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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for FYN |
 Gene summary |
| Gene information | Gene symbol | FYN | Gene ID | 2534 |
| Gene name | FYN proto-oncogene, Src family tyrosine kinase | |
| Synonyms | SLK|SYN|p59-FYN | |
| Cytomap | 6q21 | |
| Type of gene | protein-coding | |
| Description | tyrosine-protein kinase FynFYN oncogene related to SRC, FGR, YESOKT3-induced calcium influx regulatorc-syn protooncogeneproto-oncogene Synproto-oncogene c-Fynsrc-like kinasesrc/yes-related noveltyrosine kinase p59fyn(T) | |
| Modification date | 20200327 | |
| UniProtAcc | P06241, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| FYN | GO:0050852 | T cell receptor signaling pathway | 7722293 |
Top |
RNA A-to-I events for FYN |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_1226543(111665664, -), ADediting_1226544(111665718, -), ADediting_1226545(111665719, -), ADediting_1226546(111665746, -), ADediting_1226547(111665750, -), ADediting_1226548(111665760, -), ADediting_1226549(111665766, -), ADediting_1226550(111665776, -), ADediting_1226551(111665786, -), ADediting_1226552(111665798, -), ADediting_1226553(111665816, -), ADediting_1226554(111665822, -), ADediting_1226555(111665826, -), ADediting_1226556(111665842, -), ADediting_1226557(111665846, -), ADediting_1226558(111665887, -), ADediting_1226559(111665895, -), ADediting_1226560(111665896, -), ADediting_1226561(111666078, -), ADediting_1226562(111666098, -), ADediting_1226563(111666099, -), ADediting_1226564(111666126, -), ADediting_1226565(111666130, -), ADediting_1226566(111666151, -), ADediting_1226567(111666207, -), ADediting_1226568(111666459, -), ADediting_1226569(111666598, -), ADediting_1226570(111666615, -), ADediting_1226571(111666621, -), ADediting_1226572(111666653, -), ADediting_1226573(111666684, -), ADediting_1226574(111666705, -), ADediting_1226575(111666709, -), ADediting_1226576(111666711, -), ADediting_1226577(111666721, -), ADediting_1226578(111666723, -), ADediting_1226579(111666733, -), ADediting_1226580(111666747, -), ADediting_1226581(111666750, -), ADediting_1226582(111666765, -), ADediting_1226583(111666771, -), ADediting_1226584(111666773, -), ADediting_1226585(111666776, -), ADediting_1226586(111666781, -), ADediting_1226587(111666807, -), ADediting_1226588(111666936, -), ADediting_1226589(111667269, -), ADediting_1226590(111667315, -), ADediting_1226591(111667356, -), ADediting_1226592(111667374, -), ADediting_1226593(111667380, -), ADediting_1226594(111667382, -), ADediting_1226595(111667386, -), ADediting_1226596(111667453, -), ADediting_1226597(111667457, -), ADediting_1226598(111667473, -), ADediting_1226599(111667481, -), ADediting_1226600(111667504, -), ADediting_1226601(111669372, -), ADediting_1226602(111669401, -), ADediting_1226603(111670147, -), ADediting_1226604(111698159, -), ADediting_1226605(111698230, -), ADediting_1226606(111698231, -), ADediting_1226607(111698236, -), ADediting_1226608(111698239, -), ADediting_1226609(111698245, -), ADediting_1226610(111698258, -), ADediting_1226611(111698309, -), ADediting_1226612(111698310, -), ADediting_1226613(111698311, -), ADediting_1226614(111698312, -), ADediting_1226615(111698315, -), ADediting_1226616(111698327, -), ADediting_1226617(111698346, -), ADediting_1226618(111698383, -), ADediting_1226619(111698412, -), ADediting_1226620(111698414, -), ADediting_1226621(111698422, -), ADediting_1226622(111698840, -), ADediting_1226623(111698841, -), ADediting_1226624(111698891, -), ADediting_1226625(111698903, -), ADediting_1226626(111698913, -), ADediting_1226627(111698917, -), ADediting_1226628(111698920, -), ADediting_1226629(111698926, -), ADediting_1226630(111698934, -), ADediting_1226631(111698935, -), ADediting_1226632(111698939, -), ADediting_1226633(111698959, -), ADediting_1226634(111698961, -), ADediting_1226635(111698983, -), ADediting_1226636(111698996, -), ADediting_1226637(111699020, -), ADediting_1226638(111699034, -), ADediting_1226639(111699063, -), ADediting_1226640(111699074, -), ADediting_1226641(111705484, -), ADediting_1226642(111705494, -), ADediting_1226643(111705542, -), ADediting_1226644(111705657, -), ADediting_1226645(111705749, -), ADediting_1226646(111705786, -), ADediting_1226647(111705818, -), ADediting_1226648(111705900, -), ADediting_1226649(111705936, -), ADediting_1226650(111733831, -), ADediting_1226651(111733959, -), ADediting_1226652(111739962, -), ADediting_1226653(111740006, -), ADediting_1226659(111740941, -), ADediting_1226660(111740982, -), ADediting_1226661(111740984, -), ADediting_1226662(111740994, -), ADediting_1226663(111740998, -), ADediting_1226664(111741006, -), ADediting_1226665(111741051, -), ADediting_1226670(111743043, -), ADediting_1226671(111743063, -), ADediting_1226672(111743105, -), ADediting_1226673(111743165, -), ADediting_1226674(111743166, -), ADediting_1226680(111778753, -), ADediting_1226681(111778767, -), ADediting_1226682(111866427, -), ADediting_1226683(111866439, -), ADediting_1226684(111866543, -), ADediting_1226685(111866560, -), ADediting_1226686(111866561, -), ADediting_1226687(111866588, -), ADediting_1226688(111866593, -), ADediting_1226689(111866597, -), ADediting_1226690(111867209, -), ADediting_1226691(111867220, -), ADediting_1226692(111867227, -), ADediting_1226693(111867237, -), ADediting_1226694(111867242, -), ADediting_1226695(111867255, -), ADediting_1226696(111867267, -), ADediting_1226697(111867289, -), ADediting_1226698(111867355, -), ADediting_1226699(111869476, -), ADediting_1226700(111869493, -), ADediting_1582308(111666616, -), ADediting_1582309(111666661, -), ADediting_1582310(111666698, -), ADediting_1582311(111666724, -), ADediting_1582312(111666738, -), ADediting_1582313(111666764, -), ADediting_1582314(111667322, -), ADediting_1582315(111699026, -), ADediting_1659095(111734073, -), ADediting_1659096(111866470, -), ADediting_1659097(111867268, -), |
Top |
RNA editing positional annotations for FYN using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1226543 | chr6_111665664_- | intronic |
| ADediting_1226544 | chr6_111665718_- | intronic |
| ADediting_1226545 | chr6_111665719_- | intronic |
| ADediting_1226546 | chr6_111665746_- | intronic |
| ADediting_1226547 | chr6_111665750_- | intronic |
| ADediting_1226548 | chr6_111665760_- | intronic |
| ADediting_1226549 | chr6_111665766_- | intronic |
| ADediting_1226550 | chr6_111665776_- | intronic |
| ADediting_1226551 | chr6_111665786_- | intronic |
| ADediting_1226552 | chr6_111665798_- | intronic |
| ADediting_1226553 | chr6_111665816_- | intronic |
| ADediting_1226554 | chr6_111665822_- | intronic |
| ADediting_1226555 | chr6_111665826_- | intronic |
| ADediting_1226556 | chr6_111665842_- | intronic |
| ADediting_1226557 | chr6_111665846_- | intronic |
| ADediting_1226558 | chr6_111665887_- | intronic |
| ADediting_1226559 | chr6_111665895_- | intronic |
| ADediting_1226560 | chr6_111665896_- | intronic |
| ADediting_1226561 | chr6_111666078_- | intronic |
| ADediting_1226562 | chr6_111666098_- | intronic |
| ADediting_1226563 | chr6_111666099_- | intronic |
| ADediting_1226564 | chr6_111666126_- | intronic |
| ADediting_1226565 | chr6_111666130_- | intronic |
| ADediting_1226566 | chr6_111666151_- | intronic |
| ADediting_1226567 | chr6_111666207_- | intronic |
| ADediting_1226568 | chr6_111666459_- | intronic |
| ADediting_1226569 | chr6_111666598_- | intronic |
| ADediting_1226570 | chr6_111666615_- | intronic |
| ADediting_1226571 | chr6_111666621_- | intronic |
| ADediting_1226572 | chr6_111666653_- | intronic |
| ADediting_1226573 | chr6_111666684_- | intronic |
| ADediting_1226574 | chr6_111666705_- | intronic |
| ADediting_1226575 | chr6_111666709_- | intronic |
| ADediting_1226576 | chr6_111666711_- | intronic |
| ADediting_1226577 | chr6_111666721_- | intronic |
| ADediting_1226578 | chr6_111666723_- | intronic |
| ADediting_1226579 | chr6_111666733_- | intronic |
| ADediting_1226580 | chr6_111666747_- | intronic |
| ADediting_1226581 | chr6_111666750_- | intronic |
| ADediting_1226582 | chr6_111666765_- | intronic |
| ADediting_1226583 | chr6_111666771_- | intronic |
| ADediting_1226584 | chr6_111666773_- | intronic |
| ADediting_1226585 | chr6_111666776_- | intronic |
| ADediting_1226586 | chr6_111666781_- | intronic |
| ADediting_1226587 | chr6_111666807_- | intronic |
| ADediting_1226588 | chr6_111666936_- | intronic |
| ADediting_1226589 | chr6_111667269_- | intronic |
| ADediting_1226590 | chr6_111667315_- | intronic |
| ADediting_1226591 | chr6_111667356_- | intronic |
| ADediting_1226592 | chr6_111667374_- | intronic |
| ADediting_1226593 | chr6_111667380_- | intronic |
| ADediting_1226594 | chr6_111667382_- | intronic |
| ADediting_1226595 | chr6_111667386_- | intronic |
| ADediting_1226596 | chr6_111667453_- | intronic |
| ADediting_1226597 | chr6_111667457_- | intronic |
| ADediting_1226598 | chr6_111667473_- | intronic |
| ADediting_1226599 | chr6_111667481_- | intronic |
| ADediting_1226600 | chr6_111667504_- | intronic |
| ADediting_1226601 | chr6_111669372_- | intronic |
| ADediting_1226602 | chr6_111669401_- | intronic |
| ADediting_1226603 | chr6_111670147_- | intronic |
| ADediting_1226604 | chr6_111698159_- | intronic |
| ADediting_1226605 | chr6_111698230_- | intronic |
| ADediting_1226606 | chr6_111698231_- | intronic |
| ADediting_1226607 | chr6_111698236_- | intronic |
| ADediting_1226608 | chr6_111698239_- | intronic |
| ADediting_1226609 | chr6_111698245_- | intronic |
| ADediting_1226610 | chr6_111698258_- | intronic |
| ADediting_1226611 | chr6_111698309_- | intronic |
| ADediting_1226612 | chr6_111698310_- | intronic |
| ADediting_1226613 | chr6_111698311_- | intronic |
| ADediting_1226614 | chr6_111698312_- | intronic |
| ADediting_1226615 | chr6_111698315_- | intronic |
| ADediting_1226616 | chr6_111698327_- | intronic |
| ADediting_1226617 | chr6_111698346_- | intronic |
| ADediting_1226618 | chr6_111698383_- | intronic |
| ADediting_1226619 | chr6_111698412_- | intronic |
| ADediting_1226620 | chr6_111698414_- | intronic |
| ADediting_1226621 | chr6_111698422_- | intronic |
| ADediting_1226622 | chr6_111698840_- | intronic |
| ADediting_1226623 | chr6_111698841_- | intronic |
| ADediting_1226624 | chr6_111698891_- | intronic |
| ADediting_1226625 | chr6_111698903_- | intronic |
| ADediting_1226626 | chr6_111698913_- | intronic |
| ADediting_1226627 | chr6_111698917_- | intronic |
| ADediting_1226628 | chr6_111698920_- | intronic |
| ADediting_1226629 | chr6_111698926_- | intronic |
| ADediting_1226630 | chr6_111698934_- | intronic |
| ADediting_1226631 | chr6_111698935_- | intronic |
| ADediting_1226632 | chr6_111698939_- | intronic |
| ADediting_1226633 | chr6_111698959_- | intronic |
| ADediting_1226634 | chr6_111698961_- | intronic |
| ADediting_1226635 | chr6_111698983_- | intronic |
| ADediting_1226636 | chr6_111698996_- | intronic |
| ADediting_1226637 | chr6_111699020_- | intronic |
| ADediting_1226638 | chr6_111699034_- | intronic |
| ADediting_1226639 | chr6_111699063_- | intronic |
| ADediting_1226640 | chr6_111699074_- | intronic |
| ADediting_1226641 | chr6_111705484_- | intronic |
| ADediting_1226642 | chr6_111705494_- | intronic |
| ADediting_1226643 | chr6_111705542_- | intronic |
| ADediting_1226644 | chr6_111705657_- | intronic |
| ADediting_1226645 | chr6_111705749_- | intronic |
| ADediting_1226646 | chr6_111705786_- | intronic |
| ADediting_1226647 | chr6_111705818_- | intronic |
| ADediting_1226648 | chr6_111705900_- | intronic |
| ADediting_1226649 | chr6_111705936_- | intronic |
| ADediting_1226650 | chr6_111733831_- | intronic |
| ADediting_1226651 | chr6_111733959_- | intronic |
| ADediting_1226652 | chr6_111739962_- | intronic |
| ADediting_1226653 | chr6_111740006_- | intronic |
| ADediting_1226659 | chr6_111740941_- | intronic |
| ADediting_1226660 | chr6_111740982_- | UTR5 |
| ADediting_1226661 | chr6_111740984_- | UTR5 |
| ADediting_1226662 | chr6_111740994_- | UTR5 |
| ADediting_1226663 | chr6_111740998_- | UTR5 |
| ADediting_1226664 | chr6_111741006_- | UTR5 |
| ADediting_1226665 | chr6_111741051_- | UTR5 |
| ADediting_1226670 | chr6_111743043_- | intronic |
| ADediting_1226671 | chr6_111743063_- | intronic |
| ADediting_1226672 | chr6_111743105_- | intronic |
| ADediting_1226673 | chr6_111743165_- | intronic |
| ADediting_1226674 | chr6_111743166_- | intronic |
| ADediting_1226680 | chr6_111778753_- | intronic |
| ADediting_1226681 | chr6_111778767_- | intronic |
| ADediting_1226682 | chr6_111866427_- | intronic |
| ADediting_1226683 | chr6_111866439_- | intronic |
| ADediting_1226684 | chr6_111866543_- | intronic |
| ADediting_1226685 | chr6_111866560_- | intronic |
| ADediting_1226686 | chr6_111866561_- | intronic |
| ADediting_1226687 | chr6_111866588_- | intronic |
| ADediting_1226688 | chr6_111866593_- | intronic |
| ADediting_1226689 | chr6_111866597_- | intronic |
| ADediting_1226690 | chr6_111867209_- | intronic |
| ADediting_1226691 | chr6_111867220_- | intronic |
| ADediting_1226692 | chr6_111867227_- | intronic |
| ADediting_1226693 | chr6_111867237_- | intronic |
| ADediting_1226694 | chr6_111867242_- | intronic |
| ADediting_1226695 | chr6_111867255_- | intronic |
| ADediting_1226696 | chr6_111867267_- | intronic |
| ADediting_1226697 | chr6_111867289_- | intronic |
| ADediting_1226698 | chr6_111867355_- | intronic |
| ADediting_1226699 | chr6_111869476_- | intronic |
| ADediting_1226700 | chr6_111869493_- | intronic |
| ADediting_1582308 | chr6_111666616_- | intronic |
| ADediting_1582309 | chr6_111666661_- | intronic |
| ADediting_1582310 | chr6_111666698_- | intronic |
| ADediting_1582311 | chr6_111666724_- | intronic |
| ADediting_1582312 | chr6_111666738_- | intronic |
| ADediting_1582313 | chr6_111666764_- | intronic |
| ADediting_1582314 | chr6_111667322_- | intronic |
| ADediting_1582315 | chr6_111699026_- | intronic |
| ADediting_1659095 | chr6_111734073_- | intronic |
| ADediting_1659096 | chr6_111866470_- | intronic |
| ADediting_1659097 | chr6_111867268_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1226543 | chr6_111665664_- | SINE | Alu | Name=AluSz |
| ADediting_1226544 | chr6_111665718_- | SINE | Alu | Name=AluSz |
| ADediting_1226545 | chr6_111665719_- | SINE | Alu | Name=AluSz |
| ADediting_1226546 | chr6_111665746_- | SINE | Alu | Name=AluSz |
| ADediting_1226547 | chr6_111665750_- | SINE | Alu | Name=AluSz |
| ADediting_1226548 | chr6_111665760_- | SINE | Alu | Name=AluSz |
| ADediting_1226549 | chr6_111665766_- | SINE | Alu | Name=AluSz |
| ADediting_1226550 | chr6_111665776_- | SINE | Alu | Name=AluSz |
| ADediting_1226551 | chr6_111665786_- | SINE | Alu | Name=AluSz |
| ADediting_1226552 | chr6_111665798_- | SINE | Alu | Name=AluSz |
| ADediting_1226553 | chr6_111665816_- | SINE | Alu | Name=AluSz |
| ADediting_1226554 | chr6_111665822_- | SINE | Alu | Name=AluSz |
| ADediting_1226555 | chr6_111665826_- | SINE | Alu | Name=AluSz |
| ADediting_1226556 | chr6_111665842_- | SINE | Alu | Name=AluSz |
| ADediting_1226557 | chr6_111665846_- | SINE | Alu | Name=AluSz |
| ADediting_1226558 | chr6_111665887_- | SINE | Alu | Name=AluSz |
| ADediting_1226559 | chr6_111665895_- | SINE | Alu | Name=AluSz |
| ADediting_1226560 | chr6_111665896_- | SINE | Alu | Name=AluSz |
| ADediting_1226561 | chr6_111666078_- | SINE | Alu | Name=AluSz6 |
| ADediting_1226562 | chr6_111666098_- | SINE | Alu | Name=AluSz6 |
| ADediting_1226563 | chr6_111666099_- | SINE | Alu | Name=AluSz6 |
| ADediting_1226564 | chr6_111666126_- | SINE | Alu | Name=AluSz6 |
| ADediting_1226565 | chr6_111666130_- | SINE | Alu | Name=AluSz6 |
| ADediting_1226569 | chr6_111666598_- | SINE | Alu | Name=AluJb |
| ADediting_1226570 | chr6_111666615_- | SINE | Alu | Name=AluJb |
| ADediting_1226571 | chr6_111666621_- | SINE | Alu | Name=AluJb |
| ADediting_1226572 | chr6_111666653_- | SINE | Alu | Name=AluJb |
| ADediting_1226573 | chr6_111666684_- | SINE | Alu | Name=AluJb |
| ADediting_1226574 | chr6_111666705_- | SINE | Alu | Name=AluJb |
| ADediting_1226575 | chr6_111666709_- | SINE | Alu | Name=AluJb |
| ADediting_1226576 | chr6_111666711_- | SINE | Alu | Name=AluJb |
| ADediting_1226577 | chr6_111666721_- | SINE | Alu | Name=AluJb |
| ADediting_1226578 | chr6_111666723_- | SINE | Alu | Name=AluJb |
| ADediting_1226579 | chr6_111666733_- | SINE | Alu | Name=AluJb |
| ADediting_1226580 | chr6_111666747_- | SINE | Alu | Name=AluJb |
| ADediting_1226581 | chr6_111666750_- | SINE | Alu | Name=AluJb |
| ADediting_1226582 | chr6_111666765_- | SINE | Alu | Name=AluJb |
| ADediting_1226583 | chr6_111666771_- | SINE | Alu | Name=AluJb |
| ADediting_1226584 | chr6_111666773_- | SINE | Alu | Name=AluJb |
| ADediting_1226585 | chr6_111666776_- | SINE | Alu | Name=AluJb |
| ADediting_1226586 | chr6_111666781_- | SINE | Alu | Name=AluJb |
| ADediting_1226587 | chr6_111666807_- | SINE | Alu | Name=AluJb |
| ADediting_1226589 | chr6_111667269_- | SINE | Alu | Name=AluJr |
| ADediting_1226590 | chr6_111667315_- | SINE | Alu | Name=AluJr |
| ADediting_1226591 | chr6_111667356_- | SINE | Alu | Name=AluJr |
| ADediting_1226592 | chr6_111667374_- | SINE | Alu | Name=AluJr |
| ADediting_1226593 | chr6_111667380_- | SINE | Alu | Name=AluJr |
| ADediting_1226594 | chr6_111667382_- | SINE | Alu | Name=AluJr |
| ADediting_1226595 | chr6_111667386_- | SINE | Alu | Name=AluJr |
| ADediting_1226596 | chr6_111667453_- | SINE | Alu | Name=AluJr |
| ADediting_1226597 | chr6_111667457_- | SINE | Alu | Name=AluJr |
| ADediting_1226598 | chr6_111667473_- | SINE | Alu | Name=AluJr |
| ADediting_1226599 | chr6_111667481_- | SINE | Alu | Name=AluJr |
| ADediting_1226600 | chr6_111667504_- | SINE | Alu | Name=AluJr |
| ADediting_1226601 | chr6_111669372_- | SINE | Alu | Name=AluSx1 |
| ADediting_1226602 | chr6_111669401_- | SINE | Alu | Name=AluSx1 |
| ADediting_1226603 | chr6_111670147_- | LINE | L2 | Name=L2a |
| ADediting_1226604 | chr6_111698159_- | SINE | Alu | Name=AluSp |
| ADediting_1226605 | chr6_111698230_- | SINE | Alu | Name=AluSp |
| ADediting_1226606 | chr6_111698231_- | SINE | Alu | Name=AluSp |
| ADediting_1226607 | chr6_111698236_- | SINE | Alu | Name=AluSp |
| ADediting_1226608 | chr6_111698239_- | SINE | Alu | Name=AluSp |
| ADediting_1226609 | chr6_111698245_- | SINE | Alu | Name=AluSp |
| ADediting_1226610 | chr6_111698258_- | SINE | Alu | Name=AluSp |
| ADediting_1226611 | chr6_111698309_- | SINE | Alu | Name=AluSp |
| ADediting_1226612 | chr6_111698310_- | SINE | Alu | Name=AluSp |
| ADediting_1226613 | chr6_111698311_- | SINE | Alu | Name=AluSp |
| ADediting_1226614 | chr6_111698312_- | SINE | Alu | Name=AluSp |
| ADediting_1226615 | chr6_111698315_- | SINE | Alu | Name=AluSp |
| ADediting_1226616 | chr6_111698327_- | SINE | Alu | Name=AluSp |
| ADediting_1226617 | chr6_111698346_- | SINE | Alu | Name=AluSp |
| ADediting_1226618 | chr6_111698383_- | SINE | Alu | Name=AluSp |
| ADediting_1226619 | chr6_111698412_- | SINE | Alu | Name=AluSp |
| ADediting_1226620 | chr6_111698414_- | SINE | Alu | Name=AluSp |
| ADediting_1226621 | chr6_111698422_- | SINE | Alu | Name=AluSp |
| ADediting_1226622 | chr6_111698840_- | SINE | Alu | Name=AluSc |
| ADediting_1226623 | chr6_111698841_- | SINE | Alu | Name=AluSc |
| ADediting_1226624 | chr6_111698891_- | SINE | Alu | Name=AluSc |
| ADediting_1226625 | chr6_111698903_- | SINE | Alu | Name=AluSc |
| ADediting_1226626 | chr6_111698913_- | SINE | Alu | Name=AluSc |
| ADediting_1226627 | chr6_111698917_- | SINE | Alu | Name=AluSc |
| ADediting_1226628 | chr6_111698920_- | SINE | Alu | Name=AluSc |
| ADediting_1226629 | chr6_111698926_- | SINE | Alu | Name=AluSc |
| ADediting_1226630 | chr6_111698934_- | SINE | Alu | Name=AluSc |
| ADediting_1226631 | chr6_111698935_- | SINE | Alu | Name=AluSc |
| ADediting_1226632 | chr6_111698939_- | SINE | Alu | Name=AluSc |
| ADediting_1226633 | chr6_111698959_- | SINE | Alu | Name=AluSc |
| ADediting_1226634 | chr6_111698961_- | SINE | Alu | Name=AluSc |
| ADediting_1226635 | chr6_111698983_- | SINE | Alu | Name=AluSc |
| ADediting_1226636 | chr6_111698996_- | SINE | Alu | Name=AluSc |
| ADediting_1226637 | chr6_111699020_- | SINE | Alu | Name=AluSc |
| ADediting_1226638 | chr6_111699034_- | SINE | Alu | Name=AluSc |
| ADediting_1226639 | chr6_111699063_- | SINE | Alu | Name=AluSc |
| ADediting_1226640 | chr6_111699074_- | SINE | Alu | Name=AluSc |
| ADediting_1226641 | chr6_111705484_- | SINE | Alu | Name=AluJo |
| ADediting_1226642 | chr6_111705494_- | SINE | Alu | Name=AluJo |
| ADediting_1226643 | chr6_111705542_- | SINE | Alu | Name=AluJo |
| ADediting_1226644 | chr6_111705657_- | SINE | Alu | Name=AluSx |
| ADediting_1226645 | chr6_111705749_- | SINE | Alu | Name=AluSx |
| ADediting_1226646 | chr6_111705786_- | SINE | Alu | Name=AluSx |
| ADediting_1226647 | chr6_111705818_- | SINE | Alu | Name=AluSx |
| ADediting_1226648 | chr6_111705900_- | SINE | Alu | Name=AluJo |
| ADediting_1226649 | chr6_111705936_- | SINE | Alu | Name=AluJo |
| ADediting_1226650 | chr6_111733831_- | SINE | Alu | Name=AluJb |
| ADediting_1226651 | chr6_111733959_- | SINE | Alu | Name=AluJb |
| ADediting_1226652 | chr6_111739962_- | SINE | Alu | Name=AluSg7 |
| ADediting_1226653 | chr6_111740006_- | SINE | Alu | Name=AluSg7 |
| ADediting_1226659 | chr6_111740941_- | SINE | Alu | Name=AluJb |
| ADediting_1226660 | chr6_111740982_- | SINE | Alu | Name=AluJb |
| ADediting_1226661 | chr6_111740984_- | SINE | Alu | Name=AluJb |
| ADediting_1226662 | chr6_111740994_- | SINE | Alu | Name=AluJb |
| ADediting_1226663 | chr6_111740998_- | SINE | Alu | Name=AluJb |
| ADediting_1226664 | chr6_111741006_- | SINE | Alu | Name=AluJb |
| ADediting_1226665 | chr6_111741051_- | SINE | Alu | Name=AluJb |
| ADediting_1226670 | chr6_111743043_- | SINE | Alu | Name=AluSg |
| ADediting_1226671 | chr6_111743063_- | SINE | Alu | Name=AluSg |
| ADediting_1226672 | chr6_111743105_- | SINE | Alu | Name=AluSg |
| ADediting_1226673 | chr6_111743165_- | SINE | Alu | Name=AluSg |
| ADediting_1226674 | chr6_111743166_- | SINE | Alu | Name=AluSg |
| ADediting_1226680 | chr6_111778753_- | SINE | Alu | Name=AluSc8 |
| ADediting_1226681 | chr6_111778767_- | SINE | Alu | Name=AluSc8 |
| ADediting_1226682 | chr6_111866427_- | SINE | Alu | Name=AluSx |
| ADediting_1226683 | chr6_111866439_- | SINE | Alu | Name=AluSx |
| ADediting_1226684 | chr6_111866543_- | SINE | Alu | Name=AluSx |
| ADediting_1226685 | chr6_111866560_- | SINE | Alu | Name=AluSx |
| ADediting_1226686 | chr6_111866561_- | SINE | Alu | Name=AluSx |
| ADediting_1226687 | chr6_111866588_- | SINE | Alu | Name=AluSx |
| ADediting_1226688 | chr6_111866593_- | SINE | Alu | Name=AluSx |
| ADediting_1226689 | chr6_111866597_- | SINE | Alu | Name=AluSx |
| ADediting_1226690 | chr6_111867209_- | SINE | Alu | Name=AluSq2 |
| ADediting_1226691 | chr6_111867220_- | SINE | Alu | Name=AluSq2 |
| ADediting_1226692 | chr6_111867227_- | SINE | Alu | Name=AluSq2 |
| ADediting_1226693 | chr6_111867237_- | SINE | Alu | Name=AluSq2 |
| ADediting_1226694 | chr6_111867242_- | SINE | Alu | Name=AluSq2 |
| ADediting_1226695 | chr6_111867255_- | SINE | Alu | Name=AluSq2 |
| ADediting_1226696 | chr6_111867267_- | SINE | Alu | Name=AluSq2 |
| ADediting_1226697 | chr6_111867289_- | SINE | Alu | Name=AluSq2 |
| ADediting_1226698 | chr6_111867355_- | SINE | Alu | Name=AluSq2 |
| ADediting_1226699 | chr6_111869476_- | SINE | Alu | Name=AluJb |
| ADediting_1226700 | chr6_111869493_- | SINE | Alu | Name=AluJb |
| ADediting_1582308 | chr6_111666616_- | SINE | Alu | Name=AluJb |
| ADediting_1582309 | chr6_111666661_- | SINE | Alu | Name=AluJb |
| ADediting_1582310 | chr6_111666698_- | SINE | Alu | Name=AluJb |
| ADediting_1582311 | chr6_111666724_- | SINE | Alu | Name=AluJb |
| ADediting_1582312 | chr6_111666738_- | SINE | Alu | Name=AluJb |
| ADediting_1582313 | chr6_111666764_- | SINE | Alu | Name=AluJb |
| ADediting_1582314 | chr6_111667322_- | SINE | Alu | Name=AluJr |
| ADediting_1582315 | chr6_111699026_- | SINE | Alu | Name=AluSc |
| ADediting_1659095 | chr6_111734073_- | SINE | Alu | Name=AluJb |
| ADediting_1659096 | chr6_111866470_- | SINE | Alu | Name=AluSx |
| ADediting_1659097 | chr6_111867268_- | SINE | Alu | Name=AluSq2 |
Top |
RNA A-to-I editing events in the alternative splicing sites for FYN |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| ES | ADediting_1226660 | chr6_111740982_- | 111740975:111740983 | 5ss | 2e | CAGGTGAGC | 9.60 | CGGGTGAGC | 8.19 |
| ES | ADediting_1226660 | chr6_111740982_- | 111740975:111740983 | 5ss | 2e | CAGGTGAGC | 9.60 | CGGGTGAGC | 8.19 |
| ME2 | ADediting_1226660 | chr6_111740982_- | 111740975:111740983 | 5ss | 2e | CAGGTGAGC | 9.60 | CGGGTGAGC | 8.19 |
| ME2 | ADediting_1226660 | chr6_111740982_- | 111740975:111740983 | 5ss | 2e | CAGGTGAGC | 9.60 | CGGGTGAGC | 8.19 |
| ME2 | ADediting_1226660 | chr6_111740982_- | 111740975:111740983 | 5ss | 2e | CAGGTGAGC | 9.60 | CGGGTGAGC | 8.19 |
| ME2 | ADediting_1226660 | chr6_111740982_- | 111740975:111740983 | 5ss | 2e | CAGGTGAGC | 9.60 | CGGGTGAGC | 8.19 |
| ME2 | ADediting_1226660 | chr6_111740982_- | 111740975:111740983 | 5ss | 2e | CAGGTGAGC | 9.60 | CGGGTGAGC | 8.19 |
| ME2 | ADediting_1226660 | chr6_111740982_- | 111740975:111740983 | 5ss | 2e | CAGGTGAGC | 9.60 | CGGGTGAGC | 8.19 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for FYN |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for FYN |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for FYN |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1631458 | chr19_40282624_- | ENSG00000010810.17 | ENST00000354650.7 | FYN-202 | hsa-miR-641 | chr6 | 111660643 | 111660649 | 7mer-m8 | 111660642 | 111660665 | 148 | -13.29 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000010810.17 | ENST00000368682.7 | FYN-205 | hsa-miR-641 | chr6 | 111660643 | 111660649 | 7mer-m8 | 111660642 | 111660665 | 148 | -13.29 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000010810.17 | ENST00000538466.5 | FYN-229 | hsa-miR-641 | chr6 | 111660643 | 111660649 | 7mer-m8 | 111660642 | 111660665 | 148 | -13.29 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000010810.17 | ENST00000354650.7 | FYN-202 | hsa-miR-381-3p | chr6 | 111660834 | 111660841 | 8mer-1a | 111660834 | 111660855 | 142 | -10.45 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000010810.17 | ENST00000368682.7 | FYN-205 | hsa-miR-381-3p | chr6 | 111660834 | 111660841 | 8mer-1a | 111660834 | 111660855 | 142 | -10.45 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000010810.17 | ENST00000538466.5 | FYN-229 | hsa-miR-381-3p | chr6 | 111660834 | 111660841 | 8mer-1a | 111660834 | 111660855 | 142 | -10.45 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000010810.17 | ENST00000354650.7 | FYN-202 | hsa-miR-381-3p | chr6 | 111660834 | 111660841 | 8mer-1a | 111660834 | 111660855 | 142 | -10.45 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000010810.17 | ENST00000368682.7 | FYN-205 | hsa-miR-381-3p | chr6 | 111660834 | 111660841 | 8mer-1a | 111660834 | 111660855 | 142 | -10.45 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000010810.17 | ENST00000538466.5 | FYN-229 | hsa-miR-381-3p | chr6 | 111660834 | 111660841 | 8mer-1a | 111660834 | 111660855 | 142 | -10.45 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000010810.17 | ENST00000354650.7 | FYN-202 | hsa-miR-5682 | chr6 | 111661192 | 111661199 | 8mer-1a | 111661192 | 111661214 | 149 | -12.59 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000010810.17 | ENST00000368682.7 | FYN-205 | hsa-miR-5682 | chr6 | 111661192 | 111661199 | 8mer-1a | 111661192 | 111661214 | 149 | -12.59 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000010810.17 | ENST00000538466.5 | FYN-229 | hsa-miR-5682 | chr6 | 111661192 | 111661199 | 8mer-1a | 111661192 | 111661214 | 149 | -12.59 |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for FYN |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000520518.5 | protein_coding |  |  |
| ENST00000518295.5 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1226660 | ENST00000520518.5 | chr6_111740982_- | 293 | -287.10 | -287.80 | -291.30 |
| ADediting_1226661 | ENST00000520518.5 | chr6_111740984_- | 291 | -289.10 | -287.80 | -291.30 |
| ADediting_1226662 | ENST00000520518.5 | chr6_111740994_- | 281 | -290.00 | -287.80 | -291.30 |
| ADediting_1226663 | ENST00000520518.5 | chr6_111740998_- | 277 | -288.20 | -287.80 | -291.30 |
| ADediting_1226664 | ENST00000520518.5 | chr6_111741006_- | 269 | -288.80 | -287.80 | -291.30 |
| ADediting_1226665 | ENST00000520518.5 | chr6_111741051_- | 224 | -287.10 | -287.80 | -291.30 |
| ADediting_1226660 | ENST00000518295.5 | chr6_111740982_- | 541 | -417.10 | -417.80 | -420.90 |
| ADediting_1226661 | ENST00000518295.5 | chr6_111740984_- | 539 | -418.00 | -417.80 | -420.90 |
| ADediting_1226662 | ENST00000518295.5 | chr6_111740994_- | 529 | -418.90 | -417.80 | -420.90 |
| ADediting_1226663 | ENST00000518295.5 | chr6_111740998_- | 525 | -418.20 | -417.80 | -420.90 |
| ADediting_1226664 | ENST00000518295.5 | chr6_111741006_- | 517 | -418.50 | -417.80 | -420.90 |
| ADediting_1226665 | ENST00000518295.5 | chr6_111741051_- | 472 | -418.10 | -417.80 | -420.90 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for FYN |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1226544 | chr6_111665718_- | 0.000133445275667129 | 0.306908464562789 | 2.74476030988902e-06 | 0.372130826063769 | 0.0153053334166912 | 0.197701754352901 |
| CER | ADediting_1226547 | chr6_111665750_- | 0.000408159180998748 | 0.284986646775125 | 8.24211179003582e-06 | 0.35509368700872 | 0.170775012187775 | 0.112422576337128 |
| CER | ADediting_1226548 | chr6_111665760_- | 9.12354727933445e-05 | 0.313986781924915 | 2.6327981598333e-07 | 0.405522934276816 | 0.000170034333515562 | 0.30230267078116 |
| CER | ADediting_1226549 | chr6_111665766_- | 1.37524165997599e-05 | 0.346814180736084 | 3.11584505791784e-09 | 0.460229013860294 | 0.000477467634320321 | 0.281765563469592 |
| TCX | ADediting_1226554 | chr6_111665822_- | 0.0559938078244174 | 0.156386102967217 | 0.240480856973102 | -0.0964223314609232 | 2.22328397118923e-09 | 0.464020871527387 |
| TCX | ADediting_1226556 | chr6_111665842_- | 0.0888738518281494 | 0.13940316968176 | 0.515690030948336 | -0.0534819536360413 | 1.48669735299899e-05 | 0.345533211742552 |
| TCX | ADediting_1226560 | chr6_111665896_- | 0.154033745632222 | 0.116964225978405 | 0.223279952188253 | -0.100024425957034 | 1.2322537302928e-05 | 0.348609373151322 |
| DLPFC | ADediting_1226568 | chr6_111666459_- | 0.000329081584530468 | 0.202667948478184 | 7.27463178595821e-09 | 0.321092196192641 | 0.0438356580676461 | 0.114567343357952 |
| CER | ADediting_1226569 | chr6_111666598_- | 1.46407322404261e-05 | 0.345785725147237 | 1.71034824510499e-05 | 0.343215405037553 | 0.021551245334928 | 0.187546715689461 |
| CER | ADediting_1226574 | chr6_111666705_- | 7.40788906208292e-05 | 0.317790466316841 | 8.88717771041089e-06 | 0.353889562244117 | 0.0288176849379525 | 0.17854077565622 |
| TCX | ADediting_1226574 | chr6_111666705_- | 0.960406364657708 | -0.00408756433460944 | 0.00955179535870159 | -0.210984451308217 | 8.30323907656182e-05 | 0.315713395733885 |
| CER | ADediting_1226576 | chr6_111666711_- | 5.7320905063171e-07 | 0.394842037060008 | 1.57490480809453e-06 | 0.380382726130949 | 0.473764142181466 | 0.0589333426857333 |
| CER | ADediting_1226577 | chr6_111666721_- | 3.03549632014861e-07 | 0.403596728890887 | 2.19645231129793e-05 | 0.339031880590701 | 0.00354245264854256 | 0.236699189507085 |
| TCX | ADediting_1226577 | chr6_111666721_- | 0.663960363874104 | -0.0357606479115474 | 0.00289624276378882 | -0.241604555614019 | 2.03080505822036e-05 | 0.340349725681763 |
| CER | ADediting_1226578 | chr6_111666723_- | 0.000164694160550496 | 0.3029135914833 | 0.000901699987901648 | 0.268295825978007 | 0.374226404997186 | 0.0730668227297646 |
| CER | ADediting_1226583 | chr6_111666771_- | 0.000176197934636854 | 0.30161937297851 | 0.00374882066122954 | 0.235302455655079 | 0.217403939977248 | 0.101299774870142 |
| CER | ADediting_1226584 | chr6_111666773_- | 1.34944005851911e-07 | 0.414409876379936 | 4.11772566425372e-07 | 0.399428708326441 | 0.00229430980365391 | 0.247161445590011 |
| TCX | ADediting_1226584 | chr6_111666773_- | 0.568230551898191 | -0.046961278311887 | 0.000396693201332553 | -0.285567743207837 | 1.53555158585266e-05 | 0.345000083349657 |
| CER | ADediting_1226585 | chr6_111666776_- | 5.40767979374524e-08 | 0.42616768705622 | 5.24725567558275e-07 | 0.39607423728152 | 0.00120809476481471 | 0.26185997738828 |
| TCX | ADediting_1226585 | chr6_111666776_- | 0.962934821466686 | 0.0038263392969532 | 0.000900114398881546 | -0.268334073990201 | 4.73888899679887e-05 | 0.32578001773729 |
| CER | ADediting_1226586 | chr6_111666781_- | 1.14817005493416e-07 | 0.416519549229435 | 1.33390087404416e-07 | 0.414561636493508 | 0.00182726449163483 | 0.252474706926948 |
| TCX | ADediting_1226586 | chr6_111666781_- | 0.370443223092309 | -0.0736456936655002 | 0.000173088910174129 | -0.301961208898463 | 0.000122321857459622 | 0.308544460385775 |
| CER | ADediting_1226591 | chr6_111667356_- | 0.000429108062215604 | 0.283962883525445 | 0.000175386823007976 | 0.301708009723773 | 0.464823496820148 | 0.0601289506693012 |
| CER | ADediting_1226593 | chr6_111667380_- | 4.13762351995862e-07 | 0.399362357157693 | 6.76321973514909e-09 | 0.451342980784732 | 0.00288822597651109 | 0.241671395969746 |
| TCX | ADediting_1226593 | chr6_111667380_- | 0.0339146342549385 | 0.173322827851868 | 0.344630904869395 | -0.0776966457000431 | 4.11289763998132e-06 | 0.365976970414609 |
| CER | ADediting_1226594 | chr6_111667382_- | 2.13247069652733e-06 | 0.375908472725117 | 4.15855171492774e-07 | 0.399292898203371 | 0.00525627636011431 | 0.226795602240963 |
| TCX | ADediting_1226594 | chr6_111667382_- | 0.000880171110315284 | 0.268820503969048 | 0.933552438332787 | -0.00686498431314623 | 7.11654930410296e-06 | 0.357426066733674 |
| CER | ADediting_1226598 | chr6_111667473_- | 7.48468307821516e-05 | 0.317603351025268 | 3.82577947613912e-06 | 0.367087424883243 | 0.0259428902265785 | 0.181841534509314 |
| TCX | ADediting_1226619 | chr6_111698412_- | 0.00667980280514775 | 0.220577111708797 | 0.315198455536885 | -0.082557322150108 | 7.08011184372464e-14 | 0.562218755052522 |
| TCX | ADediting_1226620 | chr6_111698414_- | 0.0320746747401945 | 0.175124483242043 | 0.175169680095123 | -0.111285626383536 | 7.10711674907560e-10 | 0.476501763366497 |
| TCX | ADediting_1226621 | chr6_111698422_- | 0.332816410132086 | 0.0796145557243192 | 0.0838353680440131 | -0.141632601458681 | 1.20996059730625e-07 | 0.415836478368148 |
| TCX | ADediting_1226622 | chr6_111698840_- | 0.0950911285847347 | 0.136787019171029 | 0.257508980408428 | -0.0930293679738145 | 8.7812227670818e-09 | 0.44829086886827 |
| DLPFC | ADediting_1226648 | chr6_111705900_- | 0.239885876572107 | -0.0669465072117825 | 0.0112745061392149 | -0.143758113823501 | 1.78171417160329e-12 | 0.386351005095904 |
| DLPFC | ADediting_1226680 | chr6_111778753_- | 0.00355904700054582 | 0.165079718347633 | 0.664374759514711 | 0.0247389599115764 | 4.54698711498043e-20 | 0.489328414368548 |
| DLPFC | ADediting_1226682 | chr6_111866427_- | 0.900602112943824 | -0.00712257023837369 | 0.192017959630312 | -0.0742958477820643 | 6.41013348745748e-08 | 0.301153123868263 |
| DLPFC | ADediting_1226685 | chr6_111866560_- | 0.650031277484061 | 0.0258696866173974 | 0.0487634220018827 | -0.112025655439767 | 1.85835188506066e-10 | 0.351730455837743 |
| DLPFC | ADediting_1226686 | chr6_111866561_- | 0.975087816470823 | -0.00178081630330027 | 0.0327293374704325 | -0.121323649401675 | 9.72956991970162e-10 | 0.338313919043023 |
| DLPFC | ADediting_1226693 | chr6_111867237_- | 0.688760203338508 | 0.0228383309888605 | 0.153404388309867 | -0.0812768884180422 | 2.11296017240229e-09 | 0.331801521935718 |
| DLPFC | ADediting_1226694 | chr6_111867242_- | 0.281410192623533 | 0.0613686333542371 | 0.218210103150071 | -0.0701304040360346 | 5.3991966016509e-16 | 0.438436073121363 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 3.44993719712764e-29 | 0.579378269055474 | 3.973432634525e-19 | 0.478301072689507 | 1.49294600420042e-30 | 0.590768380383892 |
| AC | 2.21752544134512e-58 | 0.805885407920792 | 4.67602990324113e-29 | 0.630006487047723 | 1.40462277978285e-31 | 0.651423024357015 |
| PCC | 3.08383163837745e-17 | 0.561143226370238 | 8.43736676687371e-13 | 0.48759736385946 | 2.35256201482018e-09 | 0.415140880463289 |
| CER | 1.50258613127339e-43 | 0.852560560134565 | 7.91559253405803e-31 | 0.771200179782378 | 5.16470133562722e-10 | 0.479907500109907 |
| TCX | 1.78286741876025e-15 | 0.590648581131277 | 0.0840008720966528 | 0.141557688153408 | 4.18161264964117e-16 | 0.601127984131204 |
| FP | 3.42200208559079e-18 | 0.591667844779984 | 4.56842499081574e-06 | 0.335893513716349 | 2.17842872075833e-16 | 0.564807261863754 |
| IFG | 9.93195980459961e-06 | 0.761208349597883 | 9.26786236948897e-05 | 0.701729914157734 | 0.00296470358378883 | 0.569483158009785 |
| PG | 9.16106021786449e-38 | 0.770075248078548 | 1.92443122714427e-14 | 0.522866630829051 | 0.00499529916662465 | 0.205034610538754 |
| STG | 1.68698150123744e-11 | 0.652943611872229 | 0.00267671321901753 | 0.323597655206904 | 3.91141059235808e-05 | 0.432888128038269 |
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Relation with AD stages for FYN |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_1226544 | chr6_111665718_- | 0.00138457891379651 | 0.303935911243634 |
| CER | ADediting_1226548 | chr6_111665760_- | 0.00156893312364083 | 0.300654518068998 |
| CER | ADediting_1226549 | chr6_111665766_- | 0.000511095662387708 | 0.328846406168759 |
| CER | ADediting_1226574 | chr6_111666705_- | 3.97537342517401e-06 | 0.427345631938828 |
| CER | ADediting_1226584 | chr6_111666773_- | 0.000637247758834088 | 0.323512581666094 |
| CER | ADediting_1226586 | chr6_111666781_- | 0.000219930233521592 | 0.348394048852623 |
| CER | ADediting_1226593 | chr6_111667380_- | 0.000751757997656349 | 0.319452491275512 |
| CER | ADediting_1226594 | chr6_111667382_- | 0.00111013451836178 | 0.309645057476172 |
| CER | ADediting_1226598 | chr6_111667473_- | 0.000949710749853193 | 0.313611644590799 |
| TCX | ADediting_1226548 | chr6_111665760_- | 0.00027497239574602 | 0.346435069014981 |
| TCX | ADediting_1226558 | chr6_111665887_- | 0.000898188137523487 | 0.317887174164996 |
| TCX | ADediting_1226560 | chr6_111665896_- | 0.000212453635608219 | 0.352309724492029 |
| TCX | ADediting_1226566 | chr6_111666151_- | 0.000911340146138418 | 0.317518845260924 |
| TCX | ADediting_1226593 | chr6_111667380_- | 0.000633435613028933 | 0.326599402228801 |
| TCX | ADediting_1226594 | chr6_111667382_- | 0.000642561073167116 | 0.326247588105185 |
| TCX | ADediting_1226619 | chr6_111698412_- | 0.00115344970118175 | 0.311483491352572 |
| TCX | ADediting_1226622 | chr6_111698840_- | 0.000264619309484326 | 0.347316413655474 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 1.2653353643413e-07 | 0.482169025089598 |
| TCX | 4.5770053757854e-11 | 0.584929345676829 |
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RelatedDrugs for FYN |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| FYN | P06241 | DB01254 | Dasatinib | Tyrosine-protein kinase Fyn | small molecule | approved|investigational |
| FYN | P06241 | DB12010 | Fostamatinib | Tyrosine-protein kinase Fyn | small molecule | approved|investigational |
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RelatedDiseases for FYN |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| FYN | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| FYN | C0036341 | Schizophrenia | 2 | PSYGENET |
| FYN | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
| FYN | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| FYN | C0007370 | Catalepsy | 1 | CTD_human |
| FYN | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
| FYN | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| FYN | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
| FYN | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| FYN | C0079774 | Peripheral T-Cell Lymphoma | 1 | CTD_human |
| FYN | C0085762 | Alcohol abuse | 1 | PSYGENET |
| FYN | C0233612 | Waxy flexibility | 1 | CTD_human |
| FYN | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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