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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for RNF19A |
 Gene summary |
| Gene information | Gene symbol | RNF19A | Gene ID | 25897 |
| Gene name | ring finger protein 19A, RBR E3 ubiquitin protein ligase | |
| Synonyms | RNF19 | |
| Cytomap | 8q22.2 | |
| Type of gene | protein-coding | |
| Description | E3 ubiquitin-protein ligase RNF19Adouble ring-finger proteinprotein p38 interacting with transcription factor Sp1ring finger protein 19ring finger protein 19A, E3 ubiquitin protein ligasering-IBR-ring domain containing protein Dorfin | |
| Modification date | 20200313 | |
| UniProtAcc | Q9NV58, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for RNF19A |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_1377860(100276631, -), ADediting_1377861(100276655, -), ADediting_1377862(100277450, -), ADediting_1377863(100277463, -), ADediting_1377864(100277480, -), ADediting_1377865(100279932, -), ADediting_1377866(100288802, -), ADediting_1377867(100288856, -), ADediting_1377868(100288895, -), ADediting_1377869(100288912, -), ADediting_1377870(100288938, -), ADediting_1377871(100288997, -), ADediting_1377872(100289013, -), ADediting_1377873(100290240, -), ADediting_1377874(100290241, -), ADediting_1377875(100290271, -), ADediting_1377876(100290352, -), ADediting_1377877(100290366, -), ADediting_1377878(100290377, -), ADediting_1377879(100290393, -), ADediting_1377880(100290677, -), ADediting_1377881(100296230, -), ADediting_1377882(100296243, -), ADediting_1377883(100296265, -), ADediting_1377884(100296269, -), ADediting_1377885(100296323, -), ADediting_1377886(100296369, -), ADediting_1377887(100296377, -), ADediting_1377888(100299076, -), ADediting_1377889(100299078, -), ADediting_1377890(100299082, -), ADediting_1377891(100300144, -), ADediting_1377892(100300154, -), ADediting_1377893(100300157, -), ADediting_1377894(100300159, -), ADediting_1377895(100300170, -), ADediting_1377896(100300394, -), ADediting_1377897(100300433, -), ADediting_1377898(100300443, -), ADediting_1377899(100300474, -), ADediting_1377900(100300509, -), ADediting_1377901(100300521, -), ADediting_1377902(100300531, -), ADediting_1377903(100300537, -), ADediting_1377904(100300570, -), ADediting_1377905(100300571, -), ADediting_1377906(100300591, -), ADediting_1377907(100300601, -), ADediting_1377908(100300617, -), ADediting_1377909(100300619, -), ADediting_1377910(100300647, -), ADediting_1377911(100303667, -), ADediting_1377912(100303679, -), ADediting_1377913(100303680, -), ADediting_1377914(100303689, -), ADediting_1377915(100303702, -), ADediting_1377916(100303706, -), ADediting_1377917(100303719, -), ADediting_1377918(100303720, -), ADediting_1377919(100303726, -), ADediting_1377920(100303732, -), ADediting_1377921(100303810, -), ADediting_1377922(100303814, -), ADediting_1377923(100303816, -), ADediting_1377924(100303837, -), ADediting_1377925(100303853, -), ADediting_1377926(100303861, -), ADediting_1377927(100303880, -), ADediting_1377928(100303895, -), ADediting_1377929(100303899, -), ADediting_1377930(100303911, -), ADediting_1377931(100304035, -), ADediting_1377932(100304048, -), ADediting_1377933(100304053, -), ADediting_1377934(100304062, -), ADediting_1377935(100304065, -), ADediting_1377936(100304068, -), ADediting_1377937(100304072, -), ADediting_1377938(100304078, -), ADediting_1377939(100304085, -), ADediting_1377940(100304095, -), ADediting_1377941(100304101, -), ADediting_1377942(100304113, -), ADediting_1377943(100304117, -), ADediting_1377944(100304194, -), ADediting_1377945(100304199, -), ADediting_1377946(100304203, -), ADediting_1377947(100304204, -), ADediting_1377948(100304212, -), ADediting_1377949(100304213, -), ADediting_1377950(100304226, -), ADediting_1377951(100304229, -), ADediting_1377952(100304247, -), ADediting_1377953(100305068, -), ADediting_1377954(100305179, -), ADediting_1589331(100300567, -), ADediting_1589332(100304089, -), ADediting_1589333(100304243, -), ADediting_1589334(100304253, -), ADediting_1589335(100305061, -), ADediting_1667632(100290167, -), ADediting_1667633(100290172, -), ADediting_1667634(100290211, -), ADediting_1667635(100290339, -), ADediting_1667636(100290369, -), ADediting_1667637(100296342, -), ADediting_1667638(100299047, -), ADediting_1667639(100299054, -), ADediting_1667640(100299077, -), ADediting_1667641(100299086, -), ADediting_1667642(100299094, -), ADediting_1667643(100299101, -), ADediting_1667644(100300138, -), ADediting_1667645(100300166, -), ADediting_1667646(100300513, -), ADediting_1667647(100300529, -), ADediting_1667648(100300541, -), ADediting_1667649(100303855, -), ADediting_1667650(100303890, -), ADediting_1667651(100304063, -), ADediting_1667652(100304155, -), ADediting_1667653(100304180, -), ADediting_1667654(100305197, -), |
Top |
RNA editing positional annotations for RNF19A using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1377860 | chr8_100276631_- | intronic |
| ADediting_1377861 | chr8_100276655_- | intronic |
| ADediting_1377862 | chr8_100277450_- | intronic |
| ADediting_1377863 | chr8_100277463_- | intronic |
| ADediting_1377864 | chr8_100277480_- | intronic |
| ADediting_1377865 | chr8_100279932_- | intronic |
| ADediting_1377866 | chr8_100288802_- | intronic |
| ADediting_1377867 | chr8_100288856_- | intronic |
| ADediting_1377868 | chr8_100288895_- | intronic |
| ADediting_1377869 | chr8_100288912_- | intronic |
| ADediting_1377870 | chr8_100288938_- | intronic |
| ADediting_1377871 | chr8_100288997_- | intronic |
| ADediting_1377872 | chr8_100289013_- | intronic |
| ADediting_1377873 | chr8_100290240_- | intronic |
| ADediting_1377874 | chr8_100290241_- | intronic |
| ADediting_1377875 | chr8_100290271_- | intronic |
| ADediting_1377876 | chr8_100290352_- | intronic |
| ADediting_1377877 | chr8_100290366_- | intronic |
| ADediting_1377878 | chr8_100290377_- | intronic |
| ADediting_1377879 | chr8_100290393_- | intronic |
| ADediting_1377880 | chr8_100290677_- | intronic |
| ADediting_1377881 | chr8_100296230_- | intronic |
| ADediting_1377882 | chr8_100296243_- | intronic |
| ADediting_1377883 | chr8_100296265_- | intronic |
| ADediting_1377884 | chr8_100296269_- | intronic |
| ADediting_1377885 | chr8_100296323_- | intronic |
| ADediting_1377886 | chr8_100296369_- | intronic |
| ADediting_1377887 | chr8_100296377_- | intronic |
| ADediting_1377888 | chr8_100299076_- | intronic |
| ADediting_1377889 | chr8_100299078_- | intronic |
| ADediting_1377890 | chr8_100299082_- | intronic |
| ADediting_1377891 | chr8_100300144_- | intronic |
| ADediting_1377892 | chr8_100300154_- | intronic |
| ADediting_1377893 | chr8_100300157_- | intronic |
| ADediting_1377894 | chr8_100300159_- | intronic |
| ADediting_1377895 | chr8_100300170_- | intronic |
| ADediting_1377896 | chr8_100300394_- | intronic |
| ADediting_1377897 | chr8_100300433_- | intronic |
| ADediting_1377898 | chr8_100300443_- | intronic |
| ADediting_1377899 | chr8_100300474_- | intronic |
| ADediting_1377900 | chr8_100300509_- | intronic |
| ADediting_1377901 | chr8_100300521_- | intronic |
| ADediting_1377902 | chr8_100300531_- | UTR5 |
| ADediting_1377903 | chr8_100300537_- | UTR5 |
| ADediting_1377904 | chr8_100300570_- | UTR5 |
| ADediting_1377905 | chr8_100300571_- | UTR5 |
| ADediting_1377906 | chr8_100300591_- | UTR5 |
| ADediting_1377907 | chr8_100300601_- | UTR5 |
| ADediting_1377908 | chr8_100300617_- | UTR5 |
| ADediting_1377909 | chr8_100300619_- | UTR5 |
| ADediting_1377910 | chr8_100300647_- | UTR5 |
| ADediting_1377911 | chr8_100303667_- | intronic |
| ADediting_1377912 | chr8_100303679_- | intronic |
| ADediting_1377913 | chr8_100303680_- | intronic |
| ADediting_1377914 | chr8_100303689_- | intronic |
| ADediting_1377915 | chr8_100303702_- | intronic |
| ADediting_1377916 | chr8_100303706_- | intronic |
| ADediting_1377917 | chr8_100303719_- | intronic |
| ADediting_1377918 | chr8_100303720_- | intronic |
| ADediting_1377919 | chr8_100303726_- | intronic |
| ADediting_1377920 | chr8_100303732_- | intronic |
| ADediting_1377921 | chr8_100303810_- | intronic |
| ADediting_1377922 | chr8_100303814_- | intronic |
| ADediting_1377923 | chr8_100303816_- | intronic |
| ADediting_1377924 | chr8_100303837_- | intronic |
| ADediting_1377925 | chr8_100303853_- | intronic |
| ADediting_1377926 | chr8_100303861_- | intronic |
| ADediting_1377927 | chr8_100303880_- | intronic |
| ADediting_1377928 | chr8_100303895_- | intronic |
| ADediting_1377929 | chr8_100303899_- | intronic |
| ADediting_1377930 | chr8_100303911_- | intronic |
| ADediting_1377931 | chr8_100304035_- | intronic |
| ADediting_1377932 | chr8_100304048_- | intronic |
| ADediting_1377933 | chr8_100304053_- | intronic |
| ADediting_1377934 | chr8_100304062_- | intronic |
| ADediting_1377935 | chr8_100304065_- | intronic |
| ADediting_1377936 | chr8_100304068_- | intronic |
| ADediting_1377937 | chr8_100304072_- | intronic |
| ADediting_1377938 | chr8_100304078_- | intronic |
| ADediting_1377939 | chr8_100304085_- | intronic |
| ADediting_1377940 | chr8_100304095_- | intronic |
| ADediting_1377941 | chr8_100304101_- | intronic |
| ADediting_1377942 | chr8_100304113_- | intronic |
| ADediting_1377943 | chr8_100304117_- | intronic |
| ADediting_1377944 | chr8_100304194_- | intronic |
| ADediting_1377945 | chr8_100304199_- | intronic |
| ADediting_1377946 | chr8_100304203_- | intronic |
| ADediting_1377947 | chr8_100304204_- | intronic |
| ADediting_1377948 | chr8_100304212_- | intronic |
| ADediting_1377949 | chr8_100304213_- | intronic |
| ADediting_1377950 | chr8_100304226_- | intronic |
| ADediting_1377951 | chr8_100304229_- | intronic |
| ADediting_1377952 | chr8_100304247_- | intronic |
| ADediting_1377953 | chr8_100305068_- | intronic |
| ADediting_1377954 | chr8_100305179_- | intronic |
| ADediting_1589331 | chr8_100300567_- | UTR5 |
| ADediting_1589332 | chr8_100304089_- | intronic |
| ADediting_1589333 | chr8_100304243_- | intronic |
| ADediting_1589334 | chr8_100304253_- | intronic |
| ADediting_1589335 | chr8_100305061_- | intronic |
| ADediting_1667632 | chr8_100290167_- | intronic |
| ADediting_1667633 | chr8_100290172_- | intronic |
| ADediting_1667634 | chr8_100290211_- | intronic |
| ADediting_1667635 | chr8_100290339_- | intronic |
| ADediting_1667636 | chr8_100290369_- | intronic |
| ADediting_1667637 | chr8_100296342_- | intronic |
| ADediting_1667638 | chr8_100299047_- | intronic |
| ADediting_1667639 | chr8_100299054_- | intronic |
| ADediting_1667640 | chr8_100299077_- | intronic |
| ADediting_1667641 | chr8_100299086_- | intronic |
| ADediting_1667642 | chr8_100299094_- | intronic |
| ADediting_1667643 | chr8_100299101_- | intronic |
| ADediting_1667644 | chr8_100300138_- | intronic |
| ADediting_1667645 | chr8_100300166_- | intronic |
| ADediting_1667646 | chr8_100300513_- | intronic |
| ADediting_1667647 | chr8_100300529_- | UTR5 |
| ADediting_1667648 | chr8_100300541_- | UTR5 |
| ADediting_1667649 | chr8_100303855_- | intronic |
| ADediting_1667650 | chr8_100303890_- | intronic |
| ADediting_1667651 | chr8_100304063_- | intronic |
| ADediting_1667652 | chr8_100304155_- | intronic |
| ADediting_1667653 | chr8_100304180_- | intronic |
| ADediting_1667654 | chr8_100305197_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1377860 | chr8_100276631_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377861 | chr8_100276655_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377862 | chr8_100277450_- | SINE | Alu | Name=AluY |
| ADediting_1377863 | chr8_100277463_- | SINE | Alu | Name=AluY |
| ADediting_1377864 | chr8_100277480_- | SINE | Alu | Name=AluY |
| ADediting_1377865 | chr8_100279932_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377866 | chr8_100288802_- | SINE | Alu | Name=AluY |
| ADediting_1377867 | chr8_100288856_- | SINE | Alu | Name=AluY |
| ADediting_1377868 | chr8_100288895_- | SINE | Alu | Name=AluY |
| ADediting_1377869 | chr8_100288912_- | SINE | Alu | Name=AluY |
| ADediting_1377870 | chr8_100288938_- | SINE | Alu | Name=AluY |
| ADediting_1377871 | chr8_100288997_- | SINE | Alu | Name=AluY |
| ADediting_1377872 | chr8_100289013_- | SINE | Alu | Name=AluY |
| ADediting_1377873 | chr8_100290240_- | SINE | Alu | Name=AluSz |
| ADediting_1377874 | chr8_100290241_- | SINE | Alu | Name=AluSz |
| ADediting_1377875 | chr8_100290271_- | SINE | Alu | Name=AluSz |
| ADediting_1377876 | chr8_100290352_- | SINE | Alu | Name=AluSz |
| ADediting_1377877 | chr8_100290366_- | SINE | Alu | Name=AluSz |
| ADediting_1377878 | chr8_100290377_- | SINE | Alu | Name=AluSz |
| ADediting_1377879 | chr8_100290393_- | SINE | Alu | Name=AluSz |
| ADediting_1377880 | chr8_100290677_- | DNA | TcMar-Tigger | Name=Tigger3c |
| ADediting_1377881 | chr8_100296230_- | SINE | Alu | Name=AluSz |
| ADediting_1377882 | chr8_100296243_- | SINE | Alu | Name=AluSz |
| ADediting_1377883 | chr8_100296265_- | SINE | Alu | Name=AluSz |
| ADediting_1377884 | chr8_100296269_- | SINE | Alu | Name=AluSz |
| ADediting_1377885 | chr8_100296323_- | SINE | Alu | Name=AluSz |
| ADediting_1377886 | chr8_100296369_- | SINE | Alu | Name=AluSz |
| ADediting_1377887 | chr8_100296377_- | SINE | Alu | Name=AluSz |
| ADediting_1377896 | chr8_100300394_- | SINE | Alu | Name=AluJr |
| ADediting_1377897 | chr8_100300433_- | SINE | Alu | Name=AluJr |
| ADediting_1377898 | chr8_100300443_- | SINE | Alu | Name=AluJr |
| ADediting_1377899 | chr8_100300474_- | SINE | Alu | Name=AluJr |
| ADediting_1377900 | chr8_100300509_- | SINE | Alu | Name=AluJr |
| ADediting_1377901 | chr8_100300521_- | SINE | Alu | Name=AluJr |
| ADediting_1377902 | chr8_100300531_- | SINE | Alu | Name=AluJr |
| ADediting_1377903 | chr8_100300537_- | SINE | Alu | Name=AluJr |
| ADediting_1377904 | chr8_100300570_- | SINE | Alu | Name=AluJr |
| ADediting_1377905 | chr8_100300571_- | SINE | Alu | Name=AluJr |
| ADediting_1377906 | chr8_100300591_- | SINE | Alu | Name=AluJr |
| ADediting_1377907 | chr8_100300601_- | SINE | Alu | Name=AluJr |
| ADediting_1377908 | chr8_100300617_- | SINE | Alu | Name=AluJr |
| ADediting_1377909 | chr8_100300619_- | SINE | Alu | Name=AluJr |
| ADediting_1377910 | chr8_100300647_- | SINE | Alu | Name=AluJr |
| ADediting_1377911 | chr8_100303667_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377912 | chr8_100303679_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377913 | chr8_100303680_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377914 | chr8_100303689_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377915 | chr8_100303702_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377916 | chr8_100303706_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377917 | chr8_100303719_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377918 | chr8_100303720_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377919 | chr8_100303726_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377920 | chr8_100303732_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377921 | chr8_100303810_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377922 | chr8_100303814_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377923 | chr8_100303816_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377924 | chr8_100303837_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377925 | chr8_100303853_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377926 | chr8_100303861_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377927 | chr8_100303880_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377928 | chr8_100303895_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377929 | chr8_100303899_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377930 | chr8_100303911_- | SINE | Alu | Name=AluSz6 |
| ADediting_1377931 | chr8_100304035_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377932 | chr8_100304048_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377933 | chr8_100304053_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377934 | chr8_100304062_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377935 | chr8_100304065_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377936 | chr8_100304068_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377937 | chr8_100304072_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377938 | chr8_100304078_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377939 | chr8_100304085_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377940 | chr8_100304095_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377941 | chr8_100304101_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377942 | chr8_100304113_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377943 | chr8_100304117_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377944 | chr8_100304194_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377945 | chr8_100304199_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377946 | chr8_100304203_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377947 | chr8_100304204_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377948 | chr8_100304212_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377949 | chr8_100304213_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377950 | chr8_100304226_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377951 | chr8_100304229_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377952 | chr8_100304247_- | SINE | Alu | Name=AluSq2 |
| ADediting_1377953 | chr8_100305068_- | SINE | Alu | Name=AluSx1 |
| ADediting_1377954 | chr8_100305179_- | SINE | Alu | Name=AluSx1 |
| ADediting_1589331 | chr8_100300567_- | SINE | Alu | Name=AluJr |
| ADediting_1589332 | chr8_100304089_- | SINE | Alu | Name=AluSq2 |
| ADediting_1589333 | chr8_100304243_- | SINE | Alu | Name=AluSq2 |
| ADediting_1589334 | chr8_100304253_- | SINE | Alu | Name=AluSq2 |
| ADediting_1589335 | chr8_100305061_- | SINE | Alu | Name=AluSx1 |
| ADediting_1667632 | chr8_100290167_- | SINE | Alu | Name=AluSz |
| ADediting_1667633 | chr8_100290172_- | SINE | Alu | Name=AluSz |
| ADediting_1667634 | chr8_100290211_- | SINE | Alu | Name=AluSz |
| ADediting_1667635 | chr8_100290339_- | SINE | Alu | Name=AluSz |
| ADediting_1667636 | chr8_100290369_- | SINE | Alu | Name=AluSz |
| ADediting_1667637 | chr8_100296342_- | SINE | Alu | Name=AluSz |
| ADediting_1667646 | chr8_100300513_- | SINE | Alu | Name=AluJr |
| ADediting_1667647 | chr8_100300529_- | SINE | Alu | Name=AluJr |
| ADediting_1667648 | chr8_100300541_- | SINE | Alu | Name=AluJr |
| ADediting_1667649 | chr8_100303855_- | SINE | Alu | Name=AluSz6 |
| ADediting_1667650 | chr8_100303890_- | SINE | Alu | Name=AluSz6 |
| ADediting_1667651 | chr8_100304063_- | SINE | Alu | Name=AluSq2 |
| ADediting_1667652 | chr8_100304155_- | SINE | Alu | Name=AluSq2 |
| ADediting_1667653 | chr8_100304180_- | SINE | Alu | Name=AluSq2 |
| ADediting_1667654 | chr8_100305197_- | SINE | Alu | Name=AluSx1 |
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RNA A-to-I editing events in the alternative splicing sites for RNF19A |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| ES | ADediting_1667647 | chr8_100300529_- | 100300522:100300530 | 5ss | 2e | CAGGTGTGC | 6.46 | CGGGTGTGC | 4.15 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RNF19A |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for RNF19A |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for RNF19A |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1377904 | chr8_100300570_- | ENSG00000034677.13 | ENST00000522182.1 | RNF19A-209 | hsa-miR-1199-5p | chr8 | 100300570 | 100300576 | 7mer-m8 | 100300569 | 100300588 | 156 | -30.6 |
| ADediting_1377904 | chr8_100300570_- | ENSG00000034677.13 | ENST00000522182.1 | RNF19A-209 | hsa-miR-4423-5p | chr8 | 100300565 | 100300571 | 7mer-m8 | 100300564 | 100300585 | 140 | -15.69 |
| ADediting_1377904 | chr8_100300570_- | ENSG00000034677.13 | ENST00000522182.1 | RNF19A-209 | hsa-miR-6751-3p | chr8 | 100300570 | 100300576 | 7mer-m8 | 100300569 | 100300589 | 141 | -20.47 |
| ADediting_1377907 | chr8_100300601_- | ENSG00000034677.13 | ENST00000519342.1 | RNF19A-204 | hsa-miR-6807-5p | chr8 | 100300596 | 100300602 | 7mer-m8 | 100300595 | 100300615 | 142 | -16.88 |
| ADediting_1377907 | chr8_100300601_- | ENSG00000034677.13 | ENST00000522182.1 | RNF19A-209 | hsa-miR-6807-5p | chr8 | 100300596 | 100300602 | 7mer-m8 | 100300595 | 100300615 | 142 | -16.88 |
| ADediting_1377908 | chr8_100300617_- | ENSG00000034677.13 | ENST00000519342.1 | RNF19A-204 | hsa-miR-20a-3p | chr8 | 100300614 | 100300620 | 7mer-m8 | 100300613 | 100300634 | 140 | -14.43 |
| ADediting_1377908 | chr8_100300617_- | ENSG00000034677.13 | ENST00000519342.1 | RNF19A-204 | hsa-miR-217-5p | chr8 | 100300613 | 100300619 | 7mer-m8 | 100300612 | 100300634 | 145 | -16.93 |
| ADediting_1377908 | chr8_100300617_- | ENSG00000034677.13 | ENST00000519342.1 | RNF19A-204 | hsa-miR-6807-3p | chr8 | 100300613 | 100300619 | 7mer-m8 | 100300612 | 100300634 | 170 | -28.49 |
| ADediting_1377908 | chr8_100300617_- | ENSG00000034677.13 | ENST00000522182.1 | RNF19A-209 | hsa-miR-20a-3p | chr8 | 100300614 | 100300620 | 7mer-m8 | 100300613 | 100300634 | 140 | -14.43 |
| ADediting_1377908 | chr8_100300617_- | ENSG00000034677.13 | ENST00000522182.1 | RNF19A-209 | hsa-miR-217-5p | chr8 | 100300613 | 100300619 | 7mer-m8 | 100300612 | 100300634 | 145 | -16.93 |
| ADediting_1377908 | chr8_100300617_- | ENSG00000034677.13 | ENST00000522182.1 | RNF19A-209 | hsa-miR-6807-3p | chr8 | 100300613 | 100300619 | 7mer-m8 | 100300612 | 100300634 | 170 | -28.49 |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1377906 | chr8_100300591_- | ENSG00000034677.13 | ENST00000519342.1 | RNF19A-204 | hsa-miR-17-3p | chr8 | 100300590 | 100300596 | 7mer-m8 | 100300589 | 100300610 | 150 | -16.23 |
| ADediting_1377906 | chr8_100300591_- | ENSG00000034677.13 | ENST00000522182.1 | RNF19A-209 | hsa-miR-17-3p | chr8 | 100300590 | 100300596 | 7mer-m8 | 100300589 | 100300610 | 150 | -16.23 |
| ADediting_1377908 | chr8_100300617_- | ENSG00000034677.13 | ENST00000519342.1 | RNF19A-204 | hsa-miR-10395-3p | chr8 | 100300615 | 100300621 | 7mer-m8 | 100300614 | 100300635 | 154 | -13.41 |
| ADediting_1377908 | chr8_100300617_- | ENSG00000034677.13 | ENST00000522182.1 | RNF19A-209 | hsa-miR-10395-3p | chr8 | 100300615 | 100300621 | 7mer-m8 | 100300614 | 100300635 | 154 | -13.41 |
| ADediting_1377909 | chr8_100300619_- | ENSG00000034677.13 | ENST00000519342.1 | RNF19A-204 | hsa-miR-10395-3p | chr8 | 100300615 | 100300621 | 7mer-m8 | 100300614 | 100300635 | 154 | -13.41 |
| ADediting_1377909 | chr8_100300619_- | ENSG00000034677.13 | ENST00000522182.1 | RNF19A-209 | hsa-miR-10395-3p | chr8 | 100300615 | 100300621 | 7mer-m8 | 100300614 | 100300635 | 154 | -13.41 |
| ADediting_1377910 | chr8_100300647_- | ENSG00000034677.13 | ENST00000519342.1 | RNF19A-204 | hsa-miR-1291 | chr8 | 100300642 | 100300648 | 7mer-m8 | 100300641 | 100303178 | 152 | -26.97 |
| ADediting_1377910 | chr8_100300647_- | ENSG00000034677.13 | ENST00000519342.1 | RNF19A-204 | hsa-miR-4421 | chr8 | 100300645 | 100300651 | 7mer-m8 | 100300644 | 100303172 | 145 | -19.3 |
| ADediting_1377910 | chr8_100300647_- | ENSG00000034677.13 | ENST00000519342.1 | RNF19A-204 | hsa-miR-5699-3p | chr8 | 100300645 | 100300651 | 7mer-m8 | 100300644 | 100303173 | 143 | -22.91 |
| ADediting_1377910 | chr8_100300647_- | ENSG00000034677.13 | ENST00000519342.1 | RNF19A-204 | hsa-miR-6775-3p | chr8 | 100300642 | 100300648 | 7mer-m8 | 100300641 | 100303169 | 150 | -24.79 |
| ADediting_1377910 | chr8_100300647_- | ENSG00000034677.13 | ENST00000522182.1 | RNF19A-209 | hsa-miR-1291 | chr8 | 100300642 | 100300648 | 7mer-m8 | 100300641 | 100303178 | 152 | -26.97 |
| ADediting_1377910 | chr8_100300647_- | ENSG00000034677.13 | ENST00000522182.1 | RNF19A-209 | hsa-miR-4421 | chr8 | 100300645 | 100300651 | 7mer-m8 | 100300644 | 100303172 | 145 | -19.3 |
| ADediting_1377910 | chr8_100300647_- | ENSG00000034677.13 | ENST00000522182.1 | RNF19A-209 | hsa-miR-5699-3p | chr8 | 100300645 | 100300651 | 7mer-m8 | 100300644 | 100303173 | 143 | -22.91 |
| ADediting_1377910 | chr8_100300647_- | ENSG00000034677.13 | ENST00000522182.1 | RNF19A-209 | hsa-miR-6775-3p | chr8 | 100300642 | 100300648 | 7mer-m8 | 100300641 | 100303169 | 150 | -24.79 |
| ADediting_1589331 | chr8_100300567_- | ENSG00000034677.13 | ENST00000522182.1 | RNF19A-209 | hsa-miR-296-3p | chr8 | 100300562 | 100300568 | 7mer-m8 | 100300561 | 100300580 | 148 | -17.91 |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000034677.13 | ENST00000341084.7 | RNF19A-201 | hsa-miR-337-3p | chr8 | 100257649 | 100257656 | 8mer-1a | 100257649 | 100257670 | 145 | -11.24 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000034677.13 | ENST00000519449.5 | RNF19A-205 | hsa-miR-337-3p | chr8 | 100257649 | 100257656 | 8mer-1a | 100257649 | 100257670 | 145 | -11.24 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000034677.13 | ENST00000341084.7 | RNF19A-201 | hsa-miR-381-3p | chr8 | 100257373 | 100257380 | 8mer-1a | 100257373 | 100257394 | 142 | -13.58 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000034677.13 | ENST00000519449.5 | RNF19A-205 | hsa-miR-381-3p | chr8 | 100257373 | 100257380 | 8mer-1a | 100257373 | 100257394 | 142 | -13.58 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000034677.13 | ENST00000341084.7 | RNF19A-201 | hsa-miR-4775 | chr8 | 100257516 | 100257522 | 7mer-1a | 100257516 | 100257537 | 141 | -9.23 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000034677.13 | ENST00000519449.5 | RNF19A-205 | hsa-miR-4775 | chr8 | 100257516 | 100257522 | 7mer-1a | 100257516 | 100257537 | 141 | -9.23 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000034677.13 | ENST00000341084.7 | RNF19A-201 | hsa-miR-5682 | chr8 | 100257281 | 100257287 | 7mer-m8 | 100257280 | 100257300 | 153 | -16.79 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000034677.13 | ENST00000519449.5 | RNF19A-205 | hsa-miR-5682 | chr8 | 100257281 | 100257287 | 7mer-m8 | 100257280 | 100257300 | 153 | -16.79 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for RNF19A |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000519449.5 | protein_coding |  |  |
| ENST00000523481.5 | protein_coding |  |  |
| ENST00000522182.1 | lncRNA |  |  |
| ENST00000519342.1 | lncRNA |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1667647 | ENST00000519449.5 | chr8_100300529_- | 223 | -1162.40 | -1161.00 | -1178.90 |
| ADediting_1377902 | ENST00000519449.5 | chr8_100300531_- | 221 | -1163.20 | -1161.00 | -1178.90 |
| ADediting_1377903 | ENST00000519449.5 | chr8_100300537_- | 215 | -1165.20 | -1161.00 | -1178.90 |
| ADediting_1667648 | ENST00000519449.5 | chr8_100300541_- | 211 | -1164.10 | -1161.00 | -1178.90 |
| ADediting_1589331 | ENST00000519449.5 | chr8_100300567_- | 185 | -1161.00 | -1161.00 | -1178.90 |
| ADediting_1377904 | ENST00000519449.5 | chr8_100300570_- | 182 | -1162.50 | -1161.00 | -1178.90 |
| ADediting_1377905 | ENST00000519449.5 | chr8_100300571_- | 181 | -1160.70 | -1161.00 | -1178.90 |
| ADediting_1377906 | ENST00000519449.5 | chr8_100300591_- | 161 | -1160.30 | -1161.00 | -1178.90 |
| ADediting_1377907 | ENST00000519449.5 | chr8_100300601_- | 151 | -1165.00 | -1161.00 | -1178.90 |
| ADediting_1377908 | ENST00000519449.5 | chr8_100300617_- | 135 | -1162.30 | -1161.00 | -1178.90 |
| ADediting_1377909 | ENST00000519449.5 | chr8_100300619_- | 133 | -1160.60 | -1161.00 | -1178.90 |
| ADediting_1377910 | ENST00000519449.5 | chr8_100300647_- | 105 | -1161.40 | -1161.00 | -1178.90 |
| ADediting_1667647 | ENST00000523481.5 | chr8_100300529_- | 409 | -156.40 | -154.40 | -177.10 |
| ADediting_1377902 | ENST00000523481.5 | chr8_100300531_- | 407 | -157.20 | -154.40 | -177.10 |
| ADediting_1377903 | ENST00000523481.5 | chr8_100300537_- | 401 | -158.10 | -154.40 | -177.10 |
| ADediting_1667648 | ENST00000523481.5 | chr8_100300541_- | 397 | -159.60 | -154.40 | -177.10 |
| ADediting_1589331 | ENST00000523481.5 | chr8_100300567_- | 371 | -155.30 | -154.40 | -177.10 |
| ADediting_1377904 | ENST00000523481.5 | chr8_100300570_- | 368 | -158.00 | -154.40 | -177.10 |
| ADediting_1377905 | ENST00000523481.5 | chr8_100300571_- | 367 | -155.60 | -154.40 | -177.10 |
| ADediting_1377906 | ENST00000523481.5 | chr8_100300591_- | 347 | -154.10 | -154.40 | -177.10 |
| ADediting_1377907 | ENST00000523481.5 | chr8_100300601_- | 337 | -158.40 | -154.40 | -177.10 |
| ADediting_1377908 | ENST00000523481.5 | chr8_100300617_- | 321 | -156.20 | -154.40 | -177.10 |
| ADediting_1377909 | ENST00000523481.5 | chr8_100300619_- | 319 | -155.30 | -154.40 | -177.10 |
| ADediting_1377910 | ENST00000523481.5 | chr8_100300647_- | 291 | -154.80 | -154.40 | -177.10 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1589331 | ENST00000522182.1 | chr8_100300567_- | 520 | -182.60 | -183.30 | -191.00 |
| ADediting_1377904 | ENST00000522182.1 | chr8_100300570_- | 517 | -186.90 | -183.30 | -191.00 |
| ADediting_1377905 | ENST00000522182.1 | chr8_100300571_- | 516 | -184.10 | -183.30 | -191.00 |
| ADediting_1377906 | ENST00000522182.1 | chr8_100300591_- | 496 | -184.20 | -183.30 | -191.00 |
| ADediting_1377907 | ENST00000522182.1 | chr8_100300601_- | 486 | -185.30 | -183.30 | -191.00 |
| ADediting_1377908 | ENST00000522182.1 | chr8_100300617_- | 470 | -182.30 | -183.30 | -191.00 |
| ADediting_1377909 | ENST00000522182.1 | chr8_100300619_- | 468 | -182.90 | -183.30 | -191.00 |
| ADediting_1377910 | ENST00000522182.1 | chr8_100300647_- | 440 | -183.70 | -183.30 | -191.00 |
| ADediting_1377906 | ENST00000519342.1 | chr8_100300591_- | 549 | -240.70 | -240.60 | -247.20 |
| ADediting_1377907 | ENST00000519342.1 | chr8_100300601_- | 539 | -241.90 | -240.60 | -247.20 |
| ADediting_1377908 | ENST00000519342.1 | chr8_100300617_- | 523 | -239.70 | -240.60 | -247.20 |
| ADediting_1377909 | ENST00000519342.1 | chr8_100300619_- | 521 | -240.50 | -240.60 | -247.20 |
| ADediting_1377910 | ENST00000519342.1 | chr8_100300647_- | 493 | -241.00 | -240.60 | -247.20 |
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Relation with ADAR for RNF19A |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| TCX | ADediting_1377903 | chr8_100300537_- | 0.0389537407982266 | 0.168780566211502 | 0.727030464062041 | -0.0287366380676255 | 0.000134640072105138 | 0.306740375577045 |
| TCX | ADediting_1377908 | chr8_100300617_- | 0.0351795482531937 | 0.172131663548969 | 0.583064834427487 | -0.0451736054631543 | 3.06181919004167e-07 | 0.403479484995442 |
| TCX | ADediting_1377909 | chr8_100300619_- | 0.073657665483904 | 0.146486053631622 | 0.290599085754831 | -0.0868514189436292 | 2.49038637731603e-07 | 0.406272250201263 |
| TCX | ADediting_1377916 | chr8_100303706_- | 0.043437073192825 | 0.165137660925486 | 0.751783830455095 | -0.0260382589948161 | 1.0226302984704e-09 | 0.472573953885405 |
| TCX | ADediting_1377917 | chr8_100303719_- | 0.0424234079182632 | 0.165932744313752 | 0.608746818241667 | 0.0421273008914094 | 6.35054530560946e-07 | 0.393407180788936 |
| TCX | ADediting_1377919 | chr8_100303726_- | 0.036618792527752 | 0.170819562114745 | 0.997193350208275 | -0.000289635501048208 | 1.65197922321023e-08 | 0.440777633934206 |
| TCX | ADediting_1377952 | chr8_100304247_- | 0.0337412705058905 | 0.173489000430682 | 0.321174719818858 | -0.0815474622767818 | 5.86724302626088e-10 | 0.478551413372011 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 7.72813060230547e-57 | 0.748269040232864 | 1.66425160259966e-33 | 0.613979083543388 | 0.00226596184142273 | 0.172788464948108 |
| AC | 2.56935830734572e-40 | 0.714290837105707 | 1.59861478249549e-18 | 0.517443081693992 | 5.83772455863737e-36 | 0.684923322694418 |
| PCC | 5.17922980964342e-38 | 0.765308417718202 | 1.04955353057966e-29 | 0.702285244561619 | 2.93183144096544e-10 | 0.435873133145546 |
| CER | 3.08022821521696e-51 | 0.885925784033557 | 7.88966420177899e-30 | 0.762902352289305 | 1.15997595426163e-06 | 0.384830738936989 |
| TCX | 2.40014939602818e-16 | 0.605040945995701 | 0.0271211834502436 | 0.1804526243835 | 1.86508594352817e-15 | 0.590316606838877 |
| FP | 2.49660892461084e-17 | 0.579122971628532 | 1.51501020068039e-16 | 0.567256302964532 | 0.000699229690970719 | 0.251751135896445 |
| IFG | 3.14737614410109e-06 | 0.786436233873503 | 0.00336388528734812 | 0.563357436337498 | 0.00602866952011132 | 0.533468453605838 |
| PG | 2.40169240110358e-34 | 0.746197073668035 | 2.78655721966516e-21 | 0.621759902140889 | 0.0798561361603324 | 0.128760647256373 |
| STG | 6.70664625564686e-13 | 0.684939298794786 | 1.36823380431794e-05 | 0.455056485659407 | 0.00221836731568272 | 0.3293681225489 |
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Relation with AD stages for RNF19A |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| TCX | ADediting_1377903 | chr8_100300537_- | 0.0013012371884317 | 0.308345902720091 |
| TCX | ADediting_1377908 | chr8_100300617_- | 0.000115306582181703 | 0.365789301997412 |
| TCX | ADediting_1377909 | chr8_100300619_- | 6.84054647614706e-05 | 0.376852426064844 |
| TCX | ADediting_1377916 | chr8_100303706_- | 0.000394207194078343 | 0.338034413201054 |
| TCX | ADediting_1377917 | chr8_100303719_- | 0.000482562744287317 | 0.333212281092405 |
| TCX | ADediting_1377919 | chr8_100303726_- | 0.000168199697028352 | 0.357532457947344 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 2.20754747397637e-07 | 0.473939878670342 |
| TCX | 1.80225625075748e-11 | 0.594670673435004 |
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RelatedDrugs for RNF19A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNF19A |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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