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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for ICOSLG |
 Gene summary |
| Gene information | Gene symbol | ICOSLG | Gene ID | 23308 |
| Gene name | inducible T cell costimulator ligand | |
| Synonyms | B7-H2|B7H2|B7RP-1|B7RP1|B7h|CD275|GL50|ICOS-L|ICOSL|LICOS | |
| Cytomap | 21q22.3 | |
| Type of gene | protein-coding | |
| Description | ICOS ligandB7 homolog 2B7 homologue 2B7-like protein Gl50B7-related protein 1transmembrane protein B7-H2 ICOS ligand | |
| Modification date | 20200313 | |
| UniProtAcc | O75144, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for ICOSLG |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_963555(44223827, -), ADediting_963556(44223840, -), ADediting_963557(44223864, -), ADediting_963558(44223918, -), ADediting_963559(44223966, -), ADediting_963560(44223982, -), ADediting_963561(44223986, -), ADediting_963562(44224294, -), ADediting_963563(44224447, -), ADediting_963564(44224459, -), ADediting_963565(44224460, -), ADediting_963566(44224474, -), ADediting_963567(44224485, -), ADediting_963568(44224486, -), ADediting_963569(44224487, -), ADediting_963570(44224500, -), ADediting_963571(44224501, -), ADediting_963572(44224512, -), ADediting_963573(44224521, -), ADediting_963574(44224524, -), ADediting_963575(44224532, -), ADediting_963576(44224538, -), ADediting_963577(44224541, -), ADediting_963578(44224547, -), ADediting_963579(44224563, -), ADediting_963580(44224579, -), ADediting_963581(44224589, -), ADediting_963582(44224592, -), ADediting_963583(44224593, -), ADediting_963584(44224601, -), ADediting_963585(44224611, -), ADediting_963586(44224615, -), ADediting_963587(44224621, -), ADediting_963588(44224635, -), ADediting_963589(44224636, -), ADediting_963590(44224651, -), ADediting_963591(44224679, -), ADediting_963592(44224684, -), ADediting_963593(44224688, -), ADediting_963594(44225222, -), ADediting_1569136(44224281, -), ADediting_1569137(44224295, -), ADediting_1569138(44224303, -), ADediting_1569139(44224429, -), ADediting_1569140(44224461, -), ADediting_1569141(44224482, -), ADediting_1569142(44224664, -), ADediting_1569143(44232657, -), ADediting_1569144(44232673, -), |
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RNA editing positional annotations for ICOSLG using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_963555 | chr21_44223827_- | UTR3 |
| ADediting_963556 | chr21_44223840_- | UTR3 |
| ADediting_963557 | chr21_44223864_- | UTR3 |
| ADediting_963558 | chr21_44223918_- | UTR3 |
| ADediting_963559 | chr21_44223966_- | UTR3 |
| ADediting_963560 | chr21_44223982_- | UTR3 |
| ADediting_963561 | chr21_44223986_- | UTR3 |
| ADediting_963562 | chr21_44224294_- | UTR3 |
| ADediting_963563 | chr21_44224447_- | UTR3 |
| ADediting_963564 | chr21_44224459_- | UTR3 |
| ADediting_963565 | chr21_44224460_- | UTR3 |
| ADediting_963566 | chr21_44224474_- | UTR3 |
| ADediting_963567 | chr21_44224485_- | UTR3 |
| ADediting_963568 | chr21_44224486_- | UTR3 |
| ADediting_963569 | chr21_44224487_- | UTR3 |
| ADediting_963570 | chr21_44224500_- | UTR3 |
| ADediting_963571 | chr21_44224501_- | UTR3 |
| ADediting_963572 | chr21_44224512_- | UTR3 |
| ADediting_963573 | chr21_44224521_- | UTR3 |
| ADediting_963574 | chr21_44224524_- | UTR3 |
| ADediting_963575 | chr21_44224532_- | UTR3 |
| ADediting_963576 | chr21_44224538_- | UTR3 |
| ADediting_963577 | chr21_44224541_- | UTR3 |
| ADediting_963578 | chr21_44224547_- | UTR3 |
| ADediting_963579 | chr21_44224563_- | UTR3 |
| ADediting_963580 | chr21_44224579_- | UTR3 |
| ADediting_963581 | chr21_44224589_- | UTR3 |
| ADediting_963582 | chr21_44224592_- | UTR3 |
| ADediting_963583 | chr21_44224593_- | UTR3 |
| ADediting_963584 | chr21_44224601_- | UTR3 |
| ADediting_963585 | chr21_44224611_- | UTR3 |
| ADediting_963586 | chr21_44224615_- | UTR3 |
| ADediting_963587 | chr21_44224621_- | UTR3 |
| ADediting_963588 | chr21_44224635_- | UTR3 |
| ADediting_963589 | chr21_44224636_- | UTR3 |
| ADediting_963590 | chr21_44224651_- | UTR3 |
| ADediting_963591 | chr21_44224679_- | UTR3 |
| ADediting_963592 | chr21_44224684_- | UTR3 |
| ADediting_963593 | chr21_44224688_- | UTR3 |
| ADediting_963594 | chr21_44225222_- | UTR3 |
| ADediting_1569136 | chr21_44224281_- | UTR3 |
| ADediting_1569137 | chr21_44224295_- | UTR3 |
| ADediting_1569138 | chr21_44224303_- | UTR3 |
| ADediting_1569139 | chr21_44224429_- | UTR3 |
| ADediting_1569140 | chr21_44224461_- | UTR3 |
| ADediting_1569141 | chr21_44224482_- | UTR3 |
| ADediting_1569142 | chr21_44224664_- | UTR3 |
| ADediting_1569143 | chr21_44232657_- | intronic |
| ADediting_1569144 | chr21_44232673_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_963555 | chr21_44223827_- | SINE | Alu | Name=AluSg4 |
| ADediting_963556 | chr21_44223840_- | SINE | Alu | Name=AluSg4 |
| ADediting_963557 | chr21_44223864_- | SINE | Alu | Name=AluSg4 |
| ADediting_963558 | chr21_44223918_- | SINE | Alu | Name=AluSp |
| ADediting_963559 | chr21_44223966_- | SINE | Alu | Name=AluSp |
| ADediting_963560 | chr21_44223982_- | SINE | Alu | Name=AluSp |
| ADediting_963561 | chr21_44223986_- | SINE | Alu | Name=AluSp |
| ADediting_963562 | chr21_44224294_- | SINE | Alu | Name=AluSg4 |
| ADediting_963563 | chr21_44224447_- | SINE | Alu | Name=AluSz |
| ADediting_963564 | chr21_44224459_- | SINE | Alu | Name=AluSz |
| ADediting_963565 | chr21_44224460_- | SINE | Alu | Name=AluSz |
| ADediting_963566 | chr21_44224474_- | SINE | Alu | Name=AluSz |
| ADediting_963567 | chr21_44224485_- | SINE | Alu | Name=AluSz |
| ADediting_963568 | chr21_44224486_- | SINE | Alu | Name=AluSz |
| ADediting_963569 | chr21_44224487_- | SINE | Alu | Name=AluSz |
| ADediting_963570 | chr21_44224500_- | SINE | Alu | Name=AluSz |
| ADediting_963571 | chr21_44224501_- | SINE | Alu | Name=AluSz |
| ADediting_963572 | chr21_44224512_- | SINE | Alu | Name=AluSz |
| ADediting_963573 | chr21_44224521_- | SINE | Alu | Name=AluSz |
| ADediting_963574 | chr21_44224524_- | SINE | Alu | Name=AluSz |
| ADediting_963575 | chr21_44224532_- | SINE | Alu | Name=AluSz |
| ADediting_963576 | chr21_44224538_- | SINE | Alu | Name=AluSz |
| ADediting_963577 | chr21_44224541_- | SINE | Alu | Name=AluSz |
| ADediting_963578 | chr21_44224547_- | SINE | Alu | Name=AluSz |
| ADediting_963579 | chr21_44224563_- | SINE | Alu | Name=AluSz |
| ADediting_963580 | chr21_44224579_- | SINE | Alu | Name=AluSz |
| ADediting_963581 | chr21_44224589_- | SINE | Alu | Name=AluSz |
| ADediting_963582 | chr21_44224592_- | SINE | Alu | Name=AluSz |
| ADediting_963583 | chr21_44224593_- | SINE | Alu | Name=AluSz |
| ADediting_963584 | chr21_44224601_- | SINE | Alu | Name=AluSz |
| ADediting_963585 | chr21_44224611_- | SINE | Alu | Name=AluSz |
| ADediting_963586 | chr21_44224615_- | SINE | Alu | Name=AluSz |
| ADediting_963587 | chr21_44224621_- | SINE | Alu | Name=AluSz |
| ADediting_963588 | chr21_44224635_- | SINE | Alu | Name=AluSz |
| ADediting_963589 | chr21_44224636_- | SINE | Alu | Name=AluSz |
| ADediting_963590 | chr21_44224651_- | SINE | Alu | Name=AluSz |
| ADediting_963591 | chr21_44224679_- | SINE | Alu | Name=AluSz |
| ADediting_963592 | chr21_44224684_- | SINE | Alu | Name=AluSz |
| ADediting_963593 | chr21_44224688_- | SINE | Alu | Name=AluSz |
| ADediting_1569136 | chr21_44224281_- | SINE | Alu | Name=AluSg4 |
| ADediting_1569137 | chr21_44224295_- | SINE | Alu | Name=AluSg4 |
| ADediting_1569138 | chr21_44224303_- | SINE | Alu | Name=AluSg4 |
| ADediting_1569139 | chr21_44224429_- | SINE | Alu | Name=AluSz |
| ADediting_1569140 | chr21_44224461_- | SINE | Alu | Name=AluSz |
| ADediting_1569141 | chr21_44224482_- | SINE | Alu | Name=AluSz |
| ADediting_1569142 | chr21_44224664_- | SINE | Alu | Name=AluSz |
| ADediting_1569143 | chr21_44232657_- | SINE | Alu | Name=AluJo |
| ADediting_1569144 | chr21_44232673_- | SINE | Alu | Name=AluJo |
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RNA A-to-I editing events in the alternative splicing sites for ICOSLG |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ICOSLG |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |