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Center for Computational Systems Medicine
Soverview

Gene summary

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RNA A-to-I events

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Differntial gene expression between RNA A-to-I edited versus non-edited samples

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Protein coding region RNA A-to-I editings

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The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

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Relation with ADAR

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Relation with AD stages

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Related drugs with this gene

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Related diseases with this gene


Gene summary for RPL36

check button Gene summary
Gene informationGene symbol

RPL36

Gene ID

25873

Gene nameribosomal protein L36
SynonymsL36
Cytomap

19p13.3

Type of geneprotein-coding
Description60S ribosomal protein L36large ribosomal subunit protein eL36
Modification date20200313
UniProtAcc

Q9Y3U8,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
RPL36

GO:0002181

cytoplasmic translation

25957688


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RNA A-to-I events for RPL36

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_784263(5682841, +), ADediting_784264(5682869, +), ADediting_784265(5682919, +), ADediting_784266(5682958, +), ADediting_784267(5682960, +), ADediting_784268(5682961, +), ADediting_784269(5682962, +), ADediting_784270(5682964, +), ADediting_784271(5682973, +), ADediting_784272(5683001, +), ADediting_784273(5683029, +), ADediting_784274(5683031, +), ADediting_784275(5683042, +), ADediting_784276(5683056, +), ADediting_784277(5683069, +), ADediting_784278(5683072, +), ADediting_784279(5683089, +), ADediting_784280(5683111, +), ADediting_784281(5683117, +), ADediting_784282(5683124, +), ADediting_784283(5683136, +), ADediting_784284(5683152, +), ADediting_784285(5683197, +), ADediting_784286(5683198, +), ADediting_784288(5683618, +), ADediting_784289(5683630, +), ADediting_784290(5683637, +), ADediting_784291(5683672, +), ADediting_784292(5683677, +), ADediting_784293(5683682, +), ADediting_784294(5683690, +), ADediting_784295(5683691, +), ADediting_784296(5683692, +), ADediting_784297(5683710, +), ADediting_784298(5683721, +), ADediting_784299(5683729, +), ADediting_784300(5683730, +), ADediting_784301(5683736, +), ADediting_784302(5683745, +), ADediting_784303(5683773, +), ADediting_784304(5683796, +), ADediting_784305(5683800, +), ADediting_784306(5683801, +), ADediting_784307(5683814, +), ADediting_784308(5683819, +), ADediting_784309(5683820, +), ADediting_784310(5683828, +), ADediting_784311(5683835, +), ADediting_784312(5683843, +), ADediting_784313(5683876, +), ADediting_784314(5684033, +), ADediting_784315(5684053, +), ADediting_784316(5684056, +), ADediting_784317(5684069, +), ADediting_784318(5684076, +), ADediting_784319(5684114, +), ADediting_784320(5684145, +), ADediting_784321(5684155, +), ADediting_784322(5684196, +), ADediting_784323(5684197, +), ADediting_784324(5684199, +), ADediting_784325(5684201, +), ADediting_784326(5684213, +), ADediting_784327(5684216, +), ADediting_784328(5684225, +), ADediting_784329(5684238, +), ADediting_784330(5684250, +), ADediting_784331(5684251, +), ADediting_784332(5684255, +), ADediting_784333(5684268, +), ADediting_784334(5684278, +), ADediting_784335(5684296, +), ADediting_784336(5685322, +), ADediting_784337(5685326, +), ADediting_784338(5685659, +), ADediting_784339(5685819, +), ADediting_784340(5688654, +), ADediting_784341(5688674, +), ADediting_784342(5688682, +), ADediting_784343(5689218, +), ADediting_1559225(5684277, +), ADediting_1559226(5685415, +), ADediting_1559227(5685783, +), ADediting_1559228(5688668, +),

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RNA editing positional annotations for RPL36 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_784263chr19_5682841_+intronic
ADediting_784264chr19_5682869_+intronic
ADediting_784265chr19_5682919_+intronic
ADediting_784266chr19_5682958_+intronic
ADediting_784267chr19_5682960_+intronic
ADediting_784268chr19_5682961_+intronic
ADediting_784269chr19_5682962_+intronic
ADediting_784270chr19_5682964_+intronic
ADediting_784271chr19_5682973_+intronic
ADediting_784272chr19_5683001_+intronic
ADediting_784273chr19_5683029_+intronic
ADediting_784274chr19_5683031_+intronic
ADediting_784275chr19_5683042_+intronic
ADediting_784276chr19_5683056_+intronic
ADediting_784277chr19_5683069_+intronic
ADediting_784278chr19_5683072_+intronic
ADediting_784279chr19_5683089_+intronic
ADediting_784280chr19_5683111_+intronic
ADediting_784281chr19_5683117_+intronic
ADediting_784282chr19_5683124_+intronic
ADediting_784283chr19_5683136_+intronic
ADediting_784284chr19_5683152_+intronic
ADediting_784285chr19_5683197_+intronic
ADediting_784286chr19_5683198_+intronic
ADediting_784288chr19_5683618_+intronic
ADediting_784289chr19_5683630_+intronic
ADediting_784290chr19_5683637_+intronic
ADediting_784291chr19_5683672_+intronic
ADediting_784292chr19_5683677_+intronic
ADediting_784293chr19_5683682_+intronic
ADediting_784294chr19_5683690_+intronic
ADediting_784295chr19_5683691_+intronic
ADediting_784296chr19_5683692_+intronic
ADediting_784297chr19_5683710_+intronic
ADediting_784298chr19_5683721_+intronic
ADediting_784299chr19_5683729_+intronic
ADediting_784300chr19_5683730_+intronic
ADediting_784301chr19_5683736_+intronic
ADediting_784302chr19_5683745_+intronic
ADediting_784303chr19_5683773_+intronic
ADediting_784304chr19_5683796_+intronic
ADediting_784305chr19_5683800_+intronic
ADediting_784306chr19_5683801_+intronic
ADediting_784307chr19_5683814_+intronic
ADediting_784308chr19_5683819_+intronic
ADediting_784309chr19_5683820_+intronic
ADediting_784310chr19_5683828_+intronic
ADediting_784311chr19_5683835_+intronic
ADediting_784312chr19_5683843_+intronic
ADediting_784313chr19_5683876_+intronic
ADediting_784314chr19_5684033_+exonic
ADediting_784315chr19_5684053_+exonic
ADediting_784316chr19_5684056_+exonic
ADediting_784317chr19_5684069_+exonic
ADediting_784318chr19_5684076_+exonic
ADediting_784319chr19_5684114_+exonic
ADediting_784320chr19_5684145_+intronic
ADediting_784321chr19_5684155_+intronic
ADediting_784322chr19_5684196_+intronic
ADediting_784323chr19_5684197_+intronic
ADediting_784324chr19_5684199_+splicing
ADediting_784325chr19_5684201_+UTR5
ADediting_784326chr19_5684213_+UTR5
ADediting_784327chr19_5684216_+UTR5
ADediting_784328chr19_5684225_+UTR5
ADediting_784329chr19_5684238_+UTR5
ADediting_784330chr19_5684250_+UTR5
ADediting_784331chr19_5684251_+UTR5
ADediting_784332chr19_5684255_+UTR5
ADediting_784333chr19_5684268_+UTR5
ADediting_784334chr19_5684278_+UTR5
ADediting_784335chr19_5684296_+UTR5
ADediting_784336chr19_5685322_+exonic
ADediting_784337chr19_5685326_+exonic
ADediting_784338chr19_5685659_+intronic
ADediting_784339chr19_5685819_+intronic
ADediting_784340chr19_5688654_+intronic
ADediting_784341chr19_5688674_+intronic
ADediting_784342chr19_5688682_+intronic
ADediting_784343chr19_5689218_+intronic
ADediting_1559225chr19_5684277_+UTR5
ADediting_1559226chr19_5685415_+UTR3
ADediting_1559227chr19_5685783_+intronic
ADediting_1559228chr19_5688668_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_784263chr19_5682841_+SINEAluName=AluSx
ADediting_784264chr19_5682869_+SINEAluName=AluSx
ADediting_784265chr19_5682919_+SINEAluName=AluSx
ADediting_784266chr19_5682958_+SINEAluName=AluJo
ADediting_784267chr19_5682960_+SINEAluName=AluJo
ADediting_784268chr19_5682961_+SINEAluName=AluJo
ADediting_784269chr19_5682962_+SINEAluName=AluJo
ADediting_784270chr19_5682964_+SINEAluName=AluJo
ADediting_784271chr19_5682973_+SINEAluName=AluJo
ADediting_784272chr19_5683001_+SINEAluName=AluJo
ADediting_784273chr19_5683029_+SINEAluName=AluSx
ADediting_784274chr19_5683031_+SINEAluName=AluSx
ADediting_784275chr19_5683042_+SINEAluName=AluSx
ADediting_784276chr19_5683056_+SINEAluName=AluSx
ADediting_784277chr19_5683069_+SINEAluName=AluSx
ADediting_784278chr19_5683072_+SINEAluName=AluSx
ADediting_784279chr19_5683089_+SINEAluName=AluSx
ADediting_784280chr19_5683111_+SINEAluName=AluSx
ADediting_784281chr19_5683117_+SINEAluName=AluSx
ADediting_784282chr19_5683124_+SINEAluName=AluSx
ADediting_784283chr19_5683136_+SINEAluName=AluSx
ADediting_784284chr19_5683152_+SINEAluName=AluSx
ADediting_784285chr19_5683197_+SINEAluName=AluSp
ADediting_784286chr19_5683198_+SINEAluName=AluSp
ADediting_784288chr19_5683618_+SINEAluName=AluJo
ADediting_784289chr19_5683630_+SINEAluName=AluJo
ADediting_784290chr19_5683637_+SINEAluName=AluJo
ADediting_784291chr19_5683672_+SINEAluName=AluJo
ADediting_784292chr19_5683677_+SINEAluName=AluJo
ADediting_784293chr19_5683682_+SINEAluName=AluJo
ADediting_784294chr19_5683690_+SINEAluName=AluJo
ADediting_784295chr19_5683691_+SINEAluName=AluJo
ADediting_784296chr19_5683692_+SINEAluName=AluJo
ADediting_784297chr19_5683710_+SINEAluName=AluJo
ADediting_784298chr19_5683721_+SINEAluName=AluJo
ADediting_784299chr19_5683729_+SINEAluName=AluJo
ADediting_784300chr19_5683730_+SINEAluName=AluJo
ADediting_784301chr19_5683736_+SINEAluName=AluJo
ADediting_784302chr19_5683745_+SINEAluName=AluJo
ADediting_784303chr19_5683773_+SINEAluName=AluJo
ADediting_784304chr19_5683796_+SINEAluName=AluJo
ADediting_784305chr19_5683800_+SINEAluName=AluJo
ADediting_784306chr19_5683801_+SINEAluName=AluJo
ADediting_784307chr19_5683814_+SINEAluName=AluJo
ADediting_784308chr19_5683819_+SINEAluName=AluJo
ADediting_784309chr19_5683820_+SINEAluName=AluJo
ADediting_784310chr19_5683828_+SINEAluName=AluJo
ADediting_784311chr19_5683835_+SINEAluName=AluJo
ADediting_784312chr19_5683843_+SINEAluName=AluJo
ADediting_784313chr19_5683876_+SINEAluName=AluJo
ADediting_784314chr19_5684033_+SINEAluName=AluSq2
ADediting_784315chr19_5684053_+SINEAluName=AluSq2
ADediting_784316chr19_5684056_+SINEAluName=AluSq2
ADediting_784317chr19_5684069_+SINEAluName=AluSq2
ADediting_784318chr19_5684076_+SINEAluName=AluSq2
ADediting_784319chr19_5684114_+SINEAluName=AluSq2
ADediting_784320chr19_5684145_+SINEAluName=AluSq2
ADediting_784321chr19_5684155_+SINEAluName=AluSq2
ADediting_784322chr19_5684196_+SINEAluName=AluSq2
ADediting_784323chr19_5684197_+SINEAluName=AluSq2
ADediting_784324chr19_5684199_+SINEAluName=AluSq2
ADediting_784325chr19_5684201_+SINEAluName=AluSq2
ADediting_784326chr19_5684213_+SINEAluName=AluSq2
ADediting_784327chr19_5684216_+SINEAluName=AluSq2
ADediting_784328chr19_5684225_+SINEAluName=AluSq2
ADediting_784329chr19_5684238_+SINEAluName=AluSq2
ADediting_784330chr19_5684250_+SINEAluName=AluSq2
ADediting_784331chr19_5684251_+SINEAluName=AluSq2
ADediting_784332chr19_5684255_+SINEAluName=AluSq2
ADediting_784333chr19_5684268_+SINEAluName=AluSq2
ADediting_784334chr19_5684278_+SINEAluName=AluSq2
ADediting_784335chr19_5684296_+SINEAluName=AluSq2
ADediting_784336chr19_5685322_+SINEAluName=AluSx
ADediting_784337chr19_5685326_+SINEAluName=AluSx
ADediting_784338chr19_5685659_+SINEAluName=AluSx1
ADediting_784339chr19_5685819_+SINEAluName=AluSx
ADediting_784340chr19_5688654_+SINEAluName=AluJb
ADediting_784341chr19_5688674_+SINEAluName=AluJb
ADediting_784342chr19_5688682_+SINEAluName=AluJb
ADediting_784343chr19_5689218_+SINEAluName=AluJb
ADediting_1559225chr19_5684277_+SINEAluName=AluSq2
ADediting_1559226chr19_5685415_+SINEAluName=AluSx
ADediting_1559227chr19_5685783_+SINEAluName=AluSx
ADediting_1559228chr19_5688668_+SINEAluName=AluJb

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RNA A-to-I editing events in the alternative splicing sites for RPL36

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RPL36

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for RPL36

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for RPL36


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for RPL36

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for RPL36

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CERADediting_784340chr19_5688654_+0.03177325367666270.1754279403164752.76410644251974e-060.3720250260947570.1204264419950010.127349275461201

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC1.04626999897483e-060.2731329925525477.88975031147418e-150.4221738875543030.01013385383472690.145843476535086
AC2.87754423129883e-450.7436988340661218.92977033904402e-280.6184505777086156.31368401063917e-240.580564385568917
PCC1.53744986122953e-070.3686903783248657.50224394443772e-080.3771935169117430.01474271584619640.17622726684275
FP2.09905756491846e-090.4299870807387894.51429720532666e-130.5080678185727490.57390136797046-0.0424272229852356
IFG0.001144792200654180.6121580108447390.005430084876001990.5390286442797750.775627937730202-0.0600259494038175
STG1.80533563314819e-060.4938831958062581.56121008741788e-050.4523550172795290.198306770246491-0.141770869471223

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Relation with AD stages for RPL36

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
PG1.61745985496171e-05-0.310421486910973

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RelatedDrugs for RPL36

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPL36

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
RPL36C0376545Hematologic Neoplasms1GENOMICS_ENGLAND