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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for RNASEH1 |
 Gene summary |
| Gene information | Gene symbol | RNASEH1 | Gene ID | 246243 |
| Gene name | ribonuclease H1 | |
| Synonyms | H1RNA|PEOB2|RNH1 | |
| Cytomap | 2p25.3 | |
| Type of gene | protein-coding | |
| Description | ribonuclease H1ribonuclease H type II | |
| Modification date | 20200313 | |
| UniProtAcc | O60930, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for RNASEH1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_870745(3541896, -), ADediting_870746(3541908, -), ADediting_870747(3541909, -), ADediting_870748(3541910, -), ADediting_870749(3541931, -), ADediting_870750(3541935, -), ADediting_870751(3541936, -), ADediting_870752(3541948, -), ADediting_870753(3541949, -), ADediting_870754(3541950, -), ADediting_870755(3541961, -), ADediting_870756(3541981, -), ADediting_870757(3541987, -), ADediting_870758(3543841, -), ADediting_870759(3543851, -), ADediting_870760(3543878, -), ADediting_870761(3543886, -), ADediting_870762(3543887, -), ADediting_870763(3544842, -), ADediting_870764(3544877, -), ADediting_870765(3544896, -), ADediting_870766(3544913, -), ADediting_870767(3545012, -), ADediting_870768(3545017, -), ADediting_870769(3545025, -), ADediting_870770(3545026, -), ADediting_870771(3545047, -), ADediting_870772(3545048, -), ADediting_870773(3545056, -), ADediting_870774(3547015, -), ADediting_870775(3547040, -), ADediting_870776(3547612, -), ADediting_870777(3553065, -), ADediting_870778(3556005, -), ADediting_870779(3556008, -), ADediting_870780(3556050, -), ADediting_870781(3556062, -), ADediting_870782(3556130, -), ADediting_1637267(3543845, -), ADediting_1637268(3556462, -), |
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RNA editing positional annotations for RNASEH1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_870745 | chr2_3541896_- | UTR3 |
| ADediting_870746 | chr2_3541908_- | UTR3 |
| ADediting_870747 | chr2_3541909_- | UTR3 |
| ADediting_870748 | chr2_3541910_- | UTR3 |
| ADediting_870749 | chr2_3541931_- | UTR3 |
| ADediting_870750 | chr2_3541935_- | UTR3 |
| ADediting_870751 | chr2_3541936_- | UTR3 |
| ADediting_870752 | chr2_3541948_- | UTR3 |
| ADediting_870753 | chr2_3541949_- | UTR3 |
| ADediting_870754 | chr2_3541950_- | UTR3 |
| ADediting_870755 | chr2_3541961_- | UTR3 |
| ADediting_870756 | chr2_3541981_- | UTR3 |
| ADediting_870757 | chr2_3541987_- | UTR3 |
| ADediting_870758 | chr2_3543841_- | UTR3 |
| ADediting_870759 | chr2_3543851_- | UTR3 |
| ADediting_870760 | chr2_3543878_- | UTR3 |
| ADediting_870761 | chr2_3543886_- | UTR3 |
| ADediting_870762 | chr2_3543887_- | UTR3 |
| ADediting_870763 | chr2_3544842_- | UTR3 |
| ADediting_870764 | chr2_3544877_- | UTR3 |
| ADediting_870765 | chr2_3544896_- | UTR3 |
| ADediting_870766 | chr2_3544913_- | UTR3 |
| ADediting_870767 | chr2_3545012_- | UTR3 |
| ADediting_870768 | chr2_3545017_- | UTR3 |
| ADediting_870769 | chr2_3545025_- | UTR3 |
| ADediting_870770 | chr2_3545026_- | UTR3 |
| ADediting_870771 | chr2_3545047_- | UTR3 |
| ADediting_870772 | chr2_3545048_- | UTR3 |
| ADediting_870773 | chr2_3545056_- | UTR3 |
| ADediting_870774 | chr2_3547015_- | intronic |
| ADediting_870775 | chr2_3547040_- | intronic |
| ADediting_870776 | chr2_3547612_- | intronic |
| ADediting_870777 | chr2_3553065_- | intronic |
| ADediting_870778 | chr2_3556005_- | intronic |
| ADediting_870779 | chr2_3556008_- | intronic |
| ADediting_870780 | chr2_3556050_- | intronic |
| ADediting_870781 | chr2_3556062_- | intronic |
| ADediting_870782 | chr2_3556130_- | intronic |
| ADediting_1637267 | chr2_3543845_- | UTR3 |
| ADediting_1637268 | chr2_3556462_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_870745 | chr2_3541896_- | SINE | Alu | Name=AluJo |
| ADediting_870746 | chr2_3541908_- | SINE | Alu | Name=AluJo |
| ADediting_870747 | chr2_3541909_- | SINE | Alu | Name=AluJo |
| ADediting_870748 | chr2_3541910_- | SINE | Alu | Name=AluJo |
| ADediting_870749 | chr2_3541931_- | SINE | Alu | Name=AluJo |
| ADediting_870750 | chr2_3541935_- | SINE | Alu | Name=AluJo |
| ADediting_870751 | chr2_3541936_- | SINE | Alu | Name=AluJo |
| ADediting_870752 | chr2_3541948_- | SINE | Alu | Name=AluJo |
| ADediting_870753 | chr2_3541949_- | SINE | Alu | Name=AluJo |
| ADediting_870754 | chr2_3541950_- | SINE | Alu | Name=AluJo |
| ADediting_870755 | chr2_3541961_- | SINE | Alu | Name=AluJo |
| ADediting_870756 | chr2_3541981_- | SINE | Alu | Name=AluJo |
| ADediting_870757 | chr2_3541987_- | SINE | Alu | Name=AluJo |
| ADediting_870758 | chr2_3543841_- | SINE | Alu | Name=AluJb |
| ADediting_870759 | chr2_3543851_- | SINE | Alu | Name=AluJb |
| ADediting_870760 | chr2_3543878_- | SINE | Alu | Name=AluJb |
| ADediting_870761 | chr2_3543886_- | SINE | Alu | Name=AluJb |
| ADediting_870762 | chr2_3543887_- | SINE | Alu | Name=AluJb |
| ADediting_870763 | chr2_3544842_- | SINE | Alu | Name=AluSz6 |
| ADediting_870764 | chr2_3544877_- | SINE | Alu | Name=AluSz6 |
| ADediting_870765 | chr2_3544896_- | SINE | Alu | Name=AluSz6 |
| ADediting_870766 | chr2_3544913_- | SINE | Alu | Name=AluSz6 |
| ADediting_870767 | chr2_3545012_- | SINE | Alu | Name=AluSz6 |
| ADediting_870768 | chr2_3545017_- | SINE | Alu | Name=AluSz6 |
| ADediting_870769 | chr2_3545025_- | SINE | Alu | Name=AluSz6 |
| ADediting_870770 | chr2_3545026_- | SINE | Alu | Name=AluSz6 |
| ADediting_870771 | chr2_3545047_- | SINE | Alu | Name=AluSz6 |
| ADediting_870772 | chr2_3545048_- | SINE | Alu | Name=AluSz6 |
| ADediting_870773 | chr2_3545056_- | SINE | Alu | Name=AluSz6 |
| ADediting_870774 | chr2_3547015_- | SINE | Alu | Name=AluSz6 |
| ADediting_870775 | chr2_3547040_- | SINE | Alu | Name=AluSz6 |
| ADediting_870776 | chr2_3547612_- | SINE | Alu | Name=AluSx4 |
| ADediting_870777 | chr2_3553065_- | SINE | Alu | Name=AluSx1 |
| ADediting_870778 | chr2_3556005_- | SINE | Alu | Name=AluSz |
| ADediting_870779 | chr2_3556008_- | SINE | Alu | Name=AluSz |
| ADediting_870780 | chr2_3556050_- | SINE | Alu | Name=AluSz |
| ADediting_870781 | chr2_3556062_- | SINE | Alu | Name=AluSz |
| ADediting_870782 | chr2_3556130_- | SINE | Alu | Name=AluSz |
| ADediting_1637267 | chr2_3543845_- | SINE | Alu | Name=AluJb |
| ADediting_1637268 | chr2_3556462_- | SINE | Alu | Name=AluSx |
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RNA A-to-I editing events in the alternative splicing sites for RNASEH1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RNASEH1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for RNASEH1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for RNASEH1 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1637267 | chr2_3543845_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-10400-3p | chr2 | 3543841 | 3543847 | 7mer-m8 | 3543840 | 3543861 | 140 | -20.37 |
| ADediting_1637267 | chr2_3543845_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-4437 | chr2 | 3543841 | 3543848 | 8mer-1a | 3543841 | 3543861 | 142 | -17.97 |
| ADediting_1637267 | chr2_3543845_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-4674 | chr2 | 3543841 | 3543847 | 7mer-m8 | 3543840 | 3543860 | 143 | -20.51 |
| ADediting_1637267 | chr2_3543845_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-6847-3p | chr2 | 3543844 | 3543850 | 7mer-m8 | 3543843 | 3543861 | 160 | -27.82 |
| ADediting_870746 | chr2_3541908_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-3189-3p | chr2 | 3541907 | 3541913 | 7mer-m8 | 3541906 | 3541928 | 145 | -19.15 |
| ADediting_870746 | chr2_3541908_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-6813-3p | chr2 | 3541906 | 3541912 | 7mer-m8 | 3541905 | 3541925 | 140 | -11.79 |
| ADediting_870747 | chr2_3541909_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-3192-5p | chr2 | 3541908 | 3541915 | 8mer-1a | 3541908 | 3541930 | 157 | -25.25 |
| ADediting_870747 | chr2_3541909_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-326 | chr2 | 3541907 | 3541913 | 7mer-m8 | 3541906 | 3541925 | 140 | -14.14 |
| ADediting_870747 | chr2_3541909_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-330-5p | chr2 | 3541907 | 3541913 | 7mer-m8 | 3541906 | 3541927 | 140 | -20.82 |
| ADediting_870747 | chr2_3541909_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-4314 | chr2 | 3541908 | 3541914 | 7mer-m8 | 3541907 | 3541924 | 140 | -18.87 |
| ADediting_870747 | chr2_3541909_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-514a-5p | chr2 | 3541906 | 3541912 | 7mer-m8 | 3541905 | 3541925 | 154 | -19.31 |
| ADediting_870748 | chr2_3541910_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-6771-5p | chr2 | 3541908 | 3541915 | 8mer-1a | 3541908 | 3541929 | 160 | -27.98 |
| ADediting_870749 | chr2_3541931_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-4751 | chr2 | 3541926 | 3541932 | 7mer-m8 | 3541925 | 3541948 | 158 | -22.8 |
| ADediting_870750 | chr2_3541935_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-4649-3p | chr2 | 3541935 | 3541941 | 7mer-m8 | 3541934 | 3541954 | 147 | -18.42 |
| ADediting_870750 | chr2_3541935_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-544b | chr2 | 3541934 | 3541940 | 7mer-m8 | 3541933 | 3541954 | 154 | -16.95 |
| ADediting_870750 | chr2_3541935_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-6078 | chr2 | 3541931 | 3541938 | 8mer-1a | 3541931 | 3541950 | 156 | -22.4 |
| ADediting_870752 | chr2_3541948_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-27b-5p | chr2 | 3541945 | 3541951 | 7mer-m8 | 3541944 | 3541963 | 147 | -14 |
| ADediting_870752 | chr2_3541948_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-28-5p | chr2 | 3541943 | 3541949 | 7mer-m8 | 3541942 | 3541962 | 151 | -18.76 |
| ADediting_870752 | chr2_3541948_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-3139 | chr2 | 3541943 | 3541949 | 7mer-m8 | 3541942 | 3541964 | 165 | -23.25 |
| ADediting_870752 | chr2_3541948_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-4720-3p | chr2 | 3541947 | 3541953 | 7mer-m8 | 3541946 | 3541966 | 140 | -11.81 |
| ADediting_870752 | chr2_3541948_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-708-5p | chr2 | 3541943 | 3541949 | 7mer-m8 | 3541942 | 3541963 | 162 | -24.03 |
| ADediting_870753 | chr2_3541949_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-4294 | chr2 | 3541944 | 3541950 | 7mer-m8 | 3541943 | 3541960 | 150 | -18.75 |
| ADediting_870755 | chr2_3541961_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-3940-3p | chr2 | 3541957 | 3541963 | 7mer-m8 | 3541956 | 3541979 | 146 | -22.56 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-518a-3p | chr2 | 3543874 | 3543880 | 7mer-m8 | 3543873 | 3543894 | 145 | -17.15 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-518b | chr2 | 3543874 | 3543880 | 7mer-m8 | 3543873 | 3543893 | 146 | -21.79 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-518c-3p | chr2 | 3543874 | 3543880 | 7mer-m8 | 3543873 | 3543894 | 146 | -18.08 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-518d-3p | chr2 | 3543874 | 3543880 | 7mer-m8 | 3543873 | 3543893 | 145 | -17.84 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-518e-3p | chr2 | 3543875 | 3543881 | 7mer-m8 | 3543874 | 3543895 | 144 | -14.43 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-518f-3p | chr2 | 3543874 | 3543880 | 7mer-m8 | 3543873 | 3543893 | 145 | -17.48 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-526a-3p | chr2 | 3543874 | 3543880 | 7mer-m8 | 3543873 | 3543893 | 146 | -17.71 |
| ADediting_870761 | chr2_3543886_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-8052 | chr2 | 3543881 | 3543887 | 7mer-1a | 3543881 | 3543899 | 144 | -25.62 |
| ADediting_870762 | chr2_3543887_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-513a-5p | chr2 | 3543886 | 3543892 | 7mer-m8 | 3543885 | 3543902 | 144 | -13.46 |
| ADediting_870762 | chr2_3543887_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-638 | chr2 | 3543881 | 3543887 | 7mer-1a | 3543881 | 3543905 | 155 | -33.45 |
| ADediting_870763 | chr2_3544842_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-149-5p | chr2 | 3544842 | 3544848 | 7mer-m8 | 3544841 | 3544863 | 152 | -22.11 |
| ADediting_870765 | chr2_3544896_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-3943 | chr2 | 3544892 | 3544898 | 7mer-m8 | 3544891 | 3544911 | 146 | -22.28 |
| ADediting_870769 | chr2_3545025_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-3176 | chr2 | 3545025 | 3545031 | 7mer-m8 | 3545024 | 3545042 | 140 | -15.24 |
| ADediting_870769 | chr2_3545025_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-3922-3p | chr2 | 3545025 | 3545031 | 7mer-m8 | 3545024 | 3545045 | 141 | -17.02 |
| ADediting_870771 | chr2_3545047_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-3117-3p | chr2 | 3545042 | 3545048 | 7mer-m8 | 3545041 | 3545061 | 154 | -16.21 |
| ADediting_870771 | chr2_3545047_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-4759 | chr2 | 3545042 | 3545049 | 8mer-1a | 3545042 | 3545064 | 147 | -14.7 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_870747 | chr2_3541909_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-887-5p | chr2 | 3541908 | 3541915 | 8mer-1a | 3541908 | 3541928 | 147 | -15.69 |
| ADediting_870748 | chr2_3541910_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-30b-3p | chr2 | 3541909 | 3541916 | 8mer-1a | 3541909 | 3541930 | 146 | -15.61 |
| ADediting_870748 | chr2_3541910_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-3689a-3p | chr2 | 3541909 | 3541916 | 8mer-1a | 3541909 | 3541930 | 141 | -15.75 |
| ADediting_870748 | chr2_3541910_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-3689b-3p | chr2 | 3541909 | 3541916 | 8mer-1a | 3541909 | 3541930 | 141 | -15.37 |
| ADediting_870748 | chr2_3541910_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-3689c | chr2 | 3541909 | 3541916 | 8mer-1a | 3541909 | 3541930 | 141 | -15.37 |
| ADediting_870748 | chr2_3541910_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-6779-5p | chr2 | 3541909 | 3541916 | 8mer-1a | 3541909 | 3541928 | 141 | -19.92 |
| ADediting_870748 | chr2_3541910_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-887-5p | chr2 | 3541908 | 3541915 | 8mer-1a | 3541908 | 3541928 | 147 | -15.69 |
| ADediting_870750 | chr2_3541935_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-1304-5p | chr2 | 3541935 | 3541941 | 7mer-m8 | 3541934 | 3541958 | 153 | -19.81 |
| ADediting_870751 | chr2_3541936_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-1304-5p | chr2 | 3541935 | 3541941 | 7mer-m8 | 3541934 | 3541958 | 153 | -19.81 |
| ADediting_870755 | chr2_3541961_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-3187-5p | chr2 | 3541960 | 3541966 | 7mer-m8 | 3541959 | 3541982 | 155 | -29.5 |
| ADediting_870755 | chr2_3541961_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-612 | chr2 | 3541960 | 3541966 | 7mer-m8 | 3541959 | 3541982 | 149 | -22.92 |
| ADediting_870755 | chr2_3541961_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-661 | chr2 | 3541958 | 3541964 | 7mer-m8 | 3541957 | 3541980 | 141 | -17.71 |
| ADediting_870755 | chr2_3541961_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-939-3p | chr2 | 3541959 | 3541965 | 7mer-m8 | 3541958 | 3541978 | 140 | -16.02 |
| ADediting_870756 | chr2_3541981_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-1208 | chr2 | 3541978 | 3541984 | 7mer-m8 | 3541977 | 3541996 | 145 | -13.13 |
| ADediting_870758 | chr2_3543841_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-1343-3p | chr2 | 3543838 | 3543844 | 7mer-m8 | 3543837 | 3543858 | 140 | -20.93 |
| ADediting_870758 | chr2_3543841_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-6742-3p | chr2 | 3543838 | 3543845 | 8mer-1a | 3543838 | 3543857 | 145 | -17.41 |
| ADediting_870758 | chr2_3543841_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-6783-3p | chr2 | 3543838 | 3543844 | 7mer-m8 | 3543837 | 3543857 | 146 | -19.15 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-302a-3p | chr2 | 3543875 | 3543881 | 7mer-m8 | 3543874 | 3543895 | 143 | -11.02 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-302b-3p | chr2 | 3543875 | 3543881 | 7mer-m8 | 3543874 | 3543896 | 141 | -9.54 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-302c-3p | chr2 | 3543875 | 3543881 | 7mer-m8 | 3543874 | 3543894 | 145 | -11.96 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-302d-3p | chr2 | 3543875 | 3543881 | 7mer-m8 | 3543874 | 3543901 | 143 | -10.53 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-302e | chr2 | 3543875 | 3543881 | 7mer-m8 | 3543874 | 3543890 | 141 | -8.62 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-372-3p | chr2 | 3543875 | 3543881 | 7mer-m8 | 3543874 | 3543894 | 153 | -16.03 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-512-3p | chr2 | 3543876 | 3543882 | 7mer-m8 | 3543875 | 3543896 | 149 | -15 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-519d-3p | chr2 | 3543874 | 3543880 | 7mer-m8 | 3543873 | 3543893 | 146 | -14.53 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-520a-3p | chr2 | 3543875 | 3543881 | 7mer-m8 | 3543874 | 3543895 | 140 | -11.03 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-520b-3p | chr2 | 3543875 | 3543881 | 7mer-m8 | 3543874 | 3543893 | 141 | -16.52 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-520c-3p | chr2 | 3543875 | 3543881 | 7mer-m8 | 3543874 | 3543894 | 146 | -16.52 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-520d-3p | chr2 | 3543875 | 3543881 | 7mer-m8 | 3543874 | 3543895 | 140 | -13.09 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-520e-3p | chr2 | 3543875 | 3543881 | 7mer-m8 | 3543874 | 3543894 | 140 | -13.32 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-520g-3p | chr2 | 3543873 | 3543879 | 7mer-m8 | 3543872 | 3543894 | 151 | -15.87 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-520h | chr2 | 3543873 | 3543879 | 7mer-m8 | 3543872 | 3543893 | 150 | -15.08 |
| ADediting_870760 | chr2_3543878_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-526b-3p | chr2 | 3543874 | 3543880 | 7mer-m8 | 3543873 | 3543893 | 146 | -16.66 |
| ADediting_870761 | chr2_3543886_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-10399-5p | chr2 | 3543885 | 3543891 | 7mer-m8 | 3543884 | 3543901 | 143 | -6.67 |
| ADediting_870761 | chr2_3543886_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-5089-5p | chr2 | 3543881 | 3543887 | 7mer-m8 | 3543880 | 3543901 | 146 | -11.97 |
| ADediting_870761 | chr2_3543886_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-6504-3p | chr2 | 3543885 | 3543891 | 7mer-m8 | 3543884 | 3543905 | 148 | -10.68 |
| ADediting_870762 | chr2_3543887_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-10399-5p | chr2 | 3543885 | 3543891 | 7mer-m8 | 3543884 | 3543901 | 143 | -6.67 |
| ADediting_870762 | chr2_3543887_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-6504-3p | chr2 | 3543885 | 3543891 | 7mer-m8 | 3543884 | 3543905 | 148 | -10.68 |
| ADediting_870762 | chr2_3543887_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-7151-3p | chr2 | 3543886 | 3543893 | 8mer-1a | 3543886 | 3543907 | 142 | -14.25 |
| ADediting_870764 | chr2_3544877_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-8062 | chr2 | 3544875 | 3544881 | 7mer-m8 | 3544874 | 3544896 | 144 | -10.32 |
| ADediting_870765 | chr2_3544896_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-150-5p | chr2 | 3544895 | 3544901 | 7mer-m8 | 3544894 | 3544917 | 142 | -15.65 |
| ADediting_870765 | chr2_3544896_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-6778-3p | chr2 | 3544893 | 3544899 | 7mer-m8 | 3544892 | 3544912 | 140 | -14.56 |
| ADediting_870767 | chr2_3545012_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-1245a | chr2 | 3545010 | 3545016 | 7mer-m8 | 3545009 | 3545029 | 153 | -18.22 |
| ADediting_870767 | chr2_3545012_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-8079 | chr2 | 3545010 | 3545016 | 7mer-m8 | 3545009 | 3545027 | 151 | -17.19 |
| ADediting_870770 | chr2_3545026_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-6878-3p | chr2 | 3545025 | 3545032 | 8mer-1a | 3545025 | 3545045 | 142 | -17.1 |
| ADediting_870771 | chr2_3545047_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-10399-5p | chr2 | 3545046 | 3545052 | 7mer-m8 | 3545045 | 3545066 | 148 | -11.84 |
| ADediting_870772 | chr2_3545048_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-10399-5p | chr2 | 3545046 | 3545052 | 7mer-m8 | 3545045 | 3545066 | 148 | -11.84 |
| ADediting_870773 | chr2_3545056_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-6807-5p | chr2 | 3545056 | 3545062 | 7mer-m8 | 3545055 | 3545076 | 147 | -21.32 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-5688 | chr2 | 3544377 | 3544383 | 7mer-m8 | 3544376 | 3544397 | 148 | -12.6 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-337-3p | chr2 | 3544713 | 3544720 | 8mer-1a | 3544713 | 3544734 | 152 | -14.35 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-4775 | chr2 | 3543775 | 3543781 | 7mer-m8 | 3543774 | 3543795 | 149 | -6.9 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-4775 | chr2 | 3545456 | 3545462 | 7mer-1a | 3545456 | 3545477 | 142 | -11.71 |
| ADediting_98288 | chr1_32086990_+ | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-5585-3p | chr2 | 3541591 | 3541597 | 7mer-m8 | 3541590 | 3541611 | 146 | -17.64 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_107020 | chr1_37500952_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-5581-3p | chr2 | 3541526 | 3541532 | 7mer-m8 | 3541525 | 3541547 | 150 | -12.66 |
| ADediting_107020 | chr1_37500952_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-5581-3p | chr2 | 3542719 | 3542726 | 8mer-1a | 3542719 | 3542740 | 145 | -19.48 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-151a-3p | chr2 | 3542536 | 3542542 | 7mer-m8 | 3542535 | 3542558 | 142 | -13.36 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-337-3p | chr2 | 3544032 | 3544039 | 8mer-1a | 3544032 | 3544053 | 155 | -16.02 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-381-3p | chr2 | 3545358 | 3545365 | 8mer-1a | 3545358 | 3545380 | 152 | -13.3 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-381-3p | chr2 | 3545358 | 3545365 | 8mer-1a | 3545358 | 3545380 | 152 | -13.3 |
| ADediting_291761 | chr11_93733708_- | ENSG00000171865.10 | ENST00000315212.4 | RNASEH1-201 | hsa-miR-1304-3p | chr2 | 3543529 | 3543536 | 8mer-1a | 3543529 | 3543550 | 140 | -18.26 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for RNASEH1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000315212.4 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_870745 | ENST00000315212.4 | chr2_3541896_- | 4823 | -1723.72 | -1723.72 | -1734.42 |
| ADediting_870746 | ENST00000315212.4 | chr2_3541908_- | 4811 | -1723.42 | -1723.72 | -1734.42 |
| ADediting_870747 | ENST00000315212.4 | chr2_3541909_- | 4810 | -1723.82 | -1723.72 | -1734.42 |
| ADediting_870748 | ENST00000315212.4 | chr2_3541910_- | 4809 | -1723.42 | -1723.72 | -1734.42 |
| ADediting_870749 | ENST00000315212.4 | chr2_3541931_- | 4788 | -1723.12 | -1723.72 | -1734.42 |
| ADediting_870750 | ENST00000315212.4 | chr2_3541935_- | 4784 | -1723.72 | -1723.72 | -1734.42 |
| ADediting_870751 | ENST00000315212.4 | chr2_3541936_- | 4783 | -1723.62 | -1723.72 | -1734.42 |
| ADediting_870752 | ENST00000315212.4 | chr2_3541948_- | 4771 | -1723.72 | -1723.72 | -1734.42 |
| ADediting_870753 | ENST00000315212.4 | chr2_3541949_- | 4770 | -1723.82 | -1723.72 | -1734.42 |
| ADediting_870754 | ENST00000315212.4 | chr2_3541950_- | 4769 | -1722.82 | -1723.72 | -1734.42 |
| ADediting_870755 | ENST00000315212.4 | chr2_3541961_- | 4758 | -1723.02 | -1723.72 | -1734.42 |
| ADediting_870756 | ENST00000315212.4 | chr2_3541981_- | 4738 | -1725.52 | -1723.72 | -1734.42 |
| ADediting_870757 | ENST00000315212.4 | chr2_3541987_- | 4732 | -1724.12 | -1723.72 | -1734.42 |
| ADediting_870758 | ENST00000315212.4 | chr2_3543841_- | 2878 | -1723.02 | -1723.72 | -1734.42 |
| ADediting_1637267 | ENST00000315212.4 | chr2_3543845_- | 2874 | -1727.02 | -1723.72 | -1734.42 |
| ADediting_870759 | ENST00000315212.4 | chr2_3543851_- | 2868 | -1729.12 | -1723.72 | -1734.42 |
| ADediting_870760 | ENST00000315212.4 | chr2_3543878_- | 2841 | -1723.32 | -1723.72 | -1734.42 |
| ADediting_870761 | ENST00000315212.4 | chr2_3543886_- | 2833 | -1723.72 | -1723.72 | -1734.42 |
| ADediting_870762 | ENST00000315212.4 | chr2_3543887_- | 2832 | -1723.82 | -1723.72 | -1734.42 |
| ADediting_870763 | ENST00000315212.4 | chr2_3544842_- | 1877 | -1723.92 | -1723.72 | -1734.42 |
| ADediting_870764 | ENST00000315212.4 | chr2_3544877_- | 1842 | -1726.22 | -1723.72 | -1734.42 |
| ADediting_870765 | ENST00000315212.4 | chr2_3544896_- | 1823 | -1723.82 | -1723.72 | -1734.42 |
| ADediting_870766 | ENST00000315212.4 | chr2_3544913_- | 1806 | -1723.90 | -1723.72 | -1734.42 |
| ADediting_870767 | ENST00000315212.4 | chr2_3545012_- | 1707 | -1725.30 | -1723.72 | -1734.42 |
| ADediting_870768 | ENST00000315212.4 | chr2_3545017_- | 1702 | -1724.30 | -1723.72 | -1734.42 |
| ADediting_870769 | ENST00000315212.4 | chr2_3545025_- | 1694 | -1723.42 | -1723.72 | -1734.42 |
| ADediting_870770 | ENST00000315212.4 | chr2_3545026_- | 1693 | -1723.42 | -1723.72 | -1734.42 |
| ADediting_870771 | ENST00000315212.4 | chr2_3545047_- | 1672 | -1722.82 | -1723.72 | -1734.42 |
| ADediting_870772 | ENST00000315212.4 | chr2_3545048_- | 1671 | -1724.02 | -1723.72 | -1734.42 |
| ADediting_870773 | ENST00000315212.4 | chr2_3545056_- | 1663 | -1723.32 | -1723.72 | -1734.42 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for RNASEH1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.06890944959122e-60 | 0.764541915529741 | 7.33301027201838e-61 | 0.765204195947685 | 1.97627269034442e-11 | 0.368941899071425 |
| AC | 2.17411375609213e-104 | 0.922311791635119 | 1.27141843788672e-83 | 0.883438820693684 | 7.19029472060062e-08 | 0.332582548313649 |
| PCC | 1.4679012354196e-54 | 0.850216172736275 | 1.45288627212708e-52 | 0.842074049568075 | 0.0312768730454081 | 0.155893497027547 |
| CER | 1.12065616654279e-24 | 0.713979307072072 | 5.17792300185598e-10 | 0.479880372864029 | 0.792620002122654 | 0.0216450616020199 |
| TCX | 2.74640499746396e-40 | 0.835321736281309 | 6.64905315045708e-21 | 0.670187888239832 | 0.40349120506197 | 0.0687044134138047 |
| FP | 6.0253315127886e-28 | 0.70392131049818 | 2.70263628533287e-27 | 0.697765960432904 | 0.137285208107155 | 0.111816880074231 |
| IFG | 1.06507322481552e-05 | 0.759568790212158 | 0.000901393787379703 | 0.622004807591962 | 0.662337049600122 | -0.091855365131772 |
| PG | 3.31501046033957e-65 | 0.891567449531709 | 2.72784225200662e-40 | 0.786045042498111 | 0.58938745535396 | -0.0398272569899291 |
| STG | 4.54373346163526e-27 | 0.871262132406805 | 3.63352411771162e-15 | 0.729313156375974 | 0.223581484749244 | 0.134201307303096 |
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Relation with AD stages for RNASEH1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for RNASEH1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNASEH1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| RNASEH1 | C4225312 | PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS, AUTOSOMAL RECESSIVE 2 | 1 | CTD_human;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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