ADeditome: functional annotation of RNA A-to-I editing in AD

Gene summary for ICOSLG

Gene summary

Gene information	Gene symbol	ICOSLG
	Gene ID	23308
	Gene name	inducible T cell costimulator ligand
	Synonyms	B7-H2\|B7H2\|B7RP-1\|B7RP1\|B7h\|CD275\|GL50\|ICOS-L\|ICOSL\|LICOS
	Cytomap	21q22.3
	Type of gene	protein-coding
	Description	ICOS ligandB7 homolog 2B7 homologue 2B7-like protein Gl50B7-related protein 1transmembrane protein B7-H2 ICOS ligand
	Modification date	20200313
	UniProtAcc	O75144,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for ICOSLG

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_963555(44223827, -), ADediting_963556(44223840, -), ADediting_963557(44223864, -), ADediting_963558(44223918, -), ADediting_963559(44223966, -), ADediting_963560(44223982, -), ADediting_963561(44223986, -), ADediting_963562(44224294, -), ADediting_963563(44224447, -), ADediting_963564(44224459, -), ADediting_963565(44224460, -), ADediting_963566(44224474, -), ADediting_963567(44224485, -), ADediting_963568(44224486, -), ADediting_963569(44224487, -), ADediting_963570(44224500, -), ADediting_963571(44224501, -), ADediting_963572(44224512, -), ADediting_963573(44224521, -), ADediting_963574(44224524, -), ADediting_963575(44224532, -), ADediting_963576(44224538, -), ADediting_963577(44224541, -), ADediting_963578(44224547, -), ADediting_963579(44224563, -), ADediting_963580(44224579, -), ADediting_963581(44224589, -), ADediting_963582(44224592, -), ADediting_963583(44224593, -), ADediting_963584(44224601, -), ADediting_963585(44224611, -), ADediting_963586(44224615, -), ADediting_963587(44224621, -), ADediting_963588(44224635, -), ADediting_963589(44224636, -), ADediting_963590(44224651, -), ADediting_963591(44224679, -), ADediting_963592(44224684, -), ADediting_963593(44224688, -), ADediting_963594(44225222, -), ADediting_1569136(44224281, -), ADediting_1569137(44224295, -), ADediting_1569138(44224303, -), ADediting_1569139(44224429, -), ADediting_1569140(44224461, -), ADediting_1569141(44224482, -), ADediting_1569142(44224664, -), ADediting_1569143(44232657, -), ADediting_1569144(44232673, -),

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RNA editing positional annotations for ICOSLG using Annovar

Protein coding RNA editing(s).

ADeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_963555	chr21_44223827_-	UTR3
ADediting_963556	chr21_44223840_-	UTR3
ADediting_963557	chr21_44223864_-	UTR3
ADediting_963558	chr21_44223918_-	UTR3
ADediting_963559	chr21_44223966_-	UTR3
ADediting_963560	chr21_44223982_-	UTR3
ADediting_963561	chr21_44223986_-	UTR3
ADediting_963562	chr21_44224294_-	UTR3
ADediting_963563	chr21_44224447_-	UTR3
ADediting_963564	chr21_44224459_-	UTR3
ADediting_963565	chr21_44224460_-	UTR3
ADediting_963566	chr21_44224474_-	UTR3
ADediting_963567	chr21_44224485_-	UTR3
ADediting_963568	chr21_44224486_-	UTR3
ADediting_963569	chr21_44224487_-	UTR3
ADediting_963570	chr21_44224500_-	UTR3
ADediting_963571	chr21_44224501_-	UTR3
ADediting_963572	chr21_44224512_-	UTR3
ADediting_963573	chr21_44224521_-	UTR3
ADediting_963574	chr21_44224524_-	UTR3
ADediting_963575	chr21_44224532_-	UTR3
ADediting_963576	chr21_44224538_-	UTR3
ADediting_963577	chr21_44224541_-	UTR3
ADediting_963578	chr21_44224547_-	UTR3
ADediting_963579	chr21_44224563_-	UTR3
ADediting_963580	chr21_44224579_-	UTR3
ADediting_963581	chr21_44224589_-	UTR3
ADediting_963582	chr21_44224592_-	UTR3
ADediting_963583	chr21_44224593_-	UTR3
ADediting_963584	chr21_44224601_-	UTR3
ADediting_963585	chr21_44224611_-	UTR3
ADediting_963586	chr21_44224615_-	UTR3
ADediting_963587	chr21_44224621_-	UTR3
ADediting_963588	chr21_44224635_-	UTR3
ADediting_963589	chr21_44224636_-	UTR3
ADediting_963590	chr21_44224651_-	UTR3
ADediting_963591	chr21_44224679_-	UTR3
ADediting_963592	chr21_44224684_-	UTR3
ADediting_963593	chr21_44224688_-	UTR3
ADediting_963594	chr21_44225222_-	UTR3
ADediting_1569136	chr21_44224281_-	UTR3
ADediting_1569137	chr21_44224295_-	UTR3
ADediting_1569138	chr21_44224303_-	UTR3
ADediting_1569139	chr21_44224429_-	UTR3
ADediting_1569140	chr21_44224461_-	UTR3
ADediting_1569141	chr21_44224482_-	UTR3
ADediting_1569142	chr21_44224664_-	UTR3
ADediting_1569143	chr21_44232657_-	intronic
ADediting_1569144	chr21_44232673_-	intronic

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_963555	chr21_44223827_-	SINE	Alu	Name=AluSg4
ADediting_963556	chr21_44223840_-	SINE	Alu	Name=AluSg4
ADediting_963557	chr21_44223864_-	SINE	Alu	Name=AluSg4
ADediting_963558	chr21_44223918_-	SINE	Alu	Name=AluSp
ADediting_963559	chr21_44223966_-	SINE	Alu	Name=AluSp
ADediting_963560	chr21_44223982_-	SINE	Alu	Name=AluSp
ADediting_963561	chr21_44223986_-	SINE	Alu	Name=AluSp
ADediting_963562	chr21_44224294_-	SINE	Alu	Name=AluSg4
ADediting_963563	chr21_44224447_-	SINE	Alu	Name=AluSz
ADediting_963564	chr21_44224459_-	SINE	Alu	Name=AluSz
ADediting_963565	chr21_44224460_-	SINE	Alu	Name=AluSz
ADediting_963566	chr21_44224474_-	SINE	Alu	Name=AluSz
ADediting_963567	chr21_44224485_-	SINE	Alu	Name=AluSz
ADediting_963568	chr21_44224486_-	SINE	Alu	Name=AluSz
ADediting_963569	chr21_44224487_-	SINE	Alu	Name=AluSz
ADediting_963570	chr21_44224500_-	SINE	Alu	Name=AluSz
ADediting_963571	chr21_44224501_-	SINE	Alu	Name=AluSz
ADediting_963572	chr21_44224512_-	SINE	Alu	Name=AluSz
ADediting_963573	chr21_44224521_-	SINE	Alu	Name=AluSz
ADediting_963574	chr21_44224524_-	SINE	Alu	Name=AluSz
ADediting_963575	chr21_44224532_-	SINE	Alu	Name=AluSz
ADediting_963576	chr21_44224538_-	SINE	Alu	Name=AluSz
ADediting_963577	chr21_44224541_-	SINE	Alu	Name=AluSz
ADediting_963578	chr21_44224547_-	SINE	Alu	Name=AluSz
ADediting_963579	chr21_44224563_-	SINE	Alu	Name=AluSz
ADediting_963580	chr21_44224579_-	SINE	Alu	Name=AluSz
ADediting_963581	chr21_44224589_-	SINE	Alu	Name=AluSz
ADediting_963582	chr21_44224592_-	SINE	Alu	Name=AluSz
ADediting_963583	chr21_44224593_-	SINE	Alu	Name=AluSz
ADediting_963584	chr21_44224601_-	SINE	Alu	Name=AluSz
ADediting_963585	chr21_44224611_-	SINE	Alu	Name=AluSz
ADediting_963586	chr21_44224615_-	SINE	Alu	Name=AluSz
ADediting_963587	chr21_44224621_-	SINE	Alu	Name=AluSz
ADediting_963588	chr21_44224635_-	SINE	Alu	Name=AluSz
ADediting_963589	chr21_44224636_-	SINE	Alu	Name=AluSz
ADediting_963590	chr21_44224651_-	SINE	Alu	Name=AluSz
ADediting_963591	chr21_44224679_-	SINE	Alu	Name=AluSz
ADediting_963592	chr21_44224684_-	SINE	Alu	Name=AluSz
ADediting_963593	chr21_44224688_-	SINE	Alu	Name=AluSz
ADediting_1569136	chr21_44224281_-	SINE	Alu	Name=AluSg4
ADediting_1569137	chr21_44224295_-	SINE	Alu	Name=AluSg4
ADediting_1569138	chr21_44224303_-	SINE	Alu	Name=AluSg4
ADediting_1569139	chr21_44224429_-	SINE	Alu	Name=AluSz
ADediting_1569140	chr21_44224461_-	SINE	Alu	Name=AluSz
ADediting_1569141	chr21_44224482_-	SINE	Alu	Name=AluSz
ADediting_1569142	chr21_44224664_-	SINE	Alu	Name=AluSz
ADediting_1569143	chr21_44232657_-	SINE	Alu	Name=AluJo
ADediting_1569144	chr21_44232673_-	SINE	Alu	Name=AluJo

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RNA A-to-I editing events in the alternative splicing sites for ICOSLG

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

ADeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ICOSLG

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

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Protein coding region RNA A-to-I editings for ICOSLG

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ICOSLG

RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1569136	chr21_44224281_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-150-5p	chr21	44224277	44224283	7mer-m8	44224276	44224297	140	-15.8
ADediting_1569136	chr21_44224281_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-186-3p	chr21	44224278	44224285	8mer-1a	44224278	44224302	141	-19.75
ADediting_1569136	chr21_44224281_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-520g-3p	chr21	44224281	44224287	7mer-m8	44224280	44224302	151	-15.87
ADediting_1569136	chr21_44224281_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-520h	chr21	44224281	44224287	7mer-m8	44224280	44224301	150	-15.08
ADediting_1569137	chr21_44224295_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-513a-5p	chr21	44224294	44224300	7mer-m8	44224293	44224310	152	-17.32
ADediting_1569137	chr21_44224295_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-638	chr21	44224289	44224295	7mer-1a	44224289	44224313	155	-34.17
ADediting_1569138	chr21_44224303_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-3622a-5p	chr21	44224298	44224304	7mer-m8	44224297	44224320	147	-30.07
ADediting_1569140	chr21_44224461_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6771-5p	chr21	44224459	44224466	8mer-1a	44224459	44224482	158	-28.65
ADediting_1569141	chr21_44224482_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6502-3p	chr21	44224479	44224485	7mer-m8	44224478	44224501	146	-16.15
ADediting_1569142	chr21_44224664_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-125a-3p	chr21	44224664	44224670	7mer-m8	44224663	44224684	140	-18.88
ADediting_1569142	chr21_44224664_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4690-3p	chr21	44224659	44224665	7mer-m8	44224658	44224678	157	-19.89
ADediting_1569142	chr21_44224664_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4726-3p	chr21	44224662	44224668	7mer-m8	44224661	44224682	140	-17.13
ADediting_1569142	chr21_44224664_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-5685	chr21	44224659	44224665	7mer-m8	44224658	44224679	148	-20.13
ADediting_963557	chr21_44223864_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4258	chr21	44223862	44223868	7mer-m8	44223861	44223877	155	-26.11
ADediting_963557	chr21_44223864_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4707-3p	chr21	44223861	44223867	7mer-m8	44223860	44223883	149	-25.41
ADediting_963558	chr21_44223918_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-5007-5p	chr21	44223913	44223919	7mer-m8	44223912	44223933	153	-18.46
ADediting_963561	chr21_44223986_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-10400-3p	chr21	44223982	44223988	7mer-m8	44223981	44224002	141	-22.13
ADediting_963561	chr21_44223986_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4437	chr21	44223982	44223989	8mer-1a	44223982	44224002	146	-19.59
ADediting_963561	chr21_44223986_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4674	chr21	44223982	44223988	7mer-m8	44223981	44224001	147	-23.48
ADediting_963562	chr21_44224294_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-8052	chr21	44224289	44224295	7mer-1a	44224289	44224307	148	-29.06
ADediting_963564	chr21_44224459_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-3189-3p	chr21	44224458	44224464	7mer-m8	44224457	44224476	149	-21.76
ADediting_963564	chr21_44224459_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6813-3p	chr21	44224457	44224463	7mer-m8	44224456	44224476	140	-10.68
ADediting_963565	chr21_44224460_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-326	chr21	44224458	44224464	7mer-m8	44224457	44224476	140	-13.25
ADediting_963565	chr21_44224460_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-330-5p	chr21	44224458	44224464	7mer-m8	44224457	44224478	140	-21.07
ADediting_963565	chr21_44224460_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4314	chr21	44224459	44224465	7mer-m8	44224458	44224475	142	-20.06
ADediting_963565	chr21_44224460_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-514a-5p	chr21	44224457	44224463	7mer-m8	44224456	44224479	146	-18.63
ADediting_963566	chr21_44224474_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-7112-5p	chr21	44224474	44224480	7mer-m8	44224473	44224494	150	-18.92
ADediting_963568	chr21_44224486_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-12119	chr21	44224485	44224491	7mer-m8	44224484	44224505	154	-21.54
ADediting_963568	chr21_44224486_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-3200-5p	chr21	44224484	44224490	7mer-m8	44224483	44224506	141	-14.09
ADediting_963568	chr21_44224486_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-452-3p	chr21	44224482	44224488	7mer-m8	44224481	44224502	140	-11.83
ADediting_963568	chr21_44224486_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-7162-3p	chr21	44224485	44224492	8mer-1a	44224485	44224505	142	-17.81
ADediting_963569	chr21_44224487_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-1298-5p	chr21	44224482	44224488	7mer-m8	44224481	44224501	148	-16.83
ADediting_963570	chr21_44224500_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4294	chr21	44224495	44224501	7mer-m8	44224494	44224511	150	-18.29
ADediting_963573	chr21_44224521_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-433-5p	chr21	44224520	44224526	7mer-m8	44224519	44224542	167	-28.7
ADediting_963575	chr21_44224532_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-340-3p	chr21	44224531	44224537	7mer-m8	44224530	44224551	149	-17.74
ADediting_963575	chr21_44224532_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6827-3p	chr21	44224531	44224537	7mer-m8	44224530	44224550	153	-17.53
ADediting_963578	chr21_44224547_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-548ae-3p	chr21	44224541	44224547	7mer-1a	44224541	44224560	140	-13.66
ADediting_963578	chr21_44224547_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-548aj-3p	chr21	44224541	44224547	7mer-1a	44224541	44224560	140	-16.16
ADediting_963578	chr21_44224547_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-548aq-3p	chr21	44224541	44224547	7mer-1a	44224541	44224561	140	-15.63
ADediting_963578	chr21_44224547_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-548h-3p	chr21	44224541	44224547	7mer-1a	44224541	44224562	140	-17.53
ADediting_963578	chr21_44224547_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-548x-3p	chr21	44224541	44224547	7mer-1a	44224541	44224559	140	-16.16
ADediting_963578	chr21_44224547_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-548z	chr21	44224541	44224547	7mer-1a	44224541	44224562	140	-17.53
ADediting_963579	chr21_44224563_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-564	chr21	44224559	44224565	7mer-m8	44224558	44224575	158	-24.45
ADediting_963581	chr21_44224589_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-3614-5p	chr21	44224589	44224595	7mer-m8	44224588	44224611	152	-25.74
ADediting_963581	chr21_44224589_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4691-3p	chr21	44224585	44224591	7mer-m8	44224584	44224611	150	-26.62
ADediting_963583	chr21_44224593_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6771-5p	chr21	44224592	44224598	7mer-m8	44224591	44224610	160	-31.46
ADediting_963584	chr21_44224601_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6089	chr21	44224596	44224602	7mer-m8	44224595	44224618	160	-33.44
ADediting_963587	chr21_44224621_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4497	chr21	44224620	44224626	7mer-m8	44224619	44224634	149	-21.46
ADediting_963590	chr21_44224651_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4793-3p	chr21	44224651	44224657	7mer-m8	44224650	44224672	153	-20.11
ADediting_963590	chr21_44224651_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-873-3p	chr21	44224647	44224653	7mer-m8	44224646	44224667	140	-19.3
ADediting_963593	chr21_44224688_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-3136-3p	chr21	44224684	44224691	8mer-1a	44224684	44224705	140	-14.04
ADediting_963593	chr21_44224688_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-7155-3p	chr21	44224684	44224691	8mer-1a	44224684	44224702	146	-16.17
ADediting_963594	chr21_44225222_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-1972	chr21	44225217	44225223	7mer-m8	44225216	44225237	152	-29.08
ADediting_963594	chr21_44225222_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4717-5p	chr21	44225218	44225224	7mer-m8	44225217	44225240	165	-29.26

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1569137	chr21_44224295_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-10399-5p	chr21	44224293	44224299	7mer-m8	44224292	44224313	144	-11.88
ADediting_1569137	chr21_44224295_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-7151-3p	chr21	44224294	44224301	8mer-1a	44224294	44224310	146	-17.62
ADediting_1569138	chr21_44224303_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6807-5p	chr21	44224303	44224309	7mer-m8	44224302	44224323	145	-22.46
ADediting_1569139	chr21_44224429_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4466	chr21	44224427	44224433	7mer-m8	44224426	44224445	142	-21.63
ADediting_1569139	chr21_44224429_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-675-5p	chr21	44224427	44224433	7mer-m8	44224426	44224447	149	-25.02
ADediting_1569139	chr21_44224429_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-764	chr21	44224425	44224431	7mer-m8	44224424	44224448	149	-23.05
ADediting_1569140	chr21_44224461_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-3689a-3p	chr21	44224460	44224467	8mer-1a	44224460	44224480	148	-21.42
ADediting_1569140	chr21_44224461_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-3689b-3p	chr21	44224460	44224467	8mer-1a	44224460	44224480	148	-21.47
ADediting_1569140	chr21_44224461_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-3689c	chr21	44224460	44224467	8mer-1a	44224460	44224480	148	-21.47
ADediting_1569140	chr21_44224461_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6779-5p	chr21	44224460	44224467	8mer-1a	44224460	44224483	147	-22.57
ADediting_1569140	chr21_44224461_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6780a-5p	chr21	44224460	44224467	8mer-1a	44224460	44224484	143	-21.09
ADediting_1569140	chr21_44224461_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-887-5p	chr21	44224459	44224466	8mer-1a	44224459	44224479	140	-10.77
ADediting_1569141	chr21_44224482_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-1288-5p	chr21	44224478	44224484	7mer-m8	44224477	44224499	140	-13.79
ADediting_1569141	chr21_44224482_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-5694	chr21	44224479	44224485	7mer-m8	44224478	44224497	147	-17.98
ADediting_1569141	chr21_44224482_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-579-3p	chr21	44224482	44224488	7mer-m8	44224481	44224503	142	-7.23
ADediting_1569141	chr21_44224482_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-664b-3p	chr21	44224482	44224488	7mer-m8	44224481	44224502	140	-8.75
ADediting_1569142	chr21_44224664_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-3135a	chr21	44224661	44224667	7mer-m8	44224660	44224680	152	-20.59
ADediting_1569142	chr21_44224664_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6800-5p	chr21	44224664	44224670	7mer-m8	44224663	44224683	155	-22.46
ADediting_963555	chr21_44223827_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-1976	chr21	44223822	44223829	8mer-1a	44223822	44223842	153	-25.04
ADediting_963555	chr21_44223827_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6747-3p	chr21	44223824	44223831	8mer-1a	44223824	44223846	149	-23.42
ADediting_963556	chr21_44223840_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-1200	chr21	44223837	44223843	7mer-m8	44223836	44223855	142	-20.39
ADediting_963557	chr21_44223864_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4715-3p	chr21	44223864	44223870	7mer-m8	44223863	44223883	146	-17.7
ADediting_963557	chr21_44223864_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4722-3p	chr21	44223862	44223868	7mer-m8	44223861	44223882	144	-20.37
ADediting_963557	chr21_44223864_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4763-5p	chr21	44223861	44223867	7mer-m8	44223860	44223883	145	-29.23
ADediting_963557	chr21_44223864_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6720-3p	chr21	44223859	44223865	7mer-m8	44223858	44223879	145	-21.66
ADediting_963559	chr21_44223966_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-324-3p	chr21	44223962	44223968	7mer-m8	44223961	44223983	149	-24.91
ADediting_963560	chr21_44223982_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-1343-3p	chr21	44223979	44223985	7mer-m8	44223978	44224001	150	-25.44
ADediting_963560	chr21_44223982_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6742-3p	chr21	44223979	44223986	8mer-1a	44223979	44223998	145	-14.93
ADediting_963560	chr21_44223982_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6783-3p	chr21	44223979	44223985	7mer-m8	44223978	44223998	146	-18.44
ADediting_963561	chr21_44223986_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-498-5p	chr21	44223986	44223992	7mer-m8	44223985	44224007	142	-10.65
ADediting_963562	chr21_44224294_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-10399-5p	chr21	44224293	44224299	7mer-m8	44224292	44224313	144	-11.88
ADediting_963562	chr21_44224294_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-5089-5p	chr21	44224289	44224295	7mer-m8	44224288	44224307	146	-13.24
ADediting_963565	chr21_44224460_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-887-5p	chr21	44224459	44224466	8mer-1a	44224459	44224479	140	-10.77
ADediting_963566	chr21_44224474_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6134	chr21	44224470	44224476	7mer-m8	44224469	44224487	150	-19.15
ADediting_963566	chr21_44224474_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-654-5p	chr21	44224472	44224478	7mer-m8	44224471	44224489	152	-19.88
ADediting_963567	chr21_44224485_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-579-3p	chr21	44224482	44224488	7mer-m8	44224481	44224503	142	-7.23
ADediting_963567	chr21_44224485_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-664b-3p	chr21	44224482	44224488	7mer-m8	44224481	44224502	140	-8.75
ADediting_963568	chr21_44224486_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-579-3p	chr21	44224482	44224488	7mer-m8	44224481	44224503	142	-7.23
ADediting_963568	chr21_44224486_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-664b-3p	chr21	44224482	44224488	7mer-m8	44224481	44224502	140	-8.75
ADediting_963569	chr21_44224487_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-579-3p	chr21	44224482	44224488	7mer-m8	44224481	44224503	142	-7.23
ADediting_963569	chr21_44224487_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-664b-3p	chr21	44224482	44224488	7mer-m8	44224481	44224502	140	-8.75
ADediting_963570	chr21_44224500_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-510-3p	chr21	44224499	44224506	8mer-1a	44224499	44224519	145	-11.83
ADediting_963571	chr21_44224501_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-510-3p	chr21	44224499	44224506	8mer-1a	44224499	44224519	145	-11.83
ADediting_963572	chr21_44224512_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4293	chr21	44224508	44224514	7mer-m8	44224507	44224523	146	-21.19
ADediting_963575	chr21_44224532_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-10a-5p	chr21	44224528	44224534	7mer-m8	44224527	44224549	145	-13.67
ADediting_963575	chr21_44224532_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-10b-5p	chr21	44224528	44224534	7mer-m8	44224527	44224549	140	-13.05
ADediting_963575	chr21_44224532_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-339-5p	chr21	44224529	44224535	7mer-m8	44224528	44224552	151	-18.58
ADediting_963575	chr21_44224532_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4421	chr21	44224530	44224536	7mer-m8	44224529	44224550	154	-16.19
ADediting_963575	chr21_44224532_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-5699-3p	chr21	44224530	44224536	7mer-m8	44224529	44224550	153	-17.34
ADediting_963575	chr21_44224532_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6818-3p	chr21	44224532	44224538	7mer-m8	44224531	44224552	140	-13.21
ADediting_963576	chr21_44224538_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-593-3p	chr21	44224532	44224538	7mer-1a	44224532	44224550	140	-19.02
ADediting_963578	chr21_44224547_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4666a-3p	chr21	44224546	44224552	7mer-m8	44224545	44224569	146	-11.52
ADediting_963578	chr21_44224547_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-548c-3p	chr21	44224541	44224547	7mer-1a	44224541	44224561	140	-12.12
ADediting_963579	chr21_44224563_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-3622b-5p	chr21	44224559	44224565	7mer-m8	44224558	44224577	143	-17.47
ADediting_963579	chr21_44224563_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4253	chr21	44224557	44224564	8mer-1a	44224557	44224574	140	-15.62
ADediting_963581	chr21_44224589_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-5690	chr21	44224585	44224591	7mer-m8	44224584	44224604	145	-16.74
ADediting_963582	chr21_44224592_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-12126	chr21	44224589	44224596	8mer-1a	44224589	44224612	147	-13.98
ADediting_963582	chr21_44224592_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-887-5p	chr21	44224592	44224598	7mer-m8	44224591	44224612	145	-20.79
ADediting_963583	chr21_44224593_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-12126	chr21	44224589	44224596	8mer-1a	44224589	44224612	147	-13.98
ADediting_963583	chr21_44224593_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-30b-3p	chr21	44224592	44224599	8mer-1a	44224592	44224613	152	-15.38
ADediting_963583	chr21_44224593_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-3689a-3p	chr21	44224592	44224599	8mer-1a	44224592	44224612	147	-16.57
ADediting_963583	chr21_44224593_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-3689b-3p	chr21	44224592	44224599	8mer-1a	44224592	44224612	147	-16.57
ADediting_963583	chr21_44224593_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-3689c	chr21	44224592	44224599	8mer-1a	44224592	44224612	147	-16.57
ADediting_963583	chr21_44224593_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6779-5p	chr21	44224592	44224599	8mer-1a	44224592	44224616	148	-21.3
ADediting_963583	chr21_44224593_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6780a-5p	chr21	44224592	44224599	8mer-1a	44224592	44224615	147	-20.31
ADediting_963583	chr21_44224593_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-887-5p	chr21	44224592	44224598	7mer-m8	44224591	44224612	145	-20.79
ADediting_963584	chr21_44224601_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-3929	chr21	44224597	44224603	7mer-m8	44224596	44224619	152	-19.44
ADediting_963584	chr21_44224601_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4478	chr21	44224597	44224603	7mer-m8	44224596	44224613	149	-20.76
ADediting_963584	chr21_44224601_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-4649-3p	chr21	44224600	44224606	7mer-m8	44224599	44224619	140	-13.39
ADediting_963584	chr21_44224601_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-485-5p	chr21	44224596	44224602	7mer-m8	44224595	44224617	147	-15.79
ADediting_963584	chr21_44224601_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-7160-5p	chr21	44224599	44224605	7mer-m8	44224598	44224617	148	-18.91
ADediting_963585	chr21_44224611_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-219b-3p	chr21	44224608	44224614	7mer-m8	44224607	44224633	145	-18.47
ADediting_963585	chr21_44224611_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-302f	chr21	44224609	44224615	7mer-m8	44224608	44224624	145	-7.47
ADediting_963587	chr21_44224621_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-6771-5p	chr21	44224620	44224627	8mer-1a	44224620	44224642	151	-20.74
ADediting_963589	chr21_44224636_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-106a-3p	chr21	44224635	44224642	8mer-1a	44224635	44224654	147	-10.51
ADediting_963590	chr21_44224651_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-32-5p	chr21	44224650	44224656	7mer-m8	44224649	44224671	155	-11.87
ADediting_963590	chr21_44224651_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-363-3p	chr21	44224650	44224656	7mer-m8	44224649	44224670	147	-14.38
ADediting_963590	chr21_44224651_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-5186	chr21	44224647	44224653	7mer-m8	44224646	44224666	140	-14.44
ADediting_963590	chr21_44224651_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-92a-3p	chr21	44224650	44224656	7mer-m8	44224649	44224666	155	-22.79
ADediting_963590	chr21_44224651_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-92b-3p	chr21	44224650	44224656	7mer-m8	44224649	44224666	155	-21.59
ADediting_963592	chr21_44224684_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-149-5p	chr21	44224682	44224689	8mer-1a	44224682	44224704	140	-16
ADediting_963592	chr21_44224684_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-514a-5p	chr21	44224679	44224686	8mer-1a	44224679	44224702	148	-14.68
ADediting_963593	chr21_44224688_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-149-5p	chr21	44224682	44224689	8mer-1a	44224682	44224704	140	-16
ADediting_963593	chr21_44224688_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-371b-5p	chr21	44224687	44224693	7mer-m8	44224686	44224707	146	-7.78
ADediting_963593	chr21_44224688_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-373-5p	chr21	44224687	44224693	7mer-m8	44224686	44224707	140	-8.34
ADediting_963593	chr21_44224688_-	ENSG00000160223.17	ENST00000407780.7	ICOSLG-204	hsa-miR-616-5p	chr21	44224687	44224693	7mer-m8	44224686	44224707	140	-6.79

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_1337758

chr7_5495892_-

ENSG00000160223.17

ENST00000400377.3

ICOSLG-202

hsa-miR-589-5p

chr21

44227896

44227902

7mer-m8

44227895

44227915

149

-19.32

ADediting_1337758

chr7_5495892_-

ENSG00000160223.17

ENST00000400379.7

ICOSLG-203

hsa-miR-589-5p

chr21

44227896

44227902

7mer-m8

44227895

44227915

149

-19.32

ADediting_1337758

chr7_5495892_-

ENSG00000160223.17

ENST00000400379.7

ICOSLG-203

hsa-miR-589-5p

chr21

44229362

44229368

7mer-m8

44229361

44229382

161

-20.9

ADediting_1337758

chr7_5495892_-

ENSG00000160223.17

ENST00000407780.7

ICOSLG-204

hsa-miR-589-5p

chr21

44227896

44227902

7mer-m8

44227895

44227915

149

-19.32

ADediting_1535954

chr14_101045974_+

ENSG00000160223.17

ENST00000407780.7

ICOSLG-204

hsa-miR-381-3p

chr21

44226826

44226832

7mer-m8

44226825

44226848

146

-13.57

ADediting_1631458

chr19_40282624_-

ENSG00000160223.17

ENST00000407780.7

ICOSLG-204

hsa-miR-641

chr21

44225504

44225510

7mer-m8

44225503

44225524

148

-18.17

ADediting_291761

chr11_93733708_-

ENSG00000160223.17

ENST00000400377.3

ICOSLG-202

hsa-miR-1304-3p

chr21

44228260

44228267

8mer-1a

44228260

44228283

159

-31.73

ADediting_291761

chr11_93733708_-

ENSG00000160223.17

ENST00000400379.7

ICOSLG-203

hsa-miR-1304-3p

chr21

44228260

44228267

8mer-1a

44228260

44228283

159

-31.73

ADediting_291761

chr11_93733708_-

ENSG00000160223.17

ENST00000407780.7

ICOSLG-204

hsa-miR-1304-3p

chr21

44228260

44228267

8mer-1a

44228260

44228283

159

-31.73

ADediting_496066

chr15_66496985_-

ENSG00000160223.17

ENST00000407780.7

ICOSLG-204

hsa-miR-4512

chr21

44224853

44224860

8mer-1a

44224853

44224874

149

-21.16

ADediting_496066

chr15_66496985_-

ENSG00000160223.17

ENST00000407780.7

ICOSLG-204

hsa-miR-4512

chr21

44226582

44226588

7mer-m8

44226581

44226601

159

-29.88

ADediting_98288

chr1_32086990_+

ENSG00000160223.17

ENST00000407780.7

ICOSLG-204

hsa-miR-5585-3p

chr21

44223221

44223227

7mer-m8

44223220

44223241

145

-20.33

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_107020

chr1_37500952_-

ENSG00000160223.17

ENST00000400377.3

ICOSLG-202

hsa-miR-5581-3p

chr21

44228163

44228169

7mer-m8

44228162

44228182

154

-20.77

ADediting_107020

chr1_37500952_-

ENSG00000160223.17

ENST00000400377.3

ICOSLG-202

hsa-miR-5581-3p

chr21

44228954

44228960

7mer-m8

44228953

44228973

141

-15.11

ADediting_107020

chr1_37500952_-

ENSG00000160223.17

ENST00000400379.7

ICOSLG-203

hsa-miR-5581-3p

chr21

44228163

44228169

7mer-m8

44228162

44228182

154

-20.77

ADediting_107020

chr1_37500952_-

ENSG00000160223.17

ENST00000400379.7

ICOSLG-203

hsa-miR-5581-3p

chr21

44228954

44228960

7mer-m8

44228953

44228973

141

-15.11

ADediting_107020

chr1_37500952_-

ENSG00000160223.17

ENST00000407780.7

ICOSLG-204

hsa-miR-5581-3p

chr21

44228163

44228169

7mer-m8

44228162

44228182

154

-20.77

ADediting_107020

chr1_37500952_-

ENSG00000160223.17

ENST00000407780.7

ICOSLG-204

hsa-miR-5581-3p

chr21

44228954

44228960

7mer-m8

44228953

44228973

141

-15.11

ADediting_1097295

chr3_85385762_+

ENSG00000160223.17

ENST00000407780.7

ICOSLG-204

hsa-miR-5688

chr21

44225115

44225121

7mer-m8

44225114

44225136

145

-7.83

ADediting_1337758

chr7_5495892_-

ENSG00000160223.17

ENST00000407780.7

ICOSLG-204

hsa-miR-589-5p

chr21

44223234

44223240

7mer-m8

44223233

44223255

154

-18.27

ADediting_1643790

chr3_121049689_+

ENSG00000160223.17

ENST00000407780.7

ICOSLG-204

hsa-miR-5682

chr21

44223225

44223231

7mer-m8

44223224

44223244

151

-24.32

ADediting_496066

chr15_66496985_-

ENSG00000160223.17

ENST00000407780.7

ICOSLG-204

hsa-miR-4512

chr21

44225840

44225846

7mer-m8

44225839

44225862

141

-21.78

ADediting_527135

chr16_24203190_+

ENSG00000160223.17

ENST00000407780.7

ICOSLG-204

hsa-miR-1273h-3p

chr21

44223126

44223132

7mer-m8

44223125

44223145

141

-19.05

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ICOSLG

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000407780.7	protein_coding

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_963555	ENST00000407780.7	chr21_44223827_-	6244	-3150.20	-3149.70	-3207.70
ADediting_963556	ENST00000407780.7	chr21_44223840_-	6231	-3149.00	-3149.70	-3207.70
ADediting_963557	ENST00000407780.7	chr21_44223864_-	6207	-3149.70	-3149.70	-3207.70
ADediting_963558	ENST00000407780.7	chr21_44223918_-	6153	-3150.90	-3149.70	-3207.70
ADediting_963559	ENST00000407780.7	chr21_44223966_-	6105	-3148.90	-3149.70	-3207.70
ADediting_963560	ENST00000407780.7	chr21_44223982_-	6089	-3149.60	-3149.70	-3207.70
ADediting_963561	ENST00000407780.7	chr21_44223986_-	6085	-3150.50	-3149.70	-3207.70
ADediting_1569136	ENST00000407780.7	chr21_44224281_-	5790	-3152.30	-3149.70	-3207.70
ADediting_963562	ENST00000407780.7	chr21_44224294_-	5777	-3149.90	-3149.70	-3207.70
ADediting_1569137	ENST00000407780.7	chr21_44224295_-	5776	-3154.20	-3149.70	-3207.70
ADediting_1569138	ENST00000407780.7	chr21_44224303_-	5768	-3153.90	-3149.70	-3207.70
ADediting_1569139	ENST00000407780.7	chr21_44224429_-	5642	-3154.50	-3149.70	-3207.70
ADediting_963563	ENST00000407780.7	chr21_44224447_-	5624	-3149.70	-3149.70	-3207.70
ADediting_963564	ENST00000407780.7	chr21_44224459_-	5612	-3149.40	-3149.70	-3207.70
ADediting_963565	ENST00000407780.7	chr21_44224460_-	5611	-3149.80	-3149.70	-3207.70
ADediting_1569140	ENST00000407780.7	chr21_44224461_-	5610	-3149.40	-3149.70	-3207.70
ADediting_963566	ENST00000407780.7	chr21_44224474_-	5597	-3149.30	-3149.70	-3207.70
ADediting_1569141	ENST00000407780.7	chr21_44224482_-	5589	-3149.10	-3149.70	-3207.70
ADediting_963567	ENST00000407780.7	chr21_44224485_-	5586	-3153.10	-3149.70	-3207.70
ADediting_963568	ENST00000407780.7	chr21_44224486_-	5585	-3153.00	-3149.70	-3207.70
ADediting_963569	ENST00000407780.7	chr21_44224487_-	5584	-3148.60	-3149.70	-3207.70
ADediting_963570	ENST00000407780.7	chr21_44224500_-	5571	-3149.70	-3149.70	-3207.70
ADediting_963571	ENST00000407780.7	chr21_44224501_-	5570	-3152.80	-3149.70	-3207.70
ADediting_963572	ENST00000407780.7	chr21_44224512_-	5559	-3149.00	-3149.70	-3207.70
ADediting_963573	ENST00000407780.7	chr21_44224521_-	5550	-3149.30	-3149.70	-3207.70
ADediting_963574	ENST00000407780.7	chr21_44224524_-	5547	-3150.70	-3149.70	-3207.70
ADediting_963575	ENST00000407780.7	chr21_44224532_-	5539	-3153.50	-3149.70	-3207.70
ADediting_963576	ENST00000407780.7	chr21_44224538_-	5533	-3149.40	-3149.70	-3207.70
ADediting_963577	ENST00000407780.7	chr21_44224541_-	5530	-3149.40	-3149.70	-3207.70
ADediting_963578	ENST00000407780.7	chr21_44224547_-	5524	-3149.70	-3149.70	-3207.70
ADediting_963579	ENST00000407780.7	chr21_44224563_-	5508	-3149.70	-3149.70	-3207.70
ADediting_963580	ENST00000407780.7	chr21_44224579_-	5492	-3149.70	-3149.70	-3207.70
ADediting_963581	ENST00000407780.7	chr21_44224589_-	5482	-3149.40	-3149.70	-3207.70
ADediting_963582	ENST00000407780.7	chr21_44224592_-	5479	-3149.60	-3149.70	-3207.70
ADediting_963583	ENST00000407780.7	chr21_44224593_-	5478	-3155.70	-3149.70	-3207.70
ADediting_963584	ENST00000407780.7	chr21_44224601_-	5470	-3149.00	-3149.70	-3207.70
ADediting_963585	ENST00000407780.7	chr21_44224611_-	5460	-3149.70	-3149.70	-3207.70
ADediting_963586	ENST00000407780.7	chr21_44224615_-	5456	-3149.40	-3149.70	-3207.70
ADediting_963587	ENST00000407780.7	chr21_44224621_-	5450	-3154.00	-3149.70	-3207.70
ADediting_963588	ENST00000407780.7	chr21_44224635_-	5436	-3149.90	-3149.70	-3207.70
ADediting_963589	ENST00000407780.7	chr21_44224636_-	5435	-3155.70	-3149.70	-3207.70
ADediting_963590	ENST00000407780.7	chr21_44224651_-	5420	-3149.70	-3149.70	-3207.70
ADediting_1569142	ENST00000407780.7	chr21_44224664_-	5407	-3148.40	-3149.70	-3207.70
ADediting_963591	ENST00000407780.7	chr21_44224679_-	5392	-3151.10	-3149.70	-3207.70
ADediting_963592	ENST00000407780.7	chr21_44224684_-	5387	-3155.90	-3149.70	-3207.70
ADediting_963593	ENST00000407780.7	chr21_44224688_-	5383	-3148.80	-3149.70	-3207.70
ADediting_963594	ENST00000407780.7	chr21_44225222_-	4849	-3155.60	-3149.70	-3207.70

RNA A-to-I editing in lncRNA.

ADeditom_ID

ENST

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for ICOSLG

Correlation between ADAR gene expression and RNA editing frequency

Tissue

ADeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	3.93850795234276e-14	0.41198712072667	1.89175206505205e-05	0.240335122625919	1.410768583478e-38	0.649815130142593
AC	8.28586584995385e-39	0.704522932650689	3.59592708817169e-19	0.525751266227029	3.97173667471098e-20	0.537617645204744
TCX	0.00108705764601528	0.264200998740061	0.0298019098147041	-0.177475186814283	1.10525554216833e-14	0.576903180359719
FP	0.00874582186521234	0.195985937429371	0.592212856296163	-0.0404156513464723	2.78557509579948e-12	0.492831523755283
PG	0.779518538943193	-0.0206637832117782	0.0347811081556748	-0.154887380202714	4.20422894756014e-11	0.45947096644142
STG	0.00321281938826342	0.317880710340535	0.712517604917994	-0.0407987106868438	1.30609642862965e-06	0.49967086555399

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Relation with AD stages for ICOSLG

Correlation between AD stages and RNA editing frequency

Tissue

ADeditomID

position

P-val

Coeff.

Correlation between AD stages and this gene's expression

Tissue

P-val

Coeff.

Top

RelatedDrugs for ICOSLG

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for ICOSLG

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
ICOSLG	C0007570	Celiac Disease	1	CTD_human
ICOSLG	C0009324	Ulcerative Colitis	1	CTD_human

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Gene summary for ICOSLG

RNA A-to-I events for ICOSLG

RNA editing positional annotations for ICOSLG using Annovar

RNA A-to-I editing events in the alternative splicing sites for ICOSLG

Differntial gene expression between RNA A-to-I edited versus non-edited samples for ICOSLG

Protein coding region RNA A-to-I editings for ICOSLG

The effects of the RNA editing to the miRNA binding sites for ICOSLG

The effects of the RNA editing to the stability of the RNA structures for ICOSLG

Relation with ADAR for ICOSLG

Relation with AD stages for ICOSLG

RelatedDrugs for ICOSLG

RelatedDiseases for ICOSLG

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene