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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for ICMT |
 Gene summary |
| Gene information | Gene symbol | ICMT | Gene ID | 23463 |
| Gene name | isoprenylcysteine carboxyl methyltransferase | |
| Synonyms | HSTE14|MST098|MSTP098|PCCMT|PCMT|PPMT | |
| Cytomap | 1p36.31 | |
| Type of gene | protein-coding | |
| Description | protein-S-isoprenylcysteine O-methyltransferaseprenylated protein carboxyl methyltransferaseprenylcysteine carboxyl methyltransferase | |
| Modification date | 20200313 | |
| UniProtAcc | O60725, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for ICMT |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_132130(6222148, -), ADediting_132131(6222164, -), ADediting_132132(6222176, -), ADediting_132133(6222177, -), ADediting_132134(6222178, -), ADediting_132135(6222195, -), ADediting_132136(6222199, -), ADediting_132137(6222209, -), ADediting_132138(6222216, -), ADediting_132139(6222229, -), ADediting_132140(6222235, -), ADediting_132141(6222238, -), ADediting_132142(6222241, -), ADediting_132143(6222255, -), ADediting_132144(6222258, -), ADediting_132145(6222264, -), ADediting_132146(6222274, -), ADediting_132147(6222275, -), ADediting_132148(6222279, -), ADediting_132149(6222301, -), ADediting_132150(6222311, -), ADediting_132151(6222314, -), ADediting_132152(6222323, -), ADediting_132153(6222340, -), ADediting_132154(6222341, -), ADediting_132155(6222360, -), ADediting_132156(6222361, -), ADediting_132157(6222366, -), ADediting_132158(6222385, -), ADediting_132159(6222427, -), ADediting_132160(6222435, -), ADediting_132161(6222527, -), ADediting_132162(6222709, -), ADediting_132163(6222710, -), ADediting_132164(6223184, -), ADediting_132165(6223200, -), ADediting_132166(6223204, -), ADediting_132167(6223213, -), ADediting_132168(6223216, -), ADediting_132169(6223219, -), ADediting_132170(6223221, -), ADediting_132171(6223223, -), ADediting_132172(6223229, -), ADediting_132173(6223232, -), ADediting_132174(6223236, -), ADediting_132175(6223240, -), ADediting_132176(6223245, -), ADediting_132177(6223246, -), ADediting_132178(6223272, -), ADediting_132179(6223274, -), ADediting_132180(6223275, -), ADediting_132181(6223276, -), ADediting_132182(6223277, -), ADediting_132183(6223278, -), ADediting_132184(6223279, -), ADediting_132185(6223280, -), ADediting_132186(6223282, -), ADediting_132187(6223284, -), ADediting_132188(6223285, -), ADediting_132189(6223286, -), ADediting_132190(6223287, -), ADediting_132191(6223288, -), ADediting_132192(6223291, -), ADediting_132193(6223302, -), ADediting_132194(6223303, -), ADediting_132195(6223304, -), ADediting_132196(6223305, -), ADediting_132197(6223307, -), ADediting_132198(6223312, -), ADediting_132199(6223313, -), ADediting_132200(6223322, -), ADediting_132201(6223336, -), ADediting_132202(6223341, -), ADediting_132203(6223357, -), ADediting_132204(6223358, -), ADediting_132205(6223363, -), ADediting_132206(6223370, -), ADediting_132207(6223374, -), ADediting_132208(6223379, -), ADediting_132209(6223380, -), ADediting_132210(6223388, -), ADediting_132211(6229316, -), ADediting_132212(6230253, -), ADediting_132213(6230255, -), ADediting_132214(6230323, -), ADediting_132215(6230364, -), ADediting_1521194(6222142, -), ADediting_1521195(6222336, -), |
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RNA editing positional annotations for ICMT using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_132130 | chr1_6222148_- | UTR3 |
| ADediting_132131 | chr1_6222164_- | UTR3 |
| ADediting_132132 | chr1_6222176_- | UTR3 |
| ADediting_132133 | chr1_6222177_- | UTR3 |
| ADediting_132134 | chr1_6222178_- | UTR3 |
| ADediting_132135 | chr1_6222195_- | UTR3 |
| ADediting_132136 | chr1_6222199_- | UTR3 |
| ADediting_132137 | chr1_6222209_- | UTR3 |
| ADediting_132138 | chr1_6222216_- | UTR3 |
| ADediting_132139 | chr1_6222229_- | UTR3 |
| ADediting_132140 | chr1_6222235_- | UTR3 |
| ADediting_132141 | chr1_6222238_- | UTR3 |
| ADediting_132142 | chr1_6222241_- | UTR3 |
| ADediting_132143 | chr1_6222255_- | UTR3 |
| ADediting_132144 | chr1_6222258_- | UTR3 |
| ADediting_132145 | chr1_6222264_- | UTR3 |
| ADediting_132146 | chr1_6222274_- | UTR3 |
| ADediting_132147 | chr1_6222275_- | UTR3 |
| ADediting_132148 | chr1_6222279_- | UTR3 |
| ADediting_132149 | chr1_6222301_- | UTR3 |
| ADediting_132150 | chr1_6222311_- | UTR3 |
| ADediting_132151 | chr1_6222314_- | UTR3 |
| ADediting_132152 | chr1_6222323_- | UTR3 |
| ADediting_132153 | chr1_6222340_- | UTR3 |
| ADediting_132154 | chr1_6222341_- | UTR3 |
| ADediting_132155 | chr1_6222360_- | UTR3 |
| ADediting_132156 | chr1_6222361_- | UTR3 |
| ADediting_132157 | chr1_6222366_- | UTR3 |
| ADediting_132158 | chr1_6222385_- | UTR3 |
| ADediting_132159 | chr1_6222427_- | UTR3 |
| ADediting_132160 | chr1_6222435_- | UTR3 |
| ADediting_132161 | chr1_6222527_- | UTR3 |
| ADediting_132162 | chr1_6222709_- | UTR3 |
| ADediting_132163 | chr1_6222710_- | UTR3 |
| ADediting_132164 | chr1_6223184_- | UTR3 |
| ADediting_132165 | chr1_6223200_- | UTR3 |
| ADediting_132166 | chr1_6223204_- | UTR3 |
| ADediting_132167 | chr1_6223213_- | UTR3 |
| ADediting_132168 | chr1_6223216_- | UTR3 |
| ADediting_132169 | chr1_6223219_- | UTR3 |
| ADediting_132170 | chr1_6223221_- | UTR3 |
| ADediting_132171 | chr1_6223223_- | UTR3 |
| ADediting_132172 | chr1_6223229_- | UTR3 |
| ADediting_132173 | chr1_6223232_- | UTR3 |
| ADediting_132174 | chr1_6223236_- | UTR3 |
| ADediting_132175 | chr1_6223240_- | UTR3 |
| ADediting_132176 | chr1_6223245_- | UTR3 |
| ADediting_132177 | chr1_6223246_- | UTR3 |
| ADediting_132178 | chr1_6223272_- | UTR3 |
| ADediting_132179 | chr1_6223274_- | UTR3 |
| ADediting_132180 | chr1_6223275_- | UTR3 |
| ADediting_132181 | chr1_6223276_- | UTR3 |
| ADediting_132182 | chr1_6223277_- | UTR3 |
| ADediting_132183 | chr1_6223278_- | UTR3 |
| ADediting_132184 | chr1_6223279_- | UTR3 |
| ADediting_132185 | chr1_6223280_- | UTR3 |
| ADediting_132186 | chr1_6223282_- | UTR3 |
| ADediting_132187 | chr1_6223284_- | UTR3 |
| ADediting_132188 | chr1_6223285_- | UTR3 |
| ADediting_132189 | chr1_6223286_- | UTR3 |
| ADediting_132190 | chr1_6223287_- | UTR3 |
| ADediting_132191 | chr1_6223288_- | UTR3 |
| ADediting_132192 | chr1_6223291_- | UTR3 |
| ADediting_132193 | chr1_6223302_- | UTR3 |
| ADediting_132194 | chr1_6223303_- | UTR3 |
| ADediting_132195 | chr1_6223304_- | UTR3 |
| ADediting_132196 | chr1_6223305_- | UTR3 |
| ADediting_132197 | chr1_6223307_- | UTR3 |
| ADediting_132198 | chr1_6223312_- | UTR3 |
| ADediting_132199 | chr1_6223313_- | UTR3 |
| ADediting_132200 | chr1_6223322_- | UTR3 |
| ADediting_132201 | chr1_6223336_- | UTR3 |
| ADediting_132202 | chr1_6223341_- | UTR3 |
| ADediting_132203 | chr1_6223357_- | UTR3 |
| ADediting_132204 | chr1_6223358_- | UTR3 |
| ADediting_132205 | chr1_6223363_- | UTR3 |
| ADediting_132206 | chr1_6223370_- | UTR3 |
| ADediting_132207 | chr1_6223374_- | UTR3 |
| ADediting_132208 | chr1_6223379_- | UTR3 |
| ADediting_132209 | chr1_6223380_- | UTR3 |
| ADediting_132210 | chr1_6223388_- | UTR3 |
| ADediting_132211 | chr1_6229316_- | intronic |
| ADediting_132212 | chr1_6230253_- | intronic |
| ADediting_132213 | chr1_6230255_- | intronic |
| ADediting_132214 | chr1_6230323_- | intronic |
| ADediting_132215 | chr1_6230364_- | intronic |
| ADediting_1521194 | chr1_6222142_- | UTR3 |
| ADediting_1521195 | chr1_6222336_- | UTR3 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_132130 | chr1_6222148_- | SINE | Alu | Name=AluSz |
| ADediting_132131 | chr1_6222164_- | SINE | Alu | Name=AluSz |
| ADediting_132132 | chr1_6222176_- | SINE | Alu | Name=AluSz |
| ADediting_132133 | chr1_6222177_- | SINE | Alu | Name=AluSz |
| ADediting_132134 | chr1_6222178_- | SINE | Alu | Name=AluSz |
| ADediting_132135 | chr1_6222195_- | SINE | Alu | Name=AluSz |
| ADediting_132136 | chr1_6222199_- | SINE | Alu | Name=AluSz |
| ADediting_132137 | chr1_6222209_- | SINE | Alu | Name=AluSz |
| ADediting_132138 | chr1_6222216_- | SINE | Alu | Name=AluSz |
| ADediting_132139 | chr1_6222229_- | SINE | Alu | Name=AluSz |
| ADediting_132140 | chr1_6222235_- | SINE | Alu | Name=AluSz |
| ADediting_132141 | chr1_6222238_- | SINE | Alu | Name=AluSz |
| ADediting_132142 | chr1_6222241_- | SINE | Alu | Name=AluSz |
| ADediting_132143 | chr1_6222255_- | SINE | Alu | Name=AluSz |
| ADediting_132144 | chr1_6222258_- | SINE | Alu | Name=AluSz |
| ADediting_132145 | chr1_6222264_- | SINE | Alu | Name=AluSz |
| ADediting_132146 | chr1_6222274_- | SINE | Alu | Name=AluSz |
| ADediting_132147 | chr1_6222275_- | SINE | Alu | Name=AluSz |
| ADediting_132148 | chr1_6222279_- | SINE | Alu | Name=AluSz |
| ADediting_132149 | chr1_6222301_- | SINE | Alu | Name=AluSz |
| ADediting_132150 | chr1_6222311_- | SINE | Alu | Name=AluSz |
| ADediting_132151 | chr1_6222314_- | SINE | Alu | Name=AluSz |
| ADediting_132152 | chr1_6222323_- | SINE | Alu | Name=AluSz |
| ADediting_132153 | chr1_6222340_- | SINE | Alu | Name=AluSz |
| ADediting_132154 | chr1_6222341_- | SINE | Alu | Name=AluSz |
| ADediting_132155 | chr1_6222360_- | SINE | Alu | Name=AluSz |
| ADediting_132156 | chr1_6222361_- | SINE | Alu | Name=AluSz |
| ADediting_132157 | chr1_6222366_- | SINE | Alu | Name=AluSz |
| ADediting_132158 | chr1_6222385_- | SINE | Alu | Name=AluSz |
| ADediting_132159 | chr1_6222427_- | SINE | Alu | Name=AluSz |
| ADediting_132160 | chr1_6222435_- | SINE | Alu | Name=AluSz |
| ADediting_132164 | chr1_6223184_- | SINE | Alu | Name=AluSx3 |
| ADediting_132165 | chr1_6223200_- | SINE | Alu | Name=AluSx3 |
| ADediting_132166 | chr1_6223204_- | SINE | Alu | Name=AluSx3 |
| ADediting_132167 | chr1_6223213_- | SINE | Alu | Name=AluSx3 |
| ADediting_132168 | chr1_6223216_- | SINE | Alu | Name=AluSx3 |
| ADediting_132169 | chr1_6223219_- | SINE | Alu | Name=AluSx3 |
| ADediting_132170 | chr1_6223221_- | SINE | Alu | Name=AluSx3 |
| ADediting_132171 | chr1_6223223_- | SINE | Alu | Name=AluSx3 |
| ADediting_132172 | chr1_6223229_- | SINE | Alu | Name=AluSx3 |
| ADediting_132173 | chr1_6223232_- | SINE | Alu | Name=AluSx3 |
| ADediting_132174 | chr1_6223236_- | SINE | Alu | Name=AluSx3 |
| ADediting_132175 | chr1_6223240_- | SINE | Alu | Name=AluSx3 |
| ADediting_132176 | chr1_6223245_- | SINE | Alu | Name=AluSx3 |
| ADediting_132177 | chr1_6223246_- | SINE | Alu | Name=AluSx3 |
| ADediting_132178 | chr1_6223272_- | SINE | Alu | Name=AluSx3 |
| ADediting_132179 | chr1_6223274_- | SINE | Alu | Name=AluSx3 |
| ADediting_132180 | chr1_6223275_- | SINE | Alu | Name=AluSx3 |
| ADediting_132181 | chr1_6223276_- | SINE | Alu | Name=AluSx3 |
| ADediting_132182 | chr1_6223277_- | SINE | Alu | Name=AluSx3 |
| ADediting_132183 | chr1_6223278_- | SINE | Alu | Name=AluSx3 |
| ADediting_132184 | chr1_6223279_- | SINE | Alu | Name=AluSx3 |
| ADediting_132185 | chr1_6223280_- | SINE | Alu | Name=AluSx3 |
| ADediting_132186 | chr1_6223282_- | SINE | Alu | Name=AluSx3 |
| ADediting_132187 | chr1_6223284_- | SINE | Alu | Name=AluSx3 |
| ADediting_132188 | chr1_6223285_- | SINE | Alu | Name=AluSx3 |
| ADediting_132189 | chr1_6223286_- | SINE | Alu | Name=AluSx3 |
| ADediting_132190 | chr1_6223287_- | SINE | Alu | Name=AluSx3 |
| ADediting_132191 | chr1_6223288_- | SINE | Alu | Name=AluSx3 |
| ADediting_132192 | chr1_6223291_- | SINE | Alu | Name=AluSx3 |
| ADediting_132193 | chr1_6223302_- | SINE | Alu | Name=AluSx3 |
| ADediting_132194 | chr1_6223303_- | SINE | Alu | Name=AluSx3 |
| ADediting_132195 | chr1_6223304_- | SINE | Alu | Name=AluSx3 |
| ADediting_132196 | chr1_6223305_- | SINE | Alu | Name=AluSx3 |
| ADediting_132197 | chr1_6223307_- | SINE | Alu | Name=AluSx3 |
| ADediting_132198 | chr1_6223312_- | SINE | Alu | Name=AluSx3 |
| ADediting_132199 | chr1_6223313_- | SINE | Alu | Name=AluSx3 |
| ADediting_132200 | chr1_6223322_- | SINE | Alu | Name=AluSx3 |
| ADediting_132201 | chr1_6223336_- | SINE | Alu | Name=AluSx3 |
| ADediting_132202 | chr1_6223341_- | SINE | Alu | Name=AluSx3 |
| ADediting_132203 | chr1_6223357_- | SINE | Alu | Name=AluSx3 |
| ADediting_132204 | chr1_6223358_- | SINE | Alu | Name=AluSx3 |
| ADediting_132205 | chr1_6223363_- | SINE | Alu | Name=AluSx3 |
| ADediting_132206 | chr1_6223370_- | SINE | Alu | Name=AluSx3 |
| ADediting_132207 | chr1_6223374_- | SINE | Alu | Name=AluSx3 |
| ADediting_132208 | chr1_6223379_- | SINE | Alu | Name=AluSx3 |
| ADediting_132209 | chr1_6223380_- | SINE | Alu | Name=AluSx3 |
| ADediting_132210 | chr1_6223388_- | SINE | Alu | Name=AluSx3 |
| ADediting_132211 | chr1_6229316_- | SINE | Alu | Name=AluSp |
| ADediting_132212 | chr1_6230253_- | SINE | Alu | Name=AluSz6 |
| ADediting_132213 | chr1_6230255_- | SINE | Alu | Name=AluSz6 |
| ADediting_132214 | chr1_6230323_- | SINE | Alu | Name=AluSz6 |
| ADediting_132215 | chr1_6230364_- | SINE | Alu | Name=AluSz6 |
| ADediting_1521194 | chr1_6222142_- | SINE | Alu | Name=AluSz |
| ADediting_1521195 | chr1_6222336_- | SINE | Alu | Name=AluSz |
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RNA A-to-I editing events in the alternative splicing sites for ICMT |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ICMT |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |