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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for TARDBP |
 Gene summary |
| Gene information | Gene symbol | TARDBP | Gene ID | 23435 |
| Gene name | TAR DNA binding protein | |
| Synonyms | ALS10|TDP-43 | |
| Cytomap | 1p36.22 | |
| Type of gene | protein-coding | |
| Description | TAR DNA-binding protein 43TAR DNA-binding protein-43 | |
| Modification date | 20200329 | |
| UniProtAcc | Q13148, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TARDBP | GO:0008380 | RNA splicing | 11285240 |
| TARDBP | GO:0043922 | negative regulation by host of viral transcription | 7745706 |
| TARDBP | GO:0061158 | 3'-UTR-mediated mRNA destabilization | 28335005 |
| TARDBP | GO:0070935 | 3'-UTR-mediated mRNA stabilization | 17481916 |
Top |
RNA A-to-I events for TARDBP |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_6170(11014661, +), ADediting_6171(11015046, +), ADediting_6173(11015295, +), ADediting_6174(11015365, +), ADediting_6175(11015429, +), ADediting_6176(11015430, +), ADediting_6179(11016037, +), ADediting_6180(11016038, +), ADediting_6191(11020651, +), ADediting_6192(11020653, +), ADediting_6193(11020654, +), ADediting_6194(11020659, +), ADediting_6195(11020662, +), ADediting_6196(11020691, +), ADediting_6197(11020704, +), ADediting_6198(11020705, +), ADediting_6199(11020720, +), ADediting_6200(11020729, +), ADediting_6201(11020730, +), ADediting_6202(11020764, +), ADediting_6203(11020799, +), ADediting_6204(11020803, +), ADediting_6205(11020816, +), ADediting_6206(11020835, +), ADediting_6207(11020848, +), ADediting_6208(11020855, +), ADediting_6209(11020859, +), ADediting_6210(11020860, +), ADediting_6211(11020869, +), ADediting_6212(11020871, +), ADediting_6213(11020884, +), ADediting_6214(11020889, +), ADediting_6215(11021189, +), ADediting_6216(11021203, +), ADediting_6217(11021218, +), ADediting_6218(11021225, +), ADediting_6219(11021238, +), ADediting_6220(11021239, +), ADediting_6221(11021256, +), ADediting_6222(11021268, +), ADediting_6223(11021280, +), ADediting_6224(11021321, +), ADediting_6225(11021330, +), ADediting_6226(11021350, +), ADediting_6227(11021393, +), ADediting_6228(11021403, +), ADediting_6229(11021415, +), ADediting_6230(11021417, +), ADediting_6231(11021457, +), ADediting_6232(11021521, +), ADediting_6233(11021530, +), ADediting_6234(11021539, +), ADediting_6235(11021540, +), ADediting_6236(11021552, +), ADediting_6237(11021610, +), ADediting_6238(11021630, +), ADediting_6239(11021643, +), ADediting_6240(11021653, +), ADediting_6241(11021654, +), ADediting_6242(11021659, +), ADediting_6243(11021667, +), ADediting_6244(11021718, +), ADediting_6245(11021734, +), ADediting_6246(11021792, +), ADediting_6247(11021831, +), ADediting_6248(11021864, +), ADediting_6249(11021878, +), ADediting_6250(11021879, +), ADediting_6251(11021885, +), ADediting_6252(11021891, +), ADediting_6253(11021893, +), ADediting_6275(11026305, +), ADediting_1513799(11020688, +), ADediting_1513800(11020696, +), ADediting_1513801(11020719, +), ADediting_1513802(11020728, +), ADediting_1513803(11020826, +), ADediting_1513804(11021230, +), ADediting_1513805(11021402, +), ADediting_1513806(11021826, +), ADediting_1596002(11021324, +), |
Top |
RNA editing positional annotations for TARDBP using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_6170 | chr1_11014661_+ | intronic |
| ADediting_6171 | chr1_11015046_+ | intronic |
| ADediting_6173 | chr1_11015295_+ | intronic |
| ADediting_6174 | chr1_11015365_+ | intronic |
| ADediting_6175 | chr1_11015429_+ | intronic |
| ADediting_6176 | chr1_11015430_+ | intronic |
| ADediting_6179 | chr1_11016037_+ | intronic |
| ADediting_6180 | chr1_11016038_+ | intronic |
| ADediting_6191 | chr1_11020651_+ | intronic |
| ADediting_6192 | chr1_11020653_+ | intronic |
| ADediting_6193 | chr1_11020654_+ | intronic |
| ADediting_6194 | chr1_11020659_+ | intronic |
| ADediting_6195 | chr1_11020662_+ | intronic |
| ADediting_6196 | chr1_11020691_+ | intronic |
| ADediting_6197 | chr1_11020704_+ | intronic |
| ADediting_6198 | chr1_11020705_+ | intronic |
| ADediting_6199 | chr1_11020720_+ | intronic |
| ADediting_6200 | chr1_11020729_+ | intronic |
| ADediting_6201 | chr1_11020730_+ | intronic |
| ADediting_6202 | chr1_11020764_+ | intronic |
| ADediting_6203 | chr1_11020799_+ | intronic |
| ADediting_6204 | chr1_11020803_+ | intronic |
| ADediting_6205 | chr1_11020816_+ | intronic |
| ADediting_6206 | chr1_11020835_+ | intronic |
| ADediting_6207 | chr1_11020848_+ | intronic |
| ADediting_6208 | chr1_11020855_+ | intronic |
| ADediting_6209 | chr1_11020859_+ | intronic |
| ADediting_6210 | chr1_11020860_+ | intronic |
| ADediting_6211 | chr1_11020869_+ | intronic |
| ADediting_6212 | chr1_11020871_+ | intronic |
| ADediting_6213 | chr1_11020884_+ | intronic |
| ADediting_6214 | chr1_11020889_+ | intronic |
| ADediting_6215 | chr1_11021189_+ | intronic |
| ADediting_6216 | chr1_11021203_+ | intronic |
| ADediting_6217 | chr1_11021218_+ | intronic |
| ADediting_6218 | chr1_11021225_+ | intronic |
| ADediting_6219 | chr1_11021238_+ | intronic |
| ADediting_6220 | chr1_11021239_+ | intronic |
| ADediting_6221 | chr1_11021256_+ | intronic |
| ADediting_6222 | chr1_11021268_+ | intronic |
| ADediting_6223 | chr1_11021280_+ | intronic |
| ADediting_6224 | chr1_11021321_+ | intronic |
| ADediting_6225 | chr1_11021330_+ | intronic |
| ADediting_6226 | chr1_11021350_+ | intronic |
| ADediting_6227 | chr1_11021393_+ | intronic |
| ADediting_6228 | chr1_11021403_+ | intronic |
| ADediting_6229 | chr1_11021415_+ | intronic |
| ADediting_6230 | chr1_11021417_+ | intronic |
| ADediting_6231 | chr1_11021457_+ | intronic |
| ADediting_6232 | chr1_11021521_+ | intronic |
| ADediting_6233 | chr1_11021530_+ | intronic |
| ADediting_6234 | chr1_11021539_+ | intronic |
| ADediting_6235 | chr1_11021540_+ | intronic |
| ADediting_6236 | chr1_11021552_+ | intronic |
| ADediting_6237 | chr1_11021610_+ | intronic |
| ADediting_6238 | chr1_11021630_+ | intronic |
| ADediting_6239 | chr1_11021643_+ | intronic |
| ADediting_6240 | chr1_11021653_+ | intronic |
| ADediting_6241 | chr1_11021654_+ | intronic |
| ADediting_6242 | chr1_11021659_+ | intronic |
| ADediting_6243 | chr1_11021667_+ | intronic |
| ADediting_6244 | chr1_11021718_+ | intronic |
| ADediting_6245 | chr1_11021734_+ | intronic |
| ADediting_6246 | chr1_11021792_+ | intronic |
| ADediting_6247 | chr1_11021831_+ | intronic |
| ADediting_6248 | chr1_11021864_+ | intronic |
| ADediting_6249 | chr1_11021878_+ | intronic |
| ADediting_6250 | chr1_11021879_+ | intronic |
| ADediting_6251 | chr1_11021885_+ | intronic |
| ADediting_6252 | chr1_11021891_+ | intronic |
| ADediting_6253 | chr1_11021893_+ | intronic |
| ADediting_6275 | chr1_11026305_+ | UTR3 |
| ADediting_1513799 | chr1_11020688_+ | intronic |
| ADediting_1513800 | chr1_11020696_+ | intronic |
| ADediting_1513801 | chr1_11020719_+ | intronic |
| ADediting_1513802 | chr1_11020728_+ | intronic |
| ADediting_1513803 | chr1_11020826_+ | intronic |
| ADediting_1513804 | chr1_11021230_+ | intronic |
| ADediting_1513805 | chr1_11021402_+ | intronic |
| ADediting_1513806 | chr1_11021826_+ | intronic |
| ADediting_1596002 | chr1_11021324_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_6170 | chr1_11014661_+ | SINE | Alu | Name=AluSq2 |
| ADediting_6171 | chr1_11015046_+ | SINE | Alu | Name=AluSc |
| ADediting_6173 | chr1_11015295_+ | SINE | Alu | Name=AluSx |
| ADediting_6174 | chr1_11015365_+ | SINE | Alu | Name=AluSx |
| ADediting_6175 | chr1_11015429_+ | SINE | Alu | Name=AluSx |
| ADediting_6176 | chr1_11015430_+ | SINE | Alu | Name=AluSx |
| ADediting_6179 | chr1_11016037_+ | SINE | Alu | Name=AluSg4 |
| ADediting_6180 | chr1_11016038_+ | SINE | Alu | Name=AluSg4 |
| ADediting_6191 | chr1_11020651_+ | SINE | Alu | Name=AluSc |
| ADediting_6192 | chr1_11020653_+ | SINE | Alu | Name=AluSc |
| ADediting_6193 | chr1_11020654_+ | SINE | Alu | Name=AluSc |
| ADediting_6194 | chr1_11020659_+ | SINE | Alu | Name=AluSc |
| ADediting_6195 | chr1_11020662_+ | SINE | Alu | Name=AluSc |
| ADediting_6196 | chr1_11020691_+ | SINE | Alu | Name=AluSc |
| ADediting_6197 | chr1_11020704_+ | SINE | Alu | Name=AluSc |
| ADediting_6198 | chr1_11020705_+ | SINE | Alu | Name=AluSc |
| ADediting_6199 | chr1_11020720_+ | SINE | Alu | Name=AluSc |
| ADediting_6200 | chr1_11020729_+ | SINE | Alu | Name=AluSc |
| ADediting_6201 | chr1_11020730_+ | SINE | Alu | Name=AluSc |
| ADediting_6202 | chr1_11020764_+ | SINE | Alu | Name=AluSc |
| ADediting_6203 | chr1_11020799_+ | SINE | Alu | Name=AluSc |
| ADediting_6204 | chr1_11020803_+ | SINE | Alu | Name=AluSc |
| ADediting_6205 | chr1_11020816_+ | SINE | Alu | Name=AluSc |
| ADediting_6206 | chr1_11020835_+ | SINE | Alu | Name=AluSc |
| ADediting_6207 | chr1_11020848_+ | SINE | Alu | Name=AluSc |
| ADediting_6208 | chr1_11020855_+ | SINE | Alu | Name=AluSc |
| ADediting_6209 | chr1_11020859_+ | SINE | Alu | Name=AluSc |
| ADediting_6210 | chr1_11020860_+ | SINE | Alu | Name=AluSc |
| ADediting_6211 | chr1_11020869_+ | SINE | Alu | Name=AluSc |
| ADediting_6212 | chr1_11020871_+ | SINE | Alu | Name=AluSc |
| ADediting_6213 | chr1_11020884_+ | SINE | Alu | Name=AluSc |
| ADediting_6214 | chr1_11020889_+ | SINE | Alu | Name=AluSc |
| ADediting_6215 | chr1_11021189_+ | SINE | Alu | Name=AluSq2 |
| ADediting_6216 | chr1_11021203_+ | SINE | Alu | Name=AluSq2 |
| ADediting_6217 | chr1_11021218_+ | SINE | Alu | Name=AluSq2 |
| ADediting_6218 | chr1_11021225_+ | SINE | Alu | Name=AluSq2 |
| ADediting_6219 | chr1_11021238_+ | SINE | Alu | Name=AluSq2 |
| ADediting_6220 | chr1_11021239_+ | SINE | Alu | Name=AluSq2 |
| ADediting_6221 | chr1_11021256_+ | SINE | Alu | Name=AluSq2 |
| ADediting_6222 | chr1_11021268_+ | SINE | Alu | Name=AluSq2 |
| ADediting_6223 | chr1_11021280_+ | SINE | Alu | Name=AluSq2 |
| ADediting_6224 | chr1_11021321_+ | SINE | Alu | Name=AluSq2 |
| ADediting_6225 | chr1_11021330_+ | SINE | Alu | Name=AluSq2 |
| ADediting_6226 | chr1_11021350_+ | SINE | Alu | Name=AluSq2 |
| ADediting_6227 | chr1_11021393_+ | SINE | Alu | Name=AluSq2 |
| ADediting_6228 | chr1_11021403_+ | SINE | Alu | Name=AluSq2 |
| ADediting_6229 | chr1_11021415_+ | SINE | Alu | Name=AluSq2 |
| ADediting_6230 | chr1_11021417_+ | SINE | Alu | Name=AluSq2 |
| ADediting_6231 | chr1_11021457_+ | SINE | Alu | Name=AluSx |
| ADediting_6232 | chr1_11021521_+ | SINE | Alu | Name=AluSx |
| ADediting_6233 | chr1_11021530_+ | SINE | Alu | Name=AluSx |
| ADediting_6234 | chr1_11021539_+ | SINE | Alu | Name=AluSx |
| ADediting_6235 | chr1_11021540_+ | SINE | Alu | Name=AluSx |
| ADediting_6236 | chr1_11021552_+ | SINE | Alu | Name=AluSx |
| ADediting_6237 | chr1_11021610_+ | SINE | Alu | Name=AluJr |
| ADediting_6238 | chr1_11021630_+ | SINE | Alu | Name=AluJr |
| ADediting_6239 | chr1_11021643_+ | SINE | Alu | Name=AluJr |
| ADediting_6240 | chr1_11021653_+ | SINE | Alu | Name=AluJr |
| ADediting_6241 | chr1_11021654_+ | SINE | Alu | Name=AluJr |
| ADediting_6242 | chr1_11021659_+ | SINE | Alu | Name=AluJr |
| ADediting_6243 | chr1_11021667_+ | SINE | Alu | Name=AluJr |
| ADediting_6244 | chr1_11021718_+ | SINE | Alu | Name=AluJr |
| ADediting_6245 | chr1_11021734_+ | SINE | Alu | Name=AluJr |
| ADediting_6246 | chr1_11021792_+ | SINE | Alu | Name=AluJr |
| ADediting_6247 | chr1_11021831_+ | SINE | Alu | Name=AluJr |
| ADediting_6248 | chr1_11021864_+ | SINE | Alu | Name=AluJr |
| ADediting_6249 | chr1_11021878_+ | SINE | Alu | Name=AluJr |
| ADediting_6250 | chr1_11021879_+ | SINE | Alu | Name=AluJr |
| ADediting_6251 | chr1_11021885_+ | SINE | Alu | Name=AluJr |
| ADediting_6252 | chr1_11021891_+ | SINE | Alu | Name=AluJr |
| ADediting_6253 | chr1_11021893_+ | SINE | Alu | Name=AluJr |
| ADediting_1513799 | chr1_11020688_+ | SINE | Alu | Name=AluSc |
| ADediting_1513800 | chr1_11020696_+ | SINE | Alu | Name=AluSc |
| ADediting_1513801 | chr1_11020719_+ | SINE | Alu | Name=AluSc |
| ADediting_1513802 | chr1_11020728_+ | SINE | Alu | Name=AluSc |
| ADediting_1513803 | chr1_11020826_+ | SINE | Alu | Name=AluSc |
| ADediting_1513804 | chr1_11021230_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1513805 | chr1_11021402_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1513806 | chr1_11021826_+ | SINE | Alu | Name=AluJr |
| ADediting_1596002 | chr1_11021324_+ | SINE | Alu | Name=AluSq2 |
Top |
RNA A-to-I editing events in the alternative splicing sites for TARDBP |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for TARDBP |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for TARDBP |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for TARDBP |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000120948.17 | ENST00000240185.7 | TARDBP-201 | hsa-miR-5688 | chr1 | 11024925 | 11024932 | 8mer-1a | 11024913 | 11024932 | 149 | -13.58 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000120948.17 | ENST00000240185.7 | TARDBP-201 | hsa-miR-381-3p | chr1 | 11024254 | 11024260 | 7mer-m8 | 11024240 | 11024261 | 158 | -17.92 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000120948.17 | ENST00000240185.7 | TARDBP-201 | hsa-miR-5688 | chr1 | 11022761 | 11022767 | 7mer-m8 | 11022746 | 11022768 | 149 | -8.79 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000120948.17 | ENST00000639083.1 | TARDBP-230 | hsa-miR-5688 | chr1 | 11022761 | 11022767 | 7mer-m8 | 11022746 | 11022768 | 149 | -8.79 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000120948.17 | ENST00000240185.7 | TARDBP-201 | hsa-miR-4477b | chr1 | 11023065 | 11023071 | 7mer-m8 | 11023051 | 11023072 | 142 | -7.17 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000120948.17 | ENST00000639083.1 | TARDBP-230 | hsa-miR-4477b | chr1 | 11023065 | 11023071 | 7mer-m8 | 11023051 | 11023072 | 142 | -7.17 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000120948.17 | ENST00000240185.7 | TARDBP-201 | hsa-miR-4477b | chr1 | 11023065 | 11023071 | 7mer-m8 | 11023051 | 11023072 | 142 | -7.17 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000120948.17 | ENST00000639083.1 | TARDBP-230 | hsa-miR-4477b | chr1 | 11023065 | 11023071 | 7mer-m8 | 11023051 | 11023072 | 142 | -7.17 |
| ADediting_291761 | chr11_93733708_- | ENSG00000120948.17 | ENST00000240185.7 | TARDBP-201 | hsa-miR-1304-3p | chr1 | 11023888 | 11023894 | 7mer-m8 | 11023873 | 11023895 | 146 | -14.28 |
| ADediting_291761 | chr11_93733708_- | ENSG00000120948.17 | ENST00000315091.7 | TARDBP-202 | hsa-miR-1304-3p | chr1 | 11023888 | 11023894 | 7mer-m8 | 11023873 | 11023895 | 146 | -14.28 |
| ADediting_291761 | chr11_93733708_- | ENSG00000120948.17 | ENST00000610369.4 | TARDBP-211 | hsa-miR-1304-3p | chr1 | 11023888 | 11023894 | 7mer-m8 | 11023873 | 11023895 | 146 | -14.28 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for TARDBP |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000240185.7 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_6275 | ENST00000240185.7 | chr1_11026305_+ | 5252 | -1571.10 | -1566.70 | -1571.10 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for TARDBP |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 7.99420657086827e-77 | 0.820604227272655 | 4.55794024823388e-47 | 0.700638680074313 | 2.04683194797073e-16 | 0.444109190433341 |
| AC | 4.45276884735881e-71 | 0.850272639301499 | 2.25092365811919e-40 | 0.714655004347291 | 2.05535585765078e-19 | 0.528808390516404 |
| PCC | 9.70075363511091e-28 | 0.684456401686704 | 1.03213776425669e-25 | 0.66463560354938 | 0.00282134211971759 | 0.214978739262426 |
| CER | 4.16159149211009e-37 | 0.81634744720084 | 2.09165568144681e-39 | 0.830289325361533 | 0.000214124082598984 | 0.297848230011206 |
| TCX | 1.67021114441197e-29 | 0.760120160231731 | 3.39985080632515e-05 | 0.331577554965268 | 2.20107018924038e-13 | 0.552880977041158 |
| FP | 1.80254056883687e-40 | 0.797475184465389 | 6.04377716451992e-24 | 0.663467784532219 | 5.38192795819573e-07 | 0.365193720128841 |
| IFG | 8.2245342266382e-09 | 0.877828369358331 | 3.06522878828096e-05 | 0.733117739644386 | 0.0133233489367589 | 0.488039035705875 |
| PG | 4.39171144729299e-60 | 0.875718691086793 | 1.35746547839283e-33 | 0.740556474979865 | 0.471906508002595 | 0.0530681020076405 |
| STG | 3.68697907937021e-13 | 0.690459661926284 | 3.51064530627374e-12 | 0.669008811292676 | 0.168250959723898 | 0.15173681290652 |
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Relation with AD stages for TARDBP |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 3.8381504789989e-08 | 0.499112508587448 |
| TCX | 1.50987579965266e-07 | 0.483606114486577 |
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RelatedDrugs for TARDBP |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TARDBP |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TARDBP | C2677565 | AMYOTROPHIC LATERAL SCLEROSIS 10 (disorder) | 13 | UNIPROT |
| TARDBP | C3148872 | FRONTOTEMPORAL DEMENTIA WITH TDP43 INCLUSIONS, TARDBP-RELATED | 13 | UNIPROT |
| TARDBP | C3150169 | FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED | 13 | UNIPROT |
| TARDBP | C3150171 | FTLD-TDP, TARDBP-RELATED | 13 | UNIPROT |
| TARDBP | C0002736 | Amyotrophic Lateral Sclerosis | 6 | CTD_human;ORPHANET |
| TARDBP | C0393554 | Amyotrophic Lateral Sclerosis With Dementia | 6 | CTD_human |
| TARDBP | C0543859 | Amyotrophic Lateral Sclerosis, Guam Form | 6 | CTD_human |
| TARDBP | C0751072 | Frontotemporal Lobar Degeneration | 2 | CTD_human |
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