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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for GABRA3 |
 Gene summary |
| Gene information | Gene symbol | GABRA3 | Gene ID | 2556 |
| Gene name | gamma-aminobutyric acid type A receptor subunit alpha3 | |
| Synonyms | - | |
| Cytomap | Xq28 | |
| Type of gene | protein-coding | |
| Description | gamma-aminobutyric acid receptor subunit alpha-3GABA(A) receptor subunit alpha-3GABA(A) receptor, alpha 3gamma-aminobutyric acid (GABA) A receptor, alpha 3gamma-aminobutyric acid type A receptor alpha3 subunitgamma-animobutyric acid (GABA) A receptor | |
| Modification date | 20200313 | |
| UniProtAcc | P34903, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for GABRA3 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1493643(152189847, -), |
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RNA editing positional annotations for GABRA3 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_1493643 | chrX_152189847_- | nonsynonymous SNV | ENST00000370314.9 | c.A1026G | p.I342M | 0.109 | 0.023 | -2.23 |
| ADediting_1493643 | chrX_152189847_- | nonsynonymous SNV | ENST00000535043.1 | c.A1026G | p.I342M | 0.109 | 0.023 | -2.23 |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1493643 | chrX_152189847_- | exonic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
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RNA A-to-I editing events in the alternative splicing sites for GABRA3 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GABRA3 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for GABRA3 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for GABRA3 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_843620 | chr2_207754818_+ | ENSG00000011677.13 | ENST00000370314.9 | GABRA3-201 | hsa-miR-4775 | chrX | 152168052 | 152168058 | 7mer-m8 | 152168051 | 152168073 | 151 | -4.21 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for GABRA3 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000497894.1 | lncRNA |  |  |
| ENST00000370314.9 | protein_coding |  |  |
| ENST00000535043.1 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1493643 | ENST00000370314.9 | chrX_152189847_- | 1222 | -1091.30 | -1084.70 | -1091.30 |
| ADediting_1493643 | ENST00000535043.1 | chrX_152189847_- | 1244 | -494.80 | -488.20 | -494.80 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1493643 | ENST00000497894.1 | chrX_152189847_- | 97 | -122.10 | -115.50 | -122.10 |
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Relation with ADAR for GABRA3 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_1493643 | chrX_152189847_- | 6.81403544940856e-18 | 0.46321312873711 | 3.92102350195364e-15 | 0.426498667039094 | 0.0259124503687434 | -0.126517022006626 |
| TCX | ADediting_1493643 | chrX_152189847_- | 1.0238682588726e-18 | 0.640857452599694 | 2.27486205668187e-16 | 0.60541599333653 | 0.0299765630676038 | -0.17728923404862 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 6.17721164842653e-92 | 0.859864807769415 | 1.190103562239e-102 | 0.881994565452528 | 0.334756009926528 | -0.0549649929685812 |
| AC | 2.34208249238022e-40 | 0.714545799749678 | 1.92776717372342e-33 | 0.66619950636315 | 0.00065856868304976 | 0.214002794190321 |
| PCC | 6.89496878979518e-55 | 0.851510602999183 | 1.20582493699404e-48 | 0.824626809584795 | 0.46356133541304 | 0.0533500929972994 |
| CER | 4.01113359212635e-12 | 0.527577795823584 | 1.33126126373178e-05 | 0.3473468074348 | 0.149547191048492 | 0.11824394283898 |
| TCX | 3.86809120971704e-22 | 0.685395122240039 | 1.5088736617359e-26 | 0.733027211334577 | 7.30357554001362e-05 | -0.318047564907751 |
| FP | 4.75738520225443e-24 | 0.664604648213531 | 1.264079026698e-20 | 0.62432932853343 | 0.306367553522085 | -0.0770966168677109 |
| IFG | 0.000171726973452712 | 0.682334010655283 | 0.000231508454688454 | 0.672394478493833 | 0.291948730089365 | -0.219422590093871 |
| PG | 6.75147329302496e-34 | 0.742848847619547 | 6.11951861150561e-23 | 0.641350861141345 | 0.0263855447497215 | -0.16282377716403 |
| STG | 7.52758694061769e-16 | 0.741188223350482 | 4.39143638110785e-10 | 0.616197349268529 | 0.132345009571532 | -0.165545353480673 |
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Relation with AD stages for GABRA3 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| PG | ADediting_1493643 | chrX_152189847_- | 1.57305352709086e-05 | -0.310842084370044 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for GABRA3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| GABRA3 | P34903 | DB00395 | Carisoprodol | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved |
| GABRA3 | P34903 | DB00425 | Zolpidem | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved |
| GABRA3 | P34903 | DB00842 | Oxazepam | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved |
| GABRA3 | P34903 | DB00849 | Methylphenobarbital | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved |
| GABRA3 | P34903 | DB00898 | Ethanol | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved |
| GABRA3 | P34903 | DB01198 | Zopiclone | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved |
| GABRA3 | P34903 | DB01595 | Nitrazepam | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved |
| GABRA3 | P34903 | DB13872 | Lormetazepam | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved |
| GABRA3 | P34903 | DB00241 | Butalbital | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|illicit |
| GABRA3 | P34903 | DB00306 | Talbutal | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|illicit |
| GABRA3 | P34903 | DB00371 | Meprobamate | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|illicit |
| GABRA3 | P34903 | DB00683 | Midazolam | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|illicit |
| GABRA3 | P34903 | DB01215 | Estazolam | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|illicit |
| GABRA3 | P34903 | DB01351 | Amobarbital | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|illicit |
| GABRA3 | P34903 | DB01353 | Butobarbital | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|illicit |
| GABRA3 | P34903 | DB01544 | Flunitrazepam | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|illicit |
| GABRA3 | P34903 | DB01559 | Clotiazepam | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|illicit |
| GABRA3 | P34903 | DB01588 | Prazepam | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|illicit |
| GABRA3 | P34903 | DB01589 | Quazepam | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|illicit |
| GABRA3 | P34903 | DB00690 | Flurazepam | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|illicit|investigational |
| GABRA3 | P34903 | DB01558 | Bromazepam | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|illicit|investigational |
| GABRA3 | P34903 | DB00829 | Diazepam | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|illicit|investigational|vet_approved |
| GABRA3 | P34903 | DB00801 | Halazepam | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|illicit|withdrawn |
| GABRA3 | P34903 | DB00231 | Temazepam | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|investigational |
| GABRA3 | P34903 | DB00402 | Eszopiclone | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|investigational |
| GABRA3 | P34903 | DB00897 | Triazolam | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|investigational |
| GABRA3 | P34903 | DB00312 | Pentobarbital | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|investigational|vet_approved |
| GABRA3 | P34903 | DB00418 | Secobarbital | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|vet_approved |
| GABRA3 | P34903 | DB00599 | Thiopental | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|vet_approved |
| GABRA3 | P34903 | DB00794 | Primidone | Gamma-aminobutyric acid receptor subunit alpha-3 | small molecule | approved|vet_approved |
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RelatedDiseases for GABRA3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| GABRA3 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| GABRA3 | C0004352 | Autistic Disorder | 1 | CTD_human |
| GABRA3 | C0011570 | Mental Depression | 1 | PSYGENET |
| GABRA3 | C0011581 | Depressive disorder | 1 | PSYGENET |
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