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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for LEPROTL1 |
 Gene summary |
| Gene information | Gene symbol | LEPROTL1 | Gene ID | 23484 |
| Gene name | leptin receptor overlapping transcript like 1 | |
| Synonyms | HSPC112|Vps55|my047 | |
| Cytomap | 8p12 | |
| Type of gene | protein-coding | |
| Description | leptin receptor overlapping transcript-like 1endospanin-2 | |
| Modification date | 20200313 | |
| UniProtAcc | O95214, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for LEPROTL1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_1401167(30097461, +), ADediting_1401168(30097495, +), ADediting_1401169(30097511, +), ADediting_1401170(30097515, +), ADediting_1401171(30097553, +), ADediting_1401172(30099336, +), ADediting_1401173(30099406, +), ADediting_1401174(30099415, +), ADediting_1401175(30099416, +), ADediting_1401176(30099458, +), ADediting_1401177(30099523, +), ADediting_1401178(30100469, +), ADediting_1401179(30100501, +), ADediting_1401180(30100507, +), ADediting_1401181(30100518, +), ADediting_1401182(30100530, +), ADediting_1401183(30100534, +), ADediting_1401184(30100549, +), ADediting_1401185(30100550, +), ADediting_1401186(30100553, +), ADediting_1401187(30100554, +), ADediting_1401188(30100567, +), ADediting_1401189(30100575, +), ADediting_1401190(30100579, +), ADediting_1401191(30100589, +), ADediting_1401192(30100634, +), ADediting_1401193(30100641, +), ADediting_1401194(30100651, +), ADediting_1401195(30100653, +), ADediting_1401196(30100671, +), ADediting_1401197(30100710, +), ADediting_1401198(30100711, +), ADediting_1401199(30100723, +), ADediting_1401200(30101484, +), ADediting_1401201(30101520, +), ADediting_1401202(30101523, +), ADediting_1401203(30101533, +), ADediting_1401204(30101546, +), ADediting_1401205(30101547, +), ADediting_1401206(30101552, +), ADediting_1401207(30101561, +), ADediting_1401208(30101583, +), ADediting_1401209(30101588, +), ADediting_1401210(30101589, +), ADediting_1401211(30104921, +), ADediting_1401212(30104976, +), ADediting_1401213(30108721, +), ADediting_1401214(30108728, +), ADediting_1401215(30108740, +), ADediting_1401216(30108745, +), ADediting_1401217(30108767, +), ADediting_1401218(30108848, +), ADediting_1401219(30108939, +), ADediting_1401220(30108965, +), ADediting_1401221(30108985, +), ADediting_1401222(30110525, +), ADediting_1401223(30110526, +), ADediting_1401224(30110552, +), ADediting_1401225(30110558, +), ADediting_1401226(30110573, +), ADediting_1401227(30110583, +), ADediting_1401228(30110613, +), ADediting_1401229(30110623, +), ADediting_1401230(30110630, +), ADediting_1401231(30113173, +), ADediting_1401232(30113208, +), ADediting_1401233(30113220, +), ADediting_1401234(30113221, +), ADediting_1401235(30114344, +), ADediting_1401236(30114377, +), ADediting_1401237(30114390, +), ADediting_1401238(30114394, +), ADediting_1401239(30114408, +), ADediting_1401240(30118086, +), ADediting_1401241(30118089, +), ADediting_1401242(30118125, +), ADediting_1401243(30118164, +), ADediting_1401244(30118244, +), ADediting_1401245(30118249, +), ADediting_1401246(30118250, +), ADediting_1401247(30118289, +), ADediting_1401248(30119854, +), ADediting_1401249(30119867, +), ADediting_1401250(30129601, +), ADediting_1401251(30129611, +), ADediting_1401252(30129626, +), ADediting_1401253(30165610, +), ADediting_1401254(30166838, +), ADediting_1401255(30166888, +), ADediting_1401256(30166895, +), ADediting_1401257(30166896, +), ADediting_1401258(30167185, +), ADediting_1401259(30167203, +), ADediting_1401260(30167211, +), ADediting_1401261(30167217, +), ADediting_1401262(30167245, +), ADediting_1401263(30167479, +), ADediting_1401264(30167890, +), ADediting_1401265(30169909, +), ADediting_1401266(30169917, +), ADediting_1401267(30169945, +), ADediting_1401268(30169964, +), ADediting_1401269(30169987, +), ADediting_1401270(30169997, +), ADediting_1401271(30170012, +), ADediting_1401272(30170026, +), ADediting_1401273(30170052, +), ADediting_1401274(30170062, +), ADediting_1401275(30170079, +), ADediting_1401276(30170673, +), ADediting_1401277(30170741, +), ADediting_1401278(30170840, +), ADediting_1401279(30170869, +), ADediting_1401280(30170870, +), ADediting_1401281(30170878, +), ADediting_1401282(30172537, +), ADediting_1401283(30172544, +), ADediting_1401284(30172551, +), ADediting_1401285(30172563, +), ADediting_1401286(30172585, +), ADediting_1401287(30172590, +), ADediting_1401288(30172592, +), ADediting_1401289(30172658, +), ADediting_1401290(30172673, +), ADediting_1401291(30172700, +), ADediting_1401292(30173512, +), ADediting_1401293(30173532, +), ADediting_1401294(30173539, +), ADediting_1401295(30173559, +), ADediting_1401296(30173583, +), ADediting_1401297(30173609, +), ADediting_1401298(30173623, +), ADediting_1401299(30173624, +), ADediting_1401300(30173636, +), ADediting_1401301(30173679, +), ADediting_1401302(30173685, +), ADediting_1401303(30173693, +), ADediting_1401304(30174386, +), ADediting_1401305(30174462, +), ADediting_1401306(30174472, +), ADediting_1590389(30108828, +), ADediting_1590390(30110548, +), ADediting_1590391(30110550, +), ADediting_1590392(30110572, +), ADediting_1590393(30110578, +), ADediting_1590394(30110580, +), ADediting_1669456(30173123, +), |
Top |
RNA editing positional annotations for LEPROTL1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_1401211 | chr8_30104921_+ | stoploss | ENST00000650149.1 | c.A467G | p.X156W | . | . | . |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1401167 | chr8_30097461_+ | intronic |
| ADediting_1401168 | chr8_30097495_+ | intronic |
| ADediting_1401169 | chr8_30097511_+ | intronic |
| ADediting_1401170 | chr8_30097515_+ | intronic |
| ADediting_1401171 | chr8_30097553_+ | intronic |
| ADediting_1401172 | chr8_30099336_+ | intronic |
| ADediting_1401173 | chr8_30099406_+ | intronic |
| ADediting_1401174 | chr8_30099415_+ | intronic |
| ADediting_1401175 | chr8_30099416_+ | intronic |
| ADediting_1401176 | chr8_30099458_+ | intronic |
| ADediting_1401177 | chr8_30099523_+ | intronic |
| ADediting_1401178 | chr8_30100469_+ | intronic |
| ADediting_1401179 | chr8_30100501_+ | intronic |
| ADediting_1401180 | chr8_30100507_+ | intronic |
| ADediting_1401181 | chr8_30100518_+ | intronic |
| ADediting_1401182 | chr8_30100530_+ | intronic |
| ADediting_1401183 | chr8_30100534_+ | intronic |
| ADediting_1401184 | chr8_30100549_+ | intronic |
| ADediting_1401185 | chr8_30100550_+ | intronic |
| ADediting_1401186 | chr8_30100553_+ | intronic |
| ADediting_1401187 | chr8_30100554_+ | intronic |
| ADediting_1401188 | chr8_30100567_+ | intronic |
| ADediting_1401189 | chr8_30100575_+ | intronic |
| ADediting_1401190 | chr8_30100579_+ | intronic |
| ADediting_1401191 | chr8_30100589_+ | intronic |
| ADediting_1401192 | chr8_30100634_+ | intronic |
| ADediting_1401193 | chr8_30100641_+ | intronic |
| ADediting_1401194 | chr8_30100651_+ | intronic |
| ADediting_1401195 | chr8_30100653_+ | intronic |
| ADediting_1401196 | chr8_30100671_+ | intronic |
| ADediting_1401197 | chr8_30100710_+ | intronic |
| ADediting_1401198 | chr8_30100711_+ | intronic |
| ADediting_1401199 | chr8_30100723_+ | intronic |
| ADediting_1401200 | chr8_30101484_+ | intronic |
| ADediting_1401201 | chr8_30101520_+ | intronic |
| ADediting_1401202 | chr8_30101523_+ | intronic |
| ADediting_1401203 | chr8_30101533_+ | intronic |
| ADediting_1401204 | chr8_30101546_+ | intronic |
| ADediting_1401205 | chr8_30101547_+ | intronic |
| ADediting_1401206 | chr8_30101552_+ | intronic |
| ADediting_1401207 | chr8_30101561_+ | intronic |
| ADediting_1401208 | chr8_30101583_+ | intronic |
| ADediting_1401209 | chr8_30101588_+ | intronic |
| ADediting_1401210 | chr8_30101589_+ | intronic |
| ADediting_1401211 | chr8_30104921_+ | exonic |
| ADediting_1401212 | chr8_30104976_+ | UTR3 |
| ADediting_1401213 | chr8_30108721_+ | intronic |
| ADediting_1401214 | chr8_30108728_+ | intronic |
| ADediting_1401215 | chr8_30108740_+ | intronic |
| ADediting_1401216 | chr8_30108745_+ | intronic |
| ADediting_1401217 | chr8_30108767_+ | intronic |
| ADediting_1401218 | chr8_30108848_+ | intronic |
| ADediting_1401219 | chr8_30108939_+ | intronic |
| ADediting_1401220 | chr8_30108965_+ | intronic |
| ADediting_1401221 | chr8_30108985_+ | intronic |
| ADediting_1401222 | chr8_30110525_+ | intronic |
| ADediting_1401223 | chr8_30110526_+ | intronic |
| ADediting_1401224 | chr8_30110552_+ | intronic |
| ADediting_1401225 | chr8_30110558_+ | intronic |
| ADediting_1401226 | chr8_30110573_+ | intronic |
| ADediting_1401227 | chr8_30110583_+ | intronic |
| ADediting_1401228 | chr8_30110613_+ | intronic |
| ADediting_1401229 | chr8_30110623_+ | intronic |
| ADediting_1401230 | chr8_30110630_+ | intronic |
| ADediting_1401231 | chr8_30113173_+ | intronic |
| ADediting_1401232 | chr8_30113208_+ | intronic |
| ADediting_1401233 | chr8_30113220_+ | intronic |
| ADediting_1401234 | chr8_30113221_+ | intronic |
| ADediting_1401235 | chr8_30114344_+ | intronic |
| ADediting_1401236 | chr8_30114377_+ | intronic |
| ADediting_1401237 | chr8_30114390_+ | intronic |
| ADediting_1401238 | chr8_30114394_+ | intronic |
| ADediting_1401239 | chr8_30114408_+ | intronic |
| ADediting_1401240 | chr8_30118086_+ | intronic |
| ADediting_1401241 | chr8_30118089_+ | intronic |
| ADediting_1401242 | chr8_30118125_+ | intronic |
| ADediting_1401243 | chr8_30118164_+ | intronic |
| ADediting_1401244 | chr8_30118244_+ | intronic |
| ADediting_1401245 | chr8_30118249_+ | intronic |
| ADediting_1401246 | chr8_30118250_+ | intronic |
| ADediting_1401247 | chr8_30118289_+ | intronic |
| ADediting_1401248 | chr8_30119854_+ | intronic |
| ADediting_1401249 | chr8_30119867_+ | intronic |
| ADediting_1401250 | chr8_30129601_+ | intronic |
| ADediting_1401251 | chr8_30129611_+ | intronic |
| ADediting_1401252 | chr8_30129626_+ | intronic |
| ADediting_1401253 | chr8_30165610_+ | intronic |
| ADediting_1401254 | chr8_30166838_+ | intronic |
| ADediting_1401255 | chr8_30166888_+ | intronic |
| ADediting_1401256 | chr8_30166895_+ | intronic |
| ADediting_1401257 | chr8_30166896_+ | intronic |
| ADediting_1401258 | chr8_30167185_+ | intronic |
| ADediting_1401259 | chr8_30167203_+ | intronic |
| ADediting_1401260 | chr8_30167211_+ | intronic |
| ADediting_1401261 | chr8_30167217_+ | intronic |
| ADediting_1401262 | chr8_30167245_+ | intronic |
| ADediting_1401263 | chr8_30167479_+ | intronic |
| ADediting_1401264 | chr8_30167890_+ | intronic |
| ADediting_1401265 | chr8_30169909_+ | intronic |
| ADediting_1401266 | chr8_30169917_+ | intronic |
| ADediting_1401267 | chr8_30169945_+ | intronic |
| ADediting_1401268 | chr8_30169964_+ | intronic |
| ADediting_1401269 | chr8_30169987_+ | intronic |
| ADediting_1401270 | chr8_30169997_+ | intronic |
| ADediting_1401271 | chr8_30170012_+ | intronic |
| ADediting_1401272 | chr8_30170026_+ | intronic |
| ADediting_1401273 | chr8_30170052_+ | intronic |
| ADediting_1401274 | chr8_30170062_+ | intronic |
| ADediting_1401275 | chr8_30170079_+ | intronic |
| ADediting_1401276 | chr8_30170673_+ | intronic |
| ADediting_1401277 | chr8_30170741_+ | intronic |
| ADediting_1401278 | chr8_30170840_+ | intronic |
| ADediting_1401279 | chr8_30170869_+ | intronic |
| ADediting_1401280 | chr8_30170870_+ | intronic |
| ADediting_1401281 | chr8_30170878_+ | intronic |
| ADediting_1401282 | chr8_30172537_+ | intronic |
| ADediting_1401283 | chr8_30172544_+ | intronic |
| ADediting_1401284 | chr8_30172551_+ | intronic |
| ADediting_1401285 | chr8_30172563_+ | intronic |
| ADediting_1401286 | chr8_30172585_+ | intronic |
| ADediting_1401287 | chr8_30172590_+ | intronic |
| ADediting_1401288 | chr8_30172592_+ | intronic |
| ADediting_1401289 | chr8_30172658_+ | intronic |
| ADediting_1401290 | chr8_30172673_+ | intronic |
| ADediting_1401291 | chr8_30172700_+ | intronic |
| ADediting_1401292 | chr8_30173512_+ | intronic |
| ADediting_1401293 | chr8_30173532_+ | intronic |
| ADediting_1401294 | chr8_30173539_+ | intronic |
| ADediting_1401295 | chr8_30173559_+ | intronic |
| ADediting_1401296 | chr8_30173583_+ | intronic |
| ADediting_1401297 | chr8_30173609_+ | intronic |
| ADediting_1401298 | chr8_30173623_+ | intronic |
| ADediting_1401299 | chr8_30173624_+ | intronic |
| ADediting_1401300 | chr8_30173636_+ | intronic |
| ADediting_1401301 | chr8_30173679_+ | intronic |
| ADediting_1401302 | chr8_30173685_+ | intronic |
| ADediting_1401303 | chr8_30173693_+ | intronic |
| ADediting_1401304 | chr8_30174386_+ | intronic |
| ADediting_1401305 | chr8_30174462_+ | intronic |
| ADediting_1401306 | chr8_30174472_+ | intronic |
| ADediting_1590389 | chr8_30108828_+ | intronic |
| ADediting_1590390 | chr8_30110548_+ | intronic |
| ADediting_1590391 | chr8_30110550_+ | intronic |
| ADediting_1590392 | chr8_30110572_+ | intronic |
| ADediting_1590393 | chr8_30110578_+ | intronic |
| ADediting_1590394 | chr8_30110580_+ | intronic |
| ADediting_1669456 | chr8_30173123_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1401167 | chr8_30097461_+ | SINE | Alu | Name=AluSg7 |
| ADediting_1401168 | chr8_30097495_+ | SINE | Alu | Name=AluSg7 |
| ADediting_1401169 | chr8_30097511_+ | SINE | Alu | Name=AluSg7 |
| ADediting_1401170 | chr8_30097515_+ | SINE | Alu | Name=AluSg7 |
| ADediting_1401171 | chr8_30097553_+ | SINE | Alu | Name=AluSg7 |
| ADediting_1401172 | chr8_30099336_+ | SINE | Alu | Name=AluSc |
| ADediting_1401173 | chr8_30099406_+ | SINE | Alu | Name=AluSc |
| ADediting_1401174 | chr8_30099415_+ | SINE | Alu | Name=AluSc |
| ADediting_1401175 | chr8_30099416_+ | SINE | Alu | Name=AluSc |
| ADediting_1401176 | chr8_30099458_+ | SINE | Alu | Name=AluSc |
| ADediting_1401177 | chr8_30099523_+ | SINE | Alu | Name=AluSc |
| ADediting_1401178 | chr8_30100469_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401179 | chr8_30100501_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401180 | chr8_30100507_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401181 | chr8_30100518_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401182 | chr8_30100530_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401183 | chr8_30100534_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401184 | chr8_30100549_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401185 | chr8_30100550_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401186 | chr8_30100553_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401187 | chr8_30100554_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401188 | chr8_30100567_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401189 | chr8_30100575_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401190 | chr8_30100579_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401191 | chr8_30100589_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401192 | chr8_30100634_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401193 | chr8_30100641_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401194 | chr8_30100651_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401195 | chr8_30100653_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401196 | chr8_30100671_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401197 | chr8_30100710_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401198 | chr8_30100711_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401199 | chr8_30100723_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1401200 | chr8_30101484_+ | SINE | Alu | Name=AluSp |
| ADediting_1401201 | chr8_30101520_+ | SINE | Alu | Name=AluSp |
| ADediting_1401202 | chr8_30101523_+ | SINE | Alu | Name=AluSp |
| ADediting_1401203 | chr8_30101533_+ | SINE | Alu | Name=AluSp |
| ADediting_1401204 | chr8_30101546_+ | SINE | Alu | Name=AluSp |
| ADediting_1401205 | chr8_30101547_+ | SINE | Alu | Name=AluSp |
| ADediting_1401206 | chr8_30101552_+ | SINE | Alu | Name=AluSp |
| ADediting_1401207 | chr8_30101561_+ | SINE | Alu | Name=AluSp |
| ADediting_1401208 | chr8_30101583_+ | SINE | Alu | Name=AluSp |
| ADediting_1401209 | chr8_30101588_+ | SINE | Alu | Name=AluSp |
| ADediting_1401210 | chr8_30101589_+ | SINE | Alu | Name=AluSp |
| ADediting_1401211 | chr8_30104921_+ | SINE | Alu | Name=AluY |
| ADediting_1401212 | chr8_30104976_+ | SINE | Alu | Name=AluY |
| ADediting_1401213 | chr8_30108721_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1401214 | chr8_30108728_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1401215 | chr8_30108740_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1401216 | chr8_30108745_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1401217 | chr8_30108767_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1401218 | chr8_30108848_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1401219 | chr8_30108939_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1401220 | chr8_30108965_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1401221 | chr8_30108985_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1401222 | chr8_30110525_+ | SINE | Alu | Name=AluSz |
| ADediting_1401223 | chr8_30110526_+ | SINE | Alu | Name=AluSz |
| ADediting_1401224 | chr8_30110552_+ | SINE | Alu | Name=AluSz |
| ADediting_1401225 | chr8_30110558_+ | SINE | Alu | Name=AluSz |
| ADediting_1401226 | chr8_30110573_+ | SINE | Alu | Name=AluSz |
| ADediting_1401227 | chr8_30110583_+ | SINE | Alu | Name=AluSz |
| ADediting_1401228 | chr8_30110613_+ | SINE | Alu | Name=AluSz |
| ADediting_1401229 | chr8_30110623_+ | SINE | Alu | Name=AluSz |
| ADediting_1401230 | chr8_30110630_+ | SINE | Alu | Name=AluSz |
| ADediting_1401231 | chr8_30113173_+ | SINE | Alu | Name=AluSz |
| ADediting_1401232 | chr8_30113208_+ | SINE | Alu | Name=AluSz |
| ADediting_1401233 | chr8_30113220_+ | SINE | Alu | Name=AluSz |
| ADediting_1401234 | chr8_30113221_+ | SINE | Alu | Name=AluSz |
| ADediting_1401235 | chr8_30114344_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401236 | chr8_30114377_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401237 | chr8_30114390_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401238 | chr8_30114394_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401239 | chr8_30114408_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401240 | chr8_30118086_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401241 | chr8_30118089_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401242 | chr8_30118125_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401243 | chr8_30118164_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401244 | chr8_30118244_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401245 | chr8_30118249_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401246 | chr8_30118250_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401247 | chr8_30118289_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401248 | chr8_30119854_+ | SINE | Alu | Name=AluSz |
| ADediting_1401249 | chr8_30119867_+ | SINE | Alu | Name=AluSz |
| ADediting_1401250 | chr8_30129601_+ | SINE | Alu | Name=AluSz |
| ADediting_1401251 | chr8_30129611_+ | SINE | Alu | Name=AluSz |
| ADediting_1401252 | chr8_30129626_+ | SINE | Alu | Name=AluSz |
| ADediting_1401253 | chr8_30165610_+ | SINE | Alu | Name=AluSp |
| ADediting_1401254 | chr8_30166838_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1401255 | chr8_30166888_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1401256 | chr8_30166895_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1401257 | chr8_30166896_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1401258 | chr8_30167185_+ | SINE | Alu | Name=AluJb |
| ADediting_1401259 | chr8_30167203_+ | SINE | Alu | Name=AluJb |
| ADediting_1401260 | chr8_30167211_+ | SINE | Alu | Name=AluJb |
| ADediting_1401261 | chr8_30167217_+ | SINE | Alu | Name=AluJb |
| ADediting_1401262 | chr8_30167245_+ | SINE | Alu | Name=AluJb |
| ADediting_1401263 | chr8_30167479_+ | SINE | Alu | Name=AluJr |
| ADediting_1401264 | chr8_30167890_+ | SINE | Alu | Name=AluSz |
| ADediting_1401265 | chr8_30169909_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401266 | chr8_30169917_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401267 | chr8_30169945_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401268 | chr8_30169964_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401269 | chr8_30169987_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401270 | chr8_30169997_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401271 | chr8_30170012_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401272 | chr8_30170026_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401273 | chr8_30170052_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401274 | chr8_30170062_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401275 | chr8_30170079_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401276 | chr8_30170673_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401277 | chr8_30170741_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401278 | chr8_30170840_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401279 | chr8_30170869_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401280 | chr8_30170870_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401281 | chr8_30170878_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1401282 | chr8_30172537_+ | SINE | Alu | Name=AluSz |
| ADediting_1401283 | chr8_30172544_+ | SINE | Alu | Name=AluSz |
| ADediting_1401284 | chr8_30172551_+ | SINE | Alu | Name=AluSz |
| ADediting_1401285 | chr8_30172563_+ | SINE | Alu | Name=AluSz |
| ADediting_1401286 | chr8_30172585_+ | SINE | Alu | Name=AluSz |
| ADediting_1401287 | chr8_30172590_+ | SINE | Alu | Name=AluSz |
| ADediting_1401288 | chr8_30172592_+ | SINE | Alu | Name=AluSz |
| ADediting_1401289 | chr8_30172658_+ | SINE | Alu | Name=AluSz |
| ADediting_1401290 | chr8_30172673_+ | SINE | Alu | Name=AluSz |
| ADediting_1401291 | chr8_30172700_+ | SINE | Alu | Name=AluSz |
| ADediting_1401292 | chr8_30173512_+ | SINE | Alu | Name=AluJr |
| ADediting_1401293 | chr8_30173532_+ | SINE | Alu | Name=AluJr |
| ADediting_1401294 | chr8_30173539_+ | SINE | Alu | Name=AluJr |
| ADediting_1401295 | chr8_30173559_+ | SINE | Alu | Name=AluJr |
| ADediting_1401296 | chr8_30173583_+ | SINE | Alu | Name=AluJr |
| ADediting_1401297 | chr8_30173609_+ | SINE | Alu | Name=AluJr |
| ADediting_1401298 | chr8_30173623_+ | SINE | Alu | Name=AluJr |
| ADediting_1401299 | chr8_30173624_+ | SINE | Alu | Name=AluJr |
| ADediting_1401300 | chr8_30173636_+ | SINE | Alu | Name=AluJr |
| ADediting_1401301 | chr8_30173679_+ | SINE | Alu | Name=AluJr |
| ADediting_1401302 | chr8_30173685_+ | SINE | Alu | Name=AluJr |
| ADediting_1401303 | chr8_30173693_+ | SINE | Alu | Name=AluJr |
| ADediting_1401304 | chr8_30174386_+ | SINE | Alu | Name=AluSz |
| ADediting_1401305 | chr8_30174462_+ | SINE | Alu | Name=AluSz |
| ADediting_1401306 | chr8_30174472_+ | SINE | Alu | Name=AluSz |
| ADediting_1590389 | chr8_30108828_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1590390 | chr8_30110548_+ | SINE | Alu | Name=AluSz |
| ADediting_1590391 | chr8_30110550_+ | SINE | Alu | Name=AluSz |
| ADediting_1590392 | chr8_30110572_+ | SINE | Alu | Name=AluSz |
| ADediting_1590393 | chr8_30110578_+ | SINE | Alu | Name=AluSz |
| ADediting_1590394 | chr8_30110580_+ | SINE | Alu | Name=AluSz |
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RNA A-to-I editing events in the alternative splicing sites for LEPROTL1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for LEPROTL1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for LEPROTL1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for LEPROTL1 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1401212 | chr8_30104976_+ | ENSG00000104660.19 | ENST00000519466.1 | LEPROTL1-205 | hsa-miR-3189-3p | chr8 | 30104970 | 30104976 | 7mer-m8 | 30104955 | 30104977 | 149 | -23.45 |
| ADediting_1401212 | chr8_30104976_+ | ENSG00000104660.19 | ENST00000519466.1 | LEPROTL1-205 | hsa-miR-6813-3p | chr8 | 30104971 | 30104977 | 7mer-m8 | 30104958 | 30104978 | 140 | -12.55 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000104660.19 | ENST00000523116.5 | LEPROTL1-208 | hsa-miR-5688 | chr8 | 30138268 | 30138274 | 7mer-m8 | 30138254 | 30138275 | 145 | -12.79 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000104660.19 | ENST00000442880.6 | LEPROTL1-202 | hsa-miR-589-3p | chr8 | 30137450 | 30137456 | 7mer-m8 | 30137436 | 30137457 | 148 | -26.23 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000104660.19 | ENST00000321250.13 | LEPROTL1-201 | hsa-miR-381-3p | chr8 | 30107107 | 30107114 | 8mer-1a | 30107095 | 30107114 | 149 | -15.93 |
| ADediting_286380 | chr11_79422188_- | ENSG00000104660.19 | ENST00000321250.13 | LEPROTL1-201 | hsa-miR-5579-3p | chr8 | 30107557 | 30107563 | 7mer-m8 | 30107541 | 30107564 | 151 | -14.57 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000104660.19 | ENST00000442880.6 | LEPROTL1-202 | hsa-miR-4775 | chr8 | 30137566 | 30137572 | 7mer-m8 | 30137553 | 30137573 | 158 | -9.3 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000104660.19 | ENST00000523116.5 | LEPROTL1-208 | hsa-miR-4775 | chr8 | 30137566 | 30137572 | 7mer-m8 | 30137553 | 30137573 | 158 | -9.3 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000104660.19 | ENST00000321250.13 | LEPROTL1-201 | hsa-miR-5585-3p | chr8 | 30105910 | 30105916 | 7mer-m8 | 30105894 | 30105917 | 158 | -20.37 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000104660.19 | ENST00000518001.1 | LEPROTL1-203 | hsa-miR-5585-3p | chr8 | 30105910 | 30105916 | 7mer-m8 | 30105894 | 30105917 | 158 | -20.37 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000104660.19 | ENST00000518192.5 | LEPROTL1-204 | hsa-miR-5585-3p | chr8 | 30105910 | 30105916 | 7mer-m8 | 30105894 | 30105917 | 158 | -20.37 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000104660.19 | ENST00000321250.13 | LEPROTL1-201 | hsa-miR-589-3p | chr8 | 30107795 | 30107801 | 7mer-m8 | 30107778 | 30107802 | 143 | -12.4 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000104660.19 | ENST00000321250.13 | LEPROTL1-201 | hsa-miR-589-3p | chr8 | 30108510 | 30108516 | 7mer-m8 | 30108496 | 30108517 | 141 | -11.89 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000104660.19 | ENST00000523116.5 | LEPROTL1-208 | hsa-miR-589-3p | chr8 | 30138049 | 30138056 | 8mer-1a | 30138033 | 30138056 | 140 | -11.28 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000104660.19 | ENST00000523116.5 | LEPROTL1-208 | hsa-miR-4477b | chr8 | 30138131 | 30138138 | 8mer-1a | 30138118 | 30138138 | 154 | -10.63 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000104660.19 | ENST00000523116.5 | LEPROTL1-208 | hsa-miR-4477b | chr8 | 30138131 | 30138138 | 8mer-1a | 30138118 | 30138138 | 154 | -10.63 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000104660.19 | ENST00000321250.13 | LEPROTL1-201 | hsa-miR-4775 | chr8 | 30106266 | 30106272 | 7mer-m8 | 30106252 | 30106273 | 140 | -2.94 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000104660.19 | ENST00000321250.13 | LEPROTL1-201 | hsa-miR-4775 | chr8 | 30106497 | 30106503 | 7mer-m8 | 30106483 | 30106504 | 146 | -7.43 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000104660.19 | ENST00000321250.13 | LEPROTL1-201 | hsa-miR-4775 | chr8 | 30107406 | 30107412 | 7mer-m8 | 30107393 | 30107413 | 152 | -5.31 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000104660.19 | ENST00000442880.6 | LEPROTL1-202 | hsa-miR-4775 | chr8 | 30137606 | 30137612 | 7mer-m8 | 30137591 | 30137613 | 145 | -5.55 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000104660.19 | ENST00000523116.5 | LEPROTL1-208 | hsa-miR-4775 | chr8 | 30137606 | 30137612 | 7mer-m8 | 30137591 | 30137613 | 145 | -5.55 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for LEPROTL1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000519466.1 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1401211 | ENST00000519466.1 | chr8_30104921_+ | 409 | -173.10 | -170.00 | -175.70 |
| ADediting_1401212 | ENST00000519466.1 | chr8_30104976_+ | 464 | -174.00 | -170.00 | -175.70 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for LEPROTL1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_1401172 | chr8_30099336_+ | 0.103370212959942 | -0.0926808462123697 | 0.00348975309524607 | -0.165422163343146 | 4.41427198324188e-09 | 0.325469753858408 |
| DLPFC | ADediting_1401181 | chr8_30100518_+ | 0.388791972854969 | 0.0491163992751246 | 0.463046701427977 | -0.0418300069423383 | 1.01343939002488e-08 | 0.318147735733009 |
| DLPFC | ADediting_1401184 | chr8_30100549_+ | 0.412405102787393 | 0.0467173461114989 | 0.149778260051635 | -0.0819978407148581 | 4.97592122171225e-09 | 0.324426577534331 |
| DLPFC | ADediting_1401189 | chr8_30100575_+ | 0.572550862537694 | -0.0321716808729883 | 0.0296801137996725 | -0.123519541844589 | 3.72008147718399e-12 | 0.381133851319919 |
| DLPFC | ADediting_1401195 | chr8_30100653_+ | 0.0880137525220781 | 0.0970557709237334 | 0.641450968691846 | -0.026550935110583 | 5.55885988213853e-10 | 0.342922268051402 |
| DLPFC | ADediting_1401196 | chr8_30100671_+ | 0.0840458424420568 | 0.0982848977747002 | 0.733324889207706 | 0.0194274586347475 | 2.16593734007751e-09 | 0.331591038085742 |
| DLPFC | ADediting_1401203 | chr8_30101533_+ | 0.934539940902685 | 0.00468380900126208 | 0.205429972988535 | -0.07211481160091 | 5.36615654810448e-10 | 0.343210204387093 |
| DLPFC | ADediting_1401208 | chr8_30101583_+ | 0.877067329927324 | 0.00882114958533445 | 0.0660922400927356 | -0.1045160656013 | 1.26088445359701e-10 | 0.354784220283632 |
| DLPFC | ADediting_1401209 | chr8_30101588_+ | 0.84246962974614 | 0.0113328390352443 | 0.226492095839411 | -0.0688884969343492 | 1.77793368164719e-09 | 0.333264498981649 |
| DLPFC | ADediting_1401210 | chr8_30101589_+ | 0.323033968879561 | 0.0563113299146374 | 0.184909173349709 | -0.0754973117744424 | 1.29411889430775e-13 | 0.40422099359032 |
| DLPFC | ADediting_1401213 | chr8_30108721_+ | 0.00307228880595132 | 0.16762594533172 | 0.0175993940359401 | 0.134759570180809 | 6.9584484599314e-10 | 0.341082624066429 |
| DLPFC | ADediting_1401216 | chr8_30108745_+ | 0.0110613860005317 | 0.144133110037923 | 0.0255895114484315 | 0.126791047485899 | 8.65459492693044e-13 | 0.391380037313823 |
| DLPFC | ADediting_1401218 | chr8_30108848_+ | 0.0386596890556194 | 0.11751015877343 | 0.692103544900992 | -0.0225797516781338 | 3.7343952817493e-24 | 0.533031818641833 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 7.54621198001493e-68 | 0.791563454335627 | 1.9029620924798e-38 | 0.648953594695232 | 0.000347930240911928 | 0.201864418941695 |
| AC | 2.78496854788358e-96 | 0.909073713119231 | 3.19808873435704e-55 | 0.792667488089483 | 4.59163183976466e-16 | 0.483685462659044 |
| PCC | 1.0219601087606e-42 | 0.79399564739169 | 1.6472269362916e-43 | 0.798421988238916 | 0.00755489962252499 | 0.192740821053727 |
| CER | 1.02193408708834e-38 | 0.826238674824813 | 3.06396977411309e-23 | 0.698213785164759 | 0.0504578466208311 | 0.160019710150891 |
| TCX | 7.14032966502323e-52 | 0.888293418923676 | 2.03906576372741e-19 | 0.650611767387042 | 0.0809127708182975 | 0.142975431933341 |
| FP | 5.40955408693654e-22 | 0.641154830185587 | 5.28361118294682e-29 | 0.71357778042803 | 0.3688868061978 | 0.0677498489812425 |
| IFG | 1.18664815351006e-06 | 0.805518814727074 | 0.000241852304960552 | 0.670908452369653 | 0.729838864197171 | 0.0726983774700765 |
| PG | 6.59444466918958e-47 | 0.822210972260458 | 9.28647795418016e-25 | 0.661320695781887 | 0.666711652329651 | -0.0317842083666673 |
| STG | 1.86870103307663e-20 | 0.807068755289501 | 3.10429775761067e-16 | 0.747597902575369 | 0.984604160076803 | 0.0021375037785673 |
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Relation with AD stages for LEPROTL1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| IFG | 0.0205262239543287 | -0.46051461285474 |
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RelatedDrugs for LEPROTL1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LEPROTL1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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