1_45509871_+	UTR3
ADediting_1520234	chr1_45509918_+	UTR3
ADediting_1520235	chr1_45509920_+	UTR3
ADediting_1520236	chr1_45510005_+	UTR3
ADediting_1601038	chr1_45510086_+	UTR3

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_118457	chr1_45500744_+	SINE	Alu	Name=AluSq2
ADediting_118458	chr1_45502844_+	SINE	Alu	Name=AluSp
ADediting_118459	chr1_45503323_+	SINE	Alu	Name=AluSq2
ADediting_118460	chr1_45503529_+	SINE	Alu	Name=AluSx
ADediting_118461	chr1_45504151_+	SINE	Alu	Name=AluSq
ADediting_118462	chr1_45504172_+	SINE	Alu	Name=AluSq
ADediting_118463	chr1_45504322_+	SINE	Alu	Name=AluSq
ADediting_118464	chr1_45504337_+	SINE	Alu	Name=AluSq
ADediting_118465	chr1_45506684_+	SINE	Alu	Name=AluSx
ADediting_118466	chr1_45506908_+	SINE	Alu	Name=AluSz6
ADediting_118467	chr1_45507081_+	SINE	Alu	Name=AluSz6
ADediting_118468	chr1_45507121_+	SINE	Alu	Name=AluSz6
ADediting_118469	chr1_45507153_+	SINE	Alu	Name=AluSz6
ADediting_118470	chr1_45509433_+	SINE	Alu	Name=AluSg7
ADediting_118471	chr1_45509437_+	SINE	Alu	Name=AluSg7
ADediting_118472	chr1_45509439_+	SINE	Alu	Name=AluSg7
ADediting_118473	chr1_45509445_+	SINE	Alu	Name=AluSg7
ADediting_118474	chr1_45509453_+	SINE	Alu	Name=AluSg7
ADediting_118475	chr1_45509475_+	SINE	Alu	Name=AluSg7
ADediting_118476	chr1_45509477_+	SINE	Alu	Name=AluSg7
ADediting_118477	chr1_45509484_+	SINE	Alu	Name=AluSg7
ADediting_118478	chr1_45509493_+	SINE	Alu	Name=AluSg7
ADediting_118479	chr1_45509494_+	SINE	Alu	Name=AluSg7
ADediting_118480	chr1_45509514_+	SINE	Alu	Name=AluSg7
ADediting_118481	chr1_45509517_+	SINE	Alu	Name=AluSg7
ADediting_118482	chr1_45509521_+	SINE	Alu	Name=AluSg7
ADediting_118483	chr1_45509530_+	SINE	Alu	Name=AluSg7
ADediting_118484	chr1_45509542_+	SINE	Alu	Name=AluSg7
ADediting_118485	chr1_45509552_+	SINE	Alu	Name=AluSg7
ADediting_118486	chr1_45509578_+	SINE	Alu	Name=AluSg7
ADediting_118487	chr1_45509594_+	SINE	Alu	Name=AluSg7
ADediting_118488	chr1_45509597_+	SINE	Alu	Name=AluSg7
ADediting_118489	chr1_45509599_+	SINE	Alu	Name=AluSg7
ADediting_118490	chr1_45509614_+	SINE	Alu	Name=AluSg7
ADediting_118491	chr1_45509616_+	SINE	Alu	Name=AluSg7
ADediting_118492	chr1_45509623_+	SINE	Alu	Name=AluSg7
ADediting_118493	chr1_45509635_+	SINE	Alu	Name=AluSg7
ADediting_118494	chr1_45509636_+	SINE	Alu	Name=AluSg7
ADediting_118495	chr1_45509651_+	SINE	Alu	Name=AluSg7
ADediting_118496	chr1_45509659_+	SINE	Alu	Name=AluSg7
ADediting_118497	chr1_45509672_+	SINE	Alu	Name=AluSg7
ADediting_118498	chr1_45509673_+	SINE	Alu	Name=AluSg7
ADediting_118499	chr1_45509674_+	SINE	Alu	Name=AluSg7
ADediting_118500	chr1_45509686_+	SINE	Alu	Name=AluSg7
ADediting_118501	chr1_45509688_+	SINE	Alu	Name=AluSg7
ADediting_118502	chr1_45509826_+	SINE	Alu	Name=AluSx4
ADediting_118503	chr1_45509827_+	SINE	Alu	Name=AluSx4
ADediting_118504	chr1_45509832_+	SINE	Alu	Name=AluSx4
ADediting_118505	chr1_45509835_+	SINE	Alu	Name=AluSx4
ADediting_118506	chr1_45509843_+	SINE	Alu	Name=AluSx4
ADediting_118507	chr1_45509853_+	SINE	Alu	Name=AluSx4
ADediting_118508	chr1_45509859_+	SINE	Alu	Name=AluSx4
ADediting_118509	chr1_45509862_+	SINE	Alu	Name=AluSx4
ADediting_118510	chr1_45509865_+	SINE	Alu	Name=AluSx4
ADediting_118511	chr1_45509882_+	SINE	Alu	Name=AluSx4
ADediting_118512	chr1_45509892_+	SINE	Alu	Name=AluSx4
ADediting_118513	chr1_45509894_+	SINE	Alu	Name=AluSx4
ADediting_118514	chr1_45509896_+	SINE	Alu	Name=AluSx4
ADediting_118515	chr1_45509900_+	SINE	Alu	Name=AluSx4
ADediting_118516	chr1_45509901_+	SINE	Alu	Name=AluSx4
ADediting_118517	chr1_45509902_+	SINE	Alu	Name=AluSx4
ADediting_118518	chr1_45509916_+	SINE	Alu	Name=AluSx4
ADediting_118519	chr1_45509917_+	SINE	Alu	Name=AluSx4
ADediting_118520	chr1_45509925_+	SINE	Alu	Name=AluSx4
ADediting_118521	chr1_45509926_+	SINE	Alu	Name=AluSx4
ADediting_118522	chr1_45509930_+	SINE	Alu	Name=AluSx4
ADediting_118523	chr1_45509938_+	SINE	Alu	Name=AluSx4
ADediting_118524	chr1_45509943_+	SINE	Alu	Name=AluSx4
ADediting_118525	chr1_45509948_+	SINE	Alu	Name=AluSx4
ADediting_118526	chr1_45509956_+	SINE	Alu	Name=AluSx4
ADediting_118527	chr1_45509962_+	SINE	Alu	Name=AluSx4
ADediting_118528	chr1_45509966_+	SINE	Alu	Name=AluSx4
ADediting_118529	chr1_45509970_+	SINE	Alu	Name=AluSx4
ADediting_118530	chr1_45509973_+	SINE	Alu	Name=AluSx4
ADediting_118531	chr1_45509992_+	SINE	Alu	Name=AluSx4
ADediting_118532	chr1_45509997_+	SINE	Alu	Name=AluSx4
ADediting_118533	chr1_45509998_+	SINE	Alu	Name=AluSx4
ADediting_118534	chr1_45510001_+	SINE	Alu	Name=AluSx4
ADediting_118535	chr1_45510009_+	SINE	Alu	Name=AluSx4
ADediting_118536	chr1_45510042_+	SINE	Alu	Name=AluSx4
ADediting_118537	chr1_45510059_+	SINE	Alu	Name=AluSx4
ADediting_118538	chr1_45510082_+	SINE	Alu	Name=AluSx4
ADediting_118539	chr1_45510083_+	SINE	Alu	Name=AluSx4
ADediting_118540	chr1_45510085_+	SINE	Alu	Name=AluSx4
ADediting_118542	chr1_45510434_+	SINE	Alu	Name=AluJr
ADediting_118543	chr1_45510440_+	SINE	Alu	Name=AluJr
ADediting_118544	chr1_45510441_+	SINE	Alu	Name=AluJr
ADediting_118545	chr1_45510485_+	SINE	Alu	Name=AluJr
ADediting_1520230	chr1_45509488_+	SINE	Alu	Name=AluSg7
ADediting_1520231	chr1_45509570_+	SINE	Alu	Name=AluSg7
ADediting_1520232	chr1_45509692_+	SINE	Alu	Name=AluSg7
ADediting_1520233	chr1_45509871_+	SINE	Alu	Name=AluSx4
ADediting_1520234	chr1_45509918_+	SINE	Alu	Name=AluSx4
ADediting_1520235	chr1_45509920_+	SINE	Alu	Name=AluSx4
ADediting_1520236	chr1_45510005_+	SINE	Alu	Name=AluSx4
ADediting_1601038	chr1_45510086_+	SINE	Alu	Name=AluSx4

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RNA A-to-I editing events in the alternative splicing sites for MMACHC

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	ADeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
A3SS	ADediting_1520229	chr1_45508804_+	45508786:45508808	3ss	2i	CTCTCCCCAGCGCATATCAGGTG	0.32	CTCTCCCCAGCGCATATCGGGTG	-7.63

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MMACHC

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

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Protein coding region RNA A-to-I editings for MMACHC

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for MMACHC

RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_118470	chr1_45509433_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3613-3p	chr1	45509426	45509432	7mer-m8	45509410	45509433	169	-10.17
ADediting_118472	chr1_45509439_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-10a-5p	chr1	45509434	45509440	7mer-m8	45509419	45509441	141	-11.43
ADediting_118472	chr1_45509439_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-10b-5p	chr1	45509434	45509440	7mer-m8	45509419	45509441	149	-11.5
ADediting_118472	chr1_45509439_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-339-5p	chr1	45509433	45509439	7mer-m8	45509419	45509440	143	-14.31
ADediting_118472	chr1_45509439_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3667-5p	chr1	45509437	45509444	8mer-1a	45509422	45509444	155	-18.3
ADediting_118472	chr1_45509439_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4725-5p	chr1	45509435	45509441	7mer-m8	45509422	45509442	140	-15.96
ADediting_118472	chr1_45509439_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-504-5p	chr1	45509435	45509441	7mer-m8	45509422	45509442	149	-18.8
ADediting_118472	chr1_45509439_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-5699-3p	chr1	45509432	45509438	7mer-m8	45509418	45509439	140	-16.12
ADediting_118473	chr1_45509445_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-451b	chr1	45509440	45509446	7mer-m8	45509426	45509447	140	-8.32
ADediting_118473	chr1_45509445_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4696	chr1	45509439	45509445	7mer-m8	45509429	45509446	144	-17.45
ADediting_118473	chr1_45509445_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6501-3p	chr1	45509443	45509449	7mer-m8	45509426	45509450	147	-14.86
ADediting_118477	chr1_45509484_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4468	chr1	45509480	45509487	8mer-1a	45509471	45509487	146	-13.78
ADediting_118479	chr1_45509494_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-485-5p	chr1	45509491	45509497	7mer-m8	45509478	45509498	153	-19.67
ADediting_118479	chr1_45509494_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6884-5p	chr1	45509491	45509497	7mer-m8	45509476	45509498	147	-22.01
ADediting_118482	chr1_45509521_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3166	chr1	45509519	45509525	7mer-m8	45509504	45509526	154	-18.06
ADediting_118482	chr1_45509521_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-7849-3p	chr1	45509515	45509521	7mer-m8	45509500	45509522	166	-21.86
ADediting_118483	chr1_45509530_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6089	chr1	45509528	45509534	7mer-m8	45509512	45509535	159	-33.66
ADediting_118484	chr1_45509542_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4691-3p	chr1	45509539	45509545	7mer-m8	45509519	45509546	150	-26.73
ADediting_118485	chr1_45509552_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4722-3p	chr1	45509549	45509555	7mer-m8	45509537	45509556	145	-23.37
ADediting_118485	chr1_45509552_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4769-3p	chr1	45509548	45509554	7mer-m8	45509534	45509555	159	-21.65
ADediting_118485	chr1_45509552_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6727-3p	chr1	45509549	45509555	7mer-m8	45509537	45509556	150	-20.51
ADediting_118485	chr1_45509552_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6817-5p	chr1	45509548	45509554	7mer-m8	45509529	45509555	147	-25.38
ADediting_118486	chr1_45509578_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3157-5p	chr1	45509572	45509578	7mer-m8	45509556	45509579	169	-27.24
ADediting_118486	chr1_45509578_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-34a-3p	chr1	45509574	45509580	7mer-m8	45509559	45509581	159	-9.31
ADediting_118492	chr1_45509623_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3940-3p	chr1	45509620	45509626	7mer-m8	45509606	45509627	140	-22.76
ADediting_118494	chr1_45509636_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-28-5p	chr1	45509634	45509640	7mer-m8	45509621	45509641	151	-18.7
ADediting_118494	chr1_45509636_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3139	chr1	45509634	45509640	7mer-m8	45509619	45509641	165	-23.25
ADediting_118494	chr1_45509636_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4633-3p	chr1	45509633	45509639	7mer-m8	45509616	45509640	146	-21.78
ADediting_118494	chr1_45509636_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-610	chr1	45509632	45509638	7mer-m8	45509618	45509639	154	-16.27
ADediting_118494	chr1_45509636_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6500-5p	chr1	45509633	45509639	7mer-m8	45509615	45509640	147	-21.92
ADediting_118494	chr1_45509636_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-708-5p	chr1	45509634	45509640	7mer-m8	45509620	45509641	154	-22.05
ADediting_118495	chr1_45509651_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4776-5p	chr1	45509648	45509654	7mer-m8	45509634	45509655	164	-27.73
ADediting_118495	chr1_45509651_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4800-5p	chr1	45509649	45509655	7mer-m8	45509633	45509656	155	-24.83
ADediting_118496	chr1_45509659_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-483-5p	chr1	45509655	45509661	7mer-m8	45509640	45509662	154	-24
ADediting_118497	chr1_45509672_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6771-5p	chr1	45509666	45509673	8mer-1a	45509652	45509673	155	-26.64
ADediting_118498	chr1_45509673_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3192-5p	chr1	45509666	45509673	8mer-1a	45509650	45509673	152	-28.02
ADediting_118498	chr1_45509673_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-326	chr1	45509668	45509674	7mer-m8	45509656	45509675	140	-14.14
ADediting_118498	chr1_45509673_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-330-5p	chr1	45509668	45509674	7mer-m8	45509654	45509675	140	-19.02
ADediting_118498	chr1_45509673_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4314	chr1	45509667	45509673	7mer-m8	45509657	45509674	140	-19.14
ADediting_118498	chr1_45509673_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4522	chr1	45509670	45509676	7mer-m8	45509660	45509677	151	-21
ADediting_118498	chr1_45509673_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-514a-5p	chr1	45509669	45509675	7mer-m8	45509656	45509676	154	-18.58
ADediting_118499	chr1_45509674_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3189-3p	chr1	45509668	45509674	7mer-m8	45509651	45509675	147	-24.2
ADediting_118499	chr1_45509674_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-659-5p	chr1	45509671	45509677	7mer-m8	45509658	45509678	146	-21.67
ADediting_118499	chr1_45509674_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6813-3p	chr1	45509669	45509675	7mer-m8	45509656	45509676	140	-11.95
ADediting_118502	chr1_45509826_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-513a-5p	chr1	45509820	45509826	7mer-m8	45509810	45509827	152	-20.34
ADediting_118502	chr1_45509826_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-638	chr1	45509825	45509831	7mer-1a	45509807	45509831	167	-42.95
ADediting_118503	chr1_45509827_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-8052	chr1	45509825	45509831	7mer-1a	45509810	45509831	141	-24.5
ADediting_118504	chr1_45509832_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-371a-3p	chr1	45509830	45509836	7mer-m8	45509815	45509837	144	-13.78
ADediting_118506	chr1_45509843_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-10392-3p	chr1	45509841	45509848	8mer-1a	45509824	45509848	144	-24.04
ADediting_118506	chr1_45509843_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-361-3p	chr1	45509837	45509843	7mer-m8	45509824	45509844	153	-25.1
ADediting_118508	chr1_45509859_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-1180-5p	chr1	45509854	45509861	8mer-1a	45509840	45509861	155	-27.02
ADediting_118508	chr1_45509859_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-7114-3p	chr1	45509854	45509861	8mer-1a	45509841	45509861	159	-27.21
ADediting_118512	chr1_45509892_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-193a-3p	chr1	45509886	45509893	8mer-1a	45509872	45509893	144	-17.47
ADediting_118512	chr1_45509892_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-193b-3p	chr1	45509886	45509893	8mer-1a	45509872	45509893	140	-15.7
ADediting_118512	chr1_45509892_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3190-5p	chr1	45509885	45509891	7mer-m8	45509873	45509892	154	-20.25
ADediting_118513	chr1_45509894_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-20a-3p	chr1	45509890	45509896	7mer-m8	45509876	45509897	140	-11.91
ADediting_118513	chr1_45509894_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-217-5p	chr1	45509891	45509897	7mer-m8	45509874	45509898	144	-19.69
ADediting_118513	chr1_45509894_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-33a-5p	chr1	45509889	45509895	7mer-m8	45509876	45509896	140	-10.7
ADediting_118513	chr1_45509894_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-33b-5p	chr1	45509889	45509895	7mer-m8	45509877	45509896	140	-10.75
ADediting_118513	chr1_45509894_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6807-3p	chr1	45509891	45509897	7mer-m8	45509874	45509898	159	-22.66
ADediting_118515	chr1_45509900_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-23a-5p	chr1	45509898	45509904	7mer-m8	45509884	45509905	150	-21.85
ADediting_118515	chr1_45509900_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-23b-5p	chr1	45509898	45509904	7mer-m8	45509876	45509905	142	-22.32
ADediting_118515	chr1_45509900_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6509-3p	chr1	45509894	45509901	8mer-1a	45509880	45509901	140	-13.78
ADediting_118516	chr1_45509901_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-1304-3p	chr1	45509894	45509901	8mer-1a	45509880	45509901	150	-20.12
ADediting_118517	chr1_45509902_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4508	chr1	45509900	45509906	7mer-m8	45509891	45509907	140	-21.04
ADediting_118517	chr1_45509902_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6837-3p	chr1	45509895	45509901	7mer-m8	45509877	45509902	155	-20.7
ADediting_118518	chr1_45509916_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-222-5p	chr1	45509910	45509917	8mer-1a	45509896	45509917	140	-9.13
ADediting_118518	chr1_45509916_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-30a-3p	chr1	45509912	45509919	8mer-1a	45509895	45509919	150	-12.23
ADediting_118518	chr1_45509916_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-30d-3p	chr1	45509912	45509919	8mer-1a	45509893	45509919	150	-16.61
ADediting_118518	chr1_45509916_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-30e-3p	chr1	45509912	45509919	8mer-1a	45509895	45509919	150	-14.38
ADediting_118518	chr1_45509916_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-936	chr1	45509909	45509916	8mer-1a	45509894	45509916	159	-22.3
ADediting_118519	chr1_45509917_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-325	chr1	45509910	45509917	8mer-1a	45509895	45509917	141	-9.82
ADediting_118520	chr1_45509925_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-20a-3p	chr1	45509918	45509925	8mer-1a	45509904	45509925	151	-10.59
ADediting_118521	chr1_45509926_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3200-3p	chr1	45509921	45509927	7mer-m8	45509907	45509928	143	-11.73
ADediting_118521	chr1_45509926_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6841-3p	chr1	45509920	45509926	7mer-m8	45509907	45509927	147	-13.98
ADediting_118525	chr1_45509948_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4747-3p	chr1	45509946	45509952	7mer-m8	45509932	45509953	164	-28.66
ADediting_118526	chr1_45509956_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-140-3p	chr1	45509951	45509957	7mer-m8	45509938	45509958	151	-18.59
ADediting_118528	chr1_45509966_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-1207-3p	chr1	45509959	45509965	7mer-m8	45509948	45509966	145	-13.82
ADediting_118528	chr1_45509966_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-646	chr1	45509961	45509967	7mer-m8	45509949	45509968	148	-21.05
ADediting_118530	chr1_45509973_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-125a-5p	chr1	45509966	45509972	7mer-m8	45509950	45509973	142	-17.93
ADediting_118530	chr1_45509973_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-125b-5p	chr1	45509966	45509972	7mer-m8	45509952	45509973	141	-16.47
ADediting_118530	chr1_45509973_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3943	chr1	45509970	45509976	7mer-m8	45509957	45509977	150	-22.11
ADediting_118530	chr1_45509973_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4313	chr1	45509969	45509975	7mer-m8	45509957	45509976	146	-21.1
ADediting_118530	chr1_45509973_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4319	chr1	45509966	45509972	7mer-m8	45509957	45509973	142	-17.68
ADediting_118532	chr1_45509997_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-7152-3p	chr1	45509995	45510001	7mer-m8	45509983	45510002	140	-16.13
ADediting_118533	chr1_45509998_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-149-5p	chr1	45509995	45510001	7mer-m8	45509979	45510002	151	-21.39
ADediting_118533	chr1_45509998_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-372-5p	chr1	45509991	45509997	7mer-m8	45509976	45509998	145	-12.33
ADediting_118534	chr1_45510001_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-671-3p	chr1	45509995	45510001	7mer-m8	45509982	45510002	151	-19.43
ADediting_118534	chr1_45510001_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6763-3p	chr1	45509998	45510004	7mer-m8	45509985	45510005	140	-22.64
ADediting_118535	chr1_45510009_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-1281	chr1	45510002	45510008	7mer-m8	45509993	45510009	141	-17.27
ADediting_118541	chr1_45510334_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-125a-5p	chr1	45510329	45510335	7mer-m8	45510313	45510336	147	-18.02
ADediting_118541	chr1_45510334_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-125b-5p	chr1	45510329	45510335	7mer-m8	45510315	45510336	147	-18.02
ADediting_118541	chr1_45510334_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-210-5p	chr1	45510331	45510337	7mer-m8	45510315	45510338	142	-17.51
ADediting_118541	chr1_45510334_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4319	chr1	45510329	45510335	7mer-m8	45510319	45510336	148	-18.89
ADediting_118541	chr1_45510334_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4649-3p	chr1	45510327	45510333	7mer-m8	45510314	45510334	145	-17.38
ADediting_118541	chr1_45510334_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-544b	chr1	45510328	45510334	7mer-m8	45510311	45510335	149	-16.4
ADediting_118543	chr1_45510440_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-513a-5p	chr1	45510434	45510440	7mer-m8	45510424	45510441	152	-22.25
ADediting_118543	chr1_45510440_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-638	chr1	45510439	45510445	7mer-1a	45510421	45510445	157	-33.44
ADediting_118545	chr1_45510485_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3938	chr1	45510483	45510489	7mer-m8	45510469	45510490	140	-16.05
ADediting_118545	chr1_45510485_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6747-3p	chr1	45510479	45510485	7mer-m8	45510459	45510486	143	-32.47
ADediting_118545	chr1_45510485_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6752-3p	chr1	45510480	45510487	8mer-1a	45510467	45510487	142	-20.64
ADediting_118546	chr1_45510548_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6512-3p	chr1	45510543	45510550	8mer-1a	45510528	45510550	147	-20
ADediting_118546	chr1_45510548_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6720-5p	chr1	45510543	45510550	8mer-1a	45510528	45510550	158	-20.25
ADediting_118546	chr1_45510548_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6849-3p	chr1	45510542	45510549	8mer-1a	45510529	45510549	141	-13.76
ADediting_118546	chr1_45510548_+	ENSG00000132763.15	ENST00000616135.1	MMACHC-203	hsa-miR-6512-3p	chr1	45510543	45510550	8mer-1a	45510528	45510550	147	-20
ADediting_118546	chr1_45510548_+	ENSG00000132763.15	ENST00000616135.1	MMACHC-203	hsa-miR-6720-5p	chr1	45510543	45510550	8mer-1a	45510528	45510550	158	-20.25
ADediting_118546	chr1_45510548_+	ENSG00000132763.15	ENST00000616135.1	MMACHC-203	hsa-miR-6849-3p	chr1	45510542	45510549	8mer-1a	45510529	45510549	141	-13.76
ADediting_1520232	chr1_45509692_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-483-3p	chr1	45509687	45509694	8mer-1a	45509674	45509694	157	-21.42
ADediting_1520235	chr1_45509920_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4325	chr1	45509917	45509924	8mer-1a	45509907	45509924	143	-12.13
ADediting_1520236	chr1_45510005_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-1913	chr1	45510003	45510010	8mer-1a	45509989	45510010	147	-21.73
ADediting_1520236	chr1_45510005_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-331-3p	chr1	45509998	45510004	7mer-m8	45509985	45510005	141	-16.58

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_118471	chr1_45509437_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3664-5p	chr1	45509434	45509440	7mer-m8	45509420	45509441	150	-14.83
ADediting_118471	chr1_45509437_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4522	chr1	45509435	45509441	7mer-m8	45509422	45509442	152	-14.23
ADediting_118471	chr1_45509437_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6888-3p	chr1	45509432	45509438	7mer-m8	45509419	45509439	143	-9.14
ADediting_118472	chr1_45509439_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3664-5p	chr1	45509434	45509440	7mer-m8	45509420	45509441	150	-14.83
ADediting_118472	chr1_45509439_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4432	chr1	45509437	45509444	8mer-1a	45509424	45509444	154	-14.4
ADediting_118472	chr1_45509439_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4522	chr1	45509435	45509441	7mer-m8	45509422	45509442	152	-14.23
ADediting_118472	chr1_45509439_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6888-3p	chr1	45509432	45509438	7mer-m8	45509419	45509439	143	-9.14
ADediting_118473	chr1_45509445_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-499a-5p	chr1	45509438	45509444	7mer-m8	45509425	45509445	141	-8.16
ADediting_118475	chr1_45509475_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-1227-3p	chr1	45509469	45509476	8mer-1a	45509457	45509476	148	-18.2
ADediting_118476	chr1_45509477_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-873-3p	chr1	45509475	45509481	7mer-m8	45509456	45509482	141	-22.88
ADediting_118477	chr1_45509484_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6832-5p	chr1	45509478	45509484	7mer-m8	45509463	45509485	140	-17.32
ADediting_118477	chr1_45509484_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6869-5p	chr1	45509481	45509487	7mer-m8	45509466	45509488	154	-23.16
ADediting_118478	chr1_45509493_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-377-5p	chr1	45509491	45509497	7mer-m8	45509477	45509498	155	-18.38
ADediting_118478	chr1_45509493_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6086	chr1	45509491	45509497	7mer-m8	45509479	45509498	150	-20.42
ADediting_118478	chr1_45509493_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6516-5p	chr1	45509487	45509493	7mer-m8	45509469	45509494	147	-13.95
ADediting_118479	chr1_45509494_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-377-5p	chr1	45509491	45509497	7mer-m8	45509477	45509498	155	-18.38
ADediting_118479	chr1_45509494_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6086	chr1	45509491	45509497	7mer-m8	45509479	45509498	150	-20.42
ADediting_118479	chr1_45509494_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6516-5p	chr1	45509487	45509493	7mer-m8	45509469	45509494	147	-13.95
ADediting_118481	chr1_45509517_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-302f	chr1	45509513	45509520	8mer-1a	45509504	45509520	145	-10.96
ADediting_118483	chr1_45509530_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3929	chr1	45509527	45509533	7mer-m8	45509512	45509534	153	-19.03
ADediting_118483	chr1_45509530_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4478	chr1	45509527	45509533	7mer-m8	45509517	45509534	148	-19.55
ADediting_118483	chr1_45509530_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4649-3p	chr1	45509524	45509530	7mer-m8	45509511	45509531	140	-12.17
ADediting_118483	chr1_45509530_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-485-5p	chr1	45509528	45509534	7mer-m8	45509514	45509535	153	-18.24
ADediting_118483	chr1_45509530_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-7160-5p	chr1	45509525	45509531	7mer-m8	45509512	45509532	141	-18.59
ADediting_118484	chr1_45509542_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-5690	chr1	45509539	45509545	7mer-m8	45509526	45509546	145	-17.72
ADediting_118485	chr1_45509552_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-215-3p	chr1	45509548	45509554	7mer-m8	45509533	45509555	147	-21.35
ADediting_118488	chr1_45509597_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3675-3p	chr1	45509595	45509601	7mer-m8	45509581	45509602	145	-12.58
ADediting_118489	chr1_45509599_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3675-3p	chr1	45509595	45509601	7mer-m8	45509581	45509602	145	-12.58
ADediting_118490	chr1_45509614_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-1272	chr1	45509608	45509615	8mer-1a	45509592	45509615	148	-15.96
ADediting_118492	chr1_45509623_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3190-5p	chr1	45509617	45509623	7mer-m8	45509606	45509624	144	-16.24
ADediting_118492	chr1_45509623_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-548s	chr1	45509616	45509622	7mer-m8	45509602	45509623	143	-10.86
ADediting_118493	chr1_45509635_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4424	chr1	45509632	45509638	7mer-m8	45509616	45509639	143	-12.87
ADediting_118494	chr1_45509636_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4424	chr1	45509632	45509638	7mer-m8	45509616	45509639	143	-12.87
ADediting_118496	chr1_45509659_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4426	chr1	45509656	45509662	7mer-m8	45509647	45509663	141	-8.49
ADediting_118496	chr1_45509659_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4647	chr1	45509656	45509662	7mer-m8	45509641	45509663	150	-18.54
ADediting_118496	chr1_45509659_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4662b	chr1	45509656	45509662	7mer-m8	45509642	45509663	140	-10.63
ADediting_118497	chr1_45509672_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-30b-3p	chr1	45509665	45509672	8mer-1a	45509649	45509672	149	-18.3
ADediting_118497	chr1_45509672_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3689a-3p	chr1	45509665	45509672	8mer-1a	45509651	45509672	149	-21.92
ADediting_118497	chr1_45509672_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3689b-3p	chr1	45509665	45509672	8mer-1a	45509651	45509672	149	-21.97
ADediting_118497	chr1_45509672_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3689c	chr1	45509665	45509672	8mer-1a	45509651	45509672	149	-21.97
ADediting_118497	chr1_45509672_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6779-5p	chr1	45509665	45509672	8mer-1a	45509649	45509672	151	-22.6
ADediting_118497	chr1_45509672_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-887-5p	chr1	45509666	45509673	8mer-1a	45509653	45509673	147	-15.68
ADediting_118498	chr1_45509673_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-887-5p	chr1	45509666	45509673	8mer-1a	45509653	45509673	147	-15.68
ADediting_118499	chr1_45509674_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-8083	chr1	45509672	45509678	7mer-m8	45509659	45509679	143	-19.24
ADediting_118501	chr1_45509688_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-7152-5p	chr1	45509685	45509691	7mer-m8	45509671	45509692	151	-16.69
ADediting_118502	chr1_45509826_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-10399-5p	chr1	45509821	45509827	7mer-m8	45509808	45509828	140	-9.22
ADediting_118502	chr1_45509826_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6504-3p	chr1	45509821	45509827	7mer-m8	45509807	45509828	148	-14.48
ADediting_118502	chr1_45509826_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-7151-3p	chr1	45509819	45509826	8mer-1a	45509806	45509826	152	-18.13
ADediting_118503	chr1_45509827_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-10399-5p	chr1	45509821	45509827	7mer-m8	45509808	45509828	140	-9.22
ADediting_118503	chr1_45509827_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-5089-5p	chr1	45509825	45509831	7mer-m8	45509810	45509832	145	-13.34
ADediting_118503	chr1_45509827_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6504-3p	chr1	45509821	45509827	7mer-m8	45509807	45509828	148	-14.48
ADediting_118504	chr1_45509832_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-5089-5p	chr1	45509825	45509831	7mer-m8	45509810	45509832	145	-13.34
ADediting_118504	chr1_45509832_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-512-3p	chr1	45509830	45509836	7mer-m8	45509816	45509837	149	-15.5
ADediting_118504	chr1_45509832_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6506-5p	chr1	45509826	45509832	7mer-m8	45509811	45509833	144	-14.98
ADediting_118505	chr1_45509835_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-512-3p	chr1	45509830	45509836	7mer-m8	45509816	45509837	149	-15.5
ADediting_118505	chr1_45509835_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-759	chr1	45509833	45509839	7mer-m8	45509819	45509840	145	-14.48
ADediting_118506	chr1_45509843_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6778-3p	chr1	45509839	45509845	7mer-m8	45509826	45509846	147	-15.69
ADediting_118507	chr1_45509853_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6747-3p	chr1	45509848	45509854	7mer-m8	45509834	45509855	150	-25.36
ADediting_118508	chr1_45509859_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-640	chr1	45509855	45509861	7mer-m8	45509846	45509862	154	-26.45
ADediting_118509	chr1_45509862_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-640	chr1	45509855	45509861	7mer-m8	45509846	45509862	154	-26.45
ADediting_118511	chr1_45509882_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3663-5p	chr1	45509876	45509882	7mer-m8	45509863	45509883	140	-24.99
ADediting_118511	chr1_45509882_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6131	chr1	45509877	45509883	7mer-m8	45509864	45509884	143	-18.2
ADediting_118511	chr1_45509882_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6843-3p	chr1	45509875	45509881	7mer-m8	45509862	45509882	146	-16.77
ADediting_118511	chr1_45509882_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6848-3p	chr1	45509875	45509881	7mer-m8	45509860	45509882	143	-18.78
ADediting_118512	chr1_45509892_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4742-3p	chr1	45509890	45509896	7mer-m8	45509877	45509897	145	-13.7
ADediting_118513	chr1_45509894_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4742-3p	chr1	45509890	45509896	7mer-m8	45509877	45509897	145	-13.7
ADediting_118514	chr1_45509896_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4742-3p	chr1	45509890	45509896	7mer-m8	45509877	45509897	145	-13.7
ADediting_118516	chr1_45509901_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-193b-5p	chr1	45509899	45509905	7mer-m8	45509885	45509906	142	-19.59
ADediting_118517	chr1_45509902_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-193b-5p	chr1	45509899	45509905	7mer-m8	45509885	45509906	142	-19.59
ADediting_118519	chr1_45509917_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-153-5p	chr1	45509915	45509921	7mer-m8	45509900	45509922	144	-8.17
ADediting_118520	chr1_45509925_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3680-3p	chr1	45509919	45509925	7mer-m8	45509904	45509926	140	-14.39
ADediting_118521	chr1_45509926_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3680-3p	chr1	45509919	45509925	7mer-m8	45509904	45509926	140	-14.39
ADediting_118523	chr1_45509938_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6872-3p	chr1	45509934	45509940	7mer-m8	45509920	45509941	142	-15.02
ADediting_118525	chr1_45509948_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-1539	chr1	45509943	45509949	7mer-m8	45509933	45509950	150	-25.96
ADediting_118525	chr1_45509948_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-191-3p	chr1	45509942	45509948	7mer-m8	45509927	45509949	146	-20.16
ADediting_118526	chr1_45509956_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-7151-3p	chr1	45509949	45509955	7mer-m8	45509936	45509956	143	-20.23
ADediting_118528	chr1_45509966_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6869-5p	chr1	45509963	45509969	7mer-m8	45509947	45509970	152	-21.14
ADediting_118529	chr1_45509970_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-1200	chr1	45509966	45509972	7mer-m8	45509952	45509973	141	-18.61
ADediting_118529	chr1_45509970_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6869-5p	chr1	45509963	45509969	7mer-m8	45509947	45509970	152	-21.14
ADediting_118530	chr1_45509973_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-1200	chr1	45509966	45509972	7mer-m8	45509952	45509973	141	-18.61
ADediting_118530	chr1_45509973_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6791-3p	chr1	45509969	45509975	7mer-m8	45509956	45509976	154	-17.64
ADediting_118530	chr1_45509973_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6829-3p	chr1	45509969	45509975	7mer-m8	45509957	45509976	155	-20.58
ADediting_118532	chr1_45509997_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-607	chr1	45509991	45509997	7mer-m8	45509980	45509998	145	-11.64
ADediting_118533	chr1_45509998_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-607	chr1	45509991	45509997	7mer-m8	45509980	45509998	145	-11.64
ADediting_118534	chr1_45510001_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-7113-3p	chr1	45509999	45510005	7mer-m8	45509984	45510006	140	-18.83
ADediting_118535	chr1_45510009_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-5001-3p	chr1	45510004	45510010	7mer-m8	45509987	45510011	153	-20.4
ADediting_118535	chr1_45510009_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6836-3p	chr1	45510002	45510008	7mer-m8	45509989	45510009	145	-19.32
ADediting_118536	chr1_45510042_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3944-5p	chr1	45510036	45510042	7mer-m8	45510023	45510043	149	-15.96
ADediting_118536	chr1_45510042_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-7156-3p	chr1	45510035	45510041	7mer-m8	45510014	45510042	148	-25.2
ADediting_118537	chr1_45510059_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6760-3p	chr1	45510055	45510061	7mer-m8	45510042	45510062	148	-19.47
ADediting_118537	chr1_45510059_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6773-3p	chr1	45510053	45510059	7mer-m8	45510039	45510060	142	-14.97
ADediting_118541	chr1_45510334_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-4780	chr1	45510330	45510336	7mer-m8	45510316	45510337	154	-17.59
ADediting_118541	chr1_45510334_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6851-3p	chr1	45510332	45510338	7mer-m8	45510319	45510339	142	-14.11
ADediting_118542	chr1_45510434_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-125a-3p	chr1	45510431	45510437	7mer-m8	45510417	45510438	149	-23.27
ADediting_118542	chr1_45510434_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-552-3p	chr1	45510432	45510439	8mer-1a	45510419	45510439	148	-17.31
ADediting_118543	chr1_45510440_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-10399-5p	chr1	45510435	45510441	7mer-m8	45510419	45510442	149	-15.29
ADediting_118543	chr1_45510440_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6504-3p	chr1	45510435	45510441	7mer-m8	45510423	45510442	146	-12.87
ADediting_118544	chr1_45510441_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-10399-5p	chr1	45510435	45510441	7mer-m8	45510419	45510442	149	-15.29
ADediting_118544	chr1_45510441_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-5089-5p	chr1	45510439	45510445	7mer-m8	45510426	45510446	151	-20.46
ADediting_118544	chr1_45510441_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6504-3p	chr1	45510435	45510441	7mer-m8	45510423	45510442	146	-12.87
ADediting_118545	chr1_45510485_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-1915-5p	chr1	45510480	45510487	8mer-1a	45510464	45510487	152	-22.36
ADediting_118545	chr1_45510485_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3152-5p	chr1	45510478	45510484	7mer-m8	45510464	45510485	142	-15.92
ADediting_118545	chr1_45510485_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-502-5p	chr1	45510481	45510488	8mer-1a	45510470	45510488	150	-20.05
ADediting_118546	chr1_45510548_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-1287-3p	chr1	45510543	45510550	8mer-1a	45510529	45510550	142	-14.58
ADediting_118546	chr1_45510548_+	ENSG00000132763.15	ENST00000616135.1	MMACHC-203	hsa-miR-1287-3p	chr1	45510543	45510550	8mer-1a	45510529	45510550	142	-14.58
ADediting_1520230	chr1_45509488_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6869-5p	chr1	45509481	45509487	7mer-m8	45509466	45509488	154	-23.16
ADediting_1520231	chr1_45509570_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-3934-5p	chr1	45509567	45509573	7mer-m8	45509555	45509574	149	-23.88
ADediting_1520232	chr1_45509692_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6758-3p	chr1	45509689	45509695	7mer-m8	45509678	45509696	146	-14.95
ADediting_1520232	chr1_45509692_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-7152-5p	chr1	45509685	45509691	7mer-m8	45509671	45509692	151	-16.69
ADediting_1520234	chr1_45509918_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-153-5p	chr1	45509915	45509921	7mer-m8	45509900	45509922	144	-8.17
ADediting_1520235	chr1_45509920_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-153-5p	chr1	45509915	45509921	7mer-m8	45509900	45509922	144	-8.17
ADediting_1520236	chr1_45510005_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6778-3p	chr1	45510001	45510008	8mer-1a	45509990	45510008	151	-21.71
ADediting_1520236	chr1_45510005_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6791-3p	chr1	45510002	45510008	7mer-1a	45509989	45510008	145	-23.91
ADediting_1520236	chr1_45510005_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-6836-3p	chr1	45510002	45510008	7mer-m8	45509989	45510009	145	-19.32
ADediting_1520236	chr1_45510005_+	ENSG00000132763.15	ENST00000401061.9	MMACHC-201	hsa-miR-7113-3p	chr1	45509999	45510005	7mer-m8	45509984	45510006	140	-18.83

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_118477	chr1_45509484_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-4468	chr1	45509481	45509488	8mer-1a	45509472	45509488	146	-13.78
ADediting_118479	chr1_45509494_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-485-5p	chr1	45509492	45509498	7mer-m8	45509479	45509499	153	-19.67
ADediting_118479	chr1_45509494_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6884-5p	chr1	45509492	45509498	7mer-m8	45509477	45509499	147	-22.01
ADediting_118532	chr1_45509997_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-7152-3p	chr1	45509996	45510002	7mer-m8	45509984	45510003	140	-16.13
ADediting_118533	chr1_45509998_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-149-5p	chr1	45509996	45510002	7mer-m8	45509980	45510003	151	-21.39
ADediting_118533	chr1_45509998_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-372-5p	chr1	45509992	45509998	7mer-m8	45509977	45509999	145	-12.33
ADediting_118534	chr1_45510001_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-671-3p	chr1	45509996	45510002	7mer-m8	45509983	45510003	151	-19.43
ADediting_118534	chr1_45510001_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6763-3p	chr1	45509999	45510005	7mer-m8	45509986	45510006	140	-22.64
ADediting_118535	chr1_45510009_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-1281	chr1	45510003	45510009	7mer-m8	45509994	45510010	141	-17.27
ADediting_118541	chr1_45510334_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-125a-5p	chr1	45510330	45510336	7mer-m8	45510314	45510337	147	-18.02
ADediting_118541	chr1_45510334_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-125b-5p	chr1	45510330	45510336	7mer-m8	45510316	45510337	147	-18.02
ADediting_118541	chr1_45510334_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-210-5p	chr1	45510332	45510338	7mer-m8	45510316	45510339	142	-17.51
ADediting_118541	chr1_45510334_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-4319	chr1	45510330	45510336	7mer-m8	45510320	45510337	148	-18.89
ADediting_118541	chr1_45510334_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-4649-3p	chr1	45510328	45510334	7mer-m8	45510315	45510335	145	-17.38
ADediting_118541	chr1_45510334_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-544b	chr1	45510329	45510335	7mer-m8	45510312	45510336	149	-16.4
ADediting_118543	chr1_45510440_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-513a-5p	chr1	45510435	45510441	7mer-m8	45510425	45510442	152	-22.25
ADediting_118543	chr1_45510440_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-638	chr1	45510440	45510446	7mer-1a	45510422	45510446	157	-33.44
ADediting_118545	chr1_45510485_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-3938	chr1	45510484	45510490	7mer-m8	45510470	45510491	140	-16.05
ADediting_118545	chr1_45510485_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6747-3p	chr1	45510480	45510486	7mer-m8	45510460	45510487	143	-32.47
ADediting_118545	chr1_45510485_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6752-3p	chr1	45510481	45510488	8mer-1a	45510468	45510488	142	-20.64
ADediting_1520236	chr1_45510005_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-1913	chr1	45510004	45510011	8mer-1a	45509990	45510011	147	-21.73
ADediting_1520236	chr1_45510005_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-331-3p	chr1	45509999	45510005	7mer-m8	45509986	45510006	141	-16.58

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_118475	chr1_45509475_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-1227-3p	chr1	45509470	45509477	8mer-1a	45509458	45509477	148	-18.2
ADediting_118476	chr1_45509477_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-873-3p	chr1	45509476	45509482	7mer-m8	45509457	45509483	141	-22.88
ADediting_118477	chr1_45509484_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6832-5p	chr1	45509479	45509485	7mer-m8	45509464	45509486	140	-17.32
ADediting_118477	chr1_45509484_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6869-5p	chr1	45509482	45509488	7mer-m8	45509467	45509489	154	-23.16
ADediting_118478	chr1_45509493_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-377-5p	chr1	45509492	45509498	7mer-m8	45509478	45509499	155	-18.38
ADediting_118478	chr1_45509493_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6086	chr1	45509492	45509498	7mer-m8	45509480	45509499	150	-20.42
ADediting_118478	chr1_45509493_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6516-5p	chr1	45509488	45509494	7mer-m8	45509470	45509495	147	-13.95
ADediting_118479	chr1_45509494_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-377-5p	chr1	45509492	45509498	7mer-m8	45509478	45509499	155	-18.38
ADediting_118479	chr1_45509494_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6086	chr1	45509492	45509498	7mer-m8	45509480	45509499	150	-20.42
ADediting_118479	chr1_45509494_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6516-5p	chr1	45509488	45509494	7mer-m8	45509470	45509495	147	-13.95
ADediting_118532	chr1_45509997_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-607	chr1	45509992	45509998	7mer-m8	45509981	45509999	145	-11.64
ADediting_118533	chr1_45509998_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-607	chr1	45509992	45509998	7mer-m8	45509981	45509999	145	-11.64
ADediting_118534	chr1_45510001_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-7113-3p	chr1	45510000	45510006	7mer-m8	45509985	45510007	140	-18.83
ADediting_118535	chr1_45510009_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-5001-3p	chr1	45510005	45510011	7mer-m8	45509988	45510012	153	-20.4
ADediting_118535	chr1_45510009_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6836-3p	chr1	45510003	45510009	7mer-m8	45509990	45510010	145	-19.32
ADediting_118536	chr1_45510042_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-3944-5p	chr1	45510037	45510043	7mer-m8	45510024	45510044	149	-15.96
ADediting_118536	chr1_45510042_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-7156-3p	chr1	45510036	45510042	7mer-m8	45510015	45510043	148	-25.2
ADediting_118537	chr1_45510059_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6760-3p	chr1	45510056	45510062	7mer-m8	45510043	45510063	148	-19.47
ADediting_118537	chr1_45510059_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6773-3p	chr1	45510054	45510060	7mer-m8	45510040	45510061	142	-14.97
ADediting_118541	chr1_45510334_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-4780	chr1	45510331	45510337	7mer-m8	45510317	45510338	154	-17.59
ADediting_118541	chr1_45510334_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6851-3p	chr1	45510333	45510339	7mer-m8	45510320	45510340	142	-14.11
ADediting_118542	chr1_45510434_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-125a-3p	chr1	45510432	45510438	7mer-m8	45510418	45510439	149	-23.27
ADediting_118542	chr1_45510434_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-552-3p	chr1	45510433	45510440	8mer-1a	45510420	45510440	148	-17.31
ADediting_118543	chr1_45510440_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-10399-5p	chr1	45510436	45510442	7mer-m8	45510420	45510443	149	-15.29
ADediting_118543	chr1_45510440_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6504-3p	chr1	45510436	45510442	7mer-m8	45510424	45510443	146	-12.87
ADediting_118544	chr1_45510441_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-10399-5p	chr1	45510436	45510442	7mer-m8	45510420	45510443	149	-15.29
ADediting_118544	chr1_45510441_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-5089-5p	chr1	45510440	45510446	7mer-m8	45510427	45510447	151	-20.46
ADediting_118544	chr1_45510441_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6504-3p	chr1	45510436	45510442	7mer-m8	45510424	45510443	146	-12.87
ADediting_118545	chr1_45510485_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-1915-5p	chr1	45510481	45510488	8mer-1a	45510465	45510488	152	-22.36
ADediting_118545	chr1_45510485_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-3152-5p	chr1	45510479	45510485	7mer-m8	45510465	45510486	142	-15.92
ADediting_118545	chr1_45510485_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-502-5p	chr1	45510482	45510489	8mer-1a	45510471	45510489	150	-20.05
ADediting_1520230	chr1_45509488_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6869-5p	chr1	45509482	45509488	7mer-m8	45509467	45509489	154	-23.16
ADediting_1520236	chr1_45510005_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6778-3p	chr1	45510002	45510009	8mer-1a	45509991	45510009	151	-21.71
ADediting_1520236	chr1_45510005_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6791-3p	chr1	45510003	45510009	7mer-1a	45509990	45510009	145	-23.91
ADediting_1520236	chr1_45510005_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-6836-3p	chr1	45510003	45510009	7mer-m8	45509990	45510010	145	-19.32
ADediting_1520236	chr1_45510005_+	ENSG00000132763.15	ENST00000477188.1	MMACHC-202	hsa-miR-7113-3p	chr1	45510000	45510006	7mer-m8	45509985	45510007	140	-18.83

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_1337757

chr7_5495852_-

ENSG00000132763.15

ENST00000401061.9

MMACHC-201

hsa-miR-589-3p

chr1

45510819

45510825

7mer-m8

45510802

45510826

147

-21.01

ADediting_1337757

chr7_5495852_-

ENSG00000132763.15

ENST00000616135.1

MMACHC-203

hsa-miR-589-3p

chr1

45510819

45510825

7mer-m8

45510802

45510826

147

-21.01

ADediting_1337758

chr7_5495892_-

ENSG00000132763.15

ENST00000401061.9

MMACHC-201

hsa-miR-589-5p

chr1

45510715

45510722

8mer-1a

45510699

45510722

150

-21.66

ADediting_1337758

chr7_5495892_-

ENSG00000132763.15

ENST00000616135.1

MMACHC-203

hsa-miR-589-5p

chr1

45510715

45510722

8mer-1a

45510699

45510722

150

-21.66

ADediting_1535951

chr14_100874558_+

ENSG00000132763.15

ENST00000401061.9

MMACHC-201

hsa-miR-337-3p

chr1

45509684

45509691

8mer-1a

45509667

45509691

145

-14.42

ADediting_843620

chr2_207754818_+

ENSG00000132763.15

ENST00000401061.9

MMACHC-201

hsa-miR-4775

chr1

45511002

45511009

8mer-1a

45510988

45511009

140

-8.18

ADediting_843620

chr2_207754818_+

ENSG00000132763.15

ENST00000616135.1

MMACHC-203

hsa-miR-4775

chr1

45511002

45511009

8mer-1a

45510988

45511009

140

-8.18

ADediting_98288

chr1_32086990_+

ENSG00000132763.15

ENST00000401061.9

MMACHC-201

hsa-miR-5585-3p

chr1

45509481

45509487

7mer-m8

45509462

45509488

149

-21

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_1471003

chr9_63819626_+

ENSG00000132763.15

ENST00000401061.9

MMACHC-201

hsa-miR-4477b

chr1

45511701

45511707

7mer-m8

45511689

45511708

153

-9.74

ADediting_1471004

chr9_63819627_+

ENSG00000132763.15

ENST00000401061.9

MMACHC-201

hsa-miR-4477b

chr1

45511701

45511707

7mer-m8

45511689

45511708

153

-9.74

ADediting_1643790

chr3_121049689_+

ENSG00000132763.15

ENST00000401061.9

MMACHC-201

hsa-miR-5682

chr1

45512920

45512926

7mer-m8

45512906

45512927

142

-12.18

ADediting_496066

chr15_66496985_-

ENSG00000132763.15

ENST00000401061.9

MMACHC-201

hsa-miR-4512

chr1

45510186

45510192

7mer-m8

45510172

45510193

145

-22.12

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for MMACHC

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000401061.9	protein_coding
ENST00000616135.1	protein_coding
ENST00000477188.1	lncRNA

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_1520229	ENST00000401061.9	chr1_45508804_+	471	-1982.51	-1979.51	-2026.60
ADediting_118470	ENST00000401061.9	chr1_45509433_+	1100	-1981.11	-1979.51	-2026.60
ADediting_118471	ENST00000401061.9	chr1_45509437_+	1104	-1978.81	-1979.51	-2026.60
ADediting_118472	ENST00000401061.9	chr1_45509439_+	1106	-1978.61	-1979.51	-2026.60
ADediting_118473	ENST00000401061.9	chr1_45509445_+	1112	-1978.51	-1979.51	-2026.60
ADediting_118474	ENST00000401061.9	chr1_45509453_+	1120	-1979.11	-1979.51	-2026.60
ADediting_118475	ENST00000401061.9	chr1_45509475_+	1142	-1984.61	-1979.51	-2026.60
ADediting_118476	ENST00000401061.9	chr1_45509477_+	1144	-1978.71	-1979.51	-2026.60
ADediting_118477	ENST00000401061.9	chr1_45509484_+	1151	-1983.61	-1979.51	-2026.60
ADediting_1520230	ENST00000401061.9	chr1_45509488_+	1155	-1979.11	-1979.51	-2026.60
ADediting_118478	ENST00000401061.9	chr1_45509493_+	1160	-1979.21	-1979.51	-2026.60
ADediting_118479	ENST00000401061.9	chr1_45509494_+	1161	-1979.21	-1979.51	-2026.60
ADediting_118480	ENST00000401061.9	chr1_45509514_+	1181	-1979.11	-1979.51	-2026.60
ADediting_118481	ENST00000401061.9	chr1_45509517_+	1184	-1984.01	-1979.51	-2026.60
ADediting_118482	ENST00000401061.9	chr1_45509521_+	1188	-1981.31	-1979.51	-2026.60
ADediting_118483	ENST00000401061.9	chr1_45509530_+	1197	-1978.81	-1979.51	-2026.60
ADediting_118484	ENST00000401061.9	chr1_45509542_+	1209	-1979.21	-1979.51	-2026.60
ADediting_118485	ENST00000401061.9	chr1_45509552_+	1219	-1979.81	-1979.51	-2026.60
ADediting_1520231	ENST00000401061.9	chr1_45509570_+	1237	-1983.31	-1979.51	-2026.60
ADediting_118486	ENST00000401061.9	chr1_45509578_+	1245	-1979.61	-1979.51	-2026.60
ADediting_118487	ENST00000401061.9	chr1_45509594_+	1261	-1979.21	-1979.51	-2026.60
ADediting_118488	ENST00000401061.9	chr1_45509597_+	1264	-1979.21	-1979.51	-2026.60
ADediting_118489	ENST00000401061.9	chr1_45509599_+	1266	-1978.61	-1979.51	-2026.60
ADediting_118490	ENST00000401061.9	chr1_45509614_+	1281	-1982.91	-1979.51	-2026.60
ADediting_118491	ENST00000401061.9	chr1_45509616_+	1283	-1979.51	-1979.51	-2026.60
ADediting_118492	ENST00000401061.9	chr1_45509623_+	1290	-1978.81	-1979.51	-2026.60
ADediting_118493	ENST00000401061.9	chr1_45509635_+	1302	-1979.91	-1979.51	-2026.60
ADediting_118494	ENST00000401061.9	chr1_45509636_+	1303	-1979.51	-1979.51	-2026.60
ADediting_118495	ENST00000401061.9	chr1_45509651_+	1318	-1978.91	-1979.51	-2026.60
ADediting_118496	ENST00000401061.9	chr1_45509659_+	1326	-1983.71	-1979.51	-2026.60
ADediting_118497	ENST00000401061.9	chr1_45509672_+	1339	-1978.81	-1979.51	-2026.60
ADediting_118498	ENST00000401061.9	chr1_45509673_+	1340	-1985.91	-1979.51	-2026.60
ADediting_118499	ENST00000401061.9	chr1_45509674_+	1341	-1979.51	-1979.51	-2026.60
ADediting_118500	ENST00000401061.9	chr1_45509686_+	1353	-1979.51	-1979.51	-2026.60
ADediting_118501	ENST00000401061.9	chr1_45509688_+	1355	-1978.81	-1979.51	-2026.60
ADediting_1520232	ENST00000401061.9	chr1_45509692_+	1359	-1980.21	-1979.51	-2026.60
ADediting_118502	ENST00000401061.9	chr1_45509826_+	1493	-1979.61	-1979.51	-2026.60
ADediting_118503	ENST00000401061.9	chr1_45509827_+	1494	-1979.51	-1979.51	-2026.60
ADediting_118504	ENST00000401061.9	chr1_45509832_+	1499	-1978.81	-1979.51	-2026.60
ADediting_118505	ENST00000401061.9	chr1_45509835_+	1502	-1979.81	-1979.51	-2026.60
ADediting_118506	ENST00000401061.9	chr1_45509843_+	1510	-1978.61	-1979.51	-2026.60
ADediting_118507	ENST00000401061.9	chr1_45509853_+	1520	-1984.51	-1979.51	-2026.60
ADediting_118508	ENST00000401061.9	chr1_45509859_+	1526	-1978.91	-1979.51	-2026.60
ADediting_118509	ENST00000401061.9	chr1_45509862_+	1529	-1976.11	-1979.51	-2026.60
ADediting_118510	ENST00000401061.9	chr1_45509865_+	1532	-1978.61	-1979.51	-2026.60
ADediting_1520233	ENST00000401061.9	chr1_45509871_+	1538	-1980.41	-1979.51	-2026.60
ADediting_118511	ENST00000401061.9	chr1_45509882_+	1549	-1978.81	-1979.51	-2026.60
ADediting_118512	ENST00000401061.9	chr1_45509892_+	1559	-1979.51	-1979.51	-2026.60
ADediting_118513	ENST00000401061.9	chr1_45509894_+	1561	-1978.61	-1979.51	-2026.60
ADediting_118514	ENST00000401061.9	chr1_45509896_+	1563	-1982.31	-1979.51	-2026.60
ADediting_118515	ENST00000401061.9	chr1_45509900_+	1567	-1979.01	-1979.51	-2026.60
ADediting_118516	ENST00000401061.9	chr1_45509901_+	1568	-1979.61	-1979.51	-2026.60
ADediting_118517	ENST00000401061.9	chr1_45509902_+	1569	-1979.51	-1979.51	-2026.60
ADediting_118518	ENST00000401061.9	chr1_45509916_+	1583	-1979.61	-1979.51	-2026.60
ADediting_118519	ENST00000401061.9	chr1_45509917_+	1584	-1979.61	-1979.51	-2026.60
ADediting_1520234	ENST00000401061.9	chr1_45509918_+	1585	-1979.61	-1979.51	-2026.60
ADediting_1520235	ENST00000401061.9	chr1_45509920_+	1587	-1979.51	-1979.51	-2026.60
ADediting_118520	ENST00000401061.9	chr1_45509925_+	1592	-1979.61	-1979.51	-2026.60
ADediting_118521	ENST00000401061.9	chr1_45509926_+	1593	-1979.21	-1979.51	-2026.60
ADediting_118522	ENST00000401061.9	chr1_45509930_+	1597	-1979.21	-1979.51	-2026.60
ADediting_118523	ENST00000401061.9	chr1_45509938_+	1605	-1983.71	-1979.51	-2026.60
ADediting_118524	ENST00000401061.9	chr1_45509943_+	1610	-1983.81	-1979.51	-2026.60
ADediting_118525	ENST00000401061.9	chr1_45509948_+	1615	-1979.81	-1979.51	-2026.60
ADediting_118526	ENST00000401061.9	chr1_45509956_+	1623	-1982.11	-1979.51	-2026.60
ADediting_118527	ENST00000401061.9	chr1_45509962_+	1629	-1978.81	-1979.51	-2026.60
ADediting_118528	ENST00000401061.9	chr1_45509966_+	1633	-1979.51	-1979.51	-2026.60
ADediting_118529	ENST00000401061.9	chr1_45509970_+	1637	-1978.81	-1979.51	-2026.60
ADediting_118530	ENST00000401061.9	chr1_45509973_+	1640	-1978.61	-1979.51	-2026.60
ADediting_118531	ENST00000401061.9	chr1_45509992_+	1659	-1983.41	-1979.51	-2026.60
ADediting_118532	ENST00000401061.9	chr1_45509997_+	1664	-1979.01	-1979.51	-2026.60
ADediting_118533	ENST00000401061.9	chr1_45509998_+	1665	-1979.51	-1979.51	-2026.60
ADediting_118534	ENST00000401061.9	chr1_45510001_+	1668	-1982.11	-1979.51	-2026.60
ADediting_1520236	ENST00000401061.9	chr1_45510005_+	1672	-1978.61	-1979.51	-2026.60
ADediting_118535	ENST00000401061.9	chr1_45510009_+	1676	-1978.81	-1979.51	-2026.60
ADediting_118536	ENST00000401061.9	chr1_45510042_+	1709	-1979.11	-1979.51	-2026.60
ADediting_118537	ENST00000401061.9	chr1_45510059_+	1726	-1978.81	-1979.51	-2026.60
ADediting_118538	ENST00000401061.9	chr1_45510082_+	1749	-1979.61	-1979.51	-2026.60
ADediting_118539	ENST00000401061.9	chr1_45510083_+	1750	-1979.61	-1979.51	-2026.60
ADediting_118540	ENST00000401061.9	chr1_45510085_+	1752	-1979.61	-1979.51	-2026.60
ADediting_1601038	ENST00000401061.9	chr1_45510086_+	1753	-1979.61	-1979.51	-2026.60
ADediting_118541	ENST00000401061.9	chr1_45510334_+	2001	-1983.41	-1979.51	-2026.60
ADediting_118542	ENST00000401061.9	chr1_45510434_+	2101	-1983.60	-1979.51	-2026.60
ADediting_118543	ENST00000401061.9	chr1_45510440_+	2107	-1985.21	-1979.51	-2026.60
ADediting_118544	ENST00000401061.9	chr1_45510441_+	2108	-1980.51	-1979.51	-2026.60
ADediting_118545	ENST00000401061.9	chr1_45510485_+	2152	-1981.40	-1979.51	-2026.60
ADediting_118546	ENST00000401061.9	chr1_45510548_+	2215	-1985.10	-1979.51	-2026.60
ADediting_1520229	ENST00000616135.1	chr1_45508804_+	430	-465.10	-460.40	-471.10
ADediting_118546	ENST00000616135.1	chr1_45510548_+	993	-466.70	-460.40	-471.10

RNA A-to-I editing in lncRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_118470	ENST00000477188.1	chr1_45509433_+	1	-274.00	-274.00	-292.90
ADediting_118471	ENST00000477188.1	chr1_45509437_+	5	-273.30	-274.00	-292.90
ADediting_118472	ENST00000477188.1	chr1_45509439_+	7	-273.10	-274.00	-292.90
ADediting_118473	ENST00000477188.1	chr1_45509445_+	13	-273.00	-274.00	-292.90
ADediting_118474	ENST00000477188.1	chr1_45509453_+	21	-273.60	-274.00	-292.90
ADediting_118475	ENST00000477188.1	chr1_45509475_+	43	-279.10	-274.00	-292.90
ADediting_118476	ENST00000477188.1	chr1_45509477_+	45	-273.20	-274.00	-292.90
ADediting_118477	ENST00000477188.1	chr1_45509484_+	52	-278.10	-274.00	-292.90
ADediting_1520230	ENST00000477188.1	chr1_45509488_+	56	-273.60	-274.00	-292.90
ADediting_118478	ENST00000477188.1	chr1_45509493_+	61	-273.70	-274.00	-292.90
ADediting_118479	ENST00000477188.1	chr1_45509494_+	62	-273.70	-274.00	-292.90
ADediting_118531	ENST00000477188.1	chr1_45509992_+	94	-276.20	-274.00	-292.90
ADediting_118532	ENST00000477188.1	chr1_45509997_+	99	-275.60	-274.00	-292.90
ADediting_118533	ENST00000477188.1	chr1_45509998_+	100	-278.80	-274.00	-292.90
ADediting_118534	ENST00000477188.1	chr1_45510001_+	103	-275.70	-274.00	-292.90
ADediting_1520236	ENST00000477188.1	chr1_45510005_+	107	-273.10	-274.00	-292.90
ADediting_118535	ENST00000477188.1	chr1_45510009_+	111	-273.30	-274.00	-292.90
ADediting_118536	ENST00000477188.1	chr1_45510042_+	144	-273.60	-274.00	-292.90
ADediting_118537	ENST00000477188.1	chr1_45510059_+	161	-273.30	-274.00	-292.90
ADediting_118538	ENST00000477188.1	chr1_45510082_+	184	-274.00	-274.00	-292.90
ADediting_118539	ENST00000477188.1	chr1_45510083_+	185	-274.00	-274.00	-292.90
ADediting_118540	ENST00000477188.1	chr1_45510085_+	187	-274.00	-274.00	-292.90
ADediting_1601038	ENST00000477188.1	chr1_45510086_+	188	-274.00	-274.00	-292.90
ADediting_118541	ENST00000477188.1	chr1_45510334_+	436	-274.00	-274.00	-292.90
ADediting_118542	ENST00000477188.1	chr1_45510434_+	536	-276.00	-274.00	-292.90
ADediting_118543	ENST00000477188.1	chr1_45510440_+	542	-274.00	-274.00	-292.90
ADediting_118544	ENST00000477188.1	chr1_45510441_+	543	-274.00	-274.00	-292.90
ADediting_118545	ENST00000477188.1	chr1_45510485_+	587	-275.80	-274.00	-292.90

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Relation with ADAR for MMACHC

Correlation between ADAR gene expression and RNA editing frequency

Tissue	ADeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
CER	ADediting_118496	chr1_45509659_+	2.92937366886761e-06	0.371148845343882	3.52488022324283e-05	0.330952666328784	0.592361553557567	-0.0440639858666767
CER	ADediting_118498	chr1_45509673_+	9.69778549158761e-05	0.312862477439205	0.00368115420711743	0.235752639516071	0.142831382910273	0.120214865957669
CER	ADediting_118500	chr1_45509686_+	0.000270761606539645	0.293238960671991	3.37076949182286e-05	0.331725995399123	0.650776767855109	0.037260300961177
CER	ADediting_118533	chr1_45509998_+	1.07841596476548e-05	0.350775278712786	0.0339622209018673	0.173277340870641	0.0237949485832676	0.184518691296776
TCX	ADediting_118533	chr1_45509998_+	0.0398202848596454	0.168049971755825	0.17969260789952	-0.110137284291322	3.64257716303105e-06	0.367838077662812
CER	ADediting_118534	chr1_45510001_+	0.000107919140681579	0.310882567520525	0.00300348988068646	0.240726090218632	0.163263879660029	0.114417105546667

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	6.44534292956544e-14	0.408795986164831	3.09764976281431e-05	0.234267738117628	3.28883447143942e-39	0.653967588765438
AC	3.09510357250317e-74	0.859487976795845	2.92454070791211e-42	0.726300317351069	8.79796208290295e-23	0.568272960974998
PCC	1.1652717875649e-50	0.833849073357962	1.79593445987097e-44	0.803651867811154	8.73827975706364e-05	0.280010702522667
CER	2.87038928703916e-21	0.674774586381322	3.36449937799767e-11	0.507608102378706	0.00609982795762813	0.222952769324836
TCX	3.03750613363208e-14	0.569000166767689	0.0366204497364849	0.170818076578275	6.51870628708913e-10	0.477427389076127
FP	1.37267824212874e-19	0.610879316446305	9.27413629543385e-13	0.502129660361412	2.92277990539006e-09	0.426484038986254
PG	1.11018952133432e-43	0.805520652483666	7.62288462446614e-19	0.590223786923427	0.049751542047529	0.144087421946167
STG	7.52544918408635e-16	0.74119030930427	1.63756322688271e-06	0.495638302426181	0.000723967198600693	0.361674862888237

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Relation with AD stages for MMACHC

Correlation between AD stages and RNA editing frequency

Tissue	ADeditomID	position	P-val	Coeff.
IFG	ADediting_118519	chr1_45509917_+	0.0499504023418684	-0.39614837210355
IFG	ADediting_118526	chr1_45509956_+	0.00980586142254472	-0.506322591218387

Correlation between AD stages and this gene's expression

Tissue

P-val

Coeff.

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RelatedDrugs for MMACHC

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
MMACHC	Q9Y4U1	DB00200	Hydroxocobalamin	Methylmalonic aciduria and homocystinuria type C protein	small molecule	approved
MMACHC	Q9Y4U1	DB00115	Cyanocobalamin	Methylmalonic aciduria and homocystinuria type C protein	small molecule	approved\|nutraceutical

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RelatedDiseases for MMACHC

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
MMACHC	C1848561	Methylmalonic acidemia with homocystinuria	5	CTD_human;ORPHANET;UNIPROT
MMACHC	C0004138	Ataxias, Hereditary	1	GENOMICS_ENGLAND

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Gene summary for MMACHC

RNA A-to-I events for MMACHC

RNA editing positional annotations for MMACHC using Annovar

RNA A-to-I editing events in the alternative splicing sites for MMACHC

Differntial gene expression between RNA A-to-I edited versus non-edited samples for MMACHC

Protein coding region RNA A-to-I editings for MMACHC

The effects of the RNA editing to the miRNA binding sites for MMACHC

The effects of the RNA editing to the stability of the RNA structures for MMACHC

Relation with ADAR for MMACHC

Relation with AD stages for MMACHC

RelatedDrugs for MMACHC

RelatedDiseases for MMACHC

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene