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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for PACS2

check button Gene summary
Gene informationGene symbol

PACS2

Gene ID

23241

Gene namephosphofurin acidic cluster sorting protein 2
SynonymsEIEE66|PACS-2|PACS1L
Cytomap

14q32.33

Type of geneprotein-coding
Descriptionphosphofurin acidic cluster sorting protein 2PACS1-like protein
Modification date20200313
UniProtAcc

Q86VP3,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
PACS2

GO:0000045

autophagosome assembly

23455425

PACS2

GO:0034497

protein localization to phagophore assembly site

23455425


Top

RNA A-to-I events for PACS2

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_417940(105320047, +), ADediting_417941(105320082, +), ADediting_417942(105320891, +), ADediting_417943(105320897, +), ADediting_417944(105320898, +), ADediting_417945(105320903, +), ADediting_417946(105320933, +), ADediting_417947(105320943, +), ADediting_417948(105320957, +), ADediting_417949(105321003, +), ADediting_417950(105321006, +), ADediting_417951(105321022, +), ADediting_417952(105321032, +), ADediting_417953(105321033, +), ADediting_417954(105321046, +), ADediting_417955(105321598, +), ADediting_417956(105321601, +), ADediting_417957(105321643, +), ADediting_417958(105339292, +), ADediting_417959(105339326, +), ADediting_417960(105339342, +), ADediting_417961(105339348, +), ADediting_417962(105339355, +), ADediting_417963(105339356, +), ADediting_417964(105339360, +), ADediting_417965(105339386, +), ADediting_417966(105339575, +), ADediting_417967(105339576, +), ADediting_417968(105339599, +), ADediting_417969(105339918, +), ADediting_417970(105339944, +), ADediting_417971(105339962, +), ADediting_417972(105339988, +), ADediting_417973(105340013, +), ADediting_417974(105340041, +), ADediting_417975(105340056, +), ADediting_417976(105342295, +), ADediting_417977(105342342, +), ADediting_417978(105342347, +), ADediting_417979(105342367, +), ADediting_417980(105342380, +), ADediting_417981(105342775, +), ADediting_417982(105342841, +), ADediting_417983(105342856, +), ADediting_417984(105343744, +), ADediting_417985(105343751, +), ADediting_417986(105343765, +), ADediting_417987(105343795, +), ADediting_417988(105343796, +), ADediting_417989(105344151, +), ADediting_417990(105344352, +), ADediting_417991(105344368, +), ADediting_417992(105345034, +), ADediting_417993(105345179, +), ADediting_417994(105345286, +), ADediting_417995(105353623, +), ADediting_417996(105353674, +), ADediting_417997(105359377, +), ADediting_417998(105359388, +), ADediting_417999(105359394, +), ADediting_418000(105359408, +), ADediting_418001(105359447, +), ADediting_418002(105359497, +), ADediting_418003(105359543, +), ADediting_418004(105359655, +), ADediting_418005(105359661, +), ADediting_418006(105360285, +), ADediting_418007(105360330, +), ADediting_418008(105360340, +), ADediting_418009(105360341, +), ADediting_418010(105360353, +), ADediting_418011(105360379, +), ADediting_418012(105360397, +), ADediting_418013(105360417, +), ADediting_418014(105360423, +), ADediting_418015(105360424, +), ADediting_418016(105360429, +), ADediting_418017(105360433, +), ADediting_418018(105360436, +), ADediting_418019(105360464, +), ADediting_418020(105360498, +), ADediting_418021(105361530, +), ADediting_418022(105361842, +), ADediting_418023(105364797, +), ADediting_418024(105364800, +), ADediting_418025(105364809, +), ADediting_418026(105364941, +), ADediting_418027(105364950, +), ADediting_418028(105364966, +), ADediting_418029(105366094, +), ADediting_418030(105366095, +), ADediting_418031(105366100, +), ADediting_418032(105366183, +), ADediting_418033(105366227, +), ADediting_418034(105366245, +), ADediting_418035(105366298, +), ADediting_418036(105370441, +), ADediting_418037(105370457, +), ADediting_418038(105370458, +), ADediting_418039(105370463, +), ADediting_418040(105370479, +), ADediting_418041(105370480, +), ADediting_418042(105370488, +), ADediting_418043(105370506, +), ADediting_418044(105370593, +), ADediting_418045(105370619, +), ADediting_418046(105370711, +), ADediting_418047(105370727, +), ADediting_418048(105370795, +), ADediting_418049(105370799, +), ADediting_418050(105370821, +), ADediting_418051(105370822, +), ADediting_418052(105370834, +), ADediting_418053(105370843, +), ADediting_418054(105372653, +), ADediting_418055(105372781, +), ADediting_418056(105375218, +), ADediting_418057(105375224, +), ADediting_418058(105375225, +), ADediting_418059(105375269, +), ADediting_418060(105375276, +), ADediting_418061(105375277, +), ADediting_418062(105375291, +), ADediting_418063(105375357, +), ADediting_418064(105388569, +), ADediting_418065(105390566, +), ADediting_418066(105393646, +), ADediting_418067(105393659, +), ADediting_418068(105393664, +), ADediting_418069(105393683, +), ADediting_418070(105393690, +), ADediting_418071(105393958, +), ADediting_418072(105393959, +), ADediting_418073(105393972, +), ADediting_418074(105393983, +), ADediting_418075(105393988, +), ADediting_418076(105394026, +), ADediting_418077(105396601, +), ADediting_418078(105396746, +), ADediting_1536206(105320484, +), ADediting_1536207(105320486, +), ADediting_1536208(105320492, +), ADediting_1536209(105321475, +), ADediting_1536210(105321492, +), ADediting_1536211(105321502, +), ADediting_1536212(105321512, +), ADediting_1536213(105321520, +), ADediting_1536214(105340018, +), ADediting_1536215(105361441, +), ADediting_1536216(105370820, +), ADediting_1536217(105375026, +), ADediting_1536218(105393612, +), ADediting_1536219(105393950, +), ADediting_1618095(105320967, +),

Top

RNA editing positional annotations for PACS2 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_417940chr14_105320047_+intronic
ADediting_417941chr14_105320082_+intronic
ADediting_417942chr14_105320891_+intronic
ADediting_417943chr14_105320897_+intronic
ADediting_417944chr14_105320898_+intronic
ADediting_417945chr14_105320903_+intronic
ADediting_417946chr14_105320933_+intronic
ADediting_417947chr14_105320943_+intronic
ADediting_417948chr14_105320957_+intronic
ADediting_417949chr14_105321003_+intronic
ADediting_417950chr14_105321006_+intronic
ADediting_417951chr14_105321022_+intronic
ADediting_417952chr14_105321032_+intronic
ADediting_417953chr14_105321033_+intronic
ADediting_417954chr14_105321046_+intronic
ADediting_417955chr14_105321598_+intronic
ADediting_417956chr14_105321601_+intronic
ADediting_417957chr14_105321643_+intronic
ADediting_417958chr14_105339292_+intronic
ADediting_417959chr14_105339326_+intronic
ADediting_417960chr14_105339342_+intronic
ADediting_417961chr14_105339348_+intronic
ADediting_417962chr14_105339355_+intronic
ADediting_417963chr14_105339356_+intronic
ADediting_417964chr14_105339360_+intronic
ADediting_417965chr14_105339386_+intronic
ADediting_417966chr14_105339575_+intronic
ADediting_417967chr14_105339576_+intronic
ADediting_417968chr14_105339599_+intronic
ADediting_417969chr14_105339918_+intronic
ADediting_417970chr14_105339944_+intronic
ADediting_417971chr14_105339962_+intronic
ADediting_417972chr14_105339988_+intronic
ADediting_417973chr14_105340013_+intronic
ADediting_417974chr14_105340041_+intronic
ADediting_417975chr14_105340056_+intronic
ADediting_417976chr14_105342295_+intronic
ADediting_417977chr14_105342342_+intronic
ADediting_417978chr14_105342347_+intronic
ADediting_417979chr14_105342367_+intronic
ADediting_417980chr14_105342380_+intronic
ADediting_417981chr14_105342775_+intronic
ADediting_417982chr14_105342841_+intronic
ADediting_417983chr14_105342856_+intronic
ADediting_417984chr14_105343744_+intronic
ADediting_417985chr14_105343751_+intronic
ADediting_417986chr14_105343765_+intronic
ADediting_417987chr14_105343795_+intronic
ADediting_417988chr14_105343796_+intronic
ADediting_417989chr14_105344151_+intronic
ADediting_417990chr14_105344352_+intronic
ADediting_417991chr14_105344368_+intronic
ADediting_417992chr14_105345034_+intronic
ADediting_417993chr14_105345179_+intronic
ADediting_417994chr14_105345286_+intronic
ADediting_417995chr14_105353623_+intronic
ADediting_417996chr14_105353674_+intronic
ADediting_417997chr14_105359377_+intronic
ADediting_417998chr14_105359388_+intronic
ADediting_417999chr14_105359394_+intronic
ADediting_418000chr14_105359408_+intronic
ADediting_418001chr14_105359447_+intronic
ADediting_418002chr14_105359497_+intronic
ADediting_418003chr14_105359543_+intronic
ADediting_418004chr14_105359655_+intronic
ADediting_418005chr14_105359661_+intronic
ADediting_418006chr14_105360285_+intronic
ADediting_418007chr14_105360330_+intronic
ADediting_418008chr14_105360340_+intronic
ADediting_418009chr14_105360341_+intronic
ADediting_418010chr14_105360353_+intronic
ADediting_418011chr14_105360379_+intronic
ADediting_418012chr14_105360397_+intronic
ADediting_418013chr14_105360417_+intronic
ADediting_418014chr14_105360423_+intronic
ADediting_418015chr14_105360424_+intronic
ADediting_418016chr14_105360429_+intronic
ADediting_418017chr14_105360433_+intronic
ADediting_418018chr14_105360436_+intronic
ADediting_418019chr14_105360464_+intronic
ADediting_418020chr14_105360498_+intronic
ADediting_418021chr14_105361530_+intronic
ADediting_418022chr14_105361842_+intronic
ADediting_418023chr14_105364797_+intronic
ADediting_418024chr14_105364800_+intronic
ADediting_418025chr14_105364809_+intronic
ADediting_418026chr14_105364941_+intronic
ADediting_418027chr14_105364950_+intronic
ADediting_418028chr14_105364966_+intronic
ADediting_418029chr14_105366094_+intronic
ADediting_418030chr14_105366095_+intronic
ADediting_418031chr14_105366100_+intronic
ADediting_418032chr14_105366183_+intronic
ADediting_418033chr14_105366227_+intronic
ADediting_418034chr14_105366245_+intronic
ADediting_418035chr14_105366298_+intronic
ADediting_418036chr14_105370441_+ncRNA_exonic
ADediting_418037chr14_105370457_+ncRNA_exonic
ADediting_418038chr14_105370458_+ncRNA_exonic
ADediting_418039chr14_105370463_+ncRNA_exonic
ADediting_418040chr14_105370479_+ncRNA_exonic
ADediting_418041chr14_105370480_+ncRNA_exonic
ADediting_418042chr14_105370488_+ncRNA_exonic
ADediting_418043chr14_105370506_+ncRNA_exonic
ADediting_418044chr14_105370593_+ncRNA_exonic
ADediting_418045chr14_105370619_+ncRNA_exonic
ADediting_418046chr14_105370711_+ncRNA_exonic
ADediting_418047chr14_105370727_+ncRNA_exonic
ADediting_418048chr14_105370795_+ncRNA_exonic
ADediting_418049chr14_105370799_+ncRNA_exonic
ADediting_418050chr14_105370821_+ncRNA_exonic
ADediting_418051chr14_105370822_+ncRNA_exonic
ADediting_418052chr14_105370834_+ncRNA_exonic
ADediting_418053chr14_105370843_+ncRNA_exonic
ADediting_418054chr14_105372653_+ncRNA_exonic
ADediting_418055chr14_105372781_+ncRNA_exonic
ADediting_418056chr14_105375218_+intronic
ADediting_418057chr14_105375224_+intronic
ADediting_418058chr14_105375225_+intronic
ADediting_418059chr14_105375269_+intronic
ADediting_418060chr14_105375276_+intronic
ADediting_418061chr14_105375277_+intronic
ADediting_418062chr14_105375291_+intronic
ADediting_418063chr14_105375357_+intronic
ADediting_418064chr14_105388569_+intronic
ADediting_418065chr14_105390566_+intronic
ADediting_418066chr14_105393646_+intronic
ADediting_418067chr14_105393659_+intronic
ADediting_418068chr14_105393664_+intronic
ADediting_418069chr14_105393683_+intronic
ADediting_418070chr14_105393690_+intronic
ADediting_418071chr14_105393958_+intronic
ADediting_418072chr14_105393959_+intronic
ADediting_418073chr14_105393972_+intronic
ADediting_418074chr14_105393983_+intronic
ADediting_418075chr14_105393988_+intronic
ADediting_418076chr14_105394026_+intronic
ADediting_418077chr14_105396601_+UTR3
ADediting_418078chr14_105396746_+UTR3
ADediting_1536206chr14_105320484_+intronic
ADediting_1536207chr14_105320486_+intronic
ADediting_1536208chr14_105320492_+intronic
ADediting_1536209chr14_105321475_+intronic
ADediting_1536210chr14_105321492_+intronic
ADediting_1536211chr14_105321502_+intronic
ADediting_1536212chr14_105321512_+intronic
ADediting_1536213chr14_105321520_+intronic
ADediting_1536214chr14_105340018_+intronic
ADediting_1536215chr14_105361441_+intronic
ADediting_1536216chr14_105370820_+ncRNA_exonic
ADediting_1536217chr14_105375026_+intronic
ADediting_1536218chr14_105393612_+intronic
ADediting_1536219chr14_105393950_+intronic
ADediting_1618095chr14_105320967_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_417940chr14_105320047_+SINEAluName=AluSc
ADediting_417941chr14_105320082_+SINEAluName=AluSc
ADediting_417942chr14_105320891_+SINEAluName=AluSx
ADediting_417943chr14_105320897_+SINEAluName=AluSx
ADediting_417944chr14_105320898_+SINEAluName=AluSx
ADediting_417945chr14_105320903_+SINEAluName=AluSx
ADediting_417946chr14_105320933_+SINEAluName=AluSx
ADediting_417947chr14_105320943_+SINEAluName=AluSx
ADediting_417948chr14_105320957_+SINEAluName=AluSx
ADediting_417949chr14_105321003_+SINEAluName=AluSx
ADediting_417950chr14_105321006_+SINEAluName=AluSx
ADediting_417951chr14_105321022_+SINEAluName=AluSx
ADediting_417952chr14_105321032_+SINEAluName=AluSx
ADediting_417953chr14_105321033_+SINEAluName=AluSx
ADediting_417954chr14_105321046_+SINEAluName=AluSx
ADediting_417955chr14_105321598_+SINEAluName=AluJb
ADediting_417956chr14_105321601_+SINEAluName=AluJb
ADediting_417957chr14_105321643_+SINEAluName=AluJb
ADediting_417958chr14_105339292_+SINEAluName=AluSq2
ADediting_417959chr14_105339326_+SINEAluName=AluSq2
ADediting_417960chr14_105339342_+SINEAluName=AluSq2
ADediting_417961chr14_105339348_+SINEAluName=AluSq2
ADediting_417962chr14_105339355_+SINEAluName=AluSq2
ADediting_417963chr14_105339356_+SINEAluName=AluSq2
ADediting_417964chr14_105339360_+SINEAluName=AluSq2
ADediting_417965chr14_105339386_+SINEAluName=AluSq2
ADediting_417966chr14_105339575_+SINEAluName=AluJr
ADediting_417967chr14_105339576_+SINEAluName=AluJr
ADediting_417968chr14_105339599_+SINEAluName=AluJr
ADediting_417969chr14_105339918_+SINEAluName=AluJb
ADediting_417970chr14_105339944_+SINEAluName=AluJb
ADediting_417971chr14_105339962_+SINEAluName=AluJb
ADediting_417972chr14_105339988_+SINEAluName=AluJb
ADediting_417973chr14_105340013_+SINEAluName=AluJb
ADediting_417974chr14_105340041_+SINEAluName=AluJb
ADediting_417975chr14_105340056_+SINEAluName=AluJb
ADediting_417976chr14_105342295_+SINEAluName=AluJr
ADediting_417977chr14_105342342_+SINEAluName=AluJr
ADediting_417978chr14_105342347_+SINEAluName=AluJr
ADediting_417979chr14_105342367_+SINEAluName=AluJr
ADediting_417980chr14_105342380_+SINEAluName=AluJr
ADediting_417981chr14_105342775_+SINEAluName=AluSz
ADediting_417982chr14_105342841_+SINEAluName=AluSz
ADediting_417983chr14_105342856_+SINEAluName=AluSz
ADediting_417984chr14_105343744_+SINEAluName=AluSx3
ADediting_417985chr14_105343751_+SINEAluName=AluSx3
ADediting_417986chr14_105343765_+SINEAluName=AluSx3
ADediting_417987chr14_105343795_+SINEAluName=AluSx3
ADediting_417988chr14_105343796_+SINEAluName=AluSx3
ADediting_417989chr14_105344151_+SINEAluName=AluJo
ADediting_417990chr14_105344352_+SINEAluName=AluSx3
ADediting_417991chr14_105344368_+SINEAluName=AluSx3
ADediting_417992chr14_105345034_+SINEAluName=AluSx
ADediting_417993chr14_105345179_+SINEAluName=AluYm1
ADediting_417994chr14_105345286_+SINEAluName=AluYm1
ADediting_417995chr14_105353623_+SINEAluName=AluSg
ADediting_417996chr14_105353674_+SINEAluName=AluSg
ADediting_417997chr14_105359377_+SINEAluName=AluSq
ADediting_417998chr14_105359388_+SINEAluName=AluSq
ADediting_417999chr14_105359394_+SINEAluName=AluSq
ADediting_418000chr14_105359408_+SINEAluName=AluSq
ADediting_418001chr14_105359447_+SINEAluName=AluSq
ADediting_418002chr14_105359497_+SINEAluName=AluSq
ADediting_418003chr14_105359543_+SINEAluName=AluSq
ADediting_418004chr14_105359655_+SINEAluName=AluY
ADediting_418005chr14_105359661_+SINEAluName=AluY
ADediting_418006chr14_105360285_+SINEAluName=AluSx
ADediting_418007chr14_105360330_+SINEAluName=AluSx
ADediting_418008chr14_105360340_+SINEAluName=AluSx
ADediting_418009chr14_105360341_+SINEAluName=AluSx
ADediting_418010chr14_105360353_+SINEAluName=AluSx
ADediting_418011chr14_105360379_+SINEAluName=AluSx
ADediting_418012chr14_105360397_+SINEAluName=AluSx
ADediting_418013chr14_105360417_+SINEAluName=AluSx
ADediting_418014chr14_105360423_+SINEAluName=AluSx
ADediting_418015chr14_105360424_+SINEAluName=AluSx
ADediting_418016chr14_105360429_+SINEAluName=AluSx
ADediting_418017chr14_105360433_+SINEAluName=AluSx
ADediting_418018chr14_105360436_+SINEAluName=AluSx
ADediting_418019chr14_105360464_+SINEAluName=AluSx
ADediting_418020chr14_105360498_+SINEAluName=AluSx
ADediting_418021chr14_105361530_+SINEAluName=AluSq2
ADediting_418022chr14_105361842_+SINEAluName=AluSp
ADediting_418023chr14_105364797_+SINEAluName=AluJr
ADediting_418024chr14_105364800_+SINEAluName=AluJr
ADediting_418025chr14_105364809_+SINEAluName=AluJr
ADediting_418026chr14_105364941_+SINEAluName=AluJr
ADediting_418027chr14_105364950_+SINEAluName=AluJr
ADediting_418028chr14_105364966_+SINEAluName=AluJr
ADediting_418029chr14_105366094_+SINEAluName=AluSx1
ADediting_418030chr14_105366095_+SINEAluName=AluSx1
ADediting_418031chr14_105366100_+SINEAluName=AluSx1
ADediting_418032chr14_105366183_+SINEAluName=AluSx1
ADediting_418033chr14_105366227_+SINEAluName=AluSx1
ADediting_418034chr14_105366245_+SINEAluName=AluSx1
ADediting_418035chr14_105366298_+SINEAluName=AluSx1
ADediting_418036chr14_105370441_+SINEAluName=AluJb
ADediting_418037chr14_105370457_+SINEAluName=AluJb
ADediting_418038chr14_105370458_+SINEAluName=AluJb
ADediting_418039chr14_105370463_+SINEAluName=AluJb
ADediting_418040chr14_105370479_+SINEAluName=AluJb
ADediting_418041chr14_105370480_+SINEAluName=AluJb
ADediting_418042chr14_105370488_+SINEAluName=AluJb
ADediting_418043chr14_105370506_+SINEAluName=AluJb
ADediting_418044chr14_105370593_+SINEAluName=AluJb
ADediting_418045chr14_105370619_+SINEAluName=AluJb
ADediting_418046chr14_105370711_+SINEAluName=AluSx
ADediting_418047chr14_105370727_+SINEAluName=AluSx
ADediting_418048chr14_105370795_+SINEAluName=AluSx
ADediting_418049chr14_105370799_+SINEAluName=AluSx
ADediting_418050chr14_105370821_+SINEAluName=AluSx
ADediting_418051chr14_105370822_+SINEAluName=AluSx
ADediting_418052chr14_105370834_+SINEAluName=AluSx
ADediting_418053chr14_105370843_+SINEAluName=AluSx
ADediting_418054chr14_105372653_+SINEAluName=AluY
ADediting_418055chr14_105372781_+SINEAluName=AluY
ADediting_418056chr14_105375218_+SINEAluName=AluY
ADediting_418057chr14_105375224_+SINEAluName=AluY
ADediting_418058chr14_105375225_+SINEAluName=AluY
ADediting_418059chr14_105375269_+SINEAluName=AluY
ADediting_418060chr14_105375276_+SINEAluName=AluY
ADediting_418061chr14_105375277_+SINEAluName=AluY
ADediting_418062chr14_105375291_+SINEAluName=AluY
ADediting_418063chr14_105375357_+SINEAluName=AluY
ADediting_418066chr14_105393646_+SINEAluName=AluSq2
ADediting_418067chr14_105393659_+SINEAluName=AluSq2
ADediting_418068chr14_105393664_+SINEAluName=AluSq2
ADediting_418069chr14_105393683_+SINEAluName=AluSq2
ADediting_418070chr14_105393690_+SINEAluName=AluSq2
ADediting_418071chr14_105393958_+SINEAluName=AluYc
ADediting_418072chr14_105393959_+SINEAluName=AluYc
ADediting_418073chr14_105393972_+SINEAluName=AluYc
ADediting_418074chr14_105393983_+SINEAluName=AluYc
ADediting_418075chr14_105393988_+SINEAluName=AluYc
ADediting_418076chr14_105394026_+SINEAluName=AluYc
ADediting_418077chr14_105396601_+SINEAluName=AluSz
ADediting_418078chr14_105396746_+SINEAluName=AluSz
ADediting_1536206chr14_105320484_+SINEAluName=AluJr4
ADediting_1536207chr14_105320486_+SINEAluName=AluJr4
ADediting_1536208chr14_105320492_+SINEAluName=AluJr4
ADediting_1536209chr14_105321475_+SINEAluName=AluJb
ADediting_1536210chr14_105321492_+SINEAluName=AluJb
ADediting_1536211chr14_105321502_+SINEAluName=AluJb
ADediting_1536212chr14_105321512_+SINEAluName=AluJb
ADediting_1536213chr14_105321520_+SINEAluName=AluJb
ADediting_1536214chr14_105340018_+SINEAluName=AluJb
ADediting_1536215chr14_105361441_+SINEAluName=AluSq2
ADediting_1536216chr14_105370820_+SINEAluName=AluSx
ADediting_1536217chr14_105375026_+SINEAluName=FRAM
ADediting_1536218chr14_105393612_+SINEAluName=AluSq2
ADediting_1536219chr14_105393950_+SINEAluName=AluYc
ADediting_1618095chr14_105320967_+SINEAluName=AluSx

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RNA A-to-I editing events in the alternative splicing sites for PACS2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESADediting_1536218chr14_105393612_+105393594:1053936163ss2iTTTTTTTTTTTTTGAGACAGAGT3.01TTTTTTTTTTTTTGAGACGGAGT-4.95
ESADediting_1536218chr14_105393612_+105393594:1053936163ss2iTTTTTTTTTTTTTGAGACAGAGT3.01TTTTTTTTTTTTTGAGACGGAGT-4.95
ESADediting_418069chr14_105393683_+105393682:1053936905ss2eCAGGTTCAA1.19CGGGTTCAA-6.26
ESADediting_418069chr14_105393683_+105393682:1053936905ss2eCAGGTTCAA1.19CGGGTTCAA-6.26
ESADediting_418070chr14_105393690_+105393682:1053936905ss6iCAGGTTCAA1.19CAGGTTCAG2.78
ESADediting_418070chr14_105393690_+105393682:1053936905ss6iCAGGTTCAA1.19CAGGTTCAG2.78

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PACS2

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for PACS2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
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The effects of the RNA editing to the miRNA binding sites for PACS2

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
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check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_418078chr14_105396746_+ENSG00000179364.13ENST00000447393.5PACS2-203hsa-miR-4767chr141053967441053967507mer-m8105396727105396751143-18.04

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_418078chr14_105396746_+ENSG00000179364.13ENST00000447393.5PACS2-203hsa-miR-3165chr141053967411053967477mer-m8105396729105396748149-16.89
ADediting_418078chr14_105396746_+ENSG00000179364.13ENST00000447393.5PACS2-203hsa-miR-6745chr141053967421053967487mer-m8105396725105396749150-25.73

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337757chr7_5495852_-ENSG00000179364.13ENST00000325438.12PACS2-201hsa-miR-589-3pchr141053948521053948587mer-m8105394835105394859159-24.56
ADediting_1337757chr7_5495852_-ENSG00000179364.13ENST00000447393.5PACS2-203hsa-miR-589-3pchr141053948521053948587mer-m8105394835105394859159-24.56
ADediting_1337757chr7_5495852_-ENSG00000179364.13ENST00000447393.5PACS2-203hsa-miR-589-3pchr141053965301053965367mer-m8105396513105396537158-19.59
ADediting_1337757chr7_5495852_-ENSG00000179364.13ENST00000547217.5PACS2-205hsa-miR-589-3pchr141053948521053948587mer-m8105394835105394859159-24.56
ADediting_1337758chr7_5495892_-ENSG00000179364.13ENST00000325438.12PACS2-201hsa-miR-589-5pchr141053951641053951718mer-1a105395148105395171163-27.21
ADediting_1337758chr7_5495892_-ENSG00000179364.13ENST00000447393.5PACS2-203hsa-miR-589-5pchr141053951641053951718mer-1a105395148105395171163-27.21
ADediting_286380chr11_79422188_-ENSG00000179364.13ENST00000447393.5PACS2-203hsa-miR-5579-3pchr141053974591053974657mer-m8105397445105397466145-12.41

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337757chr7_5495852_-ENSG00000179364.13ENST00000447393.5PACS2-203hsa-miR-589-3pchr141053972581053972658mer-1a105397242105397265140-14.1

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PACS2

check button - RNA A-to-I editing in mRNA.
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ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000447393.5protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_418077ENST00000447393.5chr14_105396601_+4819-2760.70-2760.70-2761.00
ADediting_418078ENST00000447393.5chr14_105396746_+4964-2761.00-2760.70-2761.00

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for PACS2

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_418015chr14_105360424_+0.692782426056219-0.02252730252002850.0266158181099001-0.1259302123122311.48422561237595e-120.387631462179754
DLPFCADediting_418018chr14_105360436_+0.8623362161456220.009888221916767140.0301647755651338-0.1231579961476454.17969058085377e-150.426106088551419
DLPFCADediting_418020chr14_105360498_+0.554315214579619-0.03371057635572250.00676811433131628-0.1535139698684411.89262179143041e-160.444562742159103
TCXADediting_418045chr14_105370619_+0.7021155706428980.03148387022192730.325694833936878-0.08079170590200477.1501446666721e-050.318432038214133
TCXADediting_418056chr14_105375218_+0.909176858634787-0.009392706446574550.0330775364236241-0.1741319595661835.22920838422805e-050.324038325211669
CERADediting_418057chr14_105375224_+0.0001732050353674520.3019483386016236.9588360255086e-050.3189223961463440.3522691100815270.0764787363211917
CERADediting_418059chr14_105375269_+0.01308452088550630.2022044924595534.4141975324777e-050.3270290474084670.001504741919788840.256922135485035
TCXADediting_418059chr14_105375269_+0.5925142941381870.04404582200650550.361240666265132-0.07506916308880126.68638331105586e-050.319642989684091
TCXADediting_418062chr14_105375291_+0.04180607324408170.1664247855064660.340509199576415-0.07836093347534772.58702571641128e-050.336261781745927
TCXADediting_418063chr14_105375357_+0.1928279514906750.1069183387078450.129143479360652-0.1244612814313015.35483125201144e-050.323616789381823
TCXADediting_418067chr14_105393659_+0.257501506951223-0.09303082262712720.09221609016692-0.1379793444474031.05446135956259e-050.351138563590083
DLPFCADediting_418076chr14_105394026_+0.470418172442029-0.04114426842011080.0162899925600834-0.1363574308276985.86979235099049e-100.342477506394891

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC8.37222288352236e-140.4070874753007031.52652394978768e-160.4458040085350061.46952871205154e-310.598897614560159
AC1.6321330766962e-180.51732590904638.49404242375221e-150.4647121872487578.31908350762614e-400.711032042695373
PCC1.31068185234895e-070.3706027318942262.46837433444518e-070.3629427784896321.03451158689006e-140.521479850992582
CER7.11866850378077e-060.3574213558184769.76273099624871e-140.5596031976368311.49327624248476e-060.381161603170081
TCX0.0107638569299650.2076906459356690.0404047923897338-0.1675646725158431.72876026555324e-270.742028358310546
FP1.3141403441377e-050.3202389404324730.9673733978147350.003087538587201913.37385807929451e-190.60563622209251
IFG0.003434544956869020.562338108716230.01642751691592280.4749696292147019.31694100503028e-060.762697196758368
PG0.0223362139309051-0.167459315084150.0212963290500897-0.1687661522541451.15333217482825e-160.558768221356047
STG0.0178472584258210.2579294627752150.981276468516021-0.00259958453054735.99595910180052e-140.706499674241188

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Relation with AD stages for PACS2

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
CERADediting_418045chr14_105370619_+9.87350224198166e-050.365851334879116
CERADediting_418058chr14_105375225_+0.0007071084240305890.320963404272574
TCXADediting_418050chr14_105370821_+7.69567784502671e-060.419278737629795
TCXADediting_418067chr14_105393659_+0.001265247979703490.309078890672671

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER7.35936260758892e-070.455363031374958
TCX9.58401103026805e-050.369753079100033

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RelatedDrugs for PACS2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PACS2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource